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https://www.readbyqxmd.com/read/28635493/the-structure-of-lamin-filaments-in-somatic-cells-as-revealed-by-cryo-electron-tomography
#1
Y Turgay, O Medalia
Metazoan nuclei are equipped with nuclear lamina - a thin layer of intermediate filaments (IFs) mostly built of nuclear lamins facing the inner nuclear membrane (INM). The nuclear lamina serves as an interaction hub for INM-proteins, soluble nuclear factors and DNA. It confers structural and mechanical stability to the nucleus, transduces mechanical forces and biochemical signals across the nuclear envelope (NE) and regulates the organization of chromatin. By utilizing cryo-electron tomography (cryo-ET), we recently provided an unprecedented view into the 3D organization of lamin filaments within the lamina meshwork in mammalian somatic cells...
June 21, 2017: Nucleus
https://www.readbyqxmd.com/read/28635334/timing-of-food-intake-during-simulated-night-shift-impacts-glucose-metabolism-a-controlled-study
#2
Crystal L Grant, Alison M Coates, Jillian Dorrian, David J Kennaway, Gary A Wittert, Leonie K Heilbronn, Maja Pajcin, Chris Della Vedova, Charlotte C Gupta, Siobhan Banks
Eating during the night may increase the risk for obesity and type 2 diabetes in shift workers. This study examined the impact of either eating or not eating a meal at night on glucose metabolism. Participants underwent four nights of simulated night work (SW1-4, 16:00-10:00 h, <50 lux) with a daytime sleep opportunity each day (10:00-16:00 h, <3 lux). Healthy males were assigned to an eating at night (NE; n = 4, meals; 07:00, 19:00 and 01:30 h) or not eating at night (NEN; n = 7, meals; 07:00 h, 09:30, 16:10 and 19:00 h) condition...
June 21, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28633101/assessment-of-environmental-and-health-risks-in-former-polymetallic-ore-mining-and-smelting-area-slovakia-spatial-distribution-and-accumulation-of-mercury-in-four-different-ecosystems
#3
Július Árvay, Lenka Demková, Martin Hauptvogl, Miloslav Michalko, Daniel Bajčan, Radovan Stanovič, Ján Tomáš, Miroslava Hrstková, Pavol Trebichalský
Former long-term mining and smelting of pollymetallic ores in the Middle Spiš area caused a serious contamination problem of the environment with heavy metals and metalloids, especially mercury (Hg). Several studies have reported concentration of Hg in the area but this paper provides first detailed characterization of Hg contamination of different environmental components in agricultural, forest, grassland and urban ecosystems. The ecosystems are in different distances from emission sources - former mercury and copper smelting plants in NE Slovakia...
June 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28631924/insight-into-the-bonding-mechanism-and-the-bonding-covalency-in-noble-gas-noble-metal-halides-an-nbo-nrt-investigation
#4
Guiqiu Zhang, Lei Fu, Hong Li, Xuchan Fan, De-Zhan Chen
The bonding between noble gas and noble metal halide like hydrogen bonding (H-bonding) motivates us to investigate the bonding mechanism and the bonding covalency in NgMX (Ng = He, Ne, Ar, Kr, Xe, Rn; M = Cu, Ag, Au; X = F, Cl, Br, I) complexes using Natural Bond Orbital (NBO) and Natural Resonance Theory (NRT) methods. In this study, we introduce the new resonance bonding model in H-bonding into NgMX bonding. We provide strong evidence for resonance bonding involving two important resonance structures: Ng: M-X ↔ Ng(+)-M :X(-) in each of NgMX complexes, originating in the nNg→σ*MX hyperconjugative interaction...
