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https://www.readbyqxmd.com/read/28633885/characteristics-of-paraspinal-muscle-spindle-response-to-mechanically-assisted-spinal-manipulation-a-preliminary-report
#1
William R Reed, Joel G Pickar, Randall S Sozio, Michael A K Liebschner, Joshua W Little, Maruti R Gudavalli
OBJECTIVES: The purpose of this preliminary study is to determine muscle spindle response characteristics related to the use of 2 solenoid powered clinical mechanically assisted manipulation (MAM) devices. METHODS: L6 muscle spindle afferents with receptive fields in paraspinal muscles were isolated in 6 cats. Neural recordings were made during L7 MAM thrusts using the Activator V (Activator Methods Int. Ltd., Phoenix, AZ) and/or Pulstar (Sense Technology Inc., Pittsburgh, PA) devices at their 3 lowest force settings...
June 17, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28605582/assessing-antibiotic-permeability-of-gram-negative-bacteria-via-nanofluidics
#2
SoonGweon Hong, Tobias J Moritz, Christopher M Rath, Pramila Tamrakar, Philip Lee, Thomas Krucker, Luke P Lee
While antibiotic resistance is increasing rapidly, drug discovery has proven to be extremely difficult. Antibiotic resistance transforms some bacterial infections into deadly medical conditions. A significant challenge in antibiotic discovery is designing potent molecules that enter Gram-negative bacteria and also avoid active efflux mechanisms. Critical analysis in rational drug design has been hindered by the lack of effective analytical tools to analyze the bacterial membrane permeability of small molecules...
June 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28598485/an-open-framework-manganese-ii-phosphite-and-its-composite-membranes-with-polyvinylidene-fluoride-exhibiting-intrinsic-water-assisted-proton-conductance
#3
Mei Wang, Hong-Bin Luo, Jin Zhang, Shao-Xian Liu, Chen Xue, Yang Zou, Xiao-Ming Ren
Proton conducting materials have important technological applications as key components in electrochemical devices, including fuel cells, electrochemical sensors, electrochemical reactors and electrochromic displays. And the exploration of novel proton conducting materials is significant for the development of efficient electrochemical devices. In this study, we have investigated the proton conductance of an open-framework manganese(ii) phosphite, (NH4)0.59(H3O)1.41Mn5(HPO3)6 (1). The open-framework manganese(ii) phosphate shows superior water-stability and excellent thermal stability...
June 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28589931/inhomogeneous-spatial-distribution-of-the-magnetic-transition-in-an-iron-rhodium-thin-film
#4
C Gatel, B Warot-Fonrose, N Biziere, L A Rodríguez, D Reyes, R Cours, M Castiella, M J Casanove
Monitoring a magnetic state using thermal or electrical activation is mandatory for the development of new magnetic devices, for instance in heat or electrically assisted magnetic recording or room-temperature memory resistor. Compounds such as FeRh, which undergoes a magnetic transition from an antiferromagnetic state to a ferromagnetic state around 100 °C, are thus highly desirable. However, the mechanisms involved in the transition are still under debate. Here we use in situ heating and cooling electron holography to quantitatively map at the nanometre scale the magnetization of a cross-sectional FeRh thin film through the antiferromagnetic-ferromagnetic transition...
June 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/28589334/are-there-differences-in-gait-mechanics-in-patients-with-a-fixed-versus-mobile-bearing-total-ankle-arthroplasty-a-randomized-trial
#5
Robin M Queen, Christopher T Franck, Daniel Schmitt, Samuel B Adams
BACKGROUND: Total ankle arthroplasty (TAA) is an alternative to arthrodesis, but no randomized trial has examined whether a fixed bearing or mobile bearing implant provides improved gait mechanics. QUESTIONS/PURPOSES: We wished to determine if fixed- or mobile-bearing TAA results in a larger improvement in pain scores and gait mechanics from before surgery to 1 year after surgery, and to quantify differences in outcomes using statistical analysis and report the standardized effect sizes for such comparisons...
