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Superoxide AND Quercetin

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https://www.readbyqxmd.com/read/29205806/neuroprotection-by-quercetin-via-mitochondrial-function-adaptation-in-traumatic-brain-injury-pgc-1%C3%AE-pathway-as-a-potential-mechanism
#1
Xiang Li, Handong Wang, Guodao Wen, Liwen Li, Yongyue Gao, Zong Zhuang, Mengliang Zhou, Lei Mao, Youwu Fan
The aim of this study was to investigate the neuroprotective effects of quercetin in mouse models of traumatic brain injury (TBI) and the potential role of the PGC-1α pathway in putative neuroprotection. Wild-type mice were randomly assigned to four groups: the sham group, the TBI group, the TBI+vehicle group and the TBI+quercetin group. Quercetin, a dietary flavonoid used as a food supplement, significantly reduced TBI-induced neuronal apoptosis and ameliorated mitochondrial lesions. It significantly accelerated the translocation of PGC-1α protein from the cytoplasm to the nucleus...
December 4, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29142401/phytochemical-compositions-and-in-vitro-assessments-of-antioxidant-and-antidiabetic-potentials-of-fractions-from-ehretia-cymosa-thonn
#2
Akintayo Ogundajo, Anofi Tom Ashafa
Background: Ehretia cymosa Thonn. is a popular medicinal plant used in different parts of West Africa for the treatment of various ailments including diabetes mellitus. Objective: The current study investigates bioactive constituents and in vitro antioxidant and antidiabetic potentials of fractions from extract of E. cymosa. Materials and Methods: Phytochemical investigation and antioxidant assays were carried out using standard procedures...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29109370/olive-olea-europaea-l-biophenols-a-nutriceutical-against-oxidative-stress-in-sh-sy5y-cells
#3
Syed Haris Omar, Philip G Kerr, Christopher J Scott, Adam S Hamlin, Hassan K Obied
Plant biophenols have been shown to be effective in the modulation of Alzheimer's disease (AD) pathology resulting from free radical-induced oxidative stress and imbalance of the redox chemistry of transition metal ions (e.g., iron and copper). On the basis of earlier reported pharmacological activities, olive biophenols would also be expected to have anti-Alzheimer's activity. In the present study, the antioxidant activity of individual olive biophenols (viz. caffeic acid, hydroxytyrosol, oleuropein, verbascoside, quercetin, rutin and luteolin) were evaluated using superoxide radical scavenging activity (SOR), hydrogen peroxide (H₂O₂) scavenging activity, and ferric reducing ability of plasma (FRAP) assays...
October 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29043342/antihypertensive-effects-of-tartary-buckwheat-flavonoids-by-improvement-of-vascular-insulin-sensitivity-in-spontaneously-hypertensive-rats
#4
Zuoxu Hou, Yuanyuan Hu, Xingbin Yang, Wensheng Chen
Vascular insulin resistance and oxidative stress contribute to endothelial dysfunction and hypertension. The present study investigated whether chronic treatment with purified Tartary buckwheat flavonoids fraction (TBF) prevents the development of hypertension via improving vascular insulin sensitivity and reducing oxidative stress. Six-week-old male spontaneously hypertensive rats (SHRs) and their normotensive Wistar-Kyoto (WKY) control rats were subjected to different dosages of TBF for 8 weeks. Blood pressure, mesenteric arteriolar vasorelaxation, superoxide anion (O2(-)) generation, NAD(P)H oxidase activity, and insulin-stimulated Akt/endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production were determined...
October 18, 2017: Food & Function
https://www.readbyqxmd.com/read/28956665/modulation-of-advanced-glycation-end-products-sorbitol-and-aldose-reductase-by-hydroalcohol-extract-of-lagenaria-siceraria-mol-standl-in-diabetic-complications-an-in-vitro-approach
#5
Anu Kajal, Randhir Singh
Herbal medicines have become a core interest, and they are used widely. Lagenaria siceraria is known for its antihyperglycemic, antidyslipidemic, antioxidant potential, and the present study was designed to explore the possible role of L. siceraria in attenuation of diabetic complications via in vitro modulation of advanced glycation end products (AGEs), sorbitol, and aldose reductase (ALR)-three major biomarkers of diabetic complications. To the best of our knowledge, no study has yet been carried out to explore L...
