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Superoxide AND Quercetin

Jiao Wang, Xin Qian, Qiang Gao, Chunmei Lv, Jie Xu, Hongbo Jin, Hui Zhu
BACKGROUND: Menopause is the most important sign of aging in women, and the ovary is the organ most sensitive to aging. Quercetin is a potential antioxidant and free radical scavenger that is widely found in fruits, vegetables, and leaves. However, the effect of quercetin on ovarian aging has not been elucidated, and the mechanism underlying its antioxidative effect remains unclear. The purpose of the current study was to investigate whether quercetin protects ovarian function by decreasing oxidative stress...
June 21, 2018: Journal of Ovarian Research
Mohammad-Reza Khajevand-Khazaei, Parvaneh Mohseni-Moghaddam, Marjan Hosseini, Leila Gholami, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Acute kidney injury (AKI) is a common complication following severe sepsis, its incidence is increasing, and it is associated with a high rate of morbidity and mortality. Rutin is a glycoside of the bioflavonoid quercetin with various protective effects due to its antioxidant and anti-inflammatory potential. In this research, we tried to assess the protective effect of rutin administration in a model of AKI in C57BL/6 mice. For induction of AKI, lipopolysaccharide (LPS) was injected once (10mg/kg, i.p.) and rutin was p...
June 16, 2018: European Journal of Pharmacology
Fabiano B Carvalho, Jessié M Gutierres, Diego Beckmann, Rosmarini P Santos, Gustavo R Thomé, Jucimara Baldissarelli, Naiara Stefanello, Amanda Andrades, Graciane Aiello, Angel Ripplinger, Bruna M Lucio, Rafael Ineu, Alexandre Mazzanti, Vera Morsch, Maria Rosa Schetinger, Cinthia M Andrade
Quercetin is reported to exert a plethora of health benefits through many different mechanisms of action. This versatility and presence in the human diet has attracted the attention of the scientific community, resulting in a huge output of in vitro and in vivo (preclinical) studies. Therefore, we hypothesized that quercetin can protect Na+ ,K+ -ATPase activity in the central nervous system, reestablish the peripheral cholinesterases activities, and reduce oxidative stress during demyelination events in rats...
July 2018: Nutrition Research
Wen-Juan Wang, Wen-Jie Wei, Rong-Zhen Liao
The reaction mechanism and chemoselectivity of nickel-dependent quercetin 2,4-dioxygenase (2,4-QueD) have been investigated using the QM/MM approach. The protonation state of the Glu74 residue, a first-shell ligand of Ni, has been considered to be either neutral or deprotonated. QM/MM calculations predict that Glu74 must be deprotonated to rationalize the chemoselectivity and steer the 2,4-dioxygenolytic cleavage of quercetin, which harvests the experimentally-observed product, 2-protocatechuoylphloroglucinol carboxylic acid, coupled with the release of carbon monoxide...
June 5, 2018: Physical Chemistry Chemical Physics: PCCP
Sooad Saud Al-Otaibi, Maha Mohamad Arafah, Bechan Sharma, Abdullah Salih Alhomida, Nikhat Jamal Siddiqi
Objectives: The present study was carried out to study the protective effects of quercetin and α -lipoic acid alone and in combination against aluminum chloride induced neurotoxicity in rats. Materials and Methods: The study consisted of eight groups, namely, Group 1: control rats, Group 2: rats receiving aluminium chloride 7 mg/kg body weight intraperitoneal route (i.p) for two weeks, Group 3: rats receiving quercetin 50 mg/kg body weight i.p. for two weeks, Group 4: rats receiving quercetin 50 mg/kg body weight followed by aluminium chloride 7 mg/kg body weight i...
2018: Journal of Toxicology
Shanshan Li, Hui Cao, Dingzhu Shen, Qingling Jia, Chuan Chen, San Li Xing
Quercetin is a flavonoid that has anti‑inflammatory, anti‑oxidant and lipid metabolic effects. It has also been reported to reduce the risk of cardiovascular disease. The present study measured the effects of quercetin on the expression of ATP‑binding cassette transporter 1 (ABCAl), ATP‑binding cassette sub‑family G member 1 (ABCG1), liver X receptor‑α (LXR‑α), proprotein convertase subtilisin/kexin type 9 (PCSK9), p53, p21 and p16 induced by oxidized low density lipoprotein (ox‑LDL). RAW264...
May 22, 2018: Molecular Medicine Reports
Iman O Sherif
Hepatotoxicity induced by cyclophosphamide (Cyclo) is a major concern in clinical practice. This study was designed to investigate the possible cytoprotective effect of natural antioxidants as oleuropein and quercetin against Cyclo induced hepatotoxicity via the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. Male Wistar rats were randomly divided into six groups and treated for 10 days as follow: Group I (Normal control) received saline, group II (Oleu control): received orally oleuropein 30 mg/kg/day, group III (Quer control): administered orally quercetin 50 mg/kg/day, group IV (Cyclo): received saline and injected with single intraperitoneal (i...
