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https://www.readbyqxmd.com/read/29331567/author-reply
#1
Rena D Malik, Yuefeng Rose Wu, Alana L Christie, Feras Alhalabi, Philippe E Zimmern
No abstract text is available yet for this article.
January 10, 2018: Urology
https://www.readbyqxmd.com/read/29331430/disposable-inkjet-printed-electrochemical-platform-for-detection-of-clinically-relevant-her-2-breast-cancer-biomarker
#2
Susanita Carvajal, Samantha N Fera, Abby L Jones, Thaisa A Baldo, Islam M Mosa, James F Rusling, Colleen E Krause
Rapidly fabricated, disposable sensor platforms hold tremendous promise for point-of-care detection. Here, we present an inexpensive (< $0.25) fully inkjet printed electrochemical sensor with integrated counter, reference, and working electrodes that is easily scalable for commercial fabrication. The electrochemical sensor platform featured an inkjet printed gold working 8-electrode array (WEA) and counter electrode (CE), along with an inkjet -printed silver electrode that was chlorinated with bleach to produce a Ag/AgCl quasi-reference electrode (RE)...
January 4, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29328748/analysis-of-neuro-theatre-utilisation-and-reasons-for-cancellation-to-improve-efficiency-and-productivity
#3
Feras Sharouf, Asfand Baig Mirza, Vazira Moosajee, Sarah Plummer, Imran M Bhatti, Malik Zaben
In neurosurgery, much emphasis has recently been placed on theatre cancellation and time utilization as a key hospital management performance indicator. We sought to evaluate our unit's theatre throughput efficiency and identify the causes of elective surgery cancellations. We retrospectively audited all scheduled elective neurosurgical procedures over a period of nine months. Mean theatre utilization time was 47.0%. The common causes of cancellations were lack of theatre time (32%), non-availability of beds in recovery room (18...
April 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29315504/physiologically-based-pharmacokinetic-model-qualification-and-reporting-procedures-for-regulatory-submissions-a-consortium-perspective
#4
REVIEW
Mohamad Shebley, Punam Sandhu, Arian Emami Riedmaier, Masoud Jamei, Rangaraj Narayanan, Aarti Patel, Sheila Annie Peters, Venkatesh Pilla Reddy, Ming Zheng, Loeckie de Zwart, Maud Beneton, Francois Bouzom, Jun Chen, Yuan Chen, Yumi Cleary, Christiane Collins, Gemma L Dickinson, Nassim Djebli, Heidi J Einolf, Iain Gardner, Felix Huth, Faraz Kazmi, Feras Khalil, Jing Lin, Aleksandrs Odinecs, Chirag Patel, Haojing Rong, Edgar Schuck, Pradeep Sharma, Shu-Pei Wu, Yang Xu, Shinji Yamazaki, Kenta Yoshida, Malcolm Rowland
No abstract text is available yet for this article.
January 9, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29303758/response-of-soft-tissue-to-different-abutment-materials-with-different-surface-topographies-a-review-of-the-literature
#5
Feras Al Rezk, Georgia Trimpou, Hans-Christoph Lauer, Paul Weigl, Nadine Krockow
Soft tissue integration in the transmucosal zone of dental abutments supports the peri-implant tissues, improves esthetics, ensures soft tissue seal against microorganisms, and preserves crestal bone level. The aim of this literature review was to define the most favorable surface topography and macrodesign of the transmucosal zone of abutments to achieve optimal soft tissue seal. An electronic search of the PubMed/MEDLINE database was performed, seeking relevant English-language articles published between January 1, 2003, and October 11, 2014...
