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https://www.readbyqxmd.com/read/29707390/comparison-of-efficacy-and-ocular-surface-disease-index-score-between-bimatoprost-latanoprost-travoprost-and-tafluprost-in-glaucoma-patients
#1
Wissam Georges El Hajj Moussa, Rebecca Georges Farhat, Joseph Claud Nehme, Marwan Antoun Sahyoun, Alexandre Raymond Schakal, Alexandre Edmond Jalkh, Mariana Pierre Abi Karam, Georges Georges Azar
Aim: The purpose of this study is to evaluate and compare the efficacy of 4 prostaglandin analogues (PGAs) and to determine the incidence of ocular surface disease in newly diagnosed, primary open-angle glaucoma (POAG) patients started on one of those 4 PGAs: bimatoprost (benzalkonium chloride, BAK, 0.3 mg/mL), latanoprost (BAK 0.2 mg/mL), travoprost (polyquad), and tafluprost (BAK-free). Patients and Methods: In this single-center, open-label trial, 32 patients newly diagnosed with POAG were randomly started on one of the four PGAs...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29665040/discovery-characterization-and-clinical-utility-of-prostaglandin-agonists-for-the-treatment-of-glaucoma
#2
REVIEW
Peter G Klimko, Najam A Sharif
Topical ophthalmic formulations of analogs of the endogenous arachidonic acid cyclooxygenase metabolite, prostaglandin F2α (PGF2α ), are the standard of care for treating the blinding disease glaucoma. These are the most potent and efficacious medical therapies for lowering intraocular pressure (IOP), the most important identified risk factor for disease progression. They have few side-effects and offer the convenience of once-a-day dosing. It was initially believed that endogenous PGs raised IOP and caused substantial ocular surface adverse effects...
April 17, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29610853/a-novel-selective-soluble-guanylate-cyclase-activator-mgv354-lowers-intraocular-pressure-in-preclinical-models-following-topical-ocular-dosing
#3
Ganesh Prasanna, Luciana Ferrara, Christopher Adams, Takeru Ehara, Byron Li, Louis Yang, Chuanxi Xiang, Christopher Thow Hing Ng, Sean Kim, Christopher Towler, Todd Topley, Cale McAllister, Malay Ghosh, Ronald Newton, Rebecca Stacy, Dennis S Rice, Muneto Mogi
Purpose: The nitric oxide/soluble guanylate cyclase/protein kinase G (NO/sGC/PKG) is known to be involved in the regulation of intraocular pressure (IOP) and may be dysregulated in glaucoma. The purpose is to demonstrate that the sGC activator MGV354 lowers IOP in a monkey model of glaucoma and could be considered as a possible new clinical drug candidate. Methods: Changes to cGMP were assessed in primary human trabecular meshwork (hNTM) cells and binding studies were conducted using human sGC full-length protein...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29569087/reversal-of-retinal-pigment-epithelial-detachment-after-cessation-of-topical-travoprost-therapy
#4
Venkataramana Kalikivayi, Jerry Joseph, Blessy Thankom Mathews, Rajkumar Maheswari, Satyajit Mulanjur Vadakara, Sajeev Cherian Jacob
PURPOSE: To report the rare incidence of retinal pigment epithelial detachment (RPED) followed by topical travoprost therapy and its subsequent reattachment after cessation of the drug. METHODS: A 60-year-old male presented with gradual loss of vision in both eyes and distorted images in right eye. He gave a history of visiting an ophthalmologist a week ago for a routine eye examination. His previous reports revealed best-corrected visual acuity (BCVA) of 6/6, N6 in both eyes with raised intraocular pressures...
March 22, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29557724/drug-targeted-virtual-screening-and-molecular-dynamics-of-lipu-protein-of-mycobacterium-tuberculosis-and-mycobacterium-leprae
#5
Gurkamaljit Kaur, Bharati Pandey, Arbind Grover, Naina Garewal, Abhinav Grover, Jagdeep Kaur
The lipolytic protein LipU was conserved in mycobacterium sp. including M. tuberculosis (MTB LipU) and M. leprae (MLP LipU). The MTB LipU was identified in extracellular fraction and was reported to be essential for the survival of mycobacterium. Therefore to address the problem of drug resistance in pathogen, LipU was selected as a drug target and the viability of finding out some FDA approved drugs as LipU inhibitors in both the cases was explored. Three-dimensional (3D) model structures of MTB LipU and MLP LipU were generated and stabilized through molecular dynamics (MD)...
