keyword
MENU ▼
Read by QxMD icon Read
search

Ketone

keyword
https://www.readbyqxmd.com/read/28651342/emissions-of-volatile-odorous-metabolites-by-clostridium-perfringens-in-vitro-study-using-two-broth-cultures
#1
Nishchal K Sharma, Chuck Keerqin, Shu-Biao Wu, Mingan Choct, Robert A Swick
An in vitro study was carried out to investigate the volatile odorous metabolites produced by necrotic enteritis inducing Clostridium perfringens (Cp) type A field strain (EHE-NE18) cultured in two broth media (thioglycollate broth, brain heart infusion broth) at three levels (0, 103 cfu/mL, 106 cfu/mL) using 2 × 3 factorial arrangement of treatments, with each replicated three times. The culture media with and without Cp was freshly prepared on the day of measurement and the culture headspace concentration of odorants was measured using selected ion-flow tube mass spectrometry (SIFT-MS)...
June 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28651242/chalcogen-substitution-effect-of-oxygen-by-sulfur-exchange-on-structural-and-spectroscopic-properties-of-flavonols
#2
Cécilia Falantin, Aurélien Moncomble, Annaïg Le Person, Jean-Paul Cornard
Quantum chemical calculations using density functional theory have revealed that the substitution of the ketone group by a thioketone one doesn't significantly change the structure of 3-hydroxyflavone. Notably, the strong intramolecular hydrogen bond involving the hydroxyl function is preserved if the O atom is substituted by an S atom, but also by Se or Te atoms. However, fundamental modifications are observed in both absorption and emission electronic spectra upon substitution, particularly the non-fluorescent behavior of the flavothione...
June 17, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28650646/catalytic-conjugate-addition-of-electron-rich-heteroarenes-to-%C3%AE-%C3%AE-disubstituted-enones
#3
Tanner L Metz, Joshua Evans, Levi M Stanley
Catalytic conjugate additions of heteroarenes to β,β-disubstituted enones are reported. Additions of a range of heteroarene nucleophiles, including furans, indoles, a pyrrole, and a thiophene, to a variety of β,β-disubstituted enones occur to form the corresponding ketone products containing heteroarylated, all-carbon quaternary centers in up to 90% yield. These reactions occur under mild reaction conditions in the presence of low loadings of bismuth triflate.
June 26, 2017: Organic Letters
https://www.readbyqxmd.com/read/28650632/transition-metal-free-%C3%AE-csp3-h-methylenation-of-ketones-to-form-c-c-bond-using-dimethyl-sulfoxide-as-carbon-source
#4
Yu-Feng Liu, Peng-Yi Ji, Jing-Wen Xu, Yu-Qun Hu, Qiang Liu, Wei-Ping Luo, Can-Cheng Guo
A direct α-Csp(3)-H methylenation of arylketones to form C=C bond using dimethyl sulfoxide as one-carbon source is achieved under transition metal-free reaction condition. Various aryl ketone derivatives react readily with DMSO, producing the α,β-unsaturated carbonyl compounds in yields of 42 to 90%. This method features a transition metal-free reaction condition, wide substrate scope and using DMSO as novel one-carbon source to form C=C bond, thus providing an efficient and expeditious approach to an important class of α,β-unsaturated carbonyl compounds...
June 26, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28650516/asymmetric-synthesis-of-pyrrolidine-containing-chemical-scaffolds-via-tsuji-trost-allylation-of-n-tert-butanesulfinyl-imines
#5
Rafid Dawood, Irene Georgiou, Ross Wilkie, William Lewis, Robert Andrew Stockman
A simple and efficient asymmetric synthesis of novel sp3-rich pyrrolidine chemical scaffolds over five steps starting from simple ketones is described. Key steps involve the use of tert-butanesulfinamide as a chiral auxiliary to perform an asymmetric Tsuji-Trost allylation, with subsequent cross-metathesis with an acrylate ester and reduction of the sulfinimine/cyclisation of the resulting amine giving the pyrrolidine scaffolds in high yields and diastereoselectivites. By removing the chiral auxiliary and functionalising the ester group, the resulting scaffold core can be further derivatised...
