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https://www.readbyqxmd.com/read/29588171/mechanism-of-adrenomedullin-2-intermedin-mediated-vasorelaxation-in-rat-main-pulmonary-artery
#1
Gokcen Telli, Yasemin Erac, Banu Cahide Tel, Bulent Gumusel
Adrenomedullin 2/intermedin (AM2/IMD) is a member of calcitonin related gene peptide family and an important nitric oxide mediated vasorelaxant in various vascular beds. However, the mechanism of post receptor-interaction is not clear and may differ depending on tissue type and species. In this study, we aimed to investigate the exact mechanism and the role of BKCa and calcium channels on the vasorelaxant effect of AM2/IMD in rat PA. Changes in the AM2/IMD-mediated vasorelaxation were evaluated in the presence of various inhibitors...
March 24, 2018: Peptides
https://www.readbyqxmd.com/read/29563999/intermedin-promotes-hepatocellular-carcinoma-cell-proliferation-through-the-classical-wnt-signaling-pathway
#2
Hai Shang, Zhi Qiang Hao, Xi Bo Fu, Xiang Dong Hua, Zuo Hong Ma, Fu Lu Ai, Zhao Qiang Feng, Kun Wang, Wen Xin Li, Bo Li
The proliferative activity of hepatic carcinoma cells is directly associated with tumorigenesis, tumor development, metastasis and invasion. A variety of cytokines and peptides serve important roles in the development of hepatic carcinoma. The aim of the present study was to examine the effect of intermedin (IMD) on hepatic carcinoma cell proliferation and its mechanism of action. HepG2 hepatic carcinoma cell lines were treated with human recombinant IMD1-53 and its receptor antagonist IMD17-47. Cell proliferation was detected using a Cell Counting kit-8...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29525674/in-renal-hypertension-cirsium-japonicum-strengthens-cardiac-function-via-the-intermedin-nitric-oxide-pathway
#3
Xiaoling Yang, Hui Shao, Yong Chen, Ning Ding, Anning Yang, Jue Tian, Yuanxu Jiang, Guizhong Li, Yideng Jiang
Cirsium japonicum, a constituent of traditional Chinese medicine, has been shown to exert inflammatory effects as well as to improve the circulation and thus to counteract hematologic stasis. Studies have demonstrated that intermedin (IMD) has protective effects on hypertension in rats by regulating the Ang/NO metabolic pathway. In this study, we investigated whether by regulating the expression of IMD, Cirsium japonicum could improve cardiac function in rats with 2k1c-induced renal hypertension. Renal hypertension was induced in Sprague-Dawley rats by occluding the renal artery...
March 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29501724/%C3%AE-cgrp-another-amyloidogenic-member-of-the-cgrp-family
#4
Paraskevi L Tsiolaki, Georgia I Nasi, Fotis A Baltoumas, Nikolaos N Louros, Vassiliki Magafa, Stavros J Hamodrakas, Vassiliki A Iconomidou
The Calcitonin-gene related peptide (CGRP) family is a group of peptide hormones, which consists of IAPP, calcitonin, adrenomedullin, intermedin, αCGRP and βCGRP. IAPP and calcitonin have been extensively associated with the formation of amyloid fibrils, causing Type 2 Diabetes and Medullary Thyroid Carcinoma, respectively. In contrast, the potential amyloidogenic properties of αCGRP still remain unexplored, although experimental trials have indicated its presence in deposits, associated with the aforementioned disorders...
March 1, 2018: Journal of Structural Biology
https://www.readbyqxmd.com/read/29242270/intermedin-enlarges-the-vascular-lumen-by-inducing-the-quiescent-endothelial-cell-proliferation
#5
Li-Jun Wang, Fei Xiao, Ling-Miao Kong, De-Nian Wang, Hong-Yu Li, Yong-Gang Wei, Chun Tan, Huan Zhao, Ting Zhang, Gui-Qun Cao, Kang Zhang, Yu-Quan Wei, Han-Shuo Yang, Wei Zhang
OBJECTIVE: Intermedin plays an important role in vascular remodeling and significantly improves blood perfusion, but the precise mechanism remains unclear. Herein, we aimed to define whether vascular lumen enlargement is responsible for the intermedin-increased blood perfusion and explore the underlying cellular and molecular mechanisms. APPROACH AND RESULTS: To study the role of intermedin, we generated the IMD-KO ( Adm2 -/- ) mice using CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeat-associated 9) system...
