keyword
https://read.qxmd.com/read/37074487/an-autologous-blood-derived-patch-as-a-hemostatic-agent-evidence-from-thromboelastography-experiments-and-a-porcine-liver-punch-biopsy-model
#21
JOURNAL ARTICLE
Morten P R Eskildsen, Otto Kalliokoski, Marie Boennelycke, Rasmus Lundquist, Annette Settnes, Ellen Loekkegaard
Perioperative bleeding is a common complication in surgeries that increases morbidity, risk of mortality, and leads to increased socioeconomic costs. In this study we investigated a blood-derived autologous combined leukocyte, platelet, and fibrin patch as a new means of activating coagulation and maintaining hemostasis in a surgical setting. We evaluated the effects of an extract derived from the patch on the clotting of human blood in vitro, using thromboelastography (TEG). The autologous blood-derived patch activated hemostasis, seen as a reduced mean activation time compared to both non-activated controls, kaolin-activated samples, and fibrinogen/thrombin-patch-activated samples...
April 19, 2023: Journal of Materials Science. Materials in Medicine
https://read.qxmd.com/read/37073895/hemostatic-profiles-in-dogs-with-sudden-acquired-retinal-degeneration-syndrome
#22
JOURNAL ARTICLE
Alex M Lynch, Laura K Ruterbories, James B Robertson, Katharine F Lunn, Freya M Mowat
BACKGROUND: Sudden acquired retinal degeneration syndrome (SARDS) is a common cause of irreversible blindness in dogs. It bears clinical resemblance to hypercortisolism, which can be associated with hypercoagulability. The role of hypercoagulability in dogs with SARDS is unknown. OBJECTIVE: Determine hemostatic profiles in dogs with SARDS. ANIMALS: Prospective pilot study: Dogs with a history of SARDS (n = 12). Prospective case-control study: Dogs with recent onset of SARDS (n = 7) and age-, breed-, and sex-matched controls (n = 7)...
April 19, 2023: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/37019087/agreement-between-viscoelastic-coagulation-monitor-vcm-teg-5000-and-coagulation-tests-in-critically-ill-patients-a-multicenter-study
#23
MULTICENTER STUDY
Mauro Panigada, Andrea Meli, Andrea Forastieri Molinari, Lorenzo Grazioli, Marco Giani, Daniele Ceriani, Cecilia Bianchi, Maria Teresa Passarelli, Dario Consonni, Giacomo Grasselli
The performance of viscoelastic coagulation monitor (VCM) compared with TEG 5000 (TEG) is unknown. In this multicenter study, the authors evaluated the agreement among VCM/TEG parameters and their relationship with standard coagulation tests in critically ill patients. Viscoelastic coagulation monitor, TEG, and laboratory samples were analyzed simultaneously. Viscoelastic coagulation monitor/TEG agreement was computed by Bland and Altman's plots, association with laboratory parameters was studied with Spearman's correlation coefficient and random-intercept linear models...
June 1, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/36996629/effect-of-the-crosslinking-agent-on-the-biorepulsive-and-mechanical-properties-of-polyglycerol-membranes
#24
JOURNAL ARTICLE
Sebastian Balser, Zhiyong Zhao, Michael Zharnikov, Andreas Terfort
Polyglycerol (PG) based surfaces materials and surfaces are well-established bio-compatible materials. Crosslinking of the dendrimeric molecules via their OH groups improves their mechanical stability up to the point that free-standing materials can be attained. Here, we investigate the effect of different crosslinkers on PG films regarding their biorepulsivity and mechanical properties. For this purpose, PG films with different thicknesses (15, 50 and 100 nm) were prepared by polymerizing glycidol in a ring-opening polymerization onto hydroxyl-terminated Si substrates...
March 24, 2023: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/36978511/paired-analysis-of-d-dimer-and-its-correlated-hemostatic-parameters-in-30-dogs-with-neoplasms-after-tumorectomy
#25
JOURNAL ARTICLE
Chiao-Hsu Ke, Cheng-Chi Liu, Shang-Lin Wang, Chen-Si Lin
Previous studies have reported that dogs with neoplasms had elevated D-dimer levels. However, few studies have addressed whether D-dimer could be an indicator of tumor burden. The clinical significance of paired analysis of pre- and post-operation of D-dimer levels in dogs has rarely been described. The present study investigated the values of D-dimer levels and their correlated hemostatic alterations in dogs with surgically removable benign and malignant tumors. This study analyzed 30 clinically healthy and 30 tumor-bearing dogs and evaluated the hemostatic functions including D-dimer, thromboelastography G (TEG G), fibrinogen, activated partial thromboplastin time (aPTT), prothrombin time, and platelet count...
