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JOURNAL ARTICLE
Hirofumi Rokutan, Yasuhito Arai, Akiko Kunita, Satoshi Yamasaki, Hiromi Nakamura, Natsuko Hama, Atsuhito Nakayama, Fumie Hosoda, Yasushi Totoki, Mitsuhiro Fujishiro, Yasuyuki Seto, Tatsuhiro Shibata, Tetsuo Ushiku
Very well-differentiated adenocarcinoma of intestinal type is a distinct subtype of gastric cancer characterized by anastomosing glands with a hand-in-hand pattern and low-grade cytologic atypia resembling intestinal metaplasia. This is a slow-growing neoplasm with an indolent clinical course; however, a subset demonstrates transformation into adenocarcinoma with higher-grade histology, typically diffuse-type carcinoma, and behaves aggressively. This study aimed to better characterize the genomic and pathologic features, with a focus on factors associated with diffuse-type transformation...
April 8, 2024: American Journal of Surgical Pathology
#2
JOURNAL ARTICLE
Sojung Kim, Han Hong Lee, Kyo Young Song, Ho Seok Seo
PURPOSE: Peritoneal washing cytology (PWC) is a widely used diagnostic tool for detecting peritoneal metastasis of advanced gastric cancer. However, the prognosis of patients with positive PWC remains poor even after gastrectomy, and treatments vary among institutions and eras. In this study, we identified the clinical factors that can help predict cytology-positive (CY(+)) gastric cancer. MATERIALS AND METHODS: We retrospectively reviewed the national data of patients with gastric cancer from 2019, as provided by the Information Committee of the Korean Gastric Cancer Association...
April 2024: Journal of Gastric Cancer
#3
JOURNAL ARTICLE
Karen van der Sluis, Niels A D Guchelaar, Lianne Triemstra, Ron H J Mathijssen, Jelle P Ruurda, Bas P L Wijnhoven, Johanna W van Sandick
BACKGROUND: Staging laparoscopy is a common diagnostic tool in gastric cancer, but its performance varies widely. The aim of this study was to gain Dutch nationwide consensus regarding the indications for and execution of staging laparoscopy in patients with gastric cancer. METHODS: All surgeons in the Netherlands specialized in gastric cancer surgery (n = 52) were asked to participate in a Delphi consensus study. The study involved an initial questionnaire with a 3-point Likert scale, an online consensus meeting, and a second questionnaire using a 2-point Likert scale (agree/disagree)...
March 19, 2024: European Journal of Surgical Oncology
#4
JOURNAL ARTICLE
Cas de Jongh, Miriam P van der Meulen, Emma C Gertsen, Hylke J F Brenkman, Johanna W van Sandick, Mark I van Berge Henegouwen, Suzanne S Gisbertz, Misha D P Luyer, Grard A P Nieuwenhuijzen, Jan J B van Lanschot, Sjoerd M Lagarde, Bas P L Wijnhoven, Wobbe O de Steur, Henk H Hartgrink, Jan H M B Stoot, Karel W E Hulsewe, Ernst Jan Spillenaar Bilgen, Marc J van Det, Ewout A Kouwenhoven, Freek Daams, Donald L van der Peet, Nicole C T van Grieken, Joos Heisterkamp, Boudewijn van Etten, Jan-Willem van den Berg, Jean-Pierre Pierie, Hasan H Eker, Annemieke Y Thijssen, Eric J T Belt, Peter van Duijvendijk, Eelco Wassenaar, Kevin P Wevers, Lieke Hol, Frank J Wessels, Nadia Haj Mohammad, Geert W J Frederix, Richard van Hillegersberg, Peter D Siersema, Erik Vegt, Jelle P Ruurda
BACKGROUND: Unnecessary D2-gastrectomy and associated costs can be prevented after detecting non-curable gastric cancer, but impact of staging on treatment costs is unclear. This study determined the cost impact of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18F FDG-PET/CT) and staging laparoscopy (SL) in gastric cancer staging. MATERIALS AND METHODS: In this cost analysis, four staging strategies were modeled in a decision tree: (1) 18F FDG-PET/CT first, then SL, (2) SL only, (3) 18F FDG-PET/CT only, and (4) neither SL nor 18F FDG-PET/CT...
