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https://www.readbyqxmd.com/read/29166371/effect-of-iron-overload-on-impaired-fertility-in-male-patients-with-transfusion-dependent-beta-thalassemia
#1
Mei-Jou Chen, StevenShinn-Forng Peng, Meng-Yao Lu, Yung-Li Yang, Shiann-Tarng Jou, Hsiu-Hao Chang, Shee-Uan Chen, Dong-Tsamn Lin, Kai-Hsin Lin
BACKGROUND: To investigate the fertility of male patients with transfusion-dependent beta-thalassemia, and use MRI as a novel method to assess the iron overload status of testis in such patients. METHODS: Twenty-one male patients with transfusion-dependent beta-thalassemia and 5 normal male controls enrolled in this study. Hormonal profiles, iron levels, MRI testicular dimension, MRI T2 values, parameters for sperm quality, sperm DNA fragmentation (SDF) of participants were measured...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29166332/testicular-estrogen-secreting-leydig-cell-tumor-in-18f-fdg-pet-ct-an-incidental-detection-in-a-patient-treated-by-chemotherapy-for-hodgkin-lymphoma
#2
Axel Van Der Gucht, Zaher Maged, Rodolfo Burruni, Jean-Luc Barras, Niklaus Schaefer
We present images of a 50-year-old man who referred for treatment of a classic Hodgkin lymphoma. While F-FDG PET/CT demonstrated a complete metabolic remission after chemotherapy, an increased F-FDG uptake of a right testicular lesion in F-FDG PET/CT and an unexplained bilateral gynecomastia were observed. A benign Leydig cell tumor was histopathologically proved after a right radical orchiectomy. The serum estradiol level was abnormally elevated reflecting the estrogen-secreting profile. This report highlights that a focal F-FDG uptake in the testicular region with unexplained gynecomastia should suggest the diagnosis of an estrogen-secreting Leydig cell tumor on F-FDG PET/CT...
November 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29166288/spirulina-platensis-affects-factors-involved-in-spermatogenesis-and-increases-ghrelin-receptors-in-testis-tissue-of-rats-fed-a-high-fat-diet
#3
O B B Esener, E Gurel-Gurevin, B Isbilen-Basok, F Yigit, T Bilal, A Altiner, N Yilmazer, E I Armutak
Ghrelin is a peptide hormone which plays important role in maintaining growth hormone release and energy homeostasis in vertebrates. Spirulina platensis (SP) has antioxidant and hypolipidemic effects due to its ingredients. In this study we aimed to investigate the effects of SP on the testicular structure and relation between ghrelin and testosterone in the testis of rats fed a high fat diet (HFD). Sixty four young adult male rats were used and divided to 8 equal groups. Experimental groups received addition of 10% cholesterol (CHL), 43% hydrogenated vegetable oil (HVO) and 3% SP alone or in combination to basal diet while the control group received only basal diet...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29166263/effects-of-melatonin-implantation-on-the-fertility-potentials-of-kivircik-and-charollais-ewes-and-rams-during-the-non-breeding-season
#4
M Cevik, C Yilmazer, A Kocyigit
This study examined the effect of melatonin implantation during the non-breeding season on the reproductive performance of ewes and the testicular dimensions of rams. In seasonally anestrus Kivircik and Charollais ewes and rams were subjected to melatonin. Estrus response was significantly higher in treated than control ewes of both breeds (p<0.001). The pregnancy rate was significantly lower (p<0.001) in the control than in the treated animals. The twinning rate was significantly lower in melatonin implanted Kivircik than Charollais ewes (p<0...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29165614/long-term-health-in-recipients-of-transplanted-in-vitro-propagated-spermatogonial-stem-cells
#5
Callista L Mulder, Lisa A E Catsburg, Yi Zheng, Cindy M de Winter-Korver, Saskia K M van Daalen, Madelon van Wely, Steven Pals, Sjoerd Repping, Ans M M van Pelt
STUDY QUESTION: Is testicular transplantation of in vitro propagated spermatogonial stem cells associated with increased cancer incidence and decreased survival rates in recipient mice? SUMMARY ANSWER: Cancer incidence was not increased and long-term survival rate was not altered after transplantation of in vitro propagated murine spermatogonial stem cells (SSCs) in busulfan-treated recipients as compared to non-transplanted busulfan-treated controls. WHAT IS KNOWN ALREADY: Spermatogonial stem cell autotransplantation (SSCT) is a promising experimental reproductive technique currently under development to restore fertility in male childhood cancer survivors...
