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https://www.readbyqxmd.com/read/28319936/correction-fixed-dose-combination-of-ar-13324-and-latanoprost-a-double-masked-28-day-randomised-controlled-study-in-patients-with-open-angle-glaucoma-or-ocular-hypertension
#1
(no author information available yet)
No abstract text is available yet for this article.
July 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28315874/multiple-drug-hypersensitivity
#2
Werner J Pichler, Yuttana Srinoulprasert, James Yun, Oliver Hausmann
Multiple drug hypersensitivity (MDH) is a syndrome that develops as a consequence of massive T-cell stimulations and is characterized by long-lasting drug hypersensitivity reactions (DHR) to different drugs. The initial symptoms are mostly severe exanthems or drug rash with eosinophilia and systemic symptoms (DRESS). Subsequent symptoms due to another drug often appear in the following weeks, overlapping with the first DHR, or months to years later after resolution of the initial presentation. The second DHR includes exanthema, erythroderma, DRESS, Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), hepatitis, and agranulocytosis...
March 18, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28306595/update-on-maintenance-therapy-for-granulomatosis-with-polyangiitis-and-microscopic-polyangiitis
#3
Ora Singer, W Joseph McCune
PURPOSE OF REVIEW: The antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitides are a group of rare systemic diseases. The past several years have seen major therapeutic advances in the treatment of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). The success rate in induction of remission is high, but reducing the high incidence of relapses remains a therapeutic challenge. RECENT FINDINGS: Studies have shown no improvement in relapse rates in GPA and MPA over the past 2 decades...
March 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28303746/novel-design-and-optimisation-of-a-nitritation-anammox-setup-for-ammonium-removal-from-filtrate-of-digested-sludge
#4
Yury Nikolaev, Anna Kallistova, Marina Kevbrina, Alexander Dorofeev, Anton Agarev, Andrey Mardanov, Nikolay Ravin, Michail Kozlov, Nikolay Pimenov
Although anammox process is extensively applied to the treatment of high-strength ammonium wastewater, new technical solutions overcoming the operational difficulties remain an important task. In this study, an innovative design of anammox-based setup was employed to improve sludge settling under high ammonium load (up to 1000 mg NH4-N/l/d). The setup treated the filtrate of digested sludge and included a completely mixed constant flow bioreactor with suspended and immobilised activated sludge. Suspended sludge was recycled via a settler...
March 17, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28303056/fixed-dose-combination-of-alogliptin-pioglitazone-improves-glycemic-control-in-japanese-patients-with-type-2-diabetes-mellitus-independent-of-body-mass-index
#5
Chie Aoki, Kunihiro Suzuki, Hisamoto Kuroda, Masaaki Sagara, Masanori Shimizu, Kikuo Kasai, Yoshimasa Aso
This study investigated the effects of switching from combination therapy with either alogliptin (Alo) or pioglitazone (Pio) to fixed-dose combination therapy (FDCT) with alogliptin and pioglitazone (Alo-Pio FDCT). The usefulness and efficacy of Alo-Pio FDCT were investigated. A total of 50 outpatients with type 2 diabetes mellitus (T2DM) treated with Alo and 47 outpatients with T2DM treated with Pio were switched to Alo-Pio FDCT, and its efficacy and usefulness were evaluated. Significant improvements were observed in hemoglobinA1c (HbA1c), alanine transaminase (ALT), and γ-glutamyl transpeptidase (GGT) levels after switching to Alo-Pio FDCT for 16 weeks in both groups...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28300854/randomized-placebo-and-active-controlled-crossover-study-of-the-safety-and-efficacy-of-thvd-102-a-fixed-dose-combination-of-oxybutynin-and-pilocarpine-in-subjects-with-primary-focal-hyperhidrosis
