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https://www.readbyqxmd.com/read/29330368/evidence-of-subtle-genetic-structure-in-the-sympatric-species-mullus-barbatus-and-mullus-surmuletus-linnaeus-1758-in-the-mediterranean-sea
#1
Sanja Matić-Skoko, Tanja Šegvić-Bubić, Ivana Mandić, David Izquierdo-Gomez, Enrico Arneri, Pierluigi Carbonara, Fabio Grati, Zdravko Ikica, Jerina Kolitari, Nicoletta Milone, Paolo Sartor, Giuseppe Scarcella, Adnan Tokaç, Evangelos Tzanatos
Using thirteen microsatellite loci for Mullus barbatus and Mullus surmuletus collected in the Mediterranean Sea, the biogeographic boundaries, genetic distribution among and within basins and the impact of prolonged exploitation in both species were investigated as a basis for understanding their population dynamics and for improving Mullus spp. stock management. Different level of diversity indices among these co-occurring species were obtained, with M. barbatus showing higher allele richness and higher mean observed and expected heterozygosity than M...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330204/pazopanib-exposure-relationship-with-clinical-efficacy-and-safety-in-the-adjuvant-treatment-of-advanced-renal-cell-carcinoma
#2
Cora Sternberg, Frede Donskov, Naomi B Haas, Christian Doehn, Paul Russo, Mohamed A Elmeliegy, Guillaume Baneyx, Hiya Banerjee, Paola Aimone, Robert J Motzer
PURPOSE: PROTECT, a phase III randomized placebo-controlled study, evaluated pazopanib efficacy and safety in the adjuvant RCC setting. The relationship between pazopanib exposure (Ctrough) and efficacy and safety was evaluated. EXPERIMENTAL DESIGN: Evaluable steady-state blood trough concentrations were collected from 311 patients at week 3 or 5 (early Ctrough), and 250 patients at week 16 or 20 (late Ctrough). Pazopanib pharmacokinetic (PK) data was analyzed via a population model approach...
January 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29329391/oxidative-burst-and-dectin-1-triggered-phagocytosis-affected-by-norepinephrine-and-endocannabinoids-implications-for-fungal-clearance-under-stress
#3
Judith-Irina Buchheim, Spencer Hoskyns, Dominique Moser, Bing Han, Elisabeth Deindl, Marion Hörl, Katharina Biere, Matthias Feuerecker, Gustav Schelling, Alexander Chouker
A prolonged stress burden is known to hamper the efficiency of both the innate and adaptive immune systems and to attenuate the stress responses by the catecholaminergic and endocannabinoid (EC) systems. Key mechanisms of innate immunity are the eradication of pathogens through phagocytosis and the respiratory burst. We tested the concentration-dependent, spontaneous and stimulated (via TNFα and fMLP) release of reactive oxygen species (ROS) by human PMNs in vitro in response to norepinephrine (NE) and AM1241, a pharmacological ligand for the endocannabinoid receptor CB2...
January 10, 2018: International Immunology
https://www.readbyqxmd.com/read/29328496/hypotension-risk-based-on-vasoactive-agent-discontinuation-order-in-patients-in-the-recovery-phase-of-septic-shock
#4
Gretchen L Sacha, Simon W Lam, Abhijit Duggal, Heather Torbic, Anita J Reddy, Seth R Bauer
STUDY OBJECTIVES: Patients with septic shock often require vasoactive agents for hemodynamic support; however, the optimal approach to discontinuing these agents once patients reach the recovery phase is currently unknown. The objective of this evaluation was to compare the incidence of hypotension within 24 hours based on the discontinuation order of norepinephrine (NE) and vasopressin (AVP) in patients in the recovery phase of septic shock. DESIGN: Retrospective cohort study...
January 12, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29324871/citrullinated-histone-h3-as-a-novel-prognostic-blood-marker-in-patients-with-advanced-cancer
#5
Charlotte Thålin, Staffan Lundström, Cedric Seignez, Maud Daleskog, Annika Lundström, Peter Henriksson, Thomas Helleday, Mia Phillipson, Håkan Wallén, Mélanie Demers
Citrullinated histone H3 (H3Cit) is a central player in the neutrophil release of nuclear chromatin, known as neutrophil extracellular traps (NETs). NETs have been shown to elicit harmful effects on the host, and were recently proposed to promote tumor progression and spread. Here we report significant elevations of plasma H3Cit in patients with advanced cancer compared with age-matched healthy individuals. These elevations were specific to cancer patients as no increase was observed in severely ill and hospitalized patients with a higher non-malignant comorbidity...
