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Gian Matteo Rigolin, Elena Saccenti, Cristian Bassi, Laura Lupini, Francesca Maria Quaglia, Maurizio Cavallari, Sara Martinelli, Luca Formigaro, Enrico Lista, Maria Antonella Bardi, Eleonora Volta, Elisa Tammiso, Aurora Melandri, Antonio Urso, Francesco Cavazzini, Massimo Negrini, Antonio Cuneo
No abstract text is available yet for this article.
September 30, 2016: Journal of Hematology & Oncology
Rebecca Voltan, Erika Rimondi, Elisabetta Melloni, Gian Matteo Rigolin, Fabio Casciano, Maria Vittoria Arcidiacono, Claudio Celeghini, Antonio Cuneo, Giorgio Zauli, Paola Secchiero
OBJECTIVE: The aim of this study was to investigate the anti-leukemic activity of the Bruton tyrosine kinase inhibitor Ibrutinib in combination with the small molecule MDM-2 inhibitor Nutlin-3 in preclinical models. METHODS: The potential efficacy of the Ibrutinib/Nutlin-3 combination was evaluated in vitro in a panel of B leukemic cell lines (EHEB, JVM-2, JVM-3, MEC-1, MEC-2) and in primary B-chronic lymphocytic leukemia (B-CLL) patient samples, by assessing cell viability, cell cycle profile, apoptosis and intracellular pathway modulations...
September 20, 2016: Oncotarget
Gian Matteo Rigolin, Elena Saccenti, Cristian Bassi, Laura Lupini, Francesca Maria Quaglia, Maurizio Cavallari, Sara Martinelli, Luca Formigaro, Enrico Lista, Maria Antonella Bardi, Eleonora Volta, Elisa Tammiso, Aurora Melandri, Antonio Urso, Francesco Cavazzini, Massimo Negrini, Antonio Cuneo
BACKGROUND: In chronic lymphocytic leukemia (CLL), next-generation sequencing (NGS) analysis represents a sensitive, reproducible, and resource-efficient technique for routine screening of gene mutations. METHODS: We performed an extensive biologic characterization of newly diagnosed CLL, including NGS analysis of 20 genes frequently mutated in CLL and karyotype analysis to assess whether NGS and karyotype results could be of clinical relevance in the refinement of prognosis and assessment of risk of progression...
September 15, 2016: Journal of Hematology & Oncology
Richard Lee, Patricia Vassallo, Jane Kruse, S Chris Malaisrie, Vera Rigolin, Adin-Cristian Andrei, Patrick McCarthy
BACKGROUND: Elimination of the left atrial appendage (LAA) attempts to reduce stroke in patients with atrial fibrillation (AF). A retrospective review suggests that various surgical techniques are often unsuccessful and may leave a stump or gap. In a pilot study, we prospectively evaluated 3 surgical techniques with long-term follow up to define effectiveness. METHODS: At a single institution, 28 patients undergoing concomitant AF surgery were randomized prospectively into 1 of 3 techniques of LAA elimination: internal suture ligation (IL), external stapled excision (StEx), and surgical excision (SxEx)...
October 2016: Journal of Thoracic and Cardiovascular Surgery
Vera H Rigolin
No abstract text is available yet for this article.
July 2016: JACC. Cardiovascular Imaging
Erica Salaro, Alessia Rambaldi, Simonetta Falzoni, Francesca Saveria Amoroso, Alessia Franceschini, Alba Clara Sarti, Massimo Bonora, Francesco Cavazzini, Gian Matteo Rigolin, Maria Ciccone, Valentina Audrito, Silvia Deaglio, Pablo Pelegrin, Paolo Pinton, Antonio Cuneo, Francesco Di Virgilio
Lymphocyte growth and differentiation are modulated by extracellular nucleotides and P2 receptors. We previously showed that the P2X7 receptor (P2X7R or P2RX7) is overexpressed in circulating lymphocytes from chronic lymphocytic leukemia (CLL) patients. In the present study we investigated the P2X7R/NLRP3 inflammasome axis in lymphocytes from a cohort of 23 CLL patients. P2X7R, ASC and NLRP3 were investigated by Western blot, PCR and transfection techniques. P2X7R was overexpressed and correlated with chromosome 12 trisomy in CLL patients...
