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high resolution MRI

Xiaoqing Wang, Arun A Joseph, Oleksandr Kalentev, K Dietmar Merboldt, Dirk Voit, Volkert B Roeloffs, Maaike van Zalk, Jens Frahm
OBJECTIVE: To develop a novel method for rapid myocardial T1 mapping at high spatial resolution. METHODS: The proposed strategy represents a single-shot inversion-recovery (IR) experiment triggered to early diastole during a brief breathhold. The measurement combines an adiabatic inversion pulse with a real-time readout by highly undersampled radial FLASH, iterative image reconstruction and T1 fitting with automatic deletion of systolic frames. The method was implemented on a 3 T MRI system using a GPU-equipped bypass computer for online application...
October 19, 2016: British Journal of Radiology
Faysal F Altahawi, Kevin J Blount, Nicholas P Morley, Esther Raithel, Imran M Omar
PURPOSE: To compare a faster, new, high-resolution accelerated 3D-fast-spin-echo (3D-FSE) acquisition sequence (CS-SPACE) to traditional 2D and high-resolution 3D sequences for knee 3-T magnetic resonance imaging (MRI). MATERIALS AND METHODS: Twenty patients received knee MRIs that included routine 2D (T1, PD ± FS, T2-FS; 0.5 × 0.5 × 3 mm(3); ∼10 min), traditional 3D FSE (SPACE-PD-FS; 0.5 × 0.5 × 0.5 mm(3); ∼7.5 min), and accelerated 3D-FSE prototype (CS-SPACE-PD-FS; 0...
October 15, 2016: Skeletal Radiology
Benjamin D Levine, Kambiz Motamedi, Leanne L Seeger
The clinical diagnosis of synovial tumors and synovial proliferative processes is difficult, as symptoms and physical examination findings are often nonspecific. Advanced imaging modalities, such as MRI, high-resolution ultrasound, and computed tomography, can aid clinical decision-making by providing accurate diagnosis of such diseases in many cases. This article focuses on those specific imaging features of synovial tumors and proliferative processes that can provide accurate diagnosis and guide appropriate patient management...
November 2016: Rheumatic Diseases Clinics of North America
Gabriella Szatmáry
PURPOSE OF REVIEW: This article presents an imaging-based approach to the differential diagnosis of visual symptoms. RECENT FINDINGS: Many neurologic disorders may present with visual symptoms. Therefore, neurologists must be familiar with the array of pathophysiologic processes that cause visual symptoms. Orbital imaging is challenging owing to the small structures and different tissue interfaces within and surrounding the orbital compartment. Some of the emerging three-dimensional MRI sequences are promising and compare well with high-resolution two-dimensional sequences in the orbits...
October 2016: Continuum: Lifelong Learning in Neurology
Tao Xie, Wei Sun, Xiaobiao Zhang, Tengfei Liu, Hailing Ding, Fan Hu, Yong Yu, Ye Gu
BACKGROUND: In this study, we investigated the value of three-dimensional (3D) fast-imaging employing steady-state acquisition (FIESTA) magnetic resonance imaging (MRI) in detecting non-iatrogenic cerebrospinal fluid (CSF) rhinorrhoea and compared it with regular MRI and 3D magnetisation prepared rapid acquisition gradient echo (MPRAGE) MRI sequences, as well as high-resolution computed tomography (HRCT) imaging. We also present the endoscopic experiences of such cases. METHOD: From June 2011 to Feb 2016, 17 patients with non-iatrogenic cerebrospinal fluid rhinorrhoea were included...
October 13, 2016: Acta Neurochirurgica
Fabienne Harrisberger, Roman Buechler, Renata Smieskova, Claudia Lenz, Anna Walter, Laura Egloff, Kerstin Bendfeldt, Andor E Simon, Diana Wotruba, Anastasia Theodoridou, Wulf Rössler, Anita Riecher-Rössler, Undine E Lang, Karsten Heekeren, Stefan Borgwardt
Reduction in hippocampal volume is a hallmark of schizophrenia and already present in the clinical high-risk state. Nevertheless, other subcortical structures, such as the thalamus, amygdala and pallidum can differentiate schizophrenia patients from controls. We studied the role of hippocampal and subcortical structures in clinical high-risk individuals from two cohorts. High-resolution T1-weighted structural MRI brain scans of a total of 91 clinical high-risk individuals and 64 healthy controls were collected in two centers...
2016: NPJ Schizophrenia
Michele R Colonna, Giuseppe Tallarida, Francesco Stagno d'Alcontres, Salvatore Noto, Aurora Parodi, Alberto Tagliafico
Five years after both right ulnar and median nerve decompression for paraesthesias and palsy, a patient, coming from Nigeria but living in Italy, came to our unit claiming to have persistent pain and combined median and ulnar palsy. Under suspicion of leprosy, skin and left sural nerve biopsy were performed. Skin tests were negative, but Schwann cells resulted as positive for acid-fast bacilli (AFB), leading to the diagnosis of Pure Neuritic Leprosy (PNL). The patient was given PB multidrug therapy and recovered from pain in two months...
