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https://www.readbyqxmd.com/read/29673974/randomized-controlled-trial-of-nurse-delivered-cognitive-behavioral-therapy-versus-supportive-psychotherapy-telehealth-interventions-for-chronic-back-pain
#1
Thomas Rutledge, J Hampton Atkinson, Rachael Holloway, Tatiana Chircop-Rollick, John D'Andrea, Steven R Garfin, Shetal Patel, Donald B Penzien, Mark Wallace, Anne L Weickgenant, Mark Slater
This study evaluated a nurse-delivered, telehealth intervention of cognitive behavioral therapy versus supportive psychotherapy for chronic back pain. Participants (N=61) had chronic back pain (pain "daily" ≥ 6 months at an intensity ≥4/10 scale) and were randomized to an 8-week, 12-session, Cognitive Behavioral Therapy (CBT) or to Supportive Care (SC) matched for frequency, format, and time, with each treatment delivered by a primary care nurse. The primary outcome was the Roland Morris Disability Questionnaire (RMDQ)...
April 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29673620/effects-of-opioid-and-non-opioid-analgesics-on-responses-to-psychosocial-stress-in-humans
#2
Anya K Bershad, Melissa A Miller, Greg J Norman, Harriet de Wit
Both preclinical and clinical evidence suggests that the endogenous opioid system is involved in responses to stress. For example, in animal models opioid agonists reduce isolation distress whereas opioid antagonists increase isolation distress. We recently reported that the mixed mu agonist and kappa antagonist buprenorphine dampened responses to acute psychosocial stress in humans. Now we extend this to study the effects of a pure mu-opioid agonist, hydromorphone, and a non-opioid analgesic, acetaminophen, on response to social stress...
April 16, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29663315/pro-region-engineering-of-nerve-growth-factor-by-deep-mutational-scanning-enables-a-yeast-platform-for-conformational-epitope-mapping-of-anti-ngf-monoclonal-antibodies
#3
Angélica V Medina-Cucurella, Yaqi Zhu, Scott J Bowen, Lisa M Bergeron, Timothy A Whitehead
Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti-NGF monoclonal antibodies (mAbs) that function by antagonizing NGF downstream signaling are leading drug candidates for non-opioid pain relief. To evaluate anti-canine NGF (cNGF) mAbs we sought a yeast surface display platform of cNGF. Both mature cNGF and pro-cNGF displayed on the yeast surface but bound conformationally sensitive mAbs at most 2.5-fold in mean fluorescence intensity above background, suggesting that cNGF was mostly misfolded...
April 16, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29660744/-need-of-analgetics-in-children-aged-2-12-years-after-tonsil-surgery
#4
Philipp Gude, Claudia Rieckert, Nicolai Bissantz, Thomas Peter Weber, Heike Vogelsang, Stefan Dazert, Jan Peter Thomas
OBJECTIVE: Tonsil surgery is one of the most painful operations in childhood. The Children's and Infants' Postoperative Pain Scale (CHIPPS), the Faces Pain Scale-Revised (FPS-R) and the little-known German version of the parents' postoperative pain measure (PPPM-D) are age-appropriate measures. Children undergoing intracapsular tonsillectomy (TO) or extracapsular tonsillectomy (TE) received the non-opioids ibuprofen (IBU) and paracetamol (PCM) on a "as needed"-basis requested by parents...
April 16, 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29653244/opioid-utilization-following-cervical-spine-surgery-trends-and-factors-associated-with-long-term-use
#5
Andrew J Pugely, Nicholas A Bedard, Piyush Kalakoti, Nathan R Hendrickson, Jamal N Shillingford, Joseph L Laratta, Comron Saifi, Ronald A Lehman, K Daniel Riew
BACKGROUND CONTEXT: Limited or no data exist evaluating risk-factors associated with prolonged opioid use following cervical arthrodesis. PURPOSE: To assess trends in post-operative narcotic use amongst preoperative opioid users (OU) versus non-opioid users (NOU), and identify factors associated with postoperative narcotic use at 1-year following cervical arthrodesis. STUDY DESIGN/SETTING: Retrospective, observational study. PATIENT SAMPLE: 17,391 patients (OU: 52...
April 10, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29649914/positive-affect-skills-may-improve-pain-management-in-people-with-hiv
#6
Elizabeth L Addington, Elaine O Cheung, Judith T Moskowitz
Non-opioid pain management strategies are critically needed for people with HIV. We therefore conducted a secondary analysis of pain-related outcomes in a randomized controlled trial of a positive affect skills intervention for adults newly diagnosed with HIV ( N = 159). Results suggest that, even if pain prevalence rises, positive affect skills may reduce pain interference and prevent increased use of opioid analgesics by people living with HIV. Future research should replicate and extend these findings by conducting trials that are specifically designed to target pain outcomes...
