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https://www.readbyqxmd.com/read/28298420/staged-induction-of-hiv-1-glycan-dependent-broadly-neutralizing-antibodies
#1
Mattia Bonsignori, Edward F Kreider, Daniela Fera, R Ryan Meyerhoff, Todd Bradley, Kevin Wiehe, S Munir Alam, Baptiste Aussedat, William E Walkowicz, Kwan-Ki Hwang, Kevin O Saunders, Ruijun Zhang, Morgan A Gladden, Anthony Monroe, Amit Kumar, Shi-Mao Xia, Melissa Cooper, Mark K Louder, Krisha McKee, Robert T Bailer, Brendan W Pier, Claudia A Jette, Garnett Kelsoe, Wilton B Williams, Lynn Morris, John Kappes, Kshitij Wagh, Gift Kamanga, Myron S Cohen, Peter T Hraber, David C Montefiori, Ashley Trama, Hua-Xin Liao, Thomas B Kepler, M Anthony Moody, Feng Gao, Samuel J Danishefsky, John R Mascola, George M Shaw, Beatrice H Hahn, Stephen C Harrison, Bette T Korber, Barton F Haynes
A preventive HIV-1 vaccine should induce HIV-1-specific broadly neutralizing antibodies (bnAbs). However, bnAbs generally require high levels of somatic hypermutation (SHM) to acquire breadth, and current vaccine strategies have not been successful in inducing bnAbs. Because bnAbs directed against a glycosylated site adjacent to the third variable loop (V3) of the HIV-1 envelope protein require limited SHM, the V3-glycan epitope is an attractive vaccine target. By studying the cooperation among multiple V3-glycan B cell lineages and their coevolution with autologous virus throughout 5 years of infection, we identify key events in the ontogeny of a V3-glycan bnAb...
March 15, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28289969/influence-of-testing-parameters-on-in-vitro-tramadol-release-from-poloxamer-thermogels-using-the-immersion-cell-method
#2
Lorina Bisharat, Diego R Perinelli, Alberto Berardi, Giulia Bonacucina, Serena Logrippo, Feras W Darwish Elhajji, Marco Cespi, Giovanni F Palmieri
The immersion cell is an in vitro performance test of drug release from semisolids. Several studies made use of immersion cells to investigate drug release from thermosensitive Poloxamer-based gels; however, specifications on the parameter setting are not yet available. Therefore, the aim of this study was to evaluate the influence of testing parameters on tramadol (a model drug) release, release rate, and dissolution efficiency (DE) from Poloxamer gels, using immersion cells. The thermosensitive gelling formulation showed batch-to-batch uniformity of gelling behavior, drug content, and drug release...
March 13, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28267602/management-of-urinary-incontinence-following-sub-urethral-sling-removal
#3
Nirmish Singla, Himanshu Aggarwal, Jeannine Foster, Feras Alhalabi, Gary E Lemack, Philippe E Zimmern
PURPOSE: To evaluate urinary incontinence outcomes following synthetic sub-urethral sling removal (SSR) in women. METHODS: We reviewed a prospectively-maintained database of 360 consecutive women who underwent transvaginal SSR from 2005-2015. We excluded patients with neurogenic bladder, non-synthetic or multiple slings, prior mesh for prolapse, concomitant surgery during sling excision, urethral erosion or fistula, post-operative retention, or <6 months follow-up...
March 3, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28262085/the-jordanian-primary-healthcare-practitioner-in-cancer-control
#4
Nour A Obeidat, Feras I Hawari, Malek A Habashneh, Rawan A Shihab
Aim To measure the knowledge, perceptions, and practices of Jordanian primary healthcare practitioners (PHCPs) (physicians, nurses, midwives, and nurse aids) employed in Jordanian Ministry of Health (MoH) primary health clinics with respect to counseling on cancer (cancer screening, the signs and symptoms of cancer, and referral for specialized care). BACKGROUND: Integration of oncology services within primary care is a means of enhancing cancer early detection, and requires involvement of skilled...