January 2018: General Dentistry
https://www.readbyqxmd.com/read/29275031/the-diagnostic-accuracy-of-fractional-exhaled-nitric-oxide-testing-in-asthma-a-systematic-review-and-meta-analyses
#6
Zhen Wang, Paolo T Pianosi, Karina A Keogh, Feras Zaiem, Mouaz Alsawas, Fares Alahdab, Jehad Almasri, Khaled Mohammed, Laura Larrea-Mantilla, Wigdan Farah, Lubna Daraz, Patricia Barrionuevo, Allison S Morrow, Larry J Prokop, Mohammad Hassan Murad
OBJECTIVE: To evaluate the diagnostic accuracy of fractional exhaled nitric oxide (FeNO) measurement in individuals with suspected asthma. METHODS: We searched MEDLINE, EMBASE, PsycINFO, Cochrane databases, and SciVerse Scopus from the databases' inception through April 4, 2017, for studies that enrolled patients aged 5 years and older with suspected asthma and evaluated FeNO diagnostic accuracy. Independent reviewers selected studies and extracted data. We used the symmetric hierarchical summary receiver operating characteristic models to estimate test performance...
December 16, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29242249/acidosis-and-deafness-in-patients-with-recessive-mutations-in-foxi1
#7
Sven Enerbäck, Daniel Nilsson, Noel Edwards, Mikael Heglind, Sumaya Alkanderi, Emma Ashton, Asma Deeb, Feras E B Kokash, Abdulrahim R A Bakhsh, William Van't Hoff, Stephen B Walsh, Felice D'Arco, Arezoo Daryadel, Soline Bourgeois, Carsten A Wagner, Robert Kleta, Detlef Bockenhauer, John A Sayer
Maintenance of the composition of inner ear fluid and regulation of electrolytes and acid-base homeostasis in the collecting duct system of the kidney require an overlapping set of membrane transport proteins regulated by the forkhead transcription factor FOXI1. In two unrelated consanguineous families, we identified three patients with novel homozygous missense mutations in FOXI1 (p.L146F and p.R213P) predicted to affect the highly conserved DNA binding domain. Patients presented with early-onset sensorineural deafness and distal renal tubular acidosis...
December 14, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29241349/distribution-and-clustering-of-cutaneous-t-cell-lymphoma-ctcl-cases-in-canada-during-1992-to-2010
#8
Feras M Ghazawi, Elena Netchiporouk, Elham Rahme, Matthew Tsang, Linda Moreau, Steven Glassman, Nathalie Provost, Martin Gilbert, Sara-Elizabeth Jean, Osama Roshdy, Kevin Pehr, Denis Sasseville, Ivan V Litvinov
BACKGROUND: Clustering of patients with cutaneous T-cell lymphoma (CTCL) was reported in several jurisdictions around the world. This rare cancer is known to affect spouses and in some cases multiple members of the same family. These combined results suggest the existence of external disease triggers/promoters. We recently conducted the first comprehensive analysis of CTCL incidence and mortality in Canada, which revealed case clustering in several regions. OBJECTIVES: To extend our previous analysis on CTCL incidence across Canada and to provide all the collected data on CTCL patient incidence in Canada during the period of 1992 to 2010...
December 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29240586/insights-into-the-pathophysiology-of-hypertrophic-scars-and-keloids-how-do-they-differ
#9
Feras M Ghazawi, Ramin Zargham, Mirko S Gilardino, Denis Sasseville, Fatemeh Jafarian
GENERAL PURPOSE: To provide information about the clinical presentation of hypertrophic scars and keloids based on their varied structural components. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After completing this continuing education activity, you should be able to: ABSTRACT: Hypertrophic scars and keloids are firm, raised, erythematous plaques or nodules that manifest when the cicatrix fails to properly heal...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29234260/can-anterior-prostatic-fat-harbor-prostate-cancer-metastasis-a-prospective-cohort-study
#10
Mohannad Hosny, Bhavan Rai, Feras Aljaafari, Samita Agarwal, Thomas McNicholas, Gregory Boustead, Thimothy Lane, James Adshead, Nikhil Vasdev
Objectives: Traditionally anterior prostatic fat (APF) hasn't been included in pelvic lymph node (LN) dissection templates following radical prostatectomy. In this study we evaluate the incidence of lymphoid tissue in the APF and the incidence of LN metastasis in APF in patients who have undergone robotic-assisted laparoscopic radical prostatectomy (RALP). Methods: A prospective database of RALP has been maintained between January 2010 and September 2015. APF is routinely excised and sent separately for histopathological evaluation to identify lymphoid tissue and metastatic prostate cancer...
