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S Raponi, I Del Giudice, M Marinelli, J Wang, L Cafforio, C Ilari, A Piciocchi, M Messina, S Bonina, S Tavolaro, M Bordyuh, P Mariglia, N Peragine, F R Mauro, S Chiaretti, S Molica, M Gentile, A Visentin, L Trentin, G M Rigolin, A Cuneo, F Diop, D Rossi, G Gaidano, A Guarini, R Rabadan, R Foà
Background: Chronic lymphocytic leukemia (CLL) has a heterogeneous clinical course. Beside patients requiring immediate treatment, others show an initial indolent phase followed by progression and others do not progress for decades. The latter two subgroups usually display mutated IGHV genes and a favorable FISH profile. Patients and Methods: Patients with absence of disease progression for over 10 years (11-30) from diagnosis were defined as ultra-stable CLL (US-CLL)...
January 22, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
I Del Giudice, G M Rigolin, S Raponi, L Cafforio, C Ilari, J Wang, M Bordyuh, A Piciocchi, M Marinelli, M Nanni, S Tavolaro, M Filetti, A Bardi, E Tammiso, E Volta, M Negrini, E Saccenti, F R Mauro, D Rossi, G Gaidano, A Guarini, R Rabadan, A Cuneo, R Foà
No abstract text is available yet for this article.
February 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
M G Della Porta, E Travaglino, E Boveri, M Ponzoni, L Malcovati, E Papaemmanuil, G M Rigolin, C Pascutto, G Croci, U Gianelli, R Milani, I Ambaglio, C Elena, M Ubezio, M C Da Via', E Bono, D Pietra, F Quaglia, R Bastia, V Ferretti, A Cuneo, E Morra, P J Campbell, A Orazi, R Invernizzi, M Cazzola
The World Health Organization classification of myelodysplastic syndromes (MDS) is based on morphological evaluation of marrow dysplasia. We performed a systematic review of cytological and histological data from 1150 patients with peripheral blood cytopenia. We analyzed the frequency and discriminant power of single morphological abnormalities. A score to define minimal morphological criteria associated to the presence of marrow dysplasia was developed. This score showed high sensitivity/specificity (>90%), acceptable reproducibility and was independently validated...
January 2015: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Franca Nneka Alaribe, Elisa Mazzoni, Gian Matteo Rigolin, Lara Rizzotto, Stefania Maniero, Cecilia Pancaldi, Marco Manfrini, Fernanda Martini, Mauro G Tognon
SV40 footprints were detected in different lymphoproliferative disorders and in blood specimens of healthy donors. However, little is known on the ability of SV40 to infect/transform normal human B-lymphocytes. In this in vitro study, experimental SV40 infection and SV40 Tag transfection of normal human B-lymphocytes from healthy blood donors were carried out. In SV40 infected/transfected purified B-cells, during the time course analyses, viral DNA sequences were detected by PCR, while Tag mRNA and protein were revealed by RT-PCR and immunocytochemistry, respectively...
June 2013: Leukemia Research
M Ciccone, C Agostinelli, G M Rigolin, P P Piccaluga, F Cavazzini, S Righi, M T Sista, O Sofritti, L Rizzotto, E Sabattini, G Fioritoni, S Falorio, C Stelitano, A Olivieri, I Attolico, M Brugiatelli, P L Zinzani, E Saccenti, D Capello, M Negrini, A Cuneo, S Pileri
To better define the significance of proliferation centers (PCs), the morphological hallmark of chronic lymphocytic leukemia (CLL), lymph node biopsies taken from 183 patients were submitted to histopathologic and fluorescence in situ hybridization (FISH) studies using a 5-probe panel on tissue microarrays. Seventy-five cases (40.9%) with confluent PCs were classified as 'PCs-rich' and 108 cases (59.1%) with scattered PCs were classified as 'typical'. Complete FISH data were obtained in 101 cases (55.1%), 79 of which (78...
