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https://www.readbyqxmd.com/read/29156170/computed-navigation-guidance-for-ankle-replacement-in-the-setting-of-ankle-deformity
#1
REVIEW
Feras J Waly, Nicholas E Yeo, Murray J Penner
Total ankle replacement (TAR) has evolved over the past decade as a treatment for end-stage ankle arthritis with improved survivorship. Despite the improving outcomes, ankle deformity represents a challenge to the foot and ankle surgeon with increased risk of implant failure. The use of preoperative computer-assisted guidance has led to better understanding the 3-dimensional ankle anatomy and associated deformities and allows for reproducible, anatomic placement of the TAR components.
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29140718/pem-fitter-a-coarse-grained-method-to-validate-protein-candidate-models
#2
Kamal Al Nasr, Christopher Jones, Feras Yousef, Ruba Jebril
The volumetric images produced by Cryo-Electron Microscopy (cryo-EM) technique are used to model macromolecular assemblies and machines. De novo protein modeling uses these images to computationally model the structure of the molecules. Many candidate conformations are usually generated during the intermediate step. Conventionally, each of these candidates is evaluated by time-consuming approaches such as potential energy. We introduce an initial version of a geometrical screening method that uses the skeleton of the cryo-EM images to evaluate candidate structures...
November 15, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29135502/the-crown-jewel-an-enigmatic-solitary-mass-of-follicular-origin-challenge
#3
Simon F Roy, Feras M Ghazawi, Sergio González Bombardiere
No abstract text is available yet for this article.
October 30, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29096207/avoidant-personality-disorder-and-social-phobia-does-mindreading-make-the-difference
#4
Giovanni Pellecchia, Fabio Moroni, Livia Colle, Antonio Semerari, Antonino Carcione, Teresa Fera, Donatella Fiore, Giuseppe Nicolò, Roberto Pedone, Michele Procacci
OBJECTIVE: Avoidant personality disorder (AvPD) is closely related to and partially overlaps with social phobia (SP). There is an ongoing debate as to whether AvPD and SP can be classified as separate and distinct disorders or whether these diagnoses rather reflect different degrees of severity of social anxiety. The hypothesis of this study is that in patients with AvPD and in those with AvPD and comorbid SP both interpersonal functioning and metacognitive abilities (the ability to understand mental states) are more severely impaired than they are in patients with SP only...
September 28, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29094407/a-retrospective-analysis-of-post-transplant-lymphoproliferative-disorder-following-liver-transplantation
#5
Feras Al Fararjeh, Shameem Mahmood, Phaedra Tachtatzis, Deborah Yallop, Stephen Devereux, Piers Patten, Kosh Agrawal, Abid Suddle, John O'Grady, Nigel Heaton, Robert Marcus, Shireen Kassam
OBJECTIVE: To evaluate response rates and survival in adults developing post-transplant lymphoproliferative disorder (PTLD) following liver transplantation METHODS: Patients were identified retrospectively and data collected through local liver and haematology electronic databases and pharmacy records. RESULTS: Forty-five patients were identified. The median age at first transplant and at development of PTLD was 48 and 54 years respectively, with the median time from transplant to PTLD diagnosis of 56 months...
November 1, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29082469/evaluation-of-the-effect-of-moringa-peregrina-extract-on-learning-and-memory-role-of-oxidative-stress
#6
Karem H Alzoubi, Nasab Q Rawashdeh, Omar F Khabour, Tamam El-Elimat, Hanan Albataineh, Hamzeh M Al-Zghool, Feras Q Alali
Oxidative stress interferes with the functional roles of the hippocampus and results in cognitive decline. Antioxidant supplementation has a cognitive enhancing activity through protecting hippocampus brain cells from the damaging effects of the reactive oxygen species. The dried methanolic extract of the aboveground parts of Moringa peregrina (Forssk.) Fiori (Moringaceae) was hypothesized to have memory-enhancing activity via its antioxidative properties. HPLC and LC-MS methods were used for qualitative analysis of the marker compounds...
