keyword
MENU ▼
Read by QxMD icon Read
search

Superoxide anion

keyword
https://www.readbyqxmd.com/read/28350760/involvement-of-hsp70-and-ho-1-in-the-protective-effects-of-raloxifene-on-multiple-organ-dysfunction-syndrome-by-endotoxemia-in-ovariectomized-rats
#1
Hsin-Hsueh Shen, Shieh-Yang Huang, Pao-Yun Cheng, Yen-Ju Chu, Shu-Ying Chen, Kwok-Keung Lam, Yen-Mei Lee
OBJECTIVE: Accumulating evidence demonstrates that raloxifene, a selective estrogen receptor modulator, possesses anti-inflammatory action. This study evaluates the preventive effects of long-term treatment of raloxifene on acute inflammation and multiple organ dysfunction syndrome (MODS) in ovariectomized (OVX) rats with endotoxemia and its underlying mechanism of action. METHODS: Adult female rats were OVX bilaterally to induce estrogen insufficiency. OVX rats were administered with raloxifene (1 mg/kg, gavage, once daily) for 8 weeks, beginning 1 week after surgery, followed by induction of sepsis via intravenous infusion of lipopolysaccharides (LPS; 30 mg/kg) for 4 hours...
March 27, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28344090/isolation-characterization-and-bioactivities-of-the-polysaccharides-from-dicliptera-chinensis-l-juss
#2
Yourui Xu, Ya Gao, Mingli Zhong, Jun Li, Houkang Cao, Simao Huang, Riming Wei, Kefeng Zhang
The polysaccharides of Dicliptera chinensis(L.) Juss. (DCP-1 and DCP-2) were extracted and isolated using the methods of water extract-ethanol precipitate and sephadex column chromatography and characterized by gel permeation chromatography (GPC), fourier transform infrared spectrometry (FT-IR) and gas chromatography (GC), respectively. The antioxidant activity of DCPs was evaluated by scavenging activity of DPPH, hydroxyl, superoxide anion and ABTS radical. Moreover, the anti-aging activity of DCP-2 was investigated using an aging model-induced by D-galactose (D-gal) in mice...
March 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28344087/subacute-alcohol-and-or-disulfiram-intake-affects-bioelements-and-redox-status-in-rat-testes
#3
Ana Djuric, Aida Begic, Borko Gobeljic, Ana Pantelic, Goran Zebic, Ivana Stevanovic, Dragan Djurdjevic, Milica Ninkovic, Vera Prokic, Ivan Stanojevic, Danilo Vojvodic, Mirjana Djukic
The aim of the study was to investigate if alcohol and disulfiram (DSF) individually and in combination affect bioelements' and red-ox homeostasis in testes of the exposed rats. The animals were divided into groups according to the duration of treatment (21 and/or 42 days): C21/C42 groups (controls); OL21/OL42 groups (0.5 mL olive oil intake); A1-21 groups (3 mL 20% ethanol intake); DSF1-21 groups (178.5 mg DSF/kg/day); and A21+DSF22-42 groups (the DSF ingestion followed previous 21 days' treatment with alcohol)...
March 23, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28342430/exposure-to-a-magnetic-field-or-laser-radiation-ameliorates-effects-of-pb-and-cd-on-physiology-and-growth-of-young-wheat-seedlings
#4
Yi-Ping Chen, Dong Chen, Qiang Liu
Lead (Pb) and cadmium (Cd) contamination of soils pose significant problems for successful seed germination and establishment. We compared effects of subjecting wheat seeds either to a magnetic field (MF: 0-800 millitesla) or laser radiation (LR: 0-8min at 20mW/mm(2)) on wheat seed germination and on physiology and growth of young seedlings exposed to these two heavy metals as seeds and as 2-day-old seedlings. Intermediate levels of either MF or LR increased germination. In seeds untreated by MF or LR, exposure to Cd and Pb resulted in: significant increases in the concentrations of malondialdehyde ([MDA]) and superoxide anion radical ([O2(-)]), and in the conductivity of electrolyte leakage (CEL); significant decreases in catalase (CAT), superoxide dismutase (SOD), and glutathione reductase (GR) activity; a significant decrease in glutathione concentration ([GSH]); and a significant decrease in shoot biomass relative to seeds exposed to these heavy metals following MF or LR treatments...