March 2012: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
T Werlang, C Trippe, G A P Ribeiro, Gustavo Rigolin
We compute the quantum correlation [quantum discord (QD)] and the entanglement (EOF) between nearest-neighbor qubits (spin-1/2) in an infinite chain described by the Heisenberg model (XXZ Hamiltonian) at finite temperatures. The chain is in the thermodynamic limit and thermalized with a reservoir at temperature T (canonical ensemble). We show that QD, in contrast to EOF and other thermodynamic quantities, spotlight the critical points associated with quantum phase transitions (QPT) for this model even at finite T...
August 27, 2010: Physical Review Letters
F Manfredini, G M Rigolin, A M Malagoni, L Catizone, S Mandini, O Sofritti, E Mauro, S Soffritti, B Boari, A Cuneo, P Zamboni, R Manfredini
Haemodialysis patients have few endothelial progenitor cells (EPCs) and an unfavourable cardiovascular outcome. The effects on peripheral blood CD34(+) cells and EPCs of a 6-month walking exercise programme were studied. Thirty dialysis patients (20 males, age 67 +/- 12 years) were prescribed exercise (two daily 10-min home walking sessions at moderate intensity, group E, n = 16) or not prescribed exercise (control, group C, n = 14). On entry and after 6 months peripheral blood CD34(+) cells, EPCs (assessed as CD34(+) cells co-expressing AC133 and vascular endothelial growth factor receptor 2 [VEGFR2], and as endothelial colony-forming units [e-CFU]) and exercise capacity (6-min walking distance, 6MWD) were evaluated...
March 2009: Journal of International Medical Research
P M McCarthy, E C McGee, V H Rigolin, Q Zhao, H Subacius, A L Huskin, S Underwood, B J Kane, I Mikati, G Gang, R O Bonow
OBJECTIVE: Complexity of mitral valve repair for myxomatous disease has led to low adoption. We report initial experience with a new ring designed specifically for myxomatous disease, the Myxo-ETlogix (Edwards Lifesciences LLC, Irvine, Calif). METHODS: From March 15, 2006, through November 19, 2007, 129 patients underwent mitral valve surgery for pure myxomatous disease, and 124 valves (96.1%) were repaired. The Myxo-ETlogix ring was used in 100 cases and the Physio ring (Edwards) in 24...
July 2008: Journal of Thoracic and Cardiovascular Surgery
M G Della Porta, L Malcovati, G M Rigolin, V Rosti, E Bonetti, E Travaglino, E Boveri, A Gallì, S Boggi, M Ciccone, T Pramparo, G Mazzini, R Invernizzi, M Lazzarino, M Cazzola
Circulating endothelial cells (CECs) are associated with neoangiogenesis in various malignant disorders. Using flow cytometry, we studied CECs in 128 patients with myelodysplastic syndrome (MDS). MDS patients had higher CEC levels than controls (P<0.001), and an inverse relationship was found between CECs and international prognostic scoring system risk (r=-0.55, P<0.001). There was a positive correlation between marrow microvessel density and CECs, low-risk patients showing the strongest association (r=0...
March 2008: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
F Manfredini, G M Rigolin, A M Malagoni, S Soffritti, B Boari, F Conconi, G L Castoldi, L Catizone, P Zamboni, R Manfredini
Mobilization of circulating endothelial progenitor cells (EPCs) is increased after acute exercise and training. This study aims to evaluate whether, in a low performance population, EPC levels may be related to exercise capacity in steady state conditions. Study population consisted of sixteen hemodialysis patients. The distance walked in the 6-minute walking test (6 MWD) and the maximal speed attained in an incremental treadmill test were used to assess the exercise capacity. Physical functioning was measured by the scale on the SF36 questionnaire...