2016: Case Reports in Neurological Medicine
Christine Gonzales, Hikari A I Yoshihara, Nahzli Dilek, Julie Leignadier, Melita Irving, Pascal Mieville, Lothar Helm, Olivier Michielin, Juerg Schwitter
BACKGROUND: 19F-MRI and 19F-MRS can identify specific cell types after in-vitro or in-vivo 19F-labeling. Knowledge on the potential to track in-vitro 19F-labeled immune cells in tumor models by 19F-MRI/MRS is scarce. AIM: To study 19F-based MR techniques for in-vivo tracking of adoptively transferred immune cells after in-vitro 19F-labeling, i.e. to detect and monitor their migration non-invasively in melanoma-bearing mice. METHODS: Splenocytes (SP) were labeled in-vitro with a perfluorocarbon (PFC) and IV-injected into non-tumor bearing mice...
2016: PloS One
F Barchetti, A Stagnitti, V Megna, N Al Ansari, A Marini, D Musio, M L Monti, G Barchetti, V Tombolini, C Catalano, V Panebianco
OBJECTIVE: The aim of this study was to evaluate the accuracy of unenhanced whole-body MRI, including whole-body Diffusion Weighted Imaging (DWI), used as a diagnostic modality to detect  pathologic lymph nodes and skeletal metastases in patients with prostate cancer (PCa) undergoing restaging after primary treatment. PATIENTS AND METHODS: 152 male patients with biochemical recurrence after radical prostatectomy (RP) or external beam radiation therapy (EBRT) underwent MRI at a 1...
September 2016: European Review for Medical and Pharmacological Sciences
Hooman Hamedani, Stephen Kadlecek, Yi Xin, Sarmad Siddiqui, Heather Gatens, Joseph Naji, Masaru Ishii, Maurizio Cereda, Milton Rossman, Rahim Rizi
PURPOSE: To present a method for simultaneous acquisition of alveolar oxygen tension (PA O2 ), specific ventilation (SV), and apparent diffusion coefficient (ADC) of hyperpolarized (HP) gas in the human lung, allowing reinterpretation of the PA O2 and SV maps to produce a map of oxygen uptake (R). METHOD: An imaging scheme was designed with a series of identical normoxic HP gas wash-in breaths to measure ADC, SV, PA O2 , and R in less than 2 min. Signal dynamics were fit to an iterative recursive model that regionally solved for these parameters...
October 13, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Emilio Luis González-Martínez, David Santamarta
BACKGROUND: Late-onset idiopathic aqueductal stenosis may present with clinical features indistinct from idiopathic normal-pressure hydrocephalus (NPH). Moreover, aqueductal stenosis (AS) is not always detected by conventional magnetic resonance imaging (MRI). The aim of this study was to compare the hydrodynamic pattern among NPH patients according to the patency of the aqueduct. METHODS: Fifty-six consecutive lumbar infusion tests were performed in patients with NPH syndrome...
October 11, 2016: Acta Neurochirurgica
Musaed Alzahrani, Rami Alhazmi, Manon Bélair, Issam Saliba
OBJECTIVE: To evaluate the ability of preoperative mastoid high resolution Computerized tomography (CT Scan) fusion with the postoperative diffusion weighted magnetic resonance imaging (Non-EPI DWI) to accurately localize the residual cholesteatoma thus sparing an unnecessary postoperative CT scan radiation. PATIENTS AND METHODS: this is a prospective study performed in our tertiary care center. We followed up prospectively a consecutive group of patients presenting with middle ear cholesteatoma using preoperative mastoid CT scans, postoperative mastoid CT scan and mastoid diffusion weighted MRI (DWI) between 2012 and 2013...
November 2016: International Journal of Pediatric Otorhinolaryngology
Mingming Wang, Fengguo Zhang, Lei Xu, Yun Xiao, Jianfeng Li, Zhaomin Fan, Qian Sun, Xiaohui Bai, Haibo Wang
OBJECTIVE: To identify the disease-related SLC26A4 mutants in a Chinese Han pedigree associated with Enlarged vestibular aqueduct (EVA). METHODS: EVA diagnosis was based on the family history, clinical examinations, systematically audiometric evaluations, high-resolution computed tomography (HRCT) of the temporal bone, and magnetic resonance imaging (MRI) of inner ear. Sanger sequencing and mutation analysis of the SLC26A4 gene were performed in all members of this family to identify the disease-related SLC26A4 mutants...
