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Aerobic resistence

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https://www.readbyqxmd.com/read/28331161/isolation-of-cyanobacterial-mutants-exhibiting-growth-defects-under-microoxic-conditions-by-transposon-tagging-mutagenesis-of-synechocystis-sp-pcc-6803
#1
Kazuki Terauchi, Riho Sobue, Yuho Furutani, Rina Aoki, Yuichi Fujita
Cyanobacteria are photosynthetic prokaryotes that perform oxygenic photosynthesis by extracting electrons from water, with the generation of oxygen as a byproduct. Cyanobacteria use oxygen not only for respiration to produce energy in the dark but also for biosynthesis of various metabolites, such as heme and chlorophyll. Oxygen levels dynamically fluctuate in the field environments, from hyperoxic at daytime to almost anaerobic at night. Thus, adaptation to anaerobiosis should be important for cyanobacteria to survive in low-oxygen and anaerobic environments...
March 22, 2017: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/28330267/treatment-of-landfill-leachate-using-asbr-combined-with-zeolite-adsorption-technology
#2
Chi Kim Lim, Ta Wee Seow, Chin Hong Neoh, Muhamad Hanif Md Nor, Zaharah Ibrahim, Ismail Ware, Siti Hajar Mat Sarip
Sanitary landfilling is the most common way to dispose solid urban waste; however, improper landfill management may pose serious environmental threats through discharge of high strength polluted wastewater also known as leachate. The treatment of landfill leachate to fully reduce the negative impact on the environment, is nowadays a challenge. In this study, an aerobic sequencing batch reactor (ASBR) was proposed for the treatment of locally obtained real landfill leachate with initial ammoniacal nitrogen and chemical oxygen demand (COD) concentration of 1800 and 3200 mg/L, respectively...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28323065/the-impact-of-fecal-sample-processing-on-prevalence-estimates-for-antibiotic-resistant-escherichia-coli
#3
Sylvia Omulo, Eric T Lofgren, Maina Mugoh, Moshe Alando, Joshua Obiya, Korir Kipyegon, Gilbert Kikwai, Wilson Gumbi, Samuel Kariuki, Douglas R Call
Investigators often rely on studies of Escherichia coli to characterize the burden of antibiotic resistance in a clinical or community setting. To determine if prevalence estimates for antibiotic resistance are sensitive to sample handling and interpretive criteria, we collected presumptive E. coli isolates (24 or 95 per stool sample) from a community in an urban informal settlement in Kenya. Isolates were tested for susceptibility to nine antibiotics using agar breakpoint assays and results were analyzed using generalized linear mixed models...
March 18, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28323020/metabolic-reprogramming-in-cancer-cells-consequences-on-ph-and-tumour-progression-integrated-therapeutic-perspectives-with-dietary-lipids-as-adjuvant-to-anticancer-treatment
#4
REVIEW
Jean-François Dumas, Lucie Brisson, Stéphan Chevalier, Karine Mahéo, Gaëlle Fromont, Driffa Moussata, Pierre Besson, Sébastien Roger
While tumours arise from acquired mutations in oncogenes or tumour-suppressor genes, it is clearly established that cancers are metabolic diseases characterized by metabolic alterations in tumour cells, and also non-tumour cells of the host organism resulting in tumour cachexia and patient weakness. In this review, we aimed at delineating details by which metabolic alterations in cancer cells, characterized by mitochondrial bioenergetics deregulations and the preference for aerobic glycolysis, are critical parameters controlling the aggressive progression of tumours...
March 17, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28319589/exercise-improves-v-combining-dot-above-o-2max-and-body-composition-in-adt-treated-prostate-cancer-patients
#5
Bradley A Wall, Daniel A Galvão, Naeem Fatehee, Dennis R Taaffe, Nigel Spry, David Joseph, Jeffrey J Hebert, Robert U Newton
INTRODUCTION: Prostate cancer is the most common cancer in men and patients treated with androgen deprivation therapy (ADT) experience unfavourbale changes in body composition and associated metabolic complications, which can increase the risk of cardiovascular disease. We examined the effect of a 6-month program of aerobic and resistance exercise aimed at improving body composition and cardiorespiratory health in this population. METHODS: Ninety-seven men (43-90 years) with localized prostate cancer receiving ADT were randomized to either exercise (EX, n=50) or usual care (CON, n=47)...
