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https://www.readbyqxmd.com/read/28918842/anorectal-malignant-melanoma-presenting-as-acute-pancreatitis
#1
Feras Zaiem, Abdulah Alrifai
No abstract text is available yet for this article.
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28894681/preoperative-computed-tomography-myelography-parameters-as-predictors-of-outcome-in-patients-with-degenerative-cervical-myelopathy-results-of-a-systematic-review
#2
Feras J Waly, Fahad H Abduljabbar, Maryse Fortin, Anas Nooh, Michael Weber
STUDY DESIGN: Systematic review. OBJECTIVES: To determine the preoperative computed tomography (CT) myelogram imaging parameters in patients diagnosed with degenerative cervical myelopathy (DCM) that correlate with severity of DCM and predict postoperative patients' functional outcome. METHODS: An electronic database search was performed using Ovid Medline and Embase. CT myelogram studies investigating the correlation between imaging characteristics and DCM severity or postoperative outcomes were included...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28890946/oncokb-a-precision-oncology-knowledge-base
#3
Debyani Chakravarty, Jianjiong Gao, Sarah M Phillips, Ritika Kundra, Hongxin Zhang, Jiaojiao Wang, Julia E Rudolph, Rona Yaeger, Tara Soumerai, Moriah H Nissan, Matthew T Chang, Sarat Chandarlapaty, Tiffany A Traina, Paul K Paik, Alan L Ho, Feras M Hantash, Andrew Grupe, Shrujal S Baxi, Margaret K Callahan, Alexandra Snyder, Ping Chi, Daniel Danila, Mrinal Gounder, James J Harding, Matthew D Hellmann, Gopa Iyer, Yelena Janjigian, Thomas Kaley, Douglas A Levine, Maeve Lowery, Antonio Omuro, Michael A Postow, Dana Rathkopf, Alexander N Shoushtari, Neerav Shukla, Martin Voss, Ederlinda Paraiso, Ahmet Zehir, Michael F Berger, Barry S Taylor, Leonard B Saltz, Gregory J Riely, Marc Ladanyi, David M Hyman, José Baselga, Paul Sabbatini, David B Solit, Nikolaus Schultz
PURPOSE: With prospective clinical sequencing of tumors emerging as a mainstay in cancer care, there is an urgent need for a clinical support tool that distills the clinical implications associated with specific mutation events into a standardized and easily interpretable format. To this end, we developed OncoKB, an expert-guided precision oncology knowledge base. METHODS: OncoKB annotates the biological and oncogenic effect and the prognostic and predictive significance of somatic molecular alterations...
July 2017: JCO Precis Oncol
https://www.readbyqxmd.com/read/28881497/therapies-for-advanced-stage-hepatocellular-carcinoma-with-macrovascular-invasion-or-metastatic-disease-a-systematic-review-and-meta-analysis
#4
REVIEW
Richard S Finn, Andrew X Zhu, Farah Wigdan, Jehad Almasri, Feras Zaiem, Larry J Prokop, Mohammad Hassan Murad, Khaled Mohammed
Hepatocellular carcinoma (HCC) is a complex disease most commonly arising in the background of chronic liver disease. In the past two decades there has been a significant increase in our understanding of both the clinical and molecular heterogeneity of HCC. There has been a robust increase in clinical trial activity in patients with poor prognostic factors such as macrovascular invasion and extrahepatic spread. We aimed to synthesize the evidence for the treatment of patients with advanced HCC based on these baseline characteristics including patients with both Child-Pugh scores of A and B...
September 7, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28871716/the-influence-of-eruca-sativa-arugula-on-pharmacokinetics-of-sildenafil-in-rats
#5
Eyad Mallah, Soadad Saleh, Walid Abu Rayyan, Wael Abu Dayyih, Feras Darwish Elhajji, Mohammed Mima, Riad Awad, Tawfiq Arafat
OBJECTIVES: A drug like Sildenafil is commonly used for the treatment of erectile dysfunction. Eruca sativa is known as a garden plant used in folk medicine to enhance the sexual desire in males. Nevertheless, the interaction of Sildenafil and Eruca sativa was not studied. In the current study, we aimed to examine the influence of Eruca sativa on Sildenafil pharmacokinetics in rats. STUDY DESIGN: A crossover experiment with washout period of two weeks was conducted...
