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https://www.readbyqxmd.com/read/28929896/une-analyse-%C3%A3-thique-appropri%C3%A3-e-s-impose
#1
Don Flaming
Les leaders en santé gèrent de nombreux types de risques. Le risque éthique associé aux multiples projets et activités, réalisés régulièrement hors du secteur de la recherche, est probablement négligé (p. ex., évaluation de programmes, amélioration de la qualité et innovation en santé). La mise en application de l'éthique clinique, personnelle, professionnelle et organisationnelle peut contribuer à atténuer les risques, mais ensemble ou séparément, ces divers types d'éthique ne suffisent pas...
January 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929891/la-haute-fiabilit%C3%A3-en-soins-de-sant%C3%A3-la-cr%C3%A3-ation-d-une-culture-et-d-une-mentalit%C3%A3-favorisant-la-s%C3%A3-curit%C3%A3-des-patients
#2
Bonnie S Cochrane, Mitch Hagins, Gino Picciano, John A King, David A Marshall, Brian Nelson, Craig Deao
Les préjudices que subissent les patients recevant des soins de santé représentent un fardeau considérable et peuvent avoir de graves répercussions sur les patients et les familles ainsi que sur la capacité des systèmes de santé de gérer l'accès des patients, leurs déplacements dans le système et les temps d'attente. L'intérêt pour la science de la haute fiabilité, mise au point à l'origine dans des secteurs comme l'aviation commerciale, qui ont un bilan exceptionnel en matière de sécurité, est une nouvelle tendance en soins de santé qui pourrait aider les organisations et les systèmes à atteindre le but ultime : zéro préjudice subi par les patients...
March 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28928192/a-pragmatic-group-sequential-placebo-controlled-randomised-trial-to-determine-the-effectiveness-of-glyceryl-trinitrate-for-retained-placenta-got-it-a-study-protocol
#3
Fiona C Denison, John Norrie, Julia Lawton, Jane E Norman, Graham Scotland, Gladys C McPherson, Alison McDonald, Mark Forrest, Jemma Hudson, Jane Brewin, Mathilde Peace, Cynthia Clarkson, Sheonagh Brook-Smith, Susan Morrow, Nina Hallowell, Laura Hodges, Kathryn F Carruthers
INTRODUCTION: A retained placenta is diagnosed when the placenta is not delivered following delivery of the baby. It is a major cause of postpartum haemorrhage and treated by the operative procedure of manual removal of placenta (MROP). METHODS AND ANALYSIS: The aim of this pragmatic, randomised, placebo-controlled, double-blind UK-wide trial, with an internal pilot and nested qualitative research to adjust strategies to refine delivery of the main trial, is to determine whether sublingual glyceryl trinitrate (GTN) is (or is not) clinically and cost-effective for (medical) management of retained placenta...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28928096/burnout-is-associated-with-changes-in-error-and-feedback-processing
#4
Patrick D Gajewski, Sylvia Boden, Gabriele Freude, Guy G Potter, Michael Falkenstein
Burnout is a pattern of complaints in individuals with emotionally demanding jobs that is often seen as a precursor of depression. One often reported symptom of burnout is cognitive decline. To analyze cognitive control and to differentiate between subclinical burnout and mild-to-moderate depression a double-blinded study was conducted that investigates changes in the processing of performance errors and feedback in a task switching paradigm. Fifty-one of 76 employees from emotionally demanding jobs showed a sufficient number of errors to be included in the analysis...
September 16, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28926812/isotope-and-microbiome-data-provide-complementary-information-to-identify-natural-nitrate-attenuation-processes-in-groundwater
#5
Elena Hernández-Del Amo, Anna Menció, Frederic Gich, Josep Mas-Pla, Lluís Bañeras
Natural attenuation processes alleviate the impact of fertilization practices on groundwater resources. Therefore, identifying the occurrence of denitrification has become a requirement for water quality management. Several approaches are useful for this purpose, such as isotopic and microbiological methods, each of them providing distinct but complementary information about denitrification reactions, attenuation rates and their occurrence in the aquifer. In this paper, we investigate the contribution of both approaches to describe denitrification in a consolidated rock aquifer (limestone and marls), with a porosity related to fracture networks located in the northeastern sector of the Osona basin (NE Spain)...
