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Superoxide AND pain

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https://www.readbyqxmd.com/read/27901334/differential-efficacy-of-methylcobalamin-and-alpha-lipoic-acid-treatment-on-negative-and-positive-symptoms-of-type-2-diabetic-peripheral-neuropathy
#1
Yajuan Han, Min Wang, Jie Shen, Zhen Zhang, Min Zhao, Jing Huang, Youming Chen, Zhi Chen, Yulan Hu, Yubing Wang
BACKGROUND: Diabetic hyperglycemia damages peripheral nerves by triggering ischemia, oxidative stress, and inflammation. Alpha-lipoic acid (ALA) and methylcobalamin (MC) are known to improve signs of diabetic peripheral neuropathy (DPN), possibly by enhancing neural and vascular endothelial cell metabolism and antioxidant capacity. We evaluated differences in efficacy following short-term MC or ALA treatment on DPN symptoms to guide clinical drug selection. METHODS: Forty DPN patients were randomly divided into MC and ALA treatment groups (n=20/20) and assessed by the Toronto Clinical Neuropathy Scoring System (TCSS), total symptom score (TSS), visual analog scale (VAS) of positive symptoms, and easy sensory test (EST) for negative symptoms before and after 2 weeks of treatment...
November 30, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27842920/nitroxidative-signaling-mechanisms-in-pathological-pain
#2
REVIEW
Peter M Grace, Andrew D Gaudet, Vasiliki Staikopoulos, Steven F Maier, Mark R Hutchinson, Daniela Salvemini, Linda R Watkins
Tissue injury can initiate bidirectional signaling between neurons, glia, and immune cells that creates and amplifies pain. While the ability for neurotransmitters, neuropeptides, and cytokines to initiate and maintain pain has been extensively studied, recent work has identified a key role for reactive oxygen and nitrogen species (ROS/RNS; nitroxidative species), including superoxide, peroxynitrite, and hydrogen peroxide. In this review we describe how nitroxidative species are generated after tissue injury and the mechanisms by which they enhance neuroexcitability in pain pathways...
November 11, 2016: Trends in Neurosciences
https://www.readbyqxmd.com/read/27817235/-psoriasis-and-oxidative-stress
#3
Iván Péter, Anna Jagicza, Zénó Ajtay, István Kiss, Balázs Németh
Psoriasis is among the most common dermatological diseases worldwide. Its significance is emphasized by adverse effects on quality of life, caused by chronic pain, physical and psychical disability due to psoriatic plaques. Besides the development of psoriatic arthritis, which often causes permanent joint damage, former studies revealed an increased risk of inflammatory bowel disease, cardiovascular disease and certain types of cancer. Genetic predisposition and oxidative stress caused by exogenous and endogenous factors can contribute to abnormal differentiation and hyperproliferation of keratinocytes, accordingly the development and maintenance of psoriasis...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27776508/protective-effects-of-fraxinus-xanthoxyloides-wall-leaves-against-ccl4-induced-hepatic-toxicity-in-rat
#4
Tahira Younis, Muhammad Rashid Khan, Moniba Sajid
BACKGROUND: Leaves and root bark of Fraxinus xanthoxyloides Wall. (Oleaceae) are used locally for the treatment of jaundice, malaria and pneumonia. Decoction of stem, twigs and bark is used in pain, internal injuries, rheumatism and in bone fracture. In this investigation we have evaluated the methanol extract of leaves for its hepatoprotective potential against CCl4 induced hepatic injuries in rat. METHODS: Powder of F. xanthoxyloides leaves was extracted with methanol (FXM) and subjected for the determination of polyphenolics through HPLC-DAD analysis...
October 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27733068/elucidating-the-role-of-oxidative-stress-in-the-therapeutic-effect-of-rutin-on-experimental-acute-pancreatitis
#5
Fabíula Francisca Abreu, Ana Carla Araujó de Souza, Simone Aparecida Teixeira, Antônio Garcia Soares, Daiane Franco Teixeira, Rosilene Calazans Soares, Marilia Trindade Santana, Sandra Lauton Santos, Soraia Kátia Pereira Costa, Marcelo Nicolas Muscará, Enilton Aparecido Camargo
INTRODUCTION: Acute pancreatitis (AP) may be severe and cause hospitalization or death, and the available treatment is insufficient to control pancreatic inflammation and pain. Rutin is a natural flavonoid with the potential to treat AP via anti-inflammatory, antinociceptive and antioxidant activities. AIM: This study investigated the beneficial effects of rutin on experimental AP induced by L-arginine administration in mice. METHODS: The L-arginine-induced AP model was used in Swiss mice (n = 6-8)...
