keyword
MENU ▼
Read by QxMD icon Read
search

gastric cancer cytology

keyword
https://www.readbyqxmd.com/read/29696405/gastric-washing-by-distilled-water-can-reduce-free-gastric-cancer-cells-exfoliated-into-the-stomach-lumen
#1
Atsuko Ohki, Nobutsugu Abe, Eri Yoshimoto, Yoshikazu Hashimoto, Hirohisa Takeuchi, Gen Nagao, Tadahiko Masaki, Toshiyuki Mori, Yasuo Ohkura, Masanori Sugiyama
PURPOSE: Intragastric free cancer cells in patients with gastric cancer have rarely been studied. The purpose of this study was to investigate the detection rate of intragastric free cancer cells in gastric washes using two types of solutions during endoscopic examination. We further clarified risk factors affecting the presence of exfoliated free cancer cells. METHODS: A total of 175 patients with gastric cancer were enrolled. Lactated Ringer's solution (N = 89) or distilled water (DW; N = 86) via endoscopic working channel was sprayed onto the tumor surface, and the resultant fluid was collected for cytological examination...
April 25, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29545085/synchronous-metastatic-gastric-cancer-molecular-background-and-clinical-implications-with-special-attention-to-mismatch-repair-deficiency
#2
Karol Polom, Christine Böger, Elizabeth Smyth, Daniele Marrelli, Hans-Michael Behrens, Luigi Marano, Thomas Becker, Florian Lordick, Christoph Röcken, Franco Roviello
BACKGROUND: Current guidelines recommend that metastatic gastric cancer should not be treated with surgery unless this is required for symptom control. We hypothesized that patients with mismatch repair deficiency (MMRd) gastric cancer and metastatic disease detected at the timepoint of surgical resection would have superior survival compared to patients with MMRd cancers in the same setting. METHODS: Clinicopathological details and survival data were collected from prospective databases at two large European centers on patients who had undergone surgery and were diagnosed with synchronous stage IV gastric cancer (distant lymph nodes, positive peritoneal cytology, peritoneal, and distant metastases) at the timepoint of surgery...
March 2, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29543051/use-of-serum-and-peritoneal-cea-and-ca19-9-in-prediction-of-peritoneal-dissemination-and-survival-of-gastric-adenocarcinoma-patients-are-they-prognostic-factors
#3
M Hasbahceci, F U Malya, E Kunduz, M Guler, N Unver, A Akcakaya
Introduction To evaluate the impact of serum and peritoneal levels of tumour markers on peritoneal carcinomatosis and survival in gastric adenocarcinoma. Materials and methods Patients with gastric adenocarcinoma were evaluated with regard to serum and peritoneal carcinoembryonic antigen (CEA) and CA19-9. Numeric values and groupings based on serum and peritoneal cutoff values were used. Development of peritoneal carcinomatosis, including positive washing cytology, was regarded as main outcome. Gastric cancer outcomes as disease free and overall survival were analysed...
March 15, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29536296/a-randomized-phase-ii-multicenter-trial-to-explore-efficacy-of-weekly-intraperitoneal-in-comparison-with-intravenous-paclitaxel-administered-immediately-after-gastrectomy-to-the-patients-with-high-risk-of-peritoneal-recurrence-final-results-of-the-inpact-trial
#4
Naoto Takahashi, Mitsuro Kanda, Takaki Yoshikawa, Nobuhiro Takiguchi, Kazumasa Fujitani, Katsufumi Miyamoto, Yuichi Ito, Osamu Takayama, Motohiro Imano, Norio Mitsumori, Junichi Sakamoto, Satoshi Morita, Yasuhiro Kodera
BACKGROUND: Intraperitoneal administration of paclitaxel had been considered a promising option to treat peritoneal metastasis, the most frequent pattern of recurrence in gastric cancer after D2 gastrectomy, but its safety and efficacy after gastrectomy had not been fully explored. METHODS: A phase II randomized comparison of postoperative intraperitoneal (IP) vs. intravenous (IV) paclitaxel was conducted. Patients with resectable gastric linitis plastica, cancer with minimal amount of peritoneal deposits (P1), or cancer positive for the peritoneal washing cytology (CY1) were eligible...
