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Feras Q Alali, Tamam El-Elimat, Lila Khalid, Reema Hudaib, Tuqa Saleh Al-Shehabi, Ali H Eid
Cardiovascular disease (CVD) is the leading cause of global mortality with a substantial economic impact. The annual deaths are expected to increase in the next decade. An array of dietary supplements is being used by people worldwide to ameliorate cardiovascular risk factors. Garlic (Allium sativum L.), a top-selling herbal dietary supplement, is renowned for its wide range beneficial effects, particularly in the treatment and prevention of CVD. This review aims to present a thorough discussion of the available evidence-based data which support the use of garlic in the treatment or prevention of cardiovascular diseases, including atherosclerosis, hypertension, and hyperlipidemia...
October 10, 2016: Current Pharmaceutical Design
Feras M Ghazawi, Giulia Vinco, Mathieu Walker
Caseous calcification of the mitral annulus (CCMA) is a rare variant of mitral annulus calcification which presents as a semilunar echodense mass with smooth borders and central areas of echolucency. It is an under-recognized benign entity and can be misdiagnosed for a number of pathologies including tumors, abscesses and thrombi. We present a representative CCMA case and highlight its typical appearance on magnetic resonance imaging.
October 14, 2016: International Journal of Cardiovascular Imaging
Mengyi Liu, Shiguang Shan, Ruiping Wang, Xilin Chen
Facial expression is a temporally dynamic event which can be decomposed into a set of muscle motions occurring in different facial regions over various time intervals. For dynamic expression recognition, two key issues, temporal alignment and semantics-aware dynamic representation, must be taken into account. In this paper, we attempt to solve both problems via manifold modeling of videos based on a novel midlevel representation, i.e. expressionlet. Specifically, our method contains three key stages: 1) each expression video clip is characterized as a spatial-temporal manifold (STM) formed by dense low-level features; 2) a Universal Manifold Model (UMM) is learned over all low-level features and represented as a set of local modes to statistically unify all the STMs...
October 5, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Mohammad-Ali Jenabian, Cecilia T Costiniuk, Vikram Mehraj, Feras M Ghazawi, Rémi Fromentin, Joëlle Brousseau, Pierre Brassard, Maud Bélanger, Petronela Ancuta, Reina Bendayan, Nicolas Chomont, Jean-Pierre Routy
OBJECTIVE: HIV persistence in long-lived infected cells and in anatomical sanctuary sites are major hurdles to HIV eradication. Testicular tissue may represent a significant viral sanctuary site as it constitutes an immunologically-privileged compartment. We assessed immuno-tolerance properties of the testicular tissue in individuals receiving suppressive ART. DESIGN AND METHODS: Testicular tissue and matched blood samples were collected from 6 virally suppressed adults and 10 HIV-uninfected controls prior to gender reassignment surgery...
September 24, 2016: AIDS
Soha Al-Amoudi, Rozaimi Razali, Magbubah Essack, Mohammad Shoaib Amini, Salim Bougouffa, John A C Archer, Feras F Lafi, Vladimir B Bajic
Since the composition of soil directs the diversity of the contained microbiome and its potential to produce bioactive compounds, many studies has been focused on sediment types with unique features characteristic of extreme environments. However, not much is known about the potential of microbiomes that inhabit the highly saline and hot Red Sea lagoons. This case study explores mangrove mud and the microbial mat of sediments collected from the Rabigh harbor lagoon and Al Kharrar lagoon for antimicrobial bioprospecting...
December 15, 2016: Gene
Soha Al-Amoudi, Magbubah Essack, Marta F Simões, Salim Bougouffa, Irina Soloviev, John A C Archer, Feras F Lafi, Vladimir B Bajic
Microorganisms that inhabit unchartered unique soil such as in the highly saline and hot Red Sea lagoons on the Saudi Arabian coastline, represent untapped sources of potentially new bioactive compounds. In this study, a culture-dependent approach was applied to three types of sediments: mangrove mud (MN), microbial mat (MM), and barren soil (BS), collected from Rabigh harbor lagoon (RHL) and Al-Kharrar lagoon (AKL). The isolated bacteria were evaluated for their potential to produce bioactive compounds. The phylogenetic characterization of 251 bacterial isolates based on the 16S rRNA gene sequencing, supported their assignment to five different phyla: Proteobacteria, Firmicutes, Actinobacteria, Bacteroidetes, and Planctomycetes...