November 18, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29165613/exposure-to-concentrated-ambient-pm2-5-compromises-spermatogenesis-in-a-mouse-model-role-of-suppression-of-hypothalamus-pituitary-gonads-axis
#6
Lianglin Qiu, Minjie Chen, Xiaoke Wang, Xiaobo Qin, Sufang Chen, Yingyun Qian, Zhenzhen Liu, Qi Cao, Zhekang Ying
Background: Epidemiological studies link ambient fine particulate matter (PM2.5) pollution to abnormalities in the male reproductive system. However, few toxicological studies have investigated this potentially important adverse effect of PM2.5 pollution. Therefore, in the present study, we analyzed the effects of PM2.5 exposure on spermatogenesis and hypothalamic-pituitary- gonadal (HPG) axis in a murine model. Methods: Fourteen male C57BL/6J mice were subjected to a 4-month exposure to filtered air (FA) or concentrated ambient PM2...
November 20, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29164757/considerations-in-fertility-preservation-in-cases-of-genital-trauma
#7
B Z Starmer, A Baird, M A Lucky
OBJECTIVE: To perform a review of the literature to assess the options of preserving fertility in patients with fertility threatening testicular injuries and their efficacy to help guide surgeons who encounter these patients in the future. METHODS: Medline, EMBASE and Cochrane library databases were searched using the keywords treatment, therapy, management, scrotal trauma / injury, testicular trauma / injury / amputation, fertility and fertility preservation Inclusion criteria: studies reporting the fertility preserving techniques with a history of testicular trauma with loss of one, both or nearly all testicular parenchymal tissue RESULTS: Two cases of testicular sperm extraction, eight cases of testicular replantation, and one case of cryopreservation after injury were identified...
November 22, 2017: BJU International
https://www.readbyqxmd.com/read/29164711/vitamin-e-improves-testicular-damage-in-streptozocin-induced-diabetic-rats-via-increasing-vascular-endothelial-growth-factor-and-poly-adp-ribose-polymerase-1
#8
S S Omar, R G Aly, N M Badae
The precise mechanism by which diabetes impairs spermatogenesis and testicular function is not exactly known. Vascular endothelial growth factor (VEGF) and poly(ADP-ribose) polymerase-1 (PARP-1) are important for germ cell homeostasis and repair of DNA respectively. The aim of this study was to investigate the correlation between diabetes-induced testicular damage and testicular VEGF and PARP-1 expression and the possible protective role of vitamin E supplementation. A total of 45 male Wistar albino rats were randomly divided into three groups: Group I (nondiabetic rats), Group II (streptozocin-induced diabetic rats) and Group III (streptozocin-induced diabetic rats treated orally with 0...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29164652/cerium-oxide-nanoparticle-elicits-oxidative-stress-endocrine-imbalance-and-lowers-sperm-characteristics-in-testes-of-balb-c-mice
#9
O A Adebayo, O Akinloye, O A Adaramoye
The toxicity of metallic nanoparticles is a growing concern due to its application in industries and homes. We investigated the toxicity of cerium oxide nanoparticles (CeO2 NPs) on reproductive system in male balb/c mice. Twenty mice were divided into four groups of five animals each and treated thus: normal saline (control), 100, 200 and 300 μg/kg CeO2 NPs (i.p.,) thrice in a week for five consecutive weeks. Results showed that CeO2 NPs significantly reduced the levels of haemoglobin, PCV and RBC count relative to controls...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29163975/on-the-descent-of-the-epididymo-testicular-unit-cryptorchidism-and-prevention-of-infertility
#10
REVIEW
Faruk Hadziselimovic
This comprehensive review provides in-depth coverage of progress made in understanding the molecular mechanisms underlying cryptorchidism, a frequent pathology first described in about 1786 by John Hunter. The first part focuses on the physiology, embryology, and histology of epididymo-testicular descent. In the last 20 years epididymo-testicular descent has become the victim of schematic drawings with an unjustified rejection of valid histological data. This part also includes discussion on the roles of gonadotropin-releasing hormone, fibroblast growth factors, Müllerian inhibiting substance, androgens, inhibin B, and insulin-like 3 in epididymo-testicular descent...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29163367/a-testis-specific-long-non-coding-rna-lncrna-tcam1-regulates-immune-related-genes-in-mouse-male-germ-cells
