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Head and Neck AND cancer AND nutrition

Shih-Lun Lo, Yu-Hsiu Yen, Pi-Jung Lee, Charles Chih-Ho Liu, Chi-Ming Pu
PURPOSE: The present study aimed to analyze multiple variables and to determine the factors influencing postoperative complications in reconstructive microsurgeries for head and neck cancer. MATERIALS AND METHODS: This was a retrospective review of the medical records of patients with head and neck cancer who underwent free flap reconstruction after ablation surgery at the Cathay General Hospital (Taipei, Taiwan) from January 2010 to December 2014. Clinical and surgical procedure-related factors were retrieved from a database and analyzed...
September 23, 2016: Journal of Oral and Maxillofacial Surgery
Caroline Brammer, Sundus Yahya, Dawn Dawson, Carol Glaister, Susan B Merrick
OBJECTIVES: The aim of this feasibility study is to define the resource effectiveness of Cetuximab versus cisplatin given concomitantly with radiotherapy for squamous cell carcinoma within a NHS clinical oncology unit. METHODS: 20 Patients with stage 3 or 4 head and neck squamous cell cancers were randomised to receive either Cetuximab with radiotherapy (ERT) or cisplatin with radiotherapy (CRT) concurrent with external beam radiotherapy 70 Gy in 35 fractions on a 1:1 basis over a 12-month duration...
October 13, 2016: British Journal of Radiology
Takeshi Shinozaki, Mitsuru Ebihara, Satoru Iwase, Takuhiro Yamaguchi, Hitoshi Hirakawa, Wataru Shimbashi, Tomoyuki Kamijo, Makito Okamoto, Takeshi Beppu, Junichiro Ohori, Kazuto Matsuura, Motoyuki Suzuki, Hiroshi Nishino, Yuichiro Sato, Hiroto Ishiki
BACKGROUND: Little is known about quality of life and functional status of patients with terminally ill head and neck cancers. METHODS: We conducted a multicenter, prospective, observational study to examine quality of life and functional status in terminally ill head and neck cancer patients. RESULTS: Of the 100 patients meeting inclusion criteria, 72 were observed until death. There was no significant difference in the quality of life score between baseline and Week 3...
September 27, 2016: Japanese Journal of Clinical Oncology
Miho Ishimaru, Sachiko Ono, Sayaka Suzuki, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
BACKGROUND: The purpose of this study was to compare the effect of cetuximab-based radiotherapy (RT) with cisplatin-based concomitant chemoradiotherapy (CCRT) on artificial nutrition dependence in locoregional advanced head and neck cancer. METHODS: We identified patients treated with cetuximab-based RT or CCRT between 2012 and 2014 in a Japanese national database, and used propensity score-matched analyses to evaluate artificial nutrition dependence for 30 days after starting chemotherapy and at hospital discharge...
September 16, 2016: Head & Neck
Maria Gebre-Medhin, Mahnaz Haghanegi, Lotta Robért, Elisabeth Kjellén, Per Nilsson
INTRODUCTION: Trismus is a treatment-related late side effect in patients treated for cancer in the head and neck region (HNC). The condition can have a considerable negative impact on nutrition, dental hygiene, ability to speak and quality of life. We have previously studied trismus within the frame of a randomized phase 3 study of HNC patients treated with mainly three-dimensional (3D) conformal radiotherapy (CRT) and found a strong association to mean radiation dose to the mastication muscles, especially the ipsilateral masseter muscle (iMAS)...
November 2016: Acta Oncologica
Wen-Xing Kang, Wentao Li, Shi-Gao Huang, Yazhang Dang, Hongxiang Gao
Head and neck malignant tumors have numerous locations of the disease. After patients receive radiotherapy, their nutritional status is very poor, thus the curative effect is unsatisfactory. The aims of the present study were to investigate and analyze the nutritional status of patients with head and neck cancer undergoing radiotherapy (RT) in order to provide positive nutrition intervention for assisting the radiotherapy effect. A total of 40 patients with head and neck cancer were selected using a method of subjective global assessment (SGA) to assess nutritional status, including calorie intake and energy expenditure...
September 2016: Molecular and Clinical Oncology
Lise-Marie Roussel, Emmanuel Micault, Damien Peyronnet, David Blanchard, Séverine Guarnieri, Olivier Choussy, Bernard Géry, Arnaud Béquignon, Corinne Joubert, Jean-Jacques Parienti, Emmanuel Babin
Nutritional care improves quality of life (QOL) in head and neck cancer patients treated with radiotherapy. The aim of our study was to determine whether intensive nutritional care (INC) would further improve QOL. In addition to a control group based on European and American guidelines, patients included in the INC group received six meetings with a dietitian. QOL was measured after radiotherapy using the EORTC QLQ-C30. We performed a meta-analysis to determine the best nutritional care. In the 87 patients, the QOL scores, weight, energy, and protein intakes were similar between the INC group (n = 43) and the control group (n = 44)...