September 10, 2016: Marine Drugs
Riad Awad, Eyad Mallah, Bayan Al Khawaja, Wael Abu Dayyih, Feras El-Hajji, Khalid Z Matalka, Tawfiq Arafat
OBJECTIVES: Food or drinks may significantly alter the pharmacokinetics and pharmacodynamics of drugs which may lead to adverse events. A drug such as metformin is widely used to regulate plasma glucose level and pomegranate and licorice have been identified to help in type-2 diabetes management. However, the interactions of the latter on metformin pharmacokinetics were not studied. Therefore, we aimed here to study the impact of pomegranate and licorice on metformin pharmacokinetics in rats...
July 12, 2016: Neuro Endocrinology Letters
Werner Mohrig, Ellen Kauschke
In the Nearctic region the genus Scatopsciara includes 37 species. Herein these species are diagnosed, keyed and distribution data provided. Twenty six species are known exclusively from the Nearctic region. Eleven species have a Holarctic distribution. Nineteen species are described as new for science. These are: Scatopsciara abedabunae sp. n. (USA, Canada), Sc. adsilae sp. n. (USA), Sc. alawae sp. n. (USA), Sc. awanatae sp. n. (USA), Sc. awinitae sp. n. (USA, Canada), Sc. catoriae sp. n. (USA), Sc. chenoae sp...
2016: Zootaxa
C Grozavu, A Fera, M Iliaş, D Pantile
INTRODUCTION: Bronchogenic cysts, commonly located in the mediastinum or lung parenchyma, arise from abnormal budding of the tracheobronchial tree. Since an unknown percentage of asymptomatic adult patients with bronchogenic cysts remain undiagnosed, the true natural history ofthese cysts in adults is uncertain and the available series reflect a significant selection bias in favor of the symptomatic individual. CASE REPORT: We present the case of a 42-year-old female who presented with adull central chest pain, which gradually worsened overseveral weeks...
July 2016: Chirurgia
Feras Ali Mustafa
PURPOSE: The closure of a neighboring psychiatric intensive care unit (PICU) provided an opportunity to evaluate the number of PICU beds required per head of population and to explore how referrals to the PICU are prioritized. DESIGN AND METHODS: Data were collected and analyzed for admissions to our PICU in the year before and the year after the closure of the other unit. FINDINGS: Admissions increased (in year 2) by 42%, although there was no significant increase in the use of restrictive nursing interventions...
September 6, 2016: Perspectives in Psychiatric Care
Scott Sugden, Feras Ghazawi, Paul MacPherson
HIV-1 Tat protein down regulates expression of the IL-7 receptor alpha-chain (CD127) from the surface of CD8 T cells resulting in impaired T cell proliferation and cytolytic capacity. We have previously shown that soluble Tat protein is taken up by CD8 T cells and interacts with the cytoplasmic tail of CD127 to induce receptor degradation. The N-terminal domain of Tat interacts with CD127 while the basic domain directs CD127 to the proteasome. We have also shown that upon IL-7 binding to its receptor, CD127 is phosphorylated resulting in CIS-mediated proteasomal degradation...
November 2016: Virology
Juzer A Kakal, Feras M Ghazawi, Elliott M Faller, Scott M Sugden, Parmvir Parmar, Paul A MacPherson
Interleukin-7 is essential for the development and maintenance of T cells, and the expression of the IL-7 receptor is tightly regulated at every stage of the T cell's lifespan. In mature CD8 T cells, IL-7 plays important roles in cell survival, peripheral homeostasis, and cytolytic function. The IL-7 receptor alpha-chain (CD127) is expressed at high levels on naïve and memory cells, but it is rapidly downregulated upon IL-7 stimulation. In this study, we illustrate the dynamicity of the CD127 promoter and show that it possesses positive as well as negative regulatory sites involved in upregulating and downregulating CD127 expression, respectively...
