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https://www.readbyqxmd.com/read/29045281/pharmacokinetics-of-amikacin-in-critical-care-patients-on-extracorporeal-device
#1
Jesus Ruiz-Ramos, Ricardo Gimeno, Francisca Pérez, Paula Ramirez, Esther Villarreal, Monica Gordon, Carlos Vicent, María Remedios Marqués, Álvaro Castellanos-Ortega
In this study, we evaluate the effect of extracorporeal membrane oxygenation (ECMO) and ventricular assist devices (Levitronix) on the pharmacokinetic of amikacin in critically ill patients. Twelve patients with ECMO and three with Levitronix devices who started treatment with amikacin were included. Amikacin pre (Cmax) and post (Cmin) dose serum concentrations were measured during the first 72-96 hours of treatment initiation. Pharmacokinetic parameters were performed by Bayesian adjustment. The median initial dose was 1,000 mg (range: 600-1,400 mg)...
October 18, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29045177/outcomes-of-endovascular-management-of-late-vascular-hemorrhage-after-pancreatic-transplant
#2
Shamar J Young, Lindsey Bergren, Ty Dunn, Prashant Shrestha, Kunal Yadav, Nicholas Frank, Raja Kandaswamy, Jafar Golzarian
OBJECTIVE: The aim of this retrospective study is to evaluate the endovascular treatment of hemorrhage in the nonperioperative setting in pancreas transplant recipients. MATERIALS AND METHODS: All angiograms performed between January 1, 1999, and June 1, 2016, to treat hemorrhage after pancreatic transplant at a single large-volume transplant center were reviewed. Fourteen patients who underwent 21 angiograms were identified. The patients' charts were reviewed for clinical indications, technical aspects of the endovascular interventions, outcomes, and complications...
October 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29044529/automated-identification-of-normoblast-cell-from-human-peripheral-blood-smear-images
#3
Dev Kumar DAS, Asok Kumar Maiti, Chandan Chakraborty
In this paper, we have presented a new computer-aided technique for automatic detection of nucleated red blood cells (NRBCs) or normoblast cell from peripheral blood smear image. The proposed methodology initiates with the localization of the nucleated cells by adopting multilevel thresholding approach in smear images. A novel colour space transformation technique has been introduced to differentiate nucleated blood cells [white blood cells (WBCs) and NRBC] from red blood cells (RBCs) by enhancing the contrast between them...
October 17, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/29043649/genome-wide-quantitative-fitness-analysis-qfa-of-yeast-cultures
#4
Eva-Maria Holstein, Conor Lawless, Peter Banks, David Lydall
We provide a detailed protocol for robot-assisted, genome-wide measurement of fitness in the model yeast Saccharomyces cerevisiae using Quantitative Fitness Analysis (QFA). We first describe how we construct thousands of double or triple mutant yeast strains in parallel using Synthetic Genetic Array (SGA) procedures. Strains are inoculated onto solid agar surfaces by liquid spotting followed by repeated photography of agar plates. Growth curves are constructed and the fitness of each strain is estimated. Robot-assisted QFA, can be used to identify genetic interactions and chemical sensitivity/resistance in genome-wide experiments, but QFA can also be used in smaller scale, manual workflows...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29043542/undergraduate-basic-surgical-skills-education-impact-on-attitudes-to-a-career-in-surgery-and-surgical-skills-acquisition
#5
P F McAnena, N O'Halloran, B M Moloney, D Courtney, R M Waldron, G Flaherty, M J Kerin
INTRODUCTION: Basic surgical skills modules in medical education are effective in teaching skills and increasing confidence among students approaching surgery. However, these modules are not delivered universally and their effect on the professional development of graduates has not been established. We aimed to assess the impact of a 10-week basic surgical skills module on attitudes and technical skills of first year medical students compared to interns. METHODS: Eighteen students participated and were assessed using a 4-part questionnaire...
