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Superoxide AND Quercetin

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https://www.readbyqxmd.com/read/28317313/profiling-of-antioxidative-enzyme-expression-induced-by-various-food-components-using-targeted-proteome-analysis
#1
Sven Bartenbacher, Christiane Östreicher, Monika Pischetsrieder
SCOPE: A method was developed for targeted proteome analysis of the expression profile of a set of antioxidative enzymes in rat macrophages and applied to screen the antioxidative potential of several food components/foods. METHODS AND RESULTS: Expression profiles of heme oxygenase 1, peroxiredoxin 1, thioredoxin reductase 1, glutathione reductase, glutathione-S transferase P1, and superoxide dismutase 1 were analyzed by nanoLC-MS/MS in selected scheduled reaction monitoring (sSRM) mode monitoring 2-3 peptides per protein and 3 transitions per peptide...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28315349/diethylstilbestrol-induces-oxidative-dna-damage-resulting-in-apoptosis-of-spermatogonial-stem-cells-in-vitro
#2
Khaled Habas, Martin H Brinkworth, Diana Anderson
The spermatogonial stem cells (SSCs) are the only germline stem cells in adults that are responsible for the transmission of genetic information from mammals to the next generation. SSCs play a very important role in the maintenance of progression of spermatogenesis and help provide an understanding of the reproductive biology of future gametes and a strategy for diagnosis and treatment of infertility and male reproductive toxicity. Androgens/oestrogens are very important for the suitable maintenance of male germ cells...
March 14, 2017: Toxicology
https://www.readbyqxmd.com/read/28296180/antioxidant-capacity-phenolic-constituents-and-toxicity-of-hot-water-extract-from-red-maple-buds
#3
Naamwin R Meda, Patrice E Poubelle, Tatjana Stevanovic
The present study reports, for the first time, the results of the antioxidant capacity and the phenolic composition of a hot water extract from red maple buds (RMB), as well as its safety. In this regard and comparatively to antioxidant standards, this extract exhibits a significant antiradical capacity when tested by 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and anion superoxide trapping assays. High-resolution mass spectrometric (HRMS) and Nuclear Magnetic Resonance (NMR) analyses permitted to determine for the first time, in red maple species, cyanidin-3-O-glucoside, quercetin-3-O-galactoside, quercetin-3-O-arabinoside and quercetin...
March 11, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28272303/effects-of-silver-nanoparticles-on-multiple-drug-resistant-strains-of-staphylococcus-aureus-and-pseudomonas-aeruginosa-from-mastitis-infected-goats-an-alternative-approach-for-antimicrobial-therapy
#4
Yu-Guo Yuan, Qiu-Ling Peng, Sangiliyandi Gurunathan
Recently, silver nanoparticles (AgNPs) have been widely used in various applications as antimicrobial agents, anticancer, diagnostics, biomarkers, cell labels, and drug delivery systems for the treatment of various diseases. Microorganisms generally acquire resistance to antibiotics through the course of antibacterial therapy. Multi-drug resistance (MDR) has become a growing problem in the treatment of infectious diseases, and the widespread use of broad-spectrum antibiotics has resulted in the development of antibiotic resistance by numerous human and animal bacterial pathogens...
March 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28245707/standardized-extract-of-lactuca-sativa-linn-and-its-fractions-abrogates-scopolamine-induced-amnesia-in-mice-a-possible-cholinergic-and-antioxidant-mechanism
#5
Jai Malik, Jagpreet Kaur, Sunayna Choudhary
OBJECTIVES: The present study was designed to evaluate the efficacy of Lactuca sativa (LS) Linn. (Asteraceae) against scopolamine- induced amnesia and to validate its traditional claim as memory enhancer. METHODS: Ethanol extract of fresh LS leaves (LSEE), standardized on the basis of quercetin content, was successively partitioned using various solvents viz., hexane, ethyl acetate, and n-butanol in increasing order of polarity. LSEE (50, 100, and 200 mg/kg) and its various fractions (at a dose equivalent to dose of LSEE exhibiting maximum activity), administered orally for 14 days, were evaluated for their memory enhancing effect against scopolamine-induced (1 mg/kg, i...
