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https://www.readbyqxmd.com/read/27910966/stem-cell-and-regenerative-medicine-global-conference-scrgc-2016-august-23-24-2016-gyeonggi-do-korea
#1
A Vertès
In its third edition, the Stem Cell and Regenerative Medicine Global Conference (SCRGC) organized by the Global Stem Cell & Regenerative Medicine Acceleration Center (GSRAC) was focused on breaking barriers to accelerate the pace of innovation and development of the regenerative medicine industry. GSRAC is both a think tank and a global network of key opinion leaders from the public and the private sectors. GSRAC was commissioned in 2011 by the Ministry of Health and Welfare (MOHW) of Korea. GSRAC's primary mission is to enable and accelerate the delivery of innovative technologies to patients who are affected by currently untreatable diseases...
October 2016: Drugs of Today
https://www.readbyqxmd.com/read/27909447/stem-cell-therapy-a-prospective-treatment-for-alzheimer-s-disease
#2
REVIEW
Ji Han Lee, Il-Hoan Oh, Hyun Kook Lim
Alzheimer's disease (AD) without cure remains as a serious health issue in the modern society. The major neuropathological alterations in AD are characterized by chronic neuroinflammation and neuronal loss due to neurofibrillary tangles (NFTs) of abnormally hyperphosphorylated tau, plaques of β-amyloid (Aβ) and various metabolic dysfunctions. Due to the multifaceted nature of AD pathology and our limited understanding on its etiology, AD is difficult to be treated with currently available pharmaceuticals...
November 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27905174/zirconium-iv-catalyzed-ring-opening-of-on-dna-epoxides-in-water
#3
Lijun Fan, Christopher P Davie
DNA-encoded library technology (ELT) has spurred wide interest in the pharmaceutical industry as a powerful tool for hit and lead generation. In recent years a number of "DNA-compatible" chemical modifications have been published and used to synthesize vastly diverse screening libraries. Herein we report a newly developed, zirconium tetrakis(dodecyl sulfate) [Zr(DS)4] catalyzed ring-opening of on-DNA epoxides in water with amines, including anilines. Subsequent cyclization of the resulting on-DNA β-amino alcohols leads to a variety of biologically interesting, non-aromatic heterocycles...
November 30, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27896684/use-of-spray-dried-dispersions-in-early-pharmaceutical-development-theoretical-and-practical-challenges
#4
Jinjiang Li, Dhaval Patel, George Wang
Spray-dried dispersions (SDDs) have become an important formulation technology for the pharmaceutical product development of poorly water-soluble (PWS) compounds. Although this technology is now widely used in the industry, especially in the early-phase development, the lack of mechanistic understanding still causes difficulty in selecting excipients and predicting stability of SDD-based drug products. In this review, the authors aim to discuss several principles of polymer science pertaining to the development of SDDs, in terms of selecting polymers and solvents, optimizing drug loading, as well as assessing physical stability on storage and supersaturation maintenance after dissolution, from both thermodynamic and kinetic considerations...
November 28, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27895967/medical-representatives-intention-to-use-information-technology-in-pharmaceutical-marketing
#5
Eun-Seon Kwak, Hyejung Chang
OBJECTIVES: Electronic detailing (e-detailing), the use of electronic devices to facilitate sales presentations to physicians, has been adopted and expanded in the pharmaceutical industry. To maximize the potential outcome of e-detailing, it is important to understand medical representatives (MRs)' behavior and attitude to e-detailing. This study investigates how information technology devices such as laptop computers and tablet PCs are utilized in pharmaceutical marketing, and it analyzes the factors influencing MRs' intention to use devices...
October 2016: Healthcare Informatics Research
https://www.readbyqxmd.com/read/27890703/vitamin-b6-metabolism-in-microbes-and-approaches-for-fermentative-production
#6
REVIEW
Jonathan Rosenberg, Till Ischebeck, Fabian M Commichau
Vitamin B6 is a designation for the six vitamers pyridoxal, pyridoxine, pyridoxamine, pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate, and pyridoxamine. PLP, being the most important B6 vitamer, serves as a cofactor for many proteins and enzymes. In contrast to other organisms, animals and humans have to ingest vitamin B6 with their food. Several disorders are associated with vitamin B6 deficiency. Moreover, pharmaceuticals interfere with metabolism of the cofactor, which also results in vitamin B6 deficiency...
November 24, 2016: Biotechnology Advances
https://www.readbyqxmd.com/read/27885934/the-path-to-producing-pharmaceuticals-from-natural-products-uncovered-by-academia-from-the-perspective-of-a-science-coordinator
#7
Akihiko Fujie
To actualize the invention of all-Japanese medicines, the Department of Innovative Drug Discovery and Development (iD3) in the Japan Agency for Medical Research and Development (AMED) serves as the headquarters for the Drug Discovery Support Network. iD3 assists with creating research strategies for the seeds of medicines discovered by academia and provides technological support, intellectual property management, and aid for applying the seeds through industry-led efforts. In this review, from the perspective of a science coordinator, I will describe the current activities of the drug discovery support network and iD3 as well as the challenges and future developments of pharmaceutical research and development using the natural product drug discovery method...
