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https://www.readbyqxmd.com/read/28719070/sirtuin-1-attenuates-inflammation-and-hepatocellular-damage-in-liver-transplant-ischemia-reperfusion-from-mouse-to-human
#1
Kojiro Nakamura, Shoichi Kageyama, Bibo Ke, Takehiro Fujii, Rebecca A Sosa, Elaine F Reed, Nakul Datta, Ali Zarrinpar, Ronald W Busuttil, Jerzy W Kupiec-Weglinski
Hepatic ischemia-reperfusion injury (IRI), an inevitable antigen-independent inflammation response in cadaveric liver transplantation, correlates with poor early graft function, rejection episodes, and contributes to donor organ shortage. Sirtuin 1 (SIRT1) is a histone deacetylase which may regulate inflammatory cell activity and manage liver function in IRI, though its functional role and clinical relevance remains to be elucidated. We investigated the efficacy of SIRT1 activation in murine liver IRI model and verified the concept of putative SIRT1-mediated hepatoprotection in clinical liver transplantation...
July 18, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28715595/lifestyle-physical-activity-and-cognitive-functions-the-impact-on-the-scores-of-montreal-cognitive-assessment-moca
#2
A Innocenti, D M Cammisuli, D Sgromo, F Franzoni, J Fusi, F Galetta, C Pruneti
The Montreal Cognitive Assessment (MoCA) is a rapid screening tool, including subtests to assess several cognitive domains, developed to detect MCI from normal ageing cognitive changes. Several validation and normative studies have conducted around the world considering the influences of age and education on the MoCA score, but none takes into account the lifestyle and habits. However, lifestyles, and particularly physical activity (PA) have been positively associated with both physical and mental health in elderly...
July 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/28707959/interactions-of-the-salience-network-and-its-subsystems-with-the-default-mode-and-the-central-executive-networks-in-normal-aging-and-mild-cognitive-impairment
#3
Ganesh Chand, Junjie Wu, Ihab Hajjar, Deqiang Qiu
Previous functional MRI (fMRI) investigations suggest that the intrinsically organized large-scale networks and the interaction between them might be crucial for cognitive activities. A triple network model, which consists of the default-mode network, salience network, and central-executive network, has been recently employed to understand the connectivity patterns of the cognitively normal brains versus the brains with disorders. This model suggests that the salience network dynamically controls the default-mode and central-executive networks in healthy young individuals...
July 14, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28701890/relationship-between-oxidative-stress-physical-activity-and-vitamin-intake-in-patients-with-asthma
#4
Akira Yamasaki, Yuji Kawasaki, Kenichi Takeda, Tomoya Harada, Yasuyuki Hasegawa, Takehito Fukushima, Ryota Okazaki, Haruhiko Makino, Yoshihiro Funaki, Yuriko Sueda, Akihiro Yamamoto, Jun Kurai, Masanari Watanabe, Eiji Shimizu
BACKGROUND: Oxidative stress plays an important role in the pathogenesis of bronchial asthma. Antioxidant nutrition and supplementation have been used to reduce oxidative stress. However, a clinical trial with antioxidant supplementation showed no beneficial effects in patients with asthma. On the other hand, physical activity is related to the prognosis of chronic obstructive pulmonary disease (COPD) and is also related to oxidant status. We investigated the relationships between oxidative stress, serum levels of vitamins, dietary vitamin intake, daily activities, and pulmonary functions in patients with asthma...
June 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28695974/what-determine-the-quality-of-life-of-adult-patients-after-fontan-procedure
#5
Monika Smaś-Suska, Natalia Dłużniewska, Piotr Weryński, Jacek Pająk, Wojciech Płazak, Maria Olszowska, Piotr Podolec, Lidia Tomkiewicz-Pająk
BACKGROUND: Despite the low early mortality of Fontan procedures, Fontan patients are prone to various cardiac and extra-cardiac complications in the long term. This may influence patient perception of their health and outcome. The aim of the study was to assess the relationship of multi-organ complications and physical efficiency with self-reported health-related quality of life (QOL) in adult Fontan patients. METHODS: Quality of life was assessed with the Short Form-36 questionnaire...
