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Superoxide anion AND Quercetin

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https://www.readbyqxmd.com/read/27796749/quercetin-exerts-differential-neuroprotective-effects-against-h2o2-and-a%C3%AE-aggregates-in-hippocampal-neurons-the-role-of-mitochondria
#1
Juan A Godoy, Carolina B Lindsay, Rodrigo A Quintanilla, Francisco J Carvajal, Waldo Cerpa, Nibaldo C Inestrosa
Amyloid-β peptide (Aβ) is one of the major players in the pathogenesis of Alzheimer's disease (AD). Despite numerous studies, the mechanisms by which Aβ induces neurodegeneration are not completely understood. Oxidative stress is considered a major contributor to the pathogenesis of AD, and accumulating evidence indicates that high levels of reactive oxygen species (ROS) are involved in Aβ-induced neurodegeneration. Moreover, Aβ can induce the deregulation of calcium homeostasis, which also affects mitochondrial function and triggers neuronal cell death...
October 28, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27695265/in-vitro-antioxidant-activities-and-polyphenol-contents-of-seven-commercially-available-fruits
#2
Paramita Basu, Camelia Maier
BACKGROUND: Fruits are considered one of the richest sources of natural antioxidants. Their consumption has been linked to the prevention of oxidative stress-induced diseases. OBJECTIVE: In this study, in vitro antioxidant activities of blueberry, jackfruit, blackberry, black raspberry, red raspberry, strawberry, and California table grape extracts were evaluated. MATERIALS AND METHODS: Antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant potential (FRAP), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), nitric oxide (NO), superoxide anion (O2(-)) scavenging assays, and ferric reducing power...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27688827/antioxidant-and-vasodilator-activity-of-ugni-molinae-turcz-murtilla-and-its-modulatory-mechanism-in-hypotensive-response
#3
Ignacio Jofré, Cesar Pezoa, Magdalena Cuevas, Erick Scheuermann, Irlan Almeida Freires, Pedro Luiz Rosalen, Severino Matias de Alencar, Fernando Romero
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response. Murtilla fruits were cultivated in a germplasm bank and submitted to chemical and biological analyses. The phenolic compounds gallic acid, Catechin, Quercetin-3-β-D-glucoside, Myricetin, Quercetin, and Kaempferol were identified...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27589790/molecular-targets-underlying-the-anticancer-effects-of-quercetin-an-update
#4
REVIEW
Fazlullah Khan, Kamal Niaz, Faheem Maqbool, Fatima Ismail Hassan, Mohammad Abdollahi, Kalyan C Nagulapalli Venkata, Seyed Mohammad Nabavi, Anupam Bishayee
Quercetin, a medicinally important member of the flavonoid family, is one of the most prominent dietary antioxidants. It is present in a variety of foods-including fruits, vegetables, tea, wine, as well as other dietary supplements-and is responsible for various health benefits. Numerous pharmacological effects of quercetin include protection against diseases, such as osteoporosis, certain forms of malignant tumors, and pulmonary and cardiovascular disorders. Quercetin has the special ability of scavenging highly reactive species, such as hydrogen peroxide, superoxide anion, and hydroxyl radicals...
2016: Nutrients
https://www.readbyqxmd.com/read/27517880/evaluation-of-antioxidant-anti-cholinesterase-and-antidiabetic-potential-of-dry-leaves-and-stems-in-tamarix-aphylla-growing-wild-in-tunisia
#5
Adel Mahfoudhi, Clara Grosso, Rui F Gonçalves, Eltaief Khelifi, Saoussen Hammami, Sami Achour, Malika Trabelsi Ayadi, Patrícia Valentão, Paula B Andrade, Zine Mighri
Tamarix aphylla (L.) Karst. has a wide geographic distribution and was employed in traditional medicine as astringent, anti-rheumatic and to treat fever. T. aphylla leaves and stems extracts were studied from both chemical and biological points of view to assess the antidiabetic, anti-cholinesterase and antioxidant potential of this species. The HPLC/DAD analysis showed the presence of 14 phenolic compounds (gallic, caffeic, p-coumaric, ferulic and ellagic acids, kaempferol, quercetin, quercetin-3-O-galactoside and six flavonol derivatives)...
