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Ischaemic mitral regurgitation

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https://www.readbyqxmd.com/read/27695015/meta-analysis-of-two-different-surgical-treatments-of-ischaemic-mitral-regurgitation-with-the-same-outcome-mitral-valve-repair-vs-mitral-valve-replacement
#1
H Zhang, Y Liu, J Bin, S Qiu, F Chen
No abstract text is available yet for this article.
2016: Acta Cardiologica
https://www.readbyqxmd.com/read/27585461/repair-or-replace-ischemic-mitral-regurgitation-during-coronary-artery-bypass-grafting-a-meta-analysis
#2
Yushu Wang, Xiuli Shi, Meiqin Wen, Yucheng Chen, Qing Zhang
BACKGROUND: No agreement has been reached for the best surgical treatment for patients with chronic ischemic mitral regurgitation (IMR) undergoing coronary artery bypass grafting (CABG). Our objective was to meta-analyze the clinical outcomes of repair and replacement. METHODS: A computerized search was performed using Pubmed, Embase, Ovid medline and Cochrane Library. The search terms "ischemic or ischaemic" and "mitral valve" and "repair or replacement or annuloplasty" and "coronary artery bypass grafting" were entered as MeSH terms and keywords...
September 1, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27528216/three-dimensional-dynamic-morphology-of-the-mitral-valve-in-different-forms-of-mitral-valve-prolapse-potential-implications-for-annuloplasty-ring-selection
#3
Astrid Apor, Anikó Ilona Nagy, Attila Kovács, Aristomenis Manouras, Péter Andrássy, Béla Merkely
BACKGROUND: Real-time three-dimensional transesophageal echocardiography has increased our understanding of the distinct pathomechanisms underlying functional, ischaemic or degenerative mitral regurgitation. However, potential differences in dynamic morphology between the subtypes of degenerative mitral prolapse have scarcely been investigated. METHODS: In order to compare the dynamic behavior of the different phenotypes of degenerative mitral valve prolapse, real-time three-dimensional transesophageal echocardiography recordings of 77 subjects, 27 with Barlow disease (BD), 32 with Fibroelastic deficiency (FED) and 18 normal controls (NC) were analysed...
2016: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/27522080/pulsed-cavitational-ultrasound-for-non-invasive-chordal-cutting-guided-by-real-time-3d-echocardiography
#4
Olivier Villemain, Wojciech Kwiecinski, Alain Bel, Justine Robin, Patrick Bruneval, Bastien Arnal, Mickael Tanter, Mathieu Pernot, Emmanuel Messas
AIMS: Basal chordae surgical section has been shown to be effective in reducing ischaemic mitral regurgitation (IMR). Achieving this section by non-invasive mean can considerably decrease the morbidity of this intervention on already infarcted myocardium. We investigated in vitro and in vivo the feasibility and safety of pulsed cavitational focused ultrasound (histotripsy) for non-invasive chordal cutting guided by real-time 3D echocardiography. METHODS AND RESULTS: Experiments were performed on 12 sheep hearts, 5 in vitro on explanted sheep hearts and 7 in vivo on beating sheep hearts...
October 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/27357467/minimally-invasive-mitral-valve-repair-for-functional-mitral-regurgitation-in-severe-heart-failure-mitraclip-versus-minimally-invasive-surgical-approach
#5
Tomas Ondrus, Jozef Bartunek, Marc Vanderheyden, Bernard Stockman, Martin Kotrc, Frank Van Praet, Guy Van Camp, Patrick Lecomte, Yujing Mo, Martin Penicka
OBJECTIVES: To compare the outcomes of MitraClip versus minimally invasive surgical mitral valve repair in high-risk patients with significant functional mitral regurgitation (FMR) and severe heart failure in a centre having pilot versus extensive experience with the MitraClip and the minimally invasive surgical approach, respectively. METHODS: The MitraClip group consisted of 24 high-surgical-risk patients [age 75 ± 9 years, 75% males, NYHA III/IV 88%, left ventricular (LV) ejection fraction 31 ± 9%, EuroSCORE II 18 ± 14%], while the surgical group consisted of 48 patients matched for age, NYHA class and LV ejection fraction...
November 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27131928/operative-outcomes-with-myxomatous-mitral-valve-repair-experience-with-586-patients
#6
L Bassin, B Weiss, G Cranney, D Gimpel, P Gilhooly, R Smith, Z Akhunji, P Grant, H Wolfenden
INTRODUCTION: American Heart Association (AHA) guidelines recommend mitral valve repair for myxomatous mitral regurgitation whenever possible to prevent LV dysfunction and early mortality. Here we review our early operative outcomes with mitral valve repair for myxomatous mitral regurgitation. METHODS: We collected data from 586 consecutive patients that underwent mitral repair for myxomatous disease at the Prince Henry and Prince of Wales Hospitals Sydney between 1997 and 2012...