June 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28630892/disruption-of-the-axonal-trafficking-of-tyrosine-hydroxylase-mrna-impairs-catecholamine-biosynthesis-in-the-axons-of-sympathetic-neurons
#5
Armaz Aschrafi, Anthony E Gioio, Lijin Dong, Barry B Kaplan
Tyrosine hydroxylase (TH) is the enzyme that catalyzes the rate-limiting step in the biosynthesis of the catecholamine neurotransmitters. In a previous communication, evidence was provided that TH mRNA is trafficked to the axon, where it is locally translated. In addition, a 50-bp sequence element in the 3'untranslated region (3'UTR) of TH mRNA was identified that directs TH mRNA to distal axons (i.e., zip-code). In the present study, the hypothesis was tested that local translation of TH plays an important role in the biosynthesis of the catecholamine neurotransmitters in the axon and/or presynaptic nerve terminal...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28628797/attenuated-error-related-potentials-in-amyotrophic-lateral-sclerosis-with-executive-dysfunctions
#6
Caroline Seer, Max Joop, Florian Lange, Christian Lange, Reinhard Dengler, Susanne Petri, Bruno Kopp
OBJECTIVE: Executive dysfunctions affect up to 50% of the patients with amyotrophic lateral sclerosis (ALS). Executive dysfunctions have been identified as negative prognostic factor and can affect quality of life in patients and their caregivers. Assessment of executive dysfunction may be impeded by the patients' motor impairments. Event-related potentials (ERP) have been proposed as a tool to overcome these assessment difficulties. The error(-related) negativity (Ne/ERN) is an ERP which can be recorded with minimal motor requirements for the patient...
May 18, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28628026/-dynamics-of-occurrence-and-regression-of-neutrophil-extracellular-traps-in-the-experimental-model-of-the-wound-infectious-inflammatory-process
#7
I Nesterova, A Evglevsky, G Chudilova, S Kovaleva, L Lomtatidze
The dynamics of the appearance and regression of neutrophilic extracellular traps (NETs) in the experimental model of the wound infectious-inflammatory process that was caused by infection of open wounds by microbes surrounding environment, was studied. It was established that on the second day from the start of the experiment a significant number of mature neutrophilic granulocytes show the ability to form NEТs. The number of NETs was reached its maximum by the 2th and 4th days from the beginning of the experiment, that was associated with maximum occurrence of symptoms of inflammation in the wound...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28627574/knockout-driven-fragmentation-of-porphyrins
#8
Linda Giacomozzi, Michael Gatchell, Nathalie de Ruette, Michael Wolf, Giovanna D'Angelo, Henning T Schmidt, Henrik Cederquist, Henning Zettergren
We have studied collisions between tetraphenylporphyrin cations and He or Ne at center-of-mass energies in the range 50-110 eV. The experimental results were interpreted in view of density functional theory calculations of dissociation energies and classical molecular dynamics simulations of how the molecules respond to the He/Ne impact. We demonstrate that prompt atom knockout strongly contributes to the total destruction cross sections. Such impulse driven processes typically yield highly reactive fragments and are expected to be important for collisions with any molecular system in this collision energy range, but have earlier been very difficult to isolate for biomolecules...
June 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28625779/multiple-isoforms-of-nesprin1-are-integral-components-of-ciliary-rootlets
#9
Chloe Potter, Wanqiu Zhu, David Razafsky, Philip Ruzycki, Alexander V Kolesnikov, Teresa Doggett, Vladimir J Kefalov, Ewelina Betleja, Moe R Mahjoub, Didier Hodzic
SYNE1 (synaptic nuclear envelope 1) encodes multiple isoforms of Nesprin1 (nuclear envelope spectrin 1) that associate with the nuclear envelope (NE) through a C-terminal KASH (Klarsicht/Anc1/Syne homology) domain (Figure 1A) [1-4]. This domain interacts directly with the SUN (Sad1/Unc84) domain of Sun proteins [5-7], a family of transmembrane proteins of the inner nuclear membrane (INM) [8, 9], to form the so-called LINC complexes (linkers of the nucleoskeleton and cytoskeleton) that span the entire NE and mediate nuclear positioning [10-12]...
June 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28625256/-comparison-of-effect-of-norepinephrine-and-terlipressin-on-patients-with-ards-combined-with-septic-shock-a-prospective-single-blind-randomized-controlled-trial
#10
Zhi Chen, Ping Zhou, Yuanhua Lu, Chunli Yang
OBJECTIVE: To approach the effect of different vasopressor on hemodynamics, volume responsiveness, fluid volume balance, renal function and prognosis in patients with acute respiratory distress syndrome (ARDS) complicated with septic shock. METHODS: A prospective single-blind randomized controlled trial was conducted. ARDS patients with septic shock admitted to the Department of Critical Care Medicine of Jiangxi Provincial People's Hospital from January 1st, 2015 to May 1st, 2016 were enrolled...
