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subjective organ function assessment

Ross Parry, Olivier Buttelli, Jacques Riff, Narjis Sellam, Marie Vidailhet, Marie-Laure Welter, Elodie Lalo
PURPOSE: This study sought to characterize the way patients with Parkinson's disease consciously perceive and respond to their surroundings while walking in everyday situations. METHOD: A qualitative research program designed around an ecological data collection protocol was employed. A convenience sample of 14 patients with a diagnosis of Parkinson's disease and a history of gait difficulties were recruited. Details regarding patients' subjective experience of walking in everyday environments were obtained using first person interviewing techniques with the support of video footage from their daily-life activity...
June 19, 2018: Disability and Rehabilitation
Janine McCaughey, David J Stephens
The export of newly synthesized proteins from the endoplasmic reticulum is fundamental to the ongoing maintenance of cell and tissue structure and function. After co-translational translocation into the ER, proteins destined for downstream intracellular compartments or secretion from the cell are sorted and packaged into transport vesicles by the COPII coat protein complex. The fundamental discovery and characterization of the pathway has now been augmented by a greater understanding of the role of COPII in diverse aspects of cell function...
June 18, 2018: Histochemistry and Cell Biology
Mustafa Tahtaci, Huseyin Koseoglu, Murat Alisik, Oyku Tayfur Yurekli, Gozde Tahtaci, Ozcan Erel, Osman Ersoy
Non-ulcer dyspepsia (NUD) is a term used to define a set of symptoms that are believed to originate from the gastroduodenal region, and no underlying organic, systemic, or metabolic reason can be found. The majority of patients suffer from chronic symptoms although half of the patients report improvement in symptoms with time. The potential role exocrine pancreatic insufficiency in NUD patients has not been clarified yet. We aimed to identify exocrine pancreas function with pancreatic fecal elastase-1 in patients diagnosed with non-ulcer dyspepsia and no typical exocrine pancreatic insufficiency (EPI) symptoms...
June 16, 2018: Journal of Clinical Medicine
Marcin Kunecki, Tomasz Roleder, Jolanta Biernat, Paweł Kukla, Lidia Tomkiewicz-Pająk, Marek A Deja, Piotr Podolec, Krzysztof S Gołba, Wojciech Płazak
BACKGROUND: Opioidergic conditioning is well documented to trigger cardioprotection against ischemia/ reperfusion (I/R) injury. Previous studies on animal models have suggested that nitric oxide (NO) mediates the beneficial effect of opioids, but the role of NO in humans seems to be controversial. OBJECTIVES: The aim of the study was to assess the influence of NO modulators on opioid-induced cardioprotection in the human myocardium. MATERIAL AND METHODS: Trabeculae of the human right atria were electrically driven in an organ bath and subjected to simulated I/R injury...
June 18, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
L Eichhorn, J Doerner, J A Luetkens, J M Lunkenheimer, R C Dolscheid-Pommerich, F Erdfelder, R Fimmers, J Nadal, B Stoffel-Wagner, H H Schild, A Hoeft, B Zur, C P Naehle
BACKGROUND: Prolonged breath holding results in hypoxemia and hypercapnia. Compensatory mechanisms help maintain adequate oxygen supply to hypoxia sensitive organs, but burden the cardiovascular system. The aim was to investigate human compensatory mechanisms and their effects on the cardiovascular system with regard to cardiac function and morphology, blood flow redistribution, serum biomarkers of the adrenergic system and myocardial injury markers following prolonged apnoea. METHODS: Seventeen elite apnoea divers performed maximal breath-hold during cardiovascular magnetic resonance imaging (CMR)...
June 18, 2018: Journal of Cardiovascular Magnetic Resonance
Lorenzo Carnevale, Valentina D'Angelosante, Alessandro Landolfi, Giovanni Grillea, Giulio Selvetella, Marianna Storto, Giuseppe Lembo, Daniela Carnevale
Aims: Hypertension is one of the main risk factor for dementia. The subtle damage provoked by chronic high blood pressure in the brain is usually evidenced by conventional magnetic resonance imaging (MRI), in terms of white matter (WM) hyperintensities or cerebral atrophy. However, it is clear that by the time brain damage is visible, it may be too late hampering neurodegeneration. Aim of this study was to characterize a signature of early brain damage induced by hypertension, before the neurodegenerative injury manifests...