August 19, 2016: Immunogenetics
Mouaffaa Tello, Feras Zaiem, Mary Catherine Tolcher, Mohammad Hassan Murad
Acting on results that are not statistically significant is challenging for clinicians. Such results are often interpreted as evidence of lack of association or as useless evidence. We provide a framework for interpreting and applying non-significant results at the point of care using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
October 2016: Evidence-based Medicine
Inkyu Sa, Zongyuan Ge, Feras Dayoub, Ben Upcroft, Tristan Perez, Chris McCool
This paper presents a novel approach to fruit detection using deep convolutional neural networks. The aim is to build an accurate, fast and reliable fruit detection system, which is a vital element of an autonomous agricultural robotic platform; it is a key element for fruit yield estimation and automated harvesting. Recent work in deep neural networks has led to the development of a state-of-the-art object detector termed Faster Region-based CNN (Faster R-CNN). We adapt this model, through transfer learning, for the task of fruit detection using imagery obtained from two modalities: colour (RGB) and Near-Infrared (NIR)...
2016: Sensors
Feras F Lafi, Ameerah Bokhari, Intikhab Alam, Vladimir B Bajic, Heribert Hirt, Maged M Saad
We isolated the plant endophytic bacterium Cupriavidus gilardii strain JZ4 from the roots of the desert plant Tribulus terrestris, collected from the Jizan region, Saudi Arabia. We report here the draft genome sequence of JZ4, together with several enzymes related to plant growth-promoting activity, environmental adaption, and antifungal activity.
2016: Genome Announcements
Feras Ali Mustafa
No abstract text is available yet for this article.
October 1, 2016: JAMA Psychiatry
Feras M Ghazawi, Elliott M Faller, Parmvir Parmar, Abdulkareem El-Salfiti, Paul A MacPherson
Given the essential role interleukin (IL)-7 plays in T-cell survival, homeostasis and function, it is no surprise expression of the IL-7 receptor alpha-chain (CD127) is tightly regulated. We have previously shown IL-7 binding to its receptor on the surface of CD8 T cells leads to both suppression of CD127 gene transcription and loss of existing CD127 protein from the cell membrane. Indeed upon binding IL-7, CD127 is rapidly internalized into early endosomes where phosphorylation by JAK targets the receptor for degradation...
August 2016: Cellular Immunology
Fares Alahdab, Feras Zaiem, Zhen Wang, M Hassan Murad
No abstract text is available yet for this article.
August 2016: Evidence-based Medicine
Najah Alhashimi, Feras H Abed Al Jawad, Muneera Al Sheeb, Buthaina Al Emadi, Jamal Al-Abdulla, Hanan Al Yafei
OBJECTIVE: There is no data specific to the Qatari population on the prevalence and distribution of hyperdontia. The aim of this study was to investigate the prevalence and distribution of hyperdontia in the permanent teeth among a group of Qatari sample and to compare the present results with findings from other populations. MATERIALS AND METHODS: Records of 1269 Qatari patients (674 females; mean age 11.8 ± 2.3 and 595 males; mean age 11.4 ± 2.2 years) which included panoramic radiographs were examined to identify hyperdontia in the permanent dentition...
July 2016: European Journal of Dentistry
Camilo Chaves, Feras Alshomer, Robert G Palgrave, Deepak M Kalaskar
This study present amino functionalization of biocompatible polymer polyhedral oligomeric silsequioxane-poly(carbonate-urea) urethane (POSS-PCU) using plasma polymerization process to induce osteogenic differentiation of adipose derived stem cells (ADSCs). Optimization of plasma polymerization process was carried out keeping cell culture application in mind. Thus, samples were rigorously tested for retention of amino groups under both dry and wet conditions. Physio-chemical characterization was carried out using ninhydrin test, X-ray photon spectroscopy, scanning electron microscopy, and static water contact analysis...
July 27, 2016: ACS Applied Materials & Interfaces
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