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https://www.readbyqxmd.com/read/29217634/anthracycline-cardiotoxicity-an-update-on-mechanisms-monitoring-and-prevention
#1
REVIEW
Peter A Henriksen
Anthracycline chemotherapy causes dose-related cardiomyocyte injury and death leading to left ventricular dysfunction. Clinical heart failure may ensue in up to 5% of high-risk patients. Improved cancer survival together with better awareness of the late effects of cardiotoxicity has led to growing recognition of the need for surveillance of anthracycline-treated cancer survivors with early intervention to treat or prevent heart failure. The main mechanism of anthracycline cardiotoxicity is now thought to be through inhibition of topoisomerase 2β resulting in activation of cell death pathways and inhibition of mitochondrial biogenesis...
December 7, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29216947/-effects-of-active-abdominal-compression-decompression-cpr-on-oxygen-metabolism-and-prognosis-in-patients-with-cardiac-arrest
#2
Xin Sha, Sisen Zhang, Hongwei Wang, Yingxin Cen, Wei Song, Jing Li, Lixiang Wang
OBJECTIVE: To analyze the effect of active abdominal compression-decompression cardiopulmonary resuscitation (AACD-CPR) and standard cardiopulmonary resuscitation (STD-CPR) on oxygen metabolism and prognosis of patient with cardiac arrest (CA), and to evaluate the treatment effect of AACD-CPR. METHODS: Patients with CA, CA time less than 30 minutes, and without STD-CPR and AACD-CPR contraindications admitted to the Zhengzhou People's Hospital from October 1st 2015 to May 31st 2017 were enrolled...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29216666/-cardiac-rehabilitation
#3
Bernhard Schwaab
Physical training, psychosocial intervention, nutrition counselling and optimisation of secondary preventive medication to reduce morbidity and mortality of the disease as well as the reintegration into social life and return to work are equivalent goals of cardiac rehabilitation. This requires multifactorial intervention by a multidisciplinary team. In Germany, cardiac rehabilitation starting early after an index event could demonstrate a significant reduction of total mortality, myocardial infarction and hospitalisation during a follow-up of 1-2 years in 5 controlled cohort studies including 12 556 patients after myocardial infarction and CABG surgery...
December 7, 2017: Die Rehabilitation
https://www.readbyqxmd.com/read/29216243/the-obesity-paradox-and-incident-cardiovascular-disease-a-population-based-study
#4
Virginia W Chang, Kenneth M Langa, David Weir, Theodore J Iwashyna
BACKGROUND: Prior work suggests that obesity may confer a survival advantage among persons with cardiovascular disease (CVD). This obesity "paradox" is frequently studied in the context of prevalent disease, a stage in the disease process when confounding from illness-related weight loss and selective survival are especially problematic. Our objective was to examine the association of obesity with mortality among persons with incident CVD, where biases are potentially reduced, and to compare these findings with those based on prevalent disease...
2017: PloS One
https://www.readbyqxmd.com/read/29212812/pharmacologic-prevention-of-incident-atrial-fibrillation-long-term-results-from-the-allhat-antihypertensive-and-lipid-lowering-treatment-to-prevent-heart-attack-trial
#5
Thomas A Dewland, Elsayed Z Soliman, Jose-Miguel Yamal, Barry R Davis, Alvaro Alonso, Christine M Albert, Lara M Simpson, L Julian Haywood, Gregory M Marcus
BACKGROUND: Although atrial fibrillation (AF) guidelines indicate that pharmacological blockade of the renin-angiotensin system may be considered for primary AF prevention in hypertensive patients, previous studies have yielded conflicting results. We sought to determine whether randomization to lisinopril reduces incident AF or atrial flutter (AFL) compared with chlorthalidone in a large clinical trial cohort with extended post-trial surveillance. METHODS AND RESULTS: We performed a secondary analysis of the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial), a randomized, double-blind, active-controlled clinical trial that enrolled hypertensive individuals ≥55 years of age with at least one other cardiovascular risk factor...
