keyword
MENU ▼
Read by QxMD icon Read
search

(NOS)and(nitric oxide synthase)

keyword
https://www.readbyqxmd.com/read/28328190/effects-of-nitric-oxide-inhibitors-in-mice-with-bladder-outlet-obstruction
#1
Marcy Lancia Pereira, Carlos Arturo Levi D'ancona, Julio Alejandro Rojas-Moscoso, Antonio Celso Saragossa Ramos, Fabiola Zakia Monica, Edson Antunes
PURPOSE: To investigate the lower urinary tract changes in mice treated with L-NAME, a non-selective competitive inhibitor of nitric oxide synthase (NOS), or aminoguanidine, a competitive inhibitor of inducible nitric oxide synthase (iNOS), after 5 weeks of partial bladder outlet obstruction (BOO), in order to evaluate the role of constitutive and non-constitutive NOS in the pathogenesis of this experimental condition. MATERIALS AND METHODS: C57BL6 male mice were partially obstructed and randomly allocated into 6 groups: Sham, Sham + L-NAME, Sham + aminoguanidine, BOO, BOO + L-NAME and BOO + aminoguanidine...
March 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28325791/individual-variations-in-nitric-oxide-synthase-dependent-sweating-in-young-and-older-males-during-exercise-in-the-heat-role-of-aerobic-power
#2
Tatsuro Amano, Naoto Fujii, Jeffrey C Louie, Robert D Meade, Glen P Kenny
We evaluated the association between aerobic power (defined by peak oxygen consumption; VO2peak) and the contribution of nitric oxide synthase (NOS) to the sweating response in young and older individuals during exercise in the heat. Data from 44 young (24 ± 1 years) and 48 older (61 ± 2 years) males with mean VO2peak of 47.8 ± 2.4 (range, 28.0-62.3) and 39.1 ± 2.3 (range, 26.4-55.7) mLO2 kg(-1) min(-1), respectively, were compiled from our prior studies. Participants performed two 15- to 30-min bouts of exercise at a fixed rate of metabolic heat production of 400 or 500 W, each separated by 15-20 min recovery in the heat (35°C, relative humidity of 20%)...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28325363/the-role-and-prognostic-value-of-inducible-nitric-oxide-synthase-inos-and-interleukin-33-il-33-in-serous-and-mucinous-epithelial-ovarian-tumours
#3
Eman M Saied, Nour M El-Etreby
Understanding different mechanisms contributing to the aggressive behaviour of epithelial ovarian cancer (EOC) is a large challenge. Interaction between inflammation, immunity and carcinogenesis occurs in different cancers; however, the potential roles of different molecules involved in these processes in relation to ovarian carcinogenesis were not fully investigated. Inducible nitric oxide synthase (iNOS) and interleukin-33 (IL-33) are implicated in carcinogenesis. iNOS is an NOS isoform that generates nitric oxide, which plays important roles in various stages of carcinogenesis...
April 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28324760/trpv1-agonism-inhibits-endothelial-cell-inflammation-via-activation-of-enos-no-pathway
#4
Youping Wang, Lin Cui, Hui Xu, Suxiao Liu, Feiyun Zhu, Fengna Yan, Si Shen, Mingjun Zhu
BACKGROUND AND AIMS: Transient receptor potential vanilloid type 1 channel (TRPV1) is found to be expressed in endothelial cells (ECs) and activate endothelial nitric oxide synthase (eNOS). Recent studies implicate TRPV1 in attenuating inflammatory responses. However, the mechanisms underlying the beneficial effects remain unclear. In this study, we investigated whether TRPV1 suppresses inflammatory responses of ECs via eNOS/NO pathway. METHODS: Human umbilical vein endothelial cells (HUVECs) and renal microvascular endothelial cells (MVECs) isolated from deoxycorticosterone (DOCA)-salt hypertensive mice were cultured in the presence of capsaicin (CAP, a specific TRPV1 agonist) with or without the specific inhibitor of TRPV1, NOS, or Ca(2+)-dependent phosphatidylinositol 3-kinase (PI3K)/Akt pathway, before lipopolysaccharide (LPS) stimulation...
