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Superoxide AND Quercetin

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https://www.readbyqxmd.com/read/27832996/quercetin-changes-purinergic-enzyme-activities-and-oxidative-profile-in-platelets-of-rats-with-hypothyroidism
#1
Jucimara Baldissarelli, Adriana Santi, Roberta Schmatz, Daniela Zanini, Andréia M Cardoso, Fátima H Abadalla, Gustavo R Thomé, Camila Murussi, Carla R N Polachini, Diéssica P Delenogare, Vania L Loro, Vera M Morsch, Maria R C Schetinger
Diseases related to thyroid hormones have been extensively studied because affect a large number of individuals, and these hormones participate in the regulation of the whole organism homeostasis. However, little is known about the involvement of purinergic signaling related to oxidative stress in hypothyroidism and possible therapeutic adjuncts for treatment of this disorder. Thus, the present study investigates the effects of quercetin on NTPDase, 5'-nucleotidase and adenosine deaminase activities, platelet aggregation and oxidative profile in platelets of rats with methimazole (MMI)-induced hypothyroidism...
November 7, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27801831/antioxidant-enzyme-activities-and-lipid-oxidation-in-rape-brassica-campestris-l-bee-pollen-added-to-salami-during-processing
#2
Yawei Zhang, Fengtian Yang, Muneer Ahmed Jamali, Zengqi Peng
The present research investigated the antioxidant effect of rape (Brassica campestris L.) bee pollen (RBP) on salami during processing. Eight flavonoids in RBP ethanol extract were quantified by high-performance liquid chromatography-mass spectrometry (HPLC-MS) analysis, and quercetin, rutin, and kaempferol were the major bioactive compounds. The RBP ethanol extract exhibited higher total antioxidant capacity than 6-hydroxy-2,5,7,8-tertramethylchromancarboxylic acid (trolox) at the same concentration. The salami with 0...
October 28, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27796749/quercetin-exerts-differential-neuroprotective-effects-against-h2o2-and-a%C3%AE-aggregates-in-hippocampal-neurons-the-role-of-mitochondria
#3
Juan A Godoy, Carolina B Lindsay, Rodrigo A Quintanilla, Francisco J Carvajal, Waldo Cerpa, Nibaldo C Inestrosa
Amyloid-β peptide (Aβ) is one of the major players in the pathogenesis of Alzheimer's disease (AD). Despite numerous studies, the mechanisms by which Aβ induces neurodegeneration are not completely understood. Oxidative stress is considered a major contributor to the pathogenesis of AD, and accumulating evidence indicates that high levels of reactive oxygen species (ROS) are involved in Aβ-induced neurodegeneration. Moreover, Aβ can induce the deregulation of calcium homeostasis, which also affects mitochondrial function and triggers neuronal cell death...
October 28, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27780244/protective-effects-of-quercetin-on-mitochondrial-biogenesis-in-experimental-traumatic-brain-injury-via-the-nrf2-signaling-pathway
#4
Xiang Li, Handong Wang, Yongyue Gao, Liwen Li, Chao Tang, Guodao Wen, Yuan Zhou, Mengliang Zhou, Lei Mao, Youwu Fan
The present investigation was carried out to elucidate a possible molecular mechanism related to the protective effect of quercetin administration against oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in mitochondrial biogenesis. Recently, quercetin has been proved to have a protective effect against mitochondria damage after traumatic brain injury (TBI). However, its precise role and underlying mechanisms in traumatic brain injury are not yet fully understood...
2016: PloS One
https://www.readbyqxmd.com/read/27769934/polyphenolic-glycoconjugates-from-medical-plants-of-rosaceae-asteraceae-family-protect-human-lymphocytes-against-%C3%AE-radiation-induced-damage
#5
Magdalena Szejk, Tomasz Poplawski, Joanna Sarnik, Izabela Pawlaczyk-Graja, Franciszek Czechowski, Alicja Klaudia Olejnik, Roman Gancarz, Halina Malgorzata Zbikowska
Radioprotective effects of the water-soluble polyphenolic glycoconjugates, isolated from flowers of Sanguisorba officinalis L.(SO) and Erigeron canadensis L.(EC), and from leaves of Fragaria vesca L. (FV) and Rubus plicatus Whe. Et N. E. (RP), against γ-radiation-induced toxicity in human peripheral blood lymphocytes were investigated. Cell treatment with glycoconjugates (1, 5 and 25μg/mL) prior exposure to 10/15Gy radiation resulted in concentration-dependent reduction of DNA damage including oxidative DNA lesions (comet assay), substantial inhibition of lipid peroxidation (TBARS) and restoration of superoxide dismutase and S-glutathione transferase activities...
