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https://www.readbyqxmd.com/read/29792900/the-sulfoconjugation-of-androstenone-and-dehydroepiandrosterone-by-human-and-porcine-sulfotransferase-enzymes
#1
Heidi Laderoute, Christine Bone, E James Squires
Porcine sulfotransferase 2A1 (pSULT2A1) is a key enzyme involved in the testicular and hepatic sulfoconjugation of steroids such as dehydroepiandrosterone (DHEA) and potentially androstenone. This latter steroid is a major cause of boar taint, which is an unpleasant off-odour and off-flavour in pork from male pigs. Sulfotransferase 2B1 (pSULT2B1) may also be important, although no direct evidence exists for its involvement in sulfoconjugation of steroids. The purpose of this study was to investigate the sulfoconjugation activity of human and porcine sulfotransferases towards DHEA and androstenone...
May 21, 2018: Steroids
https://www.readbyqxmd.com/read/29792376/somatic-ace-regulates-self-renewal-of-mouse-spermatogonial-stem-cells-via-the-mapk-signaling-pathway
#2
Tingting Gao, Xin Zhao, Chenchen Liu, Binbin Shao, Xi Zhang, Kai Li, Jinyang Cai, Su Wang, Xiaoyan Huang
Spermatogonial stem cell (SSC) self-renewal is an indispensable part of spermatogenesis. Angiotensin I-converting enzyme (ACE) is a zinc dipeptidyl carboxypeptidase that plays a critical role in regulation of the renin-angiotensin system. Here, we used RT-PCR and Western blot analysis to confirm that somatic ACE (sACE) but not testicular ACE (tACE) is highly expressed in mouse testis before postpartum day 7 and in cultured SSCs. Our results revealed that sACE is located on the membrane of SSCs. Treating cultured SSCs with the ACE competitive inhibitor captopril was found to inhibit sACE activity, and significantly reduced the proliferation rate of SSCs...
May 24, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29792185/assessment-of-the-use-of-contrast-enhanced-ultrasound-in-guiding-microdissection-testicular-sperm-extraction-in-nonobstructive-azoospermia
#3
Shijun Zhang, Jing Du, Ruhui Tian, Shaowei Xie, Fenghua Li, Zheng Li
BACKGROUND: The aim of this study is to assess the value of contrast-enhanced ultrasound (CEUS) as a new non-invasive approach to locate the testicular area in which spermatogenesis is most likely to be found in non-obstructive azoospermic testes and to evaluate the accuracy of CEUS as a predictor of successful sperm retrieval. METHODS: CEUS was performed in 120 nonobstructive azoospermia (NOA) patients. Microdissection testicular sperm extraction (M-TESE) was performed on the best and poorest perfusion areas selected by CEUS and on conventional areas...
May 23, 2018: BMC Urology
https://www.readbyqxmd.com/read/29791833/maternal-and-postnatal-high-fat-diets-with-high-6-3-ratios-affect-the-reproductive-performance-of-male-offspring-in-the-mouse
#4
S Bianconi, G Stutz, M R Solís, A C Martini, L M Vincenti, M F Ponzio, E Luque, C Avendaño, P Quiroga, M E Santillán
High-fat diets (HFDs) are an acknowledged risk factor for male subfertility, but the underlying mechanisms remain unclear. In the present study we compared the effects of two HFDs with different ω6:ω3 ratios, one enriched with soy oil (SOD; ω6:ω3=9.62) and another enriched with sunflower oil (SFOD; ω6:ω3=51.55), with those of a commercial diet (CD; ω6:ω3=19.87), supplied from pregnancy to adulthood, on morphometric parameters and reproductive performance in adult male mice (recommended ω6:ω3 for rodents=1-6)...
