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Prevention aorta dilatation

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https://www.readbyqxmd.com/read/27761202/novel-echocardiographic-indices-for-assessing-the-left-main-coronary-artery-in-children-with-kawasaki-disease
#1
Elaheh Malakan Rad, Iran Malekzadeh, Vahid Ziaee, Raheleh Rajabi, Zohreh Shahabi
BACKGROUND: Kawasaki disease (KD) is the most common cause of acquired myocardial infarction in children. Coronary artery involvement is the most serious feature of this vasculitis syndrome. Timely diagnosis of coronary artery involvement is of utmost importance since it can prevent long-term morbidity and mortality. The current methods for the diagnosis of coronary artery dilation in KD are inconsistent and are also not capable of detecting all the abnormal coronary arteries or the so-called occult dilations present...
August 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/27754285/me-04-3-epidemiology-and-consequences-of-early-vascular-aging
#2
Junichiro Hashimoto
Arterial structure and function change progressively with advancing age. Owing to long-lasting repetitive stretch with intermittent cardiac contraction, elastic fibers in the tunica media of large arteries gradually degenerate and are replaced by collagenous fibers. Such medial degeneration causes elastic arteries to stiffen and dilate. However, the speed of the vascular aging varies considerably among individuals; a discrepancy often exists between the chronological age of an individual and the biological age of his or her arteries...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27670594/calorie-restriction-protects-against-experimental-abdominal-aortic-aneurysms-in-mice
#3
Yue Liu, Ting-Ting Wang, Ran Zhang, Wen-Yan Fu, Xu Wang, Fang Wang, Peng Gao, Yang-Nan Ding, Yan Xie, De-Long Hao, Hou-Zao Chen, De-Pei Liu
Abdominal aortic aneurysm (AAA), characterized by a localized dilation of the abdominal aorta, is a life-threatening vascular pathology. Because of the current lack of effective treatment for AAA rupture, prevention is of prime importance for AAA management. Calorie restriction (CR) is a nonpharmacological intervention that delays the aging process and provides various health benefits. However, whether CR prevents AAA formation remains untested. In this study, we subjected Apoe(-/-) mice to 12 wk of CR and then examined the incidence of angiotensin II (AngII)-induced AAA formation...
October 17, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27643283/me-04-3-epidemiology-and-consequences-of-early-vascular-aging
#4
Junichiro Hashimoto
Arterial structure and function change progressively with advancing age. Owing to long-lasting repetitive stretch with intermittent cardiac contraction, elastic fibers in the tunica media of large arteries gradually degenerate and are replaced by collagenous fibers. Such medial degeneration causes elastic arteries to stiffen and dilate. However, the speed of the vascular aging varies considerably among individuals; a discrepancy often exists between the chronological age of an individual and the biological age of his or her arteries...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27619672/d-series-resolvins-inhibit-murine-abdominal-aortic-aneurysm-formation-and-increase-m2-macrophage-polarization
#5
Nicolas H Pope, Morgan Salmon, John P Davis, Anuran Chatterjee, Gang Su, Michael S Conte, Gorav Ailawadi, Gilbert R Upchurch
The role of resolvins in abdominal aortic aneurysm (AAA) has not been established. We hypothesized that treatment with D-series resolvins (RvD2 or RvD1) would attenuate murine AAA formation through alterations in macrophage polarization and cytokine expression. Male C57/B6 mice (n = 9 per group) 8 to 12 wk old received RvD2 (100 ng/kg/treatment), RvD1 (100 ng/kg/treatment), or vehicle only every third day beginning 3 d before abdominal aortic perfusion with elastase as prevention. Aortas were collected 14 d after elastase perfusion...
December 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27563552/when-and-how-to-replace-the-aortic-arch-for-type-a-dissection
#6
Roberto Di Bartolomeo, Alessandro Leone, Luca Di Marco, Davide Pacini
Acute type A aortic dissection (AAAD) remains one of the most challenging diseases in cardiothoracic surgery and despite numerous innovations in medical and surgical management, early mortality remains high. The standard treatment of AAAD requires emergency surgery of the proximal aorta, preventing rupture and consequent cardiac tamponade. Resection of the primary intimal tear and repair of the aortic root and aortic valve are well-established surgical principles. However, the dissection in the aortic arch and descending untreated aorta remains...