May 22, 2018: International Immunopharmacology
Gollapalle Lakshminarayanashastry Viswanatha, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasad, Shylaja Hanumanthappa
ETHNOPHARMACOLOGICAL RELEVANCE: Colebrookea oppositifolia Smith is one of the extensively used plants to treat neurological conditions such as epilepsy by the various ethnic communities in sub-Himalayan regions of India such as Bhoxa, Tharu and nomadic Gujjars. AIM OF THE STUDY: This study was conducted to evaluate the cerebroprotective effect of C. oppositifolia methanolic root (MeCO) extract in Wistar rats. MATERIALS AND METHODS: The MeCO was characterized for total phenolic content and later subjected for detailed liquid chromatography-mass spectrometry analysis...
May 16, 2018: Journal of Ethnopharmacology
Iman O Sherif
The urotoxicity is a common complication associated with patients receiving cyclophosphamide (CYP). This study was designed to investigate the uroprotective mechanism of quercetin (Quer) flavonoid against CYP induced urotoxicity via determination of oxidative stress markers as well as inflammatory mediators in bladder tissue. Forty male Wistar rats were divided into four groups; Normal group: received saline for 10 days. Quer control group: received quercetin 50 mg/kg/day for 10 days. CYP group: received saline for 10 days and injected with a single dose of 150 mg/kg CYP intraperitoneal (i...
May 18, 2018: Journal of Cellular Biochemistry
Eun-Ju Sohn, Jung Min Kim, Se-Hui Kang, Joseph Kwon, Hyun Joo An, Jung-Suk Sung, Kyung A Cho, Ik-Soon Jang, Jong-Soon Choi
The oxidative damage initiated by reactive oxygen species (ROS) is a major contributor to the functional decline and disability that characterizes aging. The anti-oxidant flavonoid, quercetin, is a plant polyphenol that may be beneficial for retarding the aging process. We examined the restoring properties of quercetin on human dermal fibroblasts (HDFs). Quercetin directly reduced either intracellular or extracellular ROS levels in aged HDFs. To find the aging-related target genes by quercetin, microarray analysis was performed and two up-regulated genes LPL and KCNE2 were identified...
May 8, 2018: American Journal of Chinese Medicine
Chengyu Tan, Fantong Meng, E Albert Reece, Zhiyong Zhao
BACKGROUND: Diabetes mellitus in early pregnancy increases the risk of birth defects in infants. Maternal hyperglycemia stimulates the expression of nitric oxide (NO) synthase 2 (NOS2), which can be regulated by transcription factors of the nuclear factor-κB (NF-κB) family. Increases in reactive nitrogen species (RNS) generate intracellular stress conditions, including nitrosative, oxidative, and endoplasmic reticulum (ER) stresses, and trigger programmed cell death (or apoptosis) in the neural folds, resulting in neural tube defects (NTDs) in the embryo...
May 4, 2018: American Journal of Obstetrics and Gynecology
Ting-Ting Zhao, Tian-Lun Yang, Li Gong, Pei Wu
To unveil the possible protective role of isorhamnetin, an immediate 3'-O-methylated metabolite of quercetin, in cardiomyocyte under hypoxia/reoxygenation (H/R) condition and the underlying mechanisms involved, H9c2 cardiomyocytes were exposed to the vehicle or H/R for 6 h (2 h of hypoxia following by 4 h of reoxygenation) with isorhamnetin (0, 3, 6, 12, 25, 50 μM for 4 h prior to H/R exposure). Apoptosis was evaluated by TUNEL staining, flow cytometry analysis and western blot assay for cleaved caspase-3...
May 3, 2018: Gene
Nelly Rivera-Yañez, Mario Rodriguez-Canales, Oscar Nieto-Yañez, Manuel Jimenez-Estrada, Maximiliano Ibarra-Barajas, M M Canales-Martinez, M A Rodriguez-Monroy
Propolis is a bee-collected natural product that has been proven to have various bioactivities. This study tested the effects of a Mexican propolis on streptozotocin-induced diabetes mellitus in a murine model. The results showed that an ethanolic extract of propolis of Chihuahua (EEPCh) significantly inhibited increases in blood glucose and the loss of body weight in diabetic mice. EEPCh increased plasma insulin levels in STZ-diabetic mice, whereas, in untreated diabetic mice, there was no detection of insulin...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Ketan Vinayakrao Hatware, Sanjay Sharma, Kiran Patil, Meghanath Shete, Sravani Karri, Gaurav Gupta
The Cordia dichotoma (CD) is having anticancer and other pharmacological effects as it contains mainly flavonoids. The present study was aimed to demonstrate the gastroprotective effect of methanolic extract of CD leaves (MECD) obtained using Soxhlet extractor. In this study the qualitative phytochemical analysis of MECD revealed the presence of bioflavonoids and determination of quercetin was confirmed by HPLC analysis. The MECD was administered orally at doses 50 mg/kg, 100 mg/kg and 200 mg/kg against indomethacin induced gastric ulceration and stress-induced gastric ulceration in Wistar rats...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Valeria Calabró, María C Litterio, Cesar G Fraga, Monica Galleano, Barbara Piotrkowski
This study investigated the effects of a quercetin-supplemented diet on the biochemical changes installed in the heart of NO-deficient rats in terms of oxidants production and NO bioavailability determinants. Sprague-Dawley rats were subjected to Nω -nitro-l-arginine methyl ester (l-NAME) treatment (360 mg/L l-NAME in the drinking water, 4 d) with or without supplementation with quercetin (4 g/kg diet). l-NAME administration led to increased blood pressure (BP) (30%), decreased nitric oxide synthase (NOS) activity (50%), and increases in NADPH oxidase (NOX)-dependent superoxide anion production (60%) and p47phox protein level (65%)...