May 24, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29791311/protective-effects-of-persian-honey-apis-mellifera-meda-skorikov-on-side-effects-of-chemotherapy-and-ischemia-reperfusion-induced-testicular-injury
#5
Mohammadreza Gholami, Abolfazl Abbaszadeh, Parastoo Baharvand, Afshin Hasanvand, Amin Hasanvand, Anneh Mohammad Gharravi
Introduction The aim of the present study was to survey the protective effect of pretreatment with Persian honey on amelioration of side effects of chemotherapy and ischemia/reperfusion induced testicular injury. Materials and methods Forty adult's male wistar rats were divided into four groups of ischemia-reperfusion (IR), honey + ischemia-reperfusion (HIR), Busulfan (B) and Busulfan intraperitoneally+ honey (BH). The seminiferous tubules were rated for their modified spermatogenesis index (SI) by Johnsons score...
May 23, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29790047/ascorbic-acid-inhibits-cadmium-induced-disruption-of-the-blood-testis-barrier-by-regulating-oxidative-stress-mediated-p38-mapk-pathways
#6
Na Chen, Ping Su, Mei Wang, Ya-Min Li
Ascorbic acid (AA), one of the best-known reactive oxygen species (ROS) scavengers, exhibits numerous functions such as antioxidant, anti-cancer, and anti-inflammatory effects. Increasing evidence demonstrates that oxidative stress plays an important role in testicular toxicity. In the present study, we investigated the protective effect of AA against cadmium (Cd)-induced blood-testis barrier (BTB) disruption. Sprague-Dawley (SD) rats were divided into four groups: the Cd-treated group received a single dose (s...
May 22, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29789566/transcriptome-analysis-of-the-adult-human-klinefelter-testis-and-cellularity-matched-controls-reveals-disturbed-differentiation-of-sertoli-and-leydig-cells
#7
Sofia Boeg Winge, Marlene Danner Dalgaard, Kirstine G Belling, Jacob Malte Jensen, John Erik Nielsen, Lise Aksglaede, Mikkel Heide Schierup, Søren Brunak, Niels Erik Skakkebæk, Anders Juul, Ewa Rajpert-De Meyts, Kristian Almstrup
The most common human sex chromosomal disorder is Klinefelter syndrome (KS; 47,XXY). Adult patients with KS display a diverse phenotype but are nearly always infertile, due to testicular degeneration at puberty. To identify mechanisms causing the selective destruction of the seminiferous epithelium, we performed RNA-sequencing of 24 fixed paraffin-embedded testicular tissue samples. Analysis of informative transcriptomes revealed 235 differentially expressed transcripts (DETs) in the adult KS testis showing enrichment of long non-coding RNAs, but surprisingly not of X-chromosomal transcripts...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29789155/endocrine-and-metabolic-profile-of-peripubertal-standardbred-colts
#8
Robyn E Ellerbrock, Igor F Canisso, Fabio S Lima, Clifford F Shipley, Donald L Thompson, Alan J Conley, Kevin H Kline
The objectives of this study were to determine the concentrations of reproductive and metabolic hormones during the peripubertal period and to assess their relationship with testicular development and body fat deposition. Blood samples were collected from 23 healthy Standardbred colts every four weeks for twelve months. Colts were weighed monthly, and percent of body fat and testicular volume estimated by ultrasound. Onset of puberty was determined as the month when testosterone was two standard deviations above the previous mean...
May 14, 2018: Theriogenology
https://www.readbyqxmd.com/read/29788785/impaired-serotonin-communication-during-juvenile-development-in-rats-diminishes-adult-sperm-quality
#9
Juan Díaz-Ramos, Maribel Flores-Flores, María E Ayala, Andrés Aragón-Martínez
Spermatogenesis and steroidogenesis are testicular functions regulated by gonadotrophins as well as other factors, including serotonin. Testicular serotonin acts as an autocrine regulator of testosterone secretion, but studies on its role in spermatogenesis and sperm quality are scarce. Here, we analyzed the effects of intratesticular inhibition of serotonin synthesis on gonadotrophins, testosterone, and sperm quality. Both testicles of 30-day-old rats were injected once with saline solution (SS) or distinct concentrations of p-chloroamphetamine (PCA) (0...
