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https://www.readbyqxmd.com/read/29774203/small-rho-gtpases-and-the-effector-vipa-mediate-the-invasion-of-epithelial-cells-by-filamentous-legionella-pneumophila
#1
Akriti Prashar, María Eugenia Ortiz, Stefanie Lucarelli, Elizabeth Barker, Zohreh Tabatabeiyazdi, Feras Shamoun, Deepa Raju, Costin Antonescu, Cyril Guyard, Mauricio R Terebiznik
Legionella pneumophila (Lp) exhibits different morphologies with varying degrees of virulence. Despite their detection in environmental sources of outbreaks and in respiratory tract secretions and lung autopsies from patients, the filamentous morphotype of Lp remains poorly studied. We previously demonstrated that filamentous Lp invades lung epithelial cells (LECs) and replicates intracellularly in a Legionella containing vacuole. Filamentous Lp activates β1integrin and E-cadherin receptors at the surface of LECs leading to the formation of actin-rich cell membrane structures we termed hooks and membrane wraps...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29724988/total-gastric-necrosis-due-to-mucormycosis-a-rare-case-of-gastric-perforation
#2
Salah Termos, Feras Othman, Mohammad Alali, Bader M S Al Bader, Talal Alkhadher, Wael Fathi Hassanaiah, Ali Taqi, Abhijit Sapkal
BACKGROUND Spontaneous gastric perforation is usually a complication of peptic ulcer disease, or a postoperative complication resulting from gastric torsion. Mucormycosis (or zygomycosis) is an uncommon opportunistic fungal infection that is usually seen in immunocompromised patients and is associated with significant morbidity and mortality. This report is of a rare case of spontaneous gastric perforation due to mucormycosis infection. CASE REPORT A 52-year-old woman, with a past medical history of heroin abuse, diabetes mellitus, hypertension, and chronic kidney disease treated by dialysis, presented to the emergency department with cellulitis of the arms...
May 4, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29677021/pericardial-patch-exclusion-technique-for-left-atrial-appendage-closure
#3
Olivia K Ginty, Feras H Khaliel, Corey Adams, Michael W A Chu
We describe a technique of left atrial appendage occlusion that consists of autologous pericardial patch closure of the left atrial appendage orifice from within the left atrium. This pericardial patch exclusion technique has little added risk of bleeding, can be performed through sternotomy or right minithoracotomy, and can be used in re-operative situations.
April 19, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29643259/cerebrovascular-accidents-during-mechanical-circulatory-support-new-predictors-of-ischemic-and-hemorrhagic-strokes-and-outcome
#4
Saef Izzy, Daniel B Rubin, Firas S Ahmed, Feras Akbik, Simone Renault, Katelyn W Sylvester, Henrikas Vaitkevicius, Jennifer A Smallwood, Michael M Givertz, Steven K Feske
BACKGROUND AND PURPOSE: Left ventricular assist devices (LVADs) have emerged as an effective treatment for patients with advanced heart failure refractory to medical therapy. Post-LVAD strokes are an important cause of morbidity and reduced quality of life. Data on risks that distinguish between ischemic and hemorrhagic post-LVAD strokes are limited. The aim of this study was to determine the incidence of post-LVAD ischemic and hemorrhagic strokes, their association with stroke risk factors, and their effect on mortality...
May 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29606917/fera-2017-addressing-head-pose-in-the-third-facial-expression-recognition-and-analysis-challenge
#5
Michel F Valstar, Enrique Sánchez-Lozano, Jeffrey F Cohn, László A Jeni, Jeffrey M Girard, Zheng Zhang, Lijun Yin, Maja Pantic
The field of Automatic Facial Expression Analysis has grown rapidly in recent years. However, despite progress in new approaches as well as benchmarking efforts, most evaluations still focus on either posed expressions, near-frontal recordings, or both. This makes it hard to tell how existing expression recognition approaches perform under conditions where faces appear in a wide range of poses (or camera views), displaying ecologically valid expressions. The main obstacle for assessing this is the availability of suitable data, and the challenge proposed here addresses this limitation...