August 12, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27500876/-an-experimental-in-vitro-study-of-antioxidant-and-antiradical-properties-of-cytoflavin-vinpocetine-actovegin-and-ethylmethylhydroxypyridine-succinate
#6
S A Trofimova, E E Dubinina, O A Balunov, N V Leonova
AIM: To investigate experimentally in vitro the antioxidant and anti-radical activity of several drugs. MATERIAL AND METHODS: Antioxidant activity was assessed by induced luminol-dependent chemiluminescence (CL). An impact on the generation of reactive oxygen species (O2-, OH, 1D, H2O2, HClO) and their ability to inhibit the auto-oxidation of quercetin combined with the generation of superoxide radical anion were determined. Anti-radical activity was studied by the method of restoring a stable radical α-α-diphenyl-β-picryl hydrazine (DPPH) molecule of the alleged anti-oxidant...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27365982/evaluation-of-skin-anti-aging-potential-of-citrus-reticulata-blanco-peel
#7
Vinita D Apraj, Nancy S Pandita
BACKGROUND: The peel of Citrus reticulata Blanco is traditionally used as tonic, stomachic, astringent, and carminative. It is also useful in skin care. OBJECTIVE: To study the anti-aging potential of alcoholic extracts of C. reticulata Blanco peel using in vitro antioxidant and anti-enzyme assays. MATERIALS AND METHODS: Plant extracts were obtained by Soxhlation (CR HAE- Hot Alcoholic Extract of Citrus reticulata) and maceration method (CR CAE- Cold Alcoholic Extract of Citrus reticulata)...
July 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27279535/antioxidant-potential-of-the-giant-mushroom-macrocybe-gigantea-agaricomycetes-from-india-in-different-drying-methods
#8
Tanvi Gaur, P B Rao
Free radicals are responsible for several diseases like cancer, atherosclerosis, gastric ulcers, and several others. Studies have shown that mushrooms possess antioxidant activity and Macrocybe gigantea was recently added to the list of mushrooms under cultivation in India. The methanolic extracts were prepared from lyophilized and oven-dried samples of MA1 and MA2 strains of M. gigantea and their antioxidant properties were studied. MA2 showed comparatively higher total antioxidant activity (111.88 µg/mg) than MA1 (97...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27224288/17-dmag-an-hsp90-inhibitor-ameliorates-multiple-organ-dysfunction-syndrome-via-induction-of-hsp70-in-endotoxemic-rats
#9
Yi-Li Wang, Hsin-Hsueh Shen, Pao-Yun Cheng, Yen-Ju Chu, Hwong-Ru Hwang, Kwok-Keung Lam, Yen-Mei Lee
Sepsis is a systemic inflammatory disorder, accompanied with elevated oxidative stress, leading to multiple organ dysfunction syndrome (MODS), and disseminated intravascular coagulation. 17-Dimethylaminoethylamino- 17-demethoxygeldanamycin (17-DMAG), a heat shock protein (HSP) 90 inhibitor, has been reported to possess anti-inflammatory effects. In this study, the beneficial effects of 17-DMAG on lipopolysaccharide (LPS) induced MODS and DIC was evaluated in anesthetized rats. 17-DMAG (5 mg/kg, i.p.) was significantly increased survival rate, and prevented hypotension in LPS (30 mg/kg i...
2016: PloS One
https://www.readbyqxmd.com/read/27213823/polyphenols-from-silybum-marianum-inhibit-in%C3%A2-vitro-the-oxidant-response-of-equine-neutrophils-and-myeloperoxidase-activity
#10
A Zholobenko, A Mouithys-Mickalad, M Modriansky, D Serteyn, T Franck
A recent study showed that silymarin, a standardized extract of S. marianum might be used in the prevention of equine laminitis. We investigated the effects of quercetin and some compounds found in silymarin (silybin, taxifolin and dehydrosilybin) on reactive oxygen species (ROS) production and myeloperoxidase (MPO) release by stimulated equine neutrophils (PMNs) and on MPO activity. All compounds (tested between 100 nm and 100 μm) inhibited superoxide anion production by stimulated PMNs in a dose-dependent manner...