March 7, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/36933991/interaction-between-platelet-and-fibrinogen-on-clot-strength-in-healthy-patients
#26
JOURNAL ARTICLE
Andrew Maslow, Tracey Cheves, Maurice Frankie Joyce, Patricia Apruzzese, Joseph Sweeney
OBJECTIVE: The purpose of this study was to explore the relationship between platelet concentration (PLT) (× 109 /L) and clot strength measured by thromboelastography maximum amplitude (TEG-MA) in healthy volunteers without a history of coagulation abnormalities. Secondarily, the relationship between fibrinogen (mg/dL) and TEG-MA was analyzed. DESIGN: A prospective study. SETTING: At a university's tertiary-care center. MEASUREMENTS AND MAIN RESULTS: Using whole blood, PLT was reduced in the first part, and hematocrit was reduced in the second part of the study by hemodilution with platelet-rich and -poor plasma...
February 20, 2023: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/36932415/dose-dependent-effect-of-canine-lyophilized-platelet-on-an-in-vitro-hemodilution-model
#27
JOURNAL ARTICLE
Mu-Young Kim, Hyun-Jung Han
The transfusion of stored platelets has emerged as an efficient method for treating dogs with thrombocytopenia. However, the availability of fresh platelets is limited in veterinary medicine due to demanding storage conditions. Lyophilized platelets have long shelf lives and can be easily stored, increasing their accessibility for thrombocytopenic dogs. Due to the lack of research and information on the dose effect, canine lyophilized platelets are used at a clinical dosage without research-based evidence. This study was to evaluate the dose effect of lyophilized canine platelets on blood coagulability...
March 17, 2023: BMC Veterinary Research
https://read.qxmd.com/read/36931905/point-of-care-viscoelastic-hemostatic-assays-in-cardiac-surgery-patients-comparison-of-thromboelastography-6s-thromboelastometry-sigma-and-quantra
#28
JOURNAL ARTICLE
Zoe Demailly, Veronique Wurtz, Virginie Barbay, Elisabeth Surlemont, Vincent Scherrer, Vincent Compère, Paul Billoir, Thomas Clavier, Emmanuel Besnier
OBJECTIVES: Viscoelastic tests allow a reduction in blood product transfusion. Three modern devices are currently available (rotational thromboelastometry [ROTEM] sigma, thromboelastography [TEG] 6S, and Quantra). No study has compared the performances of these 3 devices simultaneously. DESIGN: An observational, nonrandomized cohort study. SETTING: A single-center of cardiac surgery in a university hospital. PARTICIPANTS: A total of 30 consecutive measurements from at least 10 adult patients presenting significant bleeding in the intensive care unit after cardiac surgery INTERVENTION: Viscoelastic tests using ROTEM sigma, TEG 6S, and Quantra were performed concomitantly with conventional coagulation measurements MEASUREMENTS AND MAIN RESULTS: The authors included 16 patients with 31 blood samples...
June 2023: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/36908225/hypofibrinogenemic-massive-transfusion-trauma-patients-experience-worse-outcomes
#29
JOURNAL ARTICLE
Mitchell J Parker, Elizabeth W Crowder, M Victoria P Miles, Kevin N Harrell, Robert A Maxwell
INTRODUCTION: Uncontrolled hemorrhage accounts for up to 40% of trauma-related mortality. Previous reports demonstrate that decreased fibrinogen levels during traumatic hemorrhage are associated with worse outcomes. Cryoprecipitate is used to replace fibrinogen for patients in hemorrhagic shock undergoing massive transfusion (MT), though the optimal ratio of cryoprecipitate to fresh frozen plasma (FFP), packed red blood cells (PRBCs), and platelets remains undefined. The purpose of this study is to investigate the effect of admission fibrinogen level and the use of cryoprecipitate on outcomes in trauma patients undergoing MT...
March 12, 2023: American Surgeon
https://read.qxmd.com/read/36844746/risk-factor-prediction-of-severe-postoperative-acute-kidney-injury-at-stage-3-in-patients-with-acute-type-a-aortic-dissection-using-thromboelastography
#30
JOURNAL ARTICLE
Xin-Liang Guan, Lei Li, Hai-Yang Li, Ming Gong, Hong-Jia Zhang, Xiao-Long Wang
OBJECTIVE: Perioperative blood transfusions and postoperative drainage volume not only are the commonly recognized risk factors for acute kidney injury (AKI) but also are indirect indicators of coagulopathy in patients with acute type A aortic dissection (ATAAD). However, standard laboratory tests fail to accurately reflect and assess the overall coagulopathy profile in patients with ATAAD. Thus, this study aimed to explore the association between the hemostatic system and severe postoperative AKI (stage 3) in patients with ATAAD using thromboelastography (TEG)...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/36828005/changes-in-coagulation-in-cancer-patients-undergoing-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-treatment-hipec-a-systematic-review
#31
JOURNAL ARTICLE
Mikkel Lundbech, Matilde Damsbo, Andreas Engel Krag, Anne-Mette Hvas
Venous thromboembolism and postoperative bleeding are complications of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). The aim of this systematic review was to summarize current knowledge on the effect of cytoreductive surgery with HIPEC on coagulation and fibrinolysis within 10 days after surgery. Studies were identified in PubMed, Embase, and Web of Science on December 12, 2022. Data on biomarkers of coagulation and fibrinolysis measured preoperatively up to the 10th postoperative day were extracted...