September 28, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28955360/combined-effects-of-elevated-o3-concentrations-and-enhanced-uv-b-radiation-of-the-biometric-and-biochemical-properties-of-soybean-roots
#6
Bing Mao, Yan Wang, Tian-Hong Zhao, Rong-Rong Tian, Wei Wang, Jia-Shu Ye
Enhanced ultraviolet-B (UV-B) radiation and elevated tropospheric ozone alone may inhibit the growth of agricultural crops. However, research regarding their combined effects on growth and biochemical properties of roots is still scarce. Using open top chambers, we monitored the response of growth, secondary metabolites, endogenous hormones and enzyme activities of soybean roots to elevated O3 and enhanced UV-B individually and in combination at stages of branching, flowering and podding. Our results indicated that the root biomass decreased by 23...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28931163/influence-of-quercetin-in-the-temporal-regulation-of-redox-homeostasis-in-drosophila-melanogaster
#7
Perumal Subramanian, Kanimozhi Kaliyamoorthy, Jaime Jacqueline Jayapalan, Puteri Shafinaz Abdul-Rahman, Onn Haji Hashim
Numerous biological processes are governed by the biological clock. Studies using Drosophila melanogaster (L.) are valuable that could be of importance for their effective applications on rodent studies. In this study, the beneficial role of quercetin (a flavonoid) on H2O2 induced stress in D. melanogaster was investigated. D. melanogaster flies were divided into four groups (group I - control, group II - H2O2 (acute exposure), group III - quercetin, and group IV - quercetin + H2O2 treated). Negative geotaxis assay, oxidative stress indicators (protein carbonyls, thiobarbituric reactive substances [TBARS]), and antioxidants (superoxide dismutase [SOD], catalase [CAT], glutathione-S-transferase [GST], glutathione peroxidase, and reduced glutathione [GSH]) were measured at 4 h intervals over 24 h and temporal expression of heat shock protein-70 (Hsp70), Upd1 (homolog of IL-6 in Drosophila), and nitric oxide synthase (Nos) was analyzed by Western blotting...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28914791/quercetin-attenuates-manganese-induced-neuroinflammation-by-alleviating-oxidative-stress-through-regulation-of-apoptosis-inos-nf-%C3%AE%C2%BAb-and-ho-1-nrf2-pathways
#8
Entaz Bahar, Ji-Ye Kim, Hyonok Yoon
Manganese (Mn) is an essential trace element required for the development of human body and acts as an enzyme co-factor or activator for various reactions of metabolism. While essential in trace amounts, excessive Mn exposure can result in toxic accumulations in human brain tissue and resulting extrapyramidal symptoms called manganism similar to idiopathic Parkinson's disease (PD). Quercetin (QCT) has been demonstrated to play an important role in altering the progression of neurodegenerative diseases by protecting against oxidative stress...
September 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28911678/averrhoa-bilimbi-fruits-attenuate-hyperglycemia-mediated-oxidative-stress-in-streptozotocin-induced-diabetic-rats
#9
Surya B Kurup, S Mini
Hyperglycemia-mediated oxidative stress plays a major role in the development of diabetic complications. Averrhoa bilimbi Linn. (Oxalidaceae) is a medicinal plant with fruits reported to possess antidiabetic activity. This study evaluated the beneficial effects of the ethyl acetate fraction of A. bilimbi fruit (ABAEE) on the antioxidant/oxidant status in diabetes mellitus. Diabetic rats were treated orally with the ethyl acetate fraction of A. bilimbi fruits at a dose of 25 mg/kg body weight for 60 days. Serum glucose, glycated hemoglobin, plasma insulin, hepatic toxicity markers, antioxidant enzymes, lipid peroxidation products, and liver histopathology were assayed checked after 60 days of extract treatment...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28840624/chemical-composition-and-antioxidant-antinociceptive-and-anti-inflammatory-activities-of-four-amazonian-byrsonima-species
#10
Fernanda Guilhon-Simplicio, Tallita Marques Machado, Leandro Flores do Nascimento, Rayanne da Silva Souza, Hector Henrique Ferreira Koolen, Felipe Moura Araújo da Silva, Leonard Domingo Rosales Acho, Adair Roberto Soares Dos Santos, Paul Cos, Maria de Meneses Pereira, Emerson Silva Lima
Species of the Byrsonima genus are widely used in Brazil, especially for the treatment of gastrointestinal disorders. However, species from the Amazonian region are still poorly studied. Thus, we studied the antioxidant, antinociceptive, and anti-inflammatory activities of for Amazonian species, Byrsonima crispa, Byrsonima duckeana, Byrsonima garcibarrigae, and Byrsonima incarnata. Phenolic composition was determined by chemical and chromatographic methods. The aqueous extracts were evaluated in DPPH(•) , ABTS(+•) , and superoxide (O2(•-) ) tests, LPS-activated macrophage assay, and formalin test...