March 13, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29491048/gastric-cancer-cells-in-peritoneal-lavage-fluid-a-systematic-review-comparing-cytological-with-molecular-detection-for-diagnosis-of-peritoneal-metastases-and-prediction-of-peritoneal-recurrences
#5
REVIEW
Edoardo Virgilio, Enrico Giarnieri, Maria Rosaria Giovagnoli, Monica Montagnini, Antonella Proietti, Rosaria D'Urso, Paolo Mercantini, Stefano Valabrega, Genoveffa Balducci, Marco Cavallini
BACKGROUND/AIM: Detecting free tumor cells in the peritoneal lavage fluid of gastric cancer patients permits to assess a more accurate prognosis, predict peritoneal recurrence and select cases for a more aggressive treatment. Currently, cytology and molecular biology comprise the two most popular methods of detection that are under constant study by researchers. MATERIALS AND METHODS: We burrowed into the available literature comparing cytological with molecular detection of free intraperitoneal gastric cancer cells...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29438463/efficacy-and-safety-findings-from-dream-a-phase-iii-study-of-dhp107-oral-paclitaxel-versus-iv-paclitaxel-in-patients-with-advanced-gastric-cancer-after-failure-of-first-line-chemotherapy
#6
Y-K Kang, M-H Ryu, S H Park, J G Kim, J W Kim, S-H Cho, Y-L Park, S R Park, S Y Rha, M J Kang, J Y Cho, S Y Kang, S Y Roh, B-Y Ryoo, B-H Nam, Y-W Jo, K-E Yoon, S C Oh
Background: Paclitaxel is currently only available as an intravenous (IV) formulation. DHP107 is a novel oral formulation of lipid ingredients and paclitaxel. DHP107 demonstrated comparable efficacy, safety, and pharmacokinetics to IV paclitaxel as second-line therapy in patients with advanced gastric cancer (AGC). DREAM is a multicenter, open-label, prospective, randomized phase III study of patients with histologically/cytologically confirmed, unresectable/recurrent AGC after first-line therapy failure...
February 9, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29397632/conventional-cytology-vs-immunocytochemistry-of-intraoperative-peritoneal-washes-in-gastric-cancer-patients-subjected-to-gastrectomy-clinical-correlates-and-association-with-overall-survival
#7
Tomasz Olesiński, Małgorzata Malinowska, Maria Zwierko, Katarzyna Pogoda, Andrzej Rutkowski, Marek Szpakowski, Piotr Saramak, Anna Nasierowska-Guttmejer
BACKGROUND: The aim of this study was to verify if positive results yielded with conventional cytology and immunocytochemical analysis of peritoneal washes correlate with established prognostic factors and overall survival (OS) in gastric cancer patients. METHODS: The study included the data of 271 gastrectomized patients. Peritoneal washes of 131 (48.3%) patients were examined by means of conventional cytology, and material from 140 (51.7%) subjects treated surgically after this date was subjected to immunocytochemical analysis...
