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https://www.readbyqxmd.com/read/28820057/impact-of-angiotensin-converting-enzyme-inhibitors-angiotensin-receptors-blockers-on-mortality-in-acute-heart-failure-patients-with-left-ventricular-systolic-dysfunction-in-the-middle-east-observations-from-the-gulf-acute-heart-failure-registry-gulf-care
#1
Ibrahim Al-Zakwani, Kadhim Sulaiman, Jawad A Al-Lawati, Alawi A Alsheikh-Ali, Prashanth Panduranga, Khalid F AlHabib, Jassim Al Suwaidi, Wael Al-Mahmeed, Hussam AlFaleh, Abdelfatah Elasfar, Ahmed Al-Motarreb, Mustafa Ridha, Bassam Bulbanat, Mohammed Al-Jarallah, Nooshin Bazargani, Nidal Asaad, Haitham Amin
AIMS: To evaluate the impact of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptors blockers (ARBs) on in-hospital, 3- and 12-month all-cause mortality in acute heart failure (AHF) patients with left ventricular systolic dysfunction in 7 countries of the Middle East. METHODS AND RESULTS: Data was analysed from 2,683 consecutive patients admitted with AHF and low ventricular ejection fraction (LVEF) (<40%) from 47 hospitals from February to November, 2012...
August 17, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28816537/evaluating-the-prescription-of-angiotensin-converting-enzyme-inhibitors-or-receptor-blockers-in-patients-with-diabetes-in-jordan
#2
Fadia Mayyas, Wa'ed Bataineh, Anan Jarab
OBJECTIVE: The angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are guideline-recommended agents to prevent development and progression of nephropathy and cardiovascular diseases in diabetic Mellitus (DM). The aim of this study was to evaluate the prescription of ACEIs/ARBs in DM patients with guideline indications. METHOD: electronic data files for diabetes patients were retrospectively reviewed at a primary care setting northern Jordan...
August 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28816530/hemoglobin-a1c-blood-pressure-and-ldl-cholesterol-control-among-hispanic-latino-adults-with-diabetes-results-from-the-hispanic-community-health-study-study-of-latinos-hchs-sol
#3
Sarah Stark Casagrande, Larissa Aviles-Santa, Leonor Corsino, Martha L Daviglus, Linda C Gallo, Rebeca A Espinoza Giacinto, Maria M Llabre, Samantha A Reina, Peter J Savage, Neil Schneiderman, Gregory A Talavera, Catherine C Cowie
OBJECTIVE: To determine the prevalence of Hispanic/Latino adults with diabetes who meet target A1c, blood pressure (BP), and LDL cholesterol (LDL-C) recommendations, and ACE (angiotensin-converting enzyme inhibitors)/ARB (angiotensin receptor blocker) and statin medication use, by heritage and sociodemographic and diabetes-related characteristics. METHODS: Data were cross-sectional, collected between 2008-2011, and included adults age 18-74 years who reported a physician diagnosis of diabetes in the Hispanic Community Health Study/Study of Latinos (N=2,148)...
August 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28813079/diffusion-tensor-imaging-of-brain-white-matter-in-huntington-gene-mutation-individuals
#4
Roberta Arb Saba, James H Yared, Thomas M Doring, Med Phys, Vanderci Borges, Henrique Ballalai Ferraz
Objective: To evaluate the role of the involvement of white matter tracts in huntingtin gene mutation patients as a potential biomarker of the progression of the disease. Methods: We evaluated 34 participants (11 symptomatic huntingtin gene mutation, 12 presymptomatic huntingtin gene mutation, and 11 controls). We performed brain magnetic resonance imaging to assess white matter integrity using diffusion tensor imaging, with measurement of fractional anisotropy...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28805480/current-evidence-on-the-use-of-anti-raas-agents-in-congenital-or-acquired-solitary-kidney
#5
Mariadelina Simeoni, Annarita Armeni, Chiara Summaria, Annamaria Cerantonio, Giorgio Fuiano
RATIONAL: The inhibition of renin-angiotensin-aldosterone system (RAAS) is a major strategy for slowing the progression of chronic kidney disease (CKD). The utility of anti-RAAS agents in patients with congenital or acquired solitary kidney is still controversial. OBJECTIVE: A systematic literature review was conducted. MAIN FINDINGS: The conclusions of the few available studies on the topic are homogeneously in agreement with a long-term reno-protective activity of anti-RAAS drugs in patients with solitary kidney, especially if patients are hypertensive or proteinuric...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28805311/mechanistic-model-for-blood-pressure-and-heart-rate-changes-produced-by-telmisartan-in-humans
#6
Dong Woo Chae, Mijeong Son, Yukyung Kim, Hankil Son, Kyungsoo Park
Telmisartan, an angiotensin receptor blocker (ARB), is indicated for the treatment of essential hypertension. This study aimed to develop a mechanistic model of telmisartan drug effect in human using non-invasive markers. Data were acquired from a previous study where telmisartan 80 mg was given once daily for 6 days. Systolic (SBP) and diastolic blood pressure (DBP) and heart rate (HR) were measured before dosing for day 1 to 5 and serially after the last dose. Mean arterial pressure (MAP) and pulse pressure (PP) were calculated from SBP and DBP...
