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Superoxide AND Quercetin

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https://www.readbyqxmd.com/read/29410028/mechanistic-insights-into-the-inhibition-of-quercetin-on-xanthine-oxidase
#1
Cen Zhang, Rui Wang, Guowen Zhang, Deming Gong
Quercetin, one of the most abundant flavonoid in the daily diet, was found to reversibly inhibit the generation of uric acid and superoxide radicals (O2-)catalyzed by xanthine oxidase (XOD) in a mixed-type manner with IC50 values of (2.74±0.04)×10-6 and (2.90±0.03)×10-6molL-1, respectively, and the inhibition of quercetin on O2- generation may be ascribed to the reduced form of XOD by a ping-pong mechanism. XOD had one high affinity binding site for quercetin with a binding constant of 4.28×104Lmol-1 at 298K, and the binding process was predominately driven by van der Waals forces and hydrogen bonds on account of the negative enthalpy and entropy changes...
January 31, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29399294/topical-or-oral-treatment-of-peach-flower-extract-attenuates-uv-induced-epidermal-thickening-matrix-metalloproteinase-13-expression-and-pro-inflammatory-cytokine-production-in-hairless-mice-skin
#2
Chung Shil Kwak, Jiwon Yang, Chang-Yup Shin, Jin Ho Chung
BACKGROUND/OBJECTIVES: Ultraviolet radiation (UV) is a major cause of skin photoaging. Previous studies reported that ethanol extract (PET) of Prunus persica (L.) Batsch flowers (PPF, peach flowers) and its subfractions, particularly the ethylacetate (PEA) and n-butanol extracts (PBT), have potent antioxidant activity and attenuate the UV-induced matrix metalloproteinase (MMP) expression in human skin cells. In this study, we investigated the protective activity of PPF extract against UV-induced photoaging in a mouse model...
February 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29398409/oroxylum-indicum-root-bark-extract-prevents-doxorubicin-induced-cardiac-damage-by-restoring-redox-balance
#3
Seema Menon, Lincy Lawrence, Vipin P Sivaram, Jose Padikkala
BACKGROUND: Oroxylum indicum Vent., a Dasamula plant used in Ayurveda possesses antioxidant properties. OBJECTIVES: To evaluate the cardioprotective effect of 70% methanolic extract of O. indicum Vent. root bark (OIM) against doxorubicin induced cardiomyopathy in female Sprague Dawley rats. MATERIALS AND METHODS: Cardiotoxicity was induced by intra-peritoneal injection of doxorubicin 30 mg/kg body weight (b.w.) for 4 consecutive days after a ten-day pre-treatment of animals with OIM at 200 mg/kg b...
February 2, 2018: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29397540/protective-effects-of-quercetin-against-cadmium-chloride-induced-oxidative-injury-in-goat-sperm-and-zygotes
#4
Tingchao Mao, Chengquan Han, Biao Wei, Lu Zhao, Qing Zhang, Ruizhi Deng, Jun Liu, Yan Luo, Yong Zhang
Quercetin, a plant-derived flavonoid, is frequently used as an antioxidant for efficient anti-oxidative capacity. However, whether quercetin has protective effects on goat sperm and preimplantation embryos against Cd2+-induced oxidative injury is still unclear. So, we researched the influence of quercetin on goat sperm and zygotes respectively under the oxidative stress induced by Cd2+. In our study, quercetin decreased the malonaldehyde (MDA) and reactive oxygen species (ROS) levels caused by Cd2+ in goat sperm (p < 0...
