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Histological subtypes oral cancer

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https://www.readbyqxmd.com/read/27746875/angiosarcoma-a-case-report-of-gingival-disease-with-both-palatine-tonsils-localization
#1
Frédéric Chamberland, Tristan Maurina, Séverine Degano-Valmary, Thierry Spicarolen, Loïc Chaigneau
Angiosarcomas are one of the rarest subtypes of sarcomas; those are malignant vascular tumors arising from vascular endothelial cells. Occurrence of intra-oral angiosarcoma is extremely rare (0.0077% of all cancers in Europe). We present here, to our knowledge, the first case of a 83-year-old man with gingival and both palatine tonsils localization of a grade-two angiosarcoma discovered after a two months history of a painful lesion followed by hematoma and spontaneous bleeding. Chemotherapy with paclitaxel and hemostatic radiotherapy were inefficient and he died seven months after the first symptoms...
September 5, 2016: Rare Tumors
https://www.readbyqxmd.com/read/27472701/concomitant-etoposide-and-cisplatin-provided-improved-survival-compared-with-docetaxel-and-cisplatin-in-patients-with-locally-advanced-non-small-cell-lung-cancer-treated-with-chemoradiotherapy
#2
Fatma Sen, Makbule Tambas, Kubra Ozkaya, Murat Emin Guveli, Rumeysa Ciftci, Berker Ozkan, Ethem Nezih Oral, Esra Kaytan Saglam, Pinar Saip, Alper Toker, Adalet Demir, Pinar Firat, Adnan Aydiner, Yesim Eralp
Presently, there is no consensus regarding which chemotherapy regimen is best to administer with radiotherapy in patients with locally advanced non-small-cell lung cancer (LA-NSCLC). Herein, our aim was to compare the outcome of patients treated with either etoposide-cisplatin (EP) or docetaxel-cisplatin (DP) in this curative setting.Patients treated with either EP or DP and concurrent radiotherapy from 2004 to2012 were identified and their detailed medical records and follow-up information were obtained for analysis in this retrospective study...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27334838/t-lak-cell-originated-protein-kinase-topk-as-a-prognostic-factor-and-a-potential-therapeutic-target-in-ovarian-cancer
#3
Yuji Ikeda, Jae-Hyun Park, Takashi Miyamoto, Naofumi Takamatsu, Taigo Kato, Akiko Iwasa, Shuhei Okabe, Yuichi Imai, Keiichi Fujiwara, Yusuke Nakamura, Kosei Hasegawa
Background; We aimed to clarify the clinical significance of TOPK (T-lymphokine-activated killer cell-originated protein kinase) expression in ovarian cancer and evaluate the possible effect of TOPK inhibitors, OTS514 and OTS964, on ovarian cancer cells. Methods; TOPK expression was examined by immunohistochemistry using 163 samples with epithelial ovarian cancer (EOC). TOPK protein level and FOXM1 transcriptional level in ovarian cancer cell lines were examined by western blot and RT-PCR, respectively. Half-maximum inhibitory concentration (IC50) values against TOPK inhibitors were examined by MTT assay...
June 22, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27325851/ovarian-cancer-risk-factors-by-histologic-subtype-an-analysis-from-the-ovarian-cancer-cohort-consortium
#4
Nicolas Wentzensen, Elizabeth M Poole, Britton Trabert, Emily White, Alan A Arslan, Alpa V Patel, V Wendy Setiawan, Kala Visvanathan, Elisabete Weiderpass, Hans-Olov Adami, Amanda Black, Leslie Bernstein, Louise A Brinton, Julie Buring, Lesley M Butler, Saioa Chamosa, Tess V Clendenen, Laure Dossus, Renee Fortner, Susan M Gapstur, Mia M Gaudet, Inger T Gram, Patricia Hartge, Judith Hoffman-Bolton, Annika Idahl, Michael Jones, Rudolf Kaaks, Victoria Kirsh, Woon-Puay Koh, James V Lacey, I-Min Lee, Eva Lundin, Melissa A Merritt, N Charlotte Onland-Moret, Ulrike Peters, Jenny N Poynter, Sabina Rinaldi, Kim Robien, Thomas Rohan, Dale P Sandler, Catherine Schairer, Leo J Schouten, Louise K Sjöholm, Sabina Sieri, Anthony Swerdlow, Anna Tjonneland, Ruth Travis, Antonia Trichopoulou, Piet A van den Brandt, Lynne Wilkens, Alicja Wolk, Hannah P Yang, Anne Zeleniuch-Jacquotte, Shelley S Tworoger
PURPOSE: An understanding of the etiologic heterogeneity of ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, and lifestyle factors by histologic subtype in the Ovarian Cancer Cohort Consortium (OC3). PATIENTS AND METHODS: Among 1.3 million women from 21 studies, 5,584 invasive epithelial ovarian cancers were identified (3,378 serous, 606 endometrioid, 331 mucinous, 269 clear cell, 1,000 other)...