May 23, 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27012965/the-bioflavonoid-quercetin-synergises-with-ppar-%C3%AE-agonist-pioglitazone-in-reducing-angiotensin-ii-contractile-effect-in-fructose-streptozotocin-induced-diabetic-rats
#11
Thubasni Kunasegaran, Mohd Rais Mustafa, Dharmani Devi Murugan, Francis I Achike
This study investigated the effects of combined minimal concentrations of quercetin and pioglitazone on angiotensin II-induced contraction of the aorta from fructose-streptozotocin (F-STZ)-induced type 2 diabetic rats and the possible role of superoxide anions (O2(-)) and nitric oxide (NO) in their potential therapeutic interaction. Contractile responses to Ang II of aortic rings from Sprague-Dawley (SD) and F-STZ rats were tested following pre-incubation of the tissues in the vehicle (DMSO; 0.05%), quercetin (Q, 0...
June 2016: Biochimie
https://www.readbyqxmd.com/read/26749809/lipid-metabolites-from-the-mushroom-meripilus-giganteus
#12
Francesca Catenia, Tiziano Altieri, Marina Zacchigna, Giuseppe Procida, Jelena Zilic, Dusan Zigon, Angelo Cichelli
The phytochemical investigation of the methanolic extract of the white rot fungus Meripilus giganteus resulted in the isolation and identification of complex mixtures of free fatty acids (1), monoacylglycerols (2), cerebrosides (3), ergosterol (4) and ergosterol peroxide (5). The structures of the isolated lipid metabolites (1-5) were determined by chemical and spectroscopic methods. The antioxidant activity of the whole MeOH extract of the fungus was evaluated through in vitro model systems, such as 2,2-diphenyl-l-picrylhydrazyl (DPPH) and superoxide anion...
November 2015: Natural Product Communications
https://www.readbyqxmd.com/read/26681073/on-the-pharmacology-of-oxidative-burst-of-human-neutrophils
#13
R Nosáľ, K Drábiková, V Jančinová, T Mačičková, J Pečivová, T Perečko, J Harmatha, J Šmidrkal
The effect of three therapeutically used drugs and five polyphenolic compounds on the mechanism of oxidative burst was compared in whole blood and isolated neutrophils at cellular and molecular level. In 10 microM concentration, the compounds investigated decreased the oxidative burst of whole blood in the rank order of potency: N-feruloylserotonin (N-f-5HT) > curcumin (CUR) > quercetin (QUER) > arbutin (ARB) > resveratrol (RES) > dithiaden (DIT) > carvedilol (CARV) > brompheniramine (BPA)...
2015: Physiological Research
https://www.readbyqxmd.com/read/26633020/importance-of-proton-coupled-electron-transfer-from-natural-phenolic-compounds-in-superoxide-scavenging
#14
Tatsushi Nakayama, Bunji Uno
The superoxide O2(·-) scavenging reaction of (+)-catechin (Cat), quercetin (Que), rutin, and α-tocopherol (α-TOH) as natural phenolic compounds is investigated on the basis of electrochemical and ESR spectral measurements with the aid of density functional theory (DFT) calculations. Reversibility of the O2/O2(·-) redox couple is significantly affected by the presence of the phenolic compounds. The catechol moiety of Cat, Que, and rutin plays an essential role in concerted proton-coupled electron transfer (PCET) to HO2(·) derived from O2(·-) to give H2O2 and the corresponding o-benzoquinone radical anions...
2015: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/26559697/antioxidant-properties-of-oak-bracket-mushroom-pseudoinonotus-dryadeus-higher-basidiomycetes-a-mycochemical-study
#15
Francesca Cateni, Marina Zacchigna, Tiziano Altieri, Giuseppe Procida, Angelo Cichelli
A complex mixture of free fatty acids (1), cerevisterol (2), a sphingosine (3), and a complex mixture of diacylglycerophospholipids (4) were isolated from the fruiting body of the basidiomycete mushroom Pseudoinonotus dryadeus and subjected to spectroscopic analyses. The antioxidant activities of the whole extract of the fungus, of the isolated fractions, and of compounds 1-4 were evaluated in two in vitro model systems: 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and superoxide anion. In each systems, the extract of fungus and compound 2 showed the same free radical scavenging activity (with SC50 data of 18...
2015: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/26461382/stem-bark-and-flower-extracts-of-vismia-cauliflora-modulation-of-oxidative-burst-in-human-neutrophils-and-inhibition-of-oxidative-damage-in-human-erythrocytes
#16
Alessandra Braga Ribeiro, Alessandra Berto, Daniela Ribeiro, Marisa Freitas, Renan Campos Chisté, Jesuí Vergílio Visentainer, Eduarda Fernandes
Vismia cauliflora is an Amazonian plant traditionally used to treat dermatosis and inflammatory processes of the skin by indigenous population. Our research group showed that stem bark and flower extracts of V. cauliflora are efficient in vitro scavengers of reactive oxygen and nitrogen species. In this study, we determined the activity of stem bark and flower extracts of V. cauliflora plant on the modulation of in vitro oxidative burst in human neutrophils and their potential to inhibit the oxidative damage in human erythrocytes...