March 6, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28254978/draft-genome-sequence-of-the-plant-growth-promoting-rhizobacterium-acinetobacter-radioresistens-strain-sa188-isolated-from-the-desert-plant-indigofera-argentea
#5
Feras F Lafi, Intikhab Alam, Ton Bisseling, Rene Geurts, Vladimir B Bajic, Heribert Hirt, Maged M Saad
Acinetobacter radioresistens strain SA188 is a plant endophytic bacterium, isolated from root nodules of the desert plants Indigofera spp., collected in Jizan, Saudi Arabia. Here, we report the 3.2-Mb draft genome sequence of strain SA188, highlighting characteristic pathways for plant growth-promoting activity and environmental adaptation.
March 2, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28254977/draft-genome-sequence-of-ochrobactrum-intermedium-strain-sa148-a-plant-growth-promoting-desert-rhizobacterium
#6
Feras F Lafi, Intikhab Alam, Rene Geurts, Ton Bisseling, Vladimir B Bajic, Heribert Hirt, Maged M Saad
Ochrobactrum intermedium strain SA148 is a plant growth-promoting bacterium isolated from sandy soil in the Jizan area of Saudi Arabia. Here, we report the 4.9-Mb draft genome sequence of this strain, highlighting different pathways characteristic of plant growth promotion activity and environmental adaptation of SA148.
March 2, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28209831/draft-genome-sequence-of-enterobacter-sp-sa187-an-endophytic-bacterium-isolated-from-the-desert-plant-indigofera-argentea
#7
Feras F Lafi, Intikhab Alam, Rene Geurts, Ton Bisseling, Vladimir B Bajic, Heribert Hirt, Maged M Saad
Enterobacter sp. Sa187 is a plant endophytic bacterium, isolated from root nodules of the desert plant Indigofera argentea, collected from the Jizan region of Saudi Arabia. Here, we report the genome sequence of Sa187, highlighting several genes involved in plant growth-promoting activity and environmental adaption.
February 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28188759/bladder-prolapse-configuration-on-baseline-standing-cystogram-can-predict-anterior-vaginal-wall-suspension-procedure-outcomes
#8
Yuefeng Rose Wu, Alana L Christie, Rebecca S Lavelle, Feras Alhalabi, Gaurav Khatri, Philippe E Zimmern
OBJECTIVE: To evaluate whether bladder prolapse shape on lateral voiding cystourethrogram (VCUG) is an accurate predictor of anterior vaginal wall suspension (AVWS) procedure outcomes. METHODS: Following an institutional review board approval, preoperative lateral standing VCUG views from a prospectively maintained database of women who underwent AVWS for stage ≥2 cystocele were reviewed retrospectively by 3 reviewers. Patients with no retrievable preoperative VCUG imaging were excluded...
February 7, 2017: Urology
https://www.readbyqxmd.com/read/28179408/time-resolved-global-and-chromatin-proteomics-during-herpes-simplex-virus-hsv-1-infection
#9
Katarzyna Kulej, Daphne C Avgousti, Simone Sidoli, Christin Herrmann, Ashley N Della Fera, Eui Tae Kim, Benjamin A Garcia, Matthew D Weitzman
Herpes simplex virus (HSV-1) lytic infection results in global changes to the host cell proteome and the proteins associated with host chromatin. We present a system level characterization of proteome dynamics during infection by performing a multi-dimensional analysis during HSV-1 lytic infection of human foreskin fibroblast (HFF) cells. Our study includes identification and quantification of the host and viral proteomes, phosphoproteomes, chromatin bound proteomes and post-translational modifications (PTMs) on cellular histones during infection...