August 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27230992/mage-a1-6-%C3%A2-expression-in-patients-with-head-and-neck-squamous-cell-carcinoma-impact-on-clinical-patterns-and-oncologic-outcomes
#5
Sang Tae Noh, Hyoung Shin Lee, Soo Jin Lim, Sung Won Kim, Hee Kyung Chang, Junghwan Oh, Chang-Ho Jeon, Jong Wook Park, Kang Dae Lee
BACKGROUND: Various subtypes of melanoma-associated antigens (MAGEs) are expressed in the tumor tissues of patients with head and neck squamous cell carcinoma (HNSCC). However, little data are currently available on how the gene expression of MAGEs impacts clinical patterns and oncologic outcomes. We have therefore evaluated the expression of MAGE-A1-6 (A1-6) subtypes in tumor tissues of patients with HNSCC and the clinical impact of this expression. METHODS: This was a retrospective review of 53 patients with histologically proven HNSCC of the oral cavity, oropharynx, larynx, or hypopharynx who underwent both treatment and analysis by reverse transcription (RT)-PCR assay with a common primer to identify the expression of MAGE-A1-6 subtypes in the tumor tissue...
May 26, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26960462/factors-predicting-lapatinib-efficacy-in-her-2-metastatic-breast-carcinoma-does-it-work-better-in-different-histologic-subtypes
#6
S S Göksu, H Bozcuk, L Koral, B Çakar, S Gündüz, A M Tatlı, D Arslan, M Uysal, M Koçer, M Artaç, B Karabulut, H S Coşkun, M Özdoğan, B Savaş
CONTEXT: Introduction of trastuzumab, a recombinant monoclonal antibody against the extracellular domain of HER-2, is a cornerstone in the treatment of HER-2+ breast carcinoma. However, many cancers that have an initial response to trastuzumab will progress some time later. After progression on trastuzumab-based first-line treatment, there are several options. Although TDM-1 (Trastuzumab emtansine) has prolonged progression-free survival (PFS) and overall survival in patients previously treated with trastuzumab and taxane, it is still not available in Turkey...
October 2015: Indian Journal of Cancer
https://www.readbyqxmd.com/read/26838208/p53-expression-helps-identify-high-risk-oral-tongue-pre-malignant-lesions-and-correlates-with-patterns-of-invasive-tumour-front-and-tumour-depth-in-oral-tongue-squamous-cell-carcinoma-cases
#7
Thangaraj Soundara Viveka, Vidyarani Shyamsundar, Arvind Krishnamurthy, Pratibha Ramani, Vijayalakshmi Ramshankar
Oral tongue squamous cell carcinoma (OTSCC) is the most common oral cancer subtype with a maximum propensity for regional spread. Our objective was to study if p53 expression might have any correlation with aggressive patterns of invasion within oral tongue cancers as well as with the histologically identified degree of oral tongue dysplasia. p53 immunoexpression was studied using immunohistochemistry in early staged OTSCCs (n=155), oral tongue dysplasias, (n=29) and oral tongue normal specimens (n=10) and evaluated for correlations with histological and clinicopathological parameters...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26833519/non-melanoma-skin-cancer
#8
Liezel L Griffin, Faisal Rehman Ali, John T Lear
Non-melanoma skin cancer (NMSC) comprises basal cell carcinoma (BCC) and squamous cell carcinoma, together with a host of rare tumours. NMSC is the commonest malignancy among Caucasians and its incidence continues to rise annually. Exposure to UV radiation initiates approximately 90% of NMSC, causing malignant transformation of keratinocytes and suppression of the inflammatory response. Risk factors include sun exposure and immunosuppression. There are several subtypes of BCC, although histological overlap is common...