September 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28924555/early-changes-in-brain-structure-correlate-with-language-outcomes-in-children-with-neonatal-encephalopathy
#6
Kevin A Shapiro, Hosung Kim, Maria Luisa Mandelli, Elizabeth E Rogers, Dawn Gano, Donna M Ferriero, A James Barkovich, Maria Luisa Gorno-Tempini, Hannah C Glass, Duan Xu
Global patterns of brain injury correlate with motor, cognitive, and language outcomes in survivors of neonatal encephalopathy (NE). However, it is still unclear whether local changes in brain structure predict specific deficits. We therefore examined whether differences in brain structure at 6 months of age are associated with neurodevelopmental outcomes in this population. We enrolled 32 children with NE, performed structural brain MR imaging at 6 months, and assessed neurodevelopmental outcomes at 30 months...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28923436/changes-in-hepatic-gene-expression-and-serum-metabolites-after-oral-administration-of-overdosed-vitamin-e-loaded-nanoemulsion-in-rats
#7
Chae Young Park, Chul Ho Jang, Do Yup Lee, Hyung Taek Cho, Young Jun Kim, Yoo Heon Park, Jee-Young Imm
Vitamin-E-loaded nanoemulsion (Vit E-NE) was produced, and the effects of repeated oral administration of Vit E-NE (2 g/kg/day) for five days on hepatic gene expression and serum metabolites were investigated in rats. The mean particle diameter and zeta potential of Vit E-NE was 112 nm and 56 mV, respectively. Vit E-NE administered rats showed significantly higher triglyceride content than of standard diet (control) or Vit E control emulsion (Vit E-CE) group but no toxicity symptoms were found in blood biochemical analysis...
September 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28918943/vagus-nerve-stimulation-improves-locomotion-and-neuronal-populations-in-a-model-of-parkinson-s-disease
#8
Ariana Q Farrand, Kristi L Helke, Rebecca A Gregory, Monika Gooz, Vanessa K Hinson, Heather A Boger
BACKGROUND: Parkinson's disease (PD) is a progressive, neurodegenerative disorder with no disease-modifying therapies, and symptomatic treatments are often limited by debilitating side effects. In PD, locus coeruleus noradrenergic (LC-NE) neurons degenerate prior to substantia nigra dopaminergic (SN-DA) neurons. Vagus nerve stimulation (VNS) activates LC neurons, and decreases pro-inflammatory markers, allowing improvement of LC targets, making it a potential PD therapeutic. OBJECTIVE: To assess therapeutic potential of VNS in a PD model...
August 24, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28918287/steroid-hormones-and-persistent-organic-pollutants-in-plasma-from-north-eastern-atlantic-pilot-whales
#9
Katrin S Hoydal, Bjarne Styrishave, Tomasz M Ciesielski, Robert J Letcher, Maria Dam, Bjørn M Jenssen
Persistent organic pollutants (POPs) are known to have endocrine disruptive effects, interfering with endogenous steroid hormones. The present study examined nine steroid hormones and their relationships with the concentrations of selected POPs in pilot whales (Globicephala melas) from the Faroe Islands, NE Atlantic. The different steroids were detected in 15 to all of the 26 individuals. High concentrations of progesterone (83.3-211.7pmol/g) and pregnenolone (PRE; 4.68-5.69pmol/g) were found in three adult females indicating that they were pregnant or ovulating...
September 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28918084/uranium-isotopes-in-tree-bark-as-a-spatial-tracer-of-environmental-contamination-near-former-uranium-processing-facilities-in-southwest-ohio
#10
Elise Conte, Elisabeth Widom, David Kuentz
Inappropriate handling of radioactive waste at nuclear facilities can introduce non-natural uranium (U) into the environment via the air or groundwater, leading to anthropogenic increases in U concentrations. Uranium isotopic analyses of natural materials (e.g. soil, plants or water) provide a means to distinguish between natural and anthropogenic U in areas near sources of radionuclides to the environment. This study examines the utility of two different tree bark transects for resolving the areal extent of U atmospheric contamination using several locations in southwest Ohio that historically processed U...
September 14, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28914534/stochastic-formulation-of-the-resolution-of-identity-application-to-second-order-m%C3%A3-ller-plesset-perturbation-theory
#11
Tyler Y Takeshita, Wibe A de Jong, Daniel Neuhauser, Roi Baer, Eran Rabani
A stochastic orbital approach to the resolution of identity (RI) approximation for 4-index electron repulsion integrals (ERIs) is presented. The stochastic RI-ERIs are then applied to second order Møller-Plesset perturbation theory (MP2) utilizing a multiple stochastic orbital approach. The introduction of multiple stochastic orbitals results in an O(NAO(3)) scaling for both the stochastic RI-ERIs and stochastic RI-MP2, NAO being the number of basis functions. For a range of water clusters we demonstrate that this method exhibits a small prefactor and observed scalings of O(Ne(2...
