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https://www.readbyqxmd.com/read/29457850/preparation-aroma-characteristics-and-volatile-compounds-of-flavorings-from-enzymatic-hydrolyzed-rice-bran-protein-concentrate
#1
Supeeraya Arsa, Chockchai Theerakulkait
BACKGROUND: Rice bran is by-product obtained from the rice milling industry. The aims of this research were to add value of rice bran by preparation of enzymatic hydrolyzed rice bran protein concentrate (HRPC) as a flavoring agent and the flavoring which was produced by HRPC has not been discovered. Different drying methods (freeze drying and spray drying) and fructose additions were studied for improvement of rice bran protein sensorial aroma characteristics. RESULTS: the most abundant amino acids in liquid HRPC (LH) were glutamic acid, arginine, aspartic acid and leucine, respectively...
February 19, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29457188/divergent-synthesis-of-functionalized-pyrrolidines-and-%C3%AE-amino-ketones-via-rhodium-catalyzed-switchable-reactions-of-vinyl-aziridines-and-silyl-enol-ethers
#2
Chao-Ze Zhu, Jian-Jun Feng, Junliang Zhang
The control of reaction pathways for selective and enantiospecific synthesis of functionalized pyrrolidines and γ-amino ketones has been realized. Rhodium-catalyzed [3+2] cycloadditions of vinylaziridines and enolsilanes with a bulky silyl group gave functionalized pyrrolidines with moderate to excellent diastereoselectivities, while the reaction of silyl enol ethers with a less bulky silyl group afforded chiral γ-amino ketones in good yields.
February 19, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29455554/synthesis-antitumour-and-antioxidant-activities-of-novel-%C3%AE-%C3%AE-unsaturated-ketones-and-related-heterocyclic-analogues-egfr-inhibition-and-molecular-modelling-study
#3
Walaa M El-Husseiny, Magda A-A El-Sayed, Naglaa I Abdel-Aziz, Adel S El-Azab, Esam R Ahmed, Alaa A-M Abdel-Aziz
New α,β-unsaturated ketones 4a,b; 5a-c; and 6a,b; as well as 4-H pyran 7; pyrazoline 8a,b; isoxazoline 9; pyridine 10-11; and quinoline-4-carboxylic acid 12a,b derivatives were synthesized and evaluated for in vitro antitumour activity against HepG2, MCF-7, HeLa, and PC-3 cancer cell lines. Antioxidant activity was investigated by the ability of these compounds to scavenge the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS•+ ). Compounds 6a, 6b, 7, and 8b exhibited potent antitumour activities against all tested cell lines with [IC50 ] ≅5...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29455073/dimethyl-fumarate-in-a-patient-with-multiple-sclerosis-and-type-1-diabetes-mellitus-the-importance-of-ketonuria
#4
Ewa Krzystanek, Przemyslawa Jarosz-Chobot
BACKGROUND: Dimethyl fumarate (DMF) is approved for use in patients with relapsing-remitting multiple sclerosis (MS). Its mechanism of action is still not well understood, but besides the immunological pathways in MS, it may also affect the metabolism of normally functioning internal organs, tissues and cells. CASE PRESENTATION: We report on the case of 29-year-old woman with satisfactorily-controlled type 1 diabetes (T1D), who was diagnosed as having MS. After administration of DMF she experienced intense, adverse gastro-intestinal reactions together with ketonuria up to 160 mg/dL...
February 7, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29454917/marine-derived-xyloketal-derivatives-exhibit-anti-stress-and-anti-ageing-effects-through-hsf-pathway-in-caenorhabditis-elegans
#5
Jie-Bin Zhou, Ying-Lin Zheng, Yi-Xuan Zeng, Jia-Wei Wang, Zhong Pei, Ji-Yan Pang
Ageing is a complex but universal phenomenon that progressively challenges the homeostasis network and finally leads to the dysfunction of organisms and even death. Previous studies demonstrated that xyloketal B and its derivatives, a series of marine novel ketone compounds, possessed unique antioxidative effects on endothelial and neuronal oxidative injuries. In this study, we examined the effects of xyloketal derivatives on extending lifespan and healthspan of Caenorhabditis elegans. The results showed that most selected xyloketals could protect Caenorhabditis elegans against heat stress and extend the lifespan of worms...