February 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29162436/effect-of-intermedin-adrenomedullin-2-on-the-pulmonary-vascular-bed-in-hypoxia-induced-pulmonary-hypertensive-rats
#6
Gokcen Telli, Banu Cahide Tel, Nilgun Yersal, Petek Korkusuz, Bulent Gumusel
AIMS: This study aimed to investigate the effect and mechanism of action of intermedin/adrenomedullin2 (IMD/AM2 ) on the pulmonary vascular bed in pulmonary hypertensive rats. MATERIALS AND METHODS: Male Sprague-Dawley rats were exposed to hypobaric hypoxia for 3 weeks to induce pulmonary hypertension (PHT). The development of PHT was confirmed by histopathological analyses and measurement of hematocrit, basal perfusion pressure, and right ventricle hypertrophy...
January 1, 2018: Life Sciences
https://www.readbyqxmd.com/read/29146892/intermedin-ameliorates-atherosclerosis-by-increasing-cholesterol-efflux-through-the-camp-pka-pathway-in-macrophage-raw264-7-cell-line
#7
Hang Liao, Shixi Wan, Xin Zhang, Di Shi, Xiaojiang Zhu, Xiaoping Chen
BACKGROUND The aim of this study was to explore the role of intermedin and its mechanism in cholesterol efflux of macrophage THP-1 and RAW264.7 cell lines in atherosclerosis (AS). MATERIAL AND METHODS ApoE-/- mice were fed with a high-fat diet, and the concentrations of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured. The lipidoses of the aortic sinus were analyzed by hematoxylin and eosin staining, and the cAMP level was detected by enzyme-linked immunosorbent assay (ELISA)...
November 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29128104/effects-of-intermedin-on-autophagy-in-cerebral-ischemia-reperfusion-injury
#8
Meng Wang, Jing Wang, Zhengang Liu, Xin Guo, Ning Wang, Nana Jia, Yanshu Zhang, Jie Yuan
OBJECTIVE: This study aimed to evaluate the effects of intermedin (IMD) on autophagy in cerebral ischemia/reperfusion (I/R) injury (CIRI). METHODS: Sixty rats were randomly averaged into four groups: sham, ischemia/reperfusion (I/R), IMD, and 3-methyladenine (3-MA). In the sham group, the right common carotid artery, external carotid artery, and internal carotid artery were detached, and no monofilament was inserted. In the other groups, two hours after cerebral ischemia, the rats were injected through the lateral ventricle with normal saline for I/R group, IMD for the IMD group, and 3-MA for the 3-MA group for 24h...
November 8, 2017: Neuropeptides
https://www.readbyqxmd.com/read/29059473/update-on-the-pharmacology-of-calcitonin-cgrp-family-of-peptides-iuphar-review-25
#9
REVIEW
Debbie L Hay, Michael L Garelja, David R Poyner, Christopher S Walker
The calcitonin/CGRP family of peptides includes calcitonin, α and β CGRP, amylin, adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist of one of two GPCRs, the calcitonin receptor (CTR) or the calcitonin receptor-like receptor (CLR). Further diversity arises from heterodimerization of these GPCRs with one of three receptor activity-modifying proteins (RAMPs). This gives the CGRP receptor (CLR/RAMP1), the AM1 and AM2 receptors (CLR/RAMP2 or RAMP3) and the AMY1, AMY2 and AMY3 receptors (CTR/RAMPs1-3 complexes, respectively)...
January 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29053988/intermedin-reduces-neointima-formation-by-regulating-vascular-smooth-muscle-cell-phenotype-via-camp-pka-pathway
#10
Qing Zhu, Xian-Qiang Ni, Wei-Wei Lu, Jin-Sheng Zhang, Jin-Ling Ren, Di Wu, Yao Chen, Lin-Shuang Zhang, Yan-Rong Yu, Chao-Shu Tang, Yong-Fen Qi
BACKGROUND AND AIMS: Vascular smooth muscle cell (VSMC) dedifferentiation contributes to neointima formation, which results in various vascular disorders. Intermedin (IMD), a cardiovascular paracrine/autocrine polypeptide, is involved in maintaining circulatory homeostasis. However, whether IMD protects against neointima formation remains largely unknown. The purpose of this study is to investigate the role of IMD in neointima formation and the possible mechanism. METHODS: IMD1-53 (100ng/kg/h) or saline water was used on rat carotid-artery balloon-injury model...
