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review article: sugammadex

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https://www.readbyqxmd.com/read/27871504/efficacy-and-safety-of-sugammadex-compared-to-neostigmine-for-reversal-of-neuromuscular-blockade-a-meta-analysis-of-randomized-controlled-trials
#1
REVIEW
Michele Carron, Francesco Zarantonello, Paola Tellaroli, Carlo Ori
BACKGROUND AND OBJECTIVE: Sugammadex has been introduced for reversal of rocuronium (or vecuronium)-induced neuromuscular blockade (NMB). Although its efficacy has been established, data are conflicting whether it is safer than neostigmine traditionally used for reversing NMB. DESIGN: Meta-analysis of data about effectiveness and safety of sugammadex compared to neostigmine for reversing NMB in adults was performed using the PRISMA methodology. SETTING: University medical hospital...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/26846546/is-deep-neuromuscular-block-beneficial-in-laparoscopic-surgery-no-probably-not
#2
REVIEW
Aaron F Kopman, Mohamed Naguib
BACKGROUND: There is currently a controversy regarding the need for and clinical benefit of maintaining deep neuromuscular block (post-tetanic counts of 1 or 2) vs. moderate block (train-of-four counts of 1-3) for routine laparoscopic surgery. Two recent review articles on this subject arrived at rather different conclusions. This manuscript is part of Pro/Con debate from the authors of these two reviews. METHODS: The authors of the Pro and Con sides of the debate had the opportunity to read each other manuscripts and worked from the same basic database of references...
July 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/25625254/laparoscopic-surgery-and-muscle-relaxants-is-deep-block-helpful
#3
REVIEW
Aaron F Kopman, Mohamed Naguib
It has been hypothesized that providing deep neuromuscular block (a posttetanic count of 1 or more, but a train-of-four [TOF] count of zero) when compared with moderate block (TOF counts of 1-3) for laparoscopic surgery would allow for the use of lower inflation pressures while optimizing surgical space and enhancing patient safety. We conducted a literature search on 6 different medical databases using 3 search strategies in each database in an attempt to find data substantiating this proposition. In addition, we studied the reference lists of the articles retrieved in the search and of other relevant articles known to the authors...
January 2015: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/25579285/sugammadex-what-do-we-know-and-what-do-we-still-need-to-know-a-review-of-the-recent-2013-to-2014-literature
#4
REVIEW
T Ledowski
Since its launch in 2008, sugammadex has been considered one of the most significant developments in anaesthesia-related pharmacology. With almost 500 sugammadex-related publications and over nine million patient exposures worldwide, user experience and scientific data have grown exponentially. However, several important questions are yet to be answered. This article reviews the sugammadex-related literature in 2013 and 2014 to determine which of these questions have been answered more fully over the last 18 months and which questions require more information and research...
January 2015: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/25299638/sugammadex-a-comprehensive-review-of-the-published-human-science-including-renal-studies
#5
REVIEW
Parisa Partownavid, Bryan T Romito, Willy Ching, Ashley A Berry, Charles T Barkulis, KimNgan P Nguyen, Jonathan S Jahr
Although neuromuscular block (NMB) allows immobility for airway management and surgical exposure, termination of its effect is limited by and associated with side effects of acetylcholinesterase inhibitors. Sugammadex is a selective relaxant binding agent that has been shown to reverse deep NMB, even when administered 3 minutes following a 1.2 mg/kg dose of rocuronium. This novel drug is a modified gamma cyclodextrin, that through encapsulation process terminates the effects of rocuronium and vecuronium (aminosteroid muscle relaxants), and enables the anesthesiologists rapidly to reverse profound NMB induced by rocuronium or vecuronium, in a "can't ventilate, can't intubate" crisis...
July 2015: American Journal of Therapeutics
https://www.readbyqxmd.com/read/22454044/myths-and-facts-in-neuromuscular-pharmacology-new-developments-in-reversing-neuromuscular-blockade
#6
REVIEW
H Fink, M W Hollmann
Pharmacologic reversal of neuromuscular blockade is a topic not very well acknowledged and controversially discussed. Reasons for this are numerous and include missing perception of the potential complications of residual neuromuscular paralysis including an increased morbidity and mortality, as well as low efficacy and numerous unwanted side effects of the available antagonists. Duration of action of muscle relaxants cannot be pharmacologically predicted. Objective neuromuscular monitoring is the only way to detect residual paralysis...