August 5, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28859233/imaging-for-the-diagnosis-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#6
REVIEW
Lewis R Roberts, Claude B Sirlin, Feras Zaiem, Jehad Almasri, Larry J Prokop, Julie Heimbach, M Hassan Murad, Khaled Mohammed
Multiphasic computed tomography (CT) and magnetic resonance imaging (MRI) are both used for non-invasive diagnosis of hepatocellular carcinoma (HCC) in patients with cirrhosis. To determine if there is a relative diagnostic benefit of one over the other, we synthesized evidence regarding the relative performances of CT, extracellular-contrast-enhanced-MRI, and gadoxetate-enhanced-MRI for diagnosis of HCC in patients with cirrhosis. We also assessed whether liver biopsy versus follow-up with the same versus alternative imaging is best for CT- or MRI-indeterminate liver nodules in patients with cirrhosis...
August 31, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28859222/therapies-for-patients-with-hepatocellular-carcinoma-awaiting-for-liver-transplantation-a-systematic-review-and-meta-analysis
#7
REVIEW
Laura Kulik, Julie K Heimbach, Feras Zaiem, Jehad Almasri, Larry J Prokop, Zhen Wang, M Hassan Murad, Khaled Mohammed
Patients with hepatocellular carcinoma (HCC) who are listed for liver transplantation are often treated while on the waiting list with loco-regional therapy (LRT) which is aimed at either preventing progression of HCC or reducing themeasurable disease burden of HCC in order to receive increased allocation priority. We aimed to synthesize evidence regarding the effectiveness of LRT in the management of patients with HCC who were on the liver transplant waitlist. We conducted a comprehensive search of multiple databases from 1996 to April 25, 2016, for studies that enrolled adults with cirrhosis awaiting liver transplantation and treated with bridging or down-staging therapies before liver transplantation...
August 31, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28859190/comparative-effectiveness-and-safety-of-cognitive-behavioral-therapy-and-pharmacotherapy-for-childhood-anxiety-disorders-a-systematic-review-and-meta-analysis
#8
Zhen Wang, Stephen P H Whiteside, Leslie Sim, Wigdan Farah, Allison S Morrow, Mouaz Alsawas, Patricia Barrionuevo, Mouaffaa Tello, Noor Asi, Bradley Beuschel, Lubna Daraz, Jehad Almasri, Feras Zaiem, Laura Larrea-Mantilla, Oscar J Ponce, Annie LeBlanc, Larry J Prokop, Mohammad Hassan Murad
Importance: Childhood anxiety is common. Multiple treatment options are available, but existing guidelines provide inconsistent advice on which treatment to use. Objectives: To evaluate the comparative effectiveness and adverse events of cognitive behavioral therapy (CBT) and pharmacotherapy for childhood anxiety disorders. Data Sources: We searched MEDLINE, EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and SciVerse Scopus from database inception through February 1, 2017...
August 31, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28857776/cha2ds2-vasc-score-and-exercise-capacity-of-patients-with-coronary-artery-disease-participating-in-cardiac-rehabilitation-programs
#9
Feras Haskiah, Yacov Shacham, Saar Minha, Zach Rozenbaum, David Pereg
BACKGROUND: Exercise based cardiac rehabilitation improves prognosis and quality of life in patients with coronary artery disease. We aimed to investigate whether the CHA2DS2-VASc score may be a predictor of improvement in exercise capacity in acute coronary syndrome (ACS) patients participating in a cardiac rehabilitation program. METHODS: Included were patients following a hospital admission due to ACS and were subsequently referred for an exercise based cardiac rehabilitation during 2010-2015...