March 30, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29505438/association-of-postoperative-topical-prostaglandin-analog-or-beta-blocker-use-and-incidence-of-pseudophakic-cystoid-macular-edema
#6
Colten Wendel, Helena Zakrzewski, Bruce Carleton, Mahyar Etminan, Frederick S Mikelberg
PURPOSE: The purpose of this article is to determine the association of postoperative topical prostaglandin analog (PGA) or topical beta-blocker use and the incidence of pseudophakic cystoid macular edema (CME). METHODS: This was a nested case-control study. All adult patients who underwent cataract surgery between January 1, 2006 and December 31, 2016 and who were enrolled in the PharMetrics Plus database were eligible for inclusion. The association between postoperative topical PGAs (bimatoprost, latanoprost, and travoprost/travoprost-z) or beta-blocker (betaxolol, levobunolol, and timolol) use and the incidence of pseudophakic CME was assessed by conditional logistic regression...
May 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29476443/prospective-evaluation-of-two-istent-%C3%A2-trabecular-stents-one-istent-supra-%C3%A2-suprachoroidal-stent-and-postoperative-prostaglandin-in-refractory-glaucoma-4-year-outcomes
#7
Jonathan S Myers, Imran Masood, Dana M Hornbeak, Jose I Belda, Gerd Auffarth, Anselm Jünemann, Jane Ellen Giamporcaro, Jose M Martinez-de-la-Casa, Iqbal Ike K Ahmed, Lilit Voskanyan, L Jay Katz
INTRODUCTION: This study evaluates long-term outcomes of two trabecular micro-bypass stents, one suprachoroidal stent, and postoperative prostaglandin in eyes with refractory open angle glaucoma (OAG). METHODS: Prospective ongoing 5-year study of 80 eligible subjects (70 with 4-year follow-up) with OAG and IOP ≥ 18 mmHg after prior trabeculectomy and while taking 1-3 glaucoma medications. Subjects received two iStent® trabecular micro-bypass stents, one iStent Supra® suprachoroidal stent, and postoperative travoprost...
March 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29401160/meibomian-gland-features-and-conjunctival-goblet-cell-density-in-glaucomatous-patients-controlled-with-prostaglandin-timolol-fixed-combinations-a-case-control-cross-sectional-study
#8
Luca Agnifili, Rodolfo Mastropasqua, Vincenzo Fasanella, Lorenza Brescia, Barbara Scatena, Francesco Oddone, Leonardo Mastropasqua
PURPOSE: To investigate, using in vivo confocal microscopy (IVCM), the Meibomian gland (MG) features and conjunctival goblet cell density (GCD) in glaucomatous patients controlled with prostaglandin/timolol fixed combinations (PTFCs). MATERIALS AND METHODS: In this cross-sectional study, 60 white patients were treated with PTFCs, 15 with latanoprost+timolol (L+T) unfixed combination, and 15 controls were enrolled. Patients underwent the Ocular Surface Disease Index questionnaire, tear film breakup time, corneal staining, Schirmer test I, and IVCM of MGs and goblet cells...
April 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29220066/periorbital-changes-associated-with-topical-prostaglandins-analogues-in-a-hispanic-population
#9
Ferdinand Rodríguez-Agramonte, Juan Carlos Jiménez, José Raúl Montes
OBJECTIVE: To describe the prevalent side effects of prostaglandin analogues (PA) in a Hispanic population and their effect on quality of life (QOL). PATIENTS AND METHODS: This is a cross-sectional study conducted in a tertiary medical facility in which patients were evaluated in a single visit. Total of 14 participants in the study, 10 women and 4 men. Ages ranged from 26-78 years old. Subjects underwent a single full Oculoplastic evaluation by two physicians; one was blinded on patient medical history and assessed for PA side effects...
December 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28887006/a-3-month-safety-and-efficacy-study-of-travoprost-0-004-ophthalmic-solution-compared-with-timolol-in-pediatric-patients-with-glaucoma-or-ocular-hypertension
#10
El Roy Dixon, Theresa Landry, Subha Venkataraman, Nancy Gustafson, Craig Salem, Yasmin Bradfield, Leyla Ali Aljasim, Robert Feldman
PURPOSE: To evaluate efficacy and safety of travoprost in pediatric patients with ocular hypertension or glaucoma and demonstrate its noninferiority to timolol. METHODS: Patients aged 2 months to <18 years with glaucoma or ocular hypertension were randomized to receive travoprost (0.004%) or timolol eye drops (0.25% for patients aged 2 months to <3 years and 0.5% for patients ≥3 years old) for 3 months in this double-masked, parallel-group study. Intraocular pressure (IOP) was measured and patients were evaluated at 2 weeks, 6 weeks, and 3 months after treatment...
