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https://www.readbyqxmd.com/read/28453823/a-flowchart-for-building-evidence-based-care-bundles-in-intensive-care-based-on-a-systematic-review
#1
Marjon Borgert, Jan Binnekade, Frederique Paulus, Astrid Goossens, Dave Dongelmans
Purpose: The Institute for Healthcare Improvement is the founder of the care bundled approach and described the methods used on how to develop care bundles. However, other useful methods are published as well. In this systematic review, we identified what different methods were used to design care bundles in intensive care units. The results were used to build a comprehensive flowchart to guide through the care bundle design process. Data sources: Electronic databases were searched for eligible studies in PubMed, EMBASE and CINAHL from January 2001 to August 2014...
April 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28453433/diagnostic-accuracy-of-selective-3-t-mr-neurography-guided-retroperitoneal-genitofemoral-nerve-blocks-for-the-diagnosis-of-genitofemoral-neuralgia
#2
Jan Fritz, A Lee Dellon, Eric H Williams, Gedge D Rosson, Allan J Belzberg, Frederick E Eckhauser
Purpose To determine if 3-T magnetic resonance (MR) neurography-guided retroperitoneal genitofemoral nerve (GFN) blocks are safe and effective for the diagnosis of genitofemoral neuralgia. Materials and Methods Following institutional review board approval and informed consent, 26 subjects (16 men, 10 women; mean age, 42 years [range, 24-78 years]; mean body mass index, 28 kg/m(2) [range, 20-35 kg/m(2)]) with intractable groin pain were included. By using a 3-T MR imaging system, intermediate-weighted turbo spin-echo pulse sequences, and MR-conditional needles, diagnostic MR neurography-guided GFN blocks were performed in the retroperitoneum...
April 28, 2017: Radiology
https://www.readbyqxmd.com/read/28453305/a-clinician-guide-to-altitude-training-for-optimal-endurance-exercise-performance-at-sea-level
#3
Keren Constantini, Daniel P Wilhite, Robert F Chapman
Constantini, Keren, Daniel P. Wilhite, and Robert F. Chapman. A clinician guide to altitude training for optimal endurance exercise performance at sea level. High Alt Med Biol 00:000-000, 2017.-For well over 50 years, endurance athletes have been utilizing altitude training in an effort to enhance performance in sea level competition. This brief review will offer the clinician a series of evidence-based best-practice guidelines on prealtitude and altitude training considerations, which can ultimately maximize performance improvement outcomes...
April 28, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28449510/chondromatous-hamartoma-of-cervical-esophagus-a-case-report-and-literature-review
#4
Chong Zhang, Jinming Xu, Zhitian Wang, Zhehao He, Hanjin Yang, Jian Hu
Esophageal chondromatous hamartomas are very rare tumors, characterized by proliferating hyaline cartilage cells. We described the case of a 64-year-old woman, with a progressive foreign body sensation in the laryngopharynx caused by an intraluminal pedicled mass. Transcervical esophagectomy was performed and intraoperative biopsy revealed the mass was a cervical esophageal chondromatous hamartoma. The patient's postoperative course was uneventful and she recovered well. A review of the literature was conducted, and the symptoms, locations, histopathology findings, treatment methods and follow up results of esophageal hamartoma cases were summarized...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449340/identifying-the-optimal-strategy-for-screening-of-advanced-colorectal-neoplasia
#5
Yoon Suk Jung, Chan Hyuk Park, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND AND AIM: To guide selection of optimal screening strategies for advanced colorectal neoplasia (ACRN), we evaluated the screening performances of sigmoidoscopy, fecal immunochemical test (FIT), and the Asia-Pacific Colorectal Screening (APCS) system, as well as combinations of these techniques. METHODS: We reviewed the records of participants who had undergone a colonoscopy and FIT as part of a comprehensive health-screening program. Results of sigmoidoscopy were estimated from lesions under colonoscopic examination...
May 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28449236/discovery-of-lhrh-and-development-of-lhrh-analogs-for-prostate-cancer-treatment
#6
Andrew V Schally, Norman L Block, Ferenc G Rick
The discovery, isolation, elucidation of structure, synthesis, and initial testing of the neuropeptide hypothalamic luteinizing hormone-releasing hormone (LHRH), which regulates reproduction, is briefly described. The design, synthesis, and experimental and clinical testing of agonistic analogs of LHRH is extensively reviewed focusing on the development of new methods for the treatment of prostate cancer. Subsequent development of antagonistic analogs of LHRH is then faithfully recounted with special emphasis on therapy of prostate cancer and BPH...