#11
Misuzu Kurihara, Kai Otsuka, Shin Matsubara, Akira Shiraishi, Honoo Satake, Atsushi P Kimura
Spermatogenesis is precisely controlled by hormones from the hypothalamus-pituitary-gonadal axis and testis-specific genes, but the regulatory mechanism is not fully understood. Recently, a large number of long non-coding RNAs (lncRNAs) are found to be transcribed at each stage of meiosis of male germ cells, and their functions in spermatogenesis have yet to be fully investigated. lncRNA-testicular cell adhesion molecule 1 (lncRNA-Tcam1) is a nuclear lncRNA which is specifically expressed in mouse male germ cells and presumed to play a role in gene regulation during meiosis...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29162477/mir-301b-3p-3584-5p-enhances-low-dose-mono-n-butyl-phthalate-mbp-induced-proliferation-by-targeting-rasd1-in-sertoli-cells
#12
Xiaoqin Yin, Tan Ma, Ruitong Han, Jie Ding, Huan Zhang, Xiaodong Han, Dongmei Li
To investigate the possible molecular mechanism of low concentration plasticizer mono-n-butyl phthalate (MBP) -induced juvenile Sertoli cells (SCs) proliferation, we evaluated global alterations of miRNA and mRNA expression in rat SCs treated with 0.1mM MBP. Microarray analysis revealed that miR-3584-5p and miR-301b-3p were up-regulated and their common target gene Dexamethasone-induced Ras-related protein 1 (Rasd1) was down-regulated. Further work suggested that SCs proliferation induced by low concentration MBP in vitro might be mediated by Rasd1 regulating ERK1/2 signaling pathway...
November 18, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29161714/a-rare-cause-of-male-infertility-45-x-46-xy-mosaicism
#13
Emre Can Akinsal, Numan Baydilli, Ruslan Bayramov, Oguz Ekmekcioglu
OBJECTIVE: To present the clinical, chromosomal, and endocrinological features of 8 infertile male cases with the 45,X/46,XY karyotype who were admitted to our infertility clinic. MATERIALS AND METHODS: The records of cases who were admitted to our infertility clinic between 1999 and 2015 were investigated. Eight cases with 45,X/46,XY were detected. The clinical, endocrinological, and chromosomal assessments were analyzed. Each patient's height, weight, body mass index, testicular volume, endocrine hormone levels, follow-up period semen analysis, testicular biopsy reports, and karyotype analysis were evaluated retrospectively...
November 21, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29161153/protective-effects-of-agomelatine-on-testicular-damage-caused-by-bortezomib
#14
N Akaras, T Bal, H Atilay, J Selli, M B Halici
Bortezomib is a chemotherapeutic agent used to treat several cancers; however, it exhibits severe side effects in testicular tissue. We investigated the use of agomelatine to prevent testicular tissue damage caused by bortezomib. We used 36 male Sprague-Dawley rats divided randomly into six equal groups: group 1, no treatment control; group 2, agomelatine treatment only; group 3, bortezomib treatment only for 48 h; group 4, bortezomib + agomelatine treatment for 48 h; group 5, bortezomib treatment only for 72 h; and group 6, bortezomib + agomelatine treatment for 72 h...
November 21, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29160922/igf1r-signalling-in-testicular-germ-cell-tumour-cells-impacts-on-cell-survival-and-acquired-cisplatin-resistance
#15
Joanna Selfe, Neil C Goddard, Alan McIntyre, Kathryn R Taylor, Jane Renshaw, Sergey D Popov, Khin Thway, Brenda Summersgill, Robert A Huddart, Duncan C Gilbert, Janet M Shipley
Testicular germ cell tumours (TGCT) are the most frequent malignancy and cause of death from solid tumours in the 20-40 year age group. Although most cases show sensitivity to cis-platinum-based chemotherapy, this is associated with long-term toxicities and chemo-resistance. Roles for receptor tyrosine kinases other than KIT are largely unknown in TGCT. We therefore conducted a phosphoproteomic screen and identified the insulin growth factor receptor-1 (IGF1R) as both highly expressed and activated in TGCT cell lines representing the non-seminomatous subtype...
