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https://www.readbyqxmd.com/read/29332786/recent-advances-and-developments-on-integrating-nanotechnology-with-chemiluminescence-assays
#1
REVIEW
Ashish Tiwari, S J Dhoble
Chemiluminescence (CL) techniques are extensively utilized for detection of analytes due to their high sensitivity, rapidity and selectivity. With the advent of nanotechnology and incorporation of the nanoparticles in the CL system has revolutionized the assays due to their unique optical and mechanical properties. Several CL-based reactions have been developed where these nanoparticle based CL sensors have evolved as excellent prospects for sensing in various analytical applications. This review article addresses the nanoparticles based CL detection system that are recently developed, the mechanisms has been summarized and the role of luminophors have been discussed...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29332396/an-electrochemical-system-for-the-study-of-trans-plasma-membrane-electron-transport-in-whole-eukaryotic-cells
#2
Harry G Sherman, Carolyn Jovanovic, Snow Stolnik, Frankie James Rawson
The development of new assays to study trans-plasma membrane electron transport (tPMET) in eukaryotic systems is paramount for a number reasons, which include the further understanding of the underlying biology which can then potentially be applied to innovate technological advancements in biosensing, microbial fuel, and pharmaceutical fields. The current literature provides methodology to study these systems that hinges upon mitochondrial knockout genotypes, or the detection of ferrocyanide using colorimetric methods...
January 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29329706/unattended-reaction-monitoring-using-an-automated-microfluidic-sampler-and-on-line-liquid-chromatography
#3
Darshan C Patel, Yaqi Fara Lyu, Jorge Gandarilla, Steve Doherty
In-process sampling and analysis is an important aspect of monitoring kinetic profiles and impurity formation or rejection, both in development and during commercial manufacturing. In pharmaceutical process development, the technology of choice for a substantial portion of this analysis is high-performance liquid chromatography (HPLC). Traditionally, the sample extraction and preparation for reaction characterization have been performed manually. This can be time consuming, laborious, and impractical for long processes...
April 3, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29327264/inline-uv-vis-spectroscopy-as-pat-tool-for-hot-melt-extrusion
#4
Jens Wesholowski, Sebastian Prill, Andreas Berghaus, Markus Thommes
Hot-melt extrusion on co-rotating twin screw extruders is a focused technology for the production of pharmaceuticals in the context of Quality by Design. Since it is a continuous process, the potential for minimizing product quality fluctuation is enhanced. A typical application of hot-melt extrusion is the production of solid dispersions, where an active pharmaceutical ingredient (API) is distributed within a polymer matrix carrier. For this dosage form, the product quality is related amongst others to the drug content...
January 11, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29326083/ligandomics-a-paradigm-shift-in-biological-drug-discovery
#5
REVIEW
Wei Li, Iok-Hou Pang, Mario Thiego F Pacheco, Hong Tian
As productivity of pharmaceutical research and development (R&D) for small-molecule drugs declines, the trend in drug discovery strategies is shifting towards biologics, which predominantly target secreted or cell surface proteins. Receptors and ligands are the most-valuable drug targets. In contrast to conventional approaches of discovering one ligand at a time, the emerging technology of ligandomics can systematically map disease-selective cellular ligands in the absence of molecular probes. Biologics targeting these ligands with disease selectivity have the advantages of high efficacy, minimal adverse effects, wide therapeutic indices, and low safety-related attrition rates...
January 8, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29325925/microfluidic-approaches-for-the-characterization-of-therapeutic-proteins
#6
REVIEW
Marie R G Kopp, Paolo Arosio
In the last decades the pharmaceutical market has experienced an increase in the number of therapeutic proteins. The high activity and selectivity of these macromolecules is often achieved at the expense of complex structures, which exhibit several biophysical properties that must be carefully controlled and optimized for the successful development of these drugs as well as for guaranteeing their quality and safety. This need has motivated the application of a variety of biophysical techniques to analyze properties of therapeutic proteins and protein solutions including interactions, aggregation, solubility, viscosity and thermal stability...
January 8, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29318817/-application-of-image-recognition-technology-in-census-of-national-traditional-chinese-medicine-resources
#7
Xiao-Bo Zhang, Xiao-Guang Ge, Yan Jin, Ting-Ting Shi, Hui Wang, Meng Li, Zhi-Xian Jing, Lan-Ping Guo, Lu-Qi Huang
With the development of computer and image processing technology, image recognition technology has been applied to the national medicine resources census work at all stages.Among them: ①In the preparatory work, in order to establish a unified library of traditional Chinese medicine resources, using text recognition technology based on paper materials, be the assistant in the digitalization of various categories related to Chinese medicine resources; to determine the representative area and plots of the survey from each census team, based on the satellite remote sensing image and vegetation map and other basic data, using remote sensing image classification and other technical methods to assist in determining the key investigation area...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29316700/sea-anemones-quiet-achievers-in-the-field-of-peptide-toxins
#8
REVIEW
Peter J Prentis, Ana Pavasovic, Raymond S Norton
Sea anemones have been understudied as a source of peptide and protein toxins, with relatively few examined as a source of new pharmacological tools or therapeutic leads. This is surprising given the success of some anemone peptides that have been tested, such as the potassium channel blocker from Stichodactyla helianthus known as ShK. An analogue of this peptide, ShK-186, which is now known as dalazatide, has successfully completed Phase 1 clinical trials and is about to enter Phase 2 trials for the treatment of autoimmune diseases...
