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central nervous system germ cell tumors

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https://www.readbyqxmd.com/read/27824869/maternal-smoking-and-the-risk-of-cancer-in-early-life-a-meta-analysis
#1
Isabell Katharina Rumrich, Matti Viluksela, Kirsi Vähäkangas, Mika Gissler, Heljä-Marja Surcel, Otto Hänninen
BACKGROUND: In spite of the well-known harmful effects on the fetus, many women continue smoking during pregnancy. Smoking as an important source of toxic chemicals may contribute to the developmental origin of diseases. OBJECTIVES: The aim of this work was to pursue the possible association between maternal smoking and cancer in early life. Specifically, we wanted to identify the associated early life cancer types, and to quantify the associations. METHODS: In a systematic literature search 825 articles were identified in PubMed and Web of Science, and 55 more through the reference lists...
2016: PloS One
https://www.readbyqxmd.com/read/27768709/maternal-and-birth-characteristics-and-childhood-embryonal-solid-tumors-a-population-based-report-from-brazil
#2
Neimar de Paula Silva, Rejane de Souza Reis, Rafael Garcia Cunha, Júlio Fernando Pinto Oliveira, Marceli de Oliveira Santos, Maria S Pombo-de-Oliveira, Beatriz de Camargo
BACKGROUND: Several maternal and birth characteristics have been reported to be associated with an increased risk of many childhood cancers. Our goal was to evaluate the risk of childhood embryonal solid tumors in relation to pre- and perinatal characteristics. METHODS: A case-cohort study was performed using two population-based datasets, which were linked through R software. Tumors were classified as central nervous system (CNS) or non-CNS-embryonal (retinoblastoma, neuroblastoma, renal tumors, germ cell tumors, hepatoblastoma and soft tissue sarcoma)...
2016: PloS One
https://www.readbyqxmd.com/read/27566974/the-clinical-presentation-and-favorable-prognosis-of-patients-with-isolated-metachronous-brain-metastasis-from-germ-cell-tumors
#3
Takashi Kawahara, Koji Kawai, Takayuki Yoshino, Atsushi Ikeda, Ryutarou Ishizuka, Shuya Kandori, Ei-Ichirou Takaoka, Takahiro Kojima, Akira Joraku, Takahiro Suetomi, Jun Miyazaki, Hiroyuki Nishiyama
OBJECTIVE: We conducted the present study to elucidate the clinical presentation, treatment outcomes and risk factors for the development of metachronous brain metastasis at a single progressive disease site, the so-called isolated brain metastasis, in patients with testicular germ cell tumors. METHODS: To identify metachronous brain metastasis in a timely manner, brain imaging was performed when the re-elevation of tumor markers was observed during chemotherapy, even in patients who were free from central nervous system symptoms...
August 27, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27554756/pediatric-malignant-germ-cell-tumors-a-comparison-of-the-neuro-oncology-and-solid-tumor-experience
#4
Ashley S Plant, Susan N Chi, Lindsay Frazier
Malignant germ cell tumors (GCT) arise from abnormal migration of primordial germ cells and are histologically identical whether they occur inside or outside the central nervous system (CNS). However, the treatment strategy for GCTs varies greatly depending on the location of the tumor. These differences are in part due to the increased morbidity of surgery in the CNS but may also reflect differential sensitivity of the tumors to chemotherapy and radiation therapy (RT) or not-yet-understood biologic differences between these tumors...
August 24, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27554477/nationwide-population-based-incidence-and-survival-rates-of-malignant-central-nervous-system-germ-cell-tumors-in-korea-2005-2012
#5
Seung Hoon Lee, Kyu-Won Jung, Johyun Ha, Chang-Mo Oh, Hyeseon Kim, Hyeon Jin Park, Heon Yoo, Young-Joo Won
Purpose: Malignant CNS germ cell tumors (GCTs), although rare, are thought to occur more frequently among Asians. However, a recent population-based study revealed no differences in GCT incidence between Asians and Caucasians. Therefore, this study was conducted to determine the incidence and survival rates of CNS GCTs using the National Korea Cancer Registry, and to compare these rates to those in the United States and Japan. Materials and Methods: We extracted CNS GCT patients diagnosed between 2005 and 2012 from the Korean Central Cancer Registry database...