June 6, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28586917/toward-the-virtual-benchmarking-of-pneumatic-ventricular-assist-devices-application-of-a-novel-fluid-structure-interaction-based-strategy-to-the-penn-state-12-cc-device
#6
Alessandro Caimi, Francesco Sturla, Bryan Good, Marco Vidotto, Rachele De Ponti, Filippo Piatti, Keefe B Manning, Alberto Redaelli
The pediatric use of pneumatic ventricular assist devices (VADs) as a bridge to heart transplant still suffers for short-term major complications such as bleeding and thromboembolism. Although numerical techniques are increasingly exploited to support the process of device optimization, an effective virtual benchmark is still lacking. Focusing on the 12 cc Penn State pneumatic VAD, we developed a novel fluid-structure interaction (FSI) model able to capture the device functioning, reproducing the mechanical interplay between the diaphragm, the blood chamber, and the pneumatic actuation...
August 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28586149/comparative-analysis-of-von-willebrand-factor-profiles-after-implantation-of-left-ventricular-assist-device-and-total-artificial-heart
#7
H J Reich, J Morgan, F Arabia, L Czer, J Moriguchi, D Ramzy, F Esmailian, L Lam, J Dunhill, O Volod
BACKGROUND: Bleeding remains a challenge during mechanical circulatory support and underlying mechanisms are incompletely understood. Functional von Willebrand Factor (VWF) impairment due to loss of high molecular weight multimers (MWM) produces acquired von Willebrand Disease (VWD) after left ventricular assist device (LVAD). Little is known about VWF multimers with total artificial hearts (TAHs). Here, VWF profiles with LVADs and TAHs are compared using a VWD panel. METHODS: VWD evaluations for patients with LVAD or TAH (2013-14) were retrospectively analyzed and included: VWF activity (Ristocetin Cofactor, VWF:RCo), VWF antigen (VWF:Ag), ratio of VWF:RCo to VWF:Ag, and quantitative VWF multimeric analysis...
June 6, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28573663/suppression-of-charge-density-wave-state-in-two-dimensional-1t-tise2-by-atmospheric-oxidation
#8
Lifei Sun, Chuanhui Chen, Qinghua Zhang, Christian Sohrt, Tianqi Zhao, Guanchen Xu, Jinghui Wang, Dong Wang, Kai Rossnagel, Lin Gu, Chenggang Tao, Liying Jiao
Two-dimensional (2D) metallic transition metal dichalcogenides (TMDCs), such as 1T-TiSe2, have recently emerged as unique platforms for exploring their exciting properties of superconductivity and charge density wave (CDW). Here we observe that 2D 1T-TiSe2 undergoes rapid oxidation under ambient condition, significantly affecting its CDW phase transition behaviors. We comprehensively investigate the oxidation process of 2D TiSe2 by tracking the evolution of the chemical composition and atomic structure with various microscopic and spectroscopic techniques and reveal its unique selenium-assisting oxidation mechanism...
June 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28568969/clinical-significance-of-anti-hla-antibodies-associated-with-ventricular-assist-device-use-in-pediatric-patients-a-united-network-for-organ-sharing-database-analysis
#9
H Sonali Magdo, Kurt R Schumacher, Sunkyung Yu, Robert J Gajarski, Joshua M Friedland-Little
While VAD use in pediatric patients has previously been associated with anti-HLA antibody production, the clinical significance of these antibodies is unclear. We investigated the clinical impact of anti-HLA antibodies associated with VAD use in a large cohort of pediatric HTx recipients. From 2004 to 2011, pediatric cardiomyopathy patients post-HTx (N=1288) with pre-HTx PRA levels were identified from the United Network for Organ Sharing database. PRA levels were compared between VAD patients and those with no history of MCS...
June 1, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28567581/temporary-biventricular-support-with-extracorporeal-membrane-oxygenation-a-feasible-therapeutic-approach-for-cardiogenic-shock-with-multiple-organ-failure
#10
Osamu Seguchi, Tomoyuki Fujita, Takuya Watanabe, Kensuke Kuroda, Eriko Hisamatsu, Seiko Nakajima, Takuma Sato, Haruki Sunami, Masanobu Yanase, Hiroki Hata, Junjiro Kobayashi, Takeshi Nakatani, Norihide Fukushima
Various strategies using a ventricular assist device (VAD) are applied to rescue Interagency Registry for Mechanically Assisted Circulatory Support profile 1 (Profile-1) patients. However, the optimal use of VAD in Profile-1 patients has not been completely elucidated. We retrospectively reviewed 23 Profile-1 patients [mean age 36.9 ± 16.6 years, 14 males; 11 with non-ischemic cardiomyopathy (NICM), 9 with fulminant myocarditis (FM), 2 with ischemic cardiomyopathy (ICM), and 1 with peripartum cardiomyopathy (PPCM); 18 with pre-operative percutaneous extracorporeal membrane oxygenation (p-ECMO) support] who underwent VAD implantation from 2011 to 2015 at our institution...