August 14, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28802945/effect-of-dual-compared-to-no-or-single-renin-angiotensin-system-blockade-on-risk-of-renal-replacement-therapy-or-death-in-predialysis-patients-prepare-2-study
#7
Pauline W M Voskamp, Friedo W Dekker, Merel van Diepen, Ellen K Hoogeveen
Current guidelines on hypertension treatment in chronic kidney disease (CKD) patients discourage combined angiotensin-converting enzyme inhibitor (ACEi) and angiotensin II receptor blocker (ARB) use due to the risk of an increased kidney function decline. However, dual compared to single renin-angiotensin system (RAS) blockade may have more efficacy with regard to hypertension and proteinuria. Among incident predialysis patients (CKD 4-5), we compared dual with no or single RAS blockade regarding kidney function decline and risk of renal replacement therapy (RRT) or death...
July 22, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28802138/inhibition-of-bioenergetic-metabolism-by-the-combination-of-metformin-and-2-deoxyglucose-highly-decreases-viability-of-feline-mammary-carcinoma-cells
#8
María Florencia Arbe, Chiara Fondello, Lucrecia Agnetti, Gabriel Martín Álvarez, Matías Nicolás Tellado, Gerardo Claudio Glikin, Liliana María Elena Finocchiaro, Marcela Solange Villaverde
Feline mammary carcinoma (FMC) is a highly aggressive pathology that has been proposed as an interesting model of breast cancer disease, especially for the hormone refractory subgroup. Recently, cancer cell metabolism has been described as a hallmark of cancer cells. Here, we investigate the effects and mechanism of metabolic modulation by metformin (MET, anti-diabetic drug), 2-deoxyglucose (2DG, hexokinase inhibitor) or a combination of both drugs, MET/2DG on two established FMC cells lines: AlRB (HER2 (3+) and Ki67<5%) and AlRATN (HER2 (-) and Ki67>15%)...
August 3, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28796769/medication-related-patient-harm-in-new-zealand-hospitals
#9
MULTICENTER STUDY
Gillian Robb, Elizabeth Loe, Ashika Maharaj, Richard Hamblin, Mary E Seddon
AIM: The purpose of this study is to identify patterns of medication-related harm from a national perspective, and to use this information to inform decisions on where to focus medication safety efforts. This study updates a 2013 study using the same methodology. METHOD: District health boards (DHBs) still actively using either the Adverse Drug Event (ADE) Trigger Tool (TT) or the Global Trigger Tool (GTT), submitted two years of anonymised ADE data (1 July 2013-30 June 2015) to the Health Quality & Safety Commission (the Commission) using a standard template...
August 11, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28795184/domain-swelling-in-arb-type-triblock-copolymers-via-self-adjusting-effective-dispersity
#10
Sanghoon Woo, Tae Joo Shin, Youngson Choe, Heon Lee, June Huh, Joona Bang
We investigated the domain spacing of an ordered structure formed by polydisperse ARB-type triblock copolymers (triBCPs) with random middle R blocks consisting of A and B monomers. ARB-type triBCPs were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, and the dispersities of all samples were controlled as narrow as ∼1.2. From the bulk and film morphologies, it was found that the domain swelling increases as the content of middle R blocks increases, which implies that the middle R block even with a small content plays a critical role in dilating the domain spacing...