November 2016: International Journal of Pediatric Otorhinolaryngology
Bonnie Alexander, Andrea L Murray, Wai Yen Loh, Lillian G Matthews, Chris Adamson, Richard Beare, Jian Chen, Claire E Kelly, Sandra Rees, Simon K Warfield, Peter J Anderson, Lex W Doyle, Alicia J Spittle, Jeanie L Y Cheong, Marc L Seal, Deanne K Thompson
Investigating neonatal brain structure and function can offer valuable insights into behaviour and cognition in healthy and clinical populations; both at term age, and longitudinally in comparison with later time points. Parcellated brain atlases for adult populations are readily available, however warping infant data to adult template space is not ideal due to morphological and tissue differences between these groups. Several parcellated neonatal atlases have been developed, although there remains strong demand for manually parcellated ground truth data with detailed cortical definition...
October 7, 2016: NeuroImage
Iris Asllani, Pamelia Slattery, Alexander Fafard, Marykay Pavol, Ronald M Lazar, Randolph S Marshall
Despite being considered an important anatomical parameter directly related to neuronal density, cortical thickness is not routinely assessed in studies of the human brain in vivo. This paucity has been largely due to the size and convoluted shape of the human cortex, which has made it difficult to develop automated algorithms that can measure cortical thickness efficiently and reliably. Since the development of such an algorithm by Fischl and Dale in 2000, the number of studies investigating the relationship between cortical thickness and other physiological parameters in the brain has been on the rise...
2016: NeuroImage: Clinical
Jackie Leung, James Duffin, Joseph A Fisher, Andrea Kassner
OBJECTIVES: Cerebrovascular reactivity (CVR) measures the ability of cerebral blood vessels to change their diameter and, hence, their capacity to regulate regional blood flow in the brain. High resolution quantitative maps of CVR can be produced using blood-oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) in combination with a carbon dioxide stimulus, and these maps have become a useful tool in the clinical evaluation of cerebrovascular disorders. However, conventional CVR analysis does not fully characterize the BOLD response to a stimulus as certain regions of the brain are slower to react to the stimulus than others, especially in disease...
2016: NeuroImage: Clinical
David O Prichard, Taehee Lee, Gopanandan Parthasarathy, Joel G Fletcher, Alan R Zinsmeister, Adil E Bharucha
BACKGROUND & AIMS: Contrary to conventional wisdom, the rectoanal gradient during evacuation is negative in many healthy people, undermining the utility of anorectal high resolution manometry (HRM) for diagnosing defecatory disorders. We aimed to compare HRM and magnetic resonance imaging (MRI) for assessing rectal evacuation and structural abnormalities. METHODS: We performed a retrospective analysis of 118 patients (all female; 51 with constipation, 48 with fecal incontinence, and 19 with rectal prolapse; age, 53±1 years) assessed by HRM, the rectal balloon expulsion test (BET), and MRI at Mayo Clinic, Rochester, Minnesota, from February 2011 through March 2013...
October 5, 2016: Clinical Gastroenterology and Hepatology
Robert J Harris, Timothy F Cloughesy, Linda M Liau, Phioanh L Nghiemphu, Albert Lai, Whitney B Pope, Benjamin M Ellingson
Acidity within the extracellular milieu is a hallmark of cancer. There is a current need for fast, high spatial resolution pH imaging techniques for clinical evaluation of cancers, including gliomas. Chemical exchange saturation transfer (CEST) MRI targeting fast-exchanging amine protons can be used to obtain high-resolution pH-weighted images, but conventional CEST acquisition strategies are slow. There is also a need for more accurate MR simulations to better understand the effects of amine CEST pulse sequence parameters on pH-weighted image contrast...
September 15, 2016: NMR in Biomedicine
Bart W J Philips, Ansje S Fortuin, Stephan Orzada, Tom W J Scheenen, Marnix C Maas
PURPOSE: Pelvic lymph node (PLN) metastases are often smaller than 5 mm and difficult to detect. This work presents a method to perform PLN imaging with ultrahigh-field MRI, using spectrally selective excitation to acquire water and lipid-selective imaging at high spatial resolution. METHODS: A 3D water-selective multigradient echo (mGRE) sequence and lipid-selective gradient echo (GRE) sequence were tested in six healthy volunteers on a 7 Tesla (T) MRI system, using time interleaved acquisition of modes (TIAMO) to improve image homogeneity...
October 7, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Nikos Makris, A Zhu, G M Papadimitriou, P Mouradian, I Ng, E Scaccianoce, G Baselli, F Baglio, M E Shenton, Y Rathi, B Dickerson, E Yeterian, M Kubicki
Originally, the middle longitudinal fascicle (MdLF) was defined as a long association fiber tract connecting the superior temporal gyrus and temporal pole with the angular gyrus. More recently its description has been expanded to include all long postrolandic cortico-cortical association connections of the superior temporal gyrus and dorsal temporal pole with the parietal and occipital lobes. Despite its location and size, which makes MdLF one of the most prominent cerebral association fiber tracts, its discovery in humans is recent...
October 6, 2016: Brain Imaging and Behavior
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