April 1, 2018: Journal of Health Psychology
https://www.readbyqxmd.com/read/29644656/pro-region-engineering-of-nerve-growth-factor-by-deep-mutational-scanning-enables-a-yeast-platform-for-conformational-epitope-mapping-of-anti-ngf-monoclonal-antibodies
#7
Angélica V Medina-Cucurella, Yaqi Zhu, Scott J Bowen, Lisa M Bergeron, Timothy A Whitehead
Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti-NGF monoclonal antibodies (mAbs) that function by antagonizing NGF downstream signaling are leading drug candidates for non-opioid pain relief. To evaluate anti-canine NGF (cNGF) mAbs we sought a yeast surface display platform of cNGF. Both mature cNGF and pro-cNGF displayed on the yeast surface but bound conformationally sensitive mAbs at most 2.5-fold in mean fluorescence intensity above background, suggesting that cNGF was mostly misfolded...
April 12, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29626143/opioid-analgesia-on-the-battlefield-a-retrospective-review-of-data-from-operation-herrick
#8
Pip Lewis, C Wright, C Hooper
BACKGROUND: Acute pain secondary to trauma is commonly encountered on the battlefield. The use of morphine to manage pain during combat has been well established since the 19th century. Despite this, there is relatively little research on analgesia use in this environment. This study aims to review the use and complications of morphine and other opioids during Operation HERRICK. METHODS: A database search of the Joint Theatre Trauma Registry was completed looking for all incidences of morphine, fentanyl or naloxone use from February 2007 to September 2014...
April 6, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29619627/new-advances-in-acute-postoperative-pain-management
#9
REVIEW
Sukanya Mitra, Daniel Carlyle, Gopal Kodumudi, Vijay Kodumudi, Nalini Vadivelu
PURPOSE OF REVIEW: Postoperative pain remains one of the most common challenges following inpatient and outpatient surgeries. With our advances in modern medicine, pain following surgical procedures still remains a challenge, though significant accomplishments have been made over the past few decades. This article highlights some of the promising new advances and approaches in postoperative pain management. RECENT FINDINGS: Over the last decade, Enhanced Recovery after Surgery (ERAS) pathways and protocols are becoming the benchmark standards for enhancing postoperative recovery...
April 4, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29597083/traumatic-brain-injury-and-receipt-of-prescription-opioid-therapy-for-chronic-pain-in-iraq-and-afghanistan-veterans-do-clinical-practice-guidelines-matter
#10
Karen H Seal, Daniel Bertenthal, Deborah E Barnes, Amy L Byers, Carolyn J Gibson, Kristine Yaffe
Clinical practice guidelines admonish against prescribing opioids for individuals with chronic pain and traumatic brain injury (TBI) given increased risk for adverse outcomes, yet no studies have described opioid prescribing patterns in these higher risk patients. Between October 2007 and March 2015, 53,124 Iraq and Afghanistan veterans with chronic pain not prescribed opioids in the previous year were followed for one year after completing a Comprehensive TBI Evaluation (CTBIE) within Department of Veterans Affairs health care facilities...
March 26, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29579724/associations-between-opioid-and-nicotine-dependence-in-nationally-representative-samples-of-united-states-adult-daily-smokers
#11
Maria A Parker, Joanna M Streck, Stacey C Sigmon
INTRODUCTION: Smoking prevalence among adults with opioid dependence far exceeds that of the general population, and cessation outcomes in this group are one-fourth that of smokers without a substance use disorder. Understanding the reasons underlying these poor outcomes is critical for developing more effective smoking interventions in this group. Elevated baseline severity of nicotine dependence is associated with lower rates of smoking cessation over time. We examined whether nicotine dependence severity among smokers may vary as a function of opioid dependence status using nationally representative samples of adult smokers...
March 15, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29569172/a-retrospective-evaluation-of-the-perioperative-drug-use-and-comparison-of-its-cost-in-robotic-vs-open-surgery-for-endometrial-cancer
#12
Reshu Agarwal, Anupama Rajanbabu, U G Unnikrishnan
To compare the usage and cost of analgesics (opioid and non-opioids), antiemetics, and IV fluids and its associated costs in robotic vs open staging surgery for endometrial cancer (EC). This retrospective study was performed at a single academic institution from January 2014 to June 2017 in the department of Gynecology Oncology at Amrita Institute of Medical Science, Kerala, India. The study included women with biopsy confirmed clinically early stage endometrial cancer or atypical hyperplasia, who underwent robotic-assisted or open staging surgery...
March 22, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29555608/non-opioids-prove-non-inferior-for-chronic-pain-results-of-the-space-trial
#13
John Paul G Kolcun, G Damian Brusko, Michael Y Wang
No abstract text is available yet for this article.
March 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29542370/role-of-primary-care-physicians-in-intrathecal-pain-management-a-narrative-review-of-the-literature
#14
Gladstone C McDowell, Joseph Winchell
OBJECTIVES: The majority of patients seeking medical care for chronic pain consult a primary care physician (PCP). Because systemic opioids are commonly prescribed to patients with chronic pain, PCPs are attempting to balance the competing priorities of providing adequate pain relief while reducing risks for opioid misuse and overdose. It is important for PCPs to be aware of pain management strategies other than systemic opioid dose escalation when patients with chronic pain fail to respond to conservative therapies and to initiate a multimodal treatment plan...