March 10, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28303482/extracellular-superoxide-dismutase-is-necessary-to-maintain-renal-blood-flow-during-sepsis-development
#5
Larissa Constantino, Letícia Selinger Galant, Francieli Vuolo, Karla Lorena Guarido, Luiza Wilges Kist, Giovanna Medeiros Tavares de Oliveira, Matheus Augusto de Bittencourt Pasquali, Cláudio Teodoro de Souza, José Eduardo da Silva-Santos, Maurício Reis Bogo, José Cláudio Fonseca Moreira, Cristiane Ritter, Felipe Dal-Pizzol
BACKGROUND: Extracellular superoxide dismutase (ECSOD) protects nitric oxide (NO) bioavailability by decreasing superoxide levels and preventing peroxynitrite generation, which is important in maintaining renal blood flow and in preventing acute kidney injury. However, the profile of ECSOD expression after sepsis is not fully understood. Therefore, we intended to evaluate the content and gene expression of superoxide dismutase (SOD) isoforms in the renal artery and their relation to renal blood flow...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28302706/acclimatization-of-the-systemic-microcirculation-to-alveolar-hypoxia-is-mediated-by-inos-dependent-increased-nitric-oxide-availability
#6
Alfred J Casillan, Jie Chao, John G Wood, Norberto C Gonzalez
Rats breathing 10% O2 show a rapid and widespread systemic microvascular inflammation that results from nitric oxide (NO) depletion secondary to increased reactive O2 species (ROS) generation. The inflammation eventually resolves and the microcirculation becomes resistant to more severe hypoxia. These experiments were directed to determine the mechanisms underlying this microvascular acclimatization process. Intravital microscopy of the mesentery showed that after three weeks of hypoxia (PB ~380 Torr, inspired PO2 ~ 68-70 Torr) rats showed no evidence of inflammation; however, treatment with the inducible NO synthase (iNOS) inhibitor L-N(6)-(1-Iminoethyl) lysine dihydrochloride (L-NIL) led to ROS generation, leukocyte-endothelial adherence and emigration, and increased vascular permeability...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28299403/effects-of-ifn-%C3%AE-1a-and-ifn-%C3%AE-1b-treatment-on-the-expression-of-cytokines-inducible-nos-nos-type-ii-and-myelin-proteins-in-animal-model-of-multiple-sclerosis
#7
Natalia Lubina-Dąbrowska, Adam Stepień, Grzegorz Sulkowski, Beata Dąbrowska-Bouta, Józef Langfort, Małgorzata Chalimoniuk
The aim of this study was to investigate the effects of interferon (IFN)-β1a and IFN-β1b treatment on inflammatory factors and myelin protein levels in the brain cortex of the Lewis rat experimental autoimmune encephalomyelitis (EAE), animal model of multiple sclerosis. To induce EAE, rat were immunized with inoculums containing spinal cord guinea pig homogenized in phosphate-buffered saline and emulsified in Freund's complete adjuvant containing 110 µg of the appropriate antigen in 100 µl of an emulsion and additionally 4-mg/ml Mycobacterium tuberculosis (H37Ra)...