August 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27113393/non-ischaemic-mitral-valve-suture-annuloplasty-late-follow-up-results
#7
Rimantas Benetis, Paulius Orda, Jolanta Justina Vaškelytė, Vytenis Ivanauskas, Eglė Ereminienė, Povilas Jakuška, Loreta Jankauskienė
OBJECTIVE: To evaluate late outcomes after posterior mitral valve (MV) annulus double-suture annuloplasty for degenerative (non-ischaemic) MV insufficiency. DESIGN: Between 2005 and 2011, 138 patients underwent MV repair using posterior MV double-suture annuloplasty and an additional 105 patients underwent tricuspid valve repair. The study protocol included operative mortality, reoperation rate and reasons, as well as echocardiographic parameters at pre- and postoperative and follow-up periods (2-9 years)...
October 2016: Perfusion
https://www.readbyqxmd.com/read/27107264/acute-effect-of-mitraclip-implantation-on-mitral-valve-geometry-in-patients-with-functional-mitral-regurgitation-insights-from-three-dimensional-transoesophageal-echocardiography
#8
Ibtihal Al Amri, Philippe Debonnaire, Frank van der Kley, Martin J Schalij, Jeroen J Bax, Nina Ajmone Marsan, Victoria Delgado
AIMS: Our aim was to evaluate the acute effects of transcatheter edge-to-edge mitral valve repair using the MitraClip device on mitral valve geometry in patients with functional mitral regurgitation (FMR). METHODS AND RESULTS: Forty-two patients (age 73 years [IQ range 66.1-78.0], 55% men, 62% ischaemic FMR) with moderate-to-severe and severe FMR treated with the MitraClip were included. Three-dimensional transoesophageal echocardiography was performed prior to and immediately after MitraClip implantation...
April 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27072008/outcome-of-left-ventricular-surgical-remodelling-after-the-stich-trial
#9
Antonio M Calafiore, Angela L Iaco', Hatim Kheirallah, Azmat A Sheikh, Hussain Al Sayed, Mohammed El Rasheed, Ahmed Allam, Mohammed O Awadi, Juan J Alfonso, Ahmed A Osman, Michele Di Mauro
OBJECTIVES: After the publication of the Surgical Treatment for Ischaemic Heart Failure (STICH) trial, surgical indications to left ventricular surgical remodelling (LVSR) have become more restrictive. The experience we report reflects the changes in the real world after the publication of STICH trial. METHODS: From May 2009 to July 2014, 113 patients underwent LVSR, targeted mainly to the left anterior descending territory (89.4%). Of these, 18 patients (15.9%) were operated on an emergency basis...
October 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27009102/is-valve-repair-preferable-to-valve-replacement-in-ischaemic-mitral-regurgitation-a-systematic-review-and-meta-analysis
#10
REVIEW
Mohammad Yousuf Salmasi, Metesh Acharya, Nada Humayun, Dinnish Baskaran, Stephanie Hubbard, Hunaid Vohra
Ischaemic mitral regurgitation (MR) is associated with poor survival. The favoured surgical option remains debatable. Our aim was to perform a meta-analysis to compare the outcomes of mitral valve repair (MVRp) with replacement (MVR). A literature search was conducted in PubMed, Medline and Ovid using the terms 'ischaemic mitral regurgitation', 'repair' and 'replacement'. The primary outcome measure was 30-day survival. The secondary outcome measures were MR recurrence and reoperation. Out of 310 articles, 18 fulfilled the inclusion criteria...
July 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/26888462/meta-analysis-of-concomitant-mitral-valve-repair-and-coronary-artery-bypass-surgery-versus-isolated-coronary-artery-bypass-surgery-in-patients-with-moderate-ischaemic-mitral-regurgitation
#11
REVIEW
Tomislav Kopjar, Hrvoje Gasparovic, Carlos A Mestres, Davor Milicic, Bojan Biocina
Ischaemic mitral regurgitation (IMR) is a complication of coronary artery disease with normal chordal and leaflet morphology. Controversy surrounds the issue of appropriate surgical management of moderate IMR. With the present meta-analysis, we aimed to determine whether the addition of mitral valve (MV) repair to coronary artery bypass grafting (CABG) improved clinical outcome over CABG alone in patients with moderate IMR. Databases were searched for studies reporting on clinical outcomes after CABG and MV repair or CABG alone for moderate IMR...