February 28, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28237915/hepatoprotective-activity-of-butea-monosperma-bark-against-thioacetamide-induced-liver-injury-in-rats
#6
Varinder Kaur, Manish Kumar, Paramjeet Kaur, Sandeep Kaur, Amrit Pal Singh, Satwinderjeet Kaur
For thousands of years, the plant-based natural products have been a source of curative agents for various ailments. Butea monosperma (Fabaceae) has an important place in Indian traditional system of medicine for curing number of disorders. The present study deals with evaluation of hepatoprotective properties of ethyl acetate fraction (Beac) from B. monosperma bark in rat model. In preliminary antioxidant studies, Beac demonstrated pronounced superoxide scavenging (IC50 88.85μg/ml) and anti-lipid peroxidation (IC50 131...
February 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28229914/quercetin-exerts-preventive-ameliorative-and-prophylactic-effects-on-cadmium-chloride-induced-oxidative-stress-in-the-uterus-and-ovaries-of-female-wistar-rats
#7
Victor Udo Nna, Umar Zayyanu Usman, Emmanuel Oleba Ofutet, Daniel Udofia Owu
This study examined the possible protective effect of quercetin(QE) on cadmium chloride (CdCl2) - induced reproductive toxicity in female rats. Cadmium (Cd) accumulated in the uterus and ovaries of rats, decreased antioxidants [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione (GSH)], and raised the concentrations of malondialdehyde (MDA) and hydrogen peroxide (H2O2) in the uterus and ovaries of rats. Serum concentrations of estradiol, progesterone, follicle stimulating hormone and luteinizing hormone decreased significantly after CdCl2 administration...
February 14, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28213289/quercetin-and-pioglitazone-synergistically-reverse-endothelial-dysfunction-in-isolated-aorta-from-fructose-streptozotocin-f-stz-induced-diabetic-rats
#8
Thubasni Kunasegaran, Mohd Rais Mustafa, Francis I Achike, Dharmani Devi Murugan
Pioglitazone is an anti-diabetic drug with potential to cause adverse effects following prolonged use. This study, therefore, investigated the effects of combination treatment of a subliminal concentration of pioglitazone and quercetin, a potent antioxidant, on vascular reactivity of aorta isolated from fructose-streptozotocin (F-STZ)-induced diabetic rats. Relaxation to acetylcholine and sodium nitroprusside, and contraction to phenylephrine were tested in organ bath chambers following pre-incubation with vehicle (DMSO; 0...
February 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28183032/manganese-neurotoxicity-and-protective-effects-of-resveratrol-and-quercetin-in-preclinical-research
#9
Maciej Gawlik, Małgorzata B Gawlik, Irena Smaga, Małgorzata Filip
BACKGROUND: Exposure to Mn results in a neurological syndrome known as manganism. METHODS: We examined how 4-week Mn exposure (20mg/kg MnCl2po, 5days/week) induces neurotoxic effects in rats. Oxidized-to-reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), superoxide dismutase (SOD) activity, catalase (CAT) activity, vitamin E content and caspase-3 activity were measured in several rat brain structures. Further, we examined protective effects of the polyphenols: resveratrol (R) or quercetin (QCT) against Mn-induced neurotoxicity...
December 14, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28137214/phytochemical-constituents-ches-and-urease-inhibition-antiproliferative-and-antioxidant-properties-of-elaeagnus-umbellata-thunb
#10
Tevfik Ozen, Semiha Yenigun, Muhammed Altun, Ibrahim Demirtas
Due to the common ethnopharmacological used or scientifically examined biochemical properties, Elaeagnaceae family, Elaeagnus umbellata Thunb. (autumn olive) was worth investigated. In this investigation, we revealed antioxidant, antiproliferative and enzyme inhibition activities of the water, methanol, ethanol, acetone, ethyl acetate and hexane extracts of E. umbellata as well as contents of their phenolic, flavonoid, anthocyanin, ascorbic acid, lycopene and b-carotene. The antioxidant activity was screened by phosphomolybdenum assay...