October 13, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27714773/histamine-h4-receptor-agonist-induced-relief-from-painful-peripheral-neuropathy-is-mediated-by-inhibition-of-spinal-neuroinflammation-and-oxidative-stress
#6
Maria Domenica Sanna, Laura Lucarini, Mariaconcetta Durante, Carla Ghelardini, Emanuela Masini, Nicoletta Galeotti
BACKGROUND AND PURPOSE: Neuropathic pain is under-treated, with a detrimental effect on quality of life, partly because of low treatment efficacy, but also because pathophysiological mechanisms are not fully elucidated. To clarify the pathobiology of neuropathic pain, we studied the contribution of neuroinflammation and oxidative stress in a model of peripheral neuropathy. We also assessed an innovative treatment for neuropathic pain by investigating the effects of histamine H4 receptor ligands in this model...
October 7, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27701898/differential-regulation-of-oxidative-stress-and-cytokine-production-by-endothelin-eta-and-etb-receptors-in-superoxide-anion-induced-inflammation-and-pain-in-mice
#7
Victor Fattori, Karla G G Serafim, Ana C Zarpelon, Sergio M Borghi, Felipe A Pinho-Ribeiro, José C Alves-Filho, Thiago M Cunha, Fernando Q Cunha, Rúbia Casagrande, Waldiceu A Verri
The present study investigated whether endothelin-1 acts via ETA or ETB receptors to mediate superoxide anion-induced pain and inflammation. Mice were treated with clazosentan (ETA receptor antagonist) or BQ-788 (ETB receptor antagonist) prior to stimulation with the superoxide anion donor, KO2. Intraplantar treatment with 30 nmol of clazosentan or BQ-788 reduced mechanical hyperalgesia (47% and 42%), thermal hyperalgesia (68% and 76%), oedema (50% and 30%); myeloperoxidase activity (64% and 32%), and overt-pain like behaviours, such as paw flinching (42% and 42%) and paw licking (38% and 62%), respectively...
October 5, 2016: Journal of Drug Targeting
https://www.readbyqxmd.com/read/27693316/selective-scavenging-of-intra-mitochondrial-superoxide-corrects-diclofenac-induced-mitochondrial-dysfunction-and-gastric-injury-a-novel-gastroprotective-mechanism-independent-of-gastric-acid-suppression
#8
Somnath Mazumder, Rudranil De, Souvik Sarkar, Asim Azhar Siddiqui, Shubhra Jyoti Saha, Chinmoy Banerjee, Mohd Shameel Iqbal, Shiladitya Nag, Subhashis Debsharma, Uday Bandyopadhyay
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat multiple inflammatory diseases and pain but severe gastric mucosal damage is the worst outcome of NSAID-therapy. Here we report that mitoTEMPO, a mitochondrially targeted superoxide (O2(-)) scavenger protected as well as healed gastric injury induced by diclofenac (DCF), the most commonly used NSAID. Common existing therapy against gastric injury involves suppression of gastric acid secretion by proton pump inhibitors and histamine H2 receptor antagonists; however, dyspepsia, vitamin B12 deficiency and gastric microfloral dysbalance are the major drawbacks of acid suppression...
September 28, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27681718/effects-of-sanguis-draconis-on-perforator-flap-survival-in-rats
#9
Yang Zhang, Xiaobing Cai, Lifeng Shen, Xiaowen Huang, Xuping Wang, Yinan Lan, Dan Shou
Sanguis draconis, a resin known to improve blood circulation, relieve pain, stimulate tissue regeneration, and heal wounds, is widely used in clinical practice. In this study, we prepared an ethanol extract of sanguis draconis (EESD) containing 75.08 mg/g of dracorhodin. The experiment was carried out on 20 rats that were divided into two groups, a control group (n = 10) and an EESD group (n = 10). All the rats underwent a perforator flap surgery, after which post-operative abdominal compressions of EESD were given to the EESD group for seven days, while the control group received saline...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27609150/anti-inflammatory-analgesic-and-antioxidant-activities-of-3-4-oxo-isopropylidene-shikimic-acid
#10
Jin-Yao Sun, Cui-Yu You, Kai Dong, Hai-Sheng You, Jian-Feng Xing
Context 3,4-Oxo-isopropylidene-shikimic acid (ISA) is an analog of shikimic acid (SA). SA is extracted from the dry fruit of Illicium verum Hook. f. (Magnoliaceae), which has been used for treating stomachaches, skin inflammation and rheumatic pain. Objective To investigate the anti-inflammatory, analgesic and antioxidant activities of ISA. Materials and methods Analgesic and anti-inflammatory activities of ISA were evaluated using writhing, hot plate, xylene-induced ear oedema, carrageenan-induced paw oedema and cotton pellets-induced granuloma test, meanwhile the prostaglandin E2 (PGE2) and malondialdehyde (MDA) levels were assessed in the oedema paw tissue...
