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https://www.readbyqxmd.com/read/28814799/on-mechanism-behind-uv-a-light-enhanced-antibacterial-activity-of-gallic-acid-and-propyl-gallate-against-escherichia-coli-o157-h7
#1
Qingyang Wang, Erick Falcao de Oliveira, Solmaz Alborzi, Luis J Bastarrachea, Rohan V Tikekar
Possible mechanisms behind the enhanced antimicrobial activity of gallic acid (GA) and its ester propyl gallate (PG) in the presence of UV-A light against Escherichia coli O157:H7 were investigated. GA by itself is a mild antimicrobial and has a pro-oxidant ability. We found that the presence of UV-A light increases the uptake of GA by the bacteria. Once GA is internalized, the interaction between GA and UV-A induces intracellular ROS formation, leading to oxidative damage. Concurrently, GA + UV-A also inhibits the activity of superoxide dismutase (SOD), magnifying the imbalance of redox status of E...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811032/recent-advancements-and-future-trends-in-environmental-analysis-sample-preparation-liquid-chromatography-and-mass-spectrometry
#2
REVIEW
Virginia Pérez-Fernández, Lucia Mainero Rocca, Pierpaolo Tomai, Salvatore Fanali, Alessandra Gentili
Among the thousands of chemicals having potential to enter the environment, the NORMAN network has identified at least 700 substances categorized into 20 classes in the European surface waters. Pesticides, pharmaceuticals, disinfection by-products, wood preservation and industrial chemicals are the prominent classes. Since the impact of these substances on aquatic life and human health might be dramatic, action is urgently required at multiple levels; one of them is just related to the development of more and more sensible and selective analytical methods...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28800196/furthering-knowledge-of-seaweed-growth-and-development-to-facilitate-sustainable-aquaculture
#3
Bénédicte Charrier, Maria Helena Abreu, Rita Araujo, Annette Bruhn, Juliet C Coates, Olivier De Clerck, Christos Katsaros, Rafael R Robaina, Thomas Wichard
Macroalgae (seaweeds) are the subject of increasing interest for their potential as a source of valuable, sustainable biomass in the food, feed, chemical and pharmaceutical industries. Compared with microalgae, the pace of knowledge acquisition in seaweeds is slower despite the availability of whole-genome sequences and model organisms for the major seaweed groups. This is partly a consequence of specific hurdles related to the large size of these organisms and their slow growth. As a result, this basic scientific field is falling behind, despite the societal and economic importance of these organisms...
August 11, 2017: New Phytologist
https://www.readbyqxmd.com/read/28799951/surface-engineered-blood-adsorption-device-for-hyperphosphatemia-treatment
#4
Quan Shi, Michael Jolly, Marian G Mccord, Melanie S Joy
Correspondence: Melanie S. Joy, PharmD, PhD, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Mail Stop C238, Room V20-4108, 12850 East Montview Blvd, Aurora, CO 80045. Email: Melanie.Joy@ucdenver.eduThe research employed surface engineering methods to develop, optimize, and characterize a novel textile-based hemoadsorption device for hyperphosphatemia in hemodialysis-dependent end-stage kidney disease. Phosphate adsorbent fabrics (PAFs) were prepared by thermopressing alumina powders to polyester filtration fabrics and treatment with trimesic acid (TMA)...
August 8, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28798911/tissue-engineering-approaches-in-the-design-of-healthy-and-pathological-in-vitro-tissue-models
#5
REVIEW
Silvia Caddeo, Monica Boffito, Susanna Sartori
In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined to develop bioartificial substitutes for organs and tissues, which can in turn be applied in regenerative medicine, pharmaceutical, diagnostic, and basic research to elucidate fundamental aspects of cell functions in vivo or to identify mechanisms involved in aging processes and disease onset and progression. The complex three-dimensional (3D) microenvironment in which cells are organized in vivo allows the interaction between different cell types and between cells and the extracellular matrix, the composition of which varies as a function of the tissue, the degree of maturation, and health conditions...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28797957/uv-imaging-in-pharmaceutical-analysis
#6
REVIEW
Jesper Østergaard
UV imaging provides spatially and temporally resolved absorbance measurements, which are highly useful in pharmaceutical analysis. Commercial UV imaging instrumentation was originally developed as a detector for separation sciences, but the main use is in the area of in vitro dissolution and release testing studies. The review covers the basic principles of the technology and summarizes the main applications in relation to intrinsic dissolution rate determination, excipient compatibility studies and in vitro release characterization of drug substances and vehicles intended for parenteral administration...