March 25, 2024: Annals of Surgical Oncology
#5
REVIEW
Zexi Allan, Sasha Witts, Darren J Wong, Margaret M Lee, Jeanne Tie, Niall C Tebbutt, Nicholas J Clemons, David S Liu
PURPOSE: Gastric cancers commonly spread to the peritoneum. Its presence significantly alters patient prognosis and treatment-intent; however, current methods of peritoneal staging are inaccurate. Peritoneal tumor DNA (ptDNA) is tumor-derived DNA detectable in peritoneal lavage fluid. ptDNA positivity may indicate peritoneal micrometastasis and may be more sensitive than cytology in staging the peritoneum. In this meta-analysis, we evaluated the prognostic potential of ptDNA in gastric cancer...
March 2024: JCO Precision Oncology
#6
JOURNAL ARTICLE
Yosuke Kano, Hiroshi Ichikawa, Masaki Aizawa, Yusuke Muneoka, Kenji Usui, Takaaki Hanyu, Takashi Ishikawa, Hiroshi Yabusaki, Kazuaki Kobayashi, Shirou Kuwabara, Shigeto Makino, Yasuyuki Kawachi, Kohei Miura, Yosuke Tajima, Yoshifumi Shimada, Jun Sakata, Toshifumi Wakai
BACKGROUND: Initial chemotherapy (Initial-C) followed by surgery is a promising treatment strategy for peritoneal lavage cytology-positive gastric cancer (CY1 GC) with no other noncurative factors. The aim of this study was to investigate the survival advantage of Initial-C compared to initial surgery (Initial-S) for this disease according to the macroscopic type, which was associated with prognosis and the efficacy of chemotherapy in GC. METHODS: One hundred eighty-nine patients who were diagnosed with CY1 GC with no other noncurative factors at four institutions from January 2007 to December 2018 were enrolled...
March 21, 2024: International Journal of Clinical Oncology
#7
JOURNAL ARTICLE
B Huang, V Rampulla, M Ri, M Lindblad, M Nilsson, I Rouvelas, F Klevebro
INTRODUCTION: Gastric cancer often presents in advanced stage with a significant risk for peritoneal dissemination. Staging laparoscopy can be used to detect peritoneal carcinomatosis (PC+) and free cancer cells in peritoneal lavage cytology (CY+). The current study aimed to present the outcomes of staging laparoscopy and the prognosis of PC+ and CY+ in a Swedish high-volume center. MATERIALS AND METHODS: A cohort study including all consecutive patients with locally advanced gastric cancer who underwent staging laparoscopy between February 2008 and October 2022...
March 13, 2024: European Journal of Surgical Oncology
#8
JOURNAL ARTICLE
Zhouqiao Wu, Tingfei Gu, Changxian Xiong, Jinyao Shi, Jingpu Wang, Ting Guo, Xiaofang Xing, Fei Pang, Ning He, Rulin Miao, Fei Shan, Yuan Zhou, Ziyu Li, Jiafu Ji
OBJECTIVE: Positive peritoneal lavege cytology (CY1) gastric cancer is featured by dismal prognosis, with high risks of peritoneal metastasis. However, there is a lack of evidence on pathogenic mechanism and signature of CY1 and there is a continuous debate on CY1 therapy. Therefore, exploring the mechanism of CY1 is crucial for treatment strategies and targets for CY1 gastric cancer. METHODS: In order to figure out specific driver genes and marker genes of CY1 gastric cancer, and ultimately offer clues for potential marker and risk assessment of CY1, 17 cytology-positive gastric cancer patients and 31 matched cytology-negative gastric cancer patients were enrolled in this study...
February 29, 2024: Chinese Journal of Cancer Research
#9
JOURNAL ARTICLE
Paul H Sugarbaker, Tom Deng
BACKGROUND: Peritoneal metastases from gastrointestinal or gynecologic malignancy are a prominent part of the natural history of these diseases. Peritoneal metastases, if not effectively treated, will result in a decreased survival and cause an impaired quality of life. Hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment specifically designed to combat peritoneal metastases. A group of patients who, from a theoretical perspective, may benefit from HIPEC are those patients with a positive peritoneal cytology...