May 22, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29788434/a-novel-mouse-model-of-testicular-granulosa-cell-tumors
#10
Xin Fang, Nan Ni, Yang Gao, David F Vincent, Laurent Bartholin, Qinglei Li
STUDY QUESTION: What is the role of dysregulated transforming growth factor beta (TGFB) signaling in the development of sex cord-stromal tumors in the testis? SUMMARY ANSWER: Overactivation of TGFB signaling results in the development of testicular tumors resembling granulosa cell tumors (GrCTs). WHAT IS KNOWN ALREADY: In an earlier study, we demonstrated that constitutively active TGFB receptor 1 (TGFBR1) in ovarian somatic cells promotes the development of ovarian GrCTs...
May 21, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29788389/pregnancy-after-vasectomy-surgical-reversal-or-assisted-reproduction
#11
U Valerie, S De Brucker, M De Brucker, V Vloeberghs, P Drakopoulos, S Santos-Ribeiro, H Tournaye
STUDY QUESTION: Should we opt for surgical vasovasostomy or IVF/ICSI after a vasectomy? SUMMARY ANSWER: Both options reveal acceptable pregnancy rates though the time to pregnancy was significantly lower in the immediate IVF/ICSI group. WHAT IS KNOWN ALREADY: About 7.4% of men regret their vasectomy and express a renewed child wish. The choice between surgical vasectomy reversal or ICSI remains difficult for patients and their fertility specialist...
May 17, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29788325/ancestral-tcdd-exposure-induces-multigenerational-histologic-and-transcriptomic-alterations-in-gonads-of-male-zebrafish
#12
Danielle N Meyer, Bridget B Baker, Tracie R Baker
TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin), the classic AhR (aryl hydrocarbon receptor) agonist, is a potent environmental toxicant and endocrine-disrupting chemical (EDC) with known developmental toxicity in humans, rodents, and fish. Early life exposure to some EDCs, including TCDD, is linked to the occurrence of adult-onset and multigenerational disease. Previous work exposing juvenile F0 zebrafish (Danio rerio) to 50 ppt (parts per trillion) TCDD during reproductive development has shown male-mediated transgenerational decreases in fertility (F0-F2) and histological and transcriptomic alterations in F0 testes...
May 21, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29785651/genetic-analysis-of-the-human-insulin-like-3-gene-in-pediatric-patients-with-testicular-torsion
#13
Anna Paola Capra, Elisa Ferro, Maria Angela La Rosa, Silvana Briuglia, Tiziana Russo, Salvatore Arena, Carmelo Salpietro Damiano, Carmelo Romeo, Pietro Impellizzeri
PURPOSE: Testicular torsion (TT) mainly affects boys under 18 years old. To avoid orchiectomy, TT requires an immediate operative management. The etiology of TT is still controversial. Observed familiar recurrence suggests the presence of a genetic involvement. The INSL3 gene consists of two exons, and it is specifically expressed in fetal and adult Leydig cells. In transgenic mice, deletion of this gene was observed an increased testicular mobility and testicular torsion. We have hypothesized the possible involvement of the INSL3 gene as a predisposing factor of human TT...
May 21, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29785601/alteration-in-apoptotic-rate-of-testicular-cells-and-sperms-following-administration-of-bisphenol-a-bpa-in-wistar-albino-rats
#14
Seema Srivastava, Priya Gupta
The aim of the study was to evaluate the effect of Bisphenol A [BPA] widely used as a plasticizer in the formation of polycarbonate plastics and epoxy resins, exposure causing alteration in apoptosis rate, and protective effect of Vitamin E when supplemented with BPA orally. Adult male Wistar albino rats aged 3 months were randomly divided into seven groups: control (olive oil treated) BPA-treated (dose 5, 50,100 μg/100gmBW) and Vitamin E intervention group (dose 5, 50, 100 μg/100gmBW BPA+ Vitamin E dose 4 mg/100gmBW)...