November 21, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29159543/endosulfan-is-toxic-to-the-reproductive-health-of-male-freshwater-fish-cyprinion-watsoni
#16
Fakhar Ul Islam, Samina Jalali, Mustafa Nawaz Shafqat, Syed Tahir Abbas Shah
Endosulfan is an organochlorine pesticide that is toxic to aquatic life. Endosulfan might hamper the reproductive health of indigenous fish in agricultural areas of Pakistan where this pesticide is sprayed widely. The aim of the current study is to investigate the toxic effects of endosulfan on selected reproductive parameters of male freshwater fish, Cyprinion watsoni. Two concentrations of endosulfan (0.5 and 1 ppb for 30 days exposure) were tested for their effects on body weight, body length, and testicular weight, length, and width...
November 20, 2017: Die Naturwissenschaften
https://www.readbyqxmd.com/read/29158902/hypernatraemic-hypovolaemia-with-anaemia-an-unusual-presentation-of-primary-testicular-insufficiency
#17
Usman Javaid, Vikram Lal, Catherine Napier, Alison Burbridge, Richard Quinton
Hypogonadal men may experience intense vasomotor symptoms, and vasomotor sweating can occasionally be associated with profound fluid losses. We describe a 37-year-old male, who exhibited persistent hypovolaemic hypernatraemia that was challenging to treat despite a continuous high fluid input (>4-5 L/day). He was noted to have drenching sweats and normochromic anaemia. He had recent traumatic head injury, which resulted in neurocognitive dysfunction, so pituitary function tests were done which showed primary hypogonadism...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29157197/selection-for-female-traits-of-high-fertility-affects-male-reproductive-performance-and-alters-the-testicular-transcriptional-profile
#18
Marten Michaelis, Alexander Sobczak, Dirk Koczan, Martina Langhammer, Norbert Reinsch, Jennifer Schoen, Joachim M Weitzel
BACKGROUND: Many genes important for reproductive performance are shared by both sexes. However, fecundity indices are primarily based on female parameters such as litter size. We examined a fertility mouse line (FL2), which has a considerably increased number of offspring and a total litter weight of 180% compared to a randomly bred control line (Ctrl) after more than 170 generations of breeding. In the present study, we investigated whether there might be a parallel evolution in males after more than 40 years of breeding in this outbred mouse model...
November 21, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29156776/uchl1-expression-and-localization-on-testicular-development-and-spermatogenesis-of-chinese-giant-salamanders
#19
Yuanxian Wang, Liqing Wang, Huihui Gao, Yao Gao, Changming Yang, Hong Ji, Wuzi Dong
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1), which is extensively expressed in vertebrates, is a deubiquitinating enzymes that inhibits the degradation of proteins by reversing ubiquitination modification. Herein, a 1087-bp sequence encoding UCHL1 was identified from the Chinese giant salamander (CGS; Andrias davidianus). The coding sequences (CDS) of UCHL1 encoded a putative poly peptide of 222 amino acids. The CGS UCHL1 isoforms were more related to their human and mouse counterparts. The phylogenic tree of vertebrate UCHL1 indicated that CGS UCHL1 has the closest relationship with human UCHL1 (up to 73...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156766/isobaric-tags-for-relative-and-absolute-quantification-based-proteomic-analysis-of-testis-biopsies-in-rhesus-monkeys-treated-with-transient-scrotal-hyperthermia
#20
Meng Rao, Sha Ma, Shifu Hu, Hui Lei, Yanqing Wu, Yanfei Zhou, Wei Xia, Changhong Zhu
This study aimed to examine the cellular and molecular events that occur in rhesus monkey testes after scrotal hyperthermia. Eight male adult rhesus monkeys were subjected to scrotal hyperthermia at 43°C for 30 min daily for 6 consecutive days. Sperm concentration, reproductive hormones, and testis histology were examined before hyperthermia (day 0), and at 8, 15, 30, 45, 60, 75, and 90 days after the initiation of hyperthermia. iTRAQ-based proteomic analysis was conducted on testicular tissues collected on days 0, 8, and 60 to identify differentially expressed proteins at the early and recovery stages of testicular damage...
October 17, 2017: Oncotarget
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