February 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29454692/from-milk-to-cheese-evolution-of-flavor-fingerprint-of-milk-cream-curd-whey-ricotta-scotta-and-ripened-cheese-obtained-during-summer-alpine-pasture
#6
M Bergamaschi, G Bittante
The role of each step of cheese and ricotta making in development of flavor of cheese and other dairy products is not yet well known. The objectives of this study were to characterize volatile organic compounds (VOC) in cheese and ricotta making with bulk milk from cows grazing in a highland area and to evaluate their evolution in the various dairy products and by-products obtained during the production processes. A group of 148 cows was grazed day and night on pasture from June to September. A total of 7 cheese-making sessions were carried out using the bulk milk collected every 2 wk during summer pasturing according to the artisanal procedure used for Malga cheese production...
February 14, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29454073/the-accumulation-of-assembly-intermediates-of-the-mitochondrial-complex-i-matrix-arm-is-reduced-by-limiting-glucose-uptake-in-a-neuronal-like-model-of-melas-syndrome
#7
Guillaume Geffroy, Rayane Benyahia, Samuel Frey, Valerie Desquiret-Dumas, Naig Gueguen, Celine Bris, Sophie Belal, Aurore Inisan, Aurelie Renaud, Arnaud Chevrollier, Daniel Henrion, Dominique Bonneau, Franck Letournel, Guy Lenaers, Pascal Reynier, Vincent Procaccio
Ketogenic diet (KD) which combined carbohydrate restriction and the addition of ketone bodies has emerged as an alternative metabolic intervention used as an anticonvulsant therapy or to treat different types of neurological or mitochondrial disorders including MELAS syndrome. MELAS syndrome is a severe mitochondrial disease mainly due to the m.3243A > G mitochondrial DNA mutation. The broad success of KD is due to multiple beneficial mechanisms with distinct effects of very low carbohydrates and ketones...
February 14, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29453970/proton-nmr-based-serum-metabolic-profile-correlates-with-the-neurological-recovery-in-treated-acute-spinal-cord-injury-asci-subjects-a-pilot-study
#8
Alka Singh, Rajeshwar Nath Srivastava, Ashok Agrahari, Suruchi Singh, Saloni Raj, Tanushri Chatterji, Abbas Ali Mahdi, Ravindra Kumar Garg, Raja Roy
BACKGROUND: Acute Spinal Cord Injury (ASCI) is still having substantial morbidity and mortality despite of advanced therapeutics. Major obstacles are paucity of monitoring tools or biomarkers for severity determination, recovery and prognostication. A prospective case control pilot study with serum 1 H NMR spectroscopic metabolic profiling was carried out to evaluate metabolites perturbations and its relationship with recovery and to see role of stem cells in facilitating neurological recovery...
February 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29453276/entropy-drives-selective-fluorine-recognition-in-the-fluoroacetyl-coa-thioesterase-from-streptomyces-cattleya
#9
Amy M Weeks, Ningkun Wang, Jeffrey G Pelton, Michelle C Y Chang
Fluorinated small molecules play an important role in the design of bioactive compounds for a broad range of applications. As such, there is strong interest in developing a deeper understanding of how fluorine affects the interaction of these ligands with their targets. Given the small number of fluorinated metabolites identified to date, insights into fluorine recognition have been provided almost entirely by synthetic systems. The fluoroacetyl-CoA thioesterase (FlK) from Streptomyces cattleya thus provides a unique opportunity to study an enzyme-ligand pair that has been evolutionarily optimized for a surprisingly high 10 6 selectivity for a single fluorine substituent...
February 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29452266/healthy-brain-aging-interplay-between-reactive-species-inflammation-and-energy-supply
#10
REVIEW
O Garaschuk, H M Semchyshyn, V I Lushchak
Brains' high energy expenditure with preferable utilization of glucose and ketone bodies, defines the specific features of its energy homeostasis. The extensive oxidative metabolism is accompanied by a concomitant generation of high amounts of reactive oxygen, nitrogen, and carbonyl species, which will be here collectively referred to as RONCS. Such metabolism in combination with high content of polyunsaturated fatty acids creates specific problems in maintaining brains' redox homeostasis. While the levels of products of interaction between RONCS and cellular components increase slowly during the first two trimesters of individuals' life, their increase is substantially accelerated towards the end of life...