May 2007: International Journal of Sports Medicine
Marco Valgimigli, Gian Matteo Rigolin, Corrado Cittanti, Patrizia Malagutti, Salvatore Curello, Gianfranco Percoco, Anna Maria Bugli, Matteo Della Porta, Letizia Zenone Bragotti, Lucia Ansani, Endri Mauro, Arnalda Lanfranchi, Melchiore Giganti, Luciano Feggi, Gianluigi Castoldi, Roberto Ferrari
AIMS: There is increasing evidence that stem cell (SC) mobilization to the heart and their differentiation into cardiac cells is a naturally occurring process. We sought to assess the safety and feasibility of granulocyte-colony stimulating factor (G-CSF) administration in humans to enhance SC mobilization and left ventricle (LV) injury repair during myocardial infarction (MI). METHODS AND RESULTS: Twenty patients with STEMI (mean age, 61+/-10 years), of whom 14 were submitted to primary percutaneous coronary intervention, were randomized to G-CSF (5 microg/kg/day s...
September 2005: European Heart Journal
E Mauro, C Fraulini, G M Rigolin, R Galeotti, R Spanedda, G Castoldi
Tumor necrosis factor alpha (TNF-alpha) seems to play a key role in the pathogenesis of Langerhans' cell histiocytosis (LCH). Thalidomide is an immunomodulator agent of inflammatory cytokines including TNF-alpha. To our knowledge this is the first case of disseminated LCH successfully treated with thalidomide.
February 2005: European Journal of Haematology
Micah J Eimer, Deborah L Ekery, Vera H Rigolin, Robert O Bonow, Mercedes R Carnethon, William G Cotts
Serum B-type natriuretic peptide (BNP) levels reflect myocardial strain and are known to be elevated in patients with heart failure. To determine if BNP levels are elevated in patients with aortic regurgitation, we measured BNP levels in patients with chronic asymptomatic aortic regurgitation and normal left ventricular systolic function.
September 1, 2004: American Journal of Cardiology
Gian Matteo Rigolin, Matteo Della Porta, Maria Ciccone, Anna Maria Bugli, Letizia Zenone Bragotti, Endri Mauro, Chiara Fraulini, Antonella Russo Rossi, Antonella Bardi, Antonio Cuneo, Gianluigi Castoldi
The in vivo effect of recombinant human erythropoietin (rHuEpo) and granulocyte colony-stimulating factor (G-CSF) combined treatment on CD34(+) cells was evaluated by fluorescence in situ hybridization (FISH) in 13 myelodysplastic syndrome (MDS) patients with known cytogenetic abnormalities. After treatment, responsive patients presented a significantly lower proportion of FISH abnormal CD34(+) cells than before treatment (P = 0.003), and in comparison with unresponsive cases (P = 0.007). Response to treatment was associated with a reduced degree of apoptosis in CD34(+) cells (P = 0...
August 2004: British Journal of Haematology
Marco Valgimigli, Gian Matteo Rigolin, Alessandro Fucili, Matteo Della Porta, Olga Soukhomovskaia, Patrizia Malagutti, Anna Maria Bugli, Letizia Zenone Bragotti, Gloria Francolini, Endri Mauro, Gianluigi Castoldi, Roberto Ferrari
BACKGROUND: Peripheral blood CD34(+) cells and circulating endothelial progenitor cells (EPCs) increase in myocardial infarction and vascular injuries as a reflection of endothelial damage. Despite the occurrence of endothelial dysfunction in heart failure (HF), no data are available on EPC mobilization in this setting. We investigated the pattern of CD34(+) cells and EPC mobilization during HF and their correlation with the severity and origin of the disease. METHODS AND RESULTS: Peripheral blood CD34(+) cells (n=91) and EPCs (n=41), assessed both as CD34(+) cells coexpressing AC133 and vascular endothelial growth factor (VEGF) receptor-2 and as endothelial colony-forming units, were studied in HF patients (mean age 67+/-11 years) and 45 gender- and age-matched controls...
