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https://www.readbyqxmd.com/read/29227577/management-of-pain-in-end-stage-renal-disease-patients-short-review
#1
REVIEW
Rupesh Raina, Vinod Krishnappa, Mona Gupta
Pain management in end stage renal disease (ESRD) patients is a complex and challenging task to accomplish, and effective pain and symptom control improves quality of life. Pain is prevalent in more than 50% of hemodialysis patients and up to 75% of these patients are treated ineffectively due to its poor recognition by providers. A good history for PQRST factors and intensity assessment using visual analog scale are the initial steps in the management of pain followed by involvement of palliative care, patient and family counseling, discussion of treatment options, and correction of reversible causes...
December 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29225793/recent-advances-in-acute-pain-management-understanding-the-mechanisms-of-acute-pain-the-prescription-of-opioids-and-the-role-of-multimodal-pain-therapy
#2
REVIEW
Richa Wardhan, Jacques Chelly
In this review, we discuss advances in acute pain management, including the recent report of the joint American Pain Society and American Academy of Pain Medicine task force on the classification of acute pain, the role of psychosocial factors, multimodal pain management, new non-opioid therapy, and the effect of the "opioid epidemic". In this regard, we propose that a fundamental principle in acute pain management is identifying patients who are most at risk and providing an "opioid free anesthesia and postoperative analgesia"...
2017: F1000Research
https://www.readbyqxmd.com/read/29211141/hospitalizations-due-to-drug-poisoning-in-under-five-year-old-children-in-brazil-2003-2012
#3
Marta da Cunha Lobo Souto Maior, Claudia Garcia Serpa Osorio-de-Castro, Carla Lourenço Tavares de Andrade
OBJECTIVE: to describe hospitalizations due to drug poisonings in children under five years old, in Brazil, from 2003 to 2012. METHODS: descriptive study, with data from the National Hospital Information System (SIH/SUS); the drugs involved were divided into therapeutic classes, according to the Anatomical Therapeutic Chemical Classification (ATC). RESULTS: 17,725 hospitalizations were identified, from which 22,395 poisonings were identified, and 75 deaths; the most common therapeutic classes were unspecified drugs (38...
October 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29210970/evaluating-the-implementation-of-a-preemptive-multimodal-analgesia-protocol-in-a-plastic-surgery-office
#4
Brandi Tinsbloom, Virginia C Muckler, William T Stoeckel, Robert L Whitehurst, Brett Morgan
Many patients undergoing plastic surgery experience significant pain postoperatively. The use of preemptive, multimodal analgesia techniques to reduce postoperative pain has been widely described in the literature. This quality improvement project evaluated the implementation of a preemptive, multimodal analgesia protocol in an office-based plastic surgery facility to decrease postoperative pain, decrease postoperative opioid consumption, decrease postanesthesia care time, and increase patient satisfaction...
October 2017: Plastic Surgical Nursing
https://www.readbyqxmd.com/read/29208039/effects-of-metamizole-maa-and-paracetamol-on-proliferation-apoptosis-and-necrosis-in-the-pancreatic-cancer-cell-lines-patu-8988%C3%A2-t-and-panc-1
#5
Manuela Malsy, Bernhard Graf, Anika Bundscherer
BACKGROUND: Adenocarcinoma of the pancreas is one of the most aggressive cancer diseases affecting the human body. Recent research has shown the importance of the perioperative phase in disease progression. Particularly during this vulnerable phase, substances such as metamizole and paracetamol are given as general anesthetics and postoperative analgesics. Therefore, the effects of metamizole and paracetamol on tumor progression should be investigated in more detail because the extent to which these substances influence the carcinogenesis of pancreatic carcinoma is still unclear...
December 6, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29207772/comparison-of-pain-relief-from-different-intravenous-doses-of-ketorolac-after-reduction-of-mandibular-fractures
#6
Saeed Nezafati, Reza Khorshidi Khiavi, Seyyed Sina Mirinejhad, Dawood Aghamoh Ammadi, Milad Ghanizadeh
Introduction: Pain is an unpleasant feeling due to tissue destruction, which disturbs an individual's daily routines even at its lowest levels. The majority of surgeons and anaesthesiologists are increasingly trying to administer non-opioid analgesics because excessive use of opioids after surgery results in patient dissatisfaction. Aim: To evaluate the analgesic effect of intravenous injection of different doses of ketorolac at different intervals in patients undergoing surgery for unilateral fractures of the mandible...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29203229/effects-on-hedonic-feeding-energy-expenditure-and-balance-of-the-non-opioid-peptide-dyn-a2-17
#7
B Alvarez, T Barrientos, L Gac, J A Teske, C E Perez-Leighton
The dynorphin (DYN) peptide family includes opioid and non-opioid peptides, yet the physiological role of the non-opioid DYN peptides remains poorly understood. Recent evidence shows that administering the non-opioid peptide DYN-A2-17 into the paraventricular hypothalamic nucleus (PVN) simultaneously increased short-term intake of standard rodent chow and spontaneous physical activity (SPA). The present studies aimed to expand upon the mechanisms and role of DYN-A2-17 on food intake and energy expenditure. Injection of DYN-A2-17 in PVN increased SPA, energy expenditure and wheel running in the absence of food...