May 31, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28562669/design-and-preliminary-analysis-of-a-vaginal-inserter-for-speculum-free-cervical-cancer-screening
#11
Mercy Nyamewaa Asiedu, Júlia Agudogo, Marlee S Krieger, Robert Miros, Rae Jean Proeschold-Bell, John W Schmitt, Nimmi Ramanujam
OBJECTIVE: Cervical cancer screening usually requires use of a speculum to provide a clear view of the cervix. The speculum is one potential barrier to screening due to fear of pain, discomfort and embarrassment. The aim of this paper is to present and demonstrate the feasibility of a tampon-sized inserter and the POCkeT Colposcope, a miniature pen sized-colposcope, for comfortable, speculum-free and potentially self-colposcopy. STUDY DESIGN: We explored different designs using 3D computer-aided design (CAD) software and performed mechanical testing simulations on each...
2017: PloS One
https://www.readbyqxmd.com/read/28555015/simple-technique-of-exfoliation-and-dispersion-of-multilayer-graphene-from-natural-graphite-by-ozone-assisted-sonication
#12
Zaw Lin, Paneer Selvam Karthik, Masaki Hada, Takeshi Nishikawa, Yasuhiko Hayashi
Owing to its unique properties, graphene has attracted tremendous attention in many research fields. There is a great space to develop graphene synthesis techniques by an efficient and environmentally friendly approach. In this paper, we report a facile method to synthesize well-dispersed multilayer graphene (MLG) without using any chemical reagents or organic solvents. This was achieved by the ozone-assisted sonication of the natural graphite in a water medium. The frequency or number of ozone treatments plays an important role for the dispersion in the process...
May 27, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28546755/pediatric-ventricular-assist-devices-current-challenges-and-future-prospects
#13
REVIEW
Sarah Burki, Iki Adachi
The field of mechanical circulatory support has made great strides in the preceding 2 decades. Although pediatric mechanical circulatory support has lagged behind that of adults, the gap between them is expected to close soon. The only device currently approved by the US Food and Drug Administration for use in children is the Berlin Heart EXCOR ventricular assist device (VAD). The prospective Berlin Heart Investigational Device Exemption Trial demonstrated good outcomes, such as bridge to transplantation or recovery, in ~90% of children supported with this device...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28544632/understanding-the-limiting-factors-of-solvent-annealed-small-molecule-bulk-heterojunction-organic-solar-cells-from-a-chemical-perspective
#14
Aurelien Viterisi, Daniel Fernandez, Vijay Kumar Challuri, James William Ryan, Eugenia Martinez-Ferrero, Francesc Guispert-Guirado, Marta Martinez, Eduardo Escudero, Caterina Stenta, Lluis Francisco Marsal, Emilio Palomares
A detailed account on the limiting factors of solvent annealed bulk-heterojunction small molecule organic solars cell is given. This account is based on the extensive characterization of solar cell devices made from a library of five diketopyrolopyrole (DPP) donor dyes. Their chemical structure is designed in such a way as to provide insights on the energetics of solar cell active layer microstructure formation. Numerous chemical and physical properties of the active layers are assessed and interrelated such as light absorption, molecular packing in the solid state, crystal-forming properties in thin films, charge carrier mobility and charge carrier recombination kinetics...
May 24, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28543813/inhaled-pulmonary-vasodilator-therapy-for-management-of-right-ventricular-dysfunction-after-left-ventricular-assist-device-placement-and-cardiac-transplantation
#15
Leah A Sabato, David M Salerno, Jeremy D Moretz, Douglas L Jennings
Right ventricular failure (RVF) after cardiac transplant (CTX) or implantation of a continuous-flow left ventricular assist device (CF-LVAD) is associated with significant post-operative morbidity and mortality. A variety of modalities have been used to treat post-operative RVF, including management of volume status, intravenous inotropes and vasodilators, and right-sided mechanical support. Inhaled vasodilator agents are a unique treatment option aimed at minimizing systemic absorption by delivering therapy directly to the pulmonary vasculature...