September 15, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28914474/determination-of-net-energy-content-of-soybean-oil-fed-to-growing-pigs-using-indirect-calorimetry
#12
Enkai Li, Zhiqian Lv, Hu Liu, Ling Liu, Yakui Li, Zhongchao Li, Fenglai Wang, Defa Li, Shuai Zhang
The objectives of this experiment were: (i) to determine the net energy (NE) of soybean oil (SBO) fed to growing pigs using indirect calorimetry (IC); and (ii) to evaluate the effects of inclusion rate of SBO on heat production, oxidative status and nutrient digestibility in growing pigs. Eighteen growing barrows were allotted to three diets based on completely randomized design with six replicate pigs (period) per diet. Diets included a corn-soybean meal basal diet and two test diets containing 5% or 10% SBO at the expense of corn and soybean meal...
September 15, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28912793/diverse-rice-landraces-of-north-east-india-enables-the-identification-of-novel-genetic-resources-for-magnaporthe-resistance
#13
Bangale Umakanth, Balija Vishalakshi, P Sathish Kumar, S J S Rama Devi, Vijay Pal Bhadana, P Senguttuvel, Sudhir Kumar, Susheel Kumar Sharma, Pawan Kumar Sharma, M S Prasad, Maganti S Madhav
North-East (NE) India, the probable origin of rice has diverse genetic resources. Many rice landraces of NE India were not yet characterized for blast resistance. A set of 232 landraces of NE India, were screened for field resistance at two different hotspots of rice blast, viz., IIRR-UBN, Hyderabad and ICAR-NEH, Manipur in two consecutive seasons. The phenotypic evaluation as well as gene profiling for 12 major blast resistance genes (Pitp, Pi33, Pi54, Pib, Pi20, Pi38, Pita2, Pi1, Piz, Pi9, Pizt, and Pi40) with linked as well as gene-specific markers, identified 84 resistant landraces possessing different gene(s) either in singly or in combinations and also identified seven resistant landraces which do not have the tested genes, indicating the valuable genetic resources for blast resistance...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28912689/monoamine-release-in-the-cat-lumbar-spinal-cord-during-fictive-locomotion-evoked-by-the-mesencephalic-locomotor-region
#14
Brian R Noga, Riza P Turkson, Songtao Xie, Annette Taberner, Alberto Pinzon, Ian D Hentall
Spinal cord neurons active during locomotion are innervated by descending axons that release the monoamines serotonin (5-HT) and norepinephrine (NE) and these neurons express monoaminergic receptor subtypes implicated in the control of locomotion. The timing, level and spinal locations of release of these two substances during centrally-generated locomotor activity should therefore be critical to this control. These variables were measured in real time by fast-cyclic voltammetry in the decerebrate cat's lumbar spinal cord during fictive locomotion, which was evoked by electrical stimulation of the mesencephalic locomotor region (MLR) and registered as integrated activity in bilateral peripheral nerves to hindlimb muscles...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28912481/analytical-property-of-scattering-matrix-spectroscopy-phenomena-and-sharp-overlapping-autoionization-resonances
#15
Rui Jin, Xiao-Ying Han, Xiang Gao, De-Ling Zeng, Jia-Ming Li
An extended atomic data base with sufficiently high precision is required in astrophysics studies and the energy researches. For example, there are "infinite" energy levels in discrete energy region as well as overlapping resonances in autoionization region. We show in this paper the merits of our relativistic eigenchannel R-matrix method R-R-Eigen based on the analytical continuation properties of scattering matrices for the calculations of the energy levels, overlapping resonances and the related transitions...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910671/delayed-effects-of-accelerated-heavy-ions-on-the-induction-of-hprt-mutations-in-v79-hamster-cells
#16
Pavel Bláha, Nataliya A Koshlan, Igor V Koshlan, Daria V Petrova, Yulia V Bogdanova, Raisa D Govorun, Viliam Múčka, Evgeny A Krasavin
Fundamental research on the harmful effects of ionizing radiation on living cells continues to be of great interest. Recently, priority has been given to the study of high-charge and high-energy (HZE) ions that comprise a substantial part of the galactic cosmic ray (GCR) spectra that would be encountered during long-term space flights. Moreover, predictions of the delayed genetic effects of high linear energy transfer (LET) exposure is becoming more important as heavy ion therapy use is increasing. This work focuses mainly on the basic research on the delayed effects of HZE ions on V79 Chinese hamster cells, with emphasis on the induction of HPRT mutations after prolonged expression times (ET)...
