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lyophilized plasma

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https://www.readbyqxmd.com/read/29401352/fibrinogen-concentrate-in-the-special-operations-forces-environment
#1
Steven Sanders, Homer Tien, Jeannie Callum, Barto Nascimento, Henry Peng, Chris Funk, Joanne Schmid, Sandro Rizoli, Shawn Rhind, Andrew Beckett
Introduction: Hemorrhage is the most common cause of death among Special Operations Force (SOF) soldiers. Bringing remote damage control resuscitation into the far-forward combat environment is logistically challenging, as it requires blood products that generally require a robust cold chain. Alternatively, lyophilized products such as fibrinogen concentrate, which does not require thawing or blood group compatibility testing before use, might be advantageous in damage control resuscitation in the battlefield...
January 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29394283/lyophilized-plasma-attenuates-vascular-permeability-inflammation-and-lung-injury-in-hemorrhagic-shock
#2
Shibani Pati, Zhanglong Peng, Katherine Wataha, Byron Miyazawa, Daniel R Potter, Rosemary A Kozar
In severe trauma and hemorrhage the early and empiric use of fresh frozen plasma (FFP) is associated with decreased morbidity and mortality. However, utilization of FFP comes with the significant burden of shipping and storage of frozen blood products. Dried or lyophilized plasma (LP) can be stored at room temperature, transported easily, reconstituted rapidly with ready availability in remote and austere environments. We have previously demonstrated that FFP mitigates the endothelial injury that ensues after hemorrhagic shock (HS)...
2018: PloS One
https://www.readbyqxmd.com/read/29369904/efficacy-of-lyophilised-platelet-rich-plasma-powder-on-healing-rate-in-patients-with-deep-second-degree-burn-injury-a-prospective-double-blind-randomized-clinical-trial
#3
Chi-Yung Yeung, Pai-Shan Hsieh, Lin-Gwei Wei, Li-Chuan Hsia, Lien-Guo Dai, Keng-Yen Fu, Niann-Tzyy Dai
Platelet-rich plasma (PRP) is a kind of plasma that is rich in platelets after processing. It includes various growth factors and cytokines, which speed up the process of wound healing and hemostasis. The PRP solution used in this study is diluted from lyophilized PRP powder, which decreased the possibility of contamination, facilitated the storage, and prolonged the storage life. From in vitro fibroblast proliferation testing, the numbers of PRP supplement were performed for 1, 4, and 7 times by continuous replacement of culture medium each day...
February 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29336864/biochemical-characterization-stability-and-pathogen-safety-of-a-new-fibrinogen-concentrate-fibryga%C3%A2
#4
Petra M Schulz, Werner Gehringer, Sabine Nöhring, Sebastian Müller, Torben Schmidt, Stephanie Kekeiss-Schertler, Cristina Solomon, Katharina Pock, Jürgen Römisch
Fibryga® is a new lyophilized fibrinogen concentrate for intravenous use for the treatment of congenital fibrinogen deficiency. fibryga® is produced from pooled human plasma and the final product is characterized by high purity, integrity, and pathogen safety. Functional activity of fibrinogen was demonstrated by cross-linking studies and thromboelastometry; integrity of the fibrinogen molecule was demonstrated by size exclusion chromatography and the detection of only trace amounts of activation markers in the final product...
January 11, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29334571/use-of-french-lyophilized-plasma-transfusion-in-severe-trauma-patients-is-associated-with-an-early-plasma-transfusion-and-early-transfusion-ratio-improvement
#5
Cédric Nguyen, Julien Bordes, Pierre-Julien Cungi, Pierre Esnault, Michael Cardinale, Quentin Mathais, Jean Cotte, Sébastien Beaume, Anne Sailliol, Bertrand Prunet, Eric Meaudre
BACKGROUND: Early transfusion of high ratio of fresh frozen plasma (FFP) and red blood cells (RBC) is associated with mortality reduction. However, time to reach high ratio is limited by the need to thaw the FFP. French lyophilized plasma (FLYP) used by French army and available in military teaching hospital does not need to be thawed and is immediately available. We hypothesize that the use of FLYP may reduce time to reach a plasma:RBC ratio of 1/1. METHODS: A retrospective study performed in a Level 1 trauma center between January 2012 and December 2015...