#6
David M Pariser, Janakan Krishnaraja, Thomas M Tremblay, R Michael Rubison, Ted W Love, Benjamin F McGraw
BACKGROUND: While muscarinic antagonists (anticholinergics) have shown efficacy in treating primary focal hyperhidrosis (PFH), side effects - most commonly dry mouth - are intolerable for most patients. THVD-102, a fixed-dose combination product has been developed combining oxybutynin, a muscarinic antagonist, and pilocarpine, a muscarinic agonist. The pilocarpine is at a dose level and release profile optimized to correct salivary flow impaired by oxybutynin yet not interfere with the therapeutic muscarinic antagonist effect of oxybutynin upon the sweat glands...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28299716/fixed-dose-triple-combination-of-antihypertensive-drugs-improves-blood-pressure-control-from-clinical-trials-to-clinical-practice
#7
Alberto Mazza, Salvatore Lenti, Laura Schiavon, Antonella Paola Sacco, Fabio Dell'Avvocata, Gianluca Rigatelli, Emilio Ramazzina
INTRODUCTION: Blood pressure (BP) control is the main clinical goal in the management of hypertensive patients; however, BP in most of these patients remains uncontrolled, despite the widespread availability of antihypertensive drugs as free-combination therapy. This study compared the efficacy of a fixed-dose triple combination (FDTC) of antihypertensive drugs with that of a free combination of three antihypertensives in patients with uncontrolled hypertension. METHODS: Ninety-two patients (mean age 60...
March 15, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28298894/current-situation-of-medication-adherence-in-hypertension
#8
REVIEW
Bernard Vrijens, Sotiris Antoniou, Michel Burnier, Alejandro de la Sierra, Massimo Volpe
Despite increased awareness, poor adherence to treatments for chronic diseases remains a global problem. Adherence issues are common in patients taking antihypertensive therapy and associated with increased risks of coronary and cerebrovascular events. Whilst there has been a gradual trend toward improved control of hypertension, the number of patients with blood pressure values above goal has remained constant. This has both personal and economic consequences. Medication adherence is a multifaceted issue and consists of three components: initiation, implementation, and persistence...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28298261/efficacy-and-safety-of-agomelatine-10-or-25-mg-day-in-non-depressed-out-patients-with-generalized-anxiety-disorder-a-12-week-double-blind-placebo-controlled-study
#9
Dan J Stein, Antti Ahokas, Marek Jarema, Alla S Avedisova, Livia Vavrusova, Oleg Chaban, Céline Gruget, Valérie Olivier, Françoise Picarel-Blanchot, Christian de Bodinat
Agomelatine is efficacious in reducing symptoms and preventing relapse in placebo-controlled trials in generalised anxiety disorder (GAD). Nevertheless, fixed dose studies of agomelatine in GAD have not been undertaken. To determine the minimally effective optimal dose of agomelatine in GAD, the efficacy of two doses of agomelatine (10 and 25mg/day) was investigated in a 12-week, placebo-controlled, double-blind, international study in patients with a primary diagnosis of GAD. The primary outcome measure was the Hamilton Anxiety scale (HAM-A)...
