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JOURNAL ARTICLE
Meghan R Hutch, Jiyeon Son, Trang T Le, Chuan Hong, Xuan Wang, Zahra Shakeri Hossein Abad, Michele Morris, Alba Gutiérrez-Sacristán, Jeffrey G Klann, Anastasia Spiridou, Ashley Batugo, Riccardo Bellazzi, Vincent Benoit, Clara-Lea Bonzel, William A Bryant, Lorenzo Chiudinelli, Kelly Cho, Priyam Das, Tomás González González, David A Hanauer, Darren W Henderson, Yuk-Lam Ho, Ne Hooi Will Loh, Adeline Makoudjou, Simran Makwana, Alberto Malovini, Bertrand Moal, Danielle L Mowery, Antoine Neuraz, Malarkodi Jebathilagam Samayamuthu, Fernando J Sanz Vidorreta, Emily R Schriver, Petra Schubert, Jeffery Talbert, Amelia L M Tan, Byorn W L Tan, Bryce W Q Tan, Valentina Tibollo, Patric Tippman, Guillaume Verdy, William Yuan, Paul Avillach, Nils Gehlenborg, Gilbert S Omenn, Shyam Visweswaran, Tianxi Cai, Yuan Luo, Zongqi Xia
Few studies examining the patient outcomes of concurrent neurological manifestations during acute COVID-19 leveraged multinational cohorts of adults and children or distinguished between central and peripheral nervous system (CNS vs. PNS) involvement. Using a federated multinational network in which local clinicians and informatics experts curated the electronic health records data, we evaluated the risk of prolonged hospitalization and mortality in hospitalized COVID-19 patients from 21 healthcare systems across 7 countries...
April 2024: PLOS Digit Health
#2
JOURNAL ARTICLE
Guohai Deng, Sebastian Hasenstab-Riedel
The trifluorosilylarsinidene F3SiAs in the triplet ground state has been generated through the reaction of laser-ablated silicon atoms with AsF3 in cryogenic Ne- and Ar-matrices. The reactions proceed with the initial formation perfluorinated arsasilene FAsSiF2 in the singlet ground state by two As‒F bonds insertion reaction on annealing. The trifluorosilylarsinidene F3SiAs was formed via F-migration reactions of FAsSiF2 under irradiation at UV light (λ = 275 nm). The characterization of FAsSiF2 and F3SiAs by IR matrix-isolation spectroscopy is supported by computations at CCSD(T)-F12/aug-cc-pVTZ and B3LYP/aug-cc-pVTZ levels of theory...
April 15, 2024: Chemistry: a European Journal
#3
JOURNAL ARTICLE
Yan Lu, Artur Wodyński, Marc Reimann, Robert Medel, Martin Kaupp, Sebastian Hasenstab-Riedel
The molecular IrF5-, IrF6- anions and M[IrF6] (M = Na-Cs) ion pairs were prepared by co-deposition of laser-ablated MF with IrF6 and isolated in solid Ne or Ar matrices. The free anions were obtained by co-deposition of IrF6 with laser-ablated metals (Ir, Pt) as electron sources. The products were characterized in a combined analysis of matrix IR spectroscopy and electronic structure calculations using two-component quasi-relativistic DFT methods accounting for scalar-relativistic and spin-orbit coupling effects as well as multi-reference configuration-interaction approaches with SOC...
April 15, 2024: Chemistry: a European Journal
#4
JOURNAL ARTICLE
Kyle K Obana, Morgan E Hasegawa, John D Mueller, Alexander N Berk, Julian B Rimm, Jonathan C Horng, Bryan M Saltzman, Robert L Parisien, Lorrin S K Lee, David P Trofa
BACKGROUND: Surfing is an increasingly popular sport with a high propensity for both traumatic and atraumatic injuries. PURPOSE: To analyze the trends, etiologies, and diagnoses of lower extremity orthopaedic-related surfing injuries presenting to United States (US) emergency departments (EDs) within a 21-year study period. STUDY DESIGN: Descriptive epidemiology study. METHODS: The National Electronic Injury Surveillance System database was queried for data on lower extremity surfing injuries presenting to US EDs from January 1 to December 31, 2022...