March 15, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28299311/immunostimulated-arginase-ii-expression-in-intestinal-epithelial-cells-reduces-nitric-oxide-production-and-apoptosis
#8
Maria M Talavera, Sushma Nuthakki, Hongmei Cui, Yi Jin, Yusen Liu, Leif D Nelin
Increased production of nitric oxide (NO) and subsequent local cytotoxicity to mucosal epithelial cells has been proposed as a putative mechanism involved in the development of necrotizing enterocolitis (NEC). Intestinal epithelial cells (IECs) metabolize L-arginine to either nitric oxide (NO) by NO synthase (NOS) or to L-ornithine and urea by arginase. L-ornithine is the first step in polyamine synthesis important for cell proliferation, while NO production can lead to apoptosis. We hypothesized that in IECs immunostimulation increases both NOS and arginase expression, and that arginase activity mitigates NO production and apoptosis...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28298952/insights-for-oxidative-stress-and-mtor-signaling-in-myocardial-ischemia-reperfusion-injury-under-diabetes
#9
REVIEW
Dajun Zhao, Jian Yang, Lifang Yang
Diabetes mellitus (DM) displays a high morbidity. The diabetic heart is susceptible to myocardial ischemia/reperfusion (MI/R) injury. Impaired activation of prosurvival pathways, endoplasmic reticulum (ER) stress, increased basal oxidative state, and decreased antioxidant defense and autophagy may render diabetic hearts more vulnerable to MI/R injury. Oxidative stress and mTOR signaling crucially regulate cardiometabolism, affecting MI/R injury under diabetes. Producing reactive oxygen species (ROS) and reactive nitrogen species (RNS), uncoupling nitric oxide synthase (NOS), and disturbing the mitochondrial quality control may be three major mechanisms of oxidative stress...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28298655/dual-nep-ece-inhibition-improves-endothelial-function-in-mesenteric-resistance-arteries-of-32-week-old-shr
#10
Pieter Lemkens, Leon Ja Spijkers, Merlijn J Meens, Jelly Nelissen, Ben Janssen, Stephan Lm Peters, Paul Mh Schiffers, Jo Gr De Mey
Endothelin 1 (ET-1), a potent vasoconstrictor, pro-mitogenic and pro-inflammatory peptide, may promote development of endothelial dysfunction and arterial remodeling. ET-1 can be formed through cleavage of big-ET-1 by endothelin-converting enzyme (ECE) or neutral endopeptidase (NEP). We investigated whether chronic treatment with the novel dual NEP/ECE inhibitor SOL1 improves functional and structural properties of resistance-sized arteries of 32-week-old male spontaneously hypertensive rats (SHR). SHR received a chronic 4-week treatment with SOL1, losartan or hydralazine...
March 16, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28294385/potential-excitatory-role-of-nitric-oxide-on-2-deoxy-d-glucose-induced-gastric-motility-in-rats
#11
A M Sevgili, Z D Balkanci, A Erdem
Previous studies have shown that 2-deoxy-d-glucose (2-DG) increases gastric motility via the vagus nerve, but the underlying mechanism remains elusive. Since nitric oxide (NO) is involved in gastric motility, a possible interplay between 2-DG and NO can be suggested. In the present study, Wistar rats (250-350 g) of both sexes were intravenously injected with 2-DG (200 mg·kg(-1) ), and the effects of the intravenous injection of the nitric oxide synthase (NOS) inhibitors; nitro-l-arginine methyl ester (l-NAME, 10 mg·kg(-1) ) and N(ω) -nitro-l-arginine (l-NNA, 10 mg·kg(-1) ) were investigated...
March 13, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28294182/asymmetric-dimethylarginine-and-all-cause-mortality-a-systematic-review-and-meta-analysis
#12
Shaoli Zhou, Qianqian Zhu, Xiang Li, Chaojin Chen, Jiping Liu, Yuping Ye, Ying Ruan, Ziqing Hei
Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), impairs the beneficial effect of NO. The predictive value of ADMA for all-cause mortality remains controversial, though it is important in the development of cardiovascular disease (CVD) and progression to dialysis in renal disease. This systematic review and meta-analysis was conducted to investigate the association between circulating ADMA and all-cause mortality. Studies with data pertinent to the association between circulating ADMA and all-cause mortality were reviewed and OR, HR or RR with 95% CI derived from multivariate Cox's proportional-hazards analysis were extracted...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28285332/the-role-of-l-arginine-l-homoarginine-nitric-oxide-pathway-for-aortic-distensibility-and-intima-media-thickness-in-stroke-patients
#13
Arash Haghikia, Georgi Radoslavov Yanchev, Arslan Arinc Kayacelebi, Erik Hanff, Nils Bledau, Christian Widera, Kristina Sonnenschein, Aiden Haghikia, Karin Weissenborn, Johann Bauersachs, Udo Bavendiek, Dimitrios Tsikas
Asymmetric dimethylarginine (ADMA) and L-homoarginine (hArg) are L-arginine (Arg) metabolites derived from different pathways. Protein arginine N-methyltransferase (PRMT) and subsequent proteolysis of proteins containing methylarginine residues release ADMA. Arginine:glycine amidinotransferase (AGAT) converts Arg to hArg and guanidinoacetate (GAA). While high concentrations of ADMA and low concentrations of hArg in the blood have been established as cardiovascular risk markers, the cardiovascular relevance of GAA is still unexplored...