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28805491/intermedin-inhibits-unilateral-ureteral-obstruction-induced-oxidative-stress-via-nadph-oxidase-nox4-and-camp-dependent-mechanisms
#11
Xi Qiao, Lihua Wang, Yanhong Wang, Xiaole Su, Yue Qi, Yun Fan, Zhiqiang Peng
NADPH oxidase Nox4-derived reactive oxygen species (ROS) play important roles in renal fibrosis. Our previous study demonstrated that intermedin (IMD) alleviated unilateral ureteral obstruction (UUO)-induced renal fibrosis by inhibition of ROS. However, the precise mechanisms remain unclear. Herein, we investigated the effect of IMD on Nox4 expression and NADPH oxidase activity in rat UUO model, and explored if these effect were achieved through cAMP-PKA pathway, the important post-receptor signal transduction pathway of IMD, in TGF-β1-stimulated rat proximal tubular cell (NRK-52E)...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28795663/-evaluation-function-of-intermedin-on-prognosis-of-elderly-patients-with-sepsis
#12
Yi Zhang, Fengxue Zhu, Weihuan Du, Yongmei He, Li Guo, Zhihong Yan, Hong Ji
OBJECTIVE: To investigate the predicting value of intermedin (IMD) for the prognosis of elderly sepsis patients. METHODS: A retrospective analysis was conducted. Forty-one patients with sepsis, aged ≥65 years, and admitted to geriatrics intensive care unit of Aerospace Center Hospital from April 2015 to December 2016 were enrolled. Thirty healthy patients were studied as control during the same time. The expression of C-reactive protein (CRP), procalcitonin (PCT) and IMD were tested within 24 hours during hospitalization, and the acute physiology and chronic health evaluation II (APACHE II) score and prognosis was evaluated...
August 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28697727/intermedin-attenuates-renal-fibrosis-by-induction-of-heme-oxygenase-1-in-rats-with-unilateral-ureteral-obstruction
#13
Xi Qiao, Lihua Wang, Yanhong Wang, Xiaole Su, Yufeng Qiao, Yun Fan, Zhiqiang Peng
BACKGROUND: Intermedin [IMD, adrenomedullin-2 (ADM-2)] attenuates renal fibrosis by inhibition of oxidative stress. However, the precise mechanisms remain unknown. Heme oxygenase-1 (HO-1), an antioxidant agent, is associated with antifibrogenic effects. ADM is known to induce HO-1. Whether IMD has any effect on HO-1 is unclear. Herein, we determined whether the antifibrotic properties of IMD are mediated by induction of HO-1. METHODS: Renal fibrosis was induced by unilateral ureteral obstruction (UUO) performed on male Wistar rats...
July 11, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28627670/intermedin-improves-cardiac-function-and-sympathetic-neural-remodeling-in-a-rat-model-of-post-myocardial-infarction-heart-failure
#14
Bin Xu, Hao Xu, Heng Cao, Xiaoxiao Liu, Chunhuan Qin, Yanzhou Zhao, Xiaolin Han, Hongli Li
Emerging evidence has suggested that intermedin (IMD), a novel member of the calcitonin gene‑related peptide (CGRP) family, has a wide range of cardioprotective effects. The present study investigated the effects of long‑term administration of IMD on cardiac function and sympathetic neural remodeling in heart failure (HF) rats, and studied potential underlying mechanism. HF was induced in rats by myocardial infarction (MI). Male Sprague Dawley rats were randomly assigned to either saline or IMD (0.6 µg/kg/h) treatment groups for 4 weeks post‑MI...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28417590/calcitonin-gene-related-peptide-cgrp-a-novel-target-for-alzheimer-s-disease
#15
REVIEW
Yogendra Singh, Gaurav Gupta, Birendra Shrivastava, Rajiv Dahiya, Juhi Tiwari, Madhu Ashwathanarayana, Rakesh Kumar Sharma, Mohit Agrawal, Anurag Mishra, Kamal Dua
Alzheimer's disease (AD) is leading cause of death among older characterized by neurofibrillary tangles, oxidative stress, progressive neuronal deficits, and increased levels of amyloid-β (Aβ) peptides. Cholinergic treatment could be the best suitable physiological therapy for AD. Calcitonin gene-related peptide (CGRP) is a thirty-seven-amino acid regulatory neuropeptide resulting from different merging of the CGRP gene, which also includes adrenomedullin, amylin, calcitonin, intermedin, and calcitonin receptor-stimulating peptide...