January 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27881063/membrane-bioreactors-for-pharmaceutical-applications-optically-pure-enantiomers-production
#8
Emma Piacentini, Rosalinda Mazzei, Lidietta Giorno
In biological systems, recognition at molecular level is governed by chiral interactions. Therefore, optical isomers have very different effect in natural systems. For example, one can have beneficial effect while the other can be very harmful. For these reasons, chiral drugs nowadays are mainly admitted in the optically pure form. Given these requirements, it is clear why demand for chiral drugs has grown dramatically and the single-enantiomer drug segment has become an important part of the overall pharmaceutical market...
November 23, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27876365/midyear-commentary-on-trends-in-drug-delivery-and-clinical-translational-medicine-growth-in-biosimilar-complex-injectable-drug-formulation-products-within-evolving-collaborative-regulatory-interagency-fda-ftc-and-doj-practices-and-enforcement
#9
Rodney J Y Ho
Before the 2009 Biologics Price Competition and Innovation Act that enabled the U.S. Federal Drug Administration (FDA) to create the 351(k) Biologic License Application-an abbreviated biosimilar approval process, FDA approved follow-on biomolecule products such as beta-interferon, glucagon, hyaluronidase, and somatropin (human growth hormone) under varying and evolving rules. With the 351(k) Biologic License Application biosimilar approval process in place, currently, there are 4 (licensed in 2015-2016) biosimilars available, namely Neupogen (filgrastim; $1 B/y), Humira (adalumumab; $14...
November 19, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27872965/novel-technologies-for-optimal-strain-breeding
#10
Michael Bott, Lothar Eggeling
The implementation of a knowledge-based bioeconomy requires the rapid development of highly efficient microbial production strains that are able to convert renewable carbon sources to value-added products, such as bulk and fine chemicals, pharmaceuticals, or proteins at industrial scale. Starting from classical strain breeding by random mutagenesis and screening in the 1950s via rational design by metabolic engineering initiated in the 1970s, a range of powerful new technologies have been developed in the past two decades that can revolutionize future strain engineering...
November 22, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27869291/managing-innovation-to-maximize-value-along-the-discovery-translation-application-continuum
#11
S A Waldman, A Terzic
Success in pharmaceutical development led to a record 51 drugs approved in the past year, surpassing every previous year since 1950. Technology innovation enabled identification and exploitation of increasingly precise disease targets ensuring next generation diagnostic and therapeutic products for patient management. The expanding biopharmaceutical portfolio stands, however, in contradistinction to the unsustainable costs that reflect remarkable challenges of clinical development programs. This annual Therapeutic Innovations issue juxtaposes advances in translating molecular breakthroughs into transformative therapies with essential considerations for lowering attrition and improving the cost-effectiveness of the drug-development paradigm...
November 21, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27866007/continuous-manufacturing-via-hot-melt-extrusion-and-scale-up-regulatory-matters
#12
REVIEW
Mohammed Maniruzzaman, Ali Nokhodchi
Currently, because globalization, the pharmaceutical industry is facing enormous challenges to comply with regulatory matters. Reduced patent life and overall decreased profitability of newly discovered drugs are also forcing the pharmaceutical industry to shorten the drug development time with maximum throughput. Therefore, continuous manufacturing (CM) processes via hot melt extrusion (HME) can be a promising alternative for achieving these goals. HME offers solvent-free green technology with a process that is easy to scale up...
November 16, 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/27865609/recent-advances-in-lipid-based-vesicles-and-particulate-carriers-for-topical-and-transdermal-application
#13
REVIEW
Shashank Jain, Niketkumar Patel, Mansi K Shah, Pinak Khatri, Namrata Vora
In the recent decade, skin delivery (topical and transdermal) has gained an unprecedented popularity, especially due to increased incidences of chronic skin diseases, demand for targeted and patient compliant delivery, and interest in life cycle management strategies among pharmaceutical companies. Literature review of recent publications indicates that among various skin delivery systems, lipid-based delivery systems (vesicular carriers and lipid particulate systems) have been the most successful. Vesicular carriers consist of liposomes, ultradeformable liposomes, and ethosomes, while lipid particulate systems consist of lipospheres, solid lipid nanoparticles, and nanostructured lipid carriers...
November 16, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27852893/philip-morris-research-on-precursors-to-the-modern-e-cigarette-since-1990
#14
Lauren M Dutra, Rachel Grana, Stanton A Glantz
BACKGROUND: Use of electronic cigarettes (e-cigarettes) is increasing rapidly. Chinese pharmacist Hon Lik is frequently cited as inventing the modern e-cigarette in 2003. However, tobacco companies have developed electronic nicotine delivery systems since at least 1963. METHODS: We searched the University of California San Francisco Truth (formerly Legacy) Tobacco Industry Documents beginning with the terms 'electric cigarette' and 'electronic cigarettes', 'e-cigarette', 'smokeless cigarettes', 'nicotine aerosol', 'tobacco aerosol', and 'vaping' and then expanded the search using snowball sampling...