April 2024: Orthopaedic Journal of Sports Medicine
#5
JOURNAL ARTICLE
Tobias Else, Ka Kit Wong, Kirk A Frey, Allen F Brooks, Benjamin L Viglianti, David M Raffel
CONTEXT: Functional positron emission tomography (PET) imaging for the characterization of pheochromocytoma and paraganglioma (PCC/PGL) and for detection of metastases in malignant disease, offers valuable clinical insights that can significantly guide patient treatment. OBJECTIVE: This work aimed to evaluate a novel PET radiotracer, 3-[18 F]fluoro- para -hydroxyphenethylguanidine (3-[18 F]pHPG), a norepinephrine analogue, for its ability to localize PCC/PGL. METHODS: 3-[18 F]pHPG PET/CT whole-body scans were performed on 16 patients (8 male:8 female; mean age 47...
April 6, 2024: Journal of the Endocrine Society
#6
JOURNAL ARTICLE
Jinxiong Shi, Xiangyuan Zhao, Yunzhao Zhang, Yuchun You, Mohan Shang, Zhengping Zhu
Understanding the types, characteristics, and controlling factors of natural fractures in deep and ultradeep carbonates is crucial for evaluating reservoir quality, optimizing well deployment, and comprehending their impact on hydrocarbon exploitation. Multiple types of natural fractures are widespread in the deep carbonates of the Feixianguan Formation in the Puguang area, northeastern Sichuan Basin, China, and the main controlling factors are complex. Based on geological, geophysical, and experimental data, this study defined fracture types and analyzed the fracture development characteristics in the deep Feixianguan carbonates...
April 9, 2024: ACS Omega
#7
JOURNAL ARTICLE
Akansh Goal, Khadga Raj, Shamsher Singh, Rimpi Arora
Alzheimer's disease (AD) is a neurodegenerative disease that affects the neurons in the hippocampus, resulting in cognitive and memory impairment. The most prominent clinical characteristics of AD are the production of amyloid-beta (Aβ) plaques, neurofibrillary tangles, and neuroinflammation in neurons. It has been proven that embelin (Emb) possesses antioxidant, anti-inflammatory, and neuroprotective properties. Therefore, we assessed the therapeutic potential of Emb in Benzo [α]pyrene (BaP)-induced cognitive impairment in experimental mice...
2024: Current research in neurobiology
#8
JOURNAL ARTICLE
Kunal S Patel, Kaleab K Tessema, Riki Kawaguchi, Lindsey Dudley, Alvaro G Alvarado, Sree Deepthi Muthukrishnan, Travis Perryman, Akifumi Hagiwara, Vivek Swarup, Linda M Liau, Anthony C Wang, William Yong, Daniel H Geschwind, Ichiro Nakano, Steven A Goldman, Richard G Everson, Benjamin M Ellingson, Harley I Kornblum
BACKGROUND: Non-enhancing (NE) infiltrating tumor cells beyond the contrast-enhancing (CE) bulk of tumor are potential propagators of recurrence after gross total resection of high-grade glioma. METHODS: We leveraged single-nucleus RNA sequencing on 15 specimens from recurrent high-grade gliomas ( n = 5) to compare prospectively identified biopsy specimens acquired from CE and NE regions. Additionally, 24 CE and 22 NE biopsies had immunohistochemical staining to validate RNA findings...
2024: Neuro-oncology advances
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JOURNAL ARTICLE
Sungbo Cho, Santi Devi Upadhaya, Woo Jeong Seok, Seyoung Mun, Haeun Lee, Rudolf H van der Veen, Kyudong Han, In Ho Kim
Minerals is required small amounts among various nutrients, but it has a significant impact on sow longevity and reproduction performance. This study was carried out to see the beneficial effects of marine-derived Ca-Mg complex on the reproductive performance of sows during four-parity periods. Seventy-two gilts ([Yorkshire × Landrace] × Duroc), with an average body weight of 181 kg, were randomly allocated to three groups; CON (basal diet), 0.3LC (CON - MgO - 0.3% limestone + 0.4% Ca-Mg complex), and 0...
November 2023: Journal of Animal Science and Technology
#10
JOURNAL ARTICLE
Manon Badoux, José Damas, Isabel Cobos Manuel, Matthias Cavassini, Aline Munting
HIV pre-exposure prophylaxis (PrEP) is an effective tool in HIV prevention but is rarely prescribed by primary care physicians. A survey conducted among 147 physicians to assess their knowledge and interest in prescribing PrEP shows that 97% stated they have already heard of PrEP, but their knowledge of its indications, dosage, price, and side-effects is often incomplete or incorrect. For 69% of them, the main obstacle to prescribing PrEP is the lack of training on the subject. However, 70% of physicians express interest in receiving training to confidently prescribe PrEP to their patients...