March 18, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28316595/effects-of-copper-addition-on-copper-resistance-antibiotic-resistance-genes-and-intl1-during-swine-manure-composting
#6
Yanan Yin, Jie Gu, Xiaojuan Wang, Wen Song, Kaiyu Zhang, Wei Sun, Xin Zhang, Yajun Zhang, Haichao Li
Copper is one of the most abundant heavy metals present in swine manure. In this study, a laboratory-scale aerobic composting system was amended with Cu at three levels (0, 200, and 2000 mg kg(-1), i.e., control, Cu200, and Cu2000 treatments, respectively) to determine its effect on the fate of copper resistance genes [copper resistance genes (CRGs): pcoA, cusA, copA, and tcrB], antibiotic resistance genes [antibiotic resistance genes (ARGs): erm(A) and erm(B)], and intl1. The results showed that the absolute abundances of pcoA, tcrB, erm(A), erm(B), and intl1 were reduced, whereas those of copA and cusA increased after swine manure composting...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28316570/isometric-exercise-training-for-managing-vascular-risk-factors-in-mild-cognitive-impairment-and-alzheimer-s-disease
#7
REVIEW
Nicole C L Hess, Neil A Smart
Alzheimer's disease (AD) is the most common form of dementia diagnosed amongst the elderly. Mild cognitive impairment (MCI) is a condition often indicative of the earliest symptomatology of AD with 10%-15% of MCI patients reportedly progressing to a diagnosis of AD. Individuals with a history of vascular risk factors (VRF's) are considered high risk candidates for developing cognitive impairment in later life. Evidence suggests that vascular injury resulting from untreated VRF's promotes progression from MCI to AD and exacerbates the severity of dementia in AD, and neuroimaging studies have found that the neurodegenerative processes associated with AD are heavily driven by VRF's that promote cerebral hypoperfusion...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28314935/a-disease-with-a-sweet-tooth-exploring-the-warburg-effect-in-alzheimer-s-disease
#8
REVIEW
Anna Atlante, Lidia de Bari, Antonella Bobba, Giuseppina Amadoro
After more than 80 years from the revolutionary discoveries of Otto Warburg, who observed high glucose dependency, with increased glycolysis and lactate production regardless of oxygen availability in most cancer cells, the 'Warburg effect' returns to the fore in neuronal cells affected by Alzheimer's disease (AD). Indeed, it seems that, in the mild phase of AD, neuronal cells "prefer" to use the energetically inefficient method of burning glucose by glycolysis, as in cancer, proving to become resistant to β-amyloid (Aβ)-dependent apoptosis...
March 17, 2017: Biogerontology
https://www.readbyqxmd.com/read/28304092/mediation-of-cognitive-function-improvements-by-strength-gains-after-resistance-training-in-older-adults-with-mild-cognitive-impairment-outcomes-of-the-study-of-mental-and-resistance-training
#9
Yorgi Mavros, Nicola Gates, Guy C Wilson, Nidhi Jain, Jacinda Meiklejohn, Henry Brodaty, Wei Wen, Nalin Singh, Bernhard T Baune, Chao Suo, Michael K Baker, Nasim Foroughi, Yi Wang, Perminder S Sachdev, Michael Valenzuela, Maria A Fiatarone Singh
OBJECTIVES: To determine whether improvements in aerobic capacity (VO2peak ) and strength after progressive resistance training (PRT) mediate improvements in cognitive function. DESIGN: Randomized, double-blind, double-sham, controlled trial. SETTING: University research facility. PARTICIPANTS: Community-dwelling older adults (aged ≥55) with mild cognitive impairment (MCI) (N = 100). INTERVENTION: PRT and cognitive training (CT), 2 to 3 days per week for 6 months...
March 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28302430/antimicrobial-copper-alloys-decreased-bacteria-on-stethoscope-surfaces
#10
Michael G Schmidt, Rachel E Tuuri, Arif Dharsee, Hubert H Attaway, Sarah E Fairey, Keith T Borg, Cassandra D Salgado, Bruce E Hirsch
BACKGROUND: Stethoscopes may serve as vehicles for transmission of bacteria among patients. The aim of this study was to assess the efficacy of antimicrobial copper surfaces to reduce the bacterial concentration associated with stethoscope surfaces. METHODS: A structured prospective trial involving 21 health care providers was conducted at a pediatric emergency division (ED) (n = 14) and an adult medical intensive care unit located in tertiary care facilities (n = 7)...
