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https://www.readbyqxmd.com/read/28526997/nafld-as-a-sexual-dimorphic-disease-role-of-gender-and-reproductive-status-in-the-development-and-progression-of-nonalcoholic-fatty-liver-disease-and-inherent-cardiovascular-risk
#1
REVIEW
Stefano Ballestri, Fabio Nascimbeni, Enrica Baldelli, Alessandra Marrazzo, Dante Romagnoli, Amedeo Lonardo
Nonalcoholic fatty liver disease (NAFLD) spans steatosis through nonalcoholic steatohepatis, cirrhosis, and hepatocellular carcinoma (HCC) associated with striking systemic features and excess cardiovascular and liver-related mortality. The pathogenesis of NAFLD is complex and multifactorial. Endocrine derangements are closely linked with dysmetabolic traits. For example, in animal and human studies, female sex is protected from dysmetabolism thanks to young individuals' ability to partition fatty acids towards ketone body production rather than very low density lipoprotein (VLDL)-triacylglycerol, and to sex-specific browning of white adipose tissue...
May 19, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28525263/yellow-and-orange-fluorescent-proteins-with-tryptophan-based-chromophores
#2
Nina G Bozhanova, Mikhail S Baranov, Karen S Sarkisyan, Roman Gritсenko, Konstantin V Mineev, Svetlana V Golodukhina, Nadezhda S Baleeva, Konstantin A Lukyanov, Alexander S Mishin
Rapid development of new microscopy techniques exposed the need for genetically encoded fluorescent tags with special properties. Recent works demonstrated the potential of fluorescent proteins with tryptophan-based chromophores. We applied rational design and random mutagenesis to the monomeric red fluorescent protein FusionRed and found two groups of mutants carrying tryptophan-based chromophore: with yellow (535 nm) or orange (565 nm) emission. On the basis of the properties of proteins, a model synthetic chromophore, and a computational modelling we concluded that the presence of a ketone-containing chromophore in different isomeric forms can explain the observed yellow and orange phenotypes...
May 19, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28524922/3-4-alkadienyl-ketones-via-the-palladium-catalyzed-decarboxylative-allenylation-of-3-oxocarboxylic-acids
#3
Tonghao Zhu, Shengming Ma
In this communication, we report a palladium-catalyzed decarboxylative allenylation of benzyl carbonates and tert-butyl carbonates of 2,3-allenols with 3-oxocarboxylic acids. The reaction provides a new and straightforward approach to 3,4-dienyl ketones under mild conditions.
May 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28524100/cs%C3%A2-co%C3%A2-initiated-trifluoro-methylation-of-chalcones-and-ketones-for-practical-synthesis-of-trifluoromethylated-tertiary-silyl-ethers
#4
Cheng Dong, Xing-Feng Bai, Ji-Yuan Lv, Yu-Ming Cui, Jian Cao, Zhan-Jiang Zheng, Li-Wen Xu
It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom-economic process for this anionic trifluoromethylation of non-enolisable aldehydes and ketones.
May 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28523779/arylative-intramolecular-allylation-of-ketones-with-1-3-enynes-enabled-by-catalytic-alkenyl-to-allyl-1-4-rhodium-i-migration
#5
Benjamin M Partridge, Michael Callingham, William Lewis, Hon Wai Lam
Alkenyl-to-allyl 1,4-rhodium(I) migration enables the generation of nucleophilic allylrhodium(I) species by remote C-H activation. This new mode of reactivity was employed in the diastereoselective reaction of arylboron reagents with substrates containing a 1,3-enyne tethered to a ketone, to give products containing three contiguous stereocenters. The products can be obtained in high enantioselectivities using a chiral sulfur-alkene ligand.