2016: Scientific Reports
Kai Lin, Varun Chowdhary, Keith H Benzuly, Clyde W Yancy, Jon W Lomasney, Vera H Rigolin, Allen S Anderson, Jane Wilcox, James Carr, Michael Markl
To systematically investigate the reproducibility of global and segmental left ventricular (LV) velocities derived from tissue phase mapping (TPM). Breath held and ECG synchronized TPM data (spatial/temporal resolution = 2 × 2 mm(2)/20.8 ms) were acquired in 18 healthy volunteers. To analyze scan-rescan variability, TPM was repeated in all subjects during a second visit separated by 16 ± 5 days. Data analysis included LV segmentation, and quantification of global and regional (AHA 16-segment modal) metrics of LV function [velocity-time curves, systolic and diastolic peak and time-to-peak (TTP) velocities] for radial (Vr), long-axis (Vz) and circumferential (VΦ) LV velocities...
August 2016: International Journal of Cardiovascular Imaging
Gian Matteo Rigolin, Francesco Cavazzini, Antonio Cuneo
No abstract text is available yet for this article.
April 21, 2016: New England Journal of Medicine
Francesco Cavazzini, Enrico Lista, Francesca Maria Quaglia, Luca Formigaro, Maurizio Cavallari, Sara Martinelli, Gian Matteo Rigolin, Robin Foà, Antonio Cuneo
No abstract text is available yet for this article.
November 2016: Leukemia & Lymphoma
Rebecca Voltan, Erika Rimondi, Elisabetta Melloni, Paola Gilli, Valerio Bertolasi, Fabio Casciano, Gian Matteo Rigolin, Giorgio Zauli, Paola Secchiero
Metformin and the mitochondrial targeting dichloroacetate (DCA) have recently received attention due to their ability to inhibit anaerobic glycolysis, which renders most cancer cells resistant to apoptosis induction. We observed that Metformin alone exhibited a dose-dependent anti-leukemic activity in both B leukemic cell lines and primary B-chronic lymphocytic leukemia (B-CLL) patients' cells and its anti-leukemic activity was enhanced when used in combination with DCA. In order to overcome the problems of poor bioavailability and cellular uptake, which limit DCA efficacy, we have designed and synthetized cocrystals consisting of Metformin and DCA (Met-DCA) at different stoichiometric ratios...
April 5, 2016: Oncotarget
Matthew J Budoff, Paolo Raggi, George A Beller, Daniel S Berman, Regina S Druz, Shaista Malik, Vera H Rigolin, Wm Guy Weigold, Prem Soman
Increased cardiovascular morbidity and mortality in patients with type 2 diabetes is well established; diabetes is associated with at least a 2-fold increased risk of coronary heart disease. Approximately two-thirds of deaths among persons with diabetes are related to cardiovascular disease. Previously, diabetes was regarded as a "coronary risk equivalent," implying a high 10-year cardiovascular risk for every diabetes patient. Following the original study by Haffner et al., multiple studies from different cohorts provided varying conclusions on the validity of the concept of coronary risk equivalency in patients with diabetes...
February 2016: JACC. Cardiovascular Imaging
Carmen Baldazzi, Simona Luatti, Elisa Zuffa, Cristina Papayannidis, Emanuela Ottaviani, Giulia Marzocchi, Gaia Ameli, Maria Antonella Bardi, Laura Bonaldi, Rossella Paolini, Carmela Gurrieri, Gian Matteo Rigolin, Antonio Cuneo, Giovanni Martinelli, Michele Cavo, Nicoletta Testoni
Chromosomal rearrangements involving 3q26 are recurrent findings in myeloid malignancies leading to MECOM overexpression, which has been associated with a very poor prognosis. Other 3q abnormalities have been reported and cryptic MECOM rearrangements have been identified in some cases. By fluorescence in situ hybridization (FISH) analysis, we investigated 97 acute myeloid leukemia/myelodysplastic syndrome patients with various 3q abnormalities to determine the role and the frequency of the involvement of MECOM...