February 4, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29389576/hepatoprotective-effect-of-the-ethanol-extract-of-polygonum-orientale-on-carbon-tetrachloride-induced-acute-liver-injury-in-mice
#5
Yung-Jia Chiu, Shen-Chieh Chou, Chuan-Sung Chiu, Chun-Pin Kao, Kun-Chang Wu, Chao-Jung Chen, Jen-Chieh Tsai, Wen-Huang Peng
Polygonum orientale L. (Polygonaceae) fruits have various medicinal uses, but their hepatoprotective effects have not yet been studied. This study investigated the hepatoprotective activity of the ethanolic extract of P. orientale (POE) fruits against carbon tetrachloride (CCl4)-induced acute liver injury (ALI). Mice were pretreated with POE (0.1, 0.5, and 1.0 g/kg) or silymarin (0.2 g/kg) for 5 consecutive days and administered a dose of 0.175% CCl4 (ip) on the 5th day to induce ALI. Blood and liver samples were collected to measure antioxidative activity and cytokines...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29339254/design-synthesis-biological-evaluation-and-docking-studies-of-new-3-4-5-dihydro-1h-pyrazol-isoxazol-5-yl-2-phenyl-1h-indole-derivatives-as-potent-antioxidants-and-15-lipoxygenase-inhibitors
#6
Haydi Saher ElBordiny, Mostafa Mahmoud El-Miligy, Shaymaa Emam Kassab, Hoda Daabees, Soad Abdelhamid Mohamed El-Hawash, Waleed Ali Mohamed Ali
New candidates of 3-(4,5-dihydro-1H-pyrazol/isoxazol-5-yl)-2-phenyl-1H-indole derivatives (4-7) were designed combining the pyrazoline/isoxazoline heterocycles and 2-phenylindole to explore its potential as 15-lipoxygenase (15-LOX) inhibitors. The design of the new derivatives was based on utilizing the antioxidant properties of pyrazoline, 2-phenylindole and the good 15-LOX inhibition properties of indolylpyrazoline. The derivatives were synthesized adopting simple and laboratory friendly reaction conditions to give the target compounds in quantitative yields...
January 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29334211/curcumin-and-quercetin-ameliorated-cypermethrin-and-deltamethrin-induced-reproductive-system-impairment-in-male-wistar-rats-by-upregulating-the-activity-of-pituitary-gonadal-hormones-and-steroidogenic-enzymes
#7
Poonam Sharma, Irshad Aslam Khan, Rambir Singh
Background: Dietary antioxidants protect tissues and organs against insecticides/xenobiotic-induced damage. In the present study, we evaluated the results of exposure to synthetic pyrethroid insecticides, cypermethrin (Cyp) and deltamethrin (Del) and possible protective effects of curcumin and quercetin on reproductive system in male Wistar rats. MATERIALS AND METHODS: In this controlled experimental study, 42 male Wistar rats were randomly divided into 7 groups of 6 animals...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29333386/antioxidant-and-anti-adipogenic-activities-of-trapa-japonica-shell-extract-cultivated-in-korea
#8
DooJin Lee, Ok-Hwan Lee, Geunpyo Choi, Jong Dai Kim
Trapa japonica shell contains phenolic compounds such as tannins. Studies regarding the antioxidant and anti-adipogenic effects of Trapa japonica shell cultivated in Korea are still unclear. Antioxidant and anti-adipogenic activities were measured by in vitro assays such as 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging activity, 2,2'-azinobis( 3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging activity, ferric reducing ability of plasma assay, reducing power, superoxide dismutase-like activity, and iron chelating ability in 3T3-L1 cells...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29285175/quercetin-prevents-alcohol-induced-liver-injury-through-targeting-of-pi3k-akt-nuclear-factor-%C3%AE%C2%BAb-and-stat3-signaling-pathway
#9
Minglin Zhu, Xuefeng Zhou, Jinping Zhao
Quercetin is a type of flavonoid compound, which has potent antioxidant and anti-inflammatory activities, capable of treating a variety of diseases including neurodegenerative diseases, tumors, diabetes and obesity. The present study selected alcohol-induced liver injury model mice and aimed at studying the protective role of quercetin in preventing alcohol-induced liver injury. In alcohol-induced liver injury mice treated with quercetin, it was demonstrated that levels of aspartate transaminase, alanine transaminase, total bilirubin and triglyceride were reduced...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29205806/neuroprotection-by-quercetin-via-mitochondrial-function-adaptation-in-traumatic-brain-injury-pgc-1%C3%AE-pathway-as-a-potential-mechanism
#10
Xiang Li, Handong Wang, Guodao Wen, Liwen Li, Yongyue Gao, Zong Zhuang, Mengliang Zhou, Lei Mao, Youwu Fan
The aim of this study was to investigate the neuroprotective effects of quercetin in mouse models of traumatic brain injury (TBI) and the potential role of the PGC-1α pathway in putative neuroprotection. Wild-type mice were randomly assigned to four groups: the sham group, the TBI group, the TBI+vehicle group and the TBI+quercetin group. Quercetin, a dietary flavonoid used as a food supplement, significantly reduced TBI-induced neuronal apoptosis and ameliorated mitochondrial lesions. It significantly accelerated the translocation of PGC-1α protein from the cytoplasm to the nucleus...