March 11, 2017: Amino Acids
https://www.readbyqxmd.com/read/28282293/preliminary-phytochemical-analysis-and-evaluation-of-antioxidant-cytotoxic-and-inhibition-of-lipopolysaccaride-induced-nos-inos-expression-in-balb-c-mice-liver-by-ziziphus-oenoplia-mill-fruit
#14
Ramaraj Thirugnanasampandan, Gunasekar Ramya, Gunasekaran Bhuvaneswari, Srinivasan Aravindh, Suresh Vaishnavi, Madhusudhanan Gogulramnath
BACKGROUND: Ziziphus oenoplia Mill. is an ethnomedicinal plant and its fruit has been traditionally used by Puliar tribes of Anamalai Hills, Tamil Nadu, India to treat various ailments. Phytochemical analysis, antioxidant, cytotoxic and inducible nitric oxide synthase (iNOS) gene downregulation activities of Z. oenoplia fruit (ZOF) were studied. METHODS: To explore bioactive compounds present in the ripened fruits, high-performance thin-layer chromatography (HPTLC) and gas chromatography/mass spectrometry (GC-MS) analysis were done...
March 10, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28275829/endothelial-nitric-oxide-synthase-in-rat-brain-is-downregulated-by-sub-chronic-antidepressant-treatment
#15
Yuta Yoshino, Shinichiro Ochi, Kiyohiro Yamazaki, Shunsuke Nakata, Jun-Ichi Iga, Shu-Ichi Ueno
BACKGROUND: Nitric oxide (NO) is a neurotransmitter that may be related to major depressive disorder (MDD) because the selective neuronal NO synthase (NOS) inhibitor, 7-nitroindazole, induces a dose-dependent antidepressant-like effect. NO modulates major neurotransmitters involved in the neurobiology of MDD, such as norepinephrine, serotonin, dopamine, and glutamate. In this study, we investigated the effects of antidepressants as NO modulators in acute and sub-chronic treatments. METHODS: Rats were injected with the SSRI paroxetine (PAR, 10 mg/kg), the SNRI milnacipran (MIL, 30 mg/kg), or the NaSSA mirtazapine (MIR, 10 mg/kg) for acute (1 h) or sub-chronic (3 weeks) treatment prior to analysis of nine brain regions (frontal cortex, temporal cortex, striatum, thalamus, hippocampus, midbrain, pons, cerebellum, and olfactory bulb)...
March 8, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28274930/nitric-oxide-reduces-paracellular-resistance-in-rat-thick-ascending-limbs-by-increasing-na-and-cl-permeabilities
#16
Casandra Margarita Monzon, Rossana Occhipinti, Omar Pedro Pignataro, Jeffrey L Garvin
About 50% of the Na+ reabsorbed in thick ascending limbs traverses the paracellular pathway. Nitric oxide (NO) reduces the permselectivity of this pathway via cGMP, but its effects on absolute Na(+) (PNa(+)) and Cl(-) (PCl(-)) permeabilities are unknown. To address this, we measured the effect L-arginine (0.5mmol/L; NO synthase substrate) and cGMP (0.5mmol/L) on PNa(+) and PCl(-) calculated from transepithelial resistance (Rt) and PNa(+)/PCl(-) Rt was 7722±1554 ohm-cm in the control period and 6318±1757 ohm-cm after L-arginine treatment (p<0...