March 18, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28341178/mechanisms-underlying-sodium-nitroprusside-induced-tolerance-in-the-mouse-aorta-role-of-ros-and-cyclooxygenase-derived-prostanoids
#5
Mariana C Diniz, Vania C Olivon, Lívia D Tavares, Janaina A Simplicio, Natália A Gonzaga, Daniele G de Souza, Lusiane M Bendhack, Carlos R Tirapelli, Daniella Bonaventura
AIMS: To determine the role of reactive oxygen species (ROS) on sodium nitroprusside (SNP)-induced tolerance. Additionally, we evaluated the role of ROS on NF-κB activation and pro-inflammatory cytokines production during SNP-induced tolerance. MAIN METHODS: To induce in vitro tolerance, endothelium-intact or -denuded aortic rings isolated from male Balb-c mice were incubated for 15, 30, 45 or 60min with SNP (10nmol/L). KEY FINDINGS: Tolerance to SNP was observed after incubation of endothelium-denuded, but not endothelium-intact aortas for 60min with this inorganic nitrate...
March 21, 2017: Life Sciences
https://www.readbyqxmd.com/read/28340693/protective-effects-of-bezafibrate-against-elaidic-acid-induced-accumulation-of-lipid-droplets-in-monocytic-cells
#6
S Haj Ahmed, W Kharroubi, A Zarrouk, F Brahmi, T Nury, G Lizard, M Hammami
Some factors related to diet, such as trans fatty acids (TFA), are known to be involved in the progression of atherosclerosis in humans. Thus, the aim of our study was (i) to evaluate the effects of three dietary free fatty acids (FFA) (elaidic (EA), oleic (OA) and palmitic acid (PA)) on U937 human monocytes, and (ii) to study the eventual benefits of bezafibrate (BZF), a pan-agonist for PPAR isoforms (α, γ and δ) in U937 cells treated with FFA. Morphologic and functional changes were investigated by microscopic and flow cytometric methods...
January 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28339179/synthesis-of-111-facet-exposed-mgo-with-surface-oxygen-vacancies-for-ros-generation-in-the-dark
#7
Ying-Juan Hao, Bing Liu, Li-Gang Tian, Fa-Tang Li, Jie Ren, Shao-Jia Liu, Ying Liu, Jun Zhao, Xiaojing Wang
Seeking a simple and moderate route to generate reactive oxygen species (ROS) for antibiosis is of great interest and challenge. This work demonstrates that molecule transition and electron rearrangement processes can directly occur only through chemisorption interaction between the adsorbed O2 and high-energy {111} facet-exposed MgO with abundant surface oxygen vacancies (SOVs), hence producing singlet oxygen and superoxide anion radicals without light irradiation. These ROS were confirmed by electron paramagnetic resonance, in-situ Raman and scavenger experiments, respectively...
March 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28338370/the-potential-of-stimulating-nitric-oxide-formation-in-the-treatment-of-hypertension
#8
Lucas C Pinheiro, Jose E Tanus-Santos, Michele M Castro
Hypertension is a leading cause of morbidity and mortality worldwide. A major pathophysiological factor contributing to hypertension is reduced nitric oxide (NO) bioavailability. Strategies to address this pathophysiological mechanism could offer significant advantages. Areas covered: In this review we aimed at examining a variety of drugs (statins, beta-adrenergic receptor blockers, calcium channel blockers, angiotensin converting enzyme inhibitors, angiotensin II type-1 receptor blockers) used to treat hypertension and other cardiovascular diseases, particularly with respect to their potential of increasing NO bioavailability and activity in the cardiovascular system...
March 24, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28338089/neurotoxicity-comparison-of-two-types-of-local-anaesthetics-amide-bupivacaine-versus-ester-procaine
#9
Xu-Jiao Yu, Wei Zhao, Yu-Jie Li, Feng-Xian Li, Zhong-Jie Liu, Hua-Li Xu, Lu-Ying Lai, Rui Xu, Shi-Yuan Xu
Local anaesthetics (LAs) may lead to neurological complications, but the underlying mechanism is still unclear. Many neurotoxicity research studies have examined different LAs, but none have comprehensively explored the distinct mechanisms of neurotoxicity caused by amide- (bupivacaine) and ester- (procaine) type LAs. Here, based on a CCK8 assay, LDH assay, Rhod-2-AM and JC-1 staining, 2',7'-dichlorohy-drofluorescein diacetate and dihydroethidium probes, an alkaline comet assay, and apoptosis assay, we show that both bupivacaine and procaine significantly induce mitochondrial calcium overload and a decline in the mitochondrial membrane potential as well as overproduction of ROS, DNA damage and apoptosis (P < 0...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28336968/new-cofactors-and-inhibitors-for-a-dna-cleaving-dnazyme-superoxide-anion-and-hydrogen-peroxide-mediated-an-oxidative-cleavage-process