December 4, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29142401/phytochemical-compositions-and-in-vitro-assessments-of-antioxidant-and-antidiabetic-potentials-of-fractions-from-ehretia-cymosa-thonn
#11
Akintayo Ogundajo, Anofi Tom Ashafa
Background: Ehretia cymosa Thonn. is a popular medicinal plant used in different parts of West Africa for the treatment of various ailments including diabetes mellitus. Objective: The current study investigates bioactive constituents and in vitro antioxidant and antidiabetic potentials of fractions from extract of E. cymosa. Materials and Methods: Phytochemical investigation and antioxidant assays were carried out using standard procedures...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29109370/olive-olea-europaea-l-biophenols-a-nutriceutical-against-oxidative-stress-in-sh-sy5y-cells
#12
Syed Haris Omar, Philip G Kerr, Christopher J Scott, Adam S Hamlin, Hassan K Obied
Plant biophenols have been shown to be effective in the modulation of Alzheimer's disease (AD) pathology resulting from free radical-induced oxidative stress and imbalance of the redox chemistry of transition metal ions (e.g., iron and copper). On the basis of earlier reported pharmacological activities, olive biophenols would also be expected to have anti-Alzheimer's activity. In the present study, the antioxidant activity of individual olive biophenols (viz. caffeic acid, hydroxytyrosol, oleuropein, verbascoside, quercetin, rutin and luteolin) were evaluated using superoxide radical scavenging activity (SOR), hydrogen peroxide (H₂O₂) scavenging activity, and ferric reducing ability of plasma (FRAP) assays...
October 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29043342/antihypertensive-effects-of-tartary-buckwheat-flavonoids-by-improvement-of-vascular-insulin-sensitivity-in-spontaneously-hypertensive-rats
#13
Zuoxu Hou, Yuanyuan Hu, Xingbin Yang, Wensheng Chen
Vascular insulin resistance and oxidative stress contribute to endothelial dysfunction and hypertension. The present study investigated whether chronic treatment with purified Tartary buckwheat flavonoids fraction (TBF) prevents the development of hypertension via improving vascular insulin sensitivity and reducing oxidative stress. Six-week-old male spontaneously hypertensive rats (SHRs) and their normotensive Wistar-Kyoto (WKY) control rats were subjected to different dosages of TBF for 8 weeks. Blood pressure, mesenteric arteriolar vasorelaxation, superoxide anion (O2(-)) generation, NAD(P)H oxidase activity, and insulin-stimulated Akt/endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production were determined...
October 18, 2017: Food & Function
https://www.readbyqxmd.com/read/28956665/modulation-of-advanced-glycation-end-products-sorbitol-and-aldose-reductase-by-hydroalcohol-extract-of-lagenaria-siceraria-mol-standl-in-diabetic-complications-an-in-vitro-approach
#14
Anu Kajal, Randhir Singh
Herbal medicines have become a core interest, and they are used widely. Lagenaria siceraria is known for its antihyperglycemic, antidyslipidemic, antioxidant potential, and the present study was designed to explore the possible role of L. siceraria in attenuation of diabetic complications via in vitro modulation of advanced glycation end products (AGEs), sorbitol, and aldose reductase (ALR)-three major biomarkers of diabetic complications. To the best of our knowledge, no study has yet been carried out to explore L...