May 2017: Proceedings of the ... International Conference on Automatic Face and Gesture Recognition
https://www.readbyqxmd.com/read/29571730/hybrid-coronary-revascularization-versus-on-pump-coronary-artery-bypass-grafting
#6
Vincenzo Giambruno, Philip Jones, Feras Khaliel, Michael W Chu, Patrick Teefy, Kumar Sridhar, Cristina Cucchietti, Rebecca Barnfield, Bob Kiaii
BACKGROUND: Hybrid coronary revascularization (HCR) is an evolving coronary revascularization strategy for the treatment of multivessel coronary artery disease. We provide a comparative analysis to conventional on-pump coronary artery bypass graft surgery (CABG) with long-term follow-up. METHODS: We included all double on-pump CABG (n = 682) and HCR (147 robotic-assisted minimally invasive bypass grafts of the left internal thoracic artery to the left anterior descending coronary artery and percutaneous coronary intervention to one of the non-left anterior descending coronary artery vessels) performed in our institution between March 2004 and November 2015...
March 20, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29549293/prognostic-role-of-kir-genes-and-hla-c-after-hematopoietic-stem-cell-transplantation-in-a-patient-cohort-with-acute-myeloid-leukemia-from-a-consanguineous-community
#7
Ameera Gaafar, Atia Sheereen, Fahad Almohareb, Abdelmoneim Eldali, Naeem Chaudhri, Said Y Mohamed, Amr Hanbali, Marwan Shaheen, Feras Alfraih, Riad El Fakih, Alia Iqneibi, Riad Youniss, Tusneem Elhassan, Shahrukh Hashmi, Mahmud Aljurf, Khalid Alhussein
NK cell activity is tuned by a balance of activating and inhibitory signals transmitted via their respective receptors, including killer immunoglobulin-like receptors (KIRs). The impact of NK cells on graft-versus-leukemia following hematopoietic stem cell transplantation (HSCT) is well established. These effects sometimes lead to GvHD. The link between KIR/HLA interaction and GvHD remains unclear. Herein, we studied the impact of the KIR/HLA interaction on HSCT outcomes in a longitudinal follow-up study of a highly consanguineous HLA-matched related cohort...
March 16, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29549260/hiv-envelope-v3-region-mimic-embodies-key-features-of-a-broadly-neutralizing-antibody-lineage-epitope
#8
Daniela Fera, Matthew S Lee, Kevin Wiehe, R Ryan Meyerhoff, Alessandro Piai, Mattia Bonsignori, Baptiste Aussedat, William E Walkowicz, Therese Ton, Jeffrey O Zhou, Samuel Danishefsky, Barton F Haynes, Stephen C Harrison
HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide ("Man9 -V3") for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage ("DH270"), to visualize the epitope on Env and to study how affinity maturation of the lineage proceeded. Unlike many previous V3 mimetics, Man9 -V3 encompasses two key features of the V3 region recognized by V3-glycan bnAbs-the conserved GDIR motif and the N332 glycan...
March 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29508146/correction-to-emergency-medicine-in-the-kingdom-of-bahrain
#9
Feras Abuzeyad, Leena Alqasem, Mudhaffar I Al Farras, Shaikha S Al Jawder, Ghada Al Qasim, Salah Alghanem
Following the publication of the original article [1], it was brought to our attention that author Leena Alqasem was erroneously included as Leena Alqusem.
March 5, 2018: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29477781/treatment-effect-in-earlier-trials-of-patients-with-chronic-medical-conditions-a-meta-epidemiologic-study
#10
Fares Alahdab, Wigdan Farah, Jehad Almasri, Patricia Barrionuevo, Feras Zaiem, Raed Benkhadra, Noor Asi, Mouaz Alsawas, Yifan Pang, Ahmed T Ahmed, Tamim Rajjo, Amrit Kanwar, Khalid Benkhadra, Zayd Razouki, M Hassan Murad, Zhen Wang
OBJECTIVE: To determine whether the early trials in chronic medical conditions demonstrate an effect size that is larger than that in subsequent trials. METHODS: We identified randomized controlled trials (RCTs) evaluating a drug or device in patients with chronic medical conditions through meta-analyses (MAs) published between January 1, 2007, and June 23, 2015, in the 10 general medical journals with highest impact factor. We estimated the prevalence of having the largest effect size or heterogeneity in the first 2 published trials...
March 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29471441/retraction-to-functional-results-after-chest-wall-stabilization-with-a-new-screwless-fixation-device-eur-j-cardiothorac-surg-2015-47-868-75
#11
Mark Nikolaj Wiese, Nadine Kawel-Boehm, Pablo Moreno de la Santa, Feras Al-Shahrabani, Melanie Toffel, Rachel Rosenthal, Juliane Schäfer, Michael Tamm, Jens Bremerich, Didier Lardinois
No abstract text is available yet for this article.