February 8, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28174010/a-case-of-t-cell-lymphoproliferative-disorder-associated-with-hypereosinophilia-with-excellent-response-to-mycophenolate-mofetil
#10
Amr Hanbali, Marwan Shaheen, Feras Alfraih, Wafa Al-Otaibi, Riad El Fakih, Tarek Owaidah, Syed Ahmed
Hypereosinophilic syndrome (HES) is a group of rare blood disorders characterized by a persistent elevation of blood eosinophil count ⩾1.5×10(9)/L and clinical manifestations attributable to eosinophilia or tissue hypereosinophilia. Lymphocytic variant of HES (HES-L) is a known subtype according to World Health Organization classification. It is well documented in the literature that patients with HES-L are predisposed to develop T-cell lymphoma. We report a case of T-cell lymphoproliferation associated with hypereosinophilia, which has been successfully treated with mycophenolate mofetil, with resolution of skin lesions and normalization of eosinophil count and immunoglobulin E level...
February 1, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28164253/heart-failure-in-the-elderly-ten-peculiar-management-considerations
#11
Feras Bader, Bassam Atallah, Lisa F Brennan, Rola H Rimawi, Mohammed E Khalil
Chronic heart failure (HF) is a disease with significantly higher prevalence in the elderly or patients older than 65 years old. Typically, older patients have more risk factors for HF, more comorbidities, and are more likely to have recurrent admissions for acute decompensations. With HF burden on health care systems primarily related to hospital and nursing home costs, it is critical that elderly patients are approached with a clear understanding of certain unique clinical, laboratory, imaging, and pharmacokinetic differences that can alter their management and outcomes...
February 6, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28126944/draft-genome-sequence-of-plant-growth-promoting-micrococcus-luteus-strain-k39-isolated-from-cyperus-conglomeratus-in-saudi-arabia
#12
Feras F Lafi, Juan S Ramirez-Prado, Intikhab Alam, Vladimir B Bajic, Heribert Hirt, Maged M Saad
Micrococcus luteus strain K39 is an endophyte bacterium isolated from roots of the desert plant Cyperus conglomeratus collected from the Red Sea shore, Thuwal, Saudi Arabia. The draft genome sequence of strain K39 revealed a number of enzymes involved in salinity and oxidative stress tolerance or having herbicide-resistance activity.
January 26, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28126378/the-role-of-letters-of-recommendation-in-the-selection-process-of-surgical-residents-in-canada-a-national-survey-of-program-directors
#13
Yousef Marwan, Feras Waly, Nizar Algarni, Abdullah Addar, Neil Saran, Linda Snell
OBJECTIVE: Letters of recommendation (LOR) provide valuable information that help in selecting new residents. In this study, we aim to investigate the perceptions of surgical residency program directors (PDs) in Canada on the elements that can affect the strength and value of LOR. DESIGN: Cross-sectional; survey. SETTING: A national survey was conducted using an online questionnaire consisting of 2 main sections to collect data from PDs from all surgical subspecialties...
January 23, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28115252/micropatterning-of-nanocomposite-polymer-scaffolds-using-sacrificial-phosphate-glass-fibers-for-tendon-tissue-engineering-applications
#14
Feras Alshomer, Camilo Chaves, Tiziano Serra, Ifty Ahmed, Deepak M Kalaskar
This study presents a simple and reproducible method of micropatterning the novel nanocomposite polymer (POSS-PCU) using a sacrificial phosphate glass fiber template for tendon tissue engineering applications. The diameters of the patterned scaffolds produced were dependent on the diameter of the glass fibers (15 μm) used. Scaffolds were tested for their physical properties and reproducibility using various microscopy techniques. For the first time, we show that POSS-PCU supports growth of human tenocytes cells...
January 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28113507/learning-expressionlets-via-universal-manifold-model-for-dynamic-facial-expression-recognition
#15
Mengyi Liu, Shiguang Shan, Ruiping Wang, Xilin Chen
Facial expression is a temporally dynamic event which can be decomposed into a set of muscle motions occurring in different facial regions over various time intervals. For dynamic expression recognition, two key issues, temporal alignment and semantics-aware dynamic representation, must be taken into account. In this paper, we attempt to solve both problems via manifold modeling of videos based on a novel midlevel representation, i.e. expressionlet. Specifically, our method contains three key stages: 1) each expression video clip is characterized as a spatial-temporal manifold (STM) formed by dense low-level features; 2) a Universal Manifold Model (UMM) is learned over all low-level features and represented as a set of local modes to statistically unify all the STMs...