March 13, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28302402/novel-benzimidazolyl-tetrahydroprotoberberines-design-synthesis-antimicrobial-evaluation-and-multi-targeting-exploration
#11
Ponmani Jeyakkumar, Han-Bo Liu, Lavanya Gopala, Yu Cheng, Xin-Mei Peng, Rong-Xia Geng, Cheng-He Zhou
A series of novel benzimidazolyl tetrahydroprotoberberines were conveniently designed and efficiently synthesized from berberine via direct cyclization of tetrahydroprotoberberine aldehyde and o-phenylene diamines under metal-free aerobic oxidation. All the new compounds were characterized by IR, (1)H NMR, (13)C NMR and HRMS spectra. The antimicrobial evaluation revealed that the 5-fluorobenzimidazolyl derivative 5b was the most active antibacterial and antifungal molecule with broad spectrum in comparison to Berberine, Chloromycin, Norfloxacin and Fluconazole...
February 28, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28301568/toxicity-of-spinosad-to-temephos-resistant-aedes-aegypti-populations-in-brazil
#12
Luciana Dos Santos Dias, Maria de Lourdes da Graça Macoris, Maria Teresa Macoris Andrighetti, Vanessa Camargo Garbeloto Otrera, Adriana Dos Santos Dias, Luiz Guilherme Soares da Rocha Bauzer, Cynara de Melo Rodovalho, Ademir Jesus Martins, José Bento Pereira Lima
The mosquito Aedes aegypti is the primary vector of different arboviruses and represents a major public health problem. Several Brazilian populations of Ae. aegypti have developed resistance to temephos, the most used organophosphate larvicide. New tools which are less harmful to the environment and safer for humans are becoming increasingly important to control this insect vector. Spinosad, an aerobic fermentation product of a soil actinobacteria, has a favorable environmental profile. It presents selective insecticide properties, a mechanism of action that differs from those of many synthetic chemical insecticides...
2017: PloS One
https://www.readbyqxmd.com/read/28299401/sodium-lauryl-ether-sulfate-sles-degradation-by-nitrate-reducing-bacteria
#13
Ana M S Paulo, Rozelin Aydin, Mauricio R Dimitrov, Harm Vreeling, Ana J Cavaleiro, Pedro A García-Encina, Alfons J M Stams, Caroline M Plugge
The surfactant sodium lauryl ether sulfate (SLES) is widely used in the composition of detergents and frequently ends up in wastewater treatment plants (WWTPs). While aerobic SLES degradation is well studied, little is known about the fate of this compound in anoxic environments, such as denitrification tanks of WWTPs, nor about the bacteria involved in the anoxic biodegradation. Here, we used SLES as sole carbon and energy source, at concentrations ranging from 50 to 1000 mg L(-1), to enrich and isolate nitrate-reducing bacteria from activated sludge of a WWTP with the anaerobic-anoxic-oxic (A(2)/O) concept...
March 15, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28296056/potential-of-bisbenzimidazole-analogs-toward-metronidazole-resistant-trichomonas-vaginalis-isolates
#14
Travis Korosh, Emmanuel Bujans, Mary Morada, Canan Karaalioglu, Jean Jacques Vanden Eynde, Annie Mayence, Tien L Huang, Nigel Yarlett
A bisoxyphenylene-bisbenzimidazole series with increasing aliphatic chain length (CH2 to C10 H20 ) containing a meta (m) or para (p) benzimidazole linkage to the phenylene ring was tested for ability to inhibit the growth of metronidazole susceptible (C1) and refractory (085) Trichomonas vaginalis isolates under aerobic and anaerobic conditions. Compound 3m, 2,2'-[α,ω-propadiylbis(oxy-1,3-phenylene)]bis-1H-benzimidazole, displayed a 5.5-fold lower minimum inhibitory concentration (MIC) towards T. vaginalis isolate 085 than metronidazole under aerobic growth conditions, (26 μM compared to 145 μM)...
March 10, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28292300/clinical-outcomes-and-glycaemic-responses-to-different-aerobic-exercise-training-intensities-in-type-ii-diabetes-a-systematic-review-and-meta-analysis
#15
Aimee Grace, Erick Chan, Francesco Giallauria, Petra L Graham, Neil A Smart
AIMS: To establish if aerobic exercise training is associated with beneficial effects on clinical outcomes and glycaemic profile in people with type II diabetes. METHODS: A systematic search was conducted to identify studies through a search of MEDLINE (1985 to Sept 1, 2016, Cochrane Controlled Trials Registry (1966 to Sept 1, 2016), CINAHL, SPORTDiscus and Science Citation Index. The search strategy included a mix of MeSH and free text terms for related key concepts...