October 18, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27717661/protective-effect-of-quercetin-on-homocysteine-induced-oxidative-stress
#6
Naime Çelik, Ayhan Vurmaz, Ahmet Kahraman
OBJECTIVE: The aim of this study was to evaluate whether quercetin (QUER) treatment could have a protective effect against oxidative stress induced by homocysteinemia in rats. MATERIALS AND METHODS: Thirty-two male Sprague-Dawley rats (adult) were assigned randomly to four groups: the control group was given physiological saline (PS; 1.5 mL/d); the QUER group was given QUER (50 mg/kg body weight [BW] daily) in distilled water and 0.25 mL PS; the homocysteine (HCY) group was given HCY (1 mg/kg BW daily) in distilled water and 1...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27695265/in-vitro-antioxidant-activities-and-polyphenol-contents-of-seven-commercially-available-fruits
#7
Paramita Basu, Camelia Maier
BACKGROUND: Fruits are considered one of the richest sources of natural antioxidants. Their consumption has been linked to the prevention of oxidative stress-induced diseases. OBJECTIVE: In this study, in vitro antioxidant activities of blueberry, jackfruit, blackberry, black raspberry, red raspberry, strawberry, and California table grape extracts were evaluated. MATERIALS AND METHODS: Antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant potential (FRAP), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), nitric oxide (NO), superoxide anion (O2(-)) scavenging assays, and ferric reducing power...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27688827/antioxidant-and-vasodilator-activity-of-ugni-molinae-turcz-murtilla-and-its-modulatory-mechanism-in-hypotensive-response
#8
Ignacio Jofré, Cesar Pezoa, Magdalena Cuevas, Erick Scheuermann, Irlan Almeida Freires, Pedro Luiz Rosalen, Severino Matias de Alencar, Fernando Romero
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response. Murtilla fruits were cultivated in a germplasm bank and submitted to chemical and biological analyses. The phenolic compounds gallic acid, Catechin, Quercetin-3-β-D-glucoside, Myricetin, Quercetin, and Kaempferol were identified...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27680742/protective-effect-of-3-o-methyl-quercetin-and-kaempferol-from-semecarpus-anacardium-against-h2o2-induced-cytotoxicity-in-lung-and-liver-cells
#9
A D Naveen Kumar, Ganesh Babu Bevara, Laxmi Koteswaramma Kaja, Anil Kumar Badana, Rama Rao Malla
BACKGROUND: Hydrogen peroxide is continuously generated in living cells through metabolic pathways and serves as a source of reactive oxygen species. Beyond the threshold level, it damages cells and causes several human disorders, including cancer. METHODS: Effect of isolated 3-O-methyl quercetin and kaempferol on H2O2 induced cytotoxicity, ROS formation, plasma membrane damage, loss of mitochondrial membrane potential, DNA damage was evaluated in normal liver and lung cells...
September 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27658546/flavonoid-compounds-from-the-red-marine-alga-alsidium-corallinum-protect-against-potassium-bromate-induced-nephrotoxicity-in-adult-mice
#10
Hajer Ben Saad, Manel Gargouri, Fatma Kallel, Rim Chaabene, Tahia Boudawara, Kamel Jamoussi, Christian Magné, Khaled Mounir Zeghal, Ahmed Hakim, Ibtissem Ben Amara
Potassium bromate (KBrO3 ), an environmental pollutant, is a well-known human carcinogen and a potent nephrotoxic agent. Currently, natural products have built a well-recognized role in the management of many diseases induced by pollutants. As potent natural sources of bioactive compounds, marine algae have been demonstrated to be rich in novel secondary metabolites with a broad range of biological functions. In this study, adults male mice were orally treated for 15 days with KBrO3 (0.5 g/L) associated or not with extract of Alsidium corallinum, a red Mediterranean alga...