March 2024: International journal of surgery protocols
#10
JOURNAL ARTICLE
S J M van Hootegem, J Chmelo, P C van der Sluis, S M Lagarde, A W Phillips, B P L Wijnhoven
INTRODUCTION: Diagnostic laparoscopy (DL) with peritoneal lavage has been adopted as a standard staging procedure for patients with gastric cancer (GC). Evaluation of the value of DL is important given ongoing improvements in diagnostic imaging and treatment. As contemporary data from European centres are sparse, this retrospective cohort study aimed to assess the yield of DL in patients with potentially curable gastric cancer, and to identify predictive factors for peritoneal metastases...
February 27, 2024: European Journal of Surgical Oncology
#11
JOURNAL ARTICLE
Christoph Andreas Maurer, Mikolaj Walensi, Diana Mattiello, Samuel Andreas Käser, Kathrin Zarfl, Christine Egger
OBJECTIVE: Intraluminally shed viable tumor cells might contribute to anastomotic recurrence in cancer of the esophagus and the cardia. The study aimed to establish a method of esophageal washout and, hence, to reduce intraluminal cancer cells before esophageal anastomosis. METHODS: Forty-eight consecutive patients with esophago-gastric resection for histologically proven cancer of the esophagus or the cardia were included in a prospective, interventional study...
April 2024: European Journal of Surgical Oncology
#12
JOURNAL ARTICLE
Yongjian Lin, Jinlu Liu
BACKGROUND: Gastric cancer (GC) is a frequent malignancy of the gastrointestinal tract. Exploring the potential anoikis mechanisms and pathways might facilitate GC research. PURPOSE: The authors aim to determine the significance of anoikis-related genes (ARGs) in GC prognosis and explore the regulatory mechanisms in epigenetics. METHODS: After describing the genetic and transcriptional alterations of ARGs, we searched differentially expressed genes (DEGs) from the cancer genome atlas and gene expression omnibus databases to identify major cancer marker pathways...
February 20, 2024: IET Systems Biology
#13
JOURNAL ARTICLE
Cisel Aydin Mericoz, Ozgur Can Eren, Ibrahim Kulac, Pinar Firat
BACKGROUND: Cytomorphological evaluation of tissue touch imprints during rapid on-site evaluation or intraoperative pathology consultation has crucial value. However, literature on their utility for molecular testing is limited. In this study, we emphasize a further benefit of touch imprint slides and scrutinize our institutional experience on their use in molecular testing, specifically next generation sequencing (NGS). MATERIALS AND METHODS: NGS-based reports (2019-2023) of Koç University Hospital were retrospectively analyzed and circumstances in which sequencing was conducted on touch imprint slides were retrieved (n = 18)...
February 9, 2024: Diagnostic Cytopathology
#14
JOURNAL ARTICLE
Yuexin Zhang, Wenrui Xie, Wenhong Zheng, Xiaoying Qian, Chengwei Deng
UNLABELLED: In recent years, gastric cancer (GC) is still one of the major public health burdens in the world. It is reported that exosome circular RNA (circRNA) is involved in the GC progression. However, the function and potential mechanism of circGMPS in GC remains unclear and needs further exploration. In this study, we isolated and identified exosomes from serum by TEM, NTA analysis and Western blot. RNA expression was evaluated by qRT-PCR. Western blot was employed to examine protein expression...