January 12, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29287072/a-highly-stable-blood-meal-alternative-for-rearing-aedes-and-anopheles-mosquitoes
#6
Ted Baughman, Chelsea Peterson, Corrie Ortega, Sarah R Preston, Christopher Paton, Jessica Williams, Amy Guy, Gavin Omodei, Brian Johnson, Helen Williams, Scott L O'Neill, Scott A Ritchie, Stephen L Dobson, Damian Madan
We investigated alternatives to whole blood for blood feeding of mosquitoes with a focus on improved stability and compatibility with mass rearing programs. In contrast to whole blood, an artificial blood diet of ATP-supplemented plasma was effective in maintaining mosquito populations and was compatible with storage for extended periods refrigerated, frozen, and as a lyophilized powder. The plasma ATP diet supported rearing of both Anopheles and Aedes mosquitoes. It was also effective in rearing Wolbachia-infected Aedes mosquitoes, suggesting compatibility with vector control efforts...
December 29, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29274254/french-lyophilized-plasma-versus-fresh-frozen-plasma%C3%A2-for-the-initial-management-of-trauma-induced-coagulopathy-a-randomized-open-label-trial
#7
Delphine Garrigue, Anne Godier, Alexandre Glacet, Julien Labreuche, Eric Kipnis, Camille Paris, Alain Duhamel, Eric Resch, Anne Bauters, François Machuron, Pascale Renom, Patrick Goldstein, Benoit Tavernier, Anne Sailliol, Sophie Susen
BACKGROUND: Guidelines recommend to begin haemostatic resuscitation immediately in trauma patients. We aimed to investigate if French Lyophilised Plasma (FLyP) was more effective than Fresh Frozen Plasma (FFP) for the initial management of the trauma-induced-coagulopathy. METHODS: In an open-label, phase 3, randomized trial (NCT02750150), we enrolled adult trauma patients requiring an emergency pack of 4 plasma units within 6 hours of injury. We randomly assigned patients to receive 4-FLyP units or 4-FFP units...
December 23, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29248530/stability-of-hepatitis-c-virus-rna-and-anti-hcv-antibody-in-air-dried-and-freeze-dried-human-plasma-samples
#8
Amanda Poe, Ngocvien Thi Duong, Kanwar Bedi, Maja Kodani
Diagnosis of hepatitis C virus (HCV) infection is based on testing for antibodies to HCV (anti-HCV), hepatitis C core antigen (HCV cAg) and HCV RNA. To ensure quality control (QC) and quality assurance (QA), proficiency panels are provided by reference laboratories and various international organizations, requiring costly dry ice shipments to maintain specimen integrity. Alternative methods of specimen preservation and transport can save on shipping and handling and help in improving diagnostics by facilitating QA/QC of various laboratories especially in resource limited countries...
December 14, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/29248187/early-transfusion-on-battlefield-before-admission-to-role-2-a-preliminary-observational-study-during-barkhane-operation-in-sahel
#9
V Vitalis, C Carfantan, A Montcriol, S Peyrefitte, A Luft, T Pouget, A Sailliol, S Ausset, E Meaudre, J Bordes
INTRODUCTION: Haemorrage is the leading cause of death after combat related injuries and bleeding management is the cornerstone of management of these casualties. French armed forces are deployed in Barkhane operation in the Sahel-Saharan Strip who represents an immense area. Since this constraint implies evacuation times beyond doctrinal timelines, an institutional decision has been made to deploy blood products on the battlefield and transfuse casualties before role 2 admission if indicated...
November 23, 2017: Injury
https://www.readbyqxmd.com/read/29231163/norbuprenorphine-and-respiratory-depression-exploratory-analyses-with-new-lyophilized-buprenorphine-and-sublingual-buprenorphine%C3%A2
#10
John Strang, Alastair Knight, Shelagh Baillie, Kylie Reed, Karolina Bogdanowicz, James Bell
OBJECTIVES: To investigate plasma levels of buprenorphine and norbuprenorphine and their relationship to respiratory depression. MATERIALS AND METHODS: Opioid-dependent subjects were randomized 2 : 1 to novel lyophilized rapid-disintegrating tablet ("bup-lyo") or standard sublingual buprenorphine tablet ("bup-SL"). Measurements included oximetry scores and linked plasma buprenorphine and norbuprenorphine levels. RESULTS: Respiratory depression (cumulative duration of SpO2 < 90% over 30-minute periods) increased with corresponding exposure levels (AUC30 min) of buprenorphine and particularly with norbuprenorphine...