June 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28413495/perioperative-application-of-salvianolate-on-oxidative-stress-and-plasma-imd-adm2-in-patients-with-acute-myocardial-infarction-undergoing-pci
#16
Qiang Zhang, Fengjun Jiao, Chongjun Hua
The present study was conducted to investigate the effects of salvianolate on perioperative oxidative stress and plasma Intermedin/adrenomedullin 2 (IMD/ADM2) in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). The clinical data of 108 patients with AMI treated by PCI were retrospectively analyzed. According to the use of salvianolate in perioperative period, the patients were divided into the study group (n=62) and the control group (n=46). The control group was given routine treatment while the study group was given routine treatment combined with intravenous infusion of salvianolate (200 mg administered once at 24 h before operation, once/day after operation, 1 week later, the curative effect was observed)...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28407200/adrenomedullin-2-intermedin-a-putative-drug-candidate-for-treatment-of-cardiometabolic-diseases
#17
REVIEW
Song-Yang Zhang, Ming-Jiang Xu, Xian Wang
Adrenomedullin (ADM) 2/Intermedin (IMD) is a short peptide that belongs to the CGRP superfamily. Although it shares receptors with CGRP, ADM and amylin (AMY), ADM2 has significant and unique functions in the cardiovascular system. In the past decade, the cardiovascular effect of ADM2 has carefully been studied. In this review, progress in understanding ADM2's effects on the cardiovascular system as well as its protective role in cardiometabolic diseases are summarized.
April 13, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28259938/intermedin1%C3%A2-53-enhances-angiogenesis-and-attenuates-adverse-remodeling-following-myocardial-infarction-by-activating-amp%C3%A2-activated-protein-kinase
#18
Kankai Chen, Meiling Yan, Yongguang Li, Zhifeng Dong, Dong Huang, Jingbo Li, Meng Wei
Adverse ventricular remodeling is a maladaptive response to acute loss of myocardium and an important risk factor for heart failure following myocardial infarction (MI). Intermedin (IMD) is a novel member of the calcitonin/calcitonin gene‑related peptide family, which may possess potent cardioprotective properties. The aim of the present study was to determine whether IMD1‑53, a mature bioactive form of IMD, may promote therapeutic angiogenesis within the infarcted myocardium, therefore attenuating adverse ventricular remodeling post‑MI...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28065931/intermedin-1-53-inhibits-myocardial-fibrosis-in-rats-by-down-regulating-transforming-growth-factor-%C3%AE
#19
Jian Fang, Jiangwei Luan, Gaohong Zhu, Chang Qi, Zhiyong Yang, Sheng Zhao, Bin Li, Xinzhong Zhang, Naipeng Guo, Xiaodong Li, Dandan Wang
BACKGROUND Myocardial fibrosis is the result of persistent anoxia and ischemic myocardial fibers caused by coronary atherosclerotic stenosis, which lead to heart failure, threatening the patient's life. This study aimed to explore the regulatory role of intermedin 1-53 (IMD1-53) in cardiac fibrosis using neonatal rat cardiac fibroblasts and a myocardial infarction (MI) rat model both in vitro and in vivo. MATERIAL AND METHODS The Western blot method was used to detect the protein expression of collagen I and collagen III in myocardial fibroblasts...
January 9, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28057159/-the-effect-and-mechanism-investigation-of-intermedin-on-the-apoptosis-of-bone-marrow-derived-mesenchymal-stem-cells-induced-by-hydrogen-peroxide
#20
D M Wang, J Li, W M Chen, X P Long, B Shi, R Z Zhao
Objective: To investigate the effect and mechanism of intermedin (IMD)on the apoptosis of BMSCs induced by H2O2 and its mechanism. Methods: BMSCs being cultured in vitro. After 30 min pretreatment with 10(-6)mol/L IMD, cells were cultured in presence of 100 μmol/L H2O2 for 2 hour, cell apoptosis was determined by flow cytometry; Apoptosis related protein expression was determined by Western blotting and immunofluorescence; Protein and phosphorylation of ERK1/2 was detected by Western blotting and observe the influence of IMD after pretreatment with inhibitor of ERK1/2...
December 27, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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