May 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29785532/comparison-of-intracytoplasmic-sperm-injection-outcome-with-fresh-versus-frozen-thawed-testicular-sperm-in-men-with-nonobstructive-azoospermia-a-systematic-review-and-meta-analysis
#15
Zhe Yu, Zhewen Wei, Jun Yang, Tao Wang, Hongyang Jiang, Hao Li, Zhe Tang, Shaogang Wang, Jihong Liu
PURPOSE: The purpose of the study is to explore testicular sperm cryopreservation in patients with nonobstructive azoospermia (NOA) whether affect the outcome of subsequent intracytoplasmic sperm injection (ICSI). METHODS: A systematic review and meta-analysis was conducted by searching the MEDLINE and EMBASE databases for relevant published studies in English language (1997-2017). Studies were eligible if they included the comparison of using fresh and frozen-thawed testicular sperm followed by ICSI...
May 21, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29785530/azoospermia-and-embryo-morphokinetics-testicular-sperm-derived-embryos-exhibit-delays-in-early-cell-cycle-events-and-increased-arrest-prior-to-compaction
#16
Nina Desai, Pavinder Gill, Nicholas N Tadros, Jeffrey M Goldberg, Edmund Sabanegh, Tommaso Falcone
PURPOSE: Sperm play an essential role in embryonic genome activation and embryonic progression to blastocyst. In the present work, we focus on development of embryos created as a result of ICSI with testicular or epididymal sperm from azoospermic males and compare this to outcomes from normospermic males. The objective of this study was to determine if sperm origin influences clinical outcomes, the kinetics of embryo development, or the incidence of cleavage anomalies and multinucleation...
May 21, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29785490/microcirculatory-effects-of-sildenafil-in-experimental-testicular-torsion-in-rats
#17
Márton Oroszi, Andrea Szabó, Ádám Miklós Fehér, Gábor Deák, Zoltán Bajory
PURPOSE: Investigate the short-term effect of sildenafil on microcirculation, especially the velocity, the pattern of the flow and the recruitment of the leukocyte in postcapillaries. METHODS: In male Sprague-Dawley rats, the microcirculatory consequences of 60 min experimental testicular torsion, followed by 240 min of reperfusion, were examined. Using fluorescence intravital microscopy, changes in red blood cell velocity in post-capillary venules and rolling as well as adhesion of leukocytes in the postcapillary venules were examined before the torsion and every hour during the reperfusion period...
May 21, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29784463/anti-m%C3%A3-llerian-hormone-profiling-in-prepubertal-horses-and-its-relationship-with-gonadal-function
#18
Dragos Scarlet, Manuela Wulf, Juliane Kuhl, Martin Köhne, Natascha Ille, Alan J Conley, Christine Aurich
Anti-Müllerian hormone (AMH) has gained increasing interest as a biomarker for assessment of gonadal activity. The ability to predict the ovarian follicular reserve of prepubertal female horses (fillies) or to identify stallions with testicular pathologies already during their prepubertal life has not been analyzed so far. Both would help to select fertile horses and reduce costs associated with keeping animals. The objectives of the present study were to (1) assess AMH, LH, FSH, progesterone (females) and testosterone (males) dynamics in prepubertal horses from birth onwards and (2) determine whether AMH concentrations detected in plasma of prepubertal female and male horses are correlated with postpubertal gonadal development...
May 15, 2018: Theriogenology
https://www.readbyqxmd.com/read/29783595/re-the-role-of-social-cognitive-and-emotional-factors-on-testicular-self-examination
#19
Jerome P Richie
No abstract text is available yet for this article.
June 2018: Journal of Urology
https://www.readbyqxmd.com/read/29783594/re-attitudes-toward-testicular-cancer-and-self-examination-among-northern-irish-males
#20
Jerome P Richie
No abstract text is available yet for this article.
June 2018: Journal of Urology
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