August 29, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28840047/complete-laparoscopic-extirpation-of-a-giant-ovarian-cyst-in-an-adolescent
#10
Saeed Baradwan, Feras Sendy, Sameer Sendy
The giant ovarian serous cystadenoma is a rare finding and often benign. The use of the laparoscopic approach versus open approach for the management of huge ovarian cysts is controversial. We report a case of a 27-year-old woman with a history of increasing abdominal girth over a period of two years along with radiological investigations revealed a large tumor arising from the right ovary treated by complete laparoscopic extirpation of a giant ovarian cyst. The complete laparoscopic approach for huge cyst is a feasible treatment when having a normal tumor marker profile and benign imaging appearance...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28827392/spermatogonial-kinetics-in-the-human
#11
Sara Di Persio, Rossana Saracino, Stefania Fera, Barbara Muciaccia, Valentina Esposito, Carla Boitani, Bartolomeo P Berloco, Francesco Nudo, Gustavo Spadetta, Mario Stefanini, Dirk G de Rooij, Elena Vicini
The human spermatogonial compartment is essential for daily production of millions of sperm. Despite this crucial role, the molecular signature, kinetic behavior and regulation of human spermatogonia are poorly understood. Using human testis biopsies with normal spermatogenesis and studying marker protein expression, for the first time we identified different subpopulations of spermatogonia. MAGE-A4 marks all spermatogonia, KIT marks all B spermatogonia and UCLH1 all Apale-dark (Ap-d) spermatogonia. We suggest that at the start of the spermatogenic lineage there are Ap-d spermatogonia that are GFRA1(High) likely including the spermatogonial stem cells...
August 21, 2017: Development
https://www.readbyqxmd.com/read/28814901/prediction-of-drug-related-problems-in-diabetic-outpatients-in-a-number-of-hospitals-using-a-modeling-approach
#12
Ghaith M Al-Taani, Sayer I Al-Azzam, Karem H Alzoubi, Feras W Darwish Elhajji, Michael G Scott, Hamzah Alfahel, Mamoon A Aldeyab
OBJECTIVE: Drug-related problems (DRPs) are considered a serious, expensive, and important undesirable complication of health care. However, as current health care resources are limited, pharmacist DRP services cannot be provided to all patients. Using a modeling approach, we aimed to identify risk factors for DRPs so that patients for DRP-reduction services can be better identified. METHODS: Patients with diabetes from outpatient clinics from five key university-affiliated and public hospitals in Jordan were assessed for DRPs (drug without an indication, untreated indication, and drug efficacy problems)...
2017: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/28794020/adenovirus-core-protein-vii-down-regulates-the-dna-damage-response-on-the-host-genome
#13
Daphne C Avgousti, Ashley N Della Fera, Clayton J Otter, Christin Herrmann, Neha J Pancholi, Matthew D Weitzman
Viral manipulation of cellular proteins allows viruses to suppress host defenses and generate infectious progeny. Due to the linear double-stranded DNA nature of the adenovirus genome, the cellular DNA damage response (DDR) is considered a barrier for successful infection. The adenovirus genome is packaged with protein VII, a viral-encoded histone-like core protein that is suggested to protect incoming viral genomes from detection by cellular DNA damage machinery. We showed that protein VII localizes to host chromatin during infection, leading us to hypothesize that protein VII may affect DNA damage responses on the cellular genome...
August 9, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28772446/synthesis-of-graphene-based-membranes-effect-of-substrate-surface-properties-on-monolayer-graphene-transfer
#14
Feras Kafiah, Zafarullah Khan, Ahmed Ibrahim, Muataz Atieh, Tahar Laoui
In this work, we report the transfer of graphene onto eight commercial microfiltration substrates having different pore sizes and surface characteristics. Monolayer graphene grown on copper by the chemical vapor deposition (CVD) process was transferred by the pressing method over the target substrates, followed by wet etching of copper to obtain monolayer graphene/polymer membranes. Scanning electron microscopy (SEM), atomic force microscopy (AFM), and contact angle (CA) measurements were carried out to explore the graphene layer transferability...
January 21, 2017: Materials
https://www.readbyqxmd.com/read/28770575/recommendations-for-the-implementation-of-who-framework-convention-on-tobacco-control-article-14-on-tobacco-cessation-support
#15
EDITORIAL
Martin Raw, Olalekan Ayo-Yusuf, Frank Chaloupka, Michael Fiore, Thomas Glynn, Feras Hawari, Judith Mackay, Ann McNeill, Srinath Reddy
No abstract text is available yet for this article.
