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https://www.readbyqxmd.com/read/28938749/the-testicular-transcriptome-associated-with-spermatogonia-differentiation-initiated-by-gonadotrophin-stimulation-in-the-juvenile-rhesus-monkey-macaca-mulatta
#1
Suresh Ramaswamy, William H Walker, Paula Aliberti, Rahil Sethi, Gary R Marshall, Alyxzandria Smith, Seyedmehdi Nourashrafeddin, Alicia Belgorosky, Uma R Chandran, Mark P Hedger, Tony M Plant
STUDY QUESTION: What is the genetic landscape within the testis of the juvenile rhesus monkey (Macaca mulatta) that underlies the decision of undifferentiated spermatogonia to commit to a pathway of differentiation when puberty is induced prematurely by exogenous LH and FSH stimulation? SUMMARY ANSWER: Forty-eight hours of gonadotrophin stimulation of the juvenile monkey testis resulted in the appearance of differentiating B spermatogonia and the emergence of 1362 up-regulated and 225 down-regulated testicular mRNAs encoding a complex network of proteins ranging from enzymes regulating Leydig cell steroidogenesis to membrane receptors, and from juxtacrine and paracrine factors to transcriptional factors governing spermatogonial stem cell fate...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938535/accurate-primary-germ-cell-cancer-diagnosis-using-serum-based-microrna-detection-amptsmir-test
#2
Ton van Agthoven, Leendert H J Looijenga
Multiple studies, including various methods and overall limited numbers of mostly heterogeneous cases, indicate that the level of embryonic stem cell microRNAs (miRs) (e.g. 371a-3p, 372-3p, 373-3p, and 367-3p) are increased in serum at primary diagnosis of almost all testicular germ cell cancer (TGCC). Here we determine the status of three of these miRs in serum samples of 250 TGCC patients, collected at time of primary diagnosis, compared with 60 non-TGCC patients and 104 male healthy donors. The levels of miRs were measured by the robust ampTSmiR test, including magnetic bead-based miR isolation and target specific pre-amplification followed by real-time quantitative PCR (RT-qPCR) detection...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938525/toxic-effects-of-tripterygium-wilfordii-hook-f-on-the-reproductive-system-of-adolescent-male-rats
#3
Xiaoping Jing, Weiwei Cheng, Sheng Guo, Ya Zou, Ting Zhang, Li He
Tripterygium wilfordii Hook F. (TWHF) is a compound extracted from Lei Gong Teng (Thunder God Vine) that has been used to treat a variety of immune-related diseases in clinical practice, particularly in pediatrics. Nevertheless, clinical data indicated that glycosides from Tripterygium wilfordii Hook F (GTW) are toxic to the male reproductive system, but the mechanism is unknown. Here, the administration of a high dose of GTW for 4 weeks and a low dose for 12 weeks can reduce the body weights and testes weights in adolescent male rats...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28938519/gilaburu-viburnum-opulus-l-fruit-extract-alleviates-testis-and-sperm-damages-induced-by-taxane-based-chemotherapeutics
#4
Serpil Sarıözkan, Gaffari Türk, Ayşe Eken, Latife Çakır Bayram, Ayşe Baldemir, Gülden Doğan
In this study, it was aimed to investigate the possible protective effects of gilaburu (Viburnum opulus L., Glb) fruit extract on testis and sperm damages induced by docetaxel (DTX) and paclitaxel (PTX) chemotherapeutics in rats. Sixty adult male Wistar albino rats were divided into 6 equal groups, 10 animals each. The groups were created as control (weekly i.p. saline injection), Glb (weekly i.p. saline injection and daily oral 100mg/kg Glb), DTX (weekly i.p. injection of 5mg/kg DTX), PTX (weekly i.p. injection of 4mg/kg PTX), DTX+Glb (weekly i...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28938492/a-long-noncoding-rna-lncrna-amhr2-plays-a-role-in-amhr2-gene-activation-in-mouse-ovarian-granulosa-cells
#5
Atsushi P Kimura, Ryoma Yoneda, Misuzu Kurihara, Shota Mayama, Shin Matsubara
Anti-Müllerian hormone (AMH) is critical to the regression of Müllerian ducts during mammalian male differentiation and targets ovarian granulosa cells and testicular Sertoli and Leydig cells of adults. Specific effects of AMH are exerted via its receptor, AMH type II receptor (Amhr2), but the mechanism by which the Amhr2 gene is specifically activated is not fully understood. To see whether a proximal promoter was sufficient to Amhr2 gene activation, we generated transgenic mice that bore the enhanced green fluorescent protein (EGFP) gene driven by a 500-bp mouse Amhr2 gene promoter...