March 28, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29537399/gabapentin-and-pregabalin-do-the-benefits-outweigh-the-harms
#15
E E Morrison, E A Sandilands, D J Webb
Gabapentin and pregabalin prescribing in Scotland has increased substantially over recent years. Evidence suggests that prescribers may be advocating the use of these medicines off-label to avoid prescribing opioid analgesics. The evidence to support gabapentin and pregabalin use in non-neuropathic pain disorders indicates they are less effective than several other licensed non-opioid analgesics. Notably, patients may not benefit from gabapentin and pregabalin but remain at risk of adverse drug reactions. Furthermore, greater availability has resulted in increased diversion of gabapentin and pregabalin; creating problems within the opioid misuse population and prison service...
December 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29524352/the-role-and-mechanism-of-action-of-menthol-in-topical-analgesic-products
#16
REVIEW
J V Pergolizzi, R Taylor, J-A LeQuang, R B Raffa
WHAT IS KNOWN AND OBJECTIVE: Menthol has been used as a non-opioid pain reliever since ancient times. A modern understanding of its molecular mechanism of action could form the basis for generating targets for discovery of novel non-opioid analgesic drugs. METHODS: The PubMed database was queried using search words related to menthol, pain and analgesia. The results were limited to relevant preclinical studies and clinical trials and reviews published in English during the past 5 years, which yielded 31 reports...
March 10, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29520812/nature-s-first-atypical-opioids-kratom-and-mitragynines
#17
R B Raffa, J V Pergolizzi, R Taylor, M H Ossipov
WHAT IS KNOWN AND OBJECTIVE: Advances in pain research have led to an understanding that many pains are driven by more than one underlying (patho)physiologic cause (ie, they are "multimechanistic") and that better pain relief is obtained with fewer adverse effects when an analgesic is correspondingly multimechanistic. At least two of the more-modern analgesics combine opioid and non-opioid mechanisms, and have become known as "atypical opioids." Less well known is that just as Nature evolved opioids, it also evolved atypical opioids, presaging modern drug discovery efforts...
March 8, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29514410/trends-in-analgesic-consumption-in-france-over-the-last-10-years-and-comparison-of-patterns-across-europe
#18
Karima Hider-Mlynarz, Philippe Cavalié, Patrick Maison
AIMS: To describe consumption trends of three groups of analgesics (non-opioids, mild and strong opioids) between 2006 and 2015 in France, and compare this pattern of use with six European countries in 2015. METHODS: Annual drugs sales were extracted from the French national authority's consumption database and from the IMS-MIDAS and national databases for European countries. RESULTS: The use of mild opioids in France decreased by 53% during the last 10 years due to the declining use of dextropropoxyphene combinations, along with an increase in the use of non-opioids and strong opioids (from 72 to 93 and 2 to 2...
March 7, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29499361/post-discharge-opioid-prescribing-and-use-after-common-surgical-procedures
#19
Mayo H Fujii, Ashley C Hodges, Ruby L Russell, Kristin Roensch, Bruce Beynnon, Thomas P Ahern, Peter Holoch, Jesse S Moore, S Elizabeth Ames, Charles D MacLean
BACKGROUND: The number of deaths from prescription opioids in the United States continues to increase and remains a major public health concern. Opioid-related deaths parallel prescribing trends and post-operative opioids are a significant source of opioids in the community. Our objective was to identify opioid prescribing and use patterns after surgery to inform evidenced-based practices. STUDY DESIGN: Data from a 340-bed academic medical institution and its affiliated outpatient surgical facility included: 1) retrospective medical record data, 2) prospective telephone questionnaire and medical record data...
February 27, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29494417/monthly-vitamin-d-supplementation-pain-and-pattern-of-analgesic-prescription-secondary-analysis-from-the-randomized-double-blind-placebo-controlled-vida-study
#20
Zhenqiang Wu, Carlos A Camargo, Zarintaj Malihi, Jim Bartley, Debbie Waayer, Carlene M M Lawes, Les Toop, Kay-Tee Khaw, Robert Scragg
Observational studies suggest that vitamin D deficiency is associated with higher risk of pain. However, evidence on the effect of vitamin D supplementation on pain is limited and contradictory. The aim of this study was to compare the effect of monthly high-dose vitamin D supplementation on a pain impact questionnaire (PIQ-6) score and prescription of analgesics in the general population. We performed a randomized, double-blind, placebo-controlled trial of 5108 community-dwelling participants, aged 50-84 years, who were randomly assigned to receive monthly 100,000-IU capsules of vitamin D3 (n=2558) or placebo (n=2550) for a median of 3...
February 24, 2018: Pain
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