October 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27603689/glorisa-superba-hydroalcoholic-extract-from-tubers-attenuates-experimental-arthritis-by-downregulating-inflammatory-mediators-and-phosphorylation-of-erk-jnk-p-38
#11
Rohit Kumar, Yogendra Kumar Gupta, Surender Singh, Amol Patil
Glorisa superba (GS) is a medicinal plant that has been traditionally used in the treatment of joint pain and rheumatoid arthritis (RA). The present study was carried out to investigate the antiarthritic activity of Glorisa superba hydroalcoholic extract (GSHE) in an adjuvant-induced arthritis (AIA) rat model. Arthritis was induced by sub-plantar administration of complete Freund's adjuvant (CFA) and GSHE (25, 50, or 100 mg/kg/day) was administered orally for 21 consecutive days. Joint diameter was measured on Days 0, 3, 7, 14, and 21...
October 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27601184/neuronal-nos-activates-spinal-nadph-oxidase-2-contributing-to-central-sigma-1-receptor-induced-pain-hypersensitivity-in-mice
#12
Sheu-Ran Choi, Soon-Gu Kwon, Hoon-Seong Choi, Ho-Jae Han, Alvin James Beitz, Jang-Hern Lee
We recently demonstrated that activation of spinal sigma-1 receptors (Sig-1Rs) induces pain hypersensitivity via the activation of neuronal nitric oxide synthase (nNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (Nox2). However, the potential direct interaction between nNOS-derived nitric oxide (NO) and Nox2-derived reactive oxygen species (ROS) is poorly understood, particularly with respect to the potentiation of N-methyl-D-aspartate (NMDA) receptor activity in the spinal cord associated with the development of central sensitization...
December 1, 2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27565759/chronic-prostatitis-chronic-pelvic-pain-syndrome-impairs-erectile-function-through-increased-endothelial-dysfunction-oxidative-stress-apoptosis-and-corporal-fibrosis-in-a-rat-model
#13
Y Hu, X Niu, G Wang, J Huang, M Liu, B Peng
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is an independent risk factor for the development of erectile dysfunction (ED). But the molecular mechanisms underlying the relationship between CP/CPPS and ED are still unclear. The aim of this study was to investigate the effect of CP/CPPS on erectile function in a rat model and the possible mechanisms. A rat model of experimental autoimmune prostatitis (EAP) was established to mimic human CP⁄CPPS. Then twenty 2-month-old male Sprague-Dawley rats were divided into EAP group and control group...
August 27, 2016: Andrology
https://www.readbyqxmd.com/read/27561290/neuroprotective-effect-of-matrine-in-mouse-model-of-vincristine-induced-neuropathic-pain
#14
Shuai-Shuai Gong, Yu-Xiang Li, Meng-Ting Zhang, Juan Du, Peng-Sheng Ma, Wan-Xia Yao, Ru Zhou, Yang Niu, Tao Sun, Jian-Qiang Yu
Chemotherapy drugs such as vincristine (VCR) can cause neuropathic pain, and there is still lack of ideal strategy to treat it. The current study was designed to investigate effect of matrine (MT) on VCR-induced neuropathic pain in animal model. VCR (75 μg/kg, i.p. for 10 consecutive days) was administered to induce painful neuropathy model in mice. MT (15, 30 and 60 mg/kg, i.p.) and pregabalin (10 mg/kg, i.p.) were administered for 11 consecutive days. Various tests were performed to assess the degree of pain at different days (1, 6, 11, 16, and 21)...
August 25, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27504866/potential-contribution-of-antioxidant-mechanism-in-the-defensive-effect-of-lycopene-against-partial-sciatic-nerve-ligation-induced-behavioral-biochemical-and-histopathological-modification-in-wistar-rats
#15
R Goel, N Tyagi
Neuropathic pain is a severe and unbearable condition which arises due to activation of peripheral nociceptors after tissue damage, neuropathic pain is caused from anomalous physiology of central or peripheral nervous system and it may not be related to the ongoing tissue damage or inflammation. Involvement of oxidative damage has been reported in the pathophysiology of neuropathic pain. The purpose of this study was to examine the effect of lycopene to quench the free radicals produced as a result of the increased oxidative stress in neuropathic pain...