August 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28780997/electrochemical-carbon-based-nanosensors-a-promising-tool-in-pharmaceutical-and-biomedical-analysis
#7
REVIEW
Sevinc Kurbanoglu, Sibel A Ozkan
Nanotechnology has become very popular in the sensor fields in recent times. It is thought that the utilization of such technologies, as well as the use of nanosized materials, could well have beneficial effects for the performance of sensors. Nano-sized materials have been shown to have a number of novel and interesting physical and chemical properties. Low-dimensional nanometer-sized materials and systems have defined a new research area in condensed-matter physics within past decades. Apart from the aforesaid categories of materials, there exist various materials of different types for fabricating nanosensors...
June 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28774216/3d-printed-drug-delivery-devices-perspectives-and-technical-challenges
#8
Mirja Palo, Jenny Holländer, Jaakko Suominen, Jouko Yliruusi, Niklas Sandler
The technological advancements in the pharmaceutical field are constantly improving and provide various possibilities for meeting the needs of personalized drug therapy. The three-dimensional (3D) printing technology has endless potential in the fabrication of patient-specific drug delivery devices (DDD) and dosage forms as the technological development is progressing. Moreover, the rapidly evolving research on 3D printed DDD has enabled us to determine several challenges related to the manufacturing and marketing of personalized drug delivery systems...
August 4, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28773212/production-of-high-value-nanoparticles-via-biogenic-processes-using-aquacultural-and-horticultural-food-waste
#9
REVIEW
Purabi R Ghosh, Derek Fawcett, Shashi B Sharma, Gerrard E J Poinern
The quantities of organic waste produced globally by aquacultural and horticulture are extremely large and offer an attractive renewable source of biomolecules and bioactive compounds. The availability of such large and diverse sources of waste materials creates a unique opportunity to develop new recycling and food waste utilisation strategies. The aim of this review is to report the current status of research in the emerging field of producing high-value nanoparticles from food waste. Eco-friendly biogenic processes are quite rapid, and are usually carried out at normal room temperature and pressure...
July 25, 2017: Materials
https://www.readbyqxmd.com/read/28766182/lipidomics-and-anti-trypanosomatid-chemotherapy
#10
REVIEW
Michael Biagiotti, Sedelia Dominguez, Nader Yamout, Rachel Zufferey
BACKGROUND: Trypanosomatids such as Leishmania, Trypanosoma brucei and Trypanosoma cruzi belong to the order Kinetoplastida and are the source of many significant human and animal diseases. Current treatment is unsatisfactory and is compromised by the rising appearance of drug resistant parasites. Novel and more effective chemotherapeutics are urgently needed to treat and prevent these devastating diseases, which relies on the identification of essential, parasite specific targets that are absent in the host...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28764869/intelligent-computational-model-for-classification-of-sub-golgi-protein-using-oversampling-and-fisher-feature-selection-methods
#11
Jamal Ahmad, Faisal Javed, Maqsood Hayat
Golgi is one of the core proteins of a cell, constitutes in both plants and animals, which is involved in protein synthesis. Golgi is responsible for receiving and processing the macromolecules and trafficking of newly processed protein to its intended destination. Dysfunction in Golgi protein is expected to cause many neurodegenerative and inherited diseases that may be cured well if they are detected effectively and timely. Golgi protein is categorized into two parts cis-Golgi and trans-Golgi. The identification of Golgi protein via direct method is very hard due to limited available recognized structures...
May 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28758992/demystifying-traditional-herbal-medicine-with-modern-approach
#12
Fu-Shuang Li, Jing-Ke Weng
Plants have long been recognized for their therapeutic properties. For centuries, indigenous cultures around the world have used traditional herbal medicine to treat a myriad of maladies. By contrast, the rise of the modern pharmaceutical industry in the past century has been based on exploiting individual active compounds with precise modes of action. This surge has yielded highly effective drugs that are widely used in the clinic, including many plant natural products and analogues derived from these products, but has fallen short of delivering effective cures for complex human diseases with complicated causes, such as cancer, diabetes, autoimmune disorders and degenerative diseases...
July 31, 2017: Nature Plants
https://www.readbyqxmd.com/read/28758953/plant-virus-expression-vectors-a-powerhouse-for-global-health
#13
REVIEW
Kathleen Hefferon
Plant-made biopharmaceuticals have long been considered a promising technology for providing inexpensive and efficacious medicines for developing countries, as well as for combating pandemic infectious diseases and for use in personalized medicine. Plant virus expression vectors produce high levels of pharmaceutical proteins within a very short time period. Recently, plant viruses have been employed as nanoparticles for novel forms of cancer treatment. This review provides a glimpse into the development of plant virus expression systems both for pharmaceutical production as well as for immunotherapy...
July 30, 2017: Biomedicines
https://www.readbyqxmd.com/read/28755501/promoter-choice-impacts-the-efficiency-of-plant-glyco-engineering
#14
Somanath Kallolimath, Clemens Gruber, Herta Steinkellner, Alexandra Castilho
Glyco-modulation of therapeutic proteins produced in plants has shown great success. Plant-based expression platforms for tailored human-like N-glycosylation are based on the overexpression of foreign genes. However, drawbacks such as protein miss targeting, interference with endogenous glycosyltransferases or with plant development hamper the widespread use of the technology. Here we describe a technique that facilitates the generation of recombinant proteins with targeted N-glycosylation at high homogeneity...