March 8, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28271565/prostacyclin-does-not-affect-sweating-but-induces-skin-vasodilatation-to-a-greater-extent-in-older-versus-younger-women-roles-of-no-and-kca-channels
#17
Naoto Fujii, Brendan D McNeely, Takeshi Nishiyasu, Glen P Kenny
We previously reported that prostacyclin induces cutaneous vasodilatation, but not sweating, in younger and older men. Further, we demonstrated that nitric oxide synthase (NOS) and calcium-activated potassium (KCa ) channels contribute to the prostacyclin-induced cutaneous vasodilatation in younger men, although these contributions are diminished in older men. Given the effects of ageing may differ between men and women, the above results cannot be simply applied to women. In this study, cutaneous vascular conductance (CVC) and sweat rate were evaluated in younger (22 ± 3 years) and older (55 ± 7 years) women (10 per group) at four intradermal forearm skin sites treated with either: (1) lactated Ringers without any drug (Control), (2) 10 mm L-NNA, a non-specific NOS inhibitor, (3) 50 mm tetraethylammonium (TEA), a non-specific KCa channel blocker, or (4) 10 mm L-NNA + 50 mm TEA...
March 7, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28268225/pattern-of-nitrergic-neuronal-system-organization-in-the-brain-of-two-holostean-fishes-actinopterygii-ginglymodi
#18
Jesús M López, Daniel Lozano, Lorena Morales, Agustín González
The study of the nitrergic system, formed by the networks of neurons containing the enzyme nitric oxide synthase (NOS), has been extremely useful in unraveling neuroanatomical features of the organization of the central nervous system of vertebrates. Thus, data are available for representatives of most vertebrate classes and, in particular, several studies have detailed the organization of this system in teleosts. In contrast, no information is available regarding this neurotransmission system in the brains of holosteans, an early diverged and poorly understood group of actinopterygian fishes, currently considered a sister group of teleosts that contains only 8 species...
March 8, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28265771/expression-dynamics-of-hsp90-and-nitric-oxide-synthase-nos-isoforms-during-heat-stress-acclimation-in-tharparkar-cattle
#19
Jaya Bharati, S S Dangi, S Bag, V P Maurya, G Singh, P Kumar, M Sarkar
Six male Tharparkar cattle of 2-3 years old were selected for the study. After 15-day acclimation at thermoneutral zone (TNZ) in psychrometric chamber, animals were exposed at 42 °C for 6 h up to 23 days followed by 12 days of recovery period. Blood samples were collected during control period at TNZ (days 1, 5, and 12), after heat stress exposure (day 1, immediate heat stress acclimation (IHSA); days 2 to 10, short-term heat stress acclimation (STHSA); days 15 to 23, long-term heat stress acclimation (LTHSA); days 7 and 12, recovery period), and peripheral blood mononuclear cells (PBMCs) were isolated for RNA and protein extraction...
March 7, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28261254/interaction-of-polyamines-abscisic-acid-nitric-oxide-and-hydrogen-peroxide-under-chilling-stress-in-tomato-lycopersicon-esculentum-mill-seedlings
#20
Qiannan Diao, Yongjun Song, Dongmei Shi, Hongyan Qi
Polyamines (PAs) play a vital role in the responses of higher plants to abiotic stresses. However, only a limited number of studies have examined the interplay between PAs and signal molecules. The aim of this study was to elucidate the cross-talk among PAs, abscisic acid (ABA), nitric oxide (NO), and hydrogen peroxide (H2O2) under chilling stress conditions using tomato seedlings [(Lycopersicon esculentum Mill.) cv. Moneymaker]. The study showed that during chilling stress (4°C; 0, 12, and 24 h), the application of spermidine (Spd) and spermine (Spm) elevated NO and H2O2 levels, enhanced nitrite reductase (NR), nitric oxide synthase (NOS)-like, and polyamine oxidase activities, and upregulated LeNR relative expression, but did not influence LeNOS1 expression...
2017: Frontiers in Plant Science
keyword
keyword
96012
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"