November 2017: Current Urology
https://www.readbyqxmd.com/read/29221181/analysis-of-ctcl-cell-lines-reveals-important-differences-between-mycosis-fungoides-s%C3%A3-zary-syndrome-vs-htlv-1-leukemic-cell-lines
#11
Elena Netchiporouk, Jennifer Gantchev, Matthew Tsang, Philippe Thibault, Andrew K Watters, John-Douglas Matthew Hughes, Feras M Ghazawi, Anders Woetmann, Niels Ødum, Denis Sasseville, Ivan V Litvinov
HTLV-1 is estimated to affect ~20 million people worldwide and in ~5% of carriers it produces Adult T-Cell Leukemia/Lymphoma (ATLL), which can often masquerade and present with classic erythematous pruritic patches and plaques that are typically seen in Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most recognized variants of Cutaneous T-Cell Lymphomas (CTCL). For many years the role of HTLV-1 in the pathogenesis of MF/SS has been hotly debated. In this study we analyzed CTCL vs. HTLV-1+ leukemic cells...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29196069/impact-of-allergy-and-resistance-on-antibiotic-selection-for-recurrent-urinary-tract-infections-in-older-women
#12
Rena D Malik, Yuefeng Rose Wu, Alana L Christie, Feras Alhalabi, Philippe E Zimmern
OBJECTIVES: To review the impact of antibiotic allergy and resistance in older women with recurrent urinary tract infections (RUTIs) as determinants for a suitable oral antibiotic treatment choice. METHODS: A prospectively maintained database of women 65 years old and older with documented RUTIs (≥3 UTI/year) and trigonitis on cystoscopy was reviewed. Demographic data, known drug allergies, renal function, antibiotic susceptibility of most recent urine culture, allergy and/or resistance to trimethoprim-sulfamethoxazole (TMP-SMX), fluoroquinolones, and nitrofurantoin were obtained...
November 28, 2017: Urology
https://www.readbyqxmd.com/read/29195144/quantification-of-amlodipine-in-dried-blood-spot-samples-by-high-performance-liquid-chromatography-tandem-mass-spectrometry
#13
Gaoyun Chen, Feras Jirjees, Abdel Al Bawab, James C McElnay
A sensitive and specific method, utilising high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) was developed for the quantitative determination of amlodipine in dried blood spot (DBS) samples. Chromatographic separation was achieved using a Waters XBridge C18 column with gradient elution of a mixture of water and acetonitrile containing 0.1% formic acid (v/v). Amlodipine was quantified using a Waters Quattro Premier mass spectrometer coupled with an electro-spray ionization (ESI) source in positive ion mode...
November 16, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29185924/protocol-for-adhesion-and-immunostaining-of-lymphocytes-and-other-non-adherent-cells-in-culture
#14
Matthew Tsang, Jennifer Gantchev, Feras M Ghazawi, Ivan V Litvinov
Immunostaining of non-adherent cells is commonly performed after adhesion of cells onto microscope slides either using cytocentrifugation or with the help of charged coating substrates. These techniques, however, require either specialized equipment or significant preparation time. Here, we describe a method for immunofluorescent staining of lymphocytes within multi-well culture plates, where cells suspended in phosphate buffered saline (PBS) are adhered to either the plastic well bottom or glass coverslips by gravity sedimentation...