March 12, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28297450/dosimetric-comparison-between-cone-iris-based-and-incise-mlc-based-cyberknife-plans-for-single-and-multiple-brain-metastases
#10
Si Young Jang, Ron Lalonde, Cihat Ozhasoglu, Steven Burton, Dwight Heron, M Saiful Huq
We performed an evaluation of the CyberKnife InCise MLC by comparing plan qualities for single and multiple brain lesions generated using the first version of InCise MLC, fixed cone, and Iris collimators. We also investigated differences in delivery efficiency among the three collimators. Twenty-four patients with single or multiple brain mets treated previously in our clinic on a CyberKnife M6 using cone/Iris collimators were selected for this study. Treatment plans were generated for all lesions using the InCise MLC...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297441/comprehensive-dosimetric-planning-comparison-for-early-stage-non-small-cell-lung-cancer-with-sabr-fixed-beam-imrt-versus-vmat-versus-tomotherapy
#11
Ilma Xhaferllari, Omar El-Sherif, Stewart Gaede
Volumetric-modulated arc therapy (VMAT) is emerging as a leading technology in treating early-stage, non-small cell lung cancer (NSCLC) with stereotactic ablative radiotherapy (SABR). However, two other modalities capable of delivering intensity-modulated radiation therapy (IMRT) include fixed-beam and helical TomoTherapy (HT). This study aims to provide an extensive dosimetric comparison among these various IMRT techniques for treating early-stage NSCLC with SABR. Ten early-stage NSCLC patients were retrospectively optimized using three fixed-beam techniques via nine to eleven beams (high and low modulation step-and-shoot (SS), and sliding window (SW)), two VMAT techniques via two partial arcs (SmartArc (SA) and RapidArc (RA)), and three HT techniques via three different fan beam widths (1 cm, 2...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297427/a-comparative-study-of-identical-vmat-plans-with-and-without-jaw-tracking-technique
#12
Hao Wu, Fan Jiang, Haizhen Yue, Qiaoqiao Hu, Jian Zhang, Zhuolun Liu, Jian Gong, Sha Li, Jianhao Geng, Yibao Zhang
The unwanted radiation transmission through the multileaf collimators could be reduced by the jaw tracking technique which is commercially available on Varian TrueBeam accelerators. On the basis of identical plans, this study aims to investigate the dosimetric impact of jaw tracking on the volumetric-modulated arc therapy (VMAT) plans. Using Eclipse treatment planning system (TPS), 40 jaw-tracking VMAT plans with various tumor volumes and shapes were optimized. Fixed jaw plans were created by editing the jaw coordinates of the jaw-tracking plans while other parameters were identical...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297350/impact-of-small-mu-segment-and-dose-rate-on-delivery-accuracy-of-volumetric-modulated-arc-therapy-vmat
#13
Long Huang, Tingliang Zhuang, Anthony Mastroianni, Toufik Djemil, Taoran Cui, Ping Xia
Volumetric-modulated arc therapy (VMAT) plans may require more control points (or segments) than some of fixed-beam IMRT plans that are created with a limited number of segments. Increasing number of control points in a VMAT plan for a given prescription dose could create a large portion of the total number of segments with small number monitor units (MUs) per segment. The purpose of this study is to investigate the impact of the small number MU/segment on the delivery accuracy of VMAT delivered with various dose rates...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297328/a-preplanning-method-for-stereotactic-radiosurgery-to-improve-treatment-workflow
#14
Kang-Hyun Ahn, Naim Ozturk, Brett Smith, Konstantin V Slavin, Matthew Koshy, Bulent Aydogan
Frame-based stereotactic radiosurgery (SRS) requires fixation of an invasive head ring to ensure accurate targeting. Minimizing waiting time with a fixed head ring is important for patient comfort and satisfaction. We report a practical preplanning solution for the Brainlab iPlan treatment planning system that reduces waiting time by expediting the planning process on treatment day. A water-filled anthropomorphic head phantom was used to acquire a surrogate CT image set for preplanning and fused with patient's MRI, which was obtained before the day of treatment...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297276/rounded-leaf-end-modeling-in-pinnacle-vmat-treatment-planning-for-fixed-jaw-linacs
#15
Lori A Young, Fei Yang, Ning Cao, Juergen Meyer
