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JOURNAL ARTICLE
Anacharis Babeto de Sá-Nakanishi, Fabrício Bracht, Nair Seiko Yamamoto, Fábio Padilha, Ana Maria Kelmer-Bracht, Adelar Bracht
The chronic inflammatory state induced by cancer is expected to affect the actions of extracellular NAD(+) in the liver because these are largely mediated by eicosanoids. Under this assumption the present work was planned to investigate the influence of the Walker-256 tumor on the action of extracellular NAD(+) on metabolism and hemodynamics in the perfused rat liver. The experiments were done with livers from healthy and tumor-bearing rats with measurements of gluconeogenesis from lactate, pyruvate production, oxygen consumption and portal pressure...
June 2008: Experimental and Molecular Pathology
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