January 27, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28119263/quercetin-protects-liver-injury-induced-by-bile-duct-ligation-via-attenuation-of-rac1-and-nadph-oxidase1-expression-in-rats
#11
Razieh Kabirifar, Zohreh-Al-Sadat Ghoreshi, Fatemeh Safari, Alireza Karimollah, Ali Moradi, Ebrahim Eskandari-Nasab
BACKGROUND: Bile duct ligation (BDL) and subsequent cholestasis are correlated with oxidative stress, hepatocellular injury and fibrosis. Quercetin is a flavonoid with antifibrotic, and hepatoprotective properties. However, the molecular mechanism underlying quercetin-mediated hepatoprotection is not fully understood. The current study was to evaluate mechanisms of hepatoprotective effect of quercetin in BDL rat model. METHODS: We divided male Wistar rats into 4 groups (n=8 for each): sham, sham+quercetin (30 mg/kg per day), BDL, and BDL+quercetin (30 mg/kg per day)...
February 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28115850/gold-quercetin-nanoparticles-prevent-metabolic-endotoxemia-induced-kidney-injury-by-regulating-tlr4-nf-%C3%AE%C2%BAb-signaling-and-nrf2-pathway-in-high-fat-diet-fed-mice
#12
Min-Xuan Xu, Ming Wang, Wei-Wei Yang
High-fat diet-induced metabolic syndrome followed by chronic kidney disease caused by intestinal endotoxemia have received extensive attention. Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) and oxidative stress-related Nrf2/Keap1 were regarded as the key target points involved in metabolic inflammation and kidney injury. However, the molecular mechanism of interaction between TLR4/NF-κB and Nrf2 activation in high-fat diet-induced renal injury is not absolutely understood. Quercetin, a natural product, has been reported to possess antitumor and anti-inflammatory effects...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28104348/quercetin-protects-against-heat-stroke-induced-myocardial-injury-in-male-rats-antioxidative-and-antiinflammatory-mechanisms
#13
Xiaojing Lin, Cheng-Hsien Lin, Tingbao Zhao, Dan Zuo, Zhujun Ye, Lin Liu, Mao-Tsun Lin
Heat stroke is characterized by hyperthermia, systemic inflammation, and multiple organ failure including arterial hypotension. This definition can be fulfilled by a rat model of heat stroke used in the present study. Anesthetized animals were exposed to heat exposure (43 °C for 70 min) and then returned to room temperature (26 °C) for recovery. One hour before heat exposure, an intraperitoneal dose of quercetin (30 mg/kg) or vehicle (normal saline 1 ml/kg) was administered to the experimental groups of rats...
March 1, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28043195/ameliorative-effects-of-gallic-acid-quercetin-and-limonene-on-urethane-induced-genotoxicity-and-oxidative-stress-in-drosophila-melanogaster
#14
Isha Nagpal, Suresh K Abraham
The main objective of our present work was to ascertain the efficacy of Drosophila melanogaster model for assessing antigenotoxic and antioxidant effects of dietary phytochemicals gallic acid (GA), quercetin (QC) and limonene (Lim) against urethane (URE), a genotoxic environmental carcinogen. Oregon-K (ORK) adult male flies were fed GA, QC and Lim in combination with URE (20 mM) in 10% sucrose for 72 h. Third instar larvae were fed instant medium containing the above phytochemicals and URE for 24 h. Sex-linked recessive lethal (SLRL) test and assays for estimating glutathione content (GSH), glutathione S-transferase (GST), catalase (CAT), superoxide dismutase (SOD) and lipid peroxidation (MDA content) were performed...
January 18, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28035607/beneficial-effects-of-quercetin-on-titanium-dioxide-nanoparticles-induced-spermatogenesis-defects-in-mice
#15
Layasadat Khorsandi, Mahmoud Orazizadeh, Nahid Moradi-Gharibvand, Masoud Hemadi, Esrafil Mansouri
Many recent studies have demonstrated that most nanoparticles (NPs) have an adverse or toxic action on male germ cells. In present study, protective effect of quercetin (Que) on titanium dioxide nanoparticle (NTiO2)-induced spermatogenesis defects in mice was investigated. Thirty-two Naval Medical Research Institute (NMRI) mice were randomly divided into four groups. Que group received 75 mg/kg of Que for 42 days. NTiO2 group received 300 mg/kg NTiO2 for 35 days. NTiO2 + Que group initially received 75 mg/kg Que for 7 days and was followed by concomitant administration of 300 mg/kg NTiO2 for 35 days...