October 30, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29074732/how-safe-are-ace-inhibitors-for-heart-failure-in-children
#7
Marijke van der Meulen, Michiel Dalinghaus, Michael Burch, Andras Szatmari, Cristina Castro Diez, Feras Khalil, Vanessa Swoboda, Johannes Breur, Milica Bajcetic, Ida Jovanovic, Florian B Lagler, Ingrid Klingmann, Stephanie Laeer, Saskia N de Wildt
No abstract text is available yet for this article.
October 26, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29023855/hepatitis-c-virus-infection-in-jeddah-city-saudi-arabia-seroprevalence-and-knowledge
#8
Rajaa M Al-Raddadi, Noha A Dashash, Hani A Alghamdi, Zeyad M Al-Raddadi, Hanan S Alzahrani, Abdullah J Alsahafi, Abdullah M Algarni, Majed M Alghamdi, Raghad F Hakim, Abdulmohsen H Al-Zalabani, Fanar Hakim, Feras Ayman Moria
BACKGROUND: The infection rate of the hepatitis C virus (HCV) in Saudi Arabia is among the lowest in the world. However, it is likely that poor knowledge and awareness of HCV infection could minimize the effectiveness of prevention and control programs in the kingdom. OBJECTIVES: Thus, the study objective was to estimate the prevalence of HCV infection, and to assess current knowledge about it, in the targeted population. METHODS: Data on 5482 Saudi people attending primary healthcare centers in Jeddah City in 2014/2015 were analyzed in this cross-sectional study...
October 11, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28948856/preliminary-dual-center-experience-with-the-bolton-treovance-endograft
#9
MULTICENTER STUDY
Arron Thind, Dhruv Sarma, Abdel Kader Allouni, Feras Abdallah, David Murray, Kiran Thind, Chris Darby, Ashok Handa, Ed Sideso, Rafiuddin Patel, Mark Bratby, Raman Uberoi
PURPOSE: To present the performance and safety of the Treovance stent graft for endovascular aortic aneurysm repair in a "real-world" patient cohort. METHODS: Patients from 2 centers, deemed unfit for open repair, were electively treated with the Treovance endograft. Clinical preoperative, operative, and up to 1-year postoperative follow-up data of patients were retrospectively analyzed. RESULTS: This study included 46 patients with abdominal aortic aneurysm (44 male), mean age of 78 years ± 8 standard deviation (SD; range: 58-93 years)...
November 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28942781/ishlt-transplant-registry-youthful-investment-the-path-to-progress
#10
EDITORIAL
Evan P Kransdorf, Hirsch S Mehta, Keyur B Shah, Darko Vucicevic, Eugene C DePasquale, Livia Goldraich, Agnieszka Ciarka, Marco Masetti, Jong-Chan Youn, Claire Irving, Feras Khaliel, Martin Schweiger, Patricia Uber, Mandeep R Mehra, Josef Stehlik
No abstract text is available yet for this article.
October 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28918842/anorectal-malignant-melanoma-presenting-as-acute-pancreatitis
#11
Feras Zaiem, Abdulah Alrifai
No abstract text is available yet for this article.