October 17, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29043356/cationic-amphiphilic-zn-porphyrin-with-high-antifungal-photodynamic-potency
#6
Sara Moghnie, Artak Tovmasyan, James Craik, Ines Batinic-Haberle, Ludmil Benov
Photodynamic therapy (PDT) is a promising alternative approach particularly attractive for treatment of localized fungal infections. It is based on compounds, photosensitizers (PSs), which when excited with visible light, generate reactive species that ultimately cause cell death. Such species have short lifespans; as a consequence, efficiency and selectivity of the PDT treatment depend mainly on the properties of the PSs. This study is the first to explore the effect of cationic porphyrin-based photosensitizers on Saccharomyces cerevisiae, a member of the fungus kingdom...
October 18, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29042300/pregnancy-related-low-back-pain-in-women-in-turkey-prevalence-and-risk-factors
#7
Savas Sencan, Emel Ece Ozcan-Eksi, Isa Cuce, Selcuk Guzel, Baki Erdem
OBJECTIVES: To investigate the prevalence of pregnancy-related low back pain (PRLBP) in women in Turkey, identify the factors associated with PRLBP and predict the risk of PRLBP. MATERIALS AND METHODS: This cross-sectional study included a total of 1500 pregnant women admitted to a prenatal care clinic in a secondary care hospital in Turkey between August 2011 and September 2014. All participants were asked to complete a survey questionnaire. The pregnant women who reported recurrent or continuous pain in the lumbar spine or pelvis for more than 1 week were offered a clinical examination for PRLBP by the spine physiatrist...
October 14, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29041947/the-fear-reduction-exercised-early-free-approach-to-low-back-pain-study-protocol-for-a-randomised-controlled-trial
#8
Ben Darlow, James Stanley, Sarah Dean, J Haxby Abbott, Sue Garrett, Fiona Mathieson, Anthony Dowell
BACKGROUND: Low back pain (LBP) is a major health issue associated with considerable health loss and societal costs. General practitioners (GPs) play an important role in the management of LBP; however, GP care has not been shown to be the most cost-effective approach unless exercise and behavioural counselling are added to usual care. The Fear Reduction Exercised Early (FREE) approach to LBP has been developed to assist GPs to manage LBP by empowering exploration and management of psychosocial barriers to recovery and provision of evidence-based care and information...
October 17, 2017: Trials
https://www.readbyqxmd.com/read/29041901/prevalence-of-drug-resistant-pulmonary-tuberculosis-in-india-systematic-review-and-meta-analysis
#9
Vishal Goyal, Vijay Kadam, Prashant Narang, Vikram Singh
BACKGROUND: Drug-resistant pulmonary tuberculosis (DR-TB) is a significant public health issue that considerably deters the ongoing TB control efforts in India. The purpose of this review was to investigate the prevalence of DR-TB and understand the regional variation in resistance pattern across India from 1995 to 2015, based on a large body of published epidemiological studies. METHODS: A systematic review of published studies reporting prevalence of DR-TB from biomedical databases (PubMed and IndMed) was conducted...
October 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29041783/the-lived-experiences-and-social-support-needs-of-first-time-mothers-at-health-care-facilities-in-the-city-of-tshwane-south-africa
#10
Mmajapi E T Masala-Chokwe, Tendani S Ramukumba
BACKGROUND: Social support refers to the assistance people receive from others, and it is divided into four types of support. Given the increasing mortality and morbidity rates of mothers and neonates postpartum, this study intended to determine whether the social support needs of the first-time mothers were met after early discharge from health care facilities. OBJECTIVES: The objective of the study was to explore the lived experiences and social support needs of the first-time mothers after an early discharge from health care facilities in the City of Tshwane, Gauteng...