December 29, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28033106/protective-effects-of-quercetin-and-vitamin-c-against-nicotine-induced-toxicity-in-the-blood-of-wistar-rats
#16
Milica G Paunović, Branka I Ognjanović, Miloš M Matić, Andraš Š Štajn, Zorica S Saičić
Nicotine is a potential inducer of oxidative stress, through which it can damage numerous biological molecules. The aim of our study was to investigate the prooxidative effects of nicotine and protective (additive or synergistic) effects of quercetin and vitamin C in the blood of experimental animals, to determine whether the combination of these antioxidants might be beneficial for clinical purposes. Wistar albino rats were receiving intraperitoneal nicotine injection (0.75 mg kg-1 per day) or saline (control group) or nicotine plus quercetin (40 mg kg-1 per day) and vitamin C (100 mg kg-1 per day) for three consecutive days...
December 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/27832996/quercetin-changes-purinergic-enzyme-activities-and-oxidative-profile-in-platelets-of-rats-with-hypothyroidism
#17
Jucimara Baldissarelli, Adriana Santi, Roberta Schmatz, Daniela Zanini, Andréia M Cardoso, Fátima H Abadalla, Gustavo R Thomé, Camila Murussi, Carla R N Polachini, Diéssica P Delenogare, Vania L Loro, Vera M Morsch, Maria R C Schetinger
Diseases related to thyroid hormones have been extensively studied because affect a large number of individuals, and these hormones participate in the regulation of the whole organism homeostasis. However, little is known about the involvement of purinergic signaling related to oxidative stress in hypothyroidism and possible therapeutic adjuncts for treatment of this disorder. Thus, the present study investigates the effects of quercetin on NTPDase, 5'-nucleotidase and adenosine deaminase activities, platelet aggregation and oxidative profile in platelets of rats with methimazole (MMI)-induced hypothyroidism...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27801831/antioxidant-enzyme-activities-and-lipid-oxidation-in-rape-brassica-campestris-l-bee-pollen-added-to-salami-during-processing
#18
Yawei Zhang, Fengtian Yang, Muneer Ahmed Jamali, Zengqi Peng
The present research investigated the antioxidant effect of rape (Brassica campestris L.) bee pollen (RBP) on salami during processing. Eight flavonoids in RBP ethanol extract were quantified by high-performance liquid chromatography-mass spectrometry (HPLC-MS) analysis, and quercetin, rutin, and kaempferol were the major bioactive compounds. The RBP ethanol extract exhibited higher total antioxidant capacity than 6-hydroxy-2,5,7,8-tertramethylchromancarboxylic acid (trolox) at the same concentration. The salami with 0...
October 28, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27796749/quercetin-exerts-differential-neuroprotective-effects-against-h2o2-and-a%C3%AE-aggregates-in-hippocampal-neurons-the-role-of-mitochondria
#19
Juan A Godoy, Carolina B Lindsay, Rodrigo A Quintanilla, Francisco J Carvajal, Waldo Cerpa, Nibaldo C Inestrosa
Amyloid-β peptide (Aβ) is one of the major players in the pathogenesis of Alzheimer's disease (AD). Despite numerous studies, the mechanisms by which Aβ induces neurodegeneration are not completely understood. Oxidative stress is considered a major contributor to the pathogenesis of AD, and accumulating evidence indicates that high levels of reactive oxygen species (ROS) are involved in Aβ-induced neurodegeneration. Moreover, Aβ can induce the deregulation of calcium homeostasis, which also affects mitochondrial function and triggers neuronal cell death...
October 28, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27780244/protective-effects-of-quercetin-on-mitochondrial-biogenesis-in-experimental-traumatic-brain-injury-via-the-nrf2-signaling-pathway
#20
Xiang Li, Handong Wang, Yongyue Gao, Liwen Li, Chao Tang, Guodao Wen, Yuan Zhou, Mengliang Zhou, Lei Mao, Youwu Fan
The present investigation was carried out to elucidate a possible molecular mechanism related to the protective effect of quercetin administration against oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in mitochondrial biogenesis. Recently, quercetin has been proved to have a protective effect against mitochondria damage after traumatic brain injury (TBI). However, its precise role and underlying mechanisms in traumatic brain injury are not yet fully understood...
2016: PloS One
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