February 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28623827/changes-in-aquatic-microbial-responses-to-c-substrates-with-stream-water-and-sediment-quality-related-to-land-use-pressures
#11
Marc I Stutter, Jonathan Cains
The degradation of aquatic ecosystems by multiply-acting stressors is a key threat requiring new approaches to identify impairment processes and restoration targets. Heterotrophic respiration of C-substrates can be an integrative indicator of how aquatic ecosystems respond to pollution. We utilised sixteen C-substrates (simple metabolites to dissolved organic matter (DOM)) to characterise substrate induced respiration (SIR) for sediments from sixteen NE Scotland streams covering a range of land use-related pollution pressures...
June 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28621733/discovery-of-indeno-1-2-c-quinoline-derivatives-as-potent-dual-antituberculosis-and-anti-inflammatory-agents
#12
Chih-Hua Tseng, Chun-Wei Tung, Chen-Hsin Wu, Cherng-Chyi Tzeng, Yen-Hsu Chen, Tsong-Long Hwang, Yeh-Long Chen
A series of indeno[1,2-c]quinoline derivatives were designed, synthesized and evaluated for their anti-tuberculosis (anti-TB) and anti-inflammatory activities. The minimum inhibitory concentration (MIC) of the newly synthesized compound was tested against Mycobacterium tuberculosis H37RV. Among the tested compounds, (E)-N'-[6-(4-hydroxypiperidin-1-yl)-11H-indeno[1,2-c]quinolin-11-ylidene]isonicotino-hydrazide (12), exhibited significant activities against the growth of M. tuberculosis (MIC values of 0.96 μg/mL) with a potency approximately equal to that of isoniazid (INH), an anti-TB drug...
June 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28616929/-clinical-medicinethe-evaluation-of-he-ne-laser-therapy-help-wound-healing-of-nail-surgery
#13
Rong Mei, Wen-Bin Zhao, Si-Liang Xue
OBJECTIVES: To investigate the effect of He-Ne laser therapy on wound healing after nail surgery. METHODS: Patients who needed nail surgery were divided into treatment group (n=20) and control group (n=20) randomly.The He-Ne laser was applied to the wound after nail surgery in treatment group. The wound healing time, the inflammation duration, the pain rating, and the nail plate full-grown time were compared with control group. RESULTS: No significant differences in baseline of two groups were observed...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28615641/an-earlier-revolution-genetic-and-genomic-analyses-reveal-pre-existing-cultural-differences-leading-to-neolithization
#14
Michela Leonardi, Guido Barbujani, Andrea Manica
Archaeological evidence shows that, in the long run, Neolitization (the transition from foraging to food production) was associated with demographic growth. We used two methods (patterns of linkage disequilibrium from whole-genome SNPs and MSMC estimates on genomes) to reconstruct the demographic profiles for respectively 64 and 24 modern-day populations with contrasting lifestyles across the Old World (sub-Saharan Africa, south-eastern Asia, Siberia). Surprisingly, in all regions, food producers had larger effective population sizes (N e) than foragers already 20 k years ago, well before the Neolithic revolution...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28614966/persistently-elevated-nuchal-translucency-and-the-fetal-heart
#15
Trisha V Vigneswaran, Tessa Homfray, Lindsey D Allan, John M Simpson, Vita Zidere
We describe the outcome of fifteen cases with an elevated nuchal translucency (NT) which persisted into the second trimester as nuchal edema (NE) > 6 mm whom underwent fetal echocardiography. Cases were identified following retrospective review of cardiac and genetic findings with NE. Minor congenital heart disease was identified in 3/15 by the second trimester. Agenesis of the ductus venosus was evident in four. Pulmonary valve stenosis was diagnosed in one fetus at the 20-week scan and hypertrophic cardiomyopathy in one...