June 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28650099/anionic-extraction-for-efficient-recovery-of-bio-based-2-3-butanediol-a-platform-for-bulk-and-fine-chemicals
#6
Peter Drabo, Till Tiso, Benedikt Heyman, Eda Sarikaya, Paula Gaspar, Jochen Förster, Jochen Büchs, Lars Mathias Blank, Irina Delidovich
2,3-Butanediol (BDO) presents a promising platform molecule for the synthesis of basic and fine chemicals. Biotechnological production of BDO from renewable resources with living microbes enables high concentrations in the fermentation broth. The recovery of the high-boiling BDO from an aqueous fermentation broth presents the subsequent challenge. Here we propose a method for BDO isolation based on a reversible complexation with phenylboronate into an anionic complex. BDO can be recovered by back-extraction into an acidic solution...
June 26, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28649963/the-effect-of-growth-medium-on-i-escherichia-coli-i-pathway-mirrored-into-gc-ms-profiles
#7
Ileana Andreea Ratiu, Tomasz Ligor, Victor Bocos-Bintintan, Hossam Al-Suod, Tomasz Kowalkowski, Katarzyna Rafińska, Boguslaw Buszewski
Escherichia coli (E. coli) is a gram-negative coliform bacterium that is commonly found in the lower intestine of warm-blooded organisms. Most of the strains are harmless, but some serotypes are pathogenic, meaning they can cause illness, either diarrhea or illness outside of the intestinal tract. The aim of this work was to assess which components are generated in case of E. coli target analysis needed. In this purpose our study intends to emphasize the importance of the cultivability and to prove the crucial role of growth media used in bacteria growing...
June 26, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28648084/practical-broadly-applicable-%C3%AE-selective-z-selective-diastereoselective-and-enantioselective-addition-of-allylboron-compounds-to-mono-di-tri-and-polyfluoroalkyl-ketones
#8
Farid W van der Mei, Changming Qin, Ryan J Morrison, Amir H Hoveyda
A practical method for enantioselective synthesis of fluoroalkyl-substituted Z-homoallylic tertiary alcohols has been developed. Reactions may be performed with ketones containing a polylfluoro-, trifluoro-, difluoro-, and monofluoroalkyl group along with an aryl, a heteroaryl, an alkenyl, an alkynyl, or an alkyl substituent. Readily accessible unsaturated organoboron compounds serve as reagents. Transformations were performed with 0.5-2.5 mol % of a boron-based catalyst, generated in situ from a readily accessible valine-derived aminophenol and a Z- or an E-γ-substituted boronic acid pinacol ester...
June 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28648066/effects-of-topography-related-puff-parameters-on-carbonyl-delivery-in-mainstream-cigarette-smoke
#9
Samantha M Reilly, Reema Goel, Zachary T Bitzer, Ryan J Elias, Jonathan Foulds, Joshua Muscat, John P Richie
Smoking topography parameters differ substantially between individual smokers and may lead to significant variation in tobacco smoke exposure and risk for tobacco-caused diseases. However, to date, little is known regarding the impact of individual puff parameters on the delivery of many harmful smoke constituents including carbonyls. To examine this, we determined the effect of altering individual puff parameters on mainstream smoke carbonyl levels in machine-smoked reference cigarettes. Carbonyls including formaldehyde, acetaldehyde, crotonaldehyde, propionaldehyde, methyl ethyl ketone (MEK), acrolein and acetone, were determined in cigarette smoke by HPLC after derivatization with 2,4-dinitrophenylhydrazine (DNPH)...
June 24, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28647176/mitochondrial-oxidative-phosphorylation-efficiency-is-upregulated-during-fasting-in-two-major-oxidative-tissues-of-ducklings
#10
Pierre-Axel Monternier, Loïc Teulier, Jocelyne Drai, Aurore Bourguignon, Delphine Collin-Chavagnac, Frédéric Hervant, Jean-Louis Rouanet, Damien Roussel
Fasted endothermic vertebrates must develop physiological responses to maximize energy conservation and survival. The aim of this study was to determine the effect of 1-wk. fasting in 5-wk. old ducklings (Cairina moschata) from whole-body resting metabolic rate and body temperature to metabolic phenotype of tissues and mitochondrial coupling efficiency. At the level of whole organism, the mass-specific metabolic rate of ducklings was decreased by 40% after 1-wk. of fasting, which was associated with nocturnal Tb declines and shallow diurnal hypothermia during fasting...