June 12, 2018: Cardiovascular Research
Abdelnaby Khalyfa, David Gozal, Juan F Masa, José Maria Marin, Zhuanghong Qiao, Jaime Corral, Mónica González, Sergi Marti, Leila Kheirandish-Gozal, Carlos Egea, M-Ángeles Sánchez-Quiroga, Francisco J Gómez de Terreros, F Javier Barca
BACKGROUND: Sleep-disordered-breathing (SDB), which is characterized by chronic intermittent hypoxia (IH) and sleep fragmentation (SF), is a prevalent condition that promotes metabolic dysfunction, particularly among patients suffering from obstructive hypoventilation syndrome (OHS). Exosomes are generated ubiquitously, are readily present in the circulation, and their cargo may exert substantial functional cellular alterations in both physiological and pathological conditions. However, the effects of plasma exosomes on adipocyte metabolism in patients with OHS or in mice subjected to IH or SF mimicking SDB are unclear...
June 11, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
A Vania Apkarian
This focus article addresses the issue of the proper use of terminology in pain research. A review and some revisions on the definitions of pain and nociception, in relation to consciousness is presented. From a behavioral viewpoint, it is argued that pain is a conscious assessment of the failure of the organism to protect the body from injury (actual or potential); while continuously-ongoing sub/pre-conscious nociceptive processes protect the body from injuries. Thus, pain perception/behavior requires a subjective ability to evaluate the environment and form coordinated responses...
June 8, 2018: Journal of Pain: Official Journal of the American Pain Society
Brandie D Wagner, Gary K Grunwald, Gary O Zerbe, Susan K Mikulich-Gilbertson, Charles E Robertson, Edith T Zemanick, J Kirk Harris
Identification of the majority of organisms present in human-associated microbial communities is feasible with the advent of high throughput sequencing technology. As substantial variability in microbiota communities is seen across subjects, the use of longitudinal study designs is important to better understand variation of the microbiome within individual subjects. Complex study designs with longitudinal sample collection require analytic approaches to account for this additional source of variability. A common approach to assessing community changes is to evaluate the change in alpha diversity (the variety and abundance of organisms in a community) over time...
2018: Frontiers in Microbiology
Weiyang He, Shaojun Ye, Cheng Zeng, Shuai Xue, Xiaoyan Hu, Xingjian Zhang, Siqi Gao, Yan Xiong, Xueyu He, Soatina Vivalda, Ling Li, Yanfeng Wang, Qifa Ye
Hypothermic oxygenated perfusion (HOPE) is a relatively new dynamic preservation procedure that has not been widely implemented in liver transplantation despite its advantages. Improved graft protection is one such advantage offered by HOPE and has been attributed to multiple mechanisms, one of which may be the modulation of the thioredoxin-interacting protein (TXNIP)/NOD-like receptor protein 3 (NLRP3) inflammasome pathway. The TXNIP/NLRP3 inflammasome pathway plays a critical role in sterile inflammation under oxidative stress as a result of ischemia/reperfusion injury (IRI)...
June 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
J D Mendola, J Lam, M Rosenstein, L B Lewis, A Shmuel
Amblyopia is a prevalent developmental visual disorder of childhood that typically persists in adults. Due to altered visual experience during critical periods of youth, the structure and function of adult visual cortex is abnormal. In addition to substantial deficits shown with task-based fMRI, previous studies have used resting state measures to demonstrate altered long-range connectivity in amblyopia. This is the first study in amblyopia to analyze connectivity between regions of interest that are smaller than a single cortical area and to apply partial correlation analysis to reduce network effects...
2018: NeuroImage: Clinical
Z Mahmooth, W M Weiss, G A S Zangana, P Bolton
Background: Common mental health problems experienced by survivors of systematic violence include trauma, depression, and anxiety. A trial of mental health interventions by community mental health workers for survivors of systematic violence in southern Iraq showed benefits from two psychotherapies on trauma, depression, anxiety, and function: Common Elements Treatment Approach (CETA) and cognitive processing therapy (CPT). This study assessed whether other non-predetermined changes reported by intervention participants were more common than in the control group...
2018: Global Mental Health
Malou D Menting, Cornelieke van de Beek, Susanne R de Rooij, Rebecca C Painter, Tanja G M Vrijkotte, Tessa J Roseboom
The prevalence of obesity among women of childbearing age has been rising dramatically over the last decades. Pre-pregnancy obesity may have negative neurodevelopmental consequences for the offspring. The present study examined the association of maternal pre-pregnancy overweight and obesity with child behavior problems and executive functioning at age 5 years. Data of 4094 mother-child pairs of the Amsterdam Born Children and their Development birth cohort study was used. Child behavioral problems were assessed with the maternal and teacher version of the Strengths and Difficulties Questionnaire...
June 1, 2018: Early Human Development
Isabel Morales-Muñoz, Seppo Koskinen, Timo Partonen
BACKGROUND: Sleep problems are commonly reported in seasonal affective disorder (SAD) and major depressive disorder (MDD). However, the specific characteristics of sleep difficulties differ. Frequent sleep problems in MDD are insomnia and night awakenings, whereas SAD patients complain of hypersomnia and daytime sleepiness. No previous studies have reported differences in sleep functioning between these two disorders. METHODS: We interviewed 4554 subjects from the Health 2011 survey and included 4153 individuals in this study...