September 22, 2017: Curationis
https://www.readbyqxmd.com/read/29041034/inhaled-versus-systemic-corticosteroids-for-preventing-bronchopulmonary-dysplasia-in-ventilated-very-low-birth-weight-preterm-neonates
#11
REVIEW
Sachin S Shah, Arne Ohlsson, Henry L Halliday, Vibhuti S Shah
BACKGROUND: Bronchopulmonary dysplasia (BPD) remains an important cause of mortality and morbidity in preterm infants and inflammation plays a significant role in its pathogenesis. The use of inhaled corticosteroids may modulate the inflammatory process without concomitant high systemic steroid concentrations and less risk of adverse effects. This is an update of a review published in 2012 (Shah 2012). We recently updated the related review on "Inhaled versus systemic corticosteroids for treating bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates"...
October 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29040609/improving-patient-safety-and-efficiency-of-medication-reconciliation-through-the-development-and-adoption-of-a-computer-assisted-tool-with-automated-electronic-integration-of-population-based-community-drug-data-the-rightrx-project
#12
Robyn Tamblyn, Nancy Winslade, Todd C Lee, Aude Motulsky, Ari Meguerditchian, Melissa Bustillo, Sarah Elsayed, David L Buckeridge, Isabelle Couture, Christina J Qian, Teresa Moraga, Allen Huang
Background and Objective: Many countries require hospitals to implement medication reconciliation for accreditation, but the process is resource-intensive, thus adherence is poor. We report on the impact of prepopulating and aligning community and hospital drug lists with data from population-based and hospital-based drug information systems to reduce workload and enhance adoption and use of an e-medication reconciliation application, RightRx. Methods: The prototype e-medical reconciliation web-based software was developed for a cluster-randomized trial at the McGill University Health Centre...
October 11, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29040498/genome-stability-of-bovine-in-vivo-conceived-cleavage-stage-embryos-is-higher-compared-to-invitro-produced-embryos
#13
Olga Tšuiko, Maaike Catteeuw, Masoud Zamani Esteki, Aspasia Destouni, Osvaldo Bogado Pascottini, Urban Besenfelder, Vitezslav Havlicek, Katrien Smits, Ants Kurg, Andres Salumets, Thomas D'Hooghe, Thierry Voet, Ann Van Soom, Joris Robert Vermeesch
STUDY QUESTION: Is the rate and nature of chromosome instability (CIN) similar between bovine in vivo-derived and in vitro-cultured cleavage-stage embryos? SUMMARY ANSWER: There is a major difference regarding chromosome stability of in vivo-derived and in vitro-cultured embryos, as CIN is significantly lower in in vivo-derived cleavage-stage embryos compared to in vitro-cultured embryos. WHAT IS KNOWN ALREADY: CIN is common during in vitro embryogenesis and is associated with early embryonic loss in humans, but the stability of in vivo-conceived cleavage-stage embryos remains largely unknown...
September 23, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29039893/open-radical-prostatectomy-reproducing-robot-assisted-radical-prostatectomy-involving-antegrade-nerve-sparing-and-continuous-anastomosis
#14
Se Yun Kwon, Jun Nyung Lee, Yun-Sok Ha, Seock Hwan Choi, Tae-Hwan Kim, Tae Gyun Kwon
PURPOSE: To present modified RRP using the same method as RALP and compare its surgical outcomes with RALP. MATERIALS AND METHODS: Demographics, perioperative and functional outcomes of the 322 patients that underwent RRP (N=99) or RALP (N=223) at our institution from January 2011 through June 2013 were evaluated retrospectively. Postoperative incontinence and erectile dysfunction are involved functional outcomes. During the modified procedure, the bladder neck was dissected first as for RALP...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29039889/robot-assisted-single-port-radical-nephrectomy-and-cholecystectomy-description-and-technical-aspects
#15
Francisco Hidelbrando Alves Mota Filho, Luis Felipe Sávio, Rafael Eiji Sakata, Renato Fidelis Ivanovic, Marco Antonio Nunes da Silva, Ronaldo Maia, Carlo Passerotti
INTRODUCTION: Robot-Assisted Single Site Radical Nephrectomy (RASS-RN) has been reported by surgeons in Europe and United States (1-3). To our best knowledge this video presents the first RASS-RN with concomitant cholecystectomy performed in Latin America. CASE: A 66 year-old renal transplant male due to chronic renal failure presented with an incidental 1.3cm nodule in the upper pole of the right kidney. In addition, symptomatic gallbladder stones were detected...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29039356/strain-modulation-assisted-enhanced-broadband-photodetector-based-on-large-area-flexible-few-layered-gr-mos2-on-cellulose-paper
#16
Parikshit Sahatiya, Sushmee Badhulika
Electronic structure and carrier behavior in semiconductor junctions can be effectively modulated on the application of strain. This work represents the first demonstration of a large-area, flexible, paper-based graphene-molybdenum disulfide (Gr/MoS2) broadband photodetector using a low-cost solution-processed hydrothermal method and enhancement in photodetection through strain modulation by assembling the device on polydimethylsiloxane. Optimization, in terms of process parameters, was carried out to obtain trilayer MoS2 over Gr-cellulose paper...