April 27, 2017: Prostate
https://www.readbyqxmd.com/read/28449101/synthetic-biology-approaches-for-the-production-of-plant-metabolites-in-unicellular-organisms
#7
Tessa Moses, Payam Mehrshahi, Alison G Smith, Alain Goossens
Synthetic biology is the repurposing of biological systems for novel objectives and applications. Through the co-ordinated and balanced expression of genes, both native and those introduced from other organisms, resources within an industrial chassis can be siphoned for the commercial production of high-value commodities. This developing interdisciplinary field has the potential to revolutionize natural product discovery from higher plants, by providing a diverse array of tools, technologies, and strategies for exploring the large chemically complex space of plant natural products using unicellular organisms...
April 25, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28449088/clinical-manifestations-of-scrub-typhus
#8
Senaka Rajapakse, Praveen Weeratunga, Sriharan Sivayoganathan, Sumadhya Deepika Fernando
The mite-borne rickettsial zoonosis scrub typhus is widely prevalent in parts of Southeast and Far East Asia, and northern Australia. The disease is an acute febrile illness, associated with rash and often an eschar, which responds dramatically to treatment with antibiotics. In some cases it results in a serious illness leading to multiple organ involvement and death. The disease manifestations are thought to result from a systemic vasculitis, caused by both direct effects of the organisms as well as an exaggerated immune response, although little is understood about its pathogenesis...
April 25, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28448965/neuroprotective-treatments-after-perinatal-hypoxic-ischemic-brain-injury-evaluated-with-magnetic-resonance-spectroscopy
#9
Hester Rijkje Berger, Eva Brekke, Marius Widerøe, Tora Sund Morken
Perinatal hypoxic-ischemic brain injury is a major health problem. Adjuvant treatments that improve the neuroprotective effect of the current treatment, therapeutic hypothermia, are urgently needed. The growing knowledge about the complex pathophysiology of hypoxia-ischemia (HI) has led to the discovery of several important targets for neuroprotection. Early interventions should focus on the preservation of energy metabolism, the reduction of glutamate excitotoxicity and oxidative stress, the maintenance of calcium homeostasis, and the prevention of apoptosis...
April 28, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28448914/reconciling-agriculture-and-stream-restoration-in-europe-a-review-relating-to-the-eu-water-framework-directive
#10
REVIEW
H M Flávio, P Ferreira, N Formigo, J C Svendsen
Agriculture is widespread across the EU and has caused considerable impacts on freshwater ecosystems. To revert the degradation caused to streams and rivers, research and restoration efforts have been developed to recover ecosystem functions and services, with the European Water Framework Directive (WFD) playing a significant role in strengthening the progress. Analysing recent peer-reviewed European literature (2009-2016), this review explores 1) the conflicts and difficulties faced when restoring agriculturally impacted streams, 2) the aspects relevant to effectively reconcile agricultural land uses and healthy riverine ecosystems and 3) the effects and potential shortcomings of the first WFD management cycle...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448645/estimating-survival-after-salvage-surgery-for-recurrent-oral-cavity-cancer
#11
Samantha Tam, Rakhna Araslanova, Tsu-Hui Hubert Low, Andrew Warner, John Yoo, Kevin Fung, S Danielle MacNeil, David A Palma, Anthony C Nichols
Importance: Locoregional recurrence of oral cavity squamous cell carcinoma (OCSCC) continues to be a life-threatening and difficult clinical situation. Salvage surgery can result in significant morbidities, and survival following recurrence is poor. Objective: To outline prognostic factors influencing overall survival (OS) following salvage surgery for OCSCC to guide management of treatment for patients with locoregionally recurrent disease. Design, Setting, and Participants: The medical records of 293 patients presenting to the London Health Sciences Center with locoregionally recurrent OCSCC between October 5, 1999, and May 2, 2011, were retrospectively reviewed...