July 2016: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27550511/aortic-events-in-a-nationwide-marfan-syndrome-cohort
#7
Kristian A Groth, Kirstine Stochholm, Hanne Hove, Kasper Kyhl, Pernille A Gregersen, Niels Vejlstrup, John R Østergaard, Claus H Gravholt, Niels H Andersen
BACKGROUND: Marfan syndrome is associated with morbidity and mortality due to aortic dilatation and dissection. Preventive aortic root replacement has been the standard treatment in Marfan syndrome patients with aortic dilatation. In this study, we present aortic event data from a nationwide Marfan syndrome cohort. METHOD: The nationwide cohort of Danish Marfan syndrome patients was established from the Danish National Patient Registry and the Cause of Death Register, where we retrieved information about aortic surgery and dissections...
August 22, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27392820/protective-effect-of-melatonin-on-the-development-of-abdominal-aortic-aneurysm-in-a-rat-model
#8
Li Tang, Zhuangzhuang Cong, Shuangying Hao, Peng Li, Hairong Huang, Yi Shen, Kuanyu Li, Hua Jing
BACKGROUND: Oxidative injury, inflammation, and apoptosis are involved in the progression of abdominal aortic aneurysm (AAA). Melatonin (MLT) has been reported with an effective antioxidant activity. The objective of the present study was to investigate whether MLT could suppress the development of AAA. METHODS: The AAA model was introduced by intraluminal perfusion of elastase in rats. All rats were divided into three groups as follows: (1) sham; (2) AAA + vehicle; and (3) AAA + MLT...
June 16, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27389586/epigenetic-regulation-of-tgf-%C3%AE-1-signalling-in-dilative-aortopathy-of-the-thoracic-ascending-aorta
#9
REVIEW
Amalia Forte, Umberto Galderisi, Marilena Cipollaro, Marisa De Feo, Alessandro Della Corte
The term 'epigenetics' refers to heritable, reversible DNA or histone modifications that affect gene expression without modifying the DNA sequence. Epigenetic modulation of gene expression also includes the RNA interference mechanism. Epigenetic regulation of gene expression is fundamental during development and throughout life, also playing a central role in disease progression. The transforming growth factor β1 (TGF-β1) and its downstream effectors are key players in tissue repair and fibrosis, extracellular matrix remodelling, inflammation, cell proliferation and migration...
August 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27358138/elevated-expression-of-runt-related-transcription-factors-in-human-abdominal-aortic-aneurysm
#10
J Dubis, M Litwin, D Michalowska, N Zuk, A Szczepanska-Buda, R Grendziak, D Baczynska, P Barc, W Witkiewicz
Abdominal aortic aneurysm (AAA) is a multifactorial disease of unknown etiology. AAA is caused by segmental weakening of the aortic walls and progressive aortic dilation leading to the eventual rupture of the aorta, accompanied by intense inflammation. Additionally, studies have indicated a close relationship between the pathogenesis and progression of AAA and cellular immune responses in aneurysm wall tissue. The Runt-related genes (RUNX) encode multifunctional mediators of the of intracellular signal transduction pathways in vascular remodeling, endothelial function, immune response and inflammation...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27339495/progressive-aortic-dilation-is-regulated-by%C3%A2-mir-17-associated-mirnas
#11
Jie Wu, Hui-Fang Song, Shu-Hong Li, Jian Guo, Katherine Tsang, Laura Tumiati, Jagdish Butany, Terrence M Yau, Maral Ouzounian, Songbin Fu, Tirone E David, Richard D Weisel, Ren-Ke Li
BACKGROUND: Patients with a bicuspid aortic valve (BAV) are at increased risk for progressive aortic dilation associated with extracellular matrix (ECM) degradation by matrix metalloproteinases (MMP). However, the mechanisms responsible for initiating this process are unknown. In the heart, MMP activity is regulated by micro-ribonucleic acid-17 (miR-17)-related downregulation of tissue inhibitors of metalloproteinases (TIMP); a similar process may exist in the aorta. OBJECTIVES: This study sought to ascertain whether aortic matrix degradation in BAV patients progresses by miR-17-related miRNA regulation of TIMP-MMP...