#10
Yanhong Sun, Rulong Ma, Shijin Wang, Guiying Li, Yongjie Sheng, Hongyue Rui, Jin Zhang, Jiacui Xu, Dazhi Jiang
Herein, we investigated the effects of new cofactors and inhibitors on an oxidative cleavage of DNA catalysis, known as a pistol-like DNAzyme (PLDz), to discuss its catalytic mechanism. PLDz performed its catalytic activity in the presence of ascorbic acid (AA), in which Cu(2+) promoted, whereas Fe(2+) significantly inhibited the catalytic function. Since Fe(2+)/AA-generated hydroxyl radicals are efficient on DNA damage, implying that oxidative cleavage of PLDz had no relation with hydroxyl radical. Subsequently, we used Fe(2+)/H2O2 and Cu(2+)/H2O2 to identify the role of hydroxyl radicals in PLDz catalysis...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28336528/platelet-cd36-promotes-thrombosis-by-activating-redox-sensor-erk5-in-hyperlipidemic-conditions
#11
Moua Yang, Brian C Cooley, Wei Li, Yiliang Chen, Jeannette Vasquez-Vivar, Na'il O Scoggins, Scott J Cameron, Craig N Morrell, Roy L Silverstein
Atherothrombosis is a process mediated by dysregulated platelet activation that can cause life-threatening complications and is the leading cause of death by cardiovascular disease. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in LDL particles, a process which induces an overt prothrombotic phenotype. The mechanisms by which CD36 promotes platelet activation and thrombosis remain incompletely defined. In this study, we identify a mechanism for CD36 to promote thrombosis by increasing activation of MAP kinase ERK5, a protein kinase known to be exquisitely sensitive to redox stress, through a signaling pathway requiring Src kinases, NADPH oxidase, superoxide radical anion and hydrogen peroxide...
March 23, 2017: Blood
https://www.readbyqxmd.com/read/28336198/augmented-oxidative-stress-in-infertile-women-with-persistent-chlamydial-infection
#12
Jelena Tošić-Pajić, Dragana Šeklić, Jelena Radenković, Snežana Marković, Jelena Čukić, Dejan Baskić, Suzana Popović, Milos Todorovic, Predrag Sazdanović
There is established association between oxidative stress, infections of genital tract and fertility. Genital tract infections may provoke increased production of free radicals and generate oxidative stress that can be involved in pathophysiology of a number of reproductive diseases and complications during pregnancy. The aim of this study was to determine connection between oxidative stress and infertility associated with persistent chlamydial infection. Serum samples of infertile women with tubal factor infertility (TFI), women with multiple spontaneous abortions (MSA) and fertile women was screened for C...
March 20, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28334681/fluorescent-proteins-such-as-egfp-lead-to-catalytic-oxidative-stress-in-cells
#13
Douglas Ganini, Fabian Leinisch, Ashutosh Kumar, JinJie Jiang, Erik J Tokar, Christine C Malone, Robert M Petrovich, Ronald P Mason
Fluorescent proteins are an important tool that has become omnipresent in life sciences research. They are frequently used for localization of proteins and monitoring of cells [1,2]. Green fluorescent protein (GFP) was the first and has been the most used fluorescent protein. Enhanced GFP (eGFP) was optimized from wild-type GFP for increased fluorescence yield and improved expression in mammalian systems [3]. Many GFP-like fluorescent proteins have been discovered, optimized or created, such as the red fluorescent protein TagRFP [4]...
March 10, 2017: Redox Biology
https://www.readbyqxmd.com/read/28327717/one-step-synthesis-electronic-structure-and-photocatalytic-activity-of-earth-abundant-visible-light-driven-feal2o4
#14
Hui-Ying Mu, Fa-Tang Li, Xing-Tao An, Rui-Hong Liu, Yi-Lei Li, Xin Qian, Yong-Qi Hu
The development of inexpensive visible-light-driven photocatalysts is an important prerequisite for realizing the industrial application of photocatalysis technology. In this paper, an earth-abundant FeAl2O4 photocatalyst is prepared via facile solution combustion synthesis. Density functional theory and the scanning Kelvin probe technique are employed to ascertain the positions of the energy bands and the Fermi level. Phenol is taken as a model pollutant to evaluate the photocatalytic activity of FeAl2O4. The scavenger experiment results, ˙OH-trapping fluorescence technique, and electron spin resonance measurements confirm that the superoxide anion radical is the main active species generated in the photocatalytic process, which also further corroborates the proposed electronic structure of FeAl2O4...