September 14, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938237/fertility-restoration-with-spermatogonial-stem-cells
#6
Francesca de Michele, Maxime Vermeulen, Christine Wyns
PURPOSE OF REVIEW: This review evaluates the state of the art in terms of challenges and strategies used to restore fertility with spermatogonial stem cells retrieved from prepubertal boys affected by cancer. Although these boys do not yet produce spermatozoa, the only option to preserve their fertility is cryopreservation of spermatogonial stem cells in the form of testicular cell suspensions or whole tissue pieces. Different techniques have been described to achieve completion of spermatogenesis from human, spermatogonial stem cells but none is yet ready for clinical application...
September 21, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28937386/bilateral-seminomas-coexisting-with-adenomatoid-tumor-an-unusual-occurrence
#7
Suchi Mittal, Rathindra Sarangi, Sunila Jain
Coexistence of bilateral seminomas and adenomatoid tumor is rare. We encountered an interesting case of bilateral testicular seminomas along with a paratesticular nodule which was diagnosed as an adenomatoid tumor on histology. Although seminomas and adenomatoid tumor are frequent neoplasms, bilaterality and their coexistence have been rarely described and can pose diagnostic difficulties. Herein, we describe a case of a 53-year-old man who presented with bilateral testicular swellings which were diagnosed as bilateral seminomas with an adenomatoid tumor in the left paratesticular region on histopathology...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28935185/impact-of-hospital-case-volume-on-testicular-cancer-outcomes-and-practice-patterns
#8
Solomon L Woldu, Justin T Matulay, Timothy N Clinton, Nirmish Singla, Laura-Maria Krabbe, Ryan C Hutchinson, Arthur Sagalowsky, Yair Lotan, Vitaly Margulis, Aditya Bagrodia
BACKGROUND: Given the rarity of testicular germ cell tumors (TGCTs) and the complex aspects of management, we evaluate the effect of hospital TGCT case volume on overall survival outcomes and practice patterns. MATERIALS AND METHODS: The National Cancer Database was queried for patients diagnosed with seminoma or nonseminomatous germ cell tumor (NSGCT). Hospitals were classified by case volume as high (99th percentile, ≥26.1 cases annually), high-intermediate (95-99th percentile, 14...
September 18, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28934084/outcome-of-icsi-with-motile-testicular-spermatozoa-obtained-through-microscopically-assisted-testicular-sperm-extraction-in-relation-to-the-ovarian-response
#9
E Erdem, M Karacan, A Usta, A Arvas, Z Cebi, T Camlibel
INTRODUCTION: To determine the relationship between AFC, basal FSH level, woman's age, the number of oocytes retrieved and the outcome of ICSI with testicular spermatozoa obtained with microscopically assisted testicular sperm extraction. MATERIAL AND METHODS: In this retrospective cohort study, a total of 340 couples who underwent ICSI treatment with testicular sperm were enrolled. Women aged?40years and the first cycles of couples were included. ICSI was performed with motile testicular spermatozoa obtained from 89 men with obstructive azoospermia and 251 men with nonobstructive azoospermia...
