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https://www.readbyqxmd.com/read/29161618/bayesian-synthesis-for-simulation-based-generation-of-probability-of-detection-pod-curves
#1
Mohamed Subair Syed Akbar Ali, Anish Kumar, Purnachandra B Rao, Jayakumar Tammana, Krishnan Balasubramaniam, Prabhu Rajagopal
This paper examines the feasibility of using Bayesian synthesis to reduce the number of experimental cases and trials required for generation of probability of detection (PoD) curves. A Bayesian framework is developed for the data-level combination of experimental and simulated datasets, in the context of the inspection of back-wall breaking notches in metallic samples by bulk ultrasonic shear waves. PoD curves generated using the proposed approach, where results from a reduced number of experimental defect cases and trials are used in combination with simulated datasets, are shown to compare well with those from the conventional approach using a large number of experiments...
November 4, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29161538/analysis-of-crash-proportion-by-vehicle-type-at-traffic-analysis-zone-level-a-mixed-fractional-split-multinomial-logit-modeling-approach-with-spatial-effects
#2
Jaeyoung Lee, Shamsunnahar Yasmin, Naveen Eluru, Mohamed Abdel-Aty, Qing Cai
In traffic safety literature, crash frequency variables are analyzed using univariate count models or multivariate count models. In this study, we propose an alternative approach to modeling multiple crash frequency dependent variables. Instead of modeling the frequency of crashes we propose to analyze the proportion of crashes by vehicle type. A flexible mixed multinomial logit fractional split model is employed for analyzing the proportions of crashes by vehicle type at the macro-level. In this model, the proportion allocated to an alternative is probabilistically determined based on the alternative propensity as well as the propensity of all other alternatives...
November 18, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29161233/swimming-but-not-vitamin-e-ameliorates-prothrombotic-state-and-hypofibrinolysis-in-a-rat-model-of-nonalcoholic-fatty-liver-disease
#3
Hussein F Sakr, Amr M Abbas, Mohamed A Haidara
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is associated with a systemic procoagulant hypofibrinolysis state that is considered as a risk factor for microangiopathy and peripheral vascular diseases. Swimming exercise ameliorates the metabolic dysfunction in type 2 diabetes. Vitamin E is a natural antioxidant that reduces the risk of endothelial dysfunction in metabolic syndrome. The aim of the present study is to investigate the effect of combined swimming exercise with vitamin E on coagulation as well as blood fibrinolysis markers in rats with NAFLD...
November 21, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29161116/corticosteroid-therapy-for-critically-ill-patients-with-the-middle-east-respiratory-syndrome
#4
Yaseen M Arabi, Yasser Mandourah, Fahad Al-Hameed, Anees A Sindi, Ghaleb A Al Mekhlafi, Mohamed A Hussein, Jesna Jose, Ruxandra Pinto, Awad Al-Omari, Ayman Kharaba, Abdullah Almotairi, Kasim Al Khatib, Basem Alraddadi, Sarah Shalhoub, Ahmed Abdulmomen, Ismael Qushmaq, Ahmed Mady, Othman Solaiman, Abdulsalam M Al-Aithan, Rajaa Al-Raddadi, Ahmed Ragab, Hanan H Balkhy, Abdulrahman Al Harthy, Ahmad M Deeb, Hanan Al Mutairi, Abdulaziz Al-Dawood, Laura Merson, Frederick G Hayden, Robert A Fowler
RATIONALE: Corticosteroid therapy is commonly used among critically ill patients with the Middle East Respiratory Syndrome (MERS), but its impact on outcomes is uncertain. Analyses of observational studies often do not account for patients' clinical condition at the time of corticosteroid therapy initiation. OBJECTIVES: To investigate the association of corticosteroid therapy on mortality and on MERS coronavirus RNA clearance in critically ill patients with MERS...
November 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29161022/structural-and-functional-studies-of-the-daunorubicin-priming-ketosynthase-dpsc
#5
David R Jackson, Gaurav Shakya, Avinash B Patel, Lina Y Mohammed, Kostas Vasilakis, Pakorn Wattana-Amorn, Timothy R Valentic, Jacob Milligan, Matthew P Crump, John Crosby, Shiou-Chuan Tsai
Daunorubicin is a type II polyketide, one of a large class of polyaromatic natural products with anticancer, antibiotic and antiviral activity. Type II polyketides are formed by the assembly of malonyl-CoA building blocks, though in rare cases, biosynthesis is initiated by the incorporation of a non-malonyl derived starter unit, which adds molecular diversity to the poly-β-ketone backbone. Priming mechanisms for the transfer of novel starter units onto polyketide synthases (PKS) are still poorly understood...