August 25, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28836867/effects-of-ciprofloxacin-on-fetal-rat-liver-during-pregnancy-and-protective-effects-of-quercetin
#11
Z Dogan, H Elbe, E Taslidere, H Soysal, A Cetin, S Demirtas
Urinary tract infections are common in pregnant women and ciprofloxacin frequently is used as a broad spectrum antibiotic. It has been suggested that ciprofloxacin causes liver damage in fetuses. Quercetin is a flavonoid with antioxidant properties. We investigated the efficacy of quercetin treatment for preventing fetal liver damage caused by ciprofloxacin. Pregnant rats were divided into four groups: untreated control group (C), 20 mg/kg quercetin for 21 days group (Q), 20 mg/kg twice/day ciprofloxacin for 10 days group (CP), and 20 mg/kg, ciprofloxacin + quercetin for 21 days group (CP + Q)...
August 24, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28827964/antioxidant-and-antiproliferative-activity-of-asparagopsis-taxiformis
#12
P V Neethu, K Suthindhiran, M A Jayasri
BACKGROUND: Asparagopsis taxiformis (Rhodophyta) is a species of red algae belonging to the family Bonnemaisoniaceae. The objective of the present study was to evaluate antioxidant and antiproliferative activity of four fractions (petroleum ether, chloroform, ethyl acetate, and methanol) of A. taxiformis. MATERIALS AND METHODS: The red seaweed, A. taxiformis was collected from Mandapam Coastal Region, Gulf of Mannar, Tamil Nadu. Epiphytes present in algal extracts were cleaned and washed with seawater and fresh water...
July 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28815233/the-protective-effect-of-acerola-malpighia-emarginata-against-oxidative-damage-in-human-dermal-fibroblasts-through-the-improvement-of-antioxidant-enzyme-activity-and-mitochondrial-functionality
#13
José M Alvarez-Suarez, Francesca Giampieri, Massimiliano Gasparrini, Luca Mazzoni, Celestino Santos-Buelga, Ana M González-Paramás, Tamara Y Forbes-Hernández, Sadia Afrin, Timothy Páez-Watson, José L Quiles, Maurizio Battino
Acerola fruits (Malpighia emarginata DC.) from the central region of Cuba were analyzed to determine their chemical composition and protective capacity against oxidative damage using an in vitro human dermal fibroblast (HDFa) model. The chemical composition analyses showed a high content of vitamin C, total polyphenols, β-carotene and folates in the acerola fruit. From the HPLC-DAD/ESI-MS(n) analyses, two anthocyanins (cyanidin 3-O-rhamnoside and pelargonidin 3-O-rhamnoside), three hydroxycinnamoyl derivatives (caffeoyl hexoside, dihydrocaffeoylquinic acid and coumaroyl hexoside) and fifteen flavonols (mostly glycosylated forms of quercetin and kaempferol) were detected...
September 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28811686/influence-of-the-flavonoid-quercetin-on-antioxidant-status-lipid-peroxidation-and-histopathological-changes-in-hyperammonemic-rats
#14
Sivamani Kanimozhi, Pakkiri Bhavani, Perumal Subramanian
We have studied the ability of quercetin (a bioflavonoid) in tackling oxidative stress to alleviate the symptoms during ammonium chloride-induced hyperammonemia. Hyperammonemia was induced by the treatment of ammonium chloride (AC) 100 mg/kg b.w for 56 days. Hyperammonemic rats exhibited reduced urea (in plasma) and increased ammonia (in blood), uric acid (in plasma), creatinine (in serum), oxidative stress markers (thiobarbituric acid reactive substances (TBARS) and hydroperoxides (HP) and decreased levels of antioxidants (enzymatic and non-enzymatic) superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) in plasma and tissues (liver and brain) vitamins E and C (in plasma))...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28778044/role-of-phenolic-compounds-during-antioxidative-responses-of-winter-triticale-to-aphid-and-beetle-attack
#15
Paweł Czerniewicz, Hubert Sytykiewicz, Roma Durak, Beata Borowiak-Sobkowiak, Grzegorz Chrzanowski
One of the earliest responses of plants to insects' attack is generation of reactive oxygen species. However, the elevated level of ROS can elicit oxidative burst within plant tissues, and plants employ antioxidant systems against these radicals. Due to their chemical structures, polyphenols are able to diminish the level of ROS. Thus, we investigated the role of phenolic compounds in oxidative stress within winter triticale caused by Sitobion avenae and Oulema melanopus. It was found, that infestation by insects induced a high increase in the content of hydrogen peroxide and superoxide anion radical within resistant Lamberto cv...