September 6, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28796877/conjunctival-bacteria-flora-of-glaucoma-patients-during-long-term-administration-of-prostaglandin-analog-drops
#11
Shinichiro Ohtani, Kimiya Shimizu, Ryohei Nejima, Fumie Kagaya, Makoto Aihara, Takuya Iwasaki, Nobuyuki Shoji, Kazunori Miyata
Purpose: To investigate the effects of the long-term use of prostaglandin analogs for glaucoma treatment on the indigenous flora of the conjunctiva. Methods: Bacterial isolates were collected from the conjunctival sacs of 68 patients at Miyata Eye Hospital from February to September 2014, who had been receiving continuous monotherapy with prostaglandin analogs for glaucoma for at least 1 year. Minimum inhibitory concentrations of levofloxacin, gatifloxacin, moxifloxacin, cefmenoxime, tobramycin, chloramphenicol, and erythromycin against the isolates were measured to determine susceptibility...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28727804/effects-of-pre-surgical-administration-of-prostaglandin-analogs-on-the-outcome-of-trabeculectomy
#12
Takako Miki, Tomoko Naito, Miyuki Fujiwara, Ryoichi Araki, Rieko Kiyoi, Yusuke Shiode, Atsushi Fujiwara, Yuki Morizane, Fumio Shiraga
For primary open angle glaucoma (POAG), laser treatment or surgery is used when the target intraocular pressure (IOP) cannot be achieved by pharmacological agents, such as prostaglandin (PG) analogs; these drugs also have varied effects. We retrospectively reviewed the medical records of 74 POAG patients (74 eyes) whose IOP was inadequately controlled by PG analogs (bimatoprost [13 eyes], latanoprost [34 eyes], tafluprost [11 eyes], and travoprost [16 eyes]) and underwent primary trabeculectomy. The proportion of patients with no recurrent IOP elevation within 24 months post-trabeculectomy was significantly (P < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28716077/periorbital-changes-associated-with-prostaglandin-analogs-in-korean-patients
#13
Hee Weon Kim, Youn Joo Choi, Kyung Wha Lee, Min Joung Lee
BACKGROUND: Prostaglandin analogs (PGAs) are commonly used to treat glaucoma because of their powerful intraocular pressure lowering effect. However, various periorbital changes associated with the use of PGAs have been reported. We investigated the incidence of periorbital changes in Korean patients who were treated with PGAs, and analyzed clinical factors associated with superior sulcus deepening. METHODS: This study included 58 glaucoma patients who were treated with latanoprost, travoprost, or bimatoprost unilaterally...
July 17, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28692596/inadvertent-cyclodialysis-cleft-and-hypotony-following-ab-interno-trabeculotomy-using-the-trabectome-device-requiring-surgical-repair
#14
Thomas A Berk, Jella A An, Iqbal Ike K Ahmed
PURPOSE: To report the first case of inadvertent cyclodialysis cleft and hypotony requiring surgical repair following ab-interno trabeculotomy (AIT) using the Trabectome device, and the postoperative clinical results following direct suture cyclopexy. METHODS: A 55-year-old man with hypotonous maculopathy secondary to cyclodialysis cleft inadvertently created 3 years earlier during AIT using the Trabectome device was referred for repair. Direct suture cyclopexy was performed and topical homatropine and dexamethasone drops were prescribed postoperatively...