October 17, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29039100/analysis-of-complement-activation-by-nanoparticles
#17
Barry W Neun, Anna N Ilinskaya, Marina A Dobrovolskaia
The complement system is a group of proteins, which function in plasma to assist the innate immunity in rapid clearance of pathogens. The complement system also contributes to coordination of the adaptive immune response. Complement Activation Related Pseudo Allergy or CARPA is a life-threatening condition commonly reported with certain types of drugs and nanotechnology-based combination products. While CARPA symptoms are similar to that of anaphylaxis, the mechanism behind this pathology does not involve IgE and is mediated by the complement system...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29038830/a-distance-blended-learning-program-to-upgrade-the-clinical-competence-of-district-non-doctor-anesthesia-providers-in-nepal
#18
Shristi Shah, Stephen Knoble, Oliver Ross, Stephen Pickering
BACKGROUND: Across Nepal, anesthesia at a district level is provided mostly by non-doctor anesthesia providers (anesthesia assistants-AAs). Nepal's Government recognized the need to sustain competence with continuous professional development and to upgrade 6-month trained working AAs to professional equivalence with the new national standard of 12-month training. As they are essential district health workers and AA clinical training sites are full, an innovative distance blended learning, competency-based, upgrade 1-year course was developed and conducted in 2014-2017 for two batches...
October 16, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29038568/impact-of-coulomb-correlations-on-magnetic-anisotropy-in-mn3ga-ferrimagnet
#19
Srijan Kumar Saha, Zhen Liu, Gargi Dutta
Traditional density functional theory (DFT) miserably fails to reproduce the experimental volume and magnetic anisotropy of D022 Mn3Ga, which has recently become one of the most sought-after materials in order to achieve a stable spin switching at low current density. Despite great progress over the last 10 years, this issue has hitherto remained unsolved. Here, taking into account the effects of strong electronic correlations beyond what is included in standard DFT, we show by comparison with the experiment that the DFT+U method is capable of quantitatively describing the volume and the magnetic anisotropy energy (MAE) in this alloy with physically meaningful choice of onsite Coulomb-U parameter...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037445/effect-of-age-and-renal-function-on-survival-after-left-ventricular-assist-device-implantation
#20
Rahatullah Muslem, Kadir Caliskan, Sakir Akin, Yunus E Yasar, Kavita Sharma, Nisha A Gilotra, Isabella Kardys, Brian Houston, Glenn Whitman, Ryan J Tedford, Dennis A Hesselink, Ad J J C Bogers, Olivier C Manintveld, Stuart D Russell
Left ventricular assist devices (LVAD) are increasingly used, especially as destination therapy in in older patients. The aim of this study was to evaluate the effect of age on renal function and mortality in the first year after implantation. A retrospective multicenter cohort study was conducted, evaluating all LVAD patients implanted in the 2 participating centers (age ≥18 years). Patients were stratified according to the age groups <45, 45-54, 55-64, and ≥65 years old. Overall, 241 patients were included (mean age 52...
September 20, 2017: American Journal of Cardiology
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