January 8, 2018: Toxins
https://www.readbyqxmd.com/read/29310227/quantitative-analysis-of-drug-distribution-by-ambient-mass-spectrometry-imaging-method-with-signal-extinction-normalization-strategy-and-inkjet-printing-technology
#9
Zhigang Luo, Jingjing He, Jiuming He, Lan Huang, Xiaowei Song, Xin Li, Zeper Abliz
Quantitative mass spectrometry imaging (MSI) is a robust approach that provides both quantitative and spatial information for drug candidates' research. However, because of complicated signal suppression and interference, acquiring accurate quantitative information from MSI data remains a challenge, especially for whole-body tissue sample. Ambient MSI techniques using spray-based ionization appear to be ideal for pharmaceutical quantitative MSI analysis. However, it is more challenging, as it involves almost no sample preparation and is more susceptible to ion suppression/enhancement...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29301580/pharmacokinetics-comparison-of-two-pegylated-interferon-alfa-formulations-in-healthy-volunteers
#10
Marisa Boff Costa, Paulo Dornelles Picon, Guilherme Becker Sander, Hugo Nodarse Cuni, Carmen Valenzuela Silva, Rolando Páez Meireles, Ana Carolina Magalhães Andrade Góes, Nadia Maria Batoreu, Maria de Lourdes de Sousa Maia, Elizabeth Maciel Albuquerque, Denise Cristina de Souza Matos, Pedro Lopez Saura
BACKGROUND: Several countries have used pegylation technology to improve the pharmacokinetic properties of essential drugs. Recently, a novel interferon alfa-2b protein conjugated to four-branched 12 kDa polyethylene glycol molecules was developed jointly between Cuba and Brazil. The aim of this study was to compare the pharmacokinetic properties of BIP48 (pegylated interferon alfa-2b from Bio-Manguinhos/Fiocruz, Brazil) to those of PEGASYS® (commercially available pegylated interferon alfa-2a from Roche Pharmaceutical)...
January 4, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29301230/electronic-tongue-a-tool-for-all-tastes
#11
REVIEW
Marta Podrażka, Ewa Bączyńska, Magdalena Kundys, Paulina S Jeleń, Emilia Witkowska Nery
Electronic tongue systems are traditionally used to analyse: food products, water samples and taste masking technologies for pharmaceuticals. In principle, their applications are almost limitless, as they are able to almost completely reduce the impact of interferents and can be applied to distinguish samples of extreme complexity as for example broths from different stages of fermentation. Nevertheless, their applications outside the three principal sample types are, in comparison, rather scarce. In this review, we would like to take a closer look on what are real capabilities of electronic tongue systems, what can be achieved using mixed sensor arrays and by introduction of biosensors or molecularly imprinted polymers in the matrix...
December 31, 2017: Biosensors
https://www.readbyqxmd.com/read/29290567/recent-advances-in-the-applications-of-vibrational-spectroscopic-imaging-and-mapping-to-pharmaceutical-formulations
#12
Andrew V Ewing, Sergei G Kazarian
Vibrational spectroscopic imaging and mapping approaches have continued in their development and applications for the analysis of pharmaceutical formulations. Obtaining spatially resolved chemical information about the distribution of different components within pharmaceutical formulations is integral for improving the understanding and quality of final drug products. This review aims to summarise some key advances of these technologies over recent years, primarily since 2010. An overview of FTIR, NIR, terahertz spectroscopic imaging and Raman mapping will be presented to give a perspective of the current state-of-the-art of these techniques for studying pharmaceutical samples...
December 21, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29288810/zinc-delivery-from-non-woven-fibres-within-a-therapeutic-nipple-shield
#13
Theresa Maier, Rebekah L Scheuerle, Daniel Markl, Sylvaine Bruggraber, Axel Zeitler, Ljiljana Fruk, Nigel K H Slater
A Therapeutic Nipple Shield (TNS) was previously developed to respond to the global need for new infant therapeutic delivery technologies. However, the release efficiency for the same Active Pharmaceutical Ingredient (API) from different therapeutic matrices within the TNS formulation has not yet been investigated. To address this, in-vitro release of elemental zinc into human milk from two types of Texel non-woven fibre mats of varying thickness and different gram per square meter values, placed inside the TNS was explored and compared to the release from zinc-containing rapidly disintegrating tablets...