July 11, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28694970/increasing-evidence-indicates-low-bioaccumulation-of-carbon-nanotubes
#6
Rhema Bjorkland, David Tobias, Elijah J Petersen
As the production of carbon nanotubes (CNTs) expands, so might the potential for release into the environment. The possibility of bioaccumulation and toxicological effects has prompted research on their fate and potential ecological effects. For many organic chemicals, bioaccumulation properties are associated with lipid-water partitioning properties. However, predictions based on phase partitioning provide a poor fit for nanomaterials. In the absence of data on the bioaccumulation and other properties of CNTs, the Office of Pollution Prevention and Toxics (OPPT) within the US Environmental Protection Agency (EPA) subjects new pre-manufacture submissions for all nanomaterials to a higher-level review...
2017: Environmental Science. Nano
https://www.readbyqxmd.com/read/28665377/-the-novel-approaches-to-the-rehabilitation-of-the-patients-presenting-with-gastroesophageal-reflux-disease-and-co-morbid-pathology
#7
N E Komleva, A A Marjanovsky, A N Danilov, L G Agasarov
This paper was designed to discuss the problems of co-morbidity and approaches to the rehabilitation of the patients presenting with gastroesophageal reflux disease and a concomitant pathology and to analyze the issues concerning the possible vertebro-visceral correlations inherent in the diseases of the internal organs. AIM: To evaluate the vertebro-neurological status of the thoracic segment of the vertebral column in the patients suffering from gastroesophageal reflux disease and to further improve the methods for their treatment taking into consideration the concomitant pathology, if any...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/28658055/appropriate-use-of-effective-dose-in-radiation-protection-and-risk-assessment
#8
Darrell R Fisher, Frederic H Fahey
Effective dose was introduced by the ICRP for the single, over-arching purpose of setting limits for radiation protection. Effective dose is a derived quantity or mathematical construct and not a physical, measurable quantity. The formula for calculating effective dose to a reference model incorporates terms to account for all radiation types, organ and tissue radiosensitivities, population groups, and multiple biological endpoints. The properties and appropriate applications of effective dose are not well understood by many within and outside the health physics profession; no other quantity in radiation protection has been more confusing or misunderstood...
August 2017: Health Physics
https://www.readbyqxmd.com/read/28643284/hydroxyl-radical-mediated-degradation-of-diclofenac-revisited-a-computational-approach-to-assessment-of-reaction-mechanisms-and-by-products
#9
Sesil Agopcan Cinar, Asu Ziylan-Yavaş, Saron Catak, Nilsun H Ince, Viktorya Aviyente
Advanced oxidation processes (AOPs) are based on the in situ production of hydroxyl radicals (•OH) and reactive oxygen species (ROS) in water upon irradiation of the sample by UV light, ultrasound, electromagnetic radiation, and/or the addition of ozone or a semiconductor. Diclofenac (DCF), one of the emerging organic contaminants (EOC), is of environmental concern due to its abundancy in water and is known to be subjected to AOPs. The current study uses density functional theory (DFT) to elucidate the mechanisms of the reactions between •OH and DCF leading to degradation by-products, P1-P9...
June 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28638938/-geriatric-case-management-at-the-kitchen-table-patient-outcome-of-the-pilot-project-for-a%C3%A2-regional-geriatric-care-concept-in-the-district-of-lippe
#10
Charlotte Şahin, Anja Rethmeier-Hanke, Olaf Iseringhausen, Constanze Liebe, Bernd Wedmann, Kira Hower
BACKGROUND: The interdisciplinary healthcare treatment of the elderly needs to consider their complex needs. There is a need for new structures of care to be tested, as in the model project regional geriatric care (RVG) concept. The aim is to qualitatively improve the treatment of elderly, multimorbid people by the implementation of case management and therefore to promote living in their own home and avoidance of the necessity for care. OBJECTIVE: How can the quality of care of a geriatric care concept be measured and the benefits for the target group be evaluated? MATERIALS AND METHODS: The explorative evaluation study reports patient outcomes for n = 380 participants who underwent geriatric assessment at the beginning of the intervention and again 12 months later...