December 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29212650/low-nasal-no-in-congenital-heart-disease-with-systemic-right-ventricle-and-postcardiac-transplantation
#6
Phillip S Adams, Maliha Zahid, Omar Khalifa, Brian Feingold, Cecilia W Lo
BACKGROUND: NO bioavailability has not been systematically examined in congenital heart disease (CHD). To assess NO in patients with CHD, we measured nasal NO (nNO) generated by the nasal epithelia, given blood NO is difficult to measure (half-life, <2 ms). Given NO's role in hemodynamic regulation and the association of NO bioavailability with heart failure risk, we hypothesized NO levels may differ with varying severity of CHD physiologic characteristics. METHODS AND RESULTS: Six-hundred eighteen subjects, 483 with CHD and 135 controls, had nNO measured noninvasively via the nares using American Thoracic Society/European Respiratory Society guidelines...
December 6, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29210760/a-pilot-study-of-responses-to-suctioning-among-neonates-on-bubble-nasal-continuous-positive-airway-pressure
#7
Michele Sweet, Debra Armbruster, Erin Bainbridge, Brianna Reiner, Alai Tan, Esther Chipps
BACKGROUND: Maintenance of a patent airway while the neonate is on nasal continuous positive airway pressure (nasal CPAP) requires vigilant monitoring and oral/nasopharyngeal suctioning. Currently, no evidence-based guidelines for safe suctioning in neonates while on bubble nasal CPAP have been published. PURPOSE: (1) To characterize the clinical and behavioral responses of neonates on bubble nasal CPAP in a level III neonatal intensive care unit following routine oral and nasopharyngeal suctioning...
December 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29209824/the-2017-esc-eacts-guidelines-on-the-management-of-valvular-heart-disease-what-is-new-and-what-has-changed-compared-to-the-2012-guidelines
#8
REVIEW
Helmut Baumgartner
Numerous new data on the diagnosis and management of valvular heart disease published since 2012 made an update of the practice guidelines of the European Society of Cardiology and European Association of Cardiothoracic Surgery necessary. This was particularly the case for the use of catheter interventional treatment, indications for intervention in asymptomatic patients, medical treatment and organization of care. This review summarizes the most important changes in the recommendations.
December 5, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29208620/impact-of-electronic-clinical-decision-support-on-adherence-to-guideline-recommended-treatment-for-hyperlipidaemia-atrial-fibrillation-and-heart-failure-protocol-for-a-cluster-randomised-trial
#9
Maya Elizabeth Kessler, Rickey E Carter, David A Cook, Daryl Jon Kor, Paul M McKie, Laurie J Pencille, Marianne R Scheitel, Rajeev Chaudhry
INTRODUCTION: Clinical practice guidelines facilitate optimal clinical practice. Point of care access, interpretation and application of such guidelines, however, is inconsistent. Informatics-based tools may help clinicians apply guidelines more consistently. We have developed a novel clinical decision support tool that presents guideline-relevant information and actionable items to clinicians at the point of care. We aim to test whether this tool improves the management of hyperlipidaemia, atrial fibrillation and heart failure by primary care clinicians...
December 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/29208206/prospective-study-of-nsaids-prescribing-in%C3%A2-saudi-arabia-cardiovascular-and-gastrointestinal-risk-in-patients-with-diabetes%C3%A2-mellitus%C3%A2
#10
Faizan Mazhar, Nafis Haider, Jabeen Sultana, Shahzad Akram, Yousif Ahmed
OBJECTIVES: The purpose of this study was to investigate the patterns of nonsteroidal anti-inflammatory drug (NSAID) prescriptions in diabetes mellitus (DM) patients and to evaluate their suitability based on patient gastrointestinal/cardiovascular (GI/CV) risk profiles. MATERIALS AND METHODS: We retrospectively identified patients with DM, who were seen at a primary care facility from March 1 to 31, 2016. GI risk factors, CV histories, and current medications were recorded...
December 6, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29207946/achieved-systolic-blood-pressure-in-older-people-a-systematic-review-and-meta-analysis
#11
Aline A I Moraes, Cristina P Baena, Taulant Muka, Arjola Bano, Adriana Buitrago-Lopez, Ana Zazula, Bruna O Erbano, Nicolle A Schio, Murilo H Guedes, Wichor M Bramer, Oscar H Franco, José Rocha Faria-Neto
BACKGROUND: It remains unclear into which level the systolic blood pressure (SBP) should be lowered in order to provide the best cardiovascular protection among older people. Hypertension guidelines recommendation on attaining SBP levels <150 mmHg in this population is currently based on experts' opinion. To clarify this issue, we systematically reviewed and quantified available evidence on the impact of achieving different SBP levels <150 mmHg on various adverse outcomes in subjects aged ≥60 years old receiving antihypertensive drug treatment...