December 12, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29228824/development-of-novel-bioadhesive-granisetron-hydrochloride-spanlastic-gel-and-insert-for-brain-targeting-and-study-their-effects-on-rats
#11
Rehab Abdelmonem, Mohamed El Nabarawi, Alshaimaa Attia
The aim of this study was to formulate granisetron hydrochloride (GH) spanlastic in mucoadhesive gels and lyophilized inserts for intranasal administration to improve GH bioavailability and brain targeting. Carpapol 934 and HPMC were incorporated in GH spanlastic in nasal gels (GHSpNGs). Gelatin and HPMC as matrix former, glycine as a collapse protecting and mannitol as an insert filler and sweeting agent were used to prepare GH spanlastic loaded in lyophilized inserts (GHSpNIs). The prepared GHSpNGs were characterized for pH measurement, drug content, rheology, and in vitro drug release...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29196002/in-vitro-and-in-vivo-assessment-of-anti-hyperglycemic-and-antioxidant-effects-of-oak-leaves-quercus-convallata-and-quercus-arizonica-infusions-and-fermented-beverages
#12
Claudia I Gamboa-Gómez, Luis E Simental-Mendía, Rubén F González-Laredo, Esteban J Alcantar-Orozco, Victor H Monserrat-Juarez, Julio C Ramírez-España, Jose Alberto Gallegos-Infante, Martha R Moreno-Jiménez, Nuria E Rocha-Guzmán
The aim of this study was to evaluate the anti-hyperglycemic and antioxidant effects of oak leaves infusions and fermented beverages from Quercus convallata and Q. arizonica in vitro and in vivo. Female C57BL/6 mice fed with high saturated fat and fructose diet-induced obesity were treated with oak leaves beverages (200 μL/per day equivalent to 15mg of lyophilized sample/Kg of body weight for infusions and 31mg of lyophilized sample/Kg of body weight for fermented beverages) for 3months and an oral glucose tolerance test (OGTT) was performed...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29120370/amorphous-solid-dispersion-of-epigallocatechin-gallate-for-enhanced-physical-stability-and-controlled-release
#13
Yizheng Cao, Jing Teng, Jon Selbo
Epigallocatechin gallate (EGCG) has been recognized as the most prominent green tea extract due to its healthy influences. The high instability and low bioavailability, however, strongly limit its utilization in food and drug industries. This work, for the first time, develops amorphous solid dispersion of EGCG to enhance its bioavailability and physical stability. Four commonly used polymeric excipients are found to be compatible with EGCG in water-dioxane mixtures via a stepwise mixing method aided by vigorous mechanical interference...
November 9, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29096375/solid-lipid-nanoparticles-for-delivery-of-andrographolide-across-the-blood-brain-barrier-in-vitro-and-in-vivo-evaluation
#14
Giulia Graverini, Vieri Piazzini, Elisa Landucci, Daniela Pantano, Pamela Nardiello, Fiorella Casamenti, Domenico E Pellegrini-Giampietro, Anna Rita Bilia, Maria Camilla Bergonzi
Andrographolide is a major diterpenoid of Andrographis paniculata and possesses several biological activities, including protection against oxidative stress mediated neurotoxicity, inflammation-mediated neurodegeneration, and cerebral ischemia. However, this molecule shows low bioavailability, poor water solubility, and high chemical and metabolic instability. The present study reports preparation of solid lipid nanoparticles (SLN) to deliver andrographolide (AG) into the brain. SLN were prepared using Compritol 888 ATO as solid lipid and Brij 78 as surfactant and applying emulsion/evaporation/solidifying method as preparative procedure...
October 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29080620/comparison-of-hypotensive-diuretic-and-renal-effects-between-cladodes-of-opuntia-ficus-indica-and-furosemide
#15
Meryem Bakour, Noori Al-Waili, Redouan El-Haskoury, Nawal El-Menyiy, Thia Al-Waili, Ali Al-Waili, Badiaa Lyoussi
OBJECTIVE: To investigate the diuretic, hypotensive and renal effect of Opuntia ficus-indica in two different species in oral and intravenous administration. METHODS: Diuretic activity was evaluated in rats with the plant cladode gel and aqueous extract administrated orally, and was evaluated in rabbits with plant extract administered intravenously. Single and repeated doses of cladode gel or aqueous extract of cladode were tested. Urine volume and blood and urine creatinine, sodium and potassium were measured, and creatinine clearance was calculated...