May 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28523727/synthesis-and-antineoplastic-evaluation-of-mitochondrial-complex-ii-succinate-dehydrogenase-inhibitors-derived-from-atpenin-a5
#6
Hezhen Wang, Bader Huwaimel, Kshitij Verma, James Miller, Todd Germain, Nihar Kinarivala, Dimitri Pappas, Paul Brookes, Paul Charles Trippier
Mitochondrial complex II (CII) is an emerging target for numerous human diseases. Sixteen analogues of the CII inhibitor natural product atpenin A5 were prepared to evaluate the structure-activity relationship of the C-5 pyridine side chain. The side chain ketone moiety was determined to be pharmacophoric, engendering a bioactive conformation. Analogue 16c displayed CII IC50 = 64 nM, retained selectivity for CII over mitochondrial complex I (>156-fold) and possessed a ligand-lipophilicity efficiency of 5...
May 18, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28521671/the-anticonvulsant-effects-of-ketogenic-diet-on%C3%A2-epileptic-seizures-and-potential-mechanisms
#7
Yifan Zhang, Jingwei Xu, Yingchao Zhang, Wei Yang, Bingjin Li
Epilepsy is one of the most commonly diagnosed neurologic disorders with characteristics of epileptic seizures. Although the multitude of anticonvulsant drugs has been developed, recurrent epileptic seizures remain intractable and contribute to the serious morbidity worldwide. Recently, increasing studies have established the beneficial effects of ketogenic diet (KD) on epileptic seizure reduction. Both basic experiments and clinical trials demonstrated that KD significantly reduced seizure frequency with mild adverse effects...
May 17, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28521105/tert-butyl-nitrite-mediated-domino-synthesis-of-isoxazolines-and-isoxazoles-from-terminal-aryl-alkenes-and-alkynes
#8
Prasenjit Sau, Sourav Kumar Santra, Amitava Rakshit, Bhisma K Patel
A sequential construction of C-C, C-O, C=N and C=O bonds from alkenes leading to the direct synthesis of isoxazolines in the presence of tert-butyl nitrite, quinoline and Sc(OTf)3 catalyst in DCE at 80 oC has been accomplished. An unprecedented consecutive three CH functionalisations of two styrenes are involved during this isoxazoline synthesis. In this radical mediated reaction one half of the aryl alkene is converted into intermediate 2-nitro ketone which serve as a 1,3-dipolarophile and undergo cycloaddition with the other half of unreacted aromatic terminal alkene...
May 18, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28518206/organocatalytic-hydroborylation-promoted-by-n-heterocyclic-olefins
#9
Christian Hering-Junghans, Ian C Watson, Michael J Ferguson, Robert McDonald, Eric Rivard
New complexes containing N-heterocyclic vinylene-stabilized [B2H5](+) fragments were prepared, and surprisingly it was found that the precursor N-heterocyclic olefins (NHOs) could promote the mild (room temperature) catalytic hydroborylation of ketones and aldehydes. This finding represents an important addition to the burgeoning field of non-metal mediated catalysis.
May 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28518187/in-vitro-shock-absorption-tests-on-implant-supported-crowns-influence-of-crown-materials-and-luting-agents
#10
Martin Rosentritt, Sibylle Schneider-Feyrer, Michael Behr, Verena Preis
PURPOSE: To investigate the force absorption capacity of implant-supported crowns made of different restorative materials and connected to abutments with different luting agents. MATERIALS AND METHODS: Molar crowns were milled of different computer-aided design/computer-aided manufacture materials (n = 8 crowns per material): polymethyl methacrylate, polyether ether ketone, composite, lithium disilicate, titanium, and zirconia. Crowns were mounted on titanium implant replicas using different luting agents: uncemented, temporarily cemented (zinc oxide-eugenol cement), conventionally cemented (zinc oxide phosphate cement), and adhesively bonded...
May 18, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28516206/identification-expression-and-characterization-of-an-r-%C3%AF-transaminase-from-capronia-semiimmersa
#11
César Iglesias, Paola Panizza, Sonia Rodriguez Giordano
Chiral amines are essential precursors in the production of biologically active compounds, including several important drugs. Among the biocatalytic strategies that have been developed for their synthesis, the use of ω-transaminases (ω-TA) appears as an attractive alternative allowing the stereoselective amination of prochiral ketones. However, the problems associated with narrow substrate specificity, unfavourable reaction equilibrium and expensive amine donors still hamper its industrial application. The search for novel enzymes from nature can contribute to expand the catalytic repertoire of ω-TA and help to circumvent some of these problems...