August 27, 2016: European Archives of Oto-rhino-laryngology
Natalie Pattison, Matthew Rd Brown, Anthony Gubbay, Janet Peacock, Joy R Ross, Suzanne Chapman, Odile Sauzet, John Williams
BACKGROUND: Treatment for head and neck cancer can frequently be a painful experience with implications for patients in terms of quality of life, nutrition and ultimately treatment outcomes. Pain may arise for a number of reasons in this patient group including the influence of localised tissue damage from radiotherapy, the effects of chemotherapeutic agents as well as the disease process itself. Early identification of cancer pain, through screening and early analgesic and pain management are thought to be the most appropriate approaches to the problem...
February 2016: British Journal of Pain
Moonkyoo Kong, Deok-Sang Hwang, Seong Woo Yoon, Jinsung Kim
PURPOSE: This study was performed to evaluate the efficacy and safety of clove-based herbal mouthwash in ameliorating radiation-induced oral mucositis in patients with head and neck cancer. METHODS: Fourteen patients were prospectively enrolled in this study and randomized to either an experimental group or a control group. The patients of the experimental group swished their mouths with a clove-based herbal mouthwash during radiotherapy (RT), while the patients of the control group swished with clear water...
2016: OncoTargets and Therapy
Sarah Bishop, Warren Michael Reed
Combination chemoradiation is the gold standard of management for locally advanced squamous cell carcinomas of the head and neck. One of the most significant advantages of this approach to treatment is organ preservation which may not be possible with radical surgery. Unfortunately, few treatments are without side-effects and the toxicity associated with combined modality treatment causes meaningful morbidity. Patients with head and neck cancer (HNC) may have difficulties meeting their nutritional requirements as a consequence of tumour location or size or because of the acute toxicity associated with treatment...
December 2015: Journal of Medical Radiation Sciences
Ayman Abu R, Tawfik Khoury, Jonah Cohen, Shmuel Chen, Shaul Yaari, Saleh Daher, Ariel A Benson, Meir Mizrahi
BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) tubes are commonly utilized as a method of enteral feeding in patients unable to obtain adequate oral nutrition. Although some studies have shown improved mortality in select populations, the safety and effectiveness of PEG insertion in patients with dementia compared with those with other neurological diseases or head and neck malignancy remains less well defined. OBJECTIVE: To evaluate the nutritional effectiveness, rate of rehospitalization, and risk of mortality among patients with dementia compared with patients with other neurological diseases or head and neck cancers who undergo PEG placement...
August 8, 2016: Journal of Clinical Gastroenterology
Sylvie Khan, Taher Arif Alibay, Mansouria Merad, Mario DiPalma, Bruno Raynard, Sami Antoun
Malnutrition is frequently observed in oncology. The consequences on patient survival, chemotherapy toxicities and quality of life need to be identified and treated appropriately. A set of tools are available that enable clinicians to diagnose and detect malnutrition. Each tool must consider three items: the patient's current nutritional status, reduced food intake and the characteristics of the underlying disease. The parameters and thresholds used to detect malnutrition differ according to the objective pursued...
September 2016: Bulletin du Cancer
Elske Sieswerda, Anna Font-Gonzalez, Johannes B Reitsma, Marcel G W Dijkgraaf, Richard C Heinen, Monique W Jaspers, Helena J van der Pal, Flora E van Leeuwen, Huib N Caron, Ronald B Geskus, Leontien C Kremer
Hospitalization rates over time of childhood cancer survivors (CCS) provide insight into the burden of unfavorable health conditions on CCS and health care resources. The objective of our study was to examine trends in hospitalizations of CCS and risk factors in comparison with the general population. We performed a medical record linkage study of a cohort of 1564 ≥five-year CCS with national registers. We obtained a random sample of the general population matched on year of birth, gender and calendar year per CCS retrieved...
2016: PloS One
Osama Muhammad Maria, Mostafa Shalaby, Alasdair Syme, Nicoletta Eliopoulos, Thierry Muanza
BACKGROUND AIMS: Mesenchymal stromal cells (MSCs) have been used to minimize and repair radiation-induced normal tissue injury in the intestine, salivary gland, liver, skin, lungs and cardiac muscle. This study investigated the ability of adipose tissue-derived MSCs (aMSCs) to minimize and/or repair single dose radiation-induced oral mucositis (RIOM). METHODS: Syngenic phenotypically and functionally characterized BALB/c mouse aMSCs were implanted intraperitoneally in a RIOM mouse model with different dosing protocols...
