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Feras Abuzeyad, Leena Alqasem, Mudhaffar I Al Farras, Shaikha S Al Jawder, Ghada Al Qasim, Salah Alghanem
Following the publication of the original article [1], it was brought to our attention that author Leena Alqasem was erroneously included as Leena Alqusem.
March 5, 2018: International Journal of Emergency Medicine
Fares Alahdab, Wigdan Farah, Jehad Almasri, Patricia Barrionuevo, Feras Zaiem, Raed Benkhadra, Noor Asi, Mouaz Alsawas, Yifan Pang, Ahmed T Ahmed, Tamim Rajjo, Amrit Kanwar, Khalid Benkhadra, Zayd Razouki, M Hassan Murad, Zhen Wang
OBJECTIVE: To determine whether the early trials in chronic medical conditions demonstrate an effect size that is larger than that in subsequent trials. METHODS: We identified randomized controlled trials (RCTs) evaluating a drug or device in patients with chronic medical conditions through meta-analyses (MAs) published between January 1, 2007, and June 23, 2015, in the 10 general medical journals with highest impact factor. We estimated the prevalence of having the largest effect size or heterogeneity in the first 2 published trials...
February 6, 2018: Mayo Clinic Proceedings
Mark Nikolaj Wiese, Nadine Kawel-Boehm, Pablo Moreno de la Santa, Feras Al-Shahrabani, Melanie Toffel, Rachel Rosenthal, Juliane Schäfer, Michael Tamm, Jens Bremerich, Didier Lardinois
No abstract text is available yet for this article.
March 1, 2018: European Journal of Cardio-thoracic Surgery
Tamam El-Elimat, José Rivera-Chávez, Joanna E Burdette, Austin Czarnecki, Maram B Alhawarri, Mohammad Al-Gharaibeh, Feras Alali, Nicholas H Oberlies
Four new homoisoflavonoids, 7-O-methyl-8-demethoxy-3'-hydroxy-3,9-dihydropunctatin (4), 6-hydroxy-8-demethoxy-4'-O-methyl-3,9-dihydropunctatin (8), 7,4'-O-dimethyl-8-demethoxy-3,3'-dihydroxy-3,9-dihydropunctatin (13), and 7-O-methyl-3-hyroxy-3,9-dihydropunctatin (14) were identified from a chloroform extract of the bulbs of Bellevalia flexuosa, along with 13 known analogues. The structures were determined by analysis of HRMS and NMR data, while ECD spectroscopy enabled the assignment of the absolute configurations of the new compounds 4, 8, 13 and 16...
February 19, 2018: Fitoterapia
Md Sharafat Hossain, Duc Hau Huynh, Liming Jiang, Sharmin Rahman, Phuong Duc Nguyen, Feras Al-Dirini, Faruque Hossain, Je-Hyeong Bahk, Efstratios Skafidas
Recently, it has been demonstrated that graphene nano-ribbons (GNRs) exhibit superior thermoelectric performance compared to graphene sheets. However, the underlying mechanism behind this enhancement has not been systematically investigated and significant opportunity remains for further enhancement of the thermoelectric performance of GNRs by optimizing their charge carrier concentration. In this work, we modulate the carrier concentration of graphene-based nano-structures using a gate voltage and investigate the resulting carrier-concentration-dependent thermoelectric parameters using the Boltzmann transport equations...
February 22, 2018: Nanoscale
Jameela Abdulaziz Kari, Mohamed Ahmed Shalaby, Kholoud Sofyani, Ahmad Saleh Sanad, Albaraa Fuad Ossra, Rayan Smeer Halabi, Maha Hassan Aljuhani, Wael Mohammad Toffaha, Feras Aymen Moria, Samar Sabry, Hanan AbdelAziz Ahmed, Khalid Abdulaziz Alhasan, Sara Sharief, Osama Safdar
BACKGROUND: Acute kidney injury (AKI) is common in critically ill children with significant mortality and morbidity. Serum creatinine is an insensitive and late biomarker compared to newly proposed AKI biomarkers. METHODS: Prospective study in pediatric intensive care unit (PICU) over three months to compare between serum cystatin-C (s-Cys-C) and urinary neutrophil gelatinase-associated lipocalin (uNGAL) as AKI biomarkers at multiple time points with pediatric risk, injury, failure, loss, end-stage renal disease (pRIFLE) classification in diagnosing AKI...