October 2014: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/26059142/improving-the-antioxidant-activity-of-buckwheat-fagopyrum-tataricm-gaertn-sprout-with-trace-element-water
#17
Cheng-Kuang Hsu, Been-Huang Chiang, Yih-Shyuan Chen, Joan-Hwa Yang, Chia-Ling Liu
Trace element water (TEW) (100, 200, 300, 400 and 500ppm) was used to grow buckwheat (Fagopyrum tataricm Gaertn) to evaluate whether the beneficial effects of trace elements on the antioxidant activity could be accomplished with the supplement of TEW. At 300ppm, TEW significantly increased the Cu, Zn and Fe contents in buckwheat sprout, but not the Se and Mn contents. The levels of rutin, quercitrin and quercetin did not differ between buckwheat sprouts grown in TEW and de-ionized water (DIW). The ethanolic extract from buckwheat sprout grown in 300ppm TEW showed higher DPPH radical scavenging activity, ferrous ion chelating activity, superoxide anion scavenging activity and inhibitory activity toward lipid peroxidation than that grown in DIW...
May 15, 2008: Food Chemistry
https://www.readbyqxmd.com/read/25976789/bioactivities-of-phytochemicals-in-araiostegia-yunnanensis-christ
#18
Longsheng Chen, Wei Xu, Rong Shao, Xianfeng Du
The profile and bioactivity of phytochemicals in Araiostegia yunnanensis (Christ) Cop were investigated. The total flavonoids content in A. yunnanensis is about 84.90 mg/g. By means of HPLC-DAD-ESI-MS, the main flavonoids in A. yunnanensis were tentatively identified as myricetin 3-O-rhamnosylglucoside, eriodictyol 7-O-rutinoside, quercetin 3-O-rutinoside, luteolin-7-O-apiosylglucoside, quercetin 3-O-rhamnosylgalactoside, and luteolin 7-O-glucoside. The extract (0.268 mg/ml total flavonoids) from A. yunnanensis showed very strong superoxide anion radical scavenging potential and reducing power, which are higher than those of rutin (0...
November 1, 2015: Food Chemistry
https://www.readbyqxmd.com/read/25929518/beneficial-effects-of-quercetin-on-renal-injury-and-oxidative-stress-caused-by-ciprofloxacin-in-rats-a-histological-and-biochemical-study
#19
H Elbe, Z Dogan, E Taslidere, A Cetin, Y Turkoz
Ciprofloxacin is a broad-spectrum quinolone antibiotic commonly used in clinical practice. Quercetin is an antioxidant belongs to flavonoid group. It inhibits the production of superoxide anion. In this study, we aimed to evaluate the effects of quercetin on renal injury and oxidative stress caused by ciprofloxacin. Twenty-eight female Wistar albino rats were divided into four groups: control, quercetin (20 mg kg(-1) day(-1) gavage for 21 days), ciprofloxacin (20 mg kg(-1) twice a day intraperitoneally for 10 days), and ciprofloxacin + quercetin...
March 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/25732585/a-colourimetric-sensor-for-the-simultaneous-determination-of-oxidative-status-and-antioxidant-activity-on-the-same-membrane-n-n-dimethyl-p-phenylene-diamine-dmpd-on-nafion
#20
Sema Demirci Çekiç, Asli Neslihan Avan, Seda Uzunboy, Reşat Apak
A colourimetric sensor capable of simultaneously measuring oxidative status (OS) in terms of the hazard produced by reactive oxygen species (ROS) and antioxidant activity (AOA) in regard to ROS-scavenging ability of antioxidant compounds was developed. The coloured cationic semi-quinone derivatives, caused by ROS oxidative degradation of N,N-dimethyl-p-phenylene diamine hydrochloride (DMPD) in pH 5.7 acetate-buffered medium, were formed in solution and immobilized on a perfluorosulfonate-based Nafion membrane...
March 20, 2015: Analytica Chimica Acta
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