June 28, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27333787/baicalein-protects-against-the-development-of-angiotensin-ii-induced-abdominal-aortic-aneurysms-by-blocking-jnk-and-p38-mapk-signaling
#12
Fang Wang, Houzao Chen, Yunfei Yan, Yue Liu, Shuyang Zhang, Depei Liu
An abdominal aortic aneurysm (AAA) is a permanent, localized dilatation of the abdominal aorta. In western countries, the morbidity of AAA is approximately 8%. Currently, pharmacotherapies for AAA are limited. Here, we demonstrate that baicalein (BAI), the main component of the Chinese traditional drug "Huang Qin", attenuates the incidence and severity of AAA in Apoe (-/-) mice infused with angiotensin II (AngII). Mechanically, BAI treatment decreases AngII-induced reactive oxygen species (ROS) production in the aortic wall...
September 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27175814/contemporary-management-of-type-b-aortic-dissection-in-the-endovascular-era
#13
Mohsen Bannazadeh, Rami O Tadros, James McKinsey, Rajiv Chander, Michael L Marin, Peter L Faries
Aortic dissection (AD) is one of the most common catastrophic pathologies affecting the aorta. Anatomic classification is based on the origin of entry tear and its extension. Type A dissections originate in the ascending aorta, whereas the entry tear in Type B dissections starts distal to the left subclavian artery. The patients with aortic dissection who manifest complications such as rupture, malperfusion, aneurysmal degeneration, and intractable pain are classified as complicated AD. Risk factors for developing aortic dissection include age, male gender, and aortic wall structural abnormalities...
April 2016: Surgical Technology International
https://www.readbyqxmd.com/read/27156641/association-between-thoracic-aorta-calcium-and-thoracic-aorta-geometry-in-a-cohort-of-asymptomatic-participants-at-increased-cardiovascular-risk
#14
Damian Craiem, Jean-Marc Alsac, Mariano E Casciaro, Salma El Batti, Elie Mousseaux, Marie-Emmanuelle Sirieix, Alain Simon
INTRODUCTION AND OBJECTIVES: Thoracic aorta calcium detection is known to improve cardiovascular risk prediction for cardiac and noncardiac events beyond traditional risk factors. We investigated the influence of thoracic aorta morphometry on the presence and extent of aortic calcifications. METHODS: Nonenhanced computed tomography heart scans were performed in 970 asymptomatic participants at increased cardiovascular risk. An automated algorithm estimated the geometry of the entire thoracic aorta and quantified the aortic calcium Agatston score...
September 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27089918/down-regulation-of-fibulin-5-is-associated-with-aortic-dilation-role-of-inflammation-and-epigenetics
#15
Mar Orriols, Saray Varona, Ingrid Martí-Pàmies, María Galán, Anna Guadall, José Román Escudero, José Luis Martín-Ventura, Mercedes Camacho, Luis Vila, José Martínez-González, Cristina Rodríguez
AIMS: Destructive remodelling of extracellular matrix (ECM) and inflammation lead to dilation and ultimately abdominal aortic aneurysm (AAA). Fibulin-5 (FBLN5) mediates cell-ECM interactions and elastic fibre assembly and is critical for ECM remodelling. We aimed to characterize FBLN5 regulation in human AAA and analyse the underlying mechanisms. METHODS AND RESULTS: FBLN5 expression was significantly decreased in human aneurysmatic aortas compared with healthy vessels...