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28894681/preoperative-computed-tomography-myelography-parameters-as-predictors-of-outcome-in-patients-with-degenerative-cervical-myelopathy-results-of-a-systematic-review
#12
Feras J Waly, Fahad H Abduljabbar, Maryse Fortin, Anas Nooh, Michael Weber
STUDY DESIGN: Systematic review. OBJECTIVES: To determine the preoperative computed tomography (CT) myelogram imaging parameters in patients diagnosed with degenerative cervical myelopathy (DCM) that correlate with severity of DCM and predict postoperative patients' functional outcome. METHODS: An electronic database search was performed using Ovid Medline and Embase. CT myelogram studies investigating the correlation between imaging characteristics and DCM severity or postoperative outcomes were included...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28890946/oncokb-a-precision-oncology-knowledge-base
#13
Debyani Chakravarty, Jianjiong Gao, Sarah M Phillips, Ritika Kundra, Hongxin Zhang, Jiaojiao Wang, Julia E Rudolph, Rona Yaeger, Tara Soumerai, Moriah H Nissan, Matthew T Chang, Sarat Chandarlapaty, Tiffany A Traina, Paul K Paik, Alan L Ho, Feras M Hantash, Andrew Grupe, Shrujal S Baxi, Margaret K Callahan, Alexandra Snyder, Ping Chi, Daniel Danila, Mrinal Gounder, James J Harding, Matthew D Hellmann, Gopa Iyer, Yelena Janjigian, Thomas Kaley, Douglas A Levine, Maeve Lowery, Antonio Omuro, Michael A Postow, Dana Rathkopf, Alexander N Shoushtari, Neerav Shukla, Martin Voss, Ederlinda Paraiso, Ahmet Zehir, Michael F Berger, Barry S Taylor, Leonard B Saltz, Gregory J Riely, Marc Ladanyi, David M Hyman, José Baselga, Paul Sabbatini, David B Solit, Nikolaus Schultz
PURPOSE: With prospective clinical sequencing of tumors emerging as a mainstay in cancer care, there is an urgent need for a clinical support tool that distills the clinical implications associated with specific mutation events into a standardized and easily interpretable format. To this end, we developed OncoKB, an expert-guided precision oncology knowledge base. METHODS: OncoKB annotates the biological and oncogenic effect and the prognostic and predictive significance of somatic molecular alterations...
July 2017: JCO Precis Oncol
https://www.readbyqxmd.com/read/28881497/therapies-for-advanced-stage-hepatocellular-carcinoma-with-macrovascular-invasion-or-metastatic-disease-a-systematic-review-and-meta-analysis
#14
REVIEW
Richard S Finn, Andrew X Zhu, Farah Wigdan, Jehad Almasri, Feras Zaiem, Larry J Prokop, Mohammad Hassan Murad, Khaled Mohammed
Hepatocellular carcinoma (HCC) is a complex disease most commonly arising in the background of chronic liver disease. In the past two decades there has been a significant increase in our understanding of both the clinical and molecular heterogeneity of HCC. There has been a robust increase in clinical trial activity in patients with poor prognostic factors such as macrovascular invasion and extrahepatic spread. We aimed to synthesize the evidence for the treatment of patients with advanced HCC based on these baseline characteristics including patients with both Child-Pugh scores of A and B...
September 7, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28871716/the-influence-of-eruca-sativa-arugula-on-pharmacokinetics-of-sildenafil-in-rats
#15
Eyad Mallah, Soadad Saleh, Walid Abu Rayyan, Wael Abu Dayyih, Feras Darwish Elhajji, Mohammed Mima, Riad Awad, Tawfiq Arafat
OBJECTIVES: A drug like Sildenafil is commonly used for the treatment of erectile dysfunction. Eruca sativa is known as a garden plant used in folk medicine to enhance the sexual desire in males. Nevertheless, the interaction of Sildenafil and Eruca sativa was not studied. In the current study, we aimed to examine the influence of Eruca sativa on Sildenafil pharmacokinetics in rats. STUDY DESIGN: A crossover experiment with washout period of two weeks was conducted...
August 5, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28859233/imaging-for-the-diagnosis-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#16
REVIEW
Lewis R Roberts, Claude B Sirlin, Feras Zaiem, Jehad Almasri, Larry J Prokop, Julie Heimbach, M Hassan Murad, Khaled Mohammed
Multiphasic computed tomography (CT) and magnetic resonance imaging (MRI) are both used for non-invasive diagnosis of hepatocellular carcinoma (HCC) in patients with cirrhosis. To determine if there is a relative diagnostic benefit of one over the other, we synthesized evidence regarding the relative performances of CT, extracellular-contrast-enhanced-MRI, and gadoxetate-enhanced-MRI for diagnosis of HCC in patients with cirrhosis. We also assessed whether liver biopsy versus follow-up with the same versus alternative imaging is best for CT- or MRI-indeterminate liver nodules in patients with cirrhosis...