February 1, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29394723/-a-case-report-of-gastric-cancer-with-positive-peritoneal-lavage-cytology-and-metachronous-schnitzler-s-metastasis-treated-with-multimodality-therapy
#8
Masaru Udagawa, Yuuki Mizuno, Iichirou Ohnishi, Tetsuo Sugishita, Satoru Kakuta, Yoshiki Murase, Yuuichirou Watanabe, Rama Adikrisna
A69 -year-old male patient with type 3 gastric cancer in pyloric antrum underwent distal gastrectomy with regional lymphadenectomy. Serosal infiltration of cancer tissue was found in the anterior wall of antrum, and the evaluation of peritoneal lavage cytology were positive. Pathological analysis showed the tumor was mainly consist of moderately tubular adenocarcinoma and strongly positive for HER2 stain. Postoperatively, combined therapy of capecitabine and trastuzumab was carried out, but cisplatin was excluded because of the patient's rejection...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394645/-a-case-of-long-term-survival-of-cutaneous-metastasis-from-primary-gastric-cancer
#9
Junya Morita, Toru Aoyama, Shinya Amano, Yukio Maezawa, Sho Sawazaki, Masakatsu Numata, Tsutomu Sato, Takashi Oshima, Takanobu Yamada, Tsutomu Hayashi, Shouji Yamanaka, Norio Yukawa, Yasushi Rino, Munetaka Masuda
A 65-year-old female received distal gastrectomy for gastric cancer.The pathological diagnosis was well differentiated adenocarcinoma(tub1), type 2, pT3, ly: 1, v: 1, N0, H0, P0, M0, CY0, pStage II A.She had been observed without adjuvant chemotherapy.Five years after the resection, umbilical tumor and intraperitoneal nodules were detected by computed tomography. Needle biopsy cytology of umbilical tumor revealed metastasis from gastric cancer.Based on the diagnosis of umbilical metastasis and peritoneal dissemination, S-1(80mg/m / 2, day 1-21)and CDDP(60mg/m2, day 8)were administered for 7 courses...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394571/-long-term-complete-response-of-peritoneal-recurrence-from-advanced-gastric-cancer-using-capeox-therapy-following-radical-gastrectomy
#10
Keiji Nishibeppu, Shuhei Komatsu, Daisuke Ichikawa, Toshiyuki Kosuga, Kazuma Okamoto, Tomohiro Arita, Hirotaka Konishi, Ryo Morimura, Yasutoshi Murayama, Atsushi Shiozaki, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi, Hitoshi Fujiwara, Eigo Otsuji
Since the national insurance to use oxaliplatin(L-OHP)for gastric cancer was approved in Japan, patients with advanced or recurrent gastric cancer have been treated by CapeOX therapy as one of the standard regimens. Here, we report a case of long-term complete response of peritoneal recurrence from advanced gastric cancer using CapeOx therapy following radical gastrectomy. The patient underwent total gastrectomy with curative intent for advanced gastric cancer with cytology positive, and received S-1 based adjuvant chemotherapy for 13 months...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29331883/curative-distal-pancreatectomy-in-patients-with-acinar-cell-carcinoma-of-pancreas-diagnosed-by-endoscopic-aspiration-via-esophago-jejunostomy-a-successful-case-report
#11
Takeomi Hamada, Atsushi Nanashima, Masahide Hiyoshi, Makoto Ikenoue, Naoya Imamura, Koichi Yano, Yoshiro Fujii, Yoshimasa Kubota, Tesshin Ban, Hiroshi Kawakami, Yuichiro Sato
INTRODUCTION: This is a case report on the advances in preoperative endoscopic-guided fine-needle-aspiration (FNA) diagnosis for pancreatic carcinoma to achieve a curative operation even in patients who have a history of total gastrectomy. CASE PRESENTATION: A 65-year-old man, who underwent total gastrectomy for gastric cancer 13 years ago, had discomfort in the left lateral abdomen. A 3-cm hypovascular mass accompanying a large distal pseudocyst in the pancreatic tail was observed on computed tomography...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29321007/staging-laparoscopy-for-locally-advanced-gastric-cancer-in-chinese-patients-a-multicenter-prospective-registry-study
#12
Ziyu Li, Zhemin Li, Lianhai Zhang, Qian Liu, Zhenjun Wang, Zhongtao Zhang, Gang Xiao, Wei Fu, Xin Wang, Yingjiang Ye, Jianchun Yu, Fei Li, Lin Chen, Shibin Wang, Jiafu Ji
BACKGROUND: Staging laparoscopy(SL) is a recommended technique for the staging of Gastric Cancer(GC) and provides the indication for a radical surgery. Considering the medical practice in China, the standardized and regular usage of SL is yet to be spread. However, existing guidelines vary and make an ambiguity of indication for SL. Besides, the specific indication for Chinese patients remains a niche. This study aims to the essential, missing information of Chinese patients and tries to normalize the indication of LS in medical practice in China...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29302921/isolated-breast-metastasis-from-gastric-cancer-in-a-male-patient
#13
Hirokazu Kubo, Tetsuya Shimizu, Hitoshi Sekido, Goro Matsuda, Kazuhisa Takeda, Akira Watanabe, Risa Sakamoto, Yuji Yamamoto, Junya Toyoda, Hitoshi Niino
A 72-year-old man underwent total gastrectomy for gastric cancer (por2, T3, N2, Stage IIIA). Eleven courses of postoperative chemotherapy with TS-1 (tegafur/gimeracil/oteracil) were administered. Five months after surgery, the serum carcinoembryonic antigen value was slightly elevated. However, computed tomography did not reveal any metastatic lesions in other organs. Two years after surgery, the patient felt a mass in the left mammary. A 2-cm tumor was palpable in the central portion of the breast. Ultrasonography revealed a hypoechoic tumor, which was Class 3 on aspiration biopsy cytological examination...