May 24, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28543744/repetitive-supra-physiological-shear-stress-impairs-red-blood-cell-deformability-and-induces-hemolysis
#16
Jarod T Horobin, Surendran Sabapathy, Michael J Simmonds
The supra-physiological shear stress that blood is exposed to while traversing mechanical circulatory assist devices affects the physical properties of red blood cells (RBCs), impairs RBC deformability, and may induce hemolysis. Previous studies exploring RBC damage following exposure to supra-physiological shear stress have employed durations exceeding clinical instrumentation, thus we explored changes in RBC deformability following exposure to shear stress below the reported "hemolytic threshold" using shear exposure durations per minute (i...
May 23, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28543331/integration-of-optical-applicator-with-balloon-catheter-for-photothermal-treatment-of-biliary-stricture
#17
Jinoh Bak, Jieun Hwang, Suhyun Park, Hyun W Kang
BACKGROUND AND OBJECTIVE: Bile duct stricture is an uncommon disease in gastroenterology resulting from postoperative trauma. In spite of non-surgical treatments, clinical outcomes for the biliary strictures still encounter high restenosis and stent migration. The objective of the current study was to investigate the feasible application of a balloon catheter-integrated diffing applicator to thermally treat the bile duct stricture. MATERIALS AND METHODS: 400-μm optical fibers were micro-machined and then integrated with an inflatable balloon catheter...
May 25, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28540366/recombination-in-perovskite-solar-cells-significance-of-grain-boundaries-interface-traps-and-defect-ions
#18
Tejas S Sherkar, Cristina Momblona, Lidón Gil-Escrig, Jorge Ávila, Michele Sessolo, Henk J Bolink, L Jan Anton Koster
Trap-assisted recombination, despite being lower as compared with traditional inorganic solar cells, is still the dominant recombination mechanism in perovskite solar cells (PSCs) and limits their efficiency. We investigate the attributes of the primary trap-assisted recombination channels (grain boundaries and interfaces) and their correlation to defect ions in PSCs. We achieve this by using a validated device model to fit the simulations to the experimental data of efficient vacuum-deposited p-i-n and n-i-p CH3NH3PbI3 solar cells, including the light intensity dependence of the open-circuit voltage and fill factor...
May 12, 2017: ACS Energy Letters
https://www.readbyqxmd.com/read/28533303/cardiopulmonary-resuscitation-in-adults-and-children-with-mechanical-circulatory-support-a-scientific-statement-from-the-american-heart-association
#19
REVIEW
Mary Ann Peberdy, Jason A Gluck, Joseph P Ornato, Christian A Bermudez, Russell E Griffin, Vigneshwar Kasirajan, Richard E Kerber, Eldrin F Lewis, Mark S Link, Corinne Miller, Jeffrey J Teuteberg, Ravi Thiagarajan, Robert M Weiss, Brian O'Neil
Cardiac arrest in patients on mechanical support is a new phenomenon brought about by the increased use of this therapy in patients with end-stage heart failure. This American Heart Association scientific statement highlights the recognition and treatment of cardiovascular collapse or cardiopulmonary arrest in an adult or pediatric patient who has a ventricular assist device or total artificial heart. Specific, expert consensus recommendations are provided for the role of external chest compressions in such patients...
May 22, 2017: Circulation
https://www.readbyqxmd.com/read/28532425/combined-pulmonary-and-left-ventricular-support-with-veno-pulmonary-ecmo-and-impella-5-0-for-cardiogenic-shock-after-coronary-surgery
#20
Sameh Sayed, Christoph Schimmer, Ina Shade, Rainer Leyh, Ivan Aleksic
BACKGROUND: Mechanical circulatory support is a common practice nowadays in the management of patients after cardiogenic shock due to myocardial infarction. The single or combined use of one or more devices for mechanical support depends not only on the advantage or disadvantage of these devices but also on the timing of use of these devices before the development of multi organ failure. In our case we used more than one tool for mechanical circulatory support during the prolonged and complicated course of our patient with postcardiotomy cardiogenic shock after coronary artery bypass surgery...
May 22, 2017: Journal of Cardiothoracic Surgery
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