August 24, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27517468/population-mixing-and-incidence-of-cancers-in-adolescents-and-young-adults-between-1990-and-2013-in-yorkshire-uk
#6
A Imam, L Fairley, R C Parslow, R G Feltbower
PURPOSE: Epidemiological evidence suggests a role for an infectious etiology for cancers in teenagers and young adults (TYAs). We investigated this by describing associations between infection transmission using the population mixing (PM) proxy and incidence of cancers in TYAs in Yorkshire, UK. METHODS: We extracted cancer cases from the Yorkshire Specialist Register of Cancer in Children and Young People from 1990 to 2013 (n = 1929). Using multivariable Poisson regression models (adjusting for effects of deprivation and population density), we investigated whether PM was associated with cancer incidence...
October 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27476038/intracranial-germ-cell-tumors-a-multi-institutional-experience-from-three-tertiary-care-centers-in-india
#7
Aanchal Kakkar, Ahitgani Biswas, Nikhil Kalyani, Uttara Chatterjee, Vaishali Suri, Mehar C Sharma, Nishant Goyal, Bhawani S Sharma, Supriya Mallick, Pramod K Julka, Girish Chinnaswamy, Brijesh Arora, Epari Sridhar, Sandip Chatterjee, Rakesh Jalali, Chitra Sarkar
OBJECTIVE: Central nervous system germ cell tumors (CNS GCTs) are relatively rare neoplasms. Incidence of CNS GCTs in Western literature is low (0.3-0.6 %) as compared to East Asia (3-4 %). No large study is available on CNS GCTs from India. METHODS: Intracranial GCT cases were retrieved from databases of three tertiary care institutes in India; clinicopathological data was reviewed. RESULTS: Ninety-five intracranial GCT cases were identified, accounting for 0...
July 30, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27406584/utility-of-mri-versus-tumor-markers-for-post-treatment-surveillance-of-marker-positive-cns-germ-cell-tumors
#8
Victoria Cheung, Devorah Segal, Sharon L Gardner, David Zagzag, Jeffrey H Wisoff, Jeffrey C Allen, Matthias A Karajannis
Patients with marker-positive central nervous system (CNS) germ cell tumors are typically monitored for tumor recurrence with both tumor markers (AFP and b-hCG) and MRI. We hypothesize that the recurrence of these tumors will always be accompanied by an elevation in tumor markers, and that surveillance MRI may not be necessary. We retrospectively identified 28 patients with CNS germ cell tumors treated at our institution that presented with an elevated serum or cerebrospinal fluid (CSF) tumor marker at the time of diagnosis...
September 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27312077/psychiatric-manifestations-as-initial-presentation-for-pediatric-cns-germ-cell-tumors-a-case-series
#9
F Malbari, T R Gershon, J H Garvin, J C Allen, Y Khakoo, A S Levy, I J Dunkel
BACKGROUND: Central nervous system (CNS) germ cell tumors account for 3 % of all pediatric brain tumors in the USA. Presenting symptoms are typically location based with pineal tumors presenting with obstructive hydrocephalus and suprasellar tumors with hypothalamic/pituitary dysfunction and ophthalmologic abnormalities. Psychiatric manifestations such as psychosis and behavioral changes are atypical presentations of CNS germ cell tumors, with only 11 previously reported cases. METHODS: This is a retrospective case series describing patients with CNS germ cell tumors with an atypical presentation including psychiatric manifestations...
August 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27239400/re-irradiation-of-recurrent-pineal-germ-cell-tumors-with-radiosurgery-report-of-two-cases-and-review-of-literature
#10
REVIEW
Kenneth Wong, Anthony B Opimo, Arthur J Olch, Sean All, Jonathan F Waxer, Desirae Clark, Justine Cheng, Alisha Chlebik, Anat Erdreich-Epstein, Mark D Krieger, Benita Tamrazi, Girish Dhall, Jonathan L Finlay, Eric L Chang
Primary intracranial germ cell tumors are rare, representing less than 5% of all central nervous system tumors. Overall, the majority of germ cell tumors are germinomas and approximately one-third are non-germinomatous germ cell tumors (NGGCT), which include teratoma, embryonal carcinoma, yolk sac tumor (endodermal sinus tumor), choriocarcinoma, or mixed malignant germ cell tumor. Germ cell tumors may secrete detectable levels of proteins into the blood and/or cerebrospinal fluid, and these proteins can be used for diagnostic purposes or to monitor tumor recurrence...
April 25, 2016: Curēus
https://www.readbyqxmd.com/read/27169016/development-of-cns-type-primitive-neuroectodermal-tumor-in-metastatic-testicular-mixed-germ-cell-tumor
#11
Anobel Y Odisho, Joseph T Rabban, Maxwell V Meng
A 29-year-old man presenting with a retroperitoneal mass was found to have a testis lesion consistent with mixed germ cell tumor and the RPLND specimen showed teratoma with an area of central nervous system-type primitive neuroectodermal tumor (PNET) not present in the testis. Whether such primitive tumor components represent a de novo tumor component or represent progression from existing neuroepithelial teratomatous elements is unclear. Given the high likelihood of residual tumor and possibility of malignant transformation, post-chemotherapy RPLND remains vital in treating patients with testis cancer...