November 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/29170366/initiation-of-hiv-neutralizing-b-cell-lineages-with-sequential-envelope-immunizations
#15
Wilton B Williams, Jinsong Zhang, Chuancang Jiang, Nathan I Nicely, Daniela Fera, Kan Luo, M Anthony Moody, Hua-Xin Liao, S Munir Alam, Thomas B Kepler, Akshaya Ramesh, Kevin Wiehe, James A Holland, Todd Bradley, Nathan Vandergrift, Kevin O Saunders, Robert Parks, Andrew Foulger, Shi-Mao Xia, Mattia Bonsignori, David C Montefiori, Mark Louder, Amanda Eaton, Sampa Santra, Richard Scearce, Laura Sutherland, Amanda Newman, Hilary Bouton-Verville, Cindy Bowman, Howard Bomze, Feng Gao, Dawn J Marshall, John F Whitesides, Xiaoyan Nie, Garnett Kelsoe, Steven G Reed, Christopher B Fox, Kim Clary, Marguerite Koutsoukos, David Franco, John R Mascola, Stephen C Harrison, Barton F Haynes, Laurent Verkoczy
A strategy for HIV-1 vaccine development is to define envelope (Env) evolution of broadly neutralizing antibodies (bnAbs) in infection and to recreate those events by vaccination. Here, we report host tolerance mechanisms that limit the development of CD4-binding site (CD4bs), HCDR3-binder bnAbs via sequential HIV-1 Env vaccination. Vaccine-induced macaque CD4bs antibodies neutralize 7% of HIV-1 strains, recognize open Env trimers, and accumulate relatively modest somatic mutations. In naive CD4bs, unmutated common ancestor knock-in mice Env+B cell clones develop anergy and partial deletion at the transitional to mature B cell stage, but become Env- upon receptor editing...
November 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/29165803/rust-colored-patches-on-the-lower-extremities-lichen-aureus
#16
Simon F Roy, Feras M Ghazawi, Nathalie Provost
No abstract text is available yet for this article.
November 22, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29163376/complete-genome-sequence-analysis-of-enterobacter-sp-sa187-a-plant-multi-stress-tolerance-promoting-endophytic-bacterium
#17
Cristina Andrés-Barrao, Feras F Lafi, Intikhab Alam, Axel de Zélicourt, Abdul A Eida, Ameerah Bokhari, Hanin Alzubaidy, Vladimir B Bajic, Heribert Hirt, Maged M Saad
Enterobacter sp. SA187 is an endophytic bacterium that has been isolated from root nodules of the indigenous desert plant Indigofera argentea. SA187 could survive in the rhizosphere as well as in association with different plant species, and was able to provide abiotic stress tolerance to Arabidopsis thaliana. The genome sequence of SA187 was obtained by using Pacific BioScience (PacBio) single-molecule sequencing technology, with average coverage of 275X. The genome of SA187 consists of one single 4,429,597 bp chromosome, with an average 56% GC content and 4,347 predicted protein coding DNA sequences (CDS), 153 ncRNA, 7 rRNA, and 84 tRNA...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29156170/computed-navigation-guidance-for-ankle-replacement-in-the-setting-of-ankle-deformity
#18
REVIEW
Feras J Waly, Nicholas E Yeo, Murray J Penner
Total ankle replacement (TAR) has evolved over the past decade as a treatment for end-stage ankle arthritis with improved survivorship. Despite the improving outcomes, ankle deformity represents a challenge to the foot and ankle surgeon with increased risk of implant failure. The use of preoperative computer-assisted guidance has led to better understanding the 3-dimensional ankle anatomy and associated deformities and allows for reproducible, anatomic placement of the TAR components.
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29140718/pem-fitter-a-coarse-grained-method-to-validate-protein-candidate-models
#19
Kamal Al Nasr, Christopher Jones, Feras Yousef, Ruba Jebril
The volumetric images produced by Cryo-Electron Microscopy (cryo-EM) technique are used to model macromolecular assemblies and machines. De novo protein modeling uses these images to computationally model the structure of the molecules. Many candidate conformations are usually generated during the intermediate step. Conventionally, each of these candidates is evaluated by time-consuming approaches such as potential energy. We introduce an initial version of a geometrical screening method that uses the skeleton of the cryo-EM images to evaluate candidate structures...
November 15, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29135502/the-crown-jewel-an-enigmatic-solitary-mass-of-follicular-origin-challenge
#20
Simon F Roy, Feras M Ghazawi, Sergio González Bombardiere
No abstract text is available yet for this article.
October 30, 2017: American Journal of Dermatopathology
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