February 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/26794930/everolimus-versus-sunitinib-for-patients-with-metastatic-non-clear-cell-renal-cell-carcinoma-aspen-a-multicentre-open-label-randomised-phase-2-trial
#9
RANDOMIZED CONTROLLED TRIAL
Andrew J Armstrong, Susan Halabi, Tim Eisen, Samuel Broderick, Walter M Stadler, Robert J Jones, Jorge A Garcia, Ulka N Vaishampayan, Joel Picus, Robert E Hawkins, John D Hainsworth, Christian K Kollmannsberger, Theodore F Logan, Igor Puzanov, Lisa M Pickering, Christopher W Ryan, Andrew Protheroe, Christine M Lusk, Sadie Oberg, Daniel J George
BACKGROUND: Non-clear cell renal cell carcinomas are histologically and genetically diverse kidney cancers with variable prognoses, and their optimum initial treatment is unknown. We aimed to compare the mTOR inhibitor everolimus and the VEGF receptor inhibitor sunitinib in patients with non-clear cell renal cell carcinoma. METHODS: We enrolled patients with metastatic papillary, chromophobe, or unclassified non-clear cell renal cell carcinoma with no history of previous systemic treatment...
March 2016: Lancet Oncology
https://www.readbyqxmd.com/read/26668515/possible-association-between-hepatitis-c-virus-and-malignancies-different-from-hepatocellular-carcinoma-a-systematic-review
#10
Sirio Fiorino, Letizia Bacchi-Reggiani, Dario de Biase, Adele Fornelli, Michele Masetti, Andrea Tura, Fabio Grizzi, Matteo Zanello, Laura Mastrangelo, Raffaele Lombardi, Giorgia Acquaviva, Luca di Tommaso, Arrigo Bondi, Michela Visani, Sergio Sabbatani, Laura Pontoriero, Carlo Fabbri, Andrea Cuppini, Annalisa Pession, Elio Jovine
AIM: To summarize the current knowledge about the potential relationship between hepatitis C virus (HCV) infection and the risk of several extra-liver cancers. METHODS: We performed a systematic review of the literature, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) Statement. We extracted the pertinent articles, published in MEDLINE and the Cochrane Library, using the following search terms: neoplasm/cancer/malignancy/tumor/carcinoma/adeno-carcinoma and non-Hodgkin lymphomas, kidney/renal-, cholangio-, pancreatic-, thyroid-, breast-,oral-, skin-, prostate-, lung-, colon-, stomach-, haematologic...
December 7, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26668446/molecular-concept-in-human-oral-cancer
#11
REVIEW
Akhilesh Krishna, Shraddha Singh, Vijay Kumar, U S Pal
The incidence of oral cancer remains high in both Asian and Western countries. Several risk factors associated with development of oral cancer are now well-known, including tobacco chewing, smoking, and alcohol consumption. Cancerous risk factors may cause many genetic events through chromosomal alteration or mutations in genetic material and lead to progression and development of oral cancer through histological progress, carcinogenesis. Oral squamous carcinogenesis is a multistep process in which multiple genetic events occur that alter the normal functions of proto-oncogenes/oncogenes and tumor suppressor genes...