May 2016: Urology Case Reports
https://www.readbyqxmd.com/read/27123048/expression-and-mutation-of-c-kit-in-intracranial-germ-cell-tumors-a-single-centre-retrospective-study-of-30-cases-in-china
#12
Yu-Ping Gao, Ji-Yao Jiang, Qiang Liu
Although primary central nervous system (CNS) germ cell tumors (GCTs) are one of the most treatable types of malignant brain tumor, a subset of patients remain resistant to standard chemotherapy. Gain-of-function mutations of the c-Kit gene, and KIT protein expression, have been observed in a number of GCTs, including testicular seminoma, ovarian dysgerminoma and mediastinal seminoma in various ethnic groups. Although a small number of studies have reported the role of c-Kit in CNS GCTs, few have focused on Chinese patients exhibiting CNS GCTs...
May 2016: Oncology Letters
https://www.readbyqxmd.com/read/27093073/neonatal-solid-tumors-incidence-and-survival-in-france
#13
Emmanuel Desandes, Sandra Guissou, Stéphane Ducassou, Brigitte Lacour
BACKGROUND: Solid tumors are uncommon in the neonatal period but represent an important cause of mortality and morbidity. PROCEDURE: Using the French National Registry of Childhood Solid Tumors database, all children, from birth to 28 days of age inclusive, with a primary malignant solid tumor diagnosed between 2000 and 2009 in mainland France were identified. Tumors were classified according to the third version of the International Classification of Childhood Cancer...
August 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27035612/expression-of-oct4-and-sall4-in-diffuse-large-b-cell-lymphoma-an-analysis-of-145-consecutive-cases-and-testicular-lymphomas
#14
Andrew S Williams, Allam Shawwa, Jennifer Merrimen, Kelly Dakin Haché
OCT4 and SALL4 are transcription factors within a complex network that functions to maintain pluripotency in primitive stem cells and germ cells. Nuclear expression of OCT4 is widely cited as sensitive and specific for primary and metastatic germ cell tumors and is commonly used in the diagnosis of central nervous system (CNS) germinomas. Studies have failed to systematically examine the expression of OCT4 or SALL4 in diffuse large B-cell lymphoma (DLBCL), although this entity enters the morphologic differential diagnosis of some germ cell tumors...
July 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26990854/primary-glial-and-neuronal-tumors-of-the-ovary-or-peritoneum-a-clinicopathologic-study-of-11-cases
#15
Li Liang, Adriana Olar, Na Niu, Yi Jiang, Wenjun Cheng, Xiu-Wu Bian, Wentao Yang, Jing Zhang, Anna Yemelyanova, Anais Malpica, Zhihong Zhang, Gregory N Fuller, Jinsong Liu
Primary glial and neuronal tumors of the ovary or peritoneum are rare neuroectodermal-type tumors similar to their counterparts in the central nervous system. We retrospectively reviewed 11 cases. These cases included 4 ependymomas, 6 astrocytic tumors, and 1 neurocytoma. Patients' age ranged from 9 to 50 years (mean, 26 y; median, 24 y). All ependymal tumors with detailed clinical history (n=3) were not associated with any other ovarian neoplasm. In contrast, all astrocytic tumors were associated with immature teratoma (n=4), mature cystic teratoma (n=1), or mixed germ cell tumor (n=1)...