August 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/26837899/role-of-cardiac-dyssynchrony-and-resynchronization-therapy-in-functional-mitral-regurgitation
#12
REVIEW
Marco Spartera, Maurizio Galderisi, Donato Mele, Matteo Cameli, Antonello D'Andrea, Andrea Rossi, Sergio Mondillo, Giuseppina Novo, Roberta Esposito, Flavio D'Ascenzi, Roberta Montisci, Sabina Gallina, Alberto Margonato, Eustachio Agricola
Functional mitral regurgitation (FMR) is a common complication of left ventricle (LV) dysfunction and remodelling. Recently, it has been recognized as an independent prognostic factor in both ischaemic and non-ischaemic LV dysfunctions. In this review article, we discuss the mechanisms through which cardiac dyssynchrony is involved in FMR pathophysiologic cascade and how cardiac resynchronization therapy (CRT) can have therapeutic effects on FMR by reverting specific dyssynchrony pathways. We analyse recent clinical trials focusing on CRT impact on FMR in 'real-world' patients, the limits and future perspectives that could eventually generate new predictors of CRT response in terms of FMR reduction...
May 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/26819293/surgical-ventricular-restoration-plus-mitral-valve-repair-in-patients-with-ischaemic-heart-failure-risk-factors-for-early-and-mid-term-outcomes%C3%A2
#13
Serenella Castelvecchio, Alessandro Parolari, Andrea Garatti, Piervincenzo Gagliardotto, Eugenio Mossuto, Alberto Canziani, Lorenzo Menicanti
OBJECTIVES: To assess the early and mid-term outcomes and related predictors in a consecutive series of patients who underwent surgical ventricular restoration (SVR) combined with additional mitral valve (MV) repair. METHODS: From January 2001 to October 2014, 626 patients underwent SVR; of these, 175 (28%, median age 65) had an additional MV repair. Anterior, inferior or diffuse remodelling was present in 124 (71%), 41 (23%) and 10 (6%) patients, respectively. The median ejection fraction was 30%, whereas mitral regurgitation grade was 3...
April 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/26685140/left-ventricular-systolic-function-assessment-in-secondary-mitral-regurgitation-left-ventricular-ejection-fraction-vs-speckle-tracking-global-longitudinal-strain
#14
Vasileios Kamperidis, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
AIMS: Left ventricular (LV) ejection fraction (LVEF) is currently considered for the decision making of patients with mitral regurgitation (MR). However, LVEF represents change in LV volume between end-diastole and end-systole but does not characterize the intrinsic function of the myocardium. In contrast, speckle-tracking global longitudinal strain (GLS) characterizes myocardial deformation. The present study evaluated whether LV GLS may detect further impairment in LV systolic function in dilated cardiomyopathy patients with and without severe secondary MR matched based on LVEF...
March 7, 2016: European Heart Journal
https://www.readbyqxmd.com/read/26483167/mitral-valve-disease-morphology-and-mechanisms
#15
REVIEW
Robert A Levine, Albert A Hagége, Daniel P Judge, Muralidhar Padala, Jacob P Dal-Bianco, Elena Aikawa, Jonathan Beaudoin, Joyce Bischoff, Nabila Bouatia-Naji, Patrick Bruneval, Jonathan T Butcher, Alain Carpentier, Miguel Chaput, Adrian H Chester, Catherine Clusel, Francesca N Delling, Harry C Dietz, Christian Dina, Ronen Durst, Leticia Fernandez-Friera, Mark D Handschumacher, Morten O Jensen, Xavier P Jeunemaitre, Hervé Le Marec, Thierry Le Tourneau, Roger R Markwald, Jean Mérot, Emmanuel Messas, David P Milan, Tui Neri, Russell A Norris, David Peal, Maelle Perrocheau, Vincent Probst, Michael Pucéat, Nadia Rosenthal, Jorge Solis, Jean-Jacques Schott, Ehud Schwammenthal, Susan A Slaugenhaupt, Jae-Kwan Song, Magdi H Yacoub
Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence indicates that the mitral valve is not a passive structure, but--even in adult life--remains dynamic and accessible for treatment. This concept motivates efforts to reduce the clinical progression of mitral valve disease through early detection and modification of underlying mechanisms. Discoveries of genetic mutations causing mitral valve elongation and prolapse have revealed that growth factor signalling and cell migration pathways are regulated by structural molecules in ways that can be modified to limit progression from developmental defects to valve degeneration with clinical complications...