January 2015: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/26632951/five-and-10-year-cause-specific-survival-rates-in-carcinoma-of-the-minor-salivary-gland
#12
H Michael Baddour, Stacey A Fedewa, Amy Y Chen
IMPORTANCE: Previous studies of prognostic factors of carcinoma of the minor salivary gland (MSG) have been limited to single-institution studies and small case series. Thus, limited data are available to guide the head and neck oncologist in counseling patients on the prognosis and management of these malignant neoplasms. OBJECTIVE: To examine 5- and 10-year cause-specific survival (CSS) rates of MSG carcinomas across all histologic subtypes and head and neck tumor subsites...
January 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/26514182/antitumor-activity-of-the-multikinase-inhibitor-regorafenib-in-patient-derived-xenograft-models-of-gastric-cancer
#13
Hung Huynh, Richard Ong, Dieter Zopf
BACKGROUND: Unresectable gastric cancer is associated with poor outcomes, with few treatment options available after failure of cytotoxic chemotherapy. Clinical trials of targeted therapies have generally shown no survival benefit in gastric cancer, with the exceptions of the antibodies ramucirumab (anti-VEGFR2) and trastuzumab (anti-HER2/neu). Given the efficacy of the multikinase inhibitor regorafenib in other gastrointestinal tumors, we investigated its potential in gastric cancer...
2015: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/26381550/cancer-incidence-among-minnesota-taconite-mining-industry-workers
#14
Elizabeth M Allen, Bruce H Alexander, Richard F MacLehose, Heather H Nelson, Gurumurthy Ramachandran, Jeffrey H Mandel
PURPOSE: To evaluate cancer incidence among Minnesota taconite mining workers. METHODS: We evaluated cancer incidence between 1988 and 2010 in a cohort of 40,720 Minnesota taconite mining workers used between 1937 and 1983. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated by comparing numbers of incident cancers with frequencies in the Minnesota Cancer Surveillance System. SIRs for lung cancer by histologic subtypes were also estimated...
November 2015: Annals of Epidemiology
https://www.readbyqxmd.com/read/26273932/oral-contraceptive-use-and-reproductive-characteristics-affect-survival-in-patients-with-epithelial-ovarian-cancer-a-cohort-study
#15
Nonna V Kolomeyevskaya, J Brian Szender, Gary Zirpoli, Albina Minlikeeva, Grace Friel, Rikki A Cannioto, Rachel M Brightwell, Kassondra S Grzankowski, Kirsten B Moysich
OBJECTIVES: Prognostic risk factors influencing survival in patients with epithelial ovarian cancer (EOC) include tumor stage, grade, histologic subtype, debulking, and platinum status. Little is known about the impact of hormonal milieu and reproductive factors before cancer diagnosis on clinical outcome. We sought to evaluate whether oral contraceptive (OC) use carries any prognostic significance on overall survival (OS) in patients with EOC. METHODS: Newly diagnosed patients with EOC, fallopian tube, and primary peritoneal cancers between 1982 and 1998 were prospectively evaluated with a comprehensive epidemiologic questionnaire...
November 2015: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/25910410/the-relationship-between-semaphorin-3c-and-microvessel-density-in-the-progression-of-breast-and-oral-neoplasia
#16
Zachary Cole-Healy, Patricia Vergani, Keith Hunter, Nicola J Brown, Malcolm W R Reed, Carolyn A Staton
This study aimed to identify the expression of semaphorin 3C (SEMA3C) in the normal-metastatic spectrum of breast and oral cancers, and correlate expression with microvessel density (MVD, CD31), a surrogate marker of angiogenesis. Histological analysis revealed that SEMA3C expression was reduced in the development of oral cancer from normal oral tissue (P<0.0001) and expression was inversely correlated with MVD (r=-0.394, P=0.05). In contrast, SEMA3C expression increased in the transition from normal to invasive breast disease in epithelial/tumour cells (P=0...