December 2016: Drug Research
https://www.readbyqxmd.com/read/27470363/molecular-and-histological-changes-in-cerebral-cortex-and-lung-tissues-under-the-effect-of-tramadol-treatment
#16
Eatemad A Awadalla, Alaa-Eldin Salah-Eldin
Tramadol abuse is one of the most frequent health problems in Egypt and worldwide. In most cases, tramadol abused by men face a problem with premature ejaculation. Tramadol like other opioids induces a decrease in plasma antioxidant levels, which may reflect a failure of the antioxidant defense mechanism against oxidative damage. The present work aimed to study the possible deleterious effects of oral administration of tramadol on brain and lung tissues in rats. Twenty adult male albino rats were divided into two groups; a control administered with normal saline and tramadol-treated (40mg/kg b...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27449823/natural-flavonoids-as-promising-analgesic-candidates-a-systematic-review
#17
REVIEW
Xiao Xiao, Xiaoyu Wang, Xuan Gui, Lu Chen, Baokang Huang
Due to the chemical structural diversity and various analgesic mechanisms, an increasing number of studies indicated that some flavonoids from medicinal plants could be promising candidates for new natural analgesic drugs, which attract high interests of advanced users and academic researchers. The aim of this systematic review is to report flavonoids and its derivatives as new analgesic candidates based on the pharmacological evidences. Sixty-four papers were found concerning the potential analgesic activity of 46 flavonoids...
November 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27432278/zisheng-shenqi-decoction-ameliorates-monosodium-urate-crystal-induced-gouty-arthritis-in-rats-through-anti-inflammatory-and-anti-oxidative-effects
#18
Jieru Han, Ying Xie, Fangyu Sui, Chunhong Liu, Xiaowei Du, Chenggang Liu, Xiaoling Feng, Deyou Jiang
Based on traditional Chinese medicinal theories on gouty arthritis, Zisheng Shenqi decoction (ZSD), a novel Chinese medicinal formula, was developed due to its multiple functions, including reinforcing renal function, promoting blood circulation and relieving pain. In the present study, the effect of ZSD on monosodium urate (MSU) crystal-induced gouty arthritis in rats was investigated and the underlying mechanisms were examined. The data from these investigations showed that the injection of MSU crystals into the ankle joint cavity caused significant elevations in ankle swelling and inflammatory cell infiltration into the synovium, whereas these abnormal changes were markedly suppressed by oral administration of ZSD (40 mg/kg) for 7 days...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27424012/enhancement-of-cisplatin-nephrotoxicity-by-morphine-and-its-attenuation-by-the-opioid-antagonist-naltrexone
#19
Atefeh Aminian, Shiva Javadi, Reza Rahimian, Ahmad Reza Dehpour, Fahimeh Asadi Amoli, Payman Moghaddas, Shahram Ejtemaei Mehr
Nephrotoxicity is a major side effect of cisplatin, a widely used chemotherapy agent. Morphine and other opioids are also used extensively in different types of cancer for the clinical management of pain associated with local or metastatic neoplastic lesions. In addition to its analgesic effects, morphine has also been reported to possess potential immunomodulatory and antioxidant properties. Herein, we investigated the effects of morphine in a rat model of cisplatin-induced nephrotoxicity. Following administration of a single dose of cisplatin (5 mg/kg), animals received intraperitoneal injections of morphine (5 mg/kg/day) and/or naltrexone (20 mg/kg/day), an opioid antagonist, for 5 days...
July 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27364639/distribution-of-mefv-gene-mutations-and-r202q-polymorphism-in-the-serbian-population-and-their-influence-on-oxidative-stress-and-clinical-manifestations-of-inflammation
#20
Jelena Milenković, Jelena Vojinović, Maruša Debeljak, Nataša Toplak, Dragana Lazarević, Tadej Avčin, Tatjana Jevtović-Stoimenov, Dušica Pavlović, Vladmila Bojanić, Maja Milojković, Gordana Kocić, Andrej Veljković
BACKGROUND: The Mediterranean fever (MEFV) gene codes for protein pyrin, one of the regulators of inflammasome activity in innate immune cells. Mutations in this gene are considered the primary cause of Familial Mediterranean fever, but are also found in other monogenic and multifactorial autoinflammatory diseases. The aim of the study was to determine if healthy carriers of MEFV gene mutations and R202Q polymorphism have clinical manifestations of inflammation and impaired oxidative stress parameters...
2016: Pediatric Rheumatology Online Journal
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