2018: PloS One
https://www.readbyqxmd.com/read/29324758/settlement-and-post-settlement-survival-rates-of-the-white-seabream-diplodus-sargus-in-the-western-mediterranean-sea
#6
Amalia Cuadros, Gotzon Basterretxea, Luis Cardona, Adrien Cheminée, Manuel Hidalgo, Joan Moranta
Survival during the settlement window is a limiting variable for recruitment. The survival is believed to be strongly determined by biological interactions and sea conditions, however it has been poorly investigated. We examined the settlement patterns related to relevant biotic and abiotic factors (i.e. Density-dependence, wind stress, wave height and coastal current velocity) potentially determining post-settler survival rates of a coastal necto-benthic fish of wide distribution in the Mediterranean and eastern Atlantic, the white seabream (Diplodus sargus)...
2018: PloS One
https://www.readbyqxmd.com/read/29321820/dysregulation-of-akt3-along-with-a-small-panel-of-mrnas-stratifies-high-grade-serous-ovarian-cancer-from-both-normal-epithelia-and-benign-tumor-tissues
#7
Pourya Naderi Yeganeh, Christine Richardson, Zahra Bahrani-Mostafavi, David L Tait, M Taghi Mostafavi
Screening methods of High-Grade Serous Ovarian Cancer (HGSOC) lack specificity and sensitivity, partly due to benign tumors producing false-positive findings. We utilized a differential expression analysis pipeline on malignant tumor (MT) and normal epithelial (NE) samples, and also filtered the results to discriminate between MT and benign tumor (BT). We report that a panel of 26 dysregulated genes stratifies MT from both BT and NE. We further validated our findings by utilizing unsupervised clustering methods on two independent datasets...
November 2017: Genes & Cancer
https://www.readbyqxmd.com/read/29321345/genetic-variability-and-structure-of-an-isolated-population-of-ambystoma-altamirani-a-mole-salamander-that-lives-in-the-mountains-of-one-of-the-largest-urban-areas-in-the-world
#8
Rosa-Laura Heredia-Bobadilla, Octavio Monroy-Vilchis, Martha M Zarco-González, Daniel Martínez-Gómez, Germán David Mendoza-Martínez, Armando Sunny
Amphibians are globally threatened by habitat loss and fragmentation; species within the order Ambystoma are not the exception, as there are 18 species of mole salamanders in México, of which 16 are endemic and all species are under some national or international status of protection. The mole salamander, Ambystoma altamirani is a microendemic species, which is distributed in central México, within the trans-Mexican volcanic belt, and is one of the most threatened species due to habitat destruction and the introduction of exotic species...
December 2017: Journal of Genetics
https://www.readbyqxmd.com/read/29320848/assessment-of-metal-immission-in-urban-environments-using-elemental-concentrations-and-zn-isotope-signatures-in-leaves-of-nerium-oleander
#9
Ana Martín, Cristina Caldelas, Dominik Jakob Weiss, Iker Aranjuelo, Enrique Navarro
A thorough understanding of spatial and temporal emission and immission patterns of air pollutants in urban areas is challenged by the low number of air quality monitoring stations available. Plants are promising low cost biomonitoring tools. However, source identification of the trace metals incorporated in plant tissues (i.e. natural vs. anthropogenic) and the identification of the best plant to use remain fundamental challenges. To this end, Nerium oleander L. collected in the city of Zaragoza (NE Spain) has been investigated as a biomonitoring tool for assessing the spatial immission patterns of airborne metals (Pb, Cu, Cr, Ni, Ce, and Zn)...
January 10, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29320726/pullulanase-treatments-to-increase-resistant-starch-content-of-black-chickpea-cicer-arietinum-l-starch-and-the-effects-on-starch-properties
#10
Hilal Demirkesen-Bicak, Zeynep Tacer-Caba, Dilara Nilufer-Erdil
This study aimed to increase resistant starch (RS) content of black chickpeas (Cicer arietinum L.) by using pullulanase enzyme. Physicochemical and functional properties of enzyme treated starch (NE) was compared with that of enzyme-treated and gelatinized starch (GE) and the retrograded control starch (RC). RS contents for native black chickpea starch (NS) and black chickpea flour (NF) were measured as 15.2% and 5.0%, respectively. While for NE and GE, were found as 16.4% and 12.3%, respectively. Treatments made on the NS, increased the amount of RDS and reduced the amount of SDS significantly (p < ...