February 13, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29451991/exogenous-ketone-salts-do-not-improve-cognitive-responses-after-a-high-intensity-exercise-protocol-in-healthy-college-aged-males
#11
Hunter S Waldman, Steven A Basham, Ffi G Price, JohnEric W Smith, Harish Chander, Adam C Knight, Ben M Krings, Matthew J McAllister
This study examined the effects of a D-ß-hydroxybutyrate (ßHB) containing beverage on cognitive and performance measures during a bout of repeated Wingates. Fifteen healthy, college-aged males (mean ± SD age: 23.1 ± 2.4 years, height: 165.4 ± 2.0 cm, mass: 81.4 ± 9.2 kg) volunteered for the present study. Trial 1 consisted of baseline measures and familiarization for the protocol. During trials 2 and 3, subjects reported to the laboratory, after a 10 h fast, and ingested 11.38 grams of ßHB or a placebo (PLA) beverage 30 min before exercise...
February 16, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29451336/electronically-unsaturated-three-coordinated-aluminum-hydride-and-organoaluminum-cations
#12
Billa Prashanth, Mamta Bhandari, Satyam Ravi, K R Shamasundar, Sanjay Singh
New three coordinated and electronically unsaturated aluminum hydride [LAlH]+[HB(C6F5)3]- and aluminum methyl [LAlMe]+[MeB(C6F5)3]- cations have been prepared. The quantitative estimation of Lewis acidity by Gutmann-Beckett method reveals [LAlH]+[HB(C6F5)3]- to be better Lewis acid than B(C6F5)3 and AlCl3 making these compounds ideal catalysts for Lewis acid mediated reactions. To highlight that the work is of fundamental importance, catalytic hydroboration of aliphatic and aromatic aldehydes and ketones have been demonstrated...
February 16, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29447443/inhibitor-bound-dengue-ns2b-ns3pro-reveals-multiple-dynamic-binding-modes
#13
Alan C Gibbs, Ruth Steele, Gaohua Liu, Brett A Tounge, Gaetano Montelione
Dengue virus poses a significant global health threat as the source of increasingly deleterious dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. As no specific antiviral treatment exists for dengue infection, considerable effort is being applied to discover therapies and drugs for maintenance and prevention of these afflictions. The virus is primarily transmitted by mosquitoes, and infection occurs following viral endocytosis by host cells. Upon entering the cell, viral RNA is translated into a large multi-subunit polyprotein which is post-translationally cleaved into mature, structural and non-structural (NS) proteins...
February 15, 2018: Biochemistry
https://www.readbyqxmd.com/read/29446941/ni-catalyzed-regioselective-dicarbofunctionalization-of-unactivated-olefins-by-tandem-cyclization-cross-coupling-and-application-to-the-concise-synthesis-of-lignan-natural-products
#14
Shekhar Kc, Prakash Basnet, Surendra Thapa, Bijay Shrestha, Ramesh Giri
We disclose a (terpy)NiBr2-catalyzed reaction protocol that regioselectively difunctionalizes unactivated olefins with tethered alkyl halides and arylzinc reagents. The reaction shows excellent functional group tolerance (such as ketones, esters, nitriles and halides) and moderate to good level of diastereoselectivity. The current cyclization/cross-coupling also tolerates molecules containing base-sensitive racemizable stereocenters, which are preserved without racemization during reaction. This cyclization/cross-coupling provides rapid access to (arylmethyl)carbo- and heterocyclic scaffolds, which occur widely as structural cores in various natural products and bioactive molecules...
February 15, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29446830/prior-ingestion-of-exogenous-ketone-monoester-attenuates-the-glycemic-response-to-an-oral-glucose-tolerance-test-in-healthy-young-individuals
#15
Etienne Myette-Côté, Helena Neudorf, Hossein Rafiei, Kieran Clarke, Jonathan Peter Little
The main objectives of this study were threefold: (1) To determine whether acute ingestion of K me ; (R)-3-hydroxybutyl (R)-3-hydroxybutyrate impacts plasma glucose levels during a standardized oral glucose tolerance test (OGTT). (2) To compare changes in insulin concentrations and estimates of insulin sensitivity after acute K me supplementation. Twenty healthy participants (n = 10 males/females) aged between 18-35 years took part in a randomized crossover study. After an overnight fast, participants consumed a K me supplement (ΔG®; 0...