August 2, 2017: Addiction
https://www.readbyqxmd.com/read/28764682/informing-tobacco-control-policy-in-jordan-assessing-the-effectiveness-of-pictorial-warning-labels-on-cigarette-packs
#16
Rasha K Bader, Rawan A Shihab, Dalia H Al-Rimawi, Feras I Hawari
BACKGROUND: Pictorial warning labels (PWLs) deter initiation and motivate quitting. Assessing PWLs is important to track effectiveness and wear out. Jordan introduced an updated set of PWLs in 2013. This study assessed the effectiveness of the set after 2.5 years on the market. METHODS: We administered a survey in a cross-sectional sample of young adults aged 17-26 years. For convenience, respondents were recruited on university campuses. For heterogeneity, respondents were solicited from the different schools in four geographically diverse university campuses...
August 1, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28757252/non-neutralizing-antibodies-alter-the-course-of-hiv-1-infection-in%C3%A2-vivo
#17
Joshua A Horwitz, Yotam Bar-On, Ching-Lan Lu, Daniela Fera, Ainsley A K Lockhart, Julio C C Lorenzi, Lilian Nogueira, Jovana Golijanin, Johannes F Scheid, Michael S Seaman, Anna Gazumyan, Susan Zolla-Pazner, Michel C Nussenzweig
Non-neutralizing antibodies (nnAbs) to HIV-1 show little measurable activity in prevention or therapy in animal models yet were the only correlate of protection in the RV144 vaccine trial. To investigate the role of nnAbs on HIV-1 infection in vivo, we devised a replication-competent HIV-1 reporter virus that expresses a heterologous HA-tag on the surface of infected cells and virions. Anti-HA antibodies bind to, but do not neutralize, the reporter virus in vitro. However, anti-HA protects against infection in humanized mice and strongly selects for nnAb-resistant viruses in an entirely Fc-dependent manner...
August 10, 2017: Cell
https://www.readbyqxmd.com/read/28756047/effectiveness-of-surgical-interventions-for-thoracic-aortic-aneurysms-a-systematic-review-and-meta-analysis
#18
REVIEW
Mouaz Alsawas, Feras Zaiem, Laura Larrea-Mantilla, Jehad Almasri, Patricia J Erwin, Gilbert R Upchurch, M Hassan Murad
OBJECTIVE: A systematic review and meta-analysis was conducted to evaluate the effectiveness of thoracic endovascular aortic repair (TEVAR) and open repair in patients with descending thoracic aortic aneurysms (TAAs). METHODS: PubMed, Ovid MEDLINE, Ovid Embase, EBSCO Cumulative Index to Nursing and Allied Health Literature, and Scopus were searched from each database's inception to January 29, 2016. We selected studies that compared the two approaches in adults with TAAs and reported 30-day mortality or procedure complications...
July 26, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28751034/current-concepts-on-hematopoietic-stem-cell-transplantation-outcome-registries-emphases-on-resource-requirements-for-new-registries
#19
REVIEW
Fazal Hussain, Naeem Chaudhri, Feras Alfraih, Mahmoud Aljurf
There is tremendous variability in size, scope, and resource requirements for registries depending on the number of patients and participating sites. The outcome registries are organized systems to collect uniform data using an observational study methodology. Patient registries are used to determine specified outcomes for a population for predetermined scientific, clinical, or policy purposes. Historically, outcome registries established in the development of hematopoietic stem cell transplantation (HSCT) have now evolved into myriads of locoregional and international transplant activity and outcome resources...
July 19, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28705053/cardiac-amyloidosis-pathogenesis-clinical-context-diagnosis-and-management-options
#20
Hassan Alkhawam, Darshan Patel, James Nguyen, Saumya Mariam Easaw, Mohammed Al-Sadawi, Umer Syed, Feras Zaiem, Maher Homsi, Timothy J Vittorio
Amyloidosis covers a group of disorders that can manifest in virtually any organ system in the body and is thought to be secondary to misfolding of extracellular proteins with subsequent deposition in tissues. The precursor protein that is produced in excess defines the specific amyloid type. This requires histopathological confirmation using Congo-red dye with its characteristic demonstration of green birefringence under cross-polarized light. There are three main types of amyloidosis associated with cardiac involvement: light-chain (AL), familial or senile (ATTR), and secondary (AA) amyloidosis...
August 2017: Acta Cardiologica
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