September 23, 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/27648146/quercetin-induces-mitochondrial-biogenesis-in-experimental-traumatic-brain-injury-via-the-pgc-1%C3%AE-signaling-pathway
#11
Xiang Li, Handong Wang, Yongyue Gao, Liwen Li, Chao Tang, Guodao Wen, Youqing Yang, Zong Zhuang, Mengliang Zhou, Lei Mao, Youwu Fan
Quercetin, a dietary flavonoid used as a food supplement, has been found to have protective effect against mitochondria damage after traumatic brain injury (TBI) in mice. However, the mechanisms underlying these effects are still not well understood. The aim of the present study was to investigate the effect of quercetin on the potential mechanism mediating these effects in the weight-drop model of TBI in male mice that were treated with quercetin or vehicle via intraperitoneal injection administration 30 min after TBI...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27628241/chemomodulatory-effect-melastoma-malabathricum-linn-against-chemically-induced-renal-carcinogenesis-rats-via-attenuation-of-inflammation-oxidative-stress-and-early-markers-of-tumor-expansion
#12
Amita Verma, Prakash Chandra Bhatt, Gaurav Kaithwas, Nikunj Sethi, Mohd Rashid, Yashwant Singh, Mahfoozur Rahman, Fahad Al-Abbasi, Firoz Anwar, Vikas Kumar
Melastoma malabathricum Linn (MM) has high valued for its commercial significance. Indian market (northeast) has great demand for the plants, which extended, its use as a traditional home remedy due to its anti-inflammatory effects. In this study, we scrutinize the therapeutic and protective effect of MM against diethylnitrosamine (DEN) and ferric nitrilotriacetate (Fe-NTA)-induced renal carcinogenesis, renal hyperproliferation, and oxidative stress in rats. Liquid chromatography mass spectroscopy (LC-MS) was used for identification of phytoconstituents...
October 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27589790/molecular-targets-underlying-the-anticancer-effects-of-quercetin-an-update
#13
REVIEW
Fazlullah Khan, Kamal Niaz, Faheem Maqbool, Fatima Ismail Hassan, Mohammad Abdollahi, Kalyan C Nagulapalli Venkata, Seyed Mohammad Nabavi, Anupam Bishayee
Quercetin, a medicinally important member of the flavonoid family, is one of the most prominent dietary antioxidants. It is present in a variety of foods-including fruits, vegetables, tea, wine, as well as other dietary supplements-and is responsible for various health benefits. Numerous pharmacological effects of quercetin include protection against diseases, such as osteoporosis, certain forms of malignant tumors, and pulmonary and cardiovascular disorders. Quercetin has the special ability of scavenging highly reactive species, such as hydrogen peroxide, superoxide anion, and hydroxyl radicals...
2016: Nutrients
https://www.readbyqxmd.com/read/27564372/metabolic-profile-and-hepatoprotective-activity-of-the-anthocyanin-rich-extract-of-hibiscus-sabdariffa-calyces
#14
Shahira M Ezzat, Maha M Salama, Sayed H Seif El-Din, Samira Saleh, Naglaa M El-Lakkany, Olfat A Hammam, Maha B Salem, Sanaa S Botros
CONTEXT: Hibiscus sabdariffa L. (Malvaceae) is a common traditional tea that has many biological activities. OBJECTIVES: To evaluate the hepatoprotective effect and study the metabolic profile of the anthocyanin-rich extract of H. sabdariffa calyces (HSARE). MATERIALS AND METHODS: The hepatoprotective activity of HSARE was assessed (100 mg/kg/d for 4 weeks) by examining the hepatic, inflammatory, oxidative stress markers and performing a histopathological examination in rats with thioacetamide (TAA)-induced hepatotoxicity...
August 26, 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27530832/augmenting-the-potency-of-third-line-antibiotics-with-berberis-aristata-in-vitro-synergistic-activity-against-carbapenem-resistant-escherichia-coli
#15
Pallavi Thakur, Raman Chawla, Rajeev Goel, Alka Narula, Rajesh Arora, Rakesh Kumar Sharma
The aim of this study was to analyse the in vitro synergistic antibacterial potential of an aquoethanolic extract of the stem bark of Berberis aristata (PTRC-2111-A) with third-line antibiotics against carbapenem-resistant Escherichia coli. PTRC-2111-A was prepared and was characterised using phytochemical- and bioactivity-based fingerprinting. Fourier transform infrared spectroscopy (FTIR) and liquid chromatography-mass spectrometry (LC-MS) analyses were performed, and superoxide and hydroxyl scavenging activities were assessed in conjunction with in vitro antimicrobial efficacy testing against the test micro-organism...