February 15, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29446637/%C3%AE-alkylation-of-chiral-sulfinimines-for-constructing-quaternary-chiral-carbons-by-introducing-removable-directing-groups
#16
Shuanglin Qin, Shuangwei Liu, Yuting Cao, Jiangnan Li, Chuanke Chong, Tongtong Liu, Yunhao Luo, Jiyun Hu, Shende Jiang, Honggang Zhou, Guang Yang, Cheng Yang
This study developed a facile and efficient synthetic strategy to construct quaternary chiral centers at the α-position of imines and ketones. High regioselectivity and diastereoselectivity were achieved through the synergetic effect of electron-withdrawing directing groups and N-tert-butyl sulfinamide as chiral auxiliaries. Either of them could be removed under the optimized conditions without any epimerization.
February 15, 2018: Organic Letters
https://www.readbyqxmd.com/read/29446621/oxidative-dehydrogenation-on-nanocarbon-insights-into-the-reaction-mechanism-and-kinetics-via-in-situ-experimental-methods
#17
Wei Qi, Pengqiang Yan, Dang Sheng Su
Sustainable and environmentally benign catalytic processes are vital for the future to supply the world population with clean energy and industrial products. The replacement of conventional metal or metal oxide catalysts with earth abundant and renewable nonmetallic materials has attracted considerable research interests in the field of catalysis and material science. The stable and efficient catalytic performance of nanocarbon materials was discovered at the end of last century, and these materials are considered as potential alternatives for conventional metal-based catalysts...
February 15, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29446501/%C3%AE-hydroxy-ketones-as-masked-ester-donors-in-br%C3%A3-nsted-base-catalyzed-conjugate-additions-to-nitroalkenes
#18
Iurre Olaizola, Teresa E Campano, Igor Iriarte, Silvia Vera, Antonia Mielgo, Jesús M García, José M Odriozola, Mikel Oiarbide, Claudio Palomo
The catalyst-controlled enantioselective direct addition reaction of enolizable esters and related carboxylic acid derivatives to π electrophiles remains a difficult synthetic transformation. In this study, the suitability of α-hydroxy ketones as ester equivalents capable of being activated by bifunctional Brønsted base catalysts in the context of conjugate addition reactions to nitroolefins is demonstrated. The scope of the reaction, which affords the corresponding Michael adducts with very high stereoselectivity (diastereomeric ratio (d...
February 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29446221/stereodivergent-evolution-of-artificial-enzymes-for-the-michael-reaction
#19
Xavier Garrabou Pi, Duncan Stuart Macdonald, Basile I M Wicky, Donald Hilvert
Enzymes are valuable biocatalysts for asymmetric synthesis due to their exacting stereocontrol. Changing the selectivity of an existing catalyst for new applications is, however, challenging. Here we show that, in contrast, the stereoselectivity of an artificial enzyme created by design and directed evolution is readily tunable. We engineered a promiscuous artificial retro-aldolase into four stereocomplementary catalysts for the Michael addition of a tertiary carbanion to an unsaturated ketone. Notably, this selectivity is also preserved with alternative Michael nucleophiles...
February 15, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29445807/base-free-n-alkylation-of-anilines-with-arch-2-oh-and-transfer-hydrogenation-of-aldehydes-ketones-catalyzed-by-the-complexes-of-%C3%AE-5-cp-ir-iii-with-chalcogenated-schiff-bases-of-anthracene-9-carbaldehyde
#20
Pooja Dubey, Sonu Gupta, Ajai K Singh
The condensation of anthracene-9-carbaldehyde with 2-(phenylthio/seleno)ethylamine results in Schiff bases [PhS(CH 2 ) 2 C[double bond, length as m-dash]N-9-C 14 H 9 ](L1) and [PhSe(CH 2 ) 2 C[double bond, length as m-dash]N-9-C 14 H 9 ] (L2). On their reaction with [(η 5 -Cp*)IrCl(μ-Cl)] 2 and CH 3 COONa at 50 °C followed by treatment with NH 4 PF 6 , iridacycles, [(η 5 -Cp*)Ir(L-H)][PF 6 ] (1: L = L1; 2: L = L2), result. The same reaction in the absence of CH 3 COONa gives complexes [(η 5 -Cp*)Ir(L)Cl][PF 6 ] (3-4) in which L = L1(3)/L2(4) ligates in a bidentate mode...
February 15, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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