March 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28326625/alantolactone-and-isoalantolactone-prevent-amyloid-%C3%AE-25-35-induced-toxicity-in-mouse-cortical-neurons-and-scopolamine-induced-cognitive-impairment-in-mice
#15
Ji Yeon Seo, Soon Sung Lim, Jiyoung Kim, Ki Won Lee, Jong-Sang Kim
Given the evidence for detoxifying/antioxidant enzyme-inducing activities by alantolactone (AL) and isoalantolactone (IAL), the purpose of this study was to investigate the effects of AL and IAL on Aβ25-35 -induced cell death in mouse cortical neuron cells and to determine their effects on scopolamine-induced amnesia in mice. Our data demonstrated that both compounds effectively attenuated the cytotoxicity of Aβ25-35 (10 μM) in neuronal cells derived from the mouse cerebral cortex. It was also found that the production of intracellular reactive oxygen species, including superoxide anion induced by Aβ25-35 , was inhibited...
March 21, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28326000/antioxidant-activities-of-aqueous-extracts-from-12-chinese-edible-flowers-in-vitro-and-in-vivo
#16
Feng Wang, Miao Miao, Hui Xia, Li-Gang Yang, Shao-Kang Wang, Gui-Ju Sun
The antioxidant function of edible flowers have attracted increasing interest. However, information is lacking on the impact of edible flowers on oxidative injury including hypoxia-re-oxygenation and hyperlipidemia. The antioxidant activities of aqueous extracts from 12 Chinese edible flowers were assessed in four different antioxidant models, including total antioxidant capacity (TAC), oxygen radical absorbance capacity (ORAC), scavenging hydroxyl radical capacity (SHRC) and scavenging superoxide anion radical capacity (SSARC)...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28324190/exogenous-application-of-urea-and-a-urease-inhibitor-improves-drought-stress-tolerance-in-maize-zea-mays-l
#17
Wei Gou, Pufan Zheng, Li Tian, Mei Gao, Lixin Zhang, Nudrat Aisha Akram, Muhammad Ashraf
Drought is believed to cause many metabolic changes which affect plant growth and development. However, it might be mitigated by various inorganic substances, such as nitrogen. Thus, the study was carried out to investigate the effect of foliar-applied urea with or without urease inhibitor N-(n-butyl) thiophosphoric triamide (NBPT) on a maize cultivar under drought stress simulated by 15% (w/v) polyethylene glycol 6000. Foliar-applied urea resulted in a significant increase in plant dry weight, relative water content, and photosynthetic pigments under water stress condition...
March 21, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28323499/antiproliferative-activity-of-egg-yolk-peptides-in-human-colon-cancer-cells
#18
Marwa N Yousr, Akram A Aloqbi, Ulfat M Omar, Nazlin K Howell
Egg yolk peptides were successfully prepared from egg yolk protein by-products after lecithin extraction. Defatted egg yolk protein was hydrolyzed with pepsin and pancreatin and purified by gel filtration to produce egg yolk gel filtration fraction (EYGF-33) with antiproliferative activity. The highlight of this study was that the peptide EYGF-33 (1.0 mg/ml) significantly inhibits cell viability of colon cancer cells (Caco-2) with no inhibitory effects on the viability of human colon epithelial normal cells (HCEC) after 48 h...
March 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28322144/antioxidant-and-antiproliferative-potential-of-fruiting-bodies-of-the-wild-growing-king-bolete-mushroom-boletus-edulis-agaricomycetes-from-western-serbia
#19
Aleksandra Novakovic, Maja Karaman, Sonja Kaisarevic, Tanja Radusin, Nebojsa Llic
The aim of this work was to study the bioactivity of crude aqueous and ethanolic extracts of Boletus edulis prepared from caps and stipes of wild-growing basidiocarps collected from the Prijepolje region (western Serbia). The bioactivity screening included antioxidant (2,2-diphenyl-l-picrylhydrazyl [DPPH], nitric oxide, super-oxide anion*, and hydroxyl radicals and ferric-reducing antioxidant power) and antiproliferative MTT assays (human breast MCF-7 cancer cell line). In addition, all extracts were primarily characterized by ultraviolet/visible spectrophotometry to determine total phenolic and flavonoid contents...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28322088/alpha-tocopherol-dependent-salt-tolerance-is-more-related-with-auxin-synthesis-rather-than-enhancement-antioxidant-defense-in-soybean-roots
#20
Seda Sereflioglu, Burcu Seckin Dinler, Eda Tasci
In this paper, we describe the alleviated effects of alpha-tocopherol (α-T) on oxidative damage and its possible role as a signal transmitter in plants during salt stress. The results show that exogenously applied α-T under salt stress increased root length and weight, but reduced hydrogen peroxide (H2O2), superoxide anion radical (O2(.)-) and malondialdehyde (MDA) content in soybean roots. The proline content was reduced by α-T treatment. Interestingly, endogenous auxin (IAA) level was significantly increased after α-T application as compared to salt stress alone...
March 2017: Acta Biologica Hungarica
keyword
keyword
96106
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"