August 31, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28859222/therapies-for-patients-with-hepatocellular-carcinoma-awaiting-for-liver-transplantation-a-systematic-review-and-meta-analysis
#17
REVIEW
Laura Kulik, Julie K Heimbach, Feras Zaiem, Jehad Almasri, Larry J Prokop, Zhen Wang, M Hassan Murad, Khaled Mohammed
Patients with hepatocellular carcinoma (HCC) who are listed for liver transplantation are often treated while on the waiting list with loco-regional therapy (LRT) which is aimed at either preventing progression of HCC or reducing themeasurable disease burden of HCC in order to receive increased allocation priority. We aimed to synthesize evidence regarding the effectiveness of LRT in the management of patients with HCC who were on the liver transplant waitlist. We conducted a comprehensive search of multiple databases from 1996 to April 25, 2016, for studies that enrolled adults with cirrhosis awaiting liver transplantation and treated with bridging or down-staging therapies before liver transplantation...
August 31, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28859190/comparative-effectiveness-and-safety-of-cognitive-behavioral-therapy-and-pharmacotherapy-for-childhood-anxiety-disorders-a-systematic-review-and-meta-analysis
#18
Zhen Wang, Stephen P H Whiteside, Leslie Sim, Wigdan Farah, Allison S Morrow, Mouaz Alsawas, Patricia Barrionuevo, Mouaffaa Tello, Noor Asi, Bradley Beuschel, Lubna Daraz, Jehad Almasri, Feras Zaiem, Laura Larrea-Mantilla, Oscar J Ponce, Annie LeBlanc, Larry J Prokop, Mohammad Hassan Murad
Importance: Childhood anxiety is common. Multiple treatment options are available, but existing guidelines provide inconsistent advice on which treatment to use. Objectives: To evaluate the comparative effectiveness and adverse events of cognitive behavioral therapy (CBT) and pharmacotherapy for childhood anxiety disorders. Data Sources: We searched MEDLINE, EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and SciVerse Scopus from database inception through February 1, 2017...
August 31, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28857776/cha2ds2-vasc-score-and-exercise-capacity-of-patients-with-coronary-artery-disease-participating-in-cardiac-rehabilitation-programs
#19
Feras Haskiah, Yacov Shacham, Saar Minha, Zach Rozenbaum, David Pereg
BACKGROUND: Exercise based cardiac rehabilitation improves prognosis and quality of life in patients with coronary artery disease. We aimed to investigate whether the CHA2DS2-VASc score may be a predictor of improvement in exercise capacity in acute coronary syndrome (ACS) patients participating in a cardiac rehabilitation program. METHODS: Included were patients following a hospital admission due to ACS and were subsequently referred for an exercise based cardiac rehabilitation during 2010-2015...
August 29, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28840047/complete-laparoscopic-extirpation-of-a-giant-ovarian-cyst-in-an-adolescent
#20
Saeed Baradwan, Feras Sendy, Sameer Sendy
The giant ovarian serous cystadenoma is a rare finding and often benign. The use of the laparoscopic approach versus open approach for the management of huge ovarian cysts is controversial. We report a case of a 27-year-old woman with a history of increasing abdominal girth over a period of two years along with radiological investigations revealed a large tumor arising from the right ovary treated by complete laparoscopic extirpation of a giant ovarian cyst. The complete laparoscopic approach for huge cyst is a feasible treatment when having a normal tumor marker profile and benign imaging appearance...
2017: Case Reports in Obstetrics and Gynecology
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