June 20, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28637980/satisfaction-with-dietary-life-affects-oral-health-related-quality-of-life-and-subjective-well-being-in-very-elderly-people
#11
Toshimitsu Iinuma, Yasumichi Arai, Midori Takayama, Michiyo Takayama, Yukiko Abe, Yusuke Osawa, Motoko Fukumoto, Yusuke Fukui, Yohei Shioda, Nobuyoshi Hirose, Kazuo Komiyama, Nobuhito Gionhaku
Age-related deterioration in physical and oral health reduces healthy life expectancy and is thus an important problem for very elderly people. We investigated the effects of satisfaction with dietary life (SDL) in everyday life on oral health-related quality of life (OHRQoL) and subjective well-being and examined associations between these factors. We evaluated 426 elders aged 85 years or older. All participants completed a questionnaire that inquired about age, gender, drinking status, body mass index, cognitive function, disability, and comorbidities, among other covariates...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28632592/changes-in-psychological-status-and-health-related-quality-of-life-following-total-shoulder-arthroplasty
#12
Chul-Hyun Cho, Kwang-Soon Song, Ilseon Hwang, Margaret S Coats-Thomas, Jon J P Warner
BACKGROUND: There has been little documentation of the effects of total shoulder arthroplasty (TSA) on psychological status and health-related quality of life (HRQoL). We investigated changes in psychological status (depression and anxiety) and HRQoL following TSA and assessed the effect of preoperative psychological status on postoperative clinical and functional outcome. We hypothesized that TSA would improve both psychological status and HRQoL. METHODS: We prospectively enrolled 46 patients undergoing TSA for osteoarthritis...
June 21, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28628243/using-ultrahigh-resolution-mass-spectrometry-and-toxicity-identification-techniques-to-characterize-the-toxicity-of-oil-sands-process-affected-water-the-case-for-classical-naphthenic-acids
#13
Sarah A Hughes, Ashley Mahaffey, Bryon Shore, Josh Baker, Bruce Kilgour, Christine Brown, Kerry M Peru, John V Headley, Howard C Bailey
Previous assessments of oil sands process-affected water (OSPW) toxicity were hampered by lack of high-resolution analytical analysis, use of non-standard toxicity methods, and variability between OSPW samples. We integrated ultrahigh-resolution mass spectrometry with a Toxicity Identification Evaluation (TIE) approach to quantitatively identify the primary cause of acute toxicity of OSPW to rainbow trout (Oncorhynchus mykiss). The initial characterization of OSPW toxicity indicated that toxicity was associated with non-polar organic compounds, and toxicant(s) were further isolated within a range of discrete methanol fractions that were then subjected to Orbitrap mass spectrometry to evaluate the contribution of naphthenic acid (NA) fraction compounds to toxicity...
June 19, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28614181/cochleovestibular-gene-transfer-in-neonatal-mice-by-canalostomy
#14
Jing-Ying Guo, Yu-Ying Liu, Teng-Fei Qu, Zhe Peng, Jing Xie, Guo-Peng Wang, Shu-Sheng Gong
Impairments of the inner ear result in sensorineural hearing loss and vestibular dysfunction in humans. A large proportion of these disorders are congenital, and involve both auditory and vestibular systems. Therefore, genetic interventions to correct deficits must be administered during early developmental stages. In this study, we evaluated inner ear gene transfer in neonatal mice by canalostomy using an adeno-associated virus serotype 8 (AAV8) vector. AAV8 with the green fluorescence protein (GFP) gene was inoculated into the inner ear of the neonatal mice through the posterior semicircular canal (canalostomy)...
August 2, 2017: Neuroreport
https://www.readbyqxmd.com/read/28611945/pregnant-greek-women-may-have-a-higher-prevalence-of-iodine-deficiency-than-the-general-greek-population
#15
Eftychia G Koukkou, Ioannis Ilias, Irene Mamalis, Kostas B Markou
BACKGROUND: Adequate dietary iodine consumption, predicted via the urinary iodine concentration (UIC), is necessary for normal thyroid function and for the neurodevelopment of fetuses and neonates. The general population of Greece is considered to be iodine sufficient, but our preliminary findings suggest that Greek pregnant women are at risk of iodine deficiency. OBJECTIVE: Our aim was to estimate the thyroid function and UIC in a representative population of pregnant Greek women...