August 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28617732/the-effects-of-latanoprost-with-benzalkonium-chloride-versus-travoprost-with-sofzia-on-the-ocular-surface
#15
Kamran Rahmatnejad, Christopher J Rapuano, Parul Ichhpujani, Sheryl S Wizov, Marlene R Moster, Lisa A Hark, L Jay Katz
PURPOSE: To assess ocular surface changes in participants using latanoprost with benzalkonium chloride (Xalatan) and travoprost with SofZia (Travatan Z). METHODS: In this prospective, open-label, nonrandomized cohort study, participants were classified into two groups: group 1 (n=28) naive to glaucoma therapy, group 2 (n=27) on previous Xalatan monotherapy in both eyes. Both groups started (or continued) Xalatan in the right eye and Travatan Z in the left eye. Baseline, 1-, and 2-month measurements of tear breakup time (TBUT), corneal staining score, conjunctival staining score, conjunctival hyperemia score, tear production, and intraocular pressure were obtained...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28616797/the-efficacy-and-safety-of-bimatoprost-timolol-maleate-latanoprost-timolol-maleate-and-travoprost-timolol-maleate-fixed-combinations-on-24-h-iop
#16
Suzan Guven Yilmaz, Cumali Degirmenci, Yunus Emre Karakoyun, Emil Yusifov, Halil Ates
PURPOSE: To evaluate the effect of bimatoprost/timolol maleate fixed combination (BTFC), latanoprost/timolol maleate fixed combination (LTFC), and travoprost/timolol maleate fixed combination (TTFC) on 24-h intraocular pressure (IOP) in patients with open-angle glaucoma. METHODS: This prospective, observer-masked, randomized study included 50 patients with primary open-angle glaucoma. All patients were using hypotensive lipids and timolol maleate fixed combination treatment for ≥4 weeks and had an IOP ≤ 21 mmHg...
June 14, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28458346/blood-pressure-elevation-associated-with-topical-prostaglandin-f2%C3%AE-analogs-an-analysis-of-the-different-spontaneous-adverse-event-report-databases
#17
Katsuhiro Ohyama, Haruna Kawakami, Michiko Inoue
Topical prostaglandin F2α (PGF2α) analogs are widely used as the first line of therapy for glaucoma. Systemic PGF2α is suggested to increase blood pressure. Some ophthalmic formulations with β-receptor blocking or α-receptor stimulating actions are reported to cause systemic adverse events such as a decrease in heart rate and blood pressure. The objective of this study was to evaluate the association between topical PGF2α analogs and blood pressure elevation. We analyzed the reports obtained from the Food and Drug Administration Adverse Event Reporting System (FAERS) database from the first quarter of 2004 until the end of 2015 and the Japanese Adverse Drug Event Report (JADER) database from April 2004 to January 2016 for signal detection using reporting odds ratio (ROR), a method of disproportionality analyses...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28437175/pharmacokinetics-and-safety-of-travoprost-0-004-ophthalmic-solution-preserved-with-polyquad-in-pediatric-patients-with-glaucoma
#18
MULTICENTER STUDY
Erin Stahl, Dominique Bremond-Gignac, Theresa Landry, Mike Curtis, Kinfemichael Gedif, Sami Al Shahwan, El Roy Dixon
PURPOSE: To evaluate the systemic pharmacokinetics (PKs) of travoprost 0.004% preserved with Polyquad® (TRAVATAN® ) in pediatric patients with glaucoma or ocular hypertension. METHODS: This was a phase 1, open-label, multicenter clinical study of patients aged ≥2 months to <18 years. Patients received daily administration of travoprost 0.004% preserved with Polyquad in both eyes for 7 days. Plasma samples were collected 30 min before the final dose and at 10, 20, 40, and 80 min postdose...
June 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28384377/implantation-of-two-second-generation-trabecular-micro-bypass-stents-and-topical-travoprost-in-open-angle-glaucoma-not-controlled-on-two-preoperative-medications-18-month-follow-up
#19
John Berdahl, Lilit Voskanyan, Jonathan S Myers, Dana M Hornbeak, Jane Ellen Giamporcaro, L Jay Katz, Thomas W Samuelson
IMPORTANCE: Additional data are sought regarding treatment options for glaucoma, a major cause of global blindness. BACKGROUND: The study assessed outcomes following standalone implantation of two second-generation trabecular micro-bypass stents and postoperative topical prostaglandin in eyes with open-angle glaucoma not controlled on two preoperative medications. DESIGN: The study design is a prospective, nonrandomized, open-label study at a tertiary-care ophthalmology centre...
November 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28379653/factors-related-to-prostaglandin-associated-periorbitopathy-in-glaucoma-patients
#20
Chanikarn Patradul, Visanee Tantisevi, Anita Manassakorn
PURPOSE: To determine factors related to prostaglandin-associated periorbitopathy (PAP) and its prevalence in glaucoma or ocular hypertension (OHT) patients using prostaglandins analogs (PGAs). DESIGN: A cross-sectional study. METHODS: A study of glaucoma or OHT patients, using topical PGAs for at least 3 months, was performed. Eyes treated with PGAs were photoraphed and independently evaluated for PAP by 2 glaucoma specialists using at least 4 out of 7 clinical appearances...
May 2017: Asia-Pacific Journal of Ophthalmology
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