July 29, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28755053/commentary-why-pharmaceutical-scientists-in-early-drug-discovery-are-critical-for-influencing-the-design-and-selection-of-optimal-drug-candidates
#15
Margaret S Landis, Shobha Bhattachar, Mehran Yazdanian, John Morrison
This commentary reflects the collective view of pharmaceutical scientists from four different organizations with extensive experience in the field of drug discovery support. Herein, engaging discussion is presented on the current and future approaches for the selection of the most optimal and developable drug candidates. Over the past two decades, developability assessment programs have been implemented with the intention of improving physicochemical and metabolic properties. However, the complexity of both new drug targets and non-traditional drug candidates provides continuing challenges for developing formulations for optimal drug delivery...
July 28, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28750894/patient-acceptability-of-3d-printed-medicines
#16
Alvaro Goyanes, Mariagiovanna Scarpa, Michael Kamlow, Simon Gaisford, Abdul W Basit, Mine Orlu
Patient-centric medicine is a derivative term for personalised medicine, whereby the pharmaceutical product provides the best overall benefit by meeting the comprehensive needs of the individual; considering the end-user from the beginning of the formulation design process right through development to an end product is a must. One way in which to obtain personalised medicines, on-site and on-demand is by three-dimensional printing (3DP). The aim of this study was to investigate the influence of the shape, size and colour of different placebo 3D printed tablets (Printlets™) manufactured by fused deposition modelling (FDM) 3DP on end-user acceptability regarding picking and swallowing...
July 24, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28747538/complexing-agents-and-ph-influence-on-chemical-durability-of-type-i-molded-glass-containers
#17
Alberto Biavati, Michele Poncini, Arianna Ferrarini, Nicola Favaro, Martina Scarpa, Marta Vallotto
Among the factors that affect the glass surface chemical durability, pH and complexing agents present in aqueous solution have the main role. Glass surface attack can be also related to the delamination issue causing glass particles' appearance in the pharmaceutical preparation. A few methods to check for glass containers delamination propensity and some control guidelines have been proposed. The present study emphasizes the possible synergy between a few complexing agents with pH on borosilicate glass chemical durability...
July 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/28745755/molecular-engineering-of-lanthanide-ion-chelating-phospholipids-generating-assemblies-with-a-switched-magnetic-susceptibility
#18
Stéphane Isabettini, Sarah Massabni, Arnel Hodzic, Dzana Durovic, Joachim Kohlbrecher, Takashi Ishikawa, Peter Fischer, Erich J Windhab, Peter Walde, Simon Kuster
Lanthanide ion (Ln(3+)) chelating amphiphiles are powerful molecules for tailoring the magnetic response of polymolecular assemblies. Mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 1,2-dimyristoyl-sn-glycero-3-phospho-ethanolamine-diethylene triaminepentaacetate (DMPE-DTPA) complexed to Ln(3+) deliver highly magnetically responsive bicelles. Their magnetic properties are readily tuned by changing the bicellar size or the magnetic susceptibility Δχ of the bilayer lipids. The former technique is intrinsically bound to the region of the phase diagram guarantying the formation of bicelles...
August 9, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28737935/the-current-state-of-peptide-drug-discovery-back-to-the-future
#19
Antoine Henninot, James C Collins, John M Nuss
Over the last decade, peptide drug discovery has experienced a revival of interest and scientific momentum, as the pharmaceutical industry has come to appreciate the role that peptide therapeutics can play in addressing unmet medical needs, and how this class of compounds can be an excellent complement or even preferable alternative to small molecule and biological therapeutics. In this perspective we give a concise description of the recent progress in peptide drug discovery in a holistic manner, highlighting enabling technological advances affecting nearly every aspect of this field: from lead discovery, to synthesis and optimization, to peptide drug delivery...
July 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28737444/evolving-patterns-in-a-collaboration-network-of-global-r-d-on-monoclonal-antibodies
#20
Xiangjun Kong, Jian-Bo Wan, Hao Hu, Shibing Su, Yuanjia Hu
We investigated the evolution process of collaborative inter-organizational network of the research and development (R&D) on monoclonal antibody (mAb) over the past 30 years. The annual detection of the collaboration network provides dynamics on network structures and relationship changes among different organizations. Our research showed continuous growth of the network's scale and complexity due to the constant entry of new organizations and the forging of new partnering relationships. The evolving topological features reveal a core-periphery structure that became clearer over time and an increasing heterogeneity within the collaborative mAb R&D network...
July 24, 2017: MAbs
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