March 14, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28290889/-platelet-metabolism-in-clopidogrel-resistant-and-sensitive-patients-with-ischemic-heart-disease
#16
I Yu Grinshtein, A A Savchenko, Yu I Grinshtein, I V Filonenko, A A Kosinova
OBJECTIVE: to investigate relationship between activity of platelet nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) dependent dehydrogenases in patients with ischemic heart disease (IHD) after coronary artery bypass grafting (CABG) and their sensitivity to clopidogrel. MATERIAL AND METHODS: We studied 51 male patients with chronic IHD before and after CABG. Control group comprised 35 healthy men. In IHD patients spontaneous and induced platelet aggregation was measured by aggregometry before CABG (in 2 weeks after cessation of antiplatelet drugs), after CABG during therapy with clopidogrel (75 mg/day), and in 6 months after surgery...
October 2016: Kardiologiia
https://www.readbyqxmd.com/read/28289833/central-roles-of-iron-in-the-regulation-of-oxidative-stress-in-the-yeast-saccharomyces-cerevisiae
#17
Ryo Matsuo, Shogo Mizobuchi, Maya Nakashima, Kensuke Miki, Dai Ayusawa, Michihiko Fujii
Oxygen is essential for aerobic organisms but causes cytotoxicity probably through the generation of reactive oxygen species (ROS). In this study, we screened for the genes that regulate oxidative stress in the yeast Saccharomyces cerevisiae, and found that expression of CTH2/TIS11 caused an increased resistance to ROS. CTH2 is up-regulated upon iron starvation and functions to remodel metabolism to adapt to iron starvation. We showed here that increased resistance to ROS by CTH2 would likely be caused by the decreased ROS production due to the decreased activity of mitochondrial respiration, which observation is consistent with the fact that CTH2 down-regulates the mitochondrial respiratory proteins...
March 13, 2017: Current Genetics
https://www.readbyqxmd.com/read/28289730/indirect-interspecies-regulation-transcriptional-and-physiological-responses-of-a-cyanobacterium-to-heterotrophic-partnership
#18
Hans C Bernstein, Ryan S McClure, Vera Thiel, Natalie C Sadler, Young-Mo Kim, William B Chrisler, Eric A Hill, Donald A Bryant, Margaret F Romine, Janet K Jansson, Jim K Fredrickson, Alexander S Beliaev
The mechanisms by which microbes interact in communities remain poorly understood. Here, we interrogated specific interactions between photoautotrophic and heterotrophic members of a model consortium to infer mechanisms that mediate metabolic coupling and acclimation to partnership. This binary consortium was composed of a cyanobacterium, Thermosynechococcus elongatus BP-1, which supported growth of an obligate aerobic heterotroph, Meiothermus ruber strain A, by providing organic carbon, O2, and reduced nitrogen...
March 2017: MSystems
https://www.readbyqxmd.com/read/28289572/human-listeriosis-presenting-as-breast-abscess-report-of-a-rare-case
#19
Venkataramana Kandi
An abscess is defined as a collection of pus in various tissues of the body including skin and other organs. Abscesses most commonly are formed on the skin under the armpits, groin areas, and rectal areas. Most abscesses involve microbial infections with few remaining sterile. The treatment of abscesses includes both medical and surgical intervention. In the era of multidrug resistance, isolation and identification of the causative microbe and testing for antimicrobial susceptible patterns assume greater significance for the better management of patients, thereby reducing the resultant morbidity and mortality...
February 1, 2017: Curēus
https://www.readbyqxmd.com/read/28288611/benefits-of-resistance-exercise-in-lean-women-with-fibromyalgia-involvement-of-igf-1-and-leptin
#20
Jan L Bjersing, Anette Larsson, Annie Palstam, Malin Ernberg, Indre Bileviciute-Ljungar, Monika Löfgren, Björn Gerdle, Eva Kosek, Kaisa Mannerkorpi
BACKGROUND: Chronic pain and fatigue improves by exercise in fibromyalgia (FM) but underlying mechanisms are not known. Obesity is increased among FM patients and associates with higher levels of pain. Symptom improvement after aerobic exercise is affected by body mass index (BMI) in FM. Metabolic factors such as insulin-like growth factor 1 (IGF-1) and leptin may be involved. In this study, the aim was to evaluate the role of metabolic factors in lean, overweight and obese women during resistance exercise, in relation to symptom severity and muscle strength in women with FM...
March 14, 2017: BMC Musculoskeletal Disorders
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