February 24, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36694329/estradiol-provokes-hypercoagulability-and-affects-fibrin-biology-a-mechanistic-exploration-of-sex-dimorphisms-in-coagulation
#32
JOURNAL ARTICLE
Julia R Coleman, Ernest E Moore, Lauren Schmitt, Kirk Hansen, Nathan Dow, Kalev Freeman, Mitchell J Cohen, Christopher C Silliman
BACKGROUND: Sex dimorphisms in coagulation are well established, with female-specific hypercoagulability conferring a survival benefit in the setting of trauma-induced coagulopathy (TIC). The mechanism behind these phenomena remains to be elucidated. We hypothesize that estradiol provokes a hypercoagulable profile and alters clot proteomics and fibrin crosslinking. METHODS: Whole blood was collected from healthy adult volunteers (n = 30). A battery of thrombelastography (TEG) assays (native, kaolin, platelet-mapping, functional fibrinogen), whole blood thrombin generation, proteomics, and clot structure architecture (via analysis of fibrin crosslinks and fluorescent fibrinogen-visualized clots) were performed after pre-treatment of the blood with physiologic concentrations of beta-estradiol...
February 1, 2023: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/36675406/are-viscoelastometric-assays-of-old-generation-ready-for-disposal-comment-on-volod-et-al-viscoelastic-hemostatic-assays-a-primer-on-legacy-and-new-generation-devices-j-clin-med-2022-11-860
#33
JOURNAL ARTICLE
Marion Bareille, Thomas Lecompte, François Mullier, Stéphanie Roullet
With the advent of new viscoelastometric hemostatic assay (VHA) devices, with ready-to-use cartridge reagents allowing for their use by people without special laboratory skills, the appreciation of the actual clinical value of VHAs in settings such as severe trauma, post-partum hemorrhage, cardiac surgery and liver transplantation still needs to be fully validated. While two of the newest versions remain based on a 'cup and pin' system (ROTEM® sigma, ClotPro® ), two other new devices (TEG® 6s, Quantra® ) rely on very different technologies: clotting blood is no longer in contact with the probe and challenged by oscillation of one of the components but explored with ultrasound exposure...
January 6, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/36639521/the-impact-of-high-on-treatment-platelet-reactivity-and-fibrinogen-levels-on-ischemic-events-in-patients-with-st-elevation-myocardial-infarction-a-prospective-observational-study
#34
JOURNAL ARTICLE
Yao Yao, Xiaoye Li, Zi Wang, Shikun Xu, Qianzhou Lv
BACKGROUND: After treatment, high residual platelet reactivity (HRPR) is considered as an essential risk factor for recurrent ischemic events. AIM: To evaluate the impact of fibrinogen on HRPR after implantation of emergency drug-eluting stents (DES) in patients treated with aspirin and clopidogrel or ticagrelor due to ST-elevation myocardial infarction (STEMI) and to explore the predictive values of HRPR and fibrinogen for adverse ischemic events at 12 months...
January 13, 2023: International Journal of Clinical Pharmacy
https://read.qxmd.com/read/36551292/microplastic-effects-on-thrombin-fibrinogen-clotting-dynamics-measured-via-turbidity-and-thromboelastography
#35
JOURNAL ARTICLE
Daniela Q Tran, Nathan Stelflug, Abigail Hall, Tanmaye Nallan Chakravarthula, Nathan J Alves
Micro/nanoplastics, whether manufactured or resulting from environmental degradation, can enter the body through ingestion, inhalation, or dermal pathways. Previous research has found that nanoplastics with diameters of ≤100 nm can translocate into the circulatory system in a dose-dependent manner and potentially impact thrombosis and hemostasis. To investigate the direct effects of microplastics on fibrin clot formation, a simplified ex vivo human thrombin/fibrinogen clot model was utilized. The 100 nm polystyrene particles (non-functionalized [nPS] and aminated [aPS]) were preincubated (0-200 µg/mL) with either thrombin or fibrinogen, and fibrin clot formation was characterized via turbidity and thromboelastography (TEG)...