June 21, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28646031/metabolism-and-acetylation-contribute-to-leucine-mediated-inhibition-of-cardiac-glucose-uptake
#11
Edith Renguet, Audrey Ginion, Roselle Gélinas, Laurent Bultot, Julien Auquier, Isabelle Robillard Frayne, Caroline Daneault, Jean-Louis Vanoverschelde, Christine Des Rosiers, Louis Hue, Sandrine Horman, Christophe Beauloye, Luc Bertrand
High plasma leucine levels strongly correlate with type 2 diabetes. Studies of muscle cells suggest that leucine alters the insulin response for glucose transport by activating an insulin-negative feedback loop driven by the mammalian target of rapamycin/p70 ribosomal S6 kinase (mTOR/p70S6K) pathway. Here, we examined the molecular mechanism involved in leucine's action on cardiac glucose uptake. Leucine was indeed able to curb glucose uptake after insulin stimulation in both cultured cardiomyocytes and perfused hearts...
June 23, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28644031/tris-cyclopentadienyl-lanthanide-complexes-as-catalysts-for-hydroboration-reaction-toward-aldehydes-and-ketones
#12
Sufang Chen, Dandan Yan, Mingqiang Xue, Yubiao Hong, Yingming Yao, Qi Shen
It was found that homoleptic cyclopentadienyl lanthanide complexes Cp3Ln (Ln = Y (1), Yb (2), Sm (3), Nd (4), La (5), Cp = cyclopentadienyl) can be employed as excellent catalysts for the hydroboration of various aldehydes and ketones toward pinacolborane. These robust lanthanide catalysts exhibited high reactivity with low catalyst loadings (0.01-1 mol %) under mild conditions and good functional group tolerability. These complexes also demonstrated uniquely carbonyl-selective hydroboration in the presence of alkenes and alkynes...
June 23, 2017: Organic Letters
https://www.readbyqxmd.com/read/28640998/oximes-and-hydrazones-in-bioconjugation-mechanism-and-catalysis
#13
Dominik K Kölmel, Eric T Kool
The formation of oximes and hydrazones is employed in numerous scientific fields as a simple and versatile conjugation strategy. This imine-forming reaction is applied in fields as diverse as polymer chemistry, biomaterials and hydrogels, dynamic combinatorial chemistry, organic synthesis, and chemical biology. Here we outline chemical developments in this field, with special focus on the past ∼10 years of developments. Recent strategies for installing reactive carbonyl groups and α-nucleophiles into biomolecules are described...
June 22, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28640624/synthesis-of-4-acylpyrazoles-from-saturated-ketones-and-hydrazones-featured-with-multiple-c-sp3-h-bond-functionalization-c-c-bond-cleavage-and-re-organization
#14
Miaomiao Tian, Xiaonan Shi, Xinying Zhang, Xuesen Fan
In this paper, an efficient and convenient one-pot synthesis of diversely substituted 4-acylpyrazole derivatives via copper-catalyzed one pot cascade reactions of saturated ketones with hydrazones is reported. Mechanistically, the formation of the title compounds involves the in situ formation of an enone intermediate through the dehydrogenation of saturated ketone, and the [2+3] cyclization of enone with hydrazone followed by an aromatization-driven C-C bond cleavage and re-organization. To our knowledge, this should be the first example in which the biologically and pharmaceutically important yet otherwise difficult-to-obtain 4-acylpyrazole derivatives were directly prepared from saturated ketones and hydrazones featured with multiple aliphatic C-H bond functionalization, C-C bond cleavage and re-organization...
June 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28640609/enantioselective-copper-catalyzed-arylation-driven-semi-pinacol-rearrangement-of-allylic-alcohols-with-diaryliodonium-salts
#15
Daniel H Lukamto, Matthew J Gaunt
A copper-catalyzed enantioselective arylative semi-pinacol rearrangement of allylic alcohols using diaryliodonium salts is reported. Chiral Cu(II)-bisoxazoline catalysts initiate an electrophilic alkene arylation, triggering a 1,2-alkyl migration to afford a range of non-racemic spirocyclic ketones with high yields, diastero- and enantioselectivities.