April 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29277806/utility-of-nasogastric-tube-for-medical-and-surgical-oncology-of-gastric-cancer-a-prospective-institutional-study-on-a-new-and-precious-application-of-an-old-and-economic-device
#14
Edoardo Virgilio, Genoveffa Balducci, Paolo Mercantini, Enrico Giarnieri, Maria Rosaria Giovagnoli, Monica Montagnini, Antonella Proietti, Rosaria D'Urso, Marco Cavallini
BACKGROUND/AIM: Concerning gastric cancer (GC), nasogastric tube (NGT) is routinely employed for peri-operative decompression and palliative enteral nutrition. Additionally, we believe to have found a further application. PATIENTS AND METHODS: Between April 2012 and April 2017, 96 GC patients received preoperative nasogastric lavage (GL). All samples were cytologically examined to detect the presence (GL1) or absence (GL0) of malignant cells. Data were analyzed with classificatory, staging and prognostic purpose...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29204054/nuclear-heat-shock-protein-110-expression-is-associated-with-poor-prognosis-and-hyperthermo-chemotherapy-resistance-in-gastric-cancer-patients-with-peritoneal-metastasis
#15
Akiharu Kimura, Kyoichi Ogata, Bolag Altan, Takehiko Yokobori, Erito Mochiki, Mitsuhiro Yanai, Norimichi Kogure, Toru Yanoma, Masaki Suzuki, Tuya Bai, Hiroyuki Kuwano
AIM: To investigate the significance of heat shock protein 110 (HSP110) in gastric cancer (GC) patients with peritoneal metastasis undergoing hyperthermo-chemotherapy. METHODS: Primary GC patients ( n = 14) with peritoneal metastasis or positive peritoneal lavage cytology who underwent distal or total gastrectomy between April 2000 and December 2011 were enrolled in this study. The patients underwent postoperative intraperitoneal hyperthermo-chemotherapy using a Thermotron RF-8 heating device two weeks after surgery...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29183538/laparoscopic-hyperthermic-intraperitoneal-chemotherapy-for-peritoneal-carcinomatosisfrom-gastric-cancer-its-beneficial-effects-on-reduction-and-exact-evaluation-of-the-peritoneal-cancer-index
#16
Kazuyoshi Takeshita, Yang Liu, Haruaki Ishibashi, Yutaka Yonemura
We assessed whether the laparoscopic hyperthermic intraperitoneal chemotherapy (L-HIPEC) + neoadjuvant intraperitoneal and systemic chemotherapy (NIPS) could reduce the peritoneal cancer index (PCI; which is defined by Sugerbaker) and improve the possibility to obtain a complete cytoreductive surgery (CRS with peritonectomy; basically according to the Sugerbaker's procedure). After L-HIPEC + NIPS, the PCI score was decreased in 89.5 per cent of patients, and the average score was significantly reduced. The average PCI reduction of improved PCI cases was 10...