November 15, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27849060/large-scale-identification-of-human-protein-function-using-topological-features-of-interaction-network
#15
Zhanchao Li, Zhiqing Liu, Wenqian Zhong, Menghua Huang, Na Wu, Yun Xie, Zong Dai, Xiaoyong Zou
The annotation of protein function is a vital step to elucidate the essence of life at a molecular level, and it is also meritorious in biomedical and pharmaceutical industry. Developments of sequencing technology result in constant expansion of the gap between the number of the known sequences and their functions. Therefore, it is indispensable to develop a computational method for the annotation of protein function. Herein, a novel method is proposed to identify protein function based on the weighted human protein-protein interaction network and graph theory...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27847672/development-of-hydrophilic-interaction-liquid-chromatography-method-for-the-analysis-of-moxonidine-and-its-impurities
#16
Slavica Filipic, Milica Elek, Marija Popović, Katarina Nikolic, Danica Agbaba
Fast and simple hydrophilic interaction liquid chromatography (HILIC) method was developed and validated for the analysis of moxonidine and its four impurities (A, B, C, and D) in pharmaceutical dosage form. All experiments were performed on the Agilent Technologies 1200 high-performance liquid chromatography (HPLC) system using Zorbax RX-SIL, 250 mm × 4.6 mm, 5 μm column as stationary phase (T = 25°C, F = 1 mL/min, and λ = 255 nm), and mixture of acetonitrile and 40 mM ammonium formate buffer (pH 2...
2016: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/27847300/a-review-of-the-progress-and-pitfalls-of-fda-policy-process-planning-a-pathway-for-pharmaceutical-interventions-for-hearing-loss-development
#17
Tanisha L Hammill
The Federal Food and Drug Administration, or FDA is generally considered a powerful gatekeeper, able to deliver or withhold life-saving cures and create or destroy economic windfalls. As the decades go by, and technologies, diseases, public health demands, and politics evolve, we can identify patterns of change, action and inter-action among some of these traditional stakeholders in the FDA's policy sphere. A careful examination of this agency's colorful history can shed light on central features of the agency's policy process, which has been quite receptive to its stakeholders and adaptive to change over the decades and, in turn, show the way for development in lanes which do not fit neatly into the current paradigms offered by the agency...
November 12, 2016: Hearing Research
https://www.readbyqxmd.com/read/27836489/sorbent-device-matrix-and-application-in-microextraction-by-packed-sorbent-meps-a-review
#18
Liu Yang, Rana Said, Mohamed Abdel-Rehim
Microextraction by packed sorbent (MEPS) is a miniaturized form of the solid-phase extraction, is a green sample pretreatment technology. This green sample pretreatment technology has been widely accepted and used by several research groups online or offline as a sample preparation technique before instrument analysis. MEPS reduces the sample volume size and can easily be connected with different chromatographic techniques without modification. The sorbent bed in MEPS is integrated into a liquid handling syringe that allows for low void volume sample manipulations either manually or in combination with laboratory robotics...
November 5, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27829340/preclinical-evaluation-of-avn-322-novel-and-highly-selective-5-ht6-receptor-antagonist-for-the-treatment-of-alzheimer-s-disease
#19
Alexandre V Ivachtchenko, Yan A Ivanenkov, Mark S Veselov
Alla Chem LLC, Hallandale Beach, USA; bAvineuro Pharmaceuticals, Inc., Hallandale Beach, USA; cMoscow Institute of Physics and Technology (State University), Dolgoprudny city, Russian Federation. Abstract: In recent years, 5-hydroxytryptamine subtype 6 receptor (5-HT6 receptor, 5-HT6R) has rapidly emerged as a promising therapeutic target for the treatment of neuropathological disorders, including Alzheimer's disease (AD). Evidence indicates that 5-HT6 receptors are deeply implicated in the processes of learning and memory, while 5-HT6R antagonists were shown to improve cognition in animal models of cognitive impairment...
November 7, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27828683/scientific-and-technological-capabilities-in-health-related-areas-opportunities-challenges-and-interactions-with-the-industrial-sector
#20
Marco Antonio Vargas, Jorge Britto
Characterization of the scientific and technological infrastructure in health and its interactions with the industrial sector provides key elements for understanding the dynamics of innovation in health. This study conducts an exploratory analysis of the potentialities and limitations associated with scientific and technological capabilities in the health area in Brazil and the different links between the scientific and industrial sectors in health. The analysis points to important growth in internationally indexed research output, especially in certain areas such as pharmaceutics, public health, genetics, morphology, physiology, and microbiology...
November 3, 2016: Cadernos de Saúde Pública
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