August 31, 2017: Mutation Research
https://www.readbyqxmd.com/read/28910105/modeling-oil-shale-pyrolysis-high-temperature-unimolecular-decomposition-pathways-for-thiophene
#17
AnGayle K Vasiliou, Hui Hu, Thomas W Cowell, Jared C Whitman, Jessica Porterfield, Carol A Parish
The thermal decomposition mechanism of thiophene has been investigated both experimentally and theoretically. Thermal decomposition experiments were done using a 1 mm x 3 cm pulsed silicon carbide microtubular reactor, Unlike previous studies these experiments were able to identify the initial thiophene decomposition products. Thiophene was entrained in either Ar, Ne or He carrier gas, passed through a heated (300-1700 K) SiC microtubular reactor (roughly ≤100 μs residence time), and exited into a vacuum chamber...
September 14, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28900460/manual-acupuncture-at-pc6-ameliorates-acute-restraint-stress-induced-anxiety-in-rats-by-normalizing-amygdaloid-noradrenergic-response
#18
ZhengLin Zhao, Sang Chan Kim, HongFeng Liu, Jie Zhang, YuHua Wang, Il Je Cho, Bong Hyo Lee, Chang Hyun Song, Chul Won Lee, Chae Ha Yang, RongJie Zhao, YiYan Wu
Acupuncture improves ethanol withdrawal-induced anxiety in rats in an acupoint-dependent manner. Thus, the present study investigated the effects of acupuncture on acute restraint stress- (ARS-) induced anxiety. Male rats were exposed to ARS for 3 h followed by acupuncture at either PC6 (Neiguan), HT7 (Shenmen), or a nonacupoint (tail) once a day for three consecutive days. Five minutes after the third acupuncture treatment, anxiety-like behavior was evaluated in an elevated plus maze (EPM). Additionally, plasma corticosterone (CORT) levels were measured by radioimmunoassay and the concentrations of norepinephrine (NE) and 3-methoxy-4-hydroxy-phenylglycol (MHPG) in the central nucleus of the amygdala (CeA) were determined using high-performance liquid chromatography...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28900009/on-the-origin-of-shape-fluctuations-of-the-cell-nucleus
#19
Fang-Yi Chu, Shannon C Haley, Alexandra Zidovska
The nuclear envelope (NE) presents a physical boundary between the cytoplasm and the nucleoplasm, sandwiched in between two highly active systems inside the cell: cytoskeleton and chromatin. NE defines the shape and size of the cell nucleus, which increases during the cell cycle, accommodating for chromosome decondensation followed by genome duplication. In this work, we study nuclear shape fluctuations at short time scales of seconds in human cells. Using spinning disk confocal microscopy, we observe fast fluctuations of the NE, visualized by fluorescently labeled lamin A, and of the chromatin globule surface (CGS) underneath the NE, visualized by fluorescently labeled histone H2B...
September 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28899764/iron-oxide-core-oil-in-water-nanoemulsion-as-tracer-for-atherosclerosis-mpi-and-mri-imaging
#20
Geoffrey Prévot, Tina Kauss, Cyril Lorenzato, Alexandra Gaubert, Mélusine Larivière, Julie Baillet, Jeanny Laroche-Traineau, Marie Josée Jacobin-Valat, Laurent Adumeau, Stéphane Mornet, Philippe Barthélémy, Martine Duonor-Cérutti, Gisèle Clofent-Sanchez, Sylvie Crauste-Manciet
PURPOSE: For early atherosclerosis imaging, magnetic oil-in-water nanoemulsion (NE) decorated with atheroma specific monoclonal antibody was designed for Magnetic Particle Imaging (MPI) and Magnetic Resonance Imaging (MRI). MPI is an emerging technique based on direct mapping of superparamagnetic nanoparticles which may advantageously complement MRI. METHODS: NE oily droplets were loaded with superparamagnetic iron oxide nanoparticles of 7, 11 and 18nm and biofunctionalized with atheroma specific scFv-Fc TEG4-2C antibody...
September 9, 2017: International Journal of Pharmaceutics
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