May 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28932692/patient-with-antiphospholipid-syndrome-presenting-with-testicular-torsion-like-symptoms
#10
Arnav Srivastava, Joan Ko, Joy Ogunsile, Alison Moliterno, William H Westra, Alice Semerjian
Testicular torsion, a urological emergency, occurs due to absence of testicular blood supply secondary to a mechanical twist of the spermatic cord. The authors describe a 28-year-old male who presented with torsion symptoms, first in the left testicle and four months later in the right testicle. Doppler ultrasound and surgical exploration revealed disruption of blood flow but no evidence of spermatic cord twisting. Additionally, physical examination findings at the time of presentation were inconsistent with testicular torsion...
November 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28932616/the-monitoring-of-preoperative-external-detorsion-with-diffusion-weighted-imaging-in-a-patient-with-acute-testicular-torsion
#11
Mehmet Beyazal, Fatma Beyazal Çeliker, Mehmet Fatih İnecikli, Maksude Esra Kadioğlu, Hasan Rıza Aydın, Tuğba Durakoğlugil
Testicular torsion is one of the main causes of acute scrotum and may result in permanent damage of the testicular tissue. Color Doppler imaging has been frequently used in the diagnosis of testicular torsion and posttreatment follow-up period of the disease. There are some studies reporting the value and usefulness of diffusion-weighted imaging in the diagnosis of testicular torsion. However, to the best of our knowledge, there is no report regarding the monitoring of preoperative external detorsion in testicular torsion with diffusion-weighted imaging examination...
2017: Case Reports in Radiology
https://www.readbyqxmd.com/read/28929714/-extending-traceability-of-malignant-testicular-tumours-using-hospital-discharge-records-an-experience-in-veneto-region-northern-italy
#12
Mario Saugo, Giuseppe Mastrangelo, Gianstefano Blengio, Gianferruccio Righetto
OBJECTIVES: validation of codes of hospital discharge records (SDO) for identification of new cases of malignant testicular tumour in the Veneto Region (Northern Italy). DESIGN: record linkage between the regional archive of SDO and the archive of the Veneto Tumour Registry (VTR). SETTING AND PARTICIPANTS: extraction of cases from SDO source with ICD-9-CM 186 code for diagnosis and 62.3-62.4 codes for surgical procedure, and from VTR database using ICD-O-3 C62 code for site and 9060-9062, 9064-9066, 9070, 9071, 9080-9083, 9085, 9100, 9101 codes for morphology, with 5th digit behaviour code equal to "/3"...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28928476/bisphenol-a-affects-on-the-functional-properties-and-proteome-of-testicular-germ-cells-and-spermatogonial-stem-cells-in-vitro-culture-model
#13
Polash Chandra Karmakar, Hyun-Gu Kang, Yong-Hee Kim, Sang-Eun Jung, Md Saidur Rahman, Hee-Seok Lee, Young-Hyun Kim, Myung-Geol Pang, Buom-Yong Ryu
The endocrine disruptor bisphenol A (BPA) is well known for its adverse effect on male fertility. Growing evidence suggests that BPA may interact with testicular germ cells and cause infertility as a result of its estrogenic activity. Objective of current in vitro study was to investigate the proliferation, survivability and stemness properties of mouse testicular germ cells exposed to BPA, and to evaluate possible expression of cellular proteome. Our results showed that germ cell viability and proliferation were not affected by low concentrations (0...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927274/fluoride-induced-autophagy-via-the-regulation-of-mtor-phosphorylation-in-mice-leydig-cells
#14
Jianhai Zhang, Yuchen Zhu, Yan Shi, Yongli Han, Chen Liang, Zhiyuan Feng, Heping Zheng, Michelle Eng, Jundong Wang
Abstracts:Fluoride is known to impair testicular functions and decrease testosterone levels, yet the underlying mechanisms remain inconclusive. The objective of this study is to investigate the roles of autophagy in fluoride-induced male reproductive toxicity by both in vivo and in vitro Leydig cell models. Using Transmission Electron Microscopy (TEM) and Monodansylcadaverine (MDC) staining, we observed increasing numbers of autophagosomes in testicular tissue, especially in Leydig cells of fluoride-exposed mice...