April 10, 2024: Revue Médicale Suisse
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JOURNAL ARTICLE
Zachary J Sasiene, Glen P Jackson
RATIONALE: Charge transfer dissociation (CTD) is a novel fragmentation technique that demonstrates enhanced structural characterization for a wide variety of molecules compared to standard fragmentation techniques like collision-induced dissociation (CID). Alternative fragmentation techniques, such as electron transfer dissociation, electron capture dissociation, and ultraviolet photodissociation, also overcome many of the shortfalls of CID, but none of them are a silver bullet that can adequately characterize a wide variety of structures and charge states of target compounds...
June 30, 2024: Rapid Communications in Mass Spectrometry: RCM
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JOURNAL ARTICLE
Daniela Pastorim Vaiss, Jamile Lima Rodrigues, Virginia Campello Yurgel, Frank do Carmo Guedes, Lauanda Larissa Mendonça da Matta, Paula Alice Bezerra Barros, Gustavo Richter Vaz, Raíssa Nunes Dos Santos, Bibiana Franzen Matte, Larine Kupski, Jaqueline Garda-Buffon, Juliana Bidone, Ana Luiza Muccillo-Baisch, Fabio Sonvico, Cristiana Lima Dora
One of the most frequent causes of respiratory infections are viruses. Viruses reaching the airways can be absorbed by the human body through the respiratory mucosa and mainly infect lung cells. Several viral infections are not yet curable, such as coronavirus-2 (SARS-CoV-2). Furthermore, the side effect of synthetic antiviral drugs and reduced efficacy against resistant variants have reinforced the search for alternative and effective treatment options, such as plant-derived antiviral molecules. Curcumin (CUR) and quercetin (QUE) are two natural compounds that have been widely studied for their health benefits, such as antiviral and anti-inflammatory activity...
April 12, 2024: European Journal of Pharmaceutical Sciences
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JOURNAL ARTICLE
Remigius Gröning, Jonatan Walde, Clas Ahlm, Mattias Ne Forsell, Johan Normark, Johan Rasmuson
OBJECTIVES: To investigate the effectiveness of intravenous immunoglobulin (IVIG) as treatment for COVID-19 in immunocompromised patients. METHODS: This retrospective study investigated outcomes for immunocompromised, vaccine non-responsive, patients that between September 2022 and April 2023 received IVIG as treatment for COVID-19 in the region of Västerbotten, Sweden. We analyzed clinical data, viral load, and anti-SARS-CoV-2 IgG binding and neutralization levels of patient serum samples and IVIG production batches...
April 12, 2024: International Journal of Infectious Diseases: IJID
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REVIEW
Meghan G Hill
Neonatal encephalopathy (NE) is a diagnosis that is usually unexpected. Though there are many risk factors for the condition and multiple theories as to its genesis, the majority of cases cannot be predicted prior to the occurrence of the clinical syndrome. Indeed, it is common for a pregnant person to have multiple risk factors and a completely healthy child. Conversely, people with seemingly no risk factors may go on to have a profoundly affected child. In this synopsis we review risk factors, potential mechanisms for encephalopathy, the complicated issue of choosing which morbidity to take on and how the maternal level of care may influence outcomes...
April 10, 2024: Seminars in Fetal & Neonatal Medicine
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JOURNAL ARTICLE
Isuru Induruwa, Elizabeth Cattermole, Christopher Paisey, Colver Ken Howe Ne, Kayvan Khadjooi
Infection contributes to developing cardiac arrhythmias, such as atrial fibrillation (AF), which causes over 25% of ischaemic stroke. We analysed a hospital coding database of patients hospitalised with Coronavirus 2019 (COVID-19) ± AF or a lower respiratory tract infection (LRTI) ± AF, to compare the incidence of first-diagnosed or 'new' AF (nAF) between COVID-19 and LRTI, as well as risk factors associated with developing nAF during COVID-19. In total, 2,243 patients with LRTI and 488 patients with COVID-19 were included...