November 21, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29160135/short-term-histopathological-effects-of-dienogest-therapy-on-ovarian-endometriomas-in-vivo-nonrandomized-controlled-trial
#6
Mohamed Mabrouk, Roberto Paradisi, Alessandro Arena, Simona Del Forno, Carlotta Matteucci, Letizia Zannoni, Giacomo Caprara, Renato Seracchioli
Ovarian endometriosis is a common gynecological disorder. To date, progestins are recommended as the first-line medical treatment for symptomatic ovarian endometriosis. The aim of this study was to evaluate the main histopathological effects of short-term dienogest therapy in patients with ovarian endometriomas scheduled for surgery. A prospective, nonrandomized controlled trial, including 70 symptomatic women with single ovarian endometriotic cyst (diameter between 30-50 mm) was conducted. Women scheduled for surgery were divided into two groups, depending on the treatment established at enrollment: 36 women received progestin therapy with dienogest (P group) and 34 women received no therapy (C group)...
November 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29160107/editorial-comment-on-end-2017-0241-ra-r2
#7
Mohammed Shahait, Timothy D Averch
N/A.
November 21, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29159878/arsenobetaine-an-ecophysiologically-important-organoarsenical-confers-cytoprotection-against-osmotic-stress-and-growth-temperature-extremes
#8
Tamara Hoffmann, Bianca Warmbold, Sander H J Smits, Britta Tschapek, Stefanie Ronzheimer, Abdallah Bashir, Chiliang Chen, Anne Rolbetzki, Marco Pittelkow, Mohamed Jebbar, Andreas Seubert, Lutz Schmitt, Erhard Bremer
Arsenic, a highly cytotoxic and cancerogenic metalloid, is brought into the biosphere through geochemical sources and anthropogenic activities. A global biogeochemical arsenic biotransformation cycle exists in which inorganic arsenic species are transformed into organoarsenicals, which are subsequently mineralized again into inorganic arsenic compounds. Microorganisms contribute to this biotransformation process greatly and one of the organoarsenicals synthesized and degraded in this cycle is arsenobetaine...
November 21, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29159811/a-deep-learning-method-for-classifying-mammographic-breast-density-categories
#9
Aly A Mohamed, Wendie A Berg, Hong Peng, Yahong Luo, Rachel C Jankowitz, Shandong Wu
PURPOSE: Mammographic breast density is an established risk marker for breast cancer and is visually assessed by radiologists in routine mammogram image reading, using four qualitative Breast Imaging and Reporting Data System (BI-RADS) breast density categories. It is particularly difficult for radiologists to consistently distinguish the two most common and most variably assigned BI-RADS categories, i.e., "scattered density" and "heterogeneously dense". The aim of this work was to investigate a deep learning-based breast density classifier to consistently distinguish these two categories, aiming at providing a potential computerized tool to assist radiologists in assigning a BI-RADS category in current clinical workflow...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159721/design-synthesis-in-silico-and-in-vitro-antimicrobial-screenings-of-novel-1-2-4-triazoles-carrying-1-2-3-triazole-scaffold-with-lipophilic-side-chain-tether
#10
Mohamed Reda Aouad, Mariem Mohammed Mayaba, Arshi Naqvi, Sanaa K Bardaweel, Fawzia Faleh Al-Blewi, Mouslim Messali, Nadjet Rezki
BACKGROUND: 1,2,4-Triazoles and 1,2,3-triazoles have gained significant importance in medicinal chemistry. RESULTS: This study describes a green, efficient and quick solvent free click synthesis of new 1,2,3-triazole-4,5-diesters carrying a lipophilic side chain via 1,3-dipolar cycloaddition of diethylacetylene dicarboxylate with different surfactant azides. Further structural modifications of the resulting 1,2,3-triazole diesters to their corresponding 1,2,4-triazole-3-thiones via multi-step synthesis has been also investigated...
November 21, 2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/29159702/evaluation-of-levels-sources-and-health-hazards-of-road-dust-associated-toxic-metals-in-jalalabad-and-kabul-cities-afghanistan
#11
Waqar Azeem Jadoon, Wahdatullah Khpalwak, Russel Chrispine Garven Chidya, Sherif Mohamed Mohamed Ali Abdel-Dayem, Kazuhiko Takeda, Masood Arshad Makhdoom, Hiroshi Sakugawa
This study was designed to investigate selected road-dust associated heavy metals, their relations with natural and anthropogenic sources, and potential human and environmental health risks. For this purpose, 42 and 36 road-dusts samples were collected from Jalalabad and Kabul cities (Afghanistan), respectively. The following elements were found in descending concentrations: Mn, Zn, Pb, Ni, Cu, Cr, Co, and Cd in Jalalabad; and Mn, Zn, Ni, Cu, Cr, Pb, Co, and Cd in Kabul. Except for Ni, all the elemental contents were less than the Canadian permissible limits in residential/parkland soils...
November 20, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29159693/betahistine-dihydrochloride-transdermal-delivery-via-optimized-thermosensitive-gels-percutaneous-absorption-evaluation-using-rat-growth-as-a-biomarker
#12
Mohammed Hassan Elkomy, Shahira F El-Menshawe, Adel Ahmed Ali, Abdelkhalik Ali Halawa, Ahmed S G Srag El-Din
The aim of this study was to develop and optimize a betahistine dihydrochloride (BH) thermoreversible bioadhesive gel intended for transdermal delivery. The gels were obtained via cold method. A full factorial design was employed to investigate the joint effect of Poloxamer 407 concentration (18 and 20%), adhesive polymer type (Polyvinyl pyrolidone, Hydroxypropyl methylcellulose, and Carbopol 934), and adhesive polymer concentration (0.5 and 1.5%) on gelling temperature, viscosity at 37 °C, and adhesion strength...
November 20, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29159673/double-bundle-anterior-cruciate-ligament-reconstruction-is-better-than-single-bundle-reconstruction-in-terms-of-objective-assessment-but-not-in-terms-of-subjective-score
#13
Faisal Ahmed Hashem El-Sherief, Wael Abdelkarim Aldahshan, Yaser Elsayed Wahd, Ashraf Mohamed Abdelaziz, Hany Abdel Gawwad Soliman, Tohamy Goda Hassan, Hassan Fathy Elbehairy, Adel Hamed Awadallah
PURPOSE: A comparison of clinical outcomes between double-bundle (DB) and single-bundle (SB) anterior cruciate ligament (ACL) reconstruction for patients with ACL injury. METHODS: Sixty patients were treated with either SB (n = 30) or DB (n = 30) ACL reconstruction between 2011 and 2012. The hamstring tendons were autografted with suspensory fixation on the femoral side, while a bio-absorbable interference screw was used for fixation on the tibial side. These patients were evaluated using Lysholm score, International Knee Documentation Committee (IKDC) forms (both objective and subjective), Lachman test, pivot shift test, and KT 1000 arthrometer...
November 20, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29159667/uterus-sparing-vaginolaparoscopic-sacrocolpopexy-for-apical-pelvic-organ-prolapse
#14
Atef Darwish, Mostafa Bahlol, AbdelGhafar Ahmad, Mohamed Fekry
INTRODUCTION AND HYPOTHESIS: Our aim was to evaluate the safety, feasibility, and effectiveness of a vaginolaparoscopic sacrocolpopexy (VLS) technique for treating apical pelvic organ prolapse (POP). MATERIALS AND METHODS: This was a prospective interventional case series (design classification: Canadian Task Force II3) performed in the endoscopic unit of a tertiary care referral facility and university hospital. We assessed 15 symptomatic parous women with stage ≥2 apical POP according to the POP Quantification (POP-Q) classification...
November 20, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/29159577/core-curriculum-case-illustration-a-rare-case-of-an-isolated-fallopian-tube-torsion
#15
Nehal Mohamed Ibrahim Saloum, Hayley Wurtz Hunt, Shaimaa Abdelhassib Fadl
This is the 46th installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at: http://www.erad.org/page/CCIP_TOC .