June 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28640461/dynamic-kinetic-spiroketalization-oxa-michael-addition-cascade-of-alkoxyboronates-and-peroxy-acetals-enantio-and-diastereo-selective-synthesis-of-benzannulated-spiroketals
#16
Prasanta Ghorai, Abhisek Midya, Sanjay Maity
A unified dynamic kinetic spiroketalization/ enantioselective oxa-Michael addition cascade of an aromatic ketone tethered to an alkoxyboronate and an enone moiety has been developed using cinchona alkaloid based amino-thiourea/-squaramide organocatalysts to provide isobenzofuran based benzannulated spiroketals with high diastereoselectivities and excellent enantioselectivities. Further, a dynamic kinetic peroxy-hemiacetalization/dynamic kinetic spiroketalization/ enantioselective oxa-Michael addition cascade of above substrates provides the corresponding exo-peroxy benzannulated spiroketals with outstanding enantio- and diastereo-selectivities...
June 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28638409/differential-fasting-plasma-glucose-and-ketone-body-levels-in-ghrko-versus-3xtg-ad-mice-a-potential-contributor-to-aging-related-cognitive-status
#17
Chelsea M Griffith, Lauren N Macklin, Andrzej Bartke, Peter R Patrylo
Cognitive function declines with age and appears to correlate with decreased cerebral metabolic rate (CMR). Caloric restriction, an antiaging manipulation that extends life-span and can preserve cognitive function, is associated with decreased glucose uptake, decreased lactate levels, and increased ketone body (KB) levels in the brain. Since the majority of brain nutrients come from the periphery, this study examined whether the capacity to regulate peripheral glucose levels and KB production differs in animals with successful cognitive aging (growth hormone receptor knockouts, GHRKOs) versus unsuccessful cognitive aging (the 3xTg-AD mouse model of Alzheimer's disease)...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28637015/differential-metabonomic-profiles-of-primary-hepatocellular-carcinoma-tumors-from-alcoholic-liver-disease-hbv-infected-and-hcv-infected-cirrhotic-patients
#18
Ding Cao, Can Cai, Mingxin Ye, Junhua Gong, Menghao Wang, Jinzheng Li, Jianping Gong
Our objective was to comparatively profile the metabolite composition of primary hepatocellular carcinoma (HCC) tumors from alcoholic liver disease (ALD), hepatitis B virus (HBV)-infected, and hepatitis C virus (HCV)-infected cirrhotic patients. Primary HCC tumors were collected from ALD, HBV-infected, and HCV-infected cirrhotic patients (n=20 each). High-resolution magic-angle spinning proton nuclear magnetic resonance spectroscopy and metabonomic data analysis were performed to compare HCC tumors from the three groups...
June 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28636380/a-free-radical-promoted-copper-catalyzed-decarboxylative-alkylation-of-%C3%AE-%C3%AE-unsaturated-carboxylic-acids-with-ich2cf3-and-its-analogues
#19
Yan Zhu, Juwen Gong, Yonghui Wang
A novel and efficient free radical promoted copper-catalyzed decarboxylative alkylation of α,β-unsaturated carboxylic acids with ICH2CF3 and its analogues has been developed. This methodology provides with a convenient access to the synthesis of allylic trifluoromethyl and β-CF3 ketone containing compounds as well as other biologically useful fluorinated molecules and materials.
June 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28636366/oxygenation-via-c-h-c-c-bond-activation-with-molecular-oxygen
#20
Yu-Feng Liang, Ning Jiao
The selective oxidation of organic molecules is a fundamentally important component of modern synthetic chemistry. In the past decades, direct oxidative C-H and C-C bond functionalization has proved to be one of the most efficient and straightforward methods to synthesize complex products from simple and readily available starting materials. Among these oxidative processes, the use of molecular oxygen as a green and sustainable oxidant has attracted considerable attention because of its highly atom-economical, abundant, and environmentally friendly characteristics...
June 21, 2017: Accounts of Chemical Research
keyword
keyword
9609
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"