Jinhong Dai, Nicholas G Fischer, Joseph R Rahimi, Hongning Wang, Chaoming Hu, Wener Chen, Yifan Lin, Ting Sang, Hooi Pin Chew, Liang Kong, Conrado Aparicio, Zhou Ye, Shengbin Huang
Bone regeneration remains a major clinical challenge, especially when infection necessitates prolonged antibiotic treatment. This study presents a membrane composed of self-assembled and interpenetrating GL13K, an antimicrobial peptide (AMP) derived from a salivary protein, in a collagen membrane for antimicrobial activity and enhanced bone regeneration. Commercially available collagen membranes were immersed in GL13K solution, and self-assembly was initiated by raising the solution pH to synthesize the multifunctional membrane called COL-GL...
April 8, 2024: International Journal of Biological Macromolecules