April 2012: Minerva Anestesiologica
https://www.readbyqxmd.com/read/21074746/sugammadex-cyclodextrins-development-of-selective-binding-agents-pharmacology-clinical-development-and-future-directions
#7
REVIEW
Arezou Sadighi Akha, Joseph Rosa, Jonathan S Jahr, Alvin Li, Kianusch Kiai
Neuromuscular blocking agents are widely used in perioperative medicine to aid in endotracheal intubation, facilitate surgery, and in critical care/emergency medicine settings. Muscle relaxants have profound clinical uses in current surgical and intensive care and emergency medical therapy. This article reviews cyclodextrins, development of selective binding agents, clinical development, and future directions of sugammadex.
December 2010: Anesthesiology Clinics
https://www.readbyqxmd.com/read/20357160/cochrane-corner-sugammadex-a-selective-reversal-medication-for-preventing-postoperative-residual-neuromuscular-blockade
#8
Amir Abrishami, Joyce Ho, Jean Wong, Ling Yin, Frances Chung
BACKGROUND: Sugammadex is the first selective relaxant binding agent that has been studied for reversal of neuromuscular blockade induced by rocuronium and other steroidal non-depolarizing neuromuscular blocking agents (NMBAs). OBJECTIVES: To assess the efficacy and safety of sugammadex in reversing neuromuscular blockade induced by steroidal non-depolarizing NMBAs and in preventing postoperative residual neuromuscular blockade. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, Issue 3), MEDLINE (1950 to August 2008), and EMBASE (1980 to August 2008)...
April 1, 2010: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/19942337/anaesthesia-in-prehospital-emergencies-and-in-the-emergency-room
#9
REVIEW
Peter Paal, Holger Herff, Thomas Mitterlechner, Achim von Goedecke, Hermann Brugger, Karl H Lindner, Volker Wenzel
AIMS: To review anaesthesia in prehospital emergencies and in the emergency room, and to discuss guidelines for anaesthesia indication; pre-oxygenation; anaesthesia induction and drugs; airway management; anaesthesia maintenance and monitoring; side effects and training. METHODS: A literature search in the PubMed database was performed and 87 articles were included in this non-systematic review. CONCLUSIONS: For pre-oxygenation, high-flow oxygen should be delivered with a tight-fitting face-mask provided with a reservoir...
February 2010: Resuscitation
https://www.readbyqxmd.com/read/19920928/selective-reversal-of-muscle-relaxation-in-general-anesthesia-focus-on-sugammadex
#10
Sorin J Brull, Mohamed Naguib
Despite the significant improvements in the pharmacology of muscle relaxants in the past six decades, the search for the ideal muscle relaxant continues, mainly because of the incomplete efficacy and persistent side effects associated with their antagonism. Clinical concerns remain about the residual paralysis and hemodynamic side effects associated with the classic pharmacologic reversal agents, the acetylcholinesterase inhibitors. Although the development of the "ideal muscle relaxant" remains illusory, pharmacologic advancements hold promise for improved clinical care and patient safety...
2009: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/19821409/sugammadex-a-selective-reversal-medication-for-preventing-postoperative-residual-neuromuscular-blockade
#11
REVIEW
Amir Abrishami, Joyce Ho, Jean Wong, Ling Yin, Frances Chung
BACKGROUND: Sugammadex is the first selective relaxant binding agent that has been studied for reversal of neuromuscular blockade induced by rocuronium and other steroidal non-depolarizing neuromuscular blocking agents (NMBAs). OBJECTIVES: To assess the efficacy and safety of sugammadex in reversing neuromuscular blockade induced by steroidal non-depolarizing NMBAs and in preventing postoperative residual neuromuscular blockade. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, Issue 3), MEDLINE (1950 to August 2008), and EMBASE (1980 to August 2008)...
2009: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/18473711/sugammadex-a-cyclodextrin-to-reverse-neuromuscular-blockade-in-anaesthesia
#12
REVIEW
Fran├žois Donati
BACKGROUND: Neuromuscular blocking agents are used to provide relaxation and immobility during surgery. To avoid residual paralysis after anaesthesia, reversal of blockade is commonly accomplished with anticholinesterase agents but these drugs have cardiovascular side effects and incomplete effectiveness. Sugammadex is a cyclodextrin that binds rocuronium and chemically similar neuromuscular blocking drugs. OBJECTIVE: Published data on the effectiveness of sugammadex as a reversal agent were examined...
June 2008: Expert Opinion on Pharmacotherapy
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