October 5, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28113267/selective-transfer-machine-for-personalized-facial-expression-analysis
#16
Wen-Sheng Chu, Fernando de la Torre, Jeffrey Cohn
Automatic facial action unit (AU) and expression detection from videos is a long-standing problem. The problem is challenging in part because classifiers must generalize to previously unknown subjects that differ markedly in behavior and facial morphology (e.g., heavy versus delicate brows, smooth versus deeply etched wrinkles) from those on which the classifiers are trained. While some progress has been achieved through improvements in choices of features and classifiers, the challenge occasioned by individual differences among people remains...
March 28, 2016: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28101814/arbutus-andrachne-l-reverses-sleep-deprivation-induced-memory-impairments-in-rats
#17
Karem H Alzoubi, Bayan S Malkawi, Omar F Khabour, Tamam El-Elimat, Feras Q Alali
Sleep deprivation (SD) is associated with cognitive deficits. It was found to affect the hippocampus region of the brain by impairing memory formation. This impairment is suggested to be caused by elevation in oxidative stress in the body, including the brain during SD. It was hypothesized that the methanolic extract of the fruits of Arbutus andrachne L. (Ericaceae) will prevent chronic SD-induced impairment of hippocampal memory via its antioxidative properties. The methanolic extract of the fruits of A. andrachne was evaluated for its beneficial properties to reverse SD-induced cognitive impairment in rats...
January 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28101321/switching-away-from-pipotiazine-palmitate-a-naturalistic-study
#18
Feras Ali Mustafa
BACKGROUND: In March 2015, pipotiazine palmitate depot antipsychotic was globally withdrawn due to the shortage of its active ingredient. Thus, all patients receiving this medication had to be switched to an alternative antipsychotic drug. In this study we set to evaluate the process of switching away from pipotiazine palmitate within our clinical service, and its impact on hospitalization. METHODS: Demographic and clinical data on patients who were receiving pipotiazine palmitate in Northamptonshire at the time of its withdrawal were anonymously extracted from their electronic records and analyzed using descriptive statistics...
January 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28095041/oral-versus-transdermal-estrogen-in-turner-syndrome-a-systematic-review-and-meta-analysis
#19
Feras Zaiem, Fares Alahdab, Alaa Al Nofal, Mohammad Hassan Murad, Asma Javed
OBJECTIVE: To conduct a systematic review and meta-analysis comparing transdermal estrogens (TDE) versus oral estrogens (OE) in Turner syndrome (TS). METHOD: Randomized trials and observational comparative studies with a minimal follow up of 6 months for skeletal and metabolic outcomes and serum hormone changes. Outcomes were pooled with a random effects model and were reported as mean difference between OE and TDE groups and 95% confidence interval (CI). RESULT: Of 845 candidate references, 4 studies were included...
January 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28090729/notes-on-the-use-of-randomised-controlled-trials-to-evaluate-complex-interventions-community-treatment-orders-as-an-illustrative-case
#20
Feras Ali Mustafa
Over the past seven decades, randomised controlled trials (RCTs) have revolutionised clinical research and achieved a gold standard status. However, extending their use to evaluate complex interventions is problematic. In this paper we will demonstrate that complex intervention RCTs violate the necessary premises that govern the RCTs logic and underpin their rigour. The lack of blinding, heterogeneity of participants, as well as poor treatment standardisation and difficulty of controlling for confounders, which characterise complex intervention RCTs, can potentially be profoundly detrimental to their integrity...
February 2017: Journal of Evaluation in Clinical Practice
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