February 20, 2018: World Journal of Pediatrics: WJP
Joya Hadchiti, Francois G Kamar, Jean Abi Ghosn, Mohamad Haidar, Ahmad Younes, Antoine Obeid, Marwan Haddad, Fadi Farhat, Feras Chehade
Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, commonly involves the lymph nodes but may secondarily involve the skin. Purely cutaneous disease without lymphatics or internal organ involvement occurs rarely. The present report detailed a rare case of 18F-fluoro-2-deoxyglucose positron emission-computed tomography (18FDG PET-CT) performed in a 33-year-old male soldier with a purely cutaneous form of RDD. Staging with 18FDG PET-CT was ordered prior to excisional biopsies of the aforedescribed masses and pathology reported RDD...
February 2018: Molecular and Clinical Oncology
Yoram A Weil, Feras Qawasmi, Meir Liebergall, Rami Mosheiff, Amal Khoury
BACKGROUND: Femoral neck fractures (FNF) are becoming increasingly common as population ages. Nondisplaced fractures are commonly treated by cancellous, parallel placed, partially threaded cannulated screws (PTS). This allows controlled fracture impaction. However, sliding implants can lead to femoral neck shortening (FNS) that has been shown to be correlated with reduced quality of life and impaired gait pattern. Recently, in our institution we have changed the fixation of FNF to fully threaded screws (FTS) with or without an additional partially threaded screw in order to minimize this phenomenon...
February 9, 2018: Archives of Orthopaedic and Trauma Surgery
Feras Abuzeyad, Leena Alqasem, Mudhaffar I Al Farras, Shaikha S Al Jawder, Ghada Al Qasim, Salah Alghanem
It has been more than a decade since emergency medicine became recognized as a specialty in the Kingdom of Bahrain. In the last fifteen years emergency medicine has widely established itself and developed rapidly in the Kingdom. The three main emergency departments are: Salmanyia Medical Complex (SMC), Royal Medical Services of Bahrain Defence Force (RMS-BDF) and King Hamad University Hospital (KHUH) are now fully equipped and operated by a majority of board certified emergency physicians.Standardized protocols, and the Central National Ambulance will be established in the near future, and the ambulances will offer both basic and advanced life support by trained nurses and paramedics...
February 8, 2018: International Journal of Emergency Medicine
Yasser Aljehani, Feras Almajid, Hind Alsaif
INTRODUCTION: Patients with primary spontaneous pneumothorax (PSP) rarely presented with radiological signs of tension pneumothorax on their presenting chest X-ray. Even though, those patients may not develop the hemodynamic instability that is seen in tension pneumothorax. The aim of this study is to elaborate whether the presence of radiological signs of tension pneumothorax in patients with PSP will affect their clinical presentation. METHODS: Retrospective study of all cases of PSP over a period from January 2007 to December 2014...
February 6, 2018: Emergency Radiology
Gilles Barone-Rochette, Feras Zoreka, Loïc Djaileb, Nicolas Piliero, Alex Calizzano, Jean Louis Quesada, Alexis Broisat, Laurent Riou, Jacques Machecourt, Daniel Fagret, Gerald Vanzetto, Catherine Ghezzi
BACKGROUND: The aim of this study was to determine the diagnostic accuracy of stress thallium-201/rest technetium-99m-sestamibi sequential dual-isotope high-speed myocardial perfusion imaging (DI-HS-MPI) against invasively determined fractional flow reserve (FFR). METHODS: Fifty-four consecutive patients prospectively underwent DI-HS-MPI before invasive coronary angiography. Perfusion was scored visually by summed stress score on a patient and coronary territory basis...
January 29, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Yudai Higuchi, Shogo Aoki, Hiroki Takenami, Naofumi Kamimura, Kenji Takahashi, Shojiro Hishiyama, Christopher S Lancefield, O Stephen Ojo, Yoshihiro Katayama, Nicholas J Westwood, Eiji Masai
Sphingobium sp. strain SYK-6 converts four stereoisomers of arylglycerol-β-guaiacyl ether into achiral β-hydroxypropiovanillone (HPV) via three stereospecific reaction steps. Here we determined the HPV catabolic pathway and characterized the HPV catabolic genes involved in the first two steps of the pathway. In SYK-6 cells, HPV was oxidized to vanilloyl acetic acid (VAA) via vanilloyl acetaldehyde (VAL). The resulting VAA was further converted into vanillate through the activation of VAA by coenzyme A. A syringyl-type HPV analog, β-hydroxypropiosyringone (HPS), was also catabolized via the same pathway...
January 26, 2018: Applied and Environmental Microbiology
Noura Alhashim, Mahmoud Aljurf, Mona Hassanein, Naeem Chaudhri, Shahrukh Hashmi, Ghada El-Gohary, Fahad Alsharif, Maamoun Alsermani, Muhned Alhumaid, Amal Al Beihany, Marwan Shaheen, Amr Hanbali, Feras Alfraih, Said Mohamed, Hazzaa Alzahrani, Tusneem Elhassan, Abdelmoneim Eldali, Walid Rasheed, Syed Ahmed, Fahad Almohareb, Riad El Fakih
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplant (allo-HCT) is challenging. Data on extramedullary relapse (EMR) after allo-HCT are limited. We analyzed 215 patients with AML who underwent allo-HCT in our institution between January 2005 and December 2015. We limited this retrospective review to patients who received a MA conditioning, were in complete remission (CR) at the time of transplant and who received a matched sibling transplant, all other patients were excluded to avoid heterogeneity...