September 7, 2004: Circulation
Frank F Seghatol, Dipan J Shah, Silvia Diluzio, David Bello, Maryl R Johnson, William G Cotts, Jenny A O'Donohue, Robert O Bonow, Mihai Gheorghiade, Vera H Rigolin
Beta blockers improve left ventricular (LV) ejection fraction but patient responses are heterogenous. We investigated the role of contractile reserve (CR) in predicting beta-blocker response in ischemic and nonischemic cardiomyopathy. Resting and low-dose dobutamine echocardiograms were recorded in 32 patients with heart failure (LV ejection fraction <or=35%), 18 with ischemic cardiomyopathy (IC), and 14 with idiopathic dilated cardiomyopathy (IDC). A segment was defined as CR positive (CR+) or negative (CR-) based on response to dobutamine...
April 1, 2004: American Journal of Cardiology
A Cuneo, G M Rigolin, R Bigoni, C De Angeli, A Veronese, F Cavazzini, A Bardi, M G Roberti, E Tammiso, P Agostini, M Ciccone, M Della Porta, A Tieghi, L Cavazzini, M Negrini, G Castoldi
Cytogenetic and fluorescence in situ hybridization studies were successfully performed in 217 chronic lymphocytic leukemia (CLL). In all, 13 patients with 6q21 deletion were identified and characterized in comparison with 92 patients with 'favourable' karyotype (normal or 13q-), 69 cases with 'intermediate risk' (1-2 anomalies) and 43 cases with 'unfavourable' karyotype (complex, 11q- or 17p-). Six out of 13 cases with 6q- showed an excess of atypical lymphocytes, a finding confirmed at the histologic level; >20% CD38+ cells were seen in 5/6 cases...
March 2004: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
M C Béné, G Castoldi, W Knapp, G M Rigolin, L Escribano, P Lemez, W-D Ludwig, E Matutes, A Orfao, F Lanza, M van't Veer
The analysis of CD87 (urokinase-type plasminogen activator receptor - uPAR) expression has a potential role in the diagnostic or prognostic work-up of several hematological malignancies, particularly acute leukemia and multiple myeloma. The distribution of CD87 in acute myeloid leukemia (AML) varies according to the FAB subtype (highest expression in M5 and lowest in M0). Functionally, it is conceivable that the expression of CD87 could contribute to the invasive properties of the leukemic cells towards the skin and mucosal tissues as reflected by the clinical behavior of CD87 high cases...
March 2004: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
R Marchetto, I Rigolin, R Rizzato, A Intenti, N Romagnolo, M Tomaini, M Girotto, M G Monesi, G Gastaldo
A survey on the practices related to the management of patients with indwelling urinary catheter was organised in two hospitals and health districts, with the aim of identifying problems or incorrect habits. Thirty-five nurses were interviewed with a questionnaire exploring different practices and procedures related to the catheter care. While practices were overall satisfactory and homogeneous across wards, few problems were identified: the ill defined practice of bladder training before catheter removal; the difficulties in maintaining a closed system; an improper use of sterile sacs...
April 2001: Assistenza Infermieristica e Ricerca: AIR
G M Rigolin, R Bigoni, R Milani, F Cavazzini, M G Roberti, A Bardi, P Agostini, M Della Porta, A Tieghi, N Piva, A Cuneo, G Castoldi
At diagnosis, approximately half of myelodysplastic (MDS) patients presents a normal karyotype by conventional cytogenetic analysis (CCA). Fluorescent in situ hybridization (FISH) is more sensitive than CCA allowing for the detection of minor clones and of submicroscopic lesions. We have analyzed by FISH 101 MDS patients with normal karyotype for the occurrence of the abnormalities which are most frequently observed in MDS (ie -5/5q-, -7/7q-, +8, 17p-). In 18 patients, 15 to 32% of interphase cells were found to carry one FISH abnormality...
December 2001: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
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