January 7, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29319906/consequences-of-multiple-mating-system-shifts-for-population-and-range-wide-genetic-structure-in-a-coastal-dune-plant
#11
A López-Villalobos, C G Eckert
Evolutionary transitions from outcrossing to selfing can strongly affect the genetic diversity and structure of species at multiple spatial scales. We investigated the genetic consequences of mating system shifts in the North American, Pacific coast dune endemic plant Camissoniopsis cheiranthifolia (Onagraceae) by assaying variation at 13 nuclear (n) and six chloroplast (cp) microsatellite (SSR) loci for 38 populations across the species range. As predicted from the expected reduction of effective population size (Ne ) caused by selfing, small-flowered, predominantly selfing (SF) populations had much lower nSSR diversity (but not cpSSR) than large flowered, predominantly outcrossing (LF) populations...
January 10, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29317065/nature-exposure-sufficiency-and-insufficiency-the-benefits-of-environmental-preservation
#12
John R Reddon, Salvatore B Durante
Increasing industrialization, urbanization, and a failure of many world leaders to appreciate the consequences of climate change are deleteriously impacting quality of life as well as diminishing the prospects for long term survival. Economic competitiveness and corporate profitability often pre-empt environmental concerns. The calving of an iceberg in Antarctica and the hurricane activity in the Caribbean during 2017 are unfortunate illustrations of the continuing escalation of environmental issues. We provide historical and current evidence for the importance of Nature Exposure (NE) and introduce the continuum Nature Exposure Sufficiency (NES) and Insufficiency (NEI)...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29315303/genome-wide-comparison-of-ethiopian-leishmania-donovani-strains-reveals-differences-potentially-related-to-parasite-survival
#13
Arie Zackay, James A Cotton, Mandy Sanders, Asrat Hailu, Abedelmajeed Nasereddin, Alon Warburg, Charles L Jaffe
Leishmania donovani is the main cause of visceral leishmaniasis (VL) in East Africa. Differences between northern Ethiopia/Sudan (NE) and southern Ethiopia (SE) in ecology, vectors, and patient sensitivity to drug treatment have been described, however the relationship between differences in parasite genotype between these two foci and phenotype is unknown. Whole genomic sequencing (WGS) was carried out for 41 L. donovani strains and clones from VL and VL/HIV co-infected patients in NE (n = 28) and SE (n = 13)...
January 9, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29310473/a-new-approach-for-diagnosing-chronic-myelomonocytic-leukemia-using-structural-parameters-of-sysmex-xntm-analyzers-in-routine-laboratory-practice
#14
Françoise Schillinger, Elise Sourdeau, Marouane Boubaya, Lucile Baseggio, Sylvain Clauser, Edouard Cornet, Camille Debord, Jean-Pierre Defour, Frédérique Dubois, Marion Eveillard, Anne-Cécile Galoisy, Marie-Odile Geay, François Mullier, Vanessa Nivaggioni, Valérie Soenen, Pascal Morel, Francine Garnache-Ottou, Emily Ronez, Valérie Bardet, Eric Deconinck
According to WHO recommendations, diagnosis of chronic myelomonocytic leukemia (CMML) beforehand requires microscopic examination of peripheral blood to identify dysplasia and/or blasts when monocytes are greater or equal to 1.0 × 109/L and 10% of leucocytes. We analyzed parameters derived from SysmexTM XN analyzers to improve the management of microscopic examination for monocytosis. We analyzed results of the complete blood count and the positioning and dispersion parameters of polymorphonuclear neutrophils and monocytes in 61 patients presenting with CMML and 635 control patients presenting with a reactive monocytosis...
January 8, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29306782/the-formation-of-canine-neutrophil-extracellular-traps-induced-by-sodium-arsenic-in-polymorphonuclear-neutrophils
#15
Zhengkai Wei, Xu Zhang, Jingjing Wang, Yanan Wang, Zhengtao Yang, Yunhe Fu
As a novel defense effector mechanism of host innate immune system, neutrophil extracellular traps (NETs) plays an important role against pathogens infection and several diseases. In this study, we investigated the influence of sodium arsenic on novel effector mechanism of NETs generated by polymorphonuclear neutrophils (PMN) and the potential molecular mechanism. Sodium arsenic-induced NETs formation was observed by fluorescence confocal microscopy. Quantitation of NETs induced by sodium arsenic was determined by fluorescence microplate...