December 5, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29207933/prognostic-factors-for-in-hospital-mortality-of-patients-hospitalized-for-acutely-decompensated-heart-failure
#12
Štefica Dvornik, Teodora Zaninović Jurjević, Nikolina Jurjević, Amalija Lekić, Luka Zaputović
Objectives Despite improved treatment during last 20 years, prognosis for patients hospitalized for acutely decompensated heart failure (ADHF) is poor and mortality rates reported for these patients are high. Laboratory results can assist clinicians in evaluation and triaging of patients on hospital admission, and are important for the medical decision-making and prognosis assessments. Recently, new guidelines for the diagnosis and treatment of acute and chronic HF patients were published introducing a new group of patients with mid-range left ventricular ejection fraction (LVEF)...
December 5, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29206961/corrigendum-to-2017-esc-eacts-guidelines-for-the-management-of-valvular-heart-disease-eur-j-cardiothorac-surg-2017-52-616-664
#13
Volkmar Falk, Helmut Baumgartner, Jeroen J Bax, Michele De Bonis, Christian Hamm, Per Johan Holm, Bernard Iung, Patrizio Lancellotti, Emmanuel Lansac, Daniel Rodriguez Muñoz, Raphael Rosenhek, Johan Sjögren, Pilar Tornos Mas, Alec Vahanian, Thomas Walther, Olaf Wendler, Stephan Windecker, Jose Luis Zamorano, Marco Roffi, Ottavio Alfieri, Stefan Agewall, Anders Ahlsson, Emanuele Barbato, Héctor Bueno, Jean-Philippe Collet, Ioan Mircea Coman, Martin Czerny, Victoria Delgado, Donna Fitzsimons, Thierry Folliguet, Oliver Gaemperli, Gilbert Habib, Wolfgang Harringer, Michael Haude, Gerhard Hindricks, Hugo A Katus, Juhani Knuuti, Philippe Kolh, Christophe Leclercq, Theresa A McDonagh, Massimo Francesco Piepoli, Luc A Pierard, Piotr Ponikowski, Giuseppe M C Rosano, Frank Ruschitzka, Evgeny Shlyakhto, Iain A Simpson, Miguel Sousa-Uva, Janina Stepinska, Giuseppe Tarantini, Didier Tchétché, Victor Aboyans
No abstract text is available yet for this article.
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29206731/enteral-feeding-practices-in-infants-with-congenital-heart-disease-across-european-picus-a-european-society-of-pediatric-and-neonatal-intensive-care-survey
#14
Lyvonne N Tume, Reinis Balmaks, Eduardo da Cruz, Lynne Latten, Sascha Verbruggen, Frédéric V Valla
OBJECTIVES: To describe enteral feeding practices in pre and postoperative infants with congenital heart disease in European PICUs. DESIGN: Cross-sectional electronic survey. SETTING: European PICUs that admit infants with congenital heart disease pre- and postoperatively. PARTICIPANTS: One senior PICU physician or designated person per unit. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Fifty-nine PICUs from 18 European countries responded to the survey...
December 4, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29206729/extracorporeal-cardiopulmonary-resuscitation-in-the-pediatric-cardiac-population-in-search-of-a-standard-of-care
#15
Javier J Lasa, Parag Jain, Tia T Raymond, Charles G Minard, Alexis Topjian, Vinay Nadkarni, Michael Gaies, Melania Bembea, Paul A Checchia, Lara S Shekerdemian, Ravi Thiagarajan
OBJECTIVES: Although clinical and pharmacologic guidelines exist for the practice of cardiopulmonary resuscitation in children (Pediatric Advanced Life Support), the practice of extracorporeal cardiopulmonary resuscitation in pediatric cardiac patients remains without universally accepted standards. We aim to explore variation in extracorporeal cardiopulmonary resuscitation procedures by surveying clinicians who care for this high-risk patient population. DESIGN: A 28-item cross-sectional survey was distributed via a web-based platform to clinicians focusing on cardiopulmonary resuscitation practices and extracorporeal membrane oxygenation team dynamics immediately prior to extracorporeal membrane oxygenation cannulation...