September 28, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28955360/combined-effects-of-elevated-o3-concentrations-and-enhanced-uv-b-radiation-of-the-biometric-and-biochemical-properties-of-soybean-roots
#15
Bing Mao, Yan Wang, Tian-Hong Zhao, Rong-Rong Tian, Wei Wang, Jia-Shu Ye
Enhanced ultraviolet-B (UV-B) radiation and elevated tropospheric ozone alone may inhibit the growth of agricultural crops. However, research regarding their combined effects on growth and biochemical properties of roots is still scarce. Using open top chambers, we monitored the response of growth, secondary metabolites, endogenous hormones and enzyme activities of soybean roots to elevated O3 and enhanced UV-B individually and in combination at stages of branching, flowering and podding. Our results indicated that the root biomass decreased by 23...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28931163/influence-of-quercetin-in-the-temporal-regulation-of-redox-homeostasis-in-drosophila-melanogaster
#16
Perumal Subramanian, Kanimozhi Kaliyamoorthy, Jaime Jacqueline Jayapalan, Puteri Shafinaz Abdul-Rahman, Onn Haji Hashim
Numerous biological processes are governed by the biological clock. Studies using Drosophila melanogaster (L.) are valuable that could be of importance for their effective applications on rodent studies. In this study, the beneficial role of quercetin (a flavonoid) on H2O2 induced stress in D. melanogaster was investigated. D. melanogaster flies were divided into four groups (group I - control, group II - H2O2 (acute exposure), group III - quercetin, and group IV - quercetin + H2O2 treated). Negative geotaxis assay, oxidative stress indicators (protein carbonyls, thiobarbituric reactive substances [TBARS]), and antioxidants (superoxide dismutase [SOD], catalase [CAT], glutathione-S-transferase [GST], glutathione peroxidase, and reduced glutathione [GSH]) were measured at 4 h intervals over 24 h and temporal expression of heat shock protein-70 (Hsp70), Upd1 (homolog of IL-6 in Drosophila), and nitric oxide synthase (Nos) was analyzed by Western blotting...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28914791/quercetin-attenuates-manganese-induced-neuroinflammation-by-alleviating-oxidative-stress-through-regulation-of-apoptosis-inos-nf-%C3%AE%C2%BAb-and-ho-1-nrf2-pathways
#17
Entaz Bahar, Ji-Ye Kim, Hyonok Yoon
Manganese (Mn) is an essential trace element required for the development of human body and acts as an enzyme co-factor or activator for various reactions of metabolism. While essential in trace amounts, excessive Mn exposure can result in toxic accumulations in human brain tissue and resulting extrapyramidal symptoms called manganism similar to idiopathic Parkinson's disease (PD). Quercetin (QCT) has been demonstrated to play an important role in altering the progression of neurodegenerative diseases by protecting against oxidative stress...
September 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28911678/averrhoa-bilimbi-fruits-attenuate-hyperglycemia-mediated-oxidative-stress-in-streptozotocin-induced-diabetic-rats
#18
Surya B Kurup, S Mini
Hyperglycemia-mediated oxidative stress plays a major role in the development of diabetic complications. Averrhoa bilimbi Linn. (Oxalidaceae) is a medicinal plant with fruits reported to possess antidiabetic activity. This study evaluated the beneficial effects of the ethyl acetate fraction of A. bilimbi fruit (ABAEE) on the antioxidant/oxidant status in diabetes mellitus. Diabetic rats were treated orally with the ethyl acetate fraction of A. bilimbi fruits at a dose of 25 mg/kg body weight for 60 days. Serum glucose, glycated hemoglobin, plasma insulin, hepatic toxicity markers, antioxidant enzymes, lipid peroxidation products, and liver histopathology were assayed checked after 60 days of extract treatment...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28840624/chemical-composition-and-antioxidant-antinociceptive-and-anti-inflammatory-activities-of-four-amazonian-byrsonima-species
#19
Fernanda Guilhon-Simplicio, Tallita Marques Machado, Leandro Flores do Nascimento, Rayanne da Silva Souza, Hector Henrique Ferreira Koolen, Felipe Moura Araújo da Silva, Leonard Domingo Rosales Acho, Adair Roberto Soares Dos Santos, Paul Cos, Maria de Meneses Pereira, Emerson Silva Lima
Species of the Byrsonima genus are widely used in Brazil, especially for the treatment of gastrointestinal disorders. However, species from the Amazonian region are still poorly studied. Thus, we studied the antioxidant, antinociceptive, and anti-inflammatory activities of for Amazonian species, Byrsonima crispa, Byrsonima duckeana, Byrsonima garcibarrigae, and Byrsonima incarnata. Phenolic composition was determined by chemical and chromatographic methods. The aqueous extracts were evaluated in DPPH(•) , ABTS(+•) , and superoxide (O2(•-) ) tests, LPS-activated macrophage assay, and formalin test...
August 25, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28836867/effects-of-ciprofloxacin-on-fetal-rat-liver-during-pregnancy-and-protective-effects-of-quercetin
#20
Z Dogan, H Elbe, E Taslidere, H Soysal, A Cetin, S Demirtas
Urinary tract infections are common in pregnant women and ciprofloxacin frequently is used as a broad spectrum antibiotic. It has been suggested that ciprofloxacin causes liver damage in fetuses. Quercetin is a flavonoid with antioxidant properties. We investigated the efficacy of quercetin treatment for preventing fetal liver damage caused by ciprofloxacin. Pregnant rats were divided into four groups: untreated control group (C), 20 mg/kg quercetin for 21 days group (Q), 20 mg/kg twice/day ciprofloxacin for 10 days group (CP), and 20 mg/kg, ciprofloxacin + quercetin for 21 days group (CP + Q)...
August 24, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
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