January 25, 2018: Bone Marrow Transplantation
Toni Fera, Keith T Kanel, Meghan L Bolinger, Amber E Fink, Serah Iheasirim
PURPOSE: The creation of a clinical support role for a pharmacy technician within a primary care resource center is described. SUMMARY: In the Primary Care Resource Center (PCRC) Project, hospital-based care transition coordination hubs staffed by nurses and pharmacist teams were created in 6 independent community hospitals. At the largest site, patient volume for targeted diseases challenged the ability of the PCRC pharmacist to provide expected elements of care to targeted patients...
February 1, 2018: American Journal of Health-system Pharmacy: AJHP
Kamal Al Nasr, Feras Yousef, Ruba Jebril, Christopher Jones
To take advantage of recent advances in genomics and proteomics it is critical that the three-dimensional physical structure of biological macromolecules be determined. Cryo-Electron Microscopy (cryo-EM) is a promising and improving method for obtaining this data, however resolution is often not sufficient to directly determine the atomic scale structure. Despite this, information for secondary structure locations is detectable. De novo modeling is a computational approach to modeling these macromolecular structures based on cryo-EM derived data...
January 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Simon F Roy, Feras M Ghazawi, Bertrand Veilleux, Danielle Bouffard, Annie Bélisle
No abstract text is available yet for this article.
January 23, 2018: International Journal of Dermatology
Rena D Malik, Yuefeng Rose Wu, Alana L Christie, Feras Alhalabi, Philippe E Zimmern
No abstract text is available yet for this article.
January 10, 2018: Urology
Susanita Carvajal, Samantha N Fera, Abby L Jones, Thaisa A Baldo, Islam M Mosa, James F Rusling, Colleen E Krause
Rapidly fabricated, disposable sensor platforms hold tremendous promise for point-of-care detection. Here, we present an inexpensive (< $0.25) fully inkjet printed electrochemical sensor with integrated counter, reference, and working electrodes that is easily scalable for commercial fabrication. The electrochemical sensor platform featured an inkjet printed gold working 8-electrode array (WEA) and counter electrode (CE), along with an inkjet -printed silver electrode that was chlorinated with bleach to produce a Ag/AgCl quasi-reference electrode (RE)...
January 4, 2018: Biosensors & Bioelectronics
Feras Sharouf, Asfand Baig Mirza, Vazira Moosajee, Sarah Plummer, Imran M Bhatti, Malik Zaben
In neurosurgery, much emphasis has recently been placed on theatre cancellation and time utilization as a key hospital management performance indicator. We sought to evaluate our unit's theatre throughput efficiency and identify the causes of elective surgery cancellations. We retrospectively audited all scheduled elective neurosurgical procedures over a period of nine months. Mean theatre utilization time was 47.0%. The common causes of cancellations were lack of theatre time (32%), non-availability of beds in recovery room (18...
April 2017: Journal of Perioperative Practice
Mohamad Shebley, Punam Sandhu, Arian Emami Riedmaier, Masoud Jamei, Rangaraj Narayanan, Aarti Patel, Sheila Annie Peters, Venkatesh Pilla Reddy, Ming Zheng, Loeckie de Zwart, Maud Beneton, Francois Bouzom, Jun Chen, Yuan Chen, Yumi Cleary, Christiane Collins, Gemma L Dickinson, Nassim Djebli, Heidi J Einolf, Iain Gardner, Felix Huth, Faraz Kazmi, Feras Khalil, Jing Lin, Aleksandrs Odinecs, Chirag Patel, Haojing Rong, Edgar Schuck, Pradeep Sharma, Shu-Pei Wu, Yang Xu, Shinji Yamazaki, Kenta Yoshida, Malcolm Rowland
This work provides a perspective on the qualification and verification of physiologically based pharmacokinetic (PBPK) platforms/models intended for regulatory submission based on the collective experience of the Simcyp Consortium members. Examples of regulatory submission of PBPK analyses across various intended applications are presented and discussed. European Medicines Agency (EMA) and US Food and Drug Administration (FDA) recent draft guidelines regarding PBPK analyses and reporting are encouraging, and to advance the use and acceptability of PBPK analyses, more clarity and flexibility are warranted...
January 9, 2018: Clinical Pharmacology and Therapeutics
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