September 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#16
REVIEW
Maria M Moura, Andreia Monteiro, António J Salgado, Nuno A Silva, Susana Monteiro
Spinal Cord Injury (SCI) disrupts critical autonomic pathways responsible for the regulation of the immune function. Consequently, individuals with SCI often exhibit a spectrum of immune dysfunctions ranging from the development of damaging pro-inflammatory responses to severe immunosuppression. Thus, it is imperative to gain a more comprehensive understanding of the extent and mechanisms through which SCI-induced autonomic dysfunction influences the immune response. In this review, we provide an overview of the anatomical organization and physiology of the autonomic nervous system (ANS), elucidating how SCI impacts its function, with a particular focus on lymphoid organs and immune activity...
April 11, 2024: Neurobiology of Disease
#17
JOURNAL ARTICLE
Elisabeth Hempel, J Tyler Faith, Michaela Preick, Deon de Jager, Scott Barish, Stefanie Hartmann, José H Grau, Yoshan Moodley, Gregory Gedman, Kathleen Morrill Pirovich, Faysal Bibi, Daniela C Kalthoff, Sven Bocklandt, Ben Lamm, Love Dalén, Michael V Westbury, Michael Hofreiter
Low genomic diversity is generally indicative of small population size and is considered detrimental by decreasing long-term adaptability.1 , 2 , 3 , 4 , 5 , 6 Moreover, small population size may promote gene flow with congeners and outbreeding depression.7 , 8 , 9 , 10 , 11 , 12 , 13 Here, we examine the connection between habitat availability, effective population size (Ne ), and extinction by generating a 40× nuclear genome from the extinct blue antelope (Hippotragus leucophaeus). Historically endemic to the relatively small Cape Floristic Region in southernmost Africa,14 , 15 populations were thought to have expanded and contracted across glacial-interglacial cycles, tracking suitable habitat...
April 9, 2024: Current Biology: CB
#18
JOURNAL ARTICLE
Stina Becker, Aljoscha Swoboda, Henrik Siemer, Sandra Schimmelpfennig, Sarah Sargin, Victor Shahin, Albrecht Schwab, Karolina Najder
Neutrophil granulocytes play a crucial role in host defense against invading pathogens and in inflammatory diseases. The aim of this study was to elucidate membrane potential dynamics during the initial phase of neutrophil activation and its relation to migration and production of reactive oxygen species (ROS). We performed ROS production measurements of neutrophils from healthy C57BL/6J mice after TNFα-priming and/or C5a stimulation. The actin cytoskeleton was visualized with fluorescence microscopy...
April 13, 2024: Pflügers Archiv: European Journal of Physiology
#19
JOURNAL ARTICLE
Ziwei Ma, Yuming Yu, Ming Gao, Peng Chen, Huixia Hong, Dingle Yu, Zhenjiang Liang, Yu Bai, Qinlian Ye, Yachao Wang, Guodong Huang, Hui Tan
Depression is a common mental disorder. In recent years, more and more attention has been paid to depression and its etiology and pathogenesis. This review aims to explore the neuroprotective and antidepressant effects of hop components. By establishing an in vitro cell damage model using PC12 cells induced by corticosterone (CORT) and an in vivo depression model through the intracranial injection of lipopolysaccharide (LPS) in mice, hop ethyl acetate extract (HEA) was used to study the protective effect and mechanism of HEA on neuronal cells in vitro and the antidepression effect and mechanism in vivo...
April 13, 2024: ACS Chemical Neuroscience
#20
JOURNAL ARTICLE
Shannon H Clarke, Elizabeth R Lawrence, Jean-Michel Matte, Brian K Gallagher, Sarah J Salisbury, Sozos N Michaelides, Ramela Koumrouyan, Daniel E Ruzzante, James W A Grant, Dylan J Fraser
Effective population size (Ne ) is a particularly useful metric for conservation as it affects genetic drift, inbreeding and adaptive potential within populations. Current guidelines recommend a minimum Ne of 50 and 500 to avoid short-term inbreeding and to preserve long-term adaptive potential respectively. However, the extent to which wild populations reach these thresholds globally has not been investigated, nor has the relationship between Ne and human activities. Through a quantitative review, we generated a dataset with 4610 georeferenced Ne estimates from 3829 populations, extracted from 723 articles...
April 13, 2024: Molecular Ecology
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