December 4, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29205923/home-based-interval-training-increases-endurance-capacity-in-adults-with-complex-congenital-heart-disease
#16
Camilla Sandberg, Magnus Hedström, Karin Wadell, Mikael Dellborg, Anders Ahnfelt, Anna-Klara Zetterström, Amanda Öhrn, Bengt Johansson
OBJECTIVE: The beneficial effects of exercise training in acquired heart failure and coronary artery disease are well known and have been implemented in current treatment guidelines. Knowledge on appropriate exercise training regimes for adults with congenital heart disease is limited, thus further studies are needed. The aim of this study was to examine the effect of home-based interval exercise training on maximal endurance capacity and peak exercise capacity. DESIGN: Randomized controlled trial...
December 4, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/29204949/-stroke-prevention-in-atrial-fibrillation-in-germany-situational-analysis-of-treatment-reality-based-on-retrospective-data
#17
Ulrike Mergenthaler, Karel Kostev, Sven Moosmang, Inga-Marion Thate-Waschke, Sylvia Haas
BACKGROUND: Guideline-based, risk-adjusted therapy with anticoagulants reduce thromboembolic stroke risk in patients with atrial fibrillation (AF). METHOD: This study analyzed use of oral anticoagulation in German AF-patients. Access to anonymized patient records was made via IMS Health Disease Analyzer database (sample size: 113,619 patients with ICD-10 Code I48.-; observation period: 11/2010-10/2013). Results were subsequently extrapolated to all general practitioners' (GPs) and cardiological practices in Germany...
December 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/29204531/axillary-lymph-node-coverage-with-3-dimensional-tangential-field-irradiation-and-correlation-with-heart-and-lung-dose
#18
Geraldine Jacobson, Nicole Bunda-Randall, Sijin Wen, Matthew Miller
Purpose: The American College of Surgeons Oncology Group Z0011 trial indicated no benefit from axillary lymph node (LN) dissection after a positive sentinel LN biopsy in patients receiving breast irradiation, suggesting that level I-II LNs were covered in tangential fields. Methods and materials: We evaluated 50 computed tomography-based tangential breast plans and contoured level I-III axillary LNs using the Radiation Therapy Oncology Group guidelines. The volumes of level I-III LN regions covered by 90% and 95% of the prescription dose (PD) were calculated and correlated with the V20 ipsilateral lung and mean heart dose...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29204335/temporal-trends-in-lipid-testing-among-children-and-adolescents-a-population-based-study
#19
Swetha Sriram, Jennifer L St Sauver, Debra J Jacobson, Chun Fan, Brian A Lynch, Valeria Cristiani, Iftikhar J Kullo, Aida N Lteif, Seema Kumar
Unfavorable lipid levels during childhood are associated with subsequent development of atherosclerotic cardiovascular disease. The American Academy of Pediatrics and National Heart, Lung and Blood Institute in 2011 recommended universal lipid screening for children between ages 9-11 years and between ages 17-21 years. The objective of the study was to determine temporal trends in lipid testing among children and young adults in a mid-western population. The Rochester Epidemiology Project database was used to identify lipid testing in ages 2-21 years (n = 51,176) in the Olmsted County population from January 1, 2008 through December 31, 2014...
December 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29203953/are-heart-failure-and-coronary-artery-bypass-surgery-patients-meeting-physical-activity-guidelines
#20
Bernice C Yates, Bunny Pozehl, Kevin Kupzyk, Crystal M Epstein, Pallav Deka
Purpose: The purpose of this study was to describe subjective and objective physical activity (PA) levels of two groups of cardiovascular patients who were either post-coronary artery bypass graft (CABG) surgery or diagnosed with heart failure (HF). Design: A descriptive comparative design was used for this secondary analysis of data from two prior studies. Methods: A convenience sample of 62 outpatients was used to examine PA objectively (Actiheart accelerometer) and subjectively (PA interview)...
May 2017: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
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