August 10, 2017: Soft Matter
https://www.readbyqxmd.com/read/28794898/a-multicenter-cohort-study-of-primary-hypertension-in-korea-study-design-and-interim-analysis-of-the-korean-registry-of-target-organ-damage-in-hypertension-korhr
#11
Suk-Won Choi, Seong Woo Han, Jong Sun Ok, Byung-Su Yoo, Mi-Seung Shin, Sung Ha Park, Kyu-Hyung Ryu
BACKGROUND: The Korean Registry of Target Organ Damage in Hypertension aims to evaluate the clinical characteristics and prevalence of subclinical target organ damage in Korean hypertensive patients. METHOD: This is a prospective, observational, multicenter cohort study in which 23 university hospitals participated. Since May 2013, we have enrolled 1,318 consecutive hypertensive patients without known cardiovascular disease who met the following inclusion criteria: 1) age older than 30 years and 2) the first visit to the participating hospitals was within the last 5 years...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28793821/the-effects-of-lcz696-in-patients-with-hypertension-compared-with-angiotensin-receptor-blockers-a-meta-analysis-of-randomized-controlled-trials
#12
Yang Zhao, Heng Yu, Xu Zhao, Ruixin Ma, Ningyin Li, Jing Yu
LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor, has been demonstrated to have greater advantages in the treatment of heart failure compared with angiotensin-converting enzyme inhibitors, enalapril, or angiotensin receptor blockers (ARBs). However, studies that compared the efficacy and safety of LCZ696 against valsartan in patients with hypertension are limited. To provide further evidence for the benefits of LCZ696 and to make this assessment, a meta-analysis of randomized controlled trials (RCTs) was performed...
September 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28792642/wastewater-pollution-differently-affects-the-antibiotic-resistance-gene-pool-and-biofilm-bacterial-communities-across-streambed-compartments
#13
Jèssica Subirats, Xavier Triadó-Margarit, Ladislav Mandaric, Vicenç Acuña, José Luis Balcázar, Sergi Sabater, Carles M Borrego
Wastewater discharges introduce antibiotic residues and antibiotic-resistant bacteria (ARB) into surface waters. Both inputs directly affect the streambed resistome, either by exerting a selective pressure that favor the proliferation of resistant phenotypes or by enriching the resident communities with wastewater-associated ARB. Here, we investigated the impact of raw and treated urban wastewater discharges on epilithic (growing on rocks) and epipsammic (growing on sandy substrata) streambed biofilms. The effects were assessed by comparing control and impact sites i) on the composition of bacterial communities; ii) on the abundance of twelve antibiotic resistance genes (ARGs) encoding resistance to β-lactams, fluoroquinolones, sulfonamides, tetracyclines, macrolides and vancomycin, as well as the class 1 integron-integrase gene (intI1); and iii) on the occurrence of wastewater-associated bacteria, including putative pathogens, and their potential linkage to target ARGs...
August 9, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28791529/effects-of-raas-inhibitors-in-patients-with-kidney-disease
#14
REVIEW
Fan Zhang, Hong Liu, Di Liu, Yexin Liu, Huiqiong Li, Xia Tan, Fuyou Liu, Youming Peng, Hongqing Zhang
Proteinuria and decline of renal function are associated with progression of kidney disease. The Renin Angiotensin Aldosterone System (RAAS) plays an important role in blood pressure regulation, fluid volume, and sodium balance. Overactivity of RAAS contributes to the pathogenesis of a variety of clinical conditions including progress of chronic kidney disease (CKD). This review summarizes the use of RAAS inhibitors as dual therapy or monotherapy in different stages of kidney disease. Experimental and clinical studies have demonstrated RAAS inhibitors prevent proteinuria, kidney fibrosis and slow decline of renal function and thus play a protective role in both early and end stages of kidney disease...
August 8, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28790052/dose-of-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-and-outcomes-in-heart-failure-a-meta-analysis
#15
Muhammad Shahzeb Khan, Gregg C Fonarow, Ali Ahmed, Stephen J Greene, Muthiah Vaduganathan, Hassan Khan, Catherine Marti, Mihai Gheorghiade, Javed Butler
BACKGROUND: The association between angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) doses on outcomes in patients with heart failure (HF) with reduced ejection fraction is uncertain. The objective of this study was to investigate the effect of dose of ACEI and ARBs on outcomes and drug discontinuation in patients with HF with reduced ejection fraction. METHODS AND RESULTS: MEDLINE, Ovid SP, and Embase were searched from the inception of these databases till August 2016...