December 2015: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/26384190/treatment-of-secondary-mitral-valve-regurgitation-why-we-need-combined-and-evolving-percutaneous-strategies-to-tackle-this-moving-target
#16
Giuseppe D'Ancona, Stephan Kische, Hüseyin U Agma, Hüseyin Ince
Secondary mitral regurgitation (MR) has a complex pathophysiology that includes global or segmental left ventricular (LV) motion abnormalities (of non-ischaemic or ischaemic origin) leading to impaired leaflet coaptation of a normally structured mitral valve (MV). In this context, the LV functional and geometrical changes result in MV leaflet tethering, MV annulus flattening and the decrement of systolic MV closing forces. In light of its complexity, management of secondary MR remains a challenge. In fact, a long-lasting successful treatment using a single medical device and/or intervention that addresses solely the MV target cannot, at least at the present time, be proposed...
September 2015: EuroIntervention
https://www.readbyqxmd.com/read/26351400/double-row-of-overlapping-sutures-for-downsizing-annuloplasty-decreases-the-risk-of-residual-regurgitation-in-ischaemic-mitral-valve-repair
#17
Francesco Nappi, Cristiano Spadaccio, Massimo Chello, Mario Lusini, Christophe Acar
OBJECTIVES: The aim of this study was to evaluate a novel insertion technique of the prosthetic ring that would further magnify the degree of annulus narrowing, thereby reducing the potential for a residual leak in ischaemic mitral valve repair. METHODS: Thirty-six patients with ischaemic mitral regurgitation (MR) were randomly assigned into two groups. In 18 patients, the prosthetic ring was inserted in the conventional manner with a single row of sutures (control group)...
April 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/26348680/acute-effect-of-mitraclip-implantation-on-mitral-valve-geometry-in-patients-with-functional-mitral-regurgitation-insights-from-three-dimensional-transoesophageal-echocardiography
#18
Ibtihal Al Amri, Philippe Debonnaire, Frank van der Kley, Martin J Schalij, Jeroen J Bax, Nina Ajmone Marsan, Victoria Delgado
AIMS: Our aim was to evaluate the acute effects of transcatheter edge-to-edge mitral valve repair using the MitraClip device on mitral valve geometry in patients with functional mitral regurgitation (FMR). METHODS AND RESULTS: Forty-two patients (age 73 years [IQ range 66.1-78.0], 55% men, 62% ischaemic FMR) with moderate-to-severe and severe FMR treated with the MitraClip were included. Three-dimensional transoesophageal echocardiography was performed prior to and immediately after MitraClip implantation...
April 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/26296413/heterogenous-haemodynamic-effects-of-adaptive-servoventilation-therapy-in-sleeping-patients-with-heart-failure-and-cheyne-stokes-respiration-compared-to-healthy-volunteers
#19
Jens Spießhöfer, Henrik Fox, Roman Lehmann, Christina Efken, Jessica Heinrich, Thomas Bitter, Britta Körber, Dieter Horstkotte, Olaf Oldenburg
This study investigated the haemodynamic effects of adaptive servoventilation (ASV) in heart failure (HF) patients with Cheyne-Stokes respiration (CSR) versus healthy controls. Twenty-seven HF patients with CSR and 15 volunteers were ventilated for 1 h using a new ASV device (PaceWave™). Haemodynamics were continuously and non-invasively recorded at baseline, during ASV and after ventilation. Prior to the actual study, a small validation study was performed to validate non-invasive measurement of Stroke volume index (SVI)...
July 2016: Heart and Vessels
https://www.readbyqxmd.com/read/25800999/basal-chordae-sites-on-the-mitral-valve-determine-the-severity-of-secondary-mitral-regurgitation
#20
Jong-Min Song, Jae-Joong Kim, Tae-Yong Ha, Jae Won Lee, Sung-Ho Jung, Il-Seon Hwang, Inchul Lee, Byung Joo Sun, Dae-Hee Kim, Duk-Hyun Kang, Jae-Kwan Song
OBJECTIVES: To evaluate the variation between individuals in terms of basal chordae (BC) attachment sites on the mitral valve (MV) and the influence of this variation on secondary mitral regurgitation (MR) severity. BACKGROUND: BC-mediated MV tenting is the main cause of secondary MR. METHODS: In this prospective cross-sectional study, 38 consecutive patients with dilated or ischaemic cardiomyopathy who were due for cardiac transplantation underwent preoperative 3D full volume/colour Doppler echocardiography in sinus rhythm, and MV apparatus geometry, LV volume and MR severity were assessed...
July 2015: Heart: Official Journal of the British Cardiac Society
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