September 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29072333/large-scale-purification-of-high-purity-%C3%AE-1-antitrypsin-from-cohn-fraction-iv-with-virus-inactivation-by-solvent-detergent-and-dry-heat-treatment
#16
Chaoji Huangfu, Jinchao Zhang, Yuyuan Ma, Junting Jia, Jingxuan Li, Maomin Lv, Xiaowei Ma, Xiong Zhao, Jingang Zhang
α1-antitrypsin (AAT) is widely used to treat patients with congenital AAT deficiency. Cohn Fraction IV (Cohn F IV) is normally discarded during the manufacturing process of albumin but contains approximately 33% of plasma AAT. We established a new process for large-scale purification of AAT from it. LC-ESI-MS/MS and HPLC were applied for qualitative identification and composition analysis, respectively. Stabilizers were optimized for AAT activity protection during lyophilization and dry-heat. Virus inactivation by dry-heat and solvent/detergent (S/D) was validated on a range of viruses...
October 26, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/29039327/formulation-of-lyophilized-single-vial-kit-of-n-n-ethylene-l-dicysteine-ec-for-labeling-with-99m-tc-ii-radiochemical-and-clinical-evaluation-as-a-renal-tubular-agent-in-comparison-with-99m-tc-mag3
#17
Anjum Afshan, Mohammad Sohaib, Mohammad Jehangir
A Technetium (99m)Tc labeled lyophilized single component kit of N-N-ethylene-I-dicysteine (EC) is developed to replace multiple step kit developed by others. The aim of study is to formulate a radionuclide that is easy to prepare, has rapid plasma clearance, produce high quality images and is an affective alternative to radioiodine labeled orthoiodohippurate, which has been remained the physiological 'gold standard' since long time. To achieve this goal, the systematically varied key parameters such as pH, the use of reducing agents, stabilizers and additives are optimized to obtain maximum radiochemical purity and optimum biodistribution in non human and human primates...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29034197/characterization-of-calcined-jade-and-its-immunomodulatory-effect-on-macrophage-isolated-from-swiss-albino-mice
#18
Asif Elahi, Deeba S Jairajpuri, Farah Khan
Calcined Jade (CJ) is a metasilicate frequently used in traditional system of medicine as tonic to vital organs with several other pharmacological activities. X-ray powder diffraction (XRPD), inductively coupled plasma mass spectrometry (ICP-MS), atomic absorption spectroscopy (AAS) and CHNS analyzer techniques were used to characterize CJ sample. CJ was administered orally to Swiss albino mice at a dose of 50, 75, 100 and 200 μg/kg body weight for 10 days and modulation of the macrophage mediated innate immune responses was studied...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28985109/bioequivalence-of-a-liquid-formulation-of-alpha1-proteinase-inhibitor-compared-with-prolastin%C3%A2-c-lyophilized-alpha1-pi-in-alpha1-antitrypsin-deficiency
#19
Alan F Barker, Michael A Campos, Mark L Brantly, James M Stocks, Robert A Sandhaus, Douglas Lee, Kimberly Steinmann, Jiang Lin, Susan Sorrells
This study evaluated the bioequivalence, safety, and immunogenicity of a new liquid formulation of human plasma-derived alpha1-proteinase inhibitor, Liquid Alpha1-PI, compared with the Lyophilized Alpha1-PI formulation (Prolastin®-C), for augmentation therapy in patients with alpha1-antitrypsin deficiency (AATD). In this double-blind, randomized, 20-week crossover study, 32 subjects with AATD were randomized to receive 8 weekly infusions of 60 mg/kg of Liquid Alpha1-PI or Lyophilized Alpha1-PI. Serial blood samples were drawn for 7 days after the last dose followed by 8 weeks of the alternative treatment...
October 6, 2017: COPD
https://www.readbyqxmd.com/read/28957942/purification-and-characterization-of-a-new-highly-pure-double-virus-inactivated-von-willebrand-factor-concentrate
#20
Filippo Mori, Marcella Maddaluno, Claudio Farina
: Desmopressin-unresponsive von Willebrand disease patients are treated with substitutive therapy, with both pure von Willebrand factor (vWF) and factor VIII/vWF concentrates. We developed a new purification process, easily scalable to industrial level, to obtain a double virus inactivated highly pure vWF. VWF was purified starting from a waste fraction of already in use human plasma-derived factor VIII manufacturing procedure, using only one anionic-exchange chromatographic step. After chromatography, the product was dialyzed, lyophilized, and heat treated...
September 27, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
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