August 2015: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/25847006/stratifying-tumour-subtypes-based-on-copy-number-alteration-profiles-using-next-generation-sequence-data
#17
Arief Gusnanto, Peter Tcherveniakov, Farag Shuweihdi, Manar Samman, Pamela Rabbitts, Henry M Wood
MOTIVATION: The role of personalized medicine and target treatment in the clinical management of cancer patients has become increasingly important in recent years. This has made the task of precise histological substratification of cancers crucial. Increasingly, genomic data are being seen as a valuable classifier. Specifically, copy number alteration (CNA) profiles generated by next-generation sequencing (NGS) can become a determinant for tumours subtyping. The principle purpose of this study is to devise a model with good prediction capability for the tumours histological subtypes as a function of both the patients covariates and their genome-wide CNA profiles from NGS data...
August 15, 2015: Bioinformatics
https://www.readbyqxmd.com/read/25837263/periodontal-bone-loss-and-risk-of-epithelial-ovarian-cancer
#18
Ana Babic, Elizabeth M Poole, Kathryn L Terry, Daniel W Cramer, Ricardo P Teles, Shelley S Tworoger
PURPOSE: Periodontitis, a chronic inflammatory response to pathogenic bacteria in the oral microbiome, is common among adults. It is associated with several medical conditions, including cardiovascular diseases, and potentially with esophageal, lung, oral, and pancreatic cancer. One of the proposed mechanisms behind these associations is systemic inflammation, which has also been implicated in ovarian cancer etiology. The aim of this study was to evaluate association between ovarian cancer and periodontal bone loss...
June 2015: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/25704618/kag-308-a-newly-identified-ep4-selective-agonist-shows-efficacy-for-treating-ulcerative-colitis-and-can-bring-about-lower-risk-of-colorectal-carcinogenesis-by-oral-administration
#19
Yusuke Watanabe, Takahiko Murata, Masahiro Amakawa, Yoshihide Miyake, Tango Handa, Katsuhiko Konishi, Yasushi Matsumura, Takuji Tanaka, Koji Takeuchi
Agonists for EP4 receptor, a prostaglandin E2 receptor subtype, appear to be a promising therapeutic strategy for ulcerative colitis (UC) due to their anti-inflammatory and epithelial regeneration activities. However, the clinical development of orally-available EP4 agonists for mild to moderate UC has not yet been reported. Furthermore, the possibility of an increased risk of colitis-associated cancer (CAC) through direct proliferative effects on epithelial cells via EP4 signaling has not been ruled out. Recently, we identified KAG-308 as an orally-available EP4-selective agonist...
May 5, 2015: European Journal of Pharmacology
https://www.readbyqxmd.com/read/25656413/reproductive-and-hormone-related-risk-factors-for-epithelial-ovarian-cancer-by-histologic-pathways-invasiveness-and-histologic-subtypes-results-from-the-epic-cohort
#20
MULTICENTER STUDY
Renée T Fortner, Jennifer Ose, Melissa A Merritt, Helena Schock, Anne Tjønneland, Louise Hansen, Kim Overvad, Laure Dossus, Françoise Clavel-Chapelon, Laura Baglietto, Heiner Boeing, Antonia Trichopoulou, Vassiliki Benetou, Pagona Lagiou, Claudia Agnoli, Amalia Mattiello, Giovanna Masala, Rosario Tumino, Carlotta Sacerdote, H B As Bueno-de-Mesquita, N Charlotte Onland-Moret, Petra H Peeters, Elisabete Weiderpass, Inger Torhild Gram, Eric J Duell, Nerea Larrañaga, Eva Ardanaz, María-José Sánchez, M-D Chirlaque, Jenny Brändstedt, Annika Idahl, Eva Lundin, Kay-Tee Khaw, Nick Wareham, Ruth C Travis, Sabina Rinaldi, Isabelle Romieu, Marc J Gunter, Elio Riboli, Rudolf Kaaks
Whether risk factors for epithelial ovarian cancer (EOC) differ by subtype (i.e., dualistic pathway of carcinogenesis, histologic subtype) is not well understood; however, data to date suggest risk factor differences. We examined associations between reproductive and hormone-related risk factors for EOC by subtype in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Among 334,126 women with data on reproductive and hormone-related risk factors (follow-up: 1992-2010), 1,245 incident cases of EOC with known histology and invasiveness were identified...
September 1, 2015: International Journal of Cancer. Journal International du Cancer
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