June 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26956871/recurrent-neomorphic-mutations-of-mtor-in-central-nervous-system-and-testicular-germ-cell-tumors-may-be-targeted-for-therapy
#16
Koichi Ichimura, Shintaro Fukushima, Yasushi Totoki, Yuko Matsushita, Ayaka Otsuka, Arata Tomiyama, Tohru Niwa, Hirokazu Takami, Taishi Nakamura, Tomonari Suzuki, Kohei Fukuoka, Takaaki Yanagisawa, Kazuhiko Mishima, Yoichi Nakazato, Fumie Hosoda, Yoshitaka Narita, Soichiro Shibui, Akihiko Yoshida, Akitake Mukasa, Nobuhito Saito, Toshihiro Kumabe, Masayuki Kanamori, Teiji Tominaga, Keiichi Kobayashi, Saki Shimizu, Motoo Nagane, Toshihiko Iuchi, Masahiro Mizoguchi, Koji Yoshimoto, Kaoru Tamura, Taketoshi Maehara, Kazuhiko Sugiyama, Mitsutoshi Nakada, Keiichi Sakai, Yonehiro Kanemura, Masahiro Nonaka, Akio Asai, Kiyotaka Yokogami, Hideo Takeshima, Nobutaka Kawahara, Tatsuya Takayama, Masahiro Yao, Mamoru Kato, Hiromi Nakamura, Natsuko Hama, Ryuichi Sakai, Toshikazu Ushijima, Masao Matsutani, Tatsuhiro Shibata, Ryo Nishikawa
Germ cell tumors constitute a heterogeneous group that displays a broad spectrum of morphology. They often arise in testes; however, extragonadal occurrence, in particular brain, is not uncommon, and whether they share a common pathogenesis is unknown. We performed whole exome sequencing in 41 pairs of central nervous system germ cell tumors (CNS GCTs) of various histology and their matched normal tissues. We then performed targeted sequencing of 41 selected genes in a total of 124 CNS GCTs, 65 testicular germ cell tumors (tGCTs) and 8 metastatic GCTs to the CNS...
June 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/26726947/phase-i-study-of-temozolomide-in-combination-with-thiotepa-and-carboplatin-with-autologous-hematopoietic-cell-rescue-in-patients-with-malignant-brain-tumors-with-minimal-residual-disease
#17
G Egan, K A Cervone, P C Philips, J B Belasco, J L Finlay, S L Gardner
Recurrence of malignant brain tumors results in a poor prognosis with limited treatment options. High-dose chemotherapy with autologous hematopoietic cell rescue (AHCR) has been used in patients with recurrent malignant brain tumors and has shown improved outcomes compared with standard chemotherapy. Temozolomide is standard therapy for glioblastoma and has also shown activity in patients with medulloblastoma/primitive neuro-ectodermal tumor (PNET), particularly those with recurrent disease. Temozolomide was administered twice daily on days -10 to -6, followed by thiotepa 300 mg/m(2) per day and carboplatin dosed using the Calvert formula or body surface area on days -5 to -3, with AHCR day 0...
April 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/26517249/updates-in-molecular-pathology-of-central-nervous-system-gliomas-in-adults
#18
Michael Punsoni, John E Donahue, Heinrich D Elinzano, Timothy Kinsella
Central nervous system (CNS) tumors are a heterogeneous group of neoplasms divided into two broad categories, glial and non-glial. Non-glial tumors are derived from such diverse structures as the pineal gland, meninges, germ cells, and hematopoietic cells, as well as metastases. Primary glial neoplasms, or those which originate from astrocytes, oligodendrocytes, or ependymal cells, include astrocytomas, oligodendrogliomas, ependymomas, and mixed gliomas. Each entity has a unique morphology and pattern of biologic behavior which portends a distinct prognosis and outcome...
November 2, 2015: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/26376790/neurocytoma-arising-from-a-mature-ovary-teratoma-a-case-report
#19
Juan-Han Yu, Lian-He Yang, Xu-Yong Lin, Shun-Dong Dai, Xue-Shan Qiu, En-Hua Wang
Central neurocytoma/extraventricular neurocytoma is a central nervous system (CNS) tumor composed of uniform round cells with neuronal differentiation. The typical lesions of central neurocytoma/extraventricular neurocytoma are at the interventricular foramen of the lateral ventricles (central neurocytoma) or brain parenchyma (extraventricular neurocytoma). Mature teratoma is a benign germ cell tumor commonly found in young women. Herein, we report a 24-year-old female with neurocytoma in a mature teratoma of the right ovary...
2015: Diagnostic Pathology
https://www.readbyqxmd.com/read/26304823/incidence-trends-and-survival-of-children-with-embryonal-tumors
#20
M Tulla, F Berthold, N Graf, S Rutkowski, D von Schweinitz, C Spix, P Kaatsch
BACKGROUND: Central nervous system (CNS) and non-CNS embryonal tumors occur principally in children and are rarely seen in adults. The incidence rates for rare entities such as atypical teratoid/rhabdoid tumors (AT/RT) or primitive neuroectodermal tumors in the CNS are rarely published. Incidence rates for certain subgroups, such as hepatoblastomas, have been increasing in some countries. METHODS: Data of 8337 embryonal tumors, registered in children (0-14 years) between 1991 and 2012 (for AT/RT 2000-2012) in the population-based German Childhood Cancer Registry with complete national coverage were analyzed for incidence rates, time trends, and survival...
September 2015: Pediatrics
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