May 17, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28515662/tempo-functionalized-c60-fullerene-deposited-on-gold-surface-for-catalytic-oxidation-of-selected-alcohols
#12
Piotr Piotrowski, Joanna Pawłowska, Jarosław Grzegorz Sadło, Renata Bilewicz, Andrzej Kaim
C60TEMPO10 catalytic system linked to a microspherical gold support through a covalent S-Au bond was developed. The C60TEMPO10@Au composite catalyst had a particle size of 0.5-0.8 μm and was covered with the fullerenes derivative of 2.3 nm diameter bearing ten nitroxyl groups; the organic film showed up to 50 nm thickness. The catalytic composite allowed for the oxidation under mild conditions of various primary and secondary alcohols to the corresponding aldehyde and ketone analogues with efficiencies as high as 79-98%, thus giving values typical for homogeneous catalysis, while retaining at the same time all the advantages of heterogeneous catalysis, e...
2017: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/28514820/-diagnostic-approach-to-manifestation-of-type-1-diabetes-mellitus
#13
Hannes Kalscheuer, Hendrik Lehnert
The incidence of type 1 and type 2 diabetes mellitus has been increasing simultaneously. Formerly, these two patients' populations could be differentiated easily, but now, due to the overlapping of both groups, specified diagnostics are necessary. In order to substantiate a suspicion on diabetes, quantifying venous plasma glucose is the gold standard in diagnostics. As a precaution, determination of the HbA1c and OGTT is recommended. It is not necessary to determinate antibodies in every new case of diabetes...
May 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28514599/a-bioenergetics-systems-evaluation-of-ketogenic-diet-liver-effects
#14
Lewis J Hutfles, Heather M Wilkins, Scott J Koppel, Ian W Weidling, J Eva Selfridge, Eephie Tan, John P Thyfault, Chad Slawson, Aron W Fenton, Hao Zhu, Russell H Swerdlow
Ketogenic diets induce hepatocyte fatty acid oxidation and ketone body production. To further evaluate how ketogenic diets affect hepatocyte bioenergetic infrastructure, we analyzed livers from C57Bl/6J male mice maintained for one month on a ketogenic or standard chow diet. Compared to the standard diet, the ketogenic diet increased cytosolic and mitochondrial protein acetylation and also altered protein succinylation patterns. SIRT3 protein decreased while SIRT5 protein increased, and gluconeogenesis, oxidative phosphorylation, and mitochondrial biogenesis pathway proteins were variably and likely strategically altered...
May 17, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28513753/two-step-conversion-of-carboxylic-esters-into-distally-fluorinated-ketones-via-ring-cleavage-of-cyclopropanol-intermediates-application-of-sulfinate-salts-as-fluoroalkylating-reagents
#15
Yulia A Konik, Marina Kudrjashova, Nele Konrad, Sandra Kaabel, Ivar Järving, Margus Lopp, Dzmitry G Kananovich
Tertiary cyclopropanols easily available from carboxylic esters have been used in the synthesis of distally fluorinated ketones. Cyclopropane ring cleavage reactions in methanol with aqueous tert-butyl hydroperoxide in the presence of a copper(ii) acetate catalyst and sodium triflinate (Langlois reagent) afford β-trifluoromethyl ketones in 16-74% isolated yields. Sodium triflinate serves as a precursor of reactive trifluoromethyl copper species, enabling ring-opening trifluoromethylation, as evidenced by mechanistic studies...
May 17, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28513142/12-13-aziridinyl-epothilones-stereoselective-synthesis-of-trisubstituted-olefinic-bonds-from-methyl-ketones-and-heteroaromatic-phosphonates-and-design-synthesis-and-biological-evaluation-of-potent-antitumor-agents
#16
K C Nicolaou, Derek Rhoades, Yanping Wang, Ruoli Bai, Ernest Hamel, Monette Aujay, Joseph Sandoval, Julia Gavrilyuk
The synthesis and biological evaluation of a series of 12,13-aziridinyl epothilone B analogues is described. These compounds were accessed by a practical, general process that involved a 12,13-olefinic methyl ketone as a starting material obtained by ozonolytic cleavage of epothilone B followed by tungsten-induced deoxygenation of the epoxide moiety. The attachment of the aziridine structural motif was achieved by application of the Ess-Kürti-Falck aziridination, while the heterocyclic side chains were introduced via stereoselective phosphonate-based olefinations...