During volume-modulated arc therapies (VMAT), dosimetric errors are introduced by multiple open dynamic leaf gaps that are present in fixed diaphragm linear accelerators. The purpose of this work was to develop a methodology for adjusting the rounded leaf end modeling parameters to improve out-of-field dose agreement in SmartArc VMAT treatment plans delivered by fixed jaw linacs where leaf gap dose is not negligible. Leaf gap doses were measured for an Elekta beam modulator linac with 0.4 cm micro-multileaf collimators (MLC) using an A16 micro-ionization chamber, a MatriXX ion chamber detector array, and Kodak EDR2 film dosimetry in a solid water phantom...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296327/fricke-gel-dosimeter-with-improved-sensitivity-for-low-dose-level-measurements
#16
Mauro Vaiente, Wladimir Molina, Lila Carrizales Silva, Rodolfo Figueroa, Francisco Malano, Pedro Pérez, Mauricio Santibañez, José Vedelago
Fricke solution has a wide range of applications as radiation detector and dosimetry. It is particularly appreciated in terms of relevant comparative advantages, like tissue-equivalence when prepared in aqueous media like gel matrix, continuous mapping capability, independence of dose rate and incident direction, as well as linear dose response. This work presents the development and characterization of an improved Fricke gel system, based on modified chemical compositions, making possible its application in clinical radiology due to its improved sensitivity...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295513/toxicity-dependent-feasibility-bounds-for-the-escalation-with-overdose-control-approach-in-phase-i-cancer-trials
#17
Graham M Wheeler, Michael J Sweeting, Adrian P Mander
Phase I trials of anti-cancer therapies aim to identify a maximum tolerated dose (MTD), defined as the dose that causes unacceptable toxicity in a target proportion of patients. Both rule-based and model-based methods have been proposed for MTD recommendation. The escalation with overdose control (EWOC) approach is a model-based design where the dose assigned to the next patient is one that, given all available data, has a posterior probability of exceeding the MTD equal to a pre-specified value known as the feasibility bound...
March 15, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28295385/technical-note-the-design-and-function-of-a-horizontal-patient-rotation-system-for-the-purposes-of-fixed-beam-cancer-radiotherapy
#18
Ilana Feain, Lloyd Coleman, Hue Wallis, Richard Sokolov, Ricky O'Brien, Paul Keall
PURPOSE: Cancer radiation therapy treatment is performed by delivering a 3D dose distribution to the tumour via the relative rotation between beam and patient. Whilst most modern machines rotate the radiation beam around a still patient, the treatment can also be delivered by rotating the patient relative to a fixed beam. Fixed-beam, patient rotation radiotherapy machines show promise for reducing the size, surface area footprint, and shielding requirements compared with rotating gantry machines...
March 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/28293928/efficacy-of-sublingual-immunotherapy-for-house-dust-mite-induced-allergic-rhinitis-a-meta-analysis-of-randomized-controlled-trials
#19
Bohai Feng, Haijie Xiang, Haiyong Jin, Jinjian Gao, Saiyu Huang, Yunbin Shi, Ruru Chen, Bobei Chen
PURPOSE: Allergic rhinitis (AR) has become a global issue for a large part of the general population. Sublingual immunotherapy (SLIT) has been used extensively to treat persistent allergic rhinitis (PAR). Although systematic reviews have confirmed the effectiveness of SLIT for the treatment of AR, a considerable number of studies using extracts of house dust mites (HDMs) for immunotherapy found no consensus on basic treatment parameters and questioned the efficacy of SLIT. METHODS: In this study, we evaluated SLIT for PAR by a meta-analysis of randomized controlled trials (RCTs)...
May 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28293046/efficacy-of-risperidone-augmentation-with-ondansetron-in-the-treatment-of-negative-and-depressive-symptoms-in-schizophrenia-a-randomized-clinical-trial
#20
Roya Samadi, Susan Soluti, Reza Daneshmand, Shervin Assari, Ali Akhoundpour Manteghi
BACKGROUND: Given the potential role of the 5-hydroxytryptamine-3 receptor in the pathogenesis of schizophrenia, this study was performed to determine whether ondansetron plus risperidone could reduce the negative and depressive symptoms in patients with treatment-resistant schizophrenia. METHODS: In a double-blinded, placebo-controlled, randomized trial (IRCT registration # 201112125280N7), in 2012-2013 in Mashhad, Iran, 38 patients with treatment-resistant schizophrenia received risperidone either combined with a fixed dose (4-8 mg/d) of ondansetron (n=18) or with a placebo (n=20) for 12 weeks...
January 2017: Iranian Journal of Medical Sciences
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