March 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29471027/cytotoxic-homoisoflavonoids-from-the-bulbs-of-bellevalia-flexuosa
#12
Tamam El-Elimat, José Rivera-Chávez, Joanna E Burdette, Austin Czarnecki, Maram B Alhawarri, Mohammad Al-Gharaibeh, Feras Alali, Nicholas H Oberlies
Four new homoisoflavonoids, 7-O-methyl-8-demethoxy-3'-hydroxy-3,9-dihydropunctatin (4), 6-hydroxy-8-demethoxy-4'-O-methyl-3,9-dihydropunctatin (8), 7,4'-O-dimethyl-8-demethoxy-3,3'-dihydroxy-3,9-dihydropunctatin (13), and 7-O-methyl-3-hyroxy-3,9-dihydropunctatin (14) were identified from a chloroform extract of the bulbs of Bellevalia flexuosa, along with 13 known analogues. The structures were determined by analysis of HRMS and NMR data, while ECD spectroscopy enabled the assignment of the absolute configurations of the new compounds 4, 8, 13 and 16...
February 20, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29469162/investigating-enhanced-thermoelectric-performance-of-graphene-based-nano-structures
#13
Md Sharafat Hossain, Duc Hau Huynh, Liming Jiang, Sharmin Rahman, Phuong Duc Nguyen, Feras Al-Dirini, Faruque Hossain, Je-Hyeong Bahk, Efstratios Skafidas
Recently, it has been demonstrated that graphene nano-ribbons (GNRs) exhibit superior thermoelectric performance compared to graphene sheets. However, the underlying mechanism behind this enhancement has not been systematically investigated and significant opportunity remains for further enhancement of the thermoelectric performance of GNRs by optimizing their charge carrier concentration. In this work, we modulate the carrier concentration of graphene-based nano-structures using a gate voltage and investigate the resulting carrier-concentration-dependent thermoelectric parameters using the Boltzmann transport equations...
March 8, 2018: Nanoscale
https://www.readbyqxmd.com/read/29464581/urinary-neutrophil-gelatinase-associated-lipocalin-ngal-and-serum-cystatin-c-measurements-for-early-diagnosis-of-acute-kidney-injury-in-children-admitted-to-picu
#14
Jameela Abdulaziz Kari, Mohamed Ahmed Shalaby, Kholoud Sofyani, Ahmad Saleh Sanad, Albaraa Fuad Ossra, Rayan Smeer Halabi, Maha Hassan Aljuhani, Wael Mohammad Toffaha, Feras Aymen Moria, Samar Sabry, Hanan AbdelAziz Ahmed, Khalid Abdulaziz Alhasan, Sara Sharief, Osama Safdar
BACKGROUND: Acute kidney injury (AKI) is common in critically ill children with significant mortality and morbidity. Serum creatinine is an insensitive and late biomarker compared to newly proposed AKI biomarkers. METHODS: Prospective study in pediatric intensive care unit (PICU) over three months to compare between serum cystatin-C (s-Cys-C) and urinary neutrophil gelatinase-associated lipocalin (uNGAL) as AKI biomarkers at multiple time points with pediatric risk, injury, failure, loss, end-stage renal disease (pRIFLE) classification in diagnosing AKI...
April 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29435284/-18-f-fluoro-2-deoxyglucose-positron-emission-computed-tomography-in-a-rare-cutaneous-form-of-rosai-dorfman-disease-a-case-report
#15
Joya Hadchiti, Francois G Kamar, Jean Abi Ghosn, Mohamad Haidar, Ahmad Younes, Antoine Obeid, Marwan Haddad, Fadi Farhat, Feras Chehade
Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, commonly involves the lymph nodes but may secondarily involve the skin. Purely cutaneous disease without lymphatics or internal organ involvement occurs rarely. The present report detailed a rare case of 18 F-fluoro-2-deoxyglucose positron emission-computed tomography (18 FDG PET-CT) performed in a 33-year-old male soldier with a purely cutaneous form of RDD. Staging with 18 FDG PET-CT was ordered prior to excisional biopsies of the aforedescribed masses and pathology reported RDD...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29427201/use-of-fully-threaded-cannulated-screws-decreases-femoral-neck-shortening-after-fixation-of-femoral-neck-fractures
#16
Yoram A Weil, Feras Qawasmi, Meir Liebergall, Rami Mosheiff, Amal Khoury
BACKGROUND: Femoral neck fractures (FNF) are becoming increasingly common as population ages. Nondisplaced fractures are commonly treated by cancellous, parallel placed, partially threaded cannulated screws (PTS). This allows controlled fracture impaction. However, sliding implants can lead to femoral neck shortening (FNS) that has been shown to be correlated with reduced quality of life and impaired gait pattern. Recently, in our institution we have changed the fixation of FNF to fully threaded screws (FTS) with or without an additional partially threaded screw in order to minimize this phenomenon...