May 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28512002/cell-surface-g-protein-coupled-receptors-for-tumor-associated-metabolites-a-direct-link-to-mitochondrial-dysfunction-in-cancer
#17
REVIEW
Bojana Ristic, Yangzom D Bhutia, Vadivel Ganapathy
Mitochondria are the sites of pyruvate oxidation, citric acid cycle, oxidative phosphorylation, ketogenesis, and fatty acid oxidation. Attenuation of mitochondrial function is one of the most significant changes that occurs in tumor cells, directly linked to oncogenesis, angiogenesis, Warburg effect, and epigenetics. In particular, three mitochondrial enzymes are inactivated in cancer: pyruvate dehydrogenase (PDH), succinate dehydrogenase (SDH), and 3-hydroxy-3-methylglutaryl CoA synthase-2 (HMGCS2). These enzymes are subject to regulation via acetylation/deacetylation...
May 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28511015/multi-stereocenter-containing-cyclopentanoids-from-ynamides-via-oxazolidinone-controlled-nazarov-cyclization
#18
Narasimhulu Manchala, Hanson Yeu Leuk Law, Daniel Jarrah Kerr, Rohan Volpe, Romain J Lepage, Jonathan M White, Elizabeth H Krenske, Bernard L Flynn
Achieving ready enantioselective access to multi-stereocenter containing cyclopentyl rings is an area of great significance to organic synthesis. In this work we describe a general protocol for accessing multi-stereocenter containing cyclopentanoids from simple N-alkynyloxazolidinones (Ox-ynamides). This protocol involves conversion of Ox-ynamides into Ox-activated divinyl and aryl vinyl ketones that undergo facile Nazarov cyclization with excellent chemo-, regio- and stereocontrol. The Ox auxiliary directs all aspects of reactivity and selectivity, both the electrocyclization and in the subsequent transformations of the resulting oxyallyl intermediate...
May 16, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28510035/ketone-bodies-as-a-possible-adjuvant-to-ketogenic-diet-in-pdhc-deficiency-but-not-in-glut1-deficiency
#19
F Habarou, N Bahi-Buisson, E Lebigot, C Pontoizeau, M T Abi-Warde, A Brassier, K H Le Quan Sang, C Broissand, S Vuillaumier-Barrot, A Roubertie, A Boutron, C Ottolenghi, P de Lonlay
OBJECTIVE: Ketogenic diet is the first line therapy for neurological symptoms associated with pyruvate dehydrogenase deficiency (PDHD) and intractable seizures in a number of disorders, including GLUT1 deficiency syndrome (GLUT1-DS). Because high-fat diet raises serious compliance issues, we investigated if oral L,D-3-hydroxybutyrate administration could be as effective as ketogenic diet in PDHD and GLUT1-DS. METHODS: We designed a partial or total progressive substitution of KD with L,D-3-hydroxybutyrate in three GLUT1-DS and two PDHD patients...
May 17, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28509873/leishmanicidal-activity-and-structure-activity-relationships-of-essential-oil-constituents
#20
Audrey R S T Silva, Ricardo Scher, Flaviane V Santos, Sebastião R Ferreira, Sócrates C H Cavalcanti, Cristiane B Correa, Lilian L Bueno, Ricardo J Alves, Damião P Souza, Ricardo T Fujiwara, Silvio S Dolabella
Several constituents of essential oils have been shown to be active against pathogens such as bacteria, fungi, and protozoa. This study demonstrated the in vitro action of ten compounds present in essential oils against Leishmania amazonensis promastigotes. With the exception of p-cymene, all evaluated compounds presented leishmanicidal activity, exhibiting IC50 between 25.4 and 568.1 μg mL(-1). Compounds with the best leishmanicidal activity presented a phenolic moiety (IC50 between 25.4 and 82.9 μg mL(-1))...
May 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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