June 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28611772/bovine-polymorphonuclear-neutrophils-cast-neutrophil-extracellular-traps-against-the-abortive-parasite-neospora-caninum
#16
Rodolfo Villagra-Blanco, Liliana M R Silva, Tamara Muñoz-Caro, Zhengtao Yang, Jianhua Li, Ulrich Gärtner, Anja Taubert, Xichen Zhang, Carlos Hermosilla
Neospora caninum represents a relevant apicomplexan parasite causing severe reproductive disorders in cattle worldwide. Neutrophil extracellular trap (NET) generation was recently described as an efficient defense mechanism of polymorphonuclear neutrophils (PMN) acting against different parasites. In vitro interactions of bovine PMN with N. caninum were analyzed at different ratios and time spans. Extracellular DNA staining was used to illustrate the typical molecules of NETs [i.e., histones (H3), neutrophil elastase (NE), myeloperoxidase (MPO), pentraxin] via antibody-based immunofluorescence analyses...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28611585/role-of-n-arachidonoyl-serotonin-aa-5-ht-in-sleep-wake-cycle-architecture-sleep-homeostasis-and-neurotransmitters-regulation
#17
Eric Murillo-Rodríguez, Vincenzo Di Marzo, Sergio Machado, Nuno B Rocha, André B Veras, Geraldo A M Neto, Henning Budde, Oscar Arias-Carrión, Gloria Arankowsky-Sandoval
The endocannabinoid system comprises several molecular entities such as endogenous ligands [anandamide (AEA) and 2-arachidonoylglycerol (2-AG)], receptors (CB1 and CB2), enzymes such as [fatty acid amide hydrolase (FAHH) and monoacylglycerol lipase (MAGL)], as well as the anandamide membrane transporter. Although the role of this complex neurobiological system in the sleep-wake cycle modulation has been studied, the contribution of the blocker of FAAH/transient receptor potential cation channel subfamily V member 1 (TRPV1), N-arachidonoyl-serotonin (AA-5-HT) in sleep has not been investigated...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28610216/the-apseudomorpha-crustacea-tanaidacea-of-the-gulf-of-cadiz-and%C3%A2-horseshoe-continental-rise-ne-atlantic-a-taxonomic-review-with-new-records-species-and-ecological-data
#18
P Esquete, M R Cunha
The apseudomorphan tanaidaceans of the deep sea have been under-studied, especially in chemosynthetic habitats. A total of ten species present in the Gulf of Cadiz and the Horseshoe Continental Rise (SW off the Iberian Peninsula) are listed here, and new distribution data, ecological remarks and description of one new species of Atlantapseudes (Atlantapseudes curvatus sp. nov.) from recent research cruises are added. Pseudosphyrapus azorensis and Francapseudes uniarticulatus are recorded for the first time since the original descriptions...
June 9, 2017: Zootaxa
https://www.readbyqxmd.com/read/28610149/exceptionally-preserved-leptolepidae-actinopterygii-teleostei-from-the-late-early-jurassic-fossil-lagerst%C3%A3-tten-of-grimmen-and-dobbertin%C3%A2-mecklenburg-western-pomerania-germany
#19
Martin Konwert, Sebastian Stumpf
Exceptionally well-preserved fishes of the family Leptolepidae (Actinopterygii, Teleostei) from the late Early Jurassic Fossil-Lagerstätten of Grimmen and Dobbertin (Mecklenburg-Western Pomerania, NE Germany) are reported and detailed anatomical descriptions are given. The described material specifically derives from the "Green Series", which represents a specific facies that falls within the lower part of the early Toarcian Harpoceras falciferum ammonite Zone. Complete skeletons are rare, and most specimens are represented by isolated skulls...
March 15, 2017: Zootaxa
https://www.readbyqxmd.com/read/28609676/hepatocellular-differentiation-status-is-characterized-by-distinct-subnuclear-localization-and-form-of-the-chanzyme-trpm7
#20
Adenike Ogunrinde, Robyn D Pereira, Natalie Beaton, D Hung Lam, Christiane Whetstone, Ceredwyn E Hill
The channel-kinase TRPM7 is important for the survival, proliferation, and differentiation, of many cell types. Both plasma membrane channel activity and kinase function are implicated in these roles. Channel activity is greater in less differentiated hepatoma cells compared with non-dividing, terminally differentiated adult hepatocytes, suggesting differences in protein expression and/or localization. We used electrophysiological and immunofluorescence approaches to establish whether hepatocellular differentiation is associated with altered TRPM7 expression...
June 10, 2017: Differentiation; Research in Biological Diversity
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