December 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29306286/sub-doppler-slit-jet-infrared-spectroscopy-of-astrochemically-relevant-cations-symmetric-%C3%AE-1-and-antisymmetric-%C3%AE-6-nh-stretching-modes-in-nd2h2
#16
Chih-Hsuan Chang, David J Nesbitt
Sub-Doppler infrared rovibrational transitions in the symmetric (v1) and antisymmetric (v6) NH stretch modes of the isotopomerically substituted ND2H2+ ammonium cation are reported for the first time in a slit jet discharge supersonic expansion spectrometer. The partially H/D substituted cation is generated by selective isotopic exchange of ND3 with H2O to form NHD2, followed by protonation with H3+ formed in the NHD2/H2/Ne slit-jet discharge expansion environment. Rotational assignment for ND2H2+ is confirmed rigorously by four line ground state combination differences, which agree to be within the sub-Doppler precision in the slit jet (∼9 MHz)...
January 7, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29305987/l-3-4-dihydroxyphenylalanine-l-dopa-induces-neuroendocrinological-physiological-and-immunological-regulation-in-white-shrimp-litopenaeus-vannamei
#17
Ratchaneegorn Mapanao, Hsin-Wei Kuo, Chin-Chuan Chang, Kuan-Fu Liu, Winton Cheng
L-3,4-Dihydroxyphenylalanine (l-DOPA) is a precursor for dopamine (DA) synthesis. Assessments were conducted to analyze the effects of l-DOPA on mediating regulation of neuroendocrinological, immunological, and physiological parameters in the shrimp, Litopenaeus vannamei when they were individually injected with 0.01 N HCl or l-DOPA at 0.5 or 1.0 μmol shrimp-1 for 60, 120, and 240 min. For catecholamine synthesis evaluation, tyrosine hydroxylase (TH) and DA beta hydroxylase (DBH) activities, l-DOPA, DA, and norepinephrine (NE) levels in hemolymph were determined...
January 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29305952/yield-and-bias-in-defining-a-cohort-study-baseline-from-electronic-health-record-data
#18
Jason L Vassy, Yuk-Lam Ho, Jacqueline Honerlaw, Kelly Cho, J Michael Gaziano, Peter W F Wilson, David R Gagnon
AIMS: Despite growing interest in using electronic health records (EHR) to create longitudinal cohort studies, the distribution and missingness of EHR data might introduce selection bias and information bias to such analyses. We aimed to examine the yield and potential for these healthcare process biases in defining a study baseline using EHR data, using the example of cholesterol and blood pressure (BP) measurements. METHODS: We created a virtual cohort study of cardiovascular disease (CVD) from patients with eligible cholesterol profiles in the New England (NE) and Southeast (SE) networks of the Veterans Health Administration in the United States...
January 3, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29305507/-evolution-of-a-dominant-natural-isolate-of-escherichia-coli-in-the-human-gut-over-a-year-suggests-a-neutral-evolution-with-reduced-effective-population-size
#19
Mohamed Ghalayini, Adrien Launay, Antoine Bridier-Nahmias, Olivier Clermont, Erick Denamur, Mathilde Lescat, Olivier Tenaillon
In vitro and in vivo evolution experiments on Escherichia coli revealed several principles of bacterial adaptation. However, few data are available in the literature describing the behavior of E. coli in its natural environment. We attempted here to study the evolution in the human gut of a commensal dominant E. coli clone ED1a belonging to B2 phylogroup, through a longitudinal genomic study. We sequenced 24 isolates sampled at three different time points within a healthy individual over almost a year. We computed amutation rate of 6...
January 5, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29305013/transcription-insights-from-the-hiv-1-promoter
#20
Enrico Ne, Robert-Jan Palstra, Tokameh Mahmoudi
In this review, we cover transcription regulation of human immunodeficiency virus type 1 (HIV-1) gene expression, focusing on the invaluable contributions, made by HIV research over the years, toward the field of transcription. In this context, the HIV promoter can be considered to be a well-studied model promoter, which although a viral promoter, is subject to the same cellular regulatory mechanisms that modulate the transcriptional control of endogenous host cellular genes. The molecular control of HIV-1 transcription has been well studied and considerable knowledge toward development of alternative strategies for therapies aimed at eradicating both active but also latent HIV-1 has been obtained...
2018: International Review of Cell and Molecular Biology
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