June 1, 2018: Archives of Biochemistry and Biophysics
Syeda Tayyaba Batool Kazmi, Muhammad Majid, Sonia Maryam, Aymen Rahat, Madiha Ahmed, Muhammad Rashid Khan, Ihsan Ul Haq
Quercus dilatata Lindl. ex Royle was evaluated for in vitro polyphenol content and antioxidant potential as well as in vivo protective role against bisphenol A (BPA) induced hepatotoxicity. The distilled water-acetone (QDDAE) and methanol-ethyl acetate (QDMEtE) extracts were standardized and administered in high (300 mg/kg body weight (BW) and low (150 mg/kg BW) doses to Sprague Dawley rats, injected with BPA (25 mg/kg BW). Silymarin (50 mg/kg BW) was used as positive control. Subsequently, blood and liver homogenates were collected after four weeks of treatment, and the defensive effects of both extracts against oxidative damage and genotoxicity were assessed via hematological and biochemical investigations, determination of endogenous expression of enzymes as well as levels of free radicals and comet assay...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yu-Jing Zhao, Jian-Kuan Li, Xin Zhang, Jian-Ping Gao
The present study is to study the chemical constituents from ethanol extract of Psidium guajava leaves. The constituents were separated and purified by silica gel column chromaiographios over, macroporous resin D-101, Sephadex LH-20, and ODS. Six flavonoids compounds were isolated and identified as quercetin(1), quercetin-3- O - α -D-arabinopyranoside(2), quercetin-3- O - α -D-ribopyranoside(3), quercetin-3- O - β -D-galactopyranoside(4), quercetin-3- O - α -D-glucopyranoside(5), and quercetin-3- O - α- D-xylpyranoside(6)...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Dikonketso Cathrine Bodiba, Preety Prasad, Ajay Srivastava, Brigdet Crampton, Namrita Sharan Lall
Background: Curative plants have reportedly been used to make chewing sticks/toothbrushes intended for the treatment of oral diseases. Objective: The in vitro antibacterial activities of Azadirachta indica , Pongamia pinnata , Psidium guajava , and Mangifera indica were evaluated against Streptococcus mutans , along with the cytotoxicity and antioxidant and synergistic potentials. The effect of M. indica on the expression of crucial virulence genes spaP and gtfB of S...
January 2018: Pharmacognosy Magazine
Sibel Türedi, Esin Yuluğ, Ahmet Alver, Akin Bodur, İmran İnce
The present study evaluated the neuroprotective and antioxidant effects of quercetin in a rat model of sciatic nerve crush injury using histopathological, morphometric and biochemical methods. A total of 48 male Sprague Dawley rats, aged 10-12 weeks old were randomly divided into eight groups, consisting of two sham groups (S-7, S-28), three quercetin-treated groups (Q-7, Q-28; 200 mg/kg/7 days), trauma (T-7, T-28; 1 min sciatic nerve crush injury) and three trauma+quercetin groups (T+Q-7, T+Q-28; trauma+quercetin 200 mg/kg/7 days)...
April 2018: Experimental and Therapeutic Medicine
Phaniendra Alugoju, Vkd Krishan Swamy, Latha Periyasamy
Aging is characterized by gradual accumulation of macromolecular damage leading to progressive loss of physiological function and increased susceptibility to diverse diseases. Effective anti-aging strategies involving caloric restriction or antioxidant supplementation are receiving growing attention to attenuate macromolecular damage in age associated pathology. In the present study, we for the first time investigated the effect of quercetin, caloric restriction and combined treatment (caloric restriction with quercetin) on oxidative stress parameters, acetylcholinesterase and ATPases enzyme activities in the cerebral cortex of aged male wistar rat brain...
March 14, 2018: CNS & Neurological Disorders Drug Targets
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