November 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29113652/examination-of-cancer-cells-exposed-to-gastric-serosa-by-serosal-stamp-cytology-plus-rt-pcr-is-useful-for-the-identification-of-gastric-cancer-patients-at-high-risk-of-peritoneal-recurrence
#17
Yuichiro Miki, Masakazu Yashiro, Kanae Ando, Tomohisa Okuno, Kishu Kitayama, Go Masuda, Tatsuro Tamura, Katsunobu Sakurai, Takahiro Toyokawa, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masahiko Osawa, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: We sought to clarify the clinical value of the examination of cancer cells exposed to gastric serosa by our novel method of serosal stamp cytology and a real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis. METHOD: A total of 70 patients who underwent gastrectomy were enrolled. Stamp cytology specimens were obtained by stamping the gastric serosa at the primary gastric tumor lesion, followed by Papanicolaou's staining...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29063636/presence-of-cancer-cells-in-gastric-lavage-of-gastric-cancer-patients-as-an-indicator-of-advanced-disease-predictor-of-tumour-aggressive-phenotype-and-independent-prognostic-factor-for-poor-survival-the-endoluminal-metastatic-pathway-of-gastric-cancer-and-gl0
#18
E Virgilio, E Giarnieri, M R Giovagnoli, M Montagnini, A Proietti, R D'Urso, G Nigri, P Mercantini, G Ramacciato, M Cavallini, G Balducci
OBJECTIVE: As of 2017, the pathobiology of gastric cancer (GC) is far from fully understood; consequently, new methods of basic and advanced research have been proposed and tested. The presence (GL1) vs absence (GL0) of malignant cells exfoliated in gastric lavage (GL) of GC patients was formerly evaluated with diagnostic intent but not for staging or prognostic assessment. We investigated this hitherto unreported application of cytopathology. METHODS: GL was preoperatively and prospectively collected from 80 GC patients and cytologically analysed...
February 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29028095/bcar4-increase-cisplatin-resistance-and-predicted-poor-survival-in-gastric-cancer-patients
#19
L Wang, Q Chunyan, Y Zhou, Q He, Y Ma, Y Ga, X Wang
OBJECTIVE: Gastric cancer is a common malignancy with increasing worldwide incidence, and chemotherapeutic drugs for gastric cancer are not effective. Long non-coding RNA (lncRNA) has been proved to be important in different cancer progression. In this research, we investigated whether lncRNAs have relations with drug resistance in gastric cancer to find new potential targets for therapy, which can increase the survival time of the drug-resistant gastric patient. PATIENTS AND METHODS: qRT-PCR was used to detect the expression of BCAR4 in 113 cases of gastric cancer tissue and adjacent tissue, and the clinical significance was also analyzed...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28890117/potential-for-peritoneal-cancer-cell-seeding-in-endoscopic-full-thickness-resection-for-early-gastric-cancer
#20
Osamu Goto, Masayuki Shimoda, Motoki Sasaki, Yoshiyuki Kiguchi, Yutaka Mitsunaga, Teppei Akimoto, Yasutoshi Ochiai, Ai Fujimoto, Tadateru Maehata, Toshihiro Nishizawa, Hiroya Takeuchi, Yuko Kitagawa, Kaori Kameyama, Naohisa Yahagi
BACKGROUND AND AIMS: During endoscopic full-thickness resection (EFTR) for cancers, whether exposure of the lumen to the abdominal cavity during the procedure is acceptable is controversial because of the potential risk of tumor cell seeding. To assess the possibility of transplantation as a result of contact with tumor cells during the procedure, we prospectively investigated the ability of cancer cells to be detached by touching the tumor surface. METHODS: In 48 patients with a single early gastric cancer resected by endoscopic submucosal dissection, stamp cytology was performed by touching the surface of the specimens to glass slides...
February 2018: Gastrointestinal Endoscopy
keyword
keyword
96068
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"