April 27, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28447902/reporting-results-of-molecular-tests-a-retrospective-examination-of-braf-mutation-reporting
#12
Amanda L Treece, Margaret L Gulley, Patricia Vasalos, Cherie Paquette, Neal I Lindeman, Lawrence J Jennings, Angela N Bartley
CONTEXT: - With enormous growth in the field of molecular pathology, the reporting of results gleaned from this testing is essential to guide patient care. OBJECTIVE: - To examine molecular reports from laboratories participating in proficiency testing for required elements to convey molecular laboratory test results to clinicians and patients. DESIGN: - Molecular laboratories participating in the College of American Pathologists (CAP) proficiency testing program for BRAF mutation analysis were solicited to submit examples of final reports from 2 separate proficiency testing reporting cycles...
May 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28447823/the-promise-of-demand-side-employer-based-strategies-to-increase-employment-rates-for-people-living-with-serious-mental-illnesses
#13
Jonathan Delman, Lynn Kovich, Sara Burke, Kevin Martone
OBJECTIVE: This article describes current and promising demand-side strategies to increase job retention and employment rates of people living with serious mental illnesses. The article raises awareness of the potential impact of demand side strategies and generates considerations to implement and evaluate these strategies. METHOD: Information is drawn from peer reviewed research, policy articles and documents, and the authors' direct experiences. RESULTS: Employees with serious mental illnesses struggle to retain jobs due to workplace stigma, difficulty accessing reasonable accommodations, and noneligibility for health benefits...
April 27, 2017: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/28447671/the-scaffold-microenvironment-for-stem-cell-based-bone-tissue-engineering
#14
REVIEW
Zhichao Hao, Zhenhua Song, Jun Huang, Keqing Huang, Amanda Panetta, Zhipeng Gu, Jun Wu
Bone tissue engineering uses the principles and methods of engineering and life sciences to study bone structure, function and growth mechanism for the purposes of repairing, maintaining and improving damaged bone tissue. Scaffolds not only provide structural support for stem cells in cell adhesion and proliferation and bone formation, but also serve as a microenvironment for guiding stem cell differentiation and tissue regeneration and for controlling tissue structure. This review presents the research status of the scaffold microenvironment for bone-related stem cells based on bone tissue engineering...
April 27, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28447662/expert-consensus-document-echocardiography-and-lung-ultrasonography-for-the-assessment-and-management-of-acute-heart-failure
#15
REVIEW
Susanna Price, Elke Platz, Louise Cullen, Guido Tavazzi, Michael Christ, Martin R Cowie, Alan S Maisel, Josep Masip, Oscar Miro, John J McMurray, W Frank Peacock, F Javier Martin-Sanchez, Salvatore Di Somma, Hector Bueno, Uwe Zeymer, Christian Mueller
Echocardiography is increasingly recommended for the diagnosis and assessment of patients with severe cardiac disease, including acute heart failure. Although previously considered to be within the realm of cardiologists, the development of ultrasonography technology has led to the adoption of echocardiography by acute care clinicians across a range of specialties. Data from echocardiography and lung ultrasonography can be used to improve diagnostic accuracy, guide and monitor the response to interventions, and communicate important prognostic information in patients with acute heart failure...
April 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28447467/perinatal-and-infant-mental-health-in-australia-moving-forward-towards-real-prevention-and-early-intervention-can-we-do-it
#16
Anne E Sved Williams
OBJECTIVES: Australia has been at the forefront of appropriate early intervention. Prevention of mental illness in infants by early identification and intervention in the mental health of their mothers has stalled since the cessation of funding through the National Perinatal Depression Initiative (NPDI, 2009-2015). Whilst screening for maternal mental illness has been widely implemented throughout Australia during the last two decades, services are now diminishing and great opportunities to ride the crest of a wave for appropriate mental illness intervention are receding...
April 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28447424/does-morphology-matter-in-2017-an-approach-to-morphologic-clues-in-non-neoplastic-blood-and-bone-marrow-disorders
#17
REVIEW
D S Chabot-Richards, K Foucar
Numerous non-neoplastic and neoplastic conditions manifest with distinctive features in blood. Although automated complete blood count (CBC) data are essential, CBC information alone is insufficient for diagnosis. Consequently, morphologic review of blood smears is still relevant in the era of sophisticated automated analyzer systems. Pathologist interpretation of the peripheral blood smