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https://www.readbyqxmd.com/read/28433825/a-distributed-framework-for-health-information-exchange-using-smartphone-technologies
#1
Mohamed Abdulnabi, Ahmed Al-Haiqi, Mlm Kiah, A A Zaidan, B B Zaidan, Muzammil Hussein
Nationwide health information exchange (NHIE) continues to be a persistent concern for government agencies, despite the many efforts and the conceived benefits of sharing patient data among healthcare providers. Difficulties in ensuring global connectivity, interoperability, and concerns on security have always hampered the government from successfully deploying NHIE. By looking at NHIE from a fresh perspective and bearing in mind the pervasiveness and power of modern mobile platforms, this paper proposes a new approach to NHIE that builds on the notion of consumer-mediated HIE, albeit without the focus on central health record banks...
April 19, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28433166/chitosan-graphene-oxide-films-and-co2-dried-porous-aerogel-microspheres-interfacial-interplay-and-stability
#2
Sana Frindy, Ana Primo, Hamid Ennajih, Abou El Kacem Qaiss, Rachid Bouhfid, Mohamed Lahcini, El Mokhtar Essassi, Hermenegildo Garcia, Abdelkrim El Kadib
The intimate interplay of chitosan (CS) and graphene oxide (GO) in aqueous acidic solution has been explored to design upon casting, nanostructured "brick-and-mortar" films (CS-GO-f) and by acidic-to-basic pH inversion, porous CO2-dried aerogel microspheres (CS-GO-m). Owing to the presence of oxygenated functional groups in GO, good-quality crack-free hybrid films were obtained. Mechanical properties were improved independently of the GO content and it was found that a 20wt% loading affords hybrid film characterized with a Young modulus three times superior to that reached with the same loading of layered clay...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433014/phase-behavior-of-supported-lipid-bilayers-a-systematic-study-by-coarse-grained-molecular-dynamics-simulations
#3
Asma Poursoroush, Maria Maddalena Sperotto, Mohamed Laradji
Solid-supported lipid bilayers are utilized by experimental scientists as models for biological membranes because of their stability. However, compared to free standing bilayers, their close proximity to the substrate may affect their phase behavior. As this is still poorly understood, and few computational studies have been performed on such systems thus far, here we present the results from a systematic study based on molecular dynamics simulations of an implicit-solvent model for solid-supported lipid bilayers with varying lipid-substrate interactions...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28432923/triterpenoid-saponins-from-the-roots-of-spergularia-marginata
#4
David Pertuit, Mustafa Larshini, Malika Aitsidi Brahim, Mohamed Markouk, Anne-Claire Mitaine-Offer, Thomas Paululat, Stéphanie Delemasure, Patrick Dutartre, Marie-Aleth Lacaille-Dubois
Phytochemical investigations of the roots of Spergularia marginata had led to the isolation of four previously undescribed triterpenoid saponins, a known one and one spinasterol glycoside. Their structures were established by extensive NMR and mass spectroscopic techniques as 3-O-β-D-glucuronopyranosyl echinocystic acid 28-O-α-L-arabinopyranosyl-(1 → 2)-α-L-rhamnopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)-α-L- arabinopyranosyl ester, 3-O-β-D-glucopyranosyl-(1 → 3)-β-D-glucuronopyranosyl echinocystic acid 28-O-α-L-arabinopyranosyl-(1 → 2)-α-L-rhamnopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)- α-L-arabinopyranosyl ester, 3-O-β-D-glucopyranosyl-(1 → 4)-3-O-sulfate-β-D-glucuronopyranosyl echinocystic acid 28-O-α-L-arabinopyranosyl-(1 → 2)-α-L-rhamnopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyl ester, and 3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucuronopyranosyl 21-O-acetyl acacic acid...
April 19, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28432554/epigallocatechin-gallate-protects-beas-2b-cells-from-lipopolysaccharide-induced-apoptosis-through-upregulation-of-gastrin-releasing-peptide
#5
Peethambaran Divya, Bijesh Puthusseri, Denny Joseph Kollareth Manual, Mohammed Azharuddin Savanur
Gastrin-releasing peptide (GRP) plays a major role in the development and maintenance of lung epithelial cells by promoting cell division, whereas its suppression causes growth arrest and apoptosis. The present study shows that human bronchial epithelial BEAS-2B cells challenged with lipopolysaccharide (LPS), an endotoxin from gram-negative bacteria, downregulated GRP expression and induced apoptosis via upregulation of p53 and active caspase-3, signifying the importance of GRP in lung epithelial cell survival...
April 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28432426/posterior-cranial-fossa-tumours-in-children-at-national-cancer-institute-sudan-a-single-institution-experience
#6
Moawia Mohammed Ali Elhassan, Haytham Hussein Mohammed Osman, Jeannette Parkes
BACKGROUND: Posterior cranial fossa tumours (PCF) comprise 54-70% of childhood brain tumours. The clinical profile and outcomes of these tumours differ in area of the world. The aim of this study is to describe clinical characteristics, treatment and outcome of posterior cranial fossa tumours in Sudan. MATERIAL AND METHODS: A retrospective study of children diagnosed with posterior cranial fossa tumours and treated between January 1998 and December 2015 at National Cancer Institute, Sudan...
April 21, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28432387/yttrium-90-radioembolization-for-unresectable-combined-hepatocellular-cholangiocarcinoma
#7
Lauren S Chan, Daniel Y Sze, George A Poultsides, John D Louie, Mohammed A Abdelrazek Mohammed, David S Wang
PURPOSE: Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare mixed cell type primary liver cancer with limited data to guide management. Transarterial radioembolization with yttrium-90 microspheres (RE) is an emerging treatment option for both hepatocellular carcinoma and intrahepatic cholangiocarcinoma. This study explored the safety and efficacy of RE for unresectable cHCC-CC. METHODS: Patients with histopathologically confirmed cHCC-CC treated with RE were retrospectively evaluated...
April 21, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28432344/aptamer-based-label-free-electrochemical-biosensor-array-for-the-detection-of-total-and-glycated-hemoglobin-in-human-whole-blood
#8
Shimaa Eissa, Mohammed Zourob
The increase of the level of glucose in blood leads to an increase in the fraction of glycated hemoglobin (HbA1c). Therefore, the percentage of HbA1c in the blood can serve as a marker for the average glucose level over the past three months and thus, it can be used to diagnose diabetes. Here, we report the selection, identification and characterization of specific DNA aptamers against HbA1c- and total hemoglobin (tHb) and their integration into an electrochemical array sensing platform. High affinity and specificity aptamers were selected in vitro showing dissociation constants of 2...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431992/genomic-answers-for-recurrent-spontaneous-abortion-in-saudi-arabia-an-array-comparative-genomic-hybridization-approach
#9
Sajjad Karim, Hasan Salleh Jamal, Abdullraheem Rouzi, Mohammed Salleh M Ardawi, Hans-Juergen Schulten, Zeenat Mirza, Nuha A Alansari, Maha M Al-Quaiti, Heba Abusamra, Muhammad Imran Naseer, Rola Turki, Adeel Gulzar Chaudhary, Mamdooh Gari, Adel Mohammed Abuzenadah, Mohammed Hussain Al-Qhatani
To study the genomics/genetic factors associated with recurrent spontaneous abortion (RSA), as ∼50% of RSA are unexplained. However, chromosome abnormalities have been reported to play major role in RSA. We performed whole genome array-CGH based genomic analysis of forty four Saudi RSA patients to identify potential molecular and chromosomal abnormalities. We identified a total of 845 alterations, usually not detected by classic cytogenetic methods, in different genomic regions using a cut off value of -0...
April 18, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28431978/temporal-niche-switching-in-arabian-oryx-oryx-leucoryx-seasonal-plasticity-of-24h-activity-patterns-in-a-large-desert-mammal
#10
Joshua G Davimes, Abdulaziz N Alagaili, Mads F Bertelsen, Osama B Mohammed, Jason Hemingway, Nigel C Bennett, Paul R Manger, Nadine Gravett
The Arabian oryx, a moderately large mammal that inhabits a harsh desert environment, has been shown to exhibit seasonal variations in activity and inactivity patterns. Here we analyzed the continuous year-round activity patterns of twelve free-roaming Arabian oryx under natural conditions from two varying desert environments in Saudi Arabia using abdominally implanted activity meters. We simultaneously recorded weather parameters at both sites to determine whether environmental factors are responsible for temporal niche switching as well as the seasonal structuring and timing of this behavioural plasticity...
April 18, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28431894/molecular-cloning-and-functional-characterization-of-duck-nucleotide-binding-oligomerization-domain-1-nod1
#11
Huilin Li, Hui Jin, Yaqian Li, Dejian Liu, Mohamed Frahat Foda, Yunbo Jiang, Rui Luo
Nucleotide-binding oligomerization domain 1 (NOD1) is an imperative cytoplasmic pattern recognition receptor (PRR) and considered as a key member of the NOD-like receptor (NLR) family which plays a critical role in innate immunity through sensing microbial components derived from bacterial peptidoglycan. In the current study, the full-length of duck NOD1 (duNOD1) cDNA from duck embryo fibroblasts (DEFs) was cloned. Multiple sequence alignment and phylogenetic analysis demonstrated that duNOD1 exhibited a strong evolutionary relationship with chicken and rock pigeon NOD1...
April 18, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28431882/-primary-carcinoma-of-seminal-vesicle-a-delayed-revealed-cancer
#12
Mohamed Fourati, Hela Fourati, Ibrahim Mejdoub, Rebai Nouri, Mohamed Nabil M'hiri
No abstract text is available yet for this article.
April 18, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28431875/protein-oxidation-and-autoantibodies-reactivity-against-malondialdehyde-and-hydrogen-peroxide-modified-thyroid-antigens-in-plasma-of-patients-with-graves-disease-and-hashimoto-thyroiditis
#13
Malek Mseddi, Riadh Ben Mansour, Bochra Gargouri, Fatma Mnif, Samir El Ghawi, Boutheina Hammami, Abdelmonem Ghorbel, Mohamed Abid, Saloua Lassoued
The aim of this study was first to investigate the oxidative proteins modifications in the plasma of both autoimmune thyroid diseases (AITD), Graves' disease (GD) and Hashimoto Thyroiditis (HT). Then, the impact of these oxidative modifications on immune response was evaluated by measuring the reactivity of patients' autoantibodies against malondialdéhyde (MDA) and Hydrogen peroxide (H2O2) modified thyroid antigens (T.Ag) in comparison to native ones. Carbonyl and thiol groups, and MDA-protein adducts were first assessed among 74 AITD patients and 65 healthy controls...
April 18, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28431481/arab-dentists-refusal-to-treat-hiv-positive-patients-a-survey-of-recently-graduated-dentists-from-three-arab-dental-schools
#14
Arheiam Arheiam, Maha El Tantawi, Asim Al-Ansari, Mohamed Ingafou, Asma El-Howiti, Kamis Gaballah, Wafaa AbdelAziz
OBJECTIVE: To assess intended refusal of recent graduates from three Arab dental schools to treat HIV + patients and factors associated with this intention. MATERIALS AND METHODS: In 2015, convenience samples of recent dental graduates were included from Libya, Egypt and the United Arab Emirates. Participants responded to a questionnaire assessing personal background, knowledge of oral manifestations and fluids transmitting HIV, perceived adequacy of training and self-efficacy to manage blood exposures, attitude to risk of infection, moral beliefs and willingness to treat HIV + patients...
April 21, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28431312/melatonin-charge-transfer-complex-with-2-3-dichloro-5-6-dicyano-1-4-benzoquinone-molecular-structure-dft-studies-thermal-analyses-evaluation-of-biological-activity-and-utility-for-determination-of-melatonin-in-pure-and-dosage-forms
#15
Gehad G Mohamed, Maher M Hamed, Nadia G Zaki, Mohamed M Abdou, Marwa El-Badry Mohamed, Abanoub Mosaad Abdallah
A simple, accurate and fast spectrophotometric method for the quantitative determination of melatonin (ML) drug in its pure and pharmaceutical forms was developed based on the formation of its charge transfer complex with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as an electron acceptor. The different conditions for this method were optimized accurately. The Lambert-Beer's law was found to be valid over the concentration range of 4-100μgmL(-1) ML. The solid form of the CT complex was structurally characterized by means of different spectral methods...
April 4, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28431194/closed-form-equation-to-estimate-the-dielectric-properties-of-biological-tissues-as-a-function-of-age
#16
Beadaa Mohammed, Konstanty Bialkowski, Amin Abbosh, Paul C Mills, Andrew P Bradley
Developing microwave systems for biomedical applications requires accurate dielectric properties of biological tissues for reliable modeling before prototyping and subject testing. Dielectric properties of tissues decrease with age due to the change in their water content, but there are no detailed age-dependent data, especially for young tissue-like newborns, in the literature. In this article, an age-dependent formula to predict the dielectric properties of biological tissues was derived. In the proposed method, the variation of water concentration in each type of tissue as a function of age was used to calculate its relative permittivity and conductivity...
April 21, 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28431104/the-potential-overlapping-populations-for-treatment-with-belimumab-and-rituximab-using-current-nhs-england-and-national-institute-for-health-and-care-excellence
#17
Eoghan M McCarthy, Emily Sutton, Stephanie Nesbit, Ben Parker, David Jayne, Bridget Griffiths, David A Isenberg, Anisur Rahman, Caroline Gordon, David P D'Cruz, Benjamin Rhodes, Peter Lanyon, Edward M Vital, Chee-Seng Yee, Christopher J Edwards, Lee-Suan Teh, Mohammed Akil, Neil J McHugh, Asad Zoma, Ian N Bruce
No abstract text is available yet for this article.
April 18, 2017: Rheumatology
https://www.readbyqxmd.com/read/28430998/reply-to-mohamed-s-a-mohamed
#18
Anders S I Andreasson, John H Dark, Andrew J Fisher
No abstract text is available yet for this article.
April 19, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28430974/using-transcranial-magnetic-stimulation-of-the-undamaged-brain-to-identify-lesion-sites-that-predict-language-outcome-after-stroke
#19
Diego L Lorca-Puls, Andrea Gajardo-Vidal, Mohamed L Seghier, Alexander P Leff, Varun Sethi, Susan Prejawa, Thomas M H Hope, Joseph T Devlin, Cathy J Price
Transcranial magnetic stimulation focused on either the left anterior supramarginal gyrus or opercular part of the left inferior frontal gyrus has been reported to transiently impair the ability to perform phonological more than semantic tasks. Here we tested whether phonological processing abilities were also impaired following lesions to these regions in right-handed, English speaking adults, who were investigated at least 1 year after a left-hemisphere stroke. When our regions of interest were limited to 0...
April 18, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28430900/ex-vivo-lung-perfusion-this-idea-deserves-testing
#20
Mohamed S A Mohamed
No abstract text is available yet for this article.
April 19, 2017: European Journal of Cardio-thoracic Surgery
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