June 1, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27079253/11-12-epoxyecosatrienoic-acids-mitigate-endothelial-dysfunction-associated-with-estrogen-loss-and-aging-role-of-membrane-depolarization
#16
Chongxiu Sun, Scott I Simon, Greg A Foster, Christopher E Radecke, HyunTae V Hwang, Xiaodong Zhang, Bruce D Hammock, N Chiamvimonvat, Anne A Knowlton
OBJECTIVE: Endothelial dysfunction, including upregulation of inflammatory adhesion molecules and impaired vasodilatation, is a key element in cardiovascular disease. Aging and estrogen withdrawal in women are associated with endothelial inflammation, vascular stiffness and increased cardiovascular disease. Epoxyecosatrienoic acids (EETs), the products of arachidonic acid metabolism mediated by cytochrome P450 (CYP) 2J, 2C and other isoforms, are regulated by soluble epoxide hydrolase (sEH)-catalyzed conversion into less active diols...
May 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27022887/the-preventive-effect-of-fish-oil-on-abdominal-aortic-aneurysm-development
#17
Hirona Kugo, Nobuhiro Zaima, Youhei Mouri, Hiroki Tanaka, Kenichi Yanagimoto, Tetsumei Urano, Naoki Unno, Tatsuya Moriyama
Abdominal aortic aneurysm (AAA) is a vascular disease involving gradual dilation of the abdominal aorta and high rupture-related mortality rates. AAA is histologically characterized by oxidative stress, chronic inflammation, and extracellular matrix degradation in the vascular wall. We previously demonstrated that aortic hypoperfusion could cause the vascular inflammation and AAA formation. However, the preventive method for hypoperfusion-induced AAA remains unknown. In this study, we evaluated the effect of fish oil on AAA development using a hypoperfusion-induced AAA animal model...
June 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/26993251/paraoxonase-1-overexpression-prevents-experimental-abdominal-aortic-aneurysm-progression
#18
Elena Burillo, Carlos Tarin, Monica-Maria Torres-Fonseca, Carlos-Ernesto Fernandez-García, Roxana Martinez-Pinna, Diego Martinez-Lopez, Patricia Llamas-Granda, Emilio Camafeita, Juan Antonio Lopez, Melina Vega de Ceniga, Michael Aviram, Jesus Egido, Luis-Miguel Blanco-Colio, Jose-Luis Martín-Ventura
Abdominal aortic aneurysm (AAA) is a permanent dilation of the aorta due to excessive proteolytic, oxidative and inflammatory injury of the aortic wall. We aimed to identify novel mediators involved in AAA pathophysiology, which could lead to novel therapeutic approaches. For that purpose, plasma from four AAA patients and four controls were analysed by a label-free proteomic approach. Among identified proteins, paraoxonase-1 (PON1) was decreased in plasma of AAA patients compared with controls, which was further validated in a bigger cohort of samples by ELISA...
June 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/26826714/preoperative-planning-of-left-sided-valve-surgery-with-3d-computed-tomography-reconstruction-models-sternotomy-or-a-minimally-invasive-approach
#19
Samuel Heuts, Jos G Maessen, Peyman Sardari Nia
OBJECTIVES: With the emergence of a new concept aimed at individualization of patient care, the focus will shift from whether a minimally invasive procedure is better than conventional treatment, to the question of which patients will benefit most from which technique? The superiority of minimally invasive valve surgery (MIVS) has not yet been proved. We believe that through better patient selection advantages of this technique can become more pronounced. In our current study, we evaluate the feasibility of 3D computed tomography (CT) imaging reconstruction in the preoperative planning of patients referred for MIVS...
May 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/26822581/the-progression-of-aortic-aneurysms
#20
REVIEW
Tara M Mastracci
Aortic aneurysm is a progressive disease that can involve any territory of the aorta. This has ramifications on endovascular repair, because progressive dilation of sealing zones can compromise the integrity of the repair and lead to long term failure. This article describes the evidence behind and some of the predictors of progressive disease of the aorta. Knowledge of predictors of progressive disease may help prevent it from causing failure in the longterm by helping to tailor surveillance routines or have influence on initial graft design...
April 2016: Journal of Cardiovascular Surgery
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