April 25, 2018: Sleep Medicine
Rémi Patriat, Scott E Cooper, Yuval Duchin, Jacob Niederer, Christophe Lenglet, Joshua Aman, Michael C Park, Jerrold L Vitek, Noam Harel
The success of deep brain stimulation (DBS) surgeries for the treatment of movement disorders relies on the accurate placement of an electrode within the motor portion of subcortical brain targets. However, the high number of electrodes requiring relocation indicates that today's methods do not ensure sufficient accuracy for all patients. Here, with the goal of aiding DBS targeting, we use 7 Tesla (T) MRI data to identify the functional territories and parcellate the globus pallidus pars interna (GPi) into motor, associative and limbic regions in individual subjects...
May 19, 2018: NeuroImage
Florian Büther, Iris Ernst, Lynn Johann Frohwein, Joost Pouw, Klaus Peter Schäfers, Lars Stegger
PURPOSE: Data-driven gating (DDG) approaches for positron emission tomography (PET) are interesting alternatives to conventional hardware-based gating methods. In DDG, the measured PET data themselves are utilized to calculate a respiratory signal that is subsequently used for gating purposes. The success of gating is then highly dependent on the statistical quality of the PET data. In this study we investigate how this quality determines signal noise and thus motion resolution in clinical PET scans using a center-of-mass-based (COM) DDG approach, specifically with regard to motion management of target structures in future radiotherapy planning applications...
May 21, 2018: Medical Physics
Tung Nguyen Thanh Uong, Kyung-Hwa Lee, Sung-Ja Ahn, Kyung Won Kim, Jung-Joon Min, Hoon Hyun, Mee Sun Yoon
Introduction: Ex vivo -expanded natural killer (NK) cells are a potential candidate for cancer immunotherapy based on high cytotoxicity against malignant tumor cells. However, a limited understanding of the migration of activated NK cells toward solid tumors is a critical dilemma in the development of effective and adoptive NK cell-based immunotherapy. Methods: Ex vivo -expanded NK cells from healthy donors were stained with near-infrared fluorophores at different concentrations...
2018: Frontiers in Immunology
Bo La Han, Qiunong Guan, Irina Chafeeva, Asher A Mendelson, Gerald da Roza, Richard Liggins, Jayachandran N Kizhakkedathu, Caigan Du
Metabolic syndrome (MetS) is commonly observed among peritoneal dialysis (PD) patients, and hyperbranched polyglycerol (HPG) is a promising glucose-sparing osmotic agent for PD. However, the biocompatibility of a HPG-based PD solution (HPG) in subjects with MetS has not been investigated. This study compared the local and systemic effects of a HPG solution with conventional Physioneal (PYS) and Icodextrin (ICO) PD solutions in rats with MetS. Obese type 2 diabetic ZSF1 rats received a daily intraperitoneal injection of PD solutions (10 mL) for 3 months...
May 12, 2018: Basic & Clinical Pharmacology & Toxicology
Dong Wook Shin, Hyun Sik Park, Sang Hyub Lee, Seung Hyun Jeon, Seok Cho, Seok Ho Kang, Seung Chol Park, Jong Hyock Park, Jinsung Park
Purpose: The purpose of this study was to compare health-related quality of life (HRQoL) of disease-free prostate (PC), kidney (KC), and bladder cancer (BC) survivors with that of the general population. Materials and Methods: Our study included 331 urological cancer (UC) survivors (114 PC, 108 KC, and 109 BC) aged ≥ 50 years disease-free for at least 1 year after surgery. The control group included 1,177 subjects without a history of cancer. The HRQoL was assessed using the European Organization for Research and Treatment of Cancer QLQ-C30, the Duke-UNC Functional Social Support Questionnaire, and the Patient Health Questionnaire-9...
May 4, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Rita Wedeking, Mickaël Maucourt, Catherine Deborde, Annick Moing, Yves Gibon, Heiner E Goldbach, Monika A Wimmer
Yield formation in regions with intermittent drought periods depends on the plant's ability to recover after cessation of the stress. The present work assessed differences in metabolic recovery of leaves and roots of drought-stressed sugar beets with high temporal resolution. Plants were subjected to drought for 13 days, and rewatered for 12 days. At one to two-day intervals, plant material was harvested for untargeted 1H-NMR metabolomic profiling, targeted analyses of hexose-phosphates, starch, amino acids, nitrate and proteins, and physiological measurements including relative water content, osmotic potential, electrolyte leakage and malondialdehyde concentrations...
2018: PloS One
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