December 1, 2017: Neuroscience
https://www.readbyqxmd.com/read/29189516/the-relationship-between-concomitant-benzodiazepine-opioid-use-and-adverse-outcomes-among-u-s-veterans
#8
Laura E Gressler, Bradley C Martin, Teresa J Hudson, Jacob T Painter
Benzodiazepines and opioids are commonly used among Veterans suffering from mental health disorders and pain conditions. The objective of this study is to determine if concomitant benzodiazepine-opioid use increases the incidence of adverse outcomes above the baseline risk of non-acute opioid only use. The dataset contained all Veterans who filled at least one opioid prescription during the years 2008 to 2012. Non-acute opioid use was defined as having opioid prescriptions greater than or equal to 20 days within a 60-day period...
November 20, 2017: Pain
https://www.readbyqxmd.com/read/29172736/role-of-glial-cells-in-%C3%AE-opioid-receptor-mediated-vasodilation-in-the-rat-retina
#9
Eriko Someya, Asami Mori, Daiki Asano, Akane Morita, Kenji Sakamoto, Tsutomu Nakahara
PURPOSE: Our recent study demonstrated that herkinorin, a non-opioid μ-receptor agonist derived from salvinorin A, dilates retinal arterioles through stimulation of μ-opioid receptors in rats. Activation of neuronal nitric oxide (NO) synthase and the presence of ganglion cells in the retina appear to be crucial for inducing μ-opioid receptor-mediated retinal vasodilation. In the present study, we examined the role of the interaction between neurons and glia in the retinal vasodilator mechanism involving μ-opioid receptors in rats...
November 27, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29157034/effects-of-single-dose-preemptive-pregabalin-and-intravenous-ibuprofen-on-postoperative-opioid-consumption-and-acute-pain-after-laparoscopic-cholecystectomy
#10
Omer Karaca, Huseyin U Pınar, Emin Turk, Rafi Dogan, Ali Ahiskalioglu, Sezen K Solak
PURPOSE: Non-opioid medications as a part of multimodal analgesia has been increasingly suggested in the management of acute post-surgical pain. The present study was planned to compare the efficacy of the combination of pregabalin plus ıv ibuprofen. METHODS: 58 patients were included in this prospective, randomized, double-blinded study. The pregabalin group (Group P, n = 29) received 150 mg pregabalin, the pregabalin plus ibuprofen group (Gropu PI, n = 29) received 150 mg pregabalin and 400mg ıv ibuprofen before surgery...
November 20, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29155208/inflammatory-renin-angiotensin-system-disruption-attenuates-sensory-hyperinnervation-and-mechanical-hypersensitivity-in-a-rat-model-of-provoked-vestibulodynia
#11
Anuradha Chakrabarty, Zhaohui Liao, Ying Mu, Peter G Smith
Vestibulodynia is characterized by peri-vaginal mechanical hypersensitivity, hyperinnervation, and abundant inflammatory cells expressing renin-angiotensin system proteins. We developed a tractable rat model of vestibulodynia to further assess the contributions of the renin-angiotensin system. Complete Freund's adjuvant (CFA) injected into the posterior vestibule induced marked vestibular hypersensitivity throughout a 7-day test period. Numbers of axons immunoreactive for PGP9.5, calcitonin gene-related peptide, and GFRα2 were increased...
November 15, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29152935/heterogenic-control-groups-in-randomized-controlled-analgesic-trials-of-total-hip-and-knee-arthroplasty
#12
Anders P Karlsen, Ole Mathiesen, Jørgen B Dahl
BACKGROUND: Postoperative analgesic interventions are often tested adjunct to basic non- opioid analgesics in randomized controlled trials (RCTs). Consequently, treatment in control groups, and assay sensitivity, differs between trials. We hypothesized that postoperative opioid requirements and pain intensities varies between different control groups in analgesic trials. METHODS: Control groups from RCTs investigating analgesic interventions after total hip and knee arthroplasty were categorized based on standardized basic analgesic treatment...
November 17, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29149151/sacroplasty-a-ten-year-analysis-of-prospective-patients-treated-with-percutaneous-sacroplasty-literature-review-and-technical-considerations
#13
Michael E Frey, Christopher Warner, Samuel M Thomas, Karan Johar, Heathpaul Singh, Maheen S Mohammad, Douglas P Beall
BACKGROUND: The treatment of sacral fractures has evolved since its first description in 1982. Several techniques for sacral augmentation have been developed since 2001, and the rate of improvement is rapid with over 50% reduction in pain achieved prior to post-procedure discharge of the patient. Pain reduction occurs primarily within the first 3 months and is sustained at 12 months; however, the long-term outcomes have not previously been studied. OBJECTIVES: We aim to evaluate the long-term efficacy of sacroplasty versus non-surgical management (NSM) in treating sacral insufficiency fractures (SIFs), including the effect on pain relief, opioid and other analgesic use, patient satisfaction, and complication rates...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29139482/opioid-misuse-in-gastroenterology-and-non-opioid-management-of-abdominal-pain
#14
REVIEW
Eva Szigethy, Mitchell Knisely, Douglas Drossman
Opioids were one of the earliest classes of medications used for pain across a variety of conditions, but morbidity and mortality have been increasingly associated with their chronic use. Despite these negative consequences, chronic opioid use is increasing worldwide, with the USA and Canada having the highest rates. Chronic opioid use for noncancer pain can have particularly negative effects in the gastrointestinal and central nervous systems, including opioid-induced constipation, narcotic bowel syndrome, worsening psychopathology and addiction...