August 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28774396/aspirin-does-not-increase-heart-failure%C3%A2-events-in-heart-failure-patients-from-the-warcef%C3%A2-trial
#16
John R Teerlink, Min Qian, Natalie A Bello, Ronald S Freudenberger, Bruce Levin, Marco R Di Tullio, Susan Graham, Douglas L Mann, Ralph L Sacco, J P Mohr, Gregory Y H Lip, Arthur J Labovitz, Seitetz C Lee, Piotr Ponikowski, Dirk J Lok, Stefan D Anker, John L P Thompson, Shunichi Homma
OBJECTIVES: The aim of this study was to determine whether aspirin increases heart failure (HF) hospitalization or death in patients with HF with reduced ejection fraction receiving an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB). BACKGROUND: Because of its cyclooxygenase inhibiting properties, aspirin has been postulated to increase HF events in patients treated with ACE inhibitors or ARBs. However, no large randomized trial has addressed the clinical relevance of this issue...
August 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28774072/fabrication-of-al-mg-al-composites-via-accumulative-roll-bonding-and-their-mechanical-properties
#17
Jinfeng Nie, Mingxing Liu, Fang Wang, Yonghao Zhao, Yusheng Li, Yang Cao, Yuntian Zhu
Al(1060)/Mg(AZ31)/Al(1060) multilayered composite was successfully produced using an accumulative roll bonding (ARB) process for up to four cycles at an elevated temperature (400 °C). The microstructure evolution of the composites and the bonding characteristics at the interfaces between Al and Mg layers with increasing ARB cycles were characterized through optical microscopy, field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). It was found that the grains of Al and Mg layers were significantly refined and Al₃Mg₂ and Al12 Mg17 intermetallic compound layers formed at the Al/Mg bonding interfaces...
November 23, 2016: Materials
https://www.readbyqxmd.com/read/28772467/microstructure-evolution-and-mechanical-properties-of-al-tib%C3%A2-tic-in-situ-aluminum-based-composites-during-accumulative-roll-bonding-arb-process
#18
Jinfeng Nie, Fang Wang, Yusheng Li, Yang Cao, Xiangfa Liu, Yonghao Zhao, Yuntian Zhu
In this study, a kind of Al-TiB₂/TiC in situ composite was successfully prepared using the melt reaction method and the accumulative roll-bonding (ARB) technique. The microstructure evolution of the composites with different deformation treatments was characterized using field emission scanning electron microscopy (FESEM) and a transmission electron microscope (TEM). The mechanical properties of the Al-TiB₂/TiC in situ composite were also studied with tensile and microhardness tests. It was found that the distribution of reinforcement particles becomes more homogenous with an increasing ARB cycle...
January 25, 2017: Materials
https://www.readbyqxmd.com/read/28770426/the-benefit-of-angiotensin-at1-receptor-blockers-for-early-treatment-of-hypertensive-patients
#19
REVIEW
Bruno Trimarco, Ciro Santoro, Marco Pepe, Maurizio Galderisi
ESC guidelines for management of arterial hypertension allow one to choose among five classes of antihypertensive drugs indiscriminately. They are based on the principle that in the management of hypertensive patients, it is fundamental to reduce blood pressure (BP), independently of the utilized drug. However, it has been demonstrated that the renin-angiotensin system (RAS) plays a relevant role in the hypertensive-derived development and progression of organ damage. Thus, antihypertensive drugs interfering with the RAS should be preferred in preventing and reducing target organ damage...
August 2, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28767167/the-impact-of-age-and-sex-on-the-reporting-of-cough-and-angioedema-with-ras-inhibitors-a-case-non-case-study-in-vigibase
#20
Fawaz F Alharbi, Anzhelika A V Kholod, Patrick C Souverein, Ronald H Meyboom, Mark C H de Groot, Anthonius de Boer, Olaf H Klungel
The purpose of this study was to assess the impact of age and sex on the reporting of cough and angioedema related to renin angiotensin system (RAS) inhibitors. A case/non-case study was performed in VigiBase. Two case groups were identified, reports of cough and reports of angioedema and non-cases were all reports of all other adverse events. Logistic regression analysis was used to assess the association between reporting of cough and angioedema with each class of RAS inhibitors stratified by age/sex and to control for confounding...
August 2, 2017: Fundamental & Clinical Pharmacology
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