February 2024: Cytotechnology
#15
JOURNAL ARTICLE
Atsuhiro Watanabe, Yuji Yamamoto, Senichiro Yanagawa, Momoko Takaya, Jun Amioka, Yuki Kaneko, Mai Nishina, Hiroaki Mashima, Yusuke Sumi, Minoru Yamaki, Manabu Kurayoshi, Akihiko Oshita, Masahiro Nakahara, Toshio Noriyuki
A 72-year-old man visited his local doctor for gastric discomfort. Esophagogastroduodenoscopy revealed a type 3 tumor on the gastric antrum, and histopathological examination revealed a moderately differentiated adenocarcinoma(tub2). The patient was referred to our hospital and CT scan revealed wall thickening with contrast effect in the gastric angle but no enlarged lymph nodes in the region. The patient was diagnosed as cT3N0M0, Stage ⅡB gastric cancer and underwent open distal gastrectomy and D2 lymph node dissection...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#16
JOURNAL ARTICLE
Shusuke Yasuoka, Shinya Urakawa, Junichiro Kato, Shinya Kidogami, Tadafumi Fukata, Hisashi Nishida, Hiroaki Ohigashi, Hiroyoshi Takemoto, Takayuki Fukuzaki
An 82-year-old man presented with right cervical swelling. Cervical ultrasonography revealed several swollen lymph nodes which were diagnosed with adenocarcinoma by fine needle aspiration cytology. Computed tomography showed right axillary lymph nodes were also swelling. Upper and lower gastrointestinal endoscopy found type 0-Ⅱa gastric cancer located at the posterior wall of the middle region. Pathology was HER2-positive moderately differentiated tubular adenocarcinoma. Doublet chemotherapy with S-1 and cisplatin was administered for unresectable gastric cancer(cT1bN0M1, cStage Ⅳb)...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#17
JOURNAL ARTICLE
Makoto Nakai, Fu Urata, Yutaro Hara, Takanobu Akaishi, Chiaki Uchida, Hiroyuki Jin, Masashi Kato, Hiroaki Kawashima, Yoshikazu Toyoki
A case is a female of 61-year-old. She visited her local doctor with a chief complaint of frequent burping. She was hospitalized for gastric cancer with pyloric stenosis. Although open gastrectomy was planned the gastric cancer was unresectable due to pancreatic invasion and peritoneal dissemination. Cytology with abdominal lavage was CY0. She underwent gastrojejunostomy. She was treated by 19 courses of chemotherapy with SOX therapy for 2 years. The tumor reduced, and she underwent distal gastrectomy as conversion surgery...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#18
JOURNAL ARTICLE
Tomohiro Arai, Keisuke Komori, Nozomi Urata, Mamoru Uchiyama, Yoshihiro Suzuki, Yasushi Rino, Aya Saito
In a 79-year-old man, upper gastrointestinal endoscopy and CT revealed an entire circumferential type 3 tumor with stenosis from the lower thoracic esophagus to the abdominal esophagus. He was diagnosed with esophageal adenocarcinoma and underwent middle and lower esophageal resection and 2 regional lymph node dissections. The postoperative pathological diagnosis was poorly differentiated adenocarcinoma, pT3N0M0, pStage ⅡA esophagogastric junction cancer(Siewert type Ⅱ). The patient was followed-up without postoperative adjuvant chemotherapy, following the Japanese Gastric Cancer Treatment Guidelines 2021(6th edition)...
January 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#19
JOURNAL ARTICLE
Karen Van Der Sluis, Steven N Taylor, Liudmila L Kodach, Jolanda M van Dieren, Ignace H J T de Hingh, Bas P L Wijnhoven, Rob H A Verhoeven, Marieke A Vollebergh, Johanna W van Sandick
BACKGROUND: The clinical significance of tumor-positive peritoneal cytology (CYT+) in gastric cancer (GC) patients is unclear. This nationwide cohort study aimed to i) assess the frequency of cytological analysis at staging laparoscopy; ii) determine the prevalence of CYT+GC; and iii) compare overall survival (OS) in CYT+ patients versus those with (PM+) and those without (PM-) macroscopic peritoneal disease. METHODS: All patients diagnosed with cT1-4, cN0-2 and M0 or synchronous PM GC between 2016-2021 were identified in the Netherlands Cancer Registry database and linked to the nationwide pathology database...
March 2024: European Journal of Cancer
#20
Song Liang, Xinan Fang, Pin Jiang, Li Yang, Xiaoqi Li, Xun Xu, Yongkang Liang, Chen Li, Yanan Zheng
BACKGROUND: Peritoneal metastases (PMs) are the most frequent metastatic pattern with a very poor prognosis in stage IV gastric cancer (GC). An effective therapeutic option has yet to be established. Combination therapy of anti-angiogenesis therapy, immunotherapy and chemotherapy was first used in advanced GC for perioperative treatment in this case. CASE DESCRIPTION: A 39-year-old man was diagnosed with stage IV GC with PM (CY1, P1) and the patient had an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 1 and adequate organ function...
December 31, 2023: Journal of Gastrointestinal Oncology
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