April 2016: Genes, Chromosomes & Cancer
Gian Matteo Rigolin, Ilaria del Giudice, Luca Formigaro, Elena Saccenti, Sara Martinelli, Maurizio Cavallari, Enrico Lista, Elisa Tammiso, Eleonora Volta, Laura Lupini, Cristian Bassi, Antonella Bardi, Olga Sofritti, Giulia Daghia, Francesco Cavazzini, Marilisa Marinelli, Simona Tavolaro, Anna Guarini, Massimo Negrini, Robin Foà, Antonio Cuneo
To clarify whether karyotype aberrations (KA) involving regions not covered by the standard fluorescence in situ hybridization (FISH) panel have independent prognostic relevance, we evaluated KA by conventional cytogenetics in a learning cohort (LC; n = 166) and a validation cohort (VC; n = 250) of untreated chronic lymphocytic leukemia (CLL) patients. In the VC, novel mitogens were used to improve metaphase generation and TP53, NOTCH1, and SF3B1 mutations were assessed. KA undetected by FISH were found in 35 and 35% of the cases in the LC and VC, respectively...
December 2015: Genes, Chromosomes & Cancer
Davide Rossi, Lodovico Terzi-di-Bergamo, Lorenzo De Paoli, Michaela Cerri, Guido Ghilardi, Annalisa Chiarenza, Pietro Bulian, Carlo Visco, Francesca R Mauro, Fortunato Morabito, Agostino Cortelezzi, Francesco Zaja, Francesco Forconi, Luca Laurenti, Ilaria Del Giudice, Massimo Gentile, Iolanda Vincelli, Marina Motta, Marta Coscia, Gian Matteo Rigolin, Alessandra Tedeschi, Antonino Neri, Roberto Marasca, Omar Perbellini, Carol Moreno, Giovanni Del Poeta, Massimo Massaia, Pier Luigi Zinzani, Marco Montillo, Antonio Cuneo, Valter Gattei, Robin Foà, Gianluca Gaidano
Fludarabine, cyclophosphamide, and rituximab (FCR) has represented a significant treatment advancement in chronic lymphocytic leukemia (CLL). In the new scenario of targeted agents, there is an increasing interest in identifying patients who gain the maximum benefit from FCR. In this observational multicenter retrospective analysis of 404 CLL patients receiving frontline FCR, the combination of three biomarkers that are widely tested before treatment (IGHV mutation status, 11q deletion and 17p deletion; available in 80% of the study cohort) allowed to identify a very low-risk category of patients carrying mutated IGHV genes but neither 11q or 17p deletion that accounted for 28% of all cases...
October 15, 2015: Blood
M E Miranda, K A Olivieri, F J F Rigolin, A A de Vasconcellos
The rehabilitation of an unesthetic smile in the anterior maxilla is always a clinical challenge, especially when an improper shape and size, old restorations, and unesthetic shading are present. In addition, an irregular gingival zenith contour in the anterior maxilla can affect the smile's harmony. Thus, detailed treatment planning is needed to define a functional and esthetic prosthetic rehabilitation. This study describes a clinical case in which a 55-year-old woman was rehabilitated using Digital Smile Design planning and full ceramic crowns (metal free) in the anterior zone of the maxilla and mandible...