December 13, 2022: Biomolecules
https://read.qxmd.com/read/36513433/point-of-care-coagulation-testing-for-postpartum-haemorrhage
#36
REVIEW
Peter Collins
The use of viscoelastic haemostatic assays (VHAs) to guide blood product replacement during postpartum haemorrhage is expanding. Rotem and TEG devices can be used to detect and treat clinically significant hypofibrinogenaemia, although evidence to support the role of VHAs for guiding fresh frozen plasma and platelet transfusion is less clear. If Rotem/TEG traces are normal, clinicians should investigate for another cause of bleeding, and haemostatic support is not required. Guidelines support the use of VHAs during postpartum haemorrhage as part of locally agreed algorithms...
December 2022: Best Practice & Research. Clinical Anaesthesiology
https://read.qxmd.com/read/36444922/preoperative-thromboelastography-in-the-prediction-of-post-tonsillectomy-hemorrhage-by-coblation-tonsillectomy-a-post-hoc-analysis
#37
RANDOMIZED CONTROLLED TRIAL
Qian Liu, Yanping Zhang, Yanlu Liu
BACKGROUND: Post-tonsillectomy hemorrhage (PTH) affects around 4% of patients after tonsillectomy. We hypothesized that preoperative thromboelastography (TEG) might identify patients at higher risk of PTH. OBJECTIVE: Investigate whether evaluation of coagulation function by preoperative TEG might help to predict PTH after tonsillectomy by coblation tonsillectomy (TE). DESIGN: Post-hoc analysis of randomized controlled study. SETTING: Otolaryngology Department between January 2017 and August 2019...
2022: Annals of Saudi Medicine
https://read.qxmd.com/read/36380826/comparison-of-thromboelastography-devices-teg-%C3%A2-6s-point-of-care-device-vs-teg-%C3%A2-5000-in-pediatric-patients-undergoing-cardiac-surgery
#38
JOURNAL ARTICLE
Sirisha Emani, Vishnu S Emani, Fatoumata B Diallo, Puja Dutta, Gregory S Matte, Meena Nathan, Juan C Ibla, Sitaram M Emani
Thromboelastography (TEG) can predict bleeding in pediatric patients undergoing cardiac surgery. We hypothesized that results obtained from TEG® 5000 correlate with the new point-of-care TEG® 6S system and that TEG® 6S rewarming maximum amplitude (MA) is associated with surrogate endpoints for perioperative bleeding in pediatric patients who underwent complex cardiac surgery. We describe a retrospective study of pediatric (≤18 years) patients who underwent complex cardiac surgery on cardiopulmonary bypass...
March 2022: Journal of Extra-corporeal Technology
https://read.qxmd.com/read/36273811/comparative-retrospective-study-on-the-validity-of-point-of-care-testing-device-for-massive-obstetrical-hemorrhage-dry-hematology-vs-thromboelastography
#39
JOURNAL ARTICLE
Eishin Nakamura, Shigetaka Matsunaga, Akihiko Kikuchi, Yasushi Takai
BACKGROUND: Early recognition of hypofibrinogenemia and prompt initiation of transfusion therapy in patients with massive obstetrical hemorrhage can improve prognosis. There are reports on the usefulness of point-of-care testing, which provides quicker test results compared with fibrinogen measurements using the conventional Clauss method. OBJECTIVE: This study aimed to compare and investigate the diagnostic accuracy of dry hematology and thromboelastography in point-of-care testing for the diagnosis of hypofibrinogenemia...
January 2023: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/36249158/pattern-of-conventional-coagulation-and-thromboelastographic-parameters-in-patients-with-covid-19-diseases-and-association-of-covid-associated-coagulopathy-with-mortality-in-intensive-care-unit
#40
JOURNAL ARTICLE
Awale Rupali Balchandra, Tanmoy Ghatak, Sukhen Samanta, Ratender K Singh, Anupam Verma, Prabhakar Mishra, Rajendra Chaudhary, Alok Nath
BACKGROUND: Knowledge of underlying pathophysiology of coagulopathy is evolving and the pattern of coagulation parameters in coronavirus disease 2019 (COVID-19)-associated diseases is still not very clear. AIMS: In the present study, we aimed to find out the pattern and distribution of conventional coagulation parameters and thromboelastographic (TEG) parameters in COVID-19-associated coagulopathy (CAC) in survivors and nonsurvivors at 28 days. SETTING AND DESIGN: The present prospective observational study was conducted at a tertiary care COVID-19 intensive care unit (ICU) facility from March 21, 2020, to July 15, 2021...
2022: Anesthesia, Essays and Researches
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