September 2016: Cytotherapy
Estelle Guerdoux-Ninot, Robert D Kilgour, Chloé Janiszewski, Marta Jarlier, Jocelyne Meuric, Brigitte Poirée, Solange Buzzo, Grégory Ninot, Julie Courraud, Wendy Wismer, Simon Thezenas, Pierre Senesse
PURPOSE: The present study examined patient self-reports of descriptions, experiences and consequences of meal disturbances and food preferences within a cultural context (i.e., French meal traditions) in various treated cancer patients along their disease trajectory. METHODS: Over 800 questionnaires were sent to 20 cancer treatment centres in France. During a 9-month period, 255 questionnaires were received from five centres. Inclusion criteria included those French patients over 18 years of age, could read and understand French, had an Eastern Cooperative Oncology Group score between 0 and 2, experienced treatment-induced nutrition changes and/or had decreased oral intake...
2016: SpringerPlus
Christiane Matuschek, Edwin Bölke, Caroline Geigis, Kai Kammers, Ute Ganswindt, Kathrin Scheckenbach, Stephan Gripp, Jannis Simiantonakis, Thomas K Hoffmann, Jens Greve, Peter Arne Gerber, Klaus Orth, Henning Roeder, Matthias G Hautmann, Wilfried Budach
PURPOSE/OBJECTIVE(S): Intensification of radiotherapy and chemotherapy for head-and-neck cancer (HNC) may lead to increased rates of long term dysphagia as a severe side effect. Mucositis and consequent swallowing problems require artificial nutrition in many HNC patients undergoing radiotherapy or chemoradiation. It is unknown, which predict factors for prophylactic PEG tube insertion appear useful. MATERIALS/METHODS: From an institutional database, 101 patients (72 male, 29 female, mean age 59...
July 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Zhihong Zhang, Yu Zhu, Yun Ling, Lijuan Zhang, Hongwei Wan
Nasogastric tube (NGT) and percutaneous endoscopic gastrostomy were frequently used in the head and neck cancer patients when malnutrition was present. Nevertheless, the evidence was inclusive in terms of the choice and the time of tube placement. The aim of this network meta-analysis was to evaluate the comparative effects of prophylactic percutaneous endoscopic gastrostomy (pPEG), reactive percutaneous endoscopic gastrostomy (rPEG), and NGT in the head and neck cancer patients receiving radiotherapy or chemoradiotherapy...
2016: OncoTargets and Therapy
Leanne K Jackson, Sheila H Ridner, Jie Deng, Carmin Bartow, Kyle Mannion, Ken Niermann, Jill Gilbert, Mary S Dietrich, Anthony J Cmelak, Barbara A Murphy
BACKGROUND: Tumor/treatment-related internal lymphedema (IL) and/or external lymphedema (EL) are associated with functional deficits and increased symptom burden in head and neck cancer patients (HNCP). Previously, we noted association between EL/IL and patient-reported dysphagia using the Vanderbilt Head and Neck Symptom Survey (VHNSS) version 1.0. OBJECTIVE: To determine the relationship between IL/EL and subjective and objective measures of swallowing function...
September 2016: Journal of Palliative Medicine
M Álvarez-Camacho, L Martínez-Michel, S Gonella, R A Scrimger, K P Chu, W V Wismer
BACKGROUND AND AIM: Dietary advice for post treatment head and neck cancer (HNC) patients emphasizes food characteristics of nutritional value and texture, and not patients' characterization of food. The aim of this study was to determine patients' characterization of food. METHODS: Repertory grid interviews were conducted with 19 orally-fed HNC patients between 4 and 10 months post-treatment to characterize foods commonly eaten, avoided and eaten sometimes. Patients compared and rated 12 foods using their own descriptors...
June 2016: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
Yi-Shan Wu, Pao-Yen Lin, Chih-Yen Chien, Fu-Min Fang, Nien-Mu Chiu, Chi-Fa Hung, Yu Lee, Mian-Yoon Chong
OBJECTIVE: We aimed to assess psychiatric morbidities of patients with head and neck cancer (HNC) in a prospective study at pretreatment, and 3 and 6 months after treatment, and to compare their health-related quality of life (HRQL) between those with and without depressive disorders (depression). MATERIALS AND METHODS: Patients with newly diagnosed HNC from a tertiary hospital were recruited into the study. They were assessed for psychiatric morbidities using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition...
2016: Neuropsychiatric Disease and Treatment
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