January 2016: Operative Dentistry
Brett F Duncan, Patrick M McCarthy, Jane Kruse, Adin-Cristian Andrei, Zhi Li, Hyde M Russell, Travis O Abicht, Vera H Rigolin, James D Thomas, Charles J Davidson, Robert O Bonow, S Chris Malaisrie
OBJECTIVE: Paravalvular regurgitation is a known complication after transcatheter and sutureless aortic valve replacement. Paravalvular regurgitation also may develop in patients undergoing percutaneous mitral valve replacement. There are few studies on contemporary surgical valve replacement for comparison. We sought to determine the contemporary occurrence of paravalvular regurgitation after conventional surgical valve replacement. METHODS: We performed a single-center retrospective database review involving 1774 patients who underwent valve replacement surgery from April 2004 to December 2012: aortic in 1244, mitral in 386, and combined aortic and mitral in 144...
October 2015: Journal of Thoracic and Cardiovascular Surgery
Adin-Cristian Andrei, Ajay Yadlapati, S Chris Malaisrie, Jyothy J Puthumana, Zhi Li, Vera H Rigolin, Marla Mendelson, Colleen Clennon, Jane Kruse, Paul W M Fedak, James D Thomas, Jennifer A Higgins, Daniel Rinewalt, Robert O Bonow, Patrick M McCarthy
Gender disparities in short- and long-term outcomes have been documented in cardiac and valvular heart surgery. However, there is a paucity of data regarding these differences in the bicuspid aortic valve (BAV) population. The aim of this study was to examine gender-specific differences in short- and long-term outcomes after surgical aortic valve (AV) replacement in patients with BAV. A retrospective analysis was performed in 628 consecutive patients with BAV who underwent AV surgery from April 2004 to December 2013...
July 15, 2015: American Journal of Cardiology
Delio José Mora, Laila Rigolin Fortunato, Leonardo Eurípedes Andrade-Silva, Kennio Ferreira-Paim, Ivonete Helena Rocha, Rakel Rocha Vasconcelos, David Nascimento Silva-Teixeira, Gabriel Antonio Nogueira Nascentes, Mario León Silva-Vergara
Cryptococcal meningitis (CM) remains as common life-threatening AIDS-defining illness mainly in resource-limited settings. Previous reports suggested that baseline cytokine profiles can be associated to fungal burden and clinical outcome. This study aimed to evaluate the baseline cytokine profiles in AIDS patients with CM and its relation with the outcome at weeks 2 and 10. Thirty AIDS patients with CM diagnosed by cerebrospinal fluid (CSF) Cryptococcus neoformans positive culture, India ink stain and cryptococcal antigen test were prospectively evaluated...
2015: PloS One
Nishath Quader, Charles J Davidson, Vera H Rigolin
There is considerable interest in percutaneous closure of perivalvular leaks without the need for repeat surgery. Successful percutaneous closure of these defects requires extensive planning and coordination before and during the procedure. However, there is no standardized description of valve pathology in the presence of a prosthetic valve, which adds to the challenge of communication. Transesophageal echocardiography is ideally suited to guide percutaneous mitral valve procedures, because of the proximity of the mitral valve to the esophagus...
May 2015: Journal of the American Society of Echocardiography
Emmanouil Athanasakis, Elisabetta Melloni, Gian Matteo Rigolin, Chiara Agnoletto, Rebecca Voltan, Diego Vozzi, Elisa Piscianz, Ludovica Segat, Simeone Dal Monego, Antonio Cuneo, Paola Secchiero, Giorgio Zauli
By using next generation sequencing, we have analyzed 108 B chronic lymphocytic leukemia (B-CLL) patients. Among genes involved in the TP53 pathway, we found frequent mutations in ATM (n=18), TP53 (n=10) and NOTCH1 (n=10) genes, rare mutations of NOTCH2 (n=2) and CDKN1A/p21 (n=1) and no mutations in BAX, MDM2, TNFRSF10A and TNFRSF10B genes. The in vitro treatment of primary B-CLL cells with the activator of p53 Nutlin-3 induced the transcription of p53 target genes, without significant differences between the B-CLL without mutations and those harboring either ATM or NOTCH1mutations...
December 30, 2014: Oncotarget
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