May 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29423875/emergency-medicine-in-the-kingdom-of-bahrain
#17
Feras Abuzeyad, Leena Alqasem, Mudhaffar I Al Farras, Shaikha S Al Jawder, Ghada Al Qasim, Salah Alghanem
It has been more than a decade since emergency medicine became recognized as a specialty in the Kingdom of Bahrain. In the last fifteen years emergency medicine has widely established itself and developed rapidly in the Kingdom. The three main emergency departments are: Salmanyia Medical Complex (SMC), Royal Medical Services of Bahrain Defence Force (RMS-BDF) and King Hamad University Hospital (KHUH) are now fully equipped and operated by a majority of board certified emergency physicians.Standardized protocols, and the Central National Ambulance will be established in the near future, and the ambulances will offer both basic and advanced life support by trained nurses and paramedics...
February 8, 2018: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29411175/will-the-presence-of-radiological-signs-of-tension-pneumothorax-affect-the-clinical-presentation-of-primary-spontaneous-pneumothorax
#18
Yasser Aljehani, Feras Almajid, Hind Alsaif
INTRODUCTION: Patients with primary spontaneous pneumothorax (PSP) rarely presented with radiological signs of tension pneumothorax on their presenting chest X-ray. Even though, those patients may not develop the hemodynamic instability that is seen in tension pneumothorax. The aim of this study is to elaborate whether the presence of radiological signs of tension pneumothorax in patients with PSP will affect their clinical presentation. METHODS: Retrospective study of all cases of PSP over a period from January 2007 to December 2014...
February 6, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29380286/diagnostic-value-of-stress-thallium-201-rest-technetium-99m-sestamibi-sequential-dual-isotope-high-speed-myocardial-perfusion-imaging-for-the-detection-of-haemodynamically-relevant-coronary-artery-stenosis
#19
Gilles Barone-Rochette, Feras Zoreka, Loïc Djaileb, Nicolas Piliero, Alex Calizzano, Jean Louis Quesada, Alexis Broisat, Laurent Riou, Jacques Machecourt, Daniel Fagret, Gerald Vanzetto, Catherine Ghezzi
BACKGROUND: The aim of this study was to determine the diagnostic accuracy of stress thallium-201/rest technetium-99m-sestamibi sequential dual-isotope high-speed myocardial perfusion imaging (DI-HS-MPI) against invasively determined fractional flow reserve (FFR). METHODS: Fifty-four consecutive patients prospectively underwent DI-HS-MPI before invasive coronary angiography. Perfusion was scored visually by summed stress score on a patient and coronary territory basis...
January 29, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29374031/bacterial-catabolism-of-%C3%AE-hydroxypropiovanillone-and-%C3%AE-hydroxypropiosyringone-produced-in-the-reductive-cleavage-of-arylglycerol-%C3%AE-aryl-ether-in-lignin
#20
Yudai Higuchi, Shogo Aoki, Hiroki Takenami, Naofumi Kamimura, Kenji Takahashi, Shojiro Hishiyama, Christopher S Lancefield, O Stephen Ojo, Yoshihiro Katayama, Nicholas J Westwood, Eiji Masai
Sphingobium sp. strain SYK-6 converts four stereoisomers of arylglycerol-β-guaiacyl ether into achiral β-hydroxypropiovanillone (HPV) via three stereospecific reaction steps. Here, we determined the HPV catabolic pathway and characterized the HPV catabolic genes involved in the first two steps of the pathway. In SYK-6 cells, HPV was oxidized to vanilloyl acetic acid (VAA) via vanilloyl acetaldehyde (VAL). The resulting VAA was further converted into vanillate through the activation of VAA by coenzyme A. A syringyl-type HPV analog, β-hydroxypropiosyringone (HPS), was also catabolized via the same pathway...
April 1, 2018: Applied and Environmental Microbiology
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