February 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28602772/urine-leakage-during-sexual-activity-among-ethnically-diverse-community-dwelling-middle-aged-and-older%C3%A2-women
#16
Nagambika Munaganuru, Stephen K Van Den Eeden, Jennifer Creasman, Leslee L Subak, Lisa Strano-Paul, Alison J Huang
BACKGROUND: Urinary incontinence is associated with decreased female sexual function, but little is known about the prevalence, predictors, and impact of urine leakage during sexual activity among women in the community. OBJECTIVE: The purpose of this study was to evaluate the prevalence and impact of urine leakage during sex in ethnically diverse, community-dwelling midlife and older women. STUDY DESIGN: Urinary incontinence and sexual function were assessed by structured questionnaire in a multiethnic, community-based cohort of women enrolled in Kaiser Permanente Northern California, an integrated healthcare delivery system in California...
June 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28597589/enhanced-decomposition-of-stable-soil-organic-carbon-and-microbial-catabolic-potentials-by-long-term-field-warming
#17
Wenting Feng, Junyi Liang, Lauren E Hale, Chang Gyo Jung, Ji Chen, Jizhong Zhou, Minggang Xu, Mengting Yuan, Liyou Wu, Rosvel Bracho, Elaine Pegoraro, Edward A G Schuur, Yiqi Luo
Quantifying soil organic carbon (SOC) decomposition under warming is critical to predict carbon-climate feedbacks. According to the substrate regulating principle, SOC decomposition would decrease as labile SOC declines under field warming, but observations of SOC decomposition under warming do not always support this prediction. This discrepancy could result from varying changes in SOC components and soil microbial communities under warming. This study aimed to determine the decomposition of SOC components with different turnover times after subjected to long-term field warming and/or root exclusion to limit C input, and to test whether SOC decomposition is driven by substrate lability under warming...
June 9, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28596270/timing-of-post-exercise-carbohydrate-protein-supplementation-roles-of-gastrointestinal-blood-flow-and-mucosal-cell-damage-on-gastric-emptying-in-humans
#18
Hideaki Kashima, Nao Harada, Kanae Miyamoto, Masaki Fujimoto, Chiaki Fujita, Masako Yamaoka Endo, Toshio Kobayashi, Akira Miura, Yoshiyuki Fukuba
It is well known that protein ingestion immediately after exercise greatly stimulates muscle protein synthesis during the post-exercise recovery phase. However, immediately after strenuous exercise, the gastrointestinal (GI) mucosa is frequently injured by hypoperfusion in the organ/tissue, possibly resulting in impaired GI function (e.g., gastric emptying; GE). The aim of this study was to examine the effect of GI blood flow on the GE rate. Eight healthy young subjects performed an intermittent supramaximal cycling exercise for 30 min, which consisted of a 120% VO2 peak for 20 s, followed by 20 W for 40 s...
June 8, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28584316/stress-at-the-place-of-work-and-cognitive-functions-among-women-performing-intellectual-work-during-peri-and-post-menopausal-period
#19
Mariusz Gujski, Jarosław Pinkas, Tomasz Juńczyk, Adrianna Pawełczak-Barszczowska, Dorota Raczkiewicz, Alfred Owoc, Iwona Bojar
OBJECTIVES: The analysis of the relationship between stress at work and results of cognitive functions amongst women, at peri- and post-menopausal age, performing intellectual work. MATERIAL AND METHODS: The study group included women, aged 45-66 years old, employed as intellectual workers. Research instruments were: the Montreal Cognitive Assessment; computer tests of the CNS Vital Signs; the Subjective Work Characteristics Questionnaire, and a questionnaire designed by the author...
March 27, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28578195/intensive-epidermal-adsorption-and-specific-venous-deposition-of-carboxyl-quantum-dots-in-zebrafish-early-life-stages
#20
Li Qiang Chen, Cheng Zhi Ding, Jian Ling
To properly assess the environmental risk of quantum dots (QDs), it is necessary to determine their fate in living organisms, including adsorption, distribution and bioaccumulation under representative environmental or physiological conditions. We comprehensively investigated the fate of QDs with carboxyl terminal functional groups (carboxyl-QDs) in zebrafish (Danio rerio) embryo and larvae subjected to either waterborne exposure or cardiovascular system microinjection. On waterborne exposure, carboxyl-QDs exhibited an intensive adsorption and accumulation in the chorion of embryos, and their predominate target organs were the gill and intestinal tract in larvae...
May 31, 2017: Chemosphere
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