November 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29135698/associations-between-early-care-decisions-and-the-risk-for-long-term-opioid-use-for-patients-with-low-back-pain-with-a-new-physician-consultation-and-initiation-of-opioid-therapy
#15
Julie M Fritz, Jordan B King, Carrie McAdams-Marx
OBJECTIVE: Identify associations between early care decisions and long-term opioid use in opioid-naïve patients with a new physician consultation for low back pain at which an opioid was prescribed. METHODS: Retrospective study of claims data was used to identify opioid-naïve low back pain patients who were prescribed opioids at the index physician visit. Early care variables captured included additional non-opioid medications prescribed within 14 days, and provider visits or diagnostic imaging within 30 days of the index visit...
November 10, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29130384/characterising-the-growth-in-palliative-care-prescribing-2011-2015-analysis-of-national-medical-and-non-medical-activity
#16
Lucy Ziegler, Michael I Bennett, Matt Mulvey, Tim Hamilton, Alison Blenkinsopp
BACKGROUND: The role of non-medical prescribers working in palliative care has been expanding in recent years and prescribers report improvements in patient care, patient safety, better use of health professionals' skills and more flexible team working. Despite this, there is a lack of empirical evidence to demonstrate its clinical and economic impact, limiting our understanding of the future role of non-medical prescribers within a healthcare system serving an increasing number of people with palliative care needs...
November 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29127600/a-review-of-current-and-emerging-approaches-to-pain-management-in-the-emergency-department
#17
REVIEW
Knox H Todd
INTRODUCTION: Pain is the most common symptom prompting an emergency department visit and emergency physicians are responsible for managing both acute pain and acute exacerbations of chronic pain resulting from a broad range of illnesses and injuries. The responsibility to treat must be balanced by the duty to limit harm resulting from analgesics. In recent years, opioid-related adverse effects, including overdose and deaths, have increased dramatically in the USA. In response to the US opioid crisis, emergency physicians have broadened their analgesic armamentarium to include a variety of non-opioid approaches...
December 2017: Pain and Therapy
https://www.readbyqxmd.com/read/29119401/role-of-endogenous-agonists-of-opioid-receptors-in-the-regulation-of-heart-resistance-to-postischemic-reperfusion-injury
#18
A S Gorbunov, O E Vaizova, M V Belousov, S V Pozdnyakova, E A Nesterov, P G Madonov
Intravenous injection of nonselective antagonists of opioid receptors (OR) naltrexone (5 mg/kg) and naloxone methiodide (5 mg/kg), selective δ1-OR antagonist BNTX (0.7 mg/kg), selective δ2-OR blocker naltriben (0.3 mg/kg), selective κ-OR antagonist norbinaltorphimine (2 mg/kg), and selective blocker of ORL1 opioid receptors JTC-801 (0.1 mg/kg) produced no effect on reperfusion injury to the heart in rats narcotized with α-chloralose. In contrast, selective μ-OR antagonist CTAP (1 mg/kg) limited the infarct size, although this effect was not observed at a lower CTAP concentration of 0...
November 9, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29113970/no-difference-in-efficacy-of-opioids-and-non-opioid-analgesics-for-arm-or-leg-pain
#19
Jacqui Wise
No abstract text is available yet for this article.
November 7, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29084357/adverse-events-associated-with-medium-and-long-term-use-of-opioids-for-chronic-non-cancer-pain-an-overview-of-cochrane-reviews
#20
REVIEW
Charl Els, Tanya D Jackson, Diane Kunyk, Vernon G Lappi, Barend Sonnenberg, Reidar Hagtvedt, Sangita Sharma, Fariba Kolahdooz, Sebastian Straube
BACKGROUND: Chronic pain is common and can be challenging to manage. Despite increased utilisation of opioids, the safety and efficacy of long-term use of these compounds for chronic non-cancer pain (CNCP) remains controversial. This overview of Cochrane Reviews complements the overview entitled 'High-dose opioids for chronic non-cancer pain: an overview of Cochrane Reviews'. OBJECTIVES: To provide an overview of the occurrence and nature of adverse events associated with any opioid agent (any dose, frequency, or route of administration) used on a medium- or long-term basis for the treatment of CNCP in adults...
October 30, 2017: Cochrane Database of Systematic Reviews
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