December 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29288733/ophthalmic-gels-past-present-and-future
#14
Ali A Al-Kinani, Ghada Zidan, Naba Elsaid, Ali Seyfoddin, Adam W G Alani, Raid G Alany
Aqueous gels formulated using hydrophilic polymers (hydrogels) along with those based on stimuli responsive polymers (in situ gelling or gel forming systems) continue to attract increasing interest for various eye health-related applications. They allow the incorporation of a variety of ophthalmic pharmaceuticals to achieve sustained and therapeutic levels of drugs and bioactives at target ocular sites. The integration of sophisticated drug delivery technologies such as nanotechnology-based, intelligent and environment responsive systems can extend current treatment duration to provide more clinically relevant time courses (weeks and months instead of hours and days) which will inevitably reduce dose frequency, increase patient compliance and improve clinical outcomes...
December 27, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29288092/real-time-process-monitoring-in-a-semi-continuous-fluid-bed-dryer-microwave-resonance-technology-versus-near-infrared-spectroscopy
#15
Johanna Peters, Andreas Teske, Wolfgang Taute, Claas Döscher, Michael Höft, Reinhard Knöchel, Jörg Breitkreutz
The trend towards continuous manufacturing in the pharmaceutical industry is associated with an increasing demand for advanced control strategies. It is a mandatory requirement to obtain reliable real-time information on critical quality attributes (CQA) during every process step as the decision on diversion of material needs to be performed fast and automatically. Where possible, production equipment should provide redundant systems for in-process control (IPC) measurements to ensure continuous process monitoring even if one of the systems is not available...
December 26, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29287930/ptl401-a-new-formulation-based-on-pro-nano-dispersion-technology-improves-oral-cannabinoids-bioavailability-in-healthy-volunteers
#16
Jacob Atsmon, Irina Cherniakov, Dvora Izgelov, Amnon Hoffman, Abraham J Domb, Lisa Deutsch, Frederic Deutsch, Daphna Heffetz, Hagit Sacks
There is growing clinical interest in developing and commercializing pharmaceutical-grade cannabinoid products, containing primarily tetrahydrocannabinol (THC) and cannabidiol (CBD). The oral bioavailability of THC and CBD is very low due to extensive "first pass" metabolism. A novel oral THC and CBD formulation, PTL401, utilizing an advanced self-emulsifying oral drug delivery system, was designed to circumvent the "first pass" effect. In this study, the bioavailability of THC and CBD from the PTL401 capsule was compared with similar doses from a marketed reference oromucosal spray (Sativex®)...
December 26, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29285948/translation-of-combination-nanodrugs-into-nanomedicines-lessons-learned-and-future-outlook
#17
Qingxin Mu, Jesse Yu, Lisa A McConnachie, John C Kraft, Yu Gao, Gaurav K Gulati, Rodney J Y Ho
The concept of nanomedicine is not new. For instance, some nanocrystals and colloidal drug molecules are marketed that improve pharmacokinetic characteristics of single-agent therapeutics. For the past two decades, the number of research publications on single-agent nanoformulations has grown exponentially. However, formulations advancing to preclinical and clinical evaluations that lead to therapeutic products has been limited. Chronic diseases such as cancer and HIV/AIDS require drug combinations, not single agents, for durable therapeutic responses...
December 29, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29284701/more-than-bar-codes-integrating-global-standards-based-bar-code-technology-into-national-health-information-systems-in-ethiopia-and-pakistan-to-increase-end-to-end-supply-chain-visibility
#18
Liuichi Hara, Ramy Guirguis, Keith Hummel, Monica Villanueva
The United Nations Population Fund (UNFPA) and the United States Agency for International Development (USAID) DELIVER PROJECT work together to strengthen public health commodity supply chains by standardizing bar coding under a single set of global standards. From 2015, UNFPA and USAID collaborated to pilot test how tracking and tracing of bar coded health products could be operationalized in the public health supply chains of Ethiopia and Pakistan and inform the ecosystem needed to begin full implementation...
December 28, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/29284286/10-years-eu-regulation-of-pediatric-medicines-impact-on-cardiovascular-drug-formulations
#19
Yasmin Thabet, Marta Slavkova, Jörg Breitkreutz
Child-appropriate drug formulations are mandatory for an efficient and safe drug therapy in children. Since the implementation of supportive legislations development of novel drug formulations has significantly been enforced despite the fact that children are a heterogeneous group of patients with varying needs according to age, maturation and disease. Areas covered: In this review, recent advances and current strategies are evaluated how to overcome the specific hurdles in pediatric drug development. For cardiovascular diseases as an example, EMA's decisions on pediatric investigation plans (PIPs) have been evaluated...
December 28, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29278928/exploring-plant-tissue-culture-in-withania-somnifera-l-dunal-in-vitro-propagation-and-secondary-metabolite-production
#20
Shasmita, Manoj K Rai, Soumendra K Naik
Withania somnifera (L.) Dunal (family: Solanaceae), commonly known as "Indian Ginseng", is a medicinally and industrially important plant of the Indian subcontinent and other warmer parts of the world. The plant has multi-use medicinal potential and has been listed among 36 important cultivated medicinal plants of India that are in high demand for trade due to its pharmaceutical uses. The medicinal importance of this plant is mainly due to the presence of different types of steroidal lactones- withanolides in the roots and leaves...
December 26, 2017: Critical Reviews in Biotechnology
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