November 21, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/29159483/obestatin-can-potentially-differentiate-wharton-s-jelly-mesenchymal-stem-cells-into-insulin-producing-cells
#16
Rana K El-Asfar, Mohamed M Kamal, Rania S Abd El-Razek, Ebtehal El-Demerdash, Hala O El-Mesallamy
In vitro-generation of β-cells from Wharton's jelly mesenchymal stem cells (WJ-MSCs) could provide a potential basis for diabetes mellitus cell therapy. However, the generation of functional insulin-producing cells (IPCs) from WJ-MSCs remains a challenge. Recently, obestatin, a gut hormone, was found to promote β-cell generation from pancreatic precursor cells. Accordingly, we hypothesize that obestatin can induce the differentiation of WJ-MSCs into IPCs. Therefore, the purpose of the current study is to examine the ability of obestatin to generate IPCs in comparison to well-known extrinsic factors that are commonly used in IPCs differentiation protocols from MSCs, namely exendin-4 and glucagon-like peptide-1 (GLP-1)...
November 20, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29159244/clinical-pathological-and-molecular-data-concerning-coenurus-cerebralis-in-sheep-in-egypt
#17
Said Amer, Ahmed ElKhatam, Yasuhiro Fukuda, Lamia I Bakr, Shereif Zidan, Ahmed Elsify, Mostafa A Mohamed, Chika Tada, Yutaka Nakai
This article contains information related to a recent study "Prevalence and Identity of Taenia multiceps cysts "Coenurus cerebralis" in Sheep in Egypt" (Amer et al., 2017) [1]. Specifically, affected sheep showed neurological disorders manifested as depression, head shaking and circling, altered head position, incoordination and paralysis in some cases. Brain-derived cysts were molecularly identified by PCR-sequence analysis at mitochondrial 12S rRNA gene marker. Cyst-induced pathological changes included degenerative changes and demyelination in brain tissue, infiltration of lymphocytes and histiocytes...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29159137/optimum-efficiency-of-treatment-plants-discharging-wastewater-into-river-case-study-tigris-river-within-the-baghdad-city-in-iraq
#18
Tariq J Al-Musawi, Ibrahim A Mohammed, Huda M Atiea
The present study aims to manage and determine the most economical efficiency of five wastewater treatment plants discharging wastewater into the Tigris River in Iraq. The management system was based on ensuring the five-day biological oxygen demand concentration in the river is <30 mg/L according to the Iraqi standards. In many cases, the determined optimized efficiencies were found to be lower than the present working efficiencies. Although this was good for the environment, it was not cost-effective...
2017: MethodsX
https://www.readbyqxmd.com/read/29158964/ginsenoside-rk1-bioactivity-a-systematic-review
#19
Abdelrahman Elshafay, Ngo Xuan Tinh, Samar Salman, Yara Saber Shaheen, Eman Bashir Othman, Mohamed Tamer Elhady, Aswin Ratna Kansakar, Linh Tran, Le Van, Kenji Hirayama, Nguyen Tien Huy
Ginsenoside Rk1 (G-Rk1) is a unique component created by processing the ginseng plant (mainly Sung Ginseng (SG)) at high temperatures. The aim of our study was to systematically review the pharmacological effects of G-Rk1. We utilized and manually searched eight databases to select in vivo and in vitro original studies that provided information about biological, pharmaceutical effects of G-Rk1 and were published up to July 2017 with no restriction on language or study design. Out of the 156 papers identified, we retrieved 28 eligible papers in the first skimming phase of research...
2017: PeerJ
https://www.readbyqxmd.com/read/29158858/elastofibroma-dorsi-case-report-and-review-of-the-literature
#20
Basma Karrakchou, Youssef Yaikoubi, Mohamed Said Chairi, Abdelouahed Jalil
Elastofibroma dorsi (ED) is an uncommon benign soft tissue tumor with an uncertain pathogenesis. It mostly occurs in the infrascapular region of elderly people with a female predominance. Typically bilateral, ED can also be unilateral. While many patients remain asymptomatic, ED can be responsible of a periscapular arch source of ache. The diagnosis of ED is set on magnetic resonance imaging, and the pathological study ensures the diagnosis after surgical excision and establishes the differential diagnosis with malignant neoplasic process...
2017: Pan African Medical Journal
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