September 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27517880/evaluation-of-antioxidant-anti-cholinesterase-and-antidiabetic-potential-of-dry-leaves-and-stems-in-tamarix-aphylla-growing-wild-in-tunisia
#16
Adel Mahfoudhi, Clara Grosso, Rui F Gonçalves, Eltaief Khelifi, Saoussen Hammami, Sami Achour, Malika Trabelsi Ayadi, Patrícia Valentão, Paula B Andrade, Zine Mighri
Tamarix aphylla (L.) Karst. has a wide geographic distribution and was employed in traditional medicine as astringent, anti-rheumatic and to treat fever. T. aphylla leaves and stems extracts were studied from both chemical and biological points of view to assess the antidiabetic, anti-cholinesterase and antioxidant potential of this species. The HPLC/DAD analysis showed the presence of 14 phenolic compounds (gallic, caffeic, p-coumaric, ferulic and ellagic acids, kaempferol, quercetin, quercetin-3-O-galactoside and six flavonol derivatives)...
August 12, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27500876/-an-experimental-in-vitro-study-of-antioxidant-and-antiradical-properties-of-cytoflavin-vinpocetine-actovegin-and-ethylmethylhydroxypyridine-succinate
#17
S A Trofimova, E E Dubinina, O A Balunov, N V Leonova
AIM: To investigate experimentally in vitro the antioxidant and anti-radical activity of several drugs. MATERIAL AND METHODS: Antioxidant activity was assessed by induced luminol-dependent chemiluminescence (CL). An impact on the generation of reactive oxygen species (O2-, OH, 1D, H2O2, HClO) and their ability to inhibit the auto-oxidation of quercetin combined with the generation of superoxide radical anion were determined. Anti-radical activity was studied by the method of restoring a stable radical α-α-diphenyl-β-picryl hydrazine (DPPH) molecule of the alleged anti-oxidant...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27433287/constituents-of-french-marigold-tagetes-patula-l-flowers-protect-jurkat-t-cells-against-oxidative-stress
#18
Irakli Chkhikvishvili, Tamar Sanikidze, Nunu Gogia, Maia Enukidze, Marine Machavariani, Nana Kipiani, Yakov Vinokur, Victor Rodov
The flowers of French marigold (Tagetes patula L.) are widely used in folk medicine, in particular for treating inflammation-related disorders. However, cellular mechanisms of this activity demand further investigation. In the present work, we studied the potential of T. patula compounds to alleviate the oxidative stress in hydrogen peroxide-challenged human lymphoblastoid Jurkat T-cells. Crude extracts of marigold flowers and purified fractions containing flavonoids patuletin, quercetagetin, and quercetin and their derivatives, as well as the carotenoid lutein, were brought in contact with Jurkat cells challenged with 25 or 50 μM H2O2...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27385396/altered-redox-mitochondrial-biology-in-the-neurodegenerative-disorder-fragile-x-tremor-ataxia-syndrome-use-of-antioxidants-in-precision-medicine
#19
Gyu Song, Eleonora Napoli, Sarah Wong, Randi Hagerman, Siming Liu, Flora Tassone, Cecilia Giulivi
A 55-200 expansion of the CGG nucleotide repeat in the 5'-UTR of the fragile X mental retardation 1 gene (FMR1) is the hallmark of the triplet nucleotide disease known as the "premutation" as opposed to those with >200 repeats, known as the full mutation or fragile X syndrome. Originally, premutation carriers were thought to be free of phenotypic traits; however, some are diagnosed with emotional and neurocognitive issues and, later in life, with the neurodegenerative disease fragile X-associated tremor/ataxia syndrome (FXTAS)...
June 30, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/27381473/vitis-vinifera-l-cv-pinot-noir-pomace-and-lees-as-potential-sources-of-bioactive-compounds
#20
Gabriel M Reis, Henrique Faccin, Carine Viana, Marcelo Barcellos da Rosa, Leandro M de Carvalho
Food and agricultural industries generate substantial quantities of phenolic-rich by-products that could be valuable natural sources of antioxidants. The aim of this study was to identify and quantify the phenolic compounds and radical scavenging activities of two by-products (pomace and lees) from Vitis vinifera L. cv Pinot noir. We found a different distribution of phenolic classes (flavanols, flavonols, phenolic acids and stilbenes) and singular scavenging activity against free radicals (hydroxyl, superoxide and peroxyl radicals)...
November 2016: International Journal of Food Sciences and Nutrition
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