September 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28926831/multiparameter-investigation-of-a-46-xx-46-xy-tetragametic-chimeric-phenotypical-male-patient-with-bilateral-scrotal-ovotestes-and-ovulatory-activity
#15
Yolande van Bever, Katja P Wolffenbuttel, Hennie T Brüggenwirth, Eric Blom, Annelies de Klein, Bert H J Eussen, Florijn van der Windt, Sabine E Hannema, Arianne B Dessens, Lambert C J Dorssers, Katharina Biermann, Remko Hersmus, Yolanda B de Rijke, Leendert H J Looijenga
We report on an adult male initially presenting with gynecomastia and a painless scrotal mass without additional genital anomalies. Hyperpigmentation of the skin following the Blaschko's lines was identified. He underwent gonadectomy because of suspected cancer. Histological analyses revealed an ovotestis with ovulatory activity confirmed by immunohistochemistry with multiple markers. Karyotyping of cultured peripheral blood lymphocytes and a buccal smear revealed a 46,XX/46,XY chimeric constitution with different percentages...
September 20, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28926535/testicular-macrophage-origin
#16
Zoltan Fehervari
No abstract text is available yet for this article.
September 19, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28926509/testicular-torsion-pain-honeymoons
#17
Larry Bruce Mellick, James Sinex
A subset of testicular torsion patients report resolution of their initial severe pain that is followed by variable periods of hours to days of reduced or absent pain. Other patients report only mild pain that is described as gradual in onset. Because of delayed initial presentations or less than timely returns for secondary evaluation, these pain honeymoons may be partially responsible for poor clinical outcomes of the torsed spermatic cords and ischemic testicles.
September 18, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28923598/testicular-atrophy-and-reproductive-quiescence-in-photorefractory-and-scotosensitive-quail-involvement-of-hypothalamic-deep-brain-photoreceptors-and-gnrh-gnih-system
#18
Somanshu Banerjee, Chandra Mohini Chaturvedi
Birds time their daily and seasonal activities in synchronization with circadian and annual periodicities in the environment, which is mainly provided by changes in photoperiod/day length conditions. Photoperiod appears to act at the level of eye, pineal and encephalic/deep brain photoperception and thus entrain the hypothalamic clock as well as reproductive circuitry in different avian species. In this article our focus of study is to elucidate out the underlying molecular mechanism of modulation of the hypothalamic reproductive circuitry following the photoperception through the hypothalamic photoreceptor cells and the subsequent alteration in the reproductive responses in quail, kept under different simulated photoperiodic conditions...
September 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28923067/a-new-insight-into-male-fertility-preservation-for-patients-with-completely-immotile-spermatozoa
#19
Huanhua Chen, Guixue Feng, Bo Zhang, Hong Zhou, Caizhu Wang, Jinhui Shu, Xianyou Gan, Ruoyun Lin, Dongmei Huang, Yingqin Huang
BACKGROUND: Sperm cryopreservation is the most effective method to preserve male fertility but this is normally used for motile spermatozoa. Thus, only motile spermatozoa are used for cryopreservation in most reproductive medicine centers worldwide. The immotile spermatozoa from some problematic patients are usually discarded, resulting in a missed opportunity of sterility cryopreservation for future assisted reproductive treatments. Many studies have shown that successful fertilization can be obtained after selection of viable sperm from the completely immotile spermatozoa before ICSI...
September 18, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28922723/protective-effects-of-mirtazapine-and-chrysin-on-experimentally-induced-testicular-damage-in-rats
#20
Alaa E El-Sisi, Magda E El-Sayad, Nermine M Abdelsalam
Mirtazapine is an antidepressant with prominent antioxidant effects. Chrysin, a natural flavone, exhibits multiple pharmacological actions. This study was designed to investigate the potential protective effects of chrysin and mirtazapine against nitrofurazone-induced testicular damage in rats. Possible underlying mechanisms such as oxidative stress, inflammation and apoptosis were also investigated. Testicular damage was induced by oral administration of nitrofurazone (50mg/kg/day) for two weeks. Chrysin (25 and 50mg/kg/day, p...
September 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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