July 29, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28756368/cadmium-chloride-induced-testicular-toxicity-in-male-wistar-rats-prophylactic-effect-of-quercetin-and-assessment-of-testicular-recovery-following-cadmium-chloride-withdrawal
#16
Victor U Nna, Godwin A Ujah, Mahaneem Mohamed, Kingsley B Etim, Benedict O Igba, Ele R Augustine, Eme E Osim
This study assessed the effect of quercetin (QE) on cadmium chloride (CdCl2) - induced testicular toxicity, as well as the effect of withdrawal of CdCl2 treatment on same. Thirty male Wistar rats aged 10 weeks old and weighing 270-300g were assigned into 5 groups and used for this study. Rats in groups 1-4 were administered vehicle, CdCl2 (5mg/kg bwt), CdCl2+QE (5mg/kg bwt and 20mg/kg bwt, respectively) or QE (20mg/kg bwt) orally for 4 weeks. Group 5 rats received CdCl2, with 4 weeks recovery period. Results showed that cadmium accumulated in serum, testis and epididymis, decreased body weight, testicular and epididymal weights, sperm count, motility and viability...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28714319/protective-effect-of-teucrium-polium-on-carbon-tetrachloride-induced-genotoxicity-and-oxidative-stress-in-rats
#17
Fatma Rahmouni, Mongi Saoudi, Nahed Amri, Abdelfattah El-Feki, Tarek Rebai, Riadh Badraoui
This study aimed to investigate the protective effects of Teucrium polium (TP) on carbon tetrachloride (CCl4) induced spleen, erythrocyte's oxidative stress, and genotoxicity in rats. TP was found to contain large amounts of polyphenols (150 mg GAE/G of dry plant) and flavonoids (60 mg QE/g of quercetin dry plant). The CCl4 (0.5 ml/kg) treated rats exhibited significant reductions in serum vitamin A (VA), vitamin E (VE) and total antioxidant status (TAS). Thiobarbituric acid reactive substances (TBARS) and conjugated dienes (CD) were significantly high in the CCl4 group compared to controls...
July 16, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28711978/the-activity-of-the-antioxidant-defense-system-of-the-weed-species-senna-obtusifolia-l-and-its-resistance-to-allelochemical-stress
#18
Érica Marusa Pergo Coelho, Mauro Cezar Barbosa, Márcio Shigueaki Mito, Gislaine Cristiane Mantovanelli, Rubem Silvério Oliveira, Emy Luiza Ishii-Iwamoto
Senna obtusifolia L., a common weed in the tropical and subtropical regions of the world, is able to germinate under adverse environmental conditions, suggesting that this species has efficient stress-adaptation strategies. The aims of the present work were to examine the energy metabolism and the antioxidant defense system of the Senna obtusifolia L. during seed germination and initial growth, and the responses to allelochemical-induced stress. Respiratory activity, the activities of alcohol dehydrogenase (ADH), superoxide dismutase (SOD), catalase (CAT),guaicol peroxidase (POD), ascorbate peroxidase (APX), glutathione reductase (GR), lipoxygenase (LOX) and the content of malondialdehyde (MDA) and glutathione (GSSG and GSH) were measured...
July 15, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28691026/quercetin-attenuates-vascular-calcification-through-suppressed-oxidative-stress-in-adenine-induced-chronic-renal-failure-rats
#19
Xue-Ying Chang, Lei Cui, Xing-Zhi Wang, Lei Zhang, Dan Zhu, Xiao-Rong Zhou, Li-Rong Hao
BACKGROUND: This study investigated whether quercetin could alleviate vascular calcification in experimental chronic renal failure rats induced by adenine. METHODS: 32 adult male Wistar rats were randomly divided into 4 groups fed normal diet, normal diet with quercetin supplementation (25 mg/kg·BW/d), 0.75% adenine diet, or adenine diet with quercetin supplementation. All rats were sacrificed after 6 weeks of intervention. Serum renal functions biomarkers and oxidative stress biomarkers were measured and status of vascular calcification in aorta was assessed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28684704/protective-effect-of-quercetin-against-oxidative-stress-induced-cytotoxicity-in-rat-pheochromocytoma-pc-12-cells
#20
Dengke Bao, Jingkai Wang, Xiaobin Pang, Hongliang Liu
Oxidative stress has been implicated in the pathogenesis of many kinds of neurodegenerative disorders, particularly Parkinson's disease. Quercetin is a bioflavonoid found ubiquitously in fruits and vegetables, and has antioxidative activity. However, the underlying mechanism of the antioxidative effect of quercetin in neurodegenerative diseases has not been well explored. Here, we investigated the antioxidative effect and underlying molecular mechanisms of quercetin on PC-12 cells. We found that PC-12 cells pretreated with quercetin exhibited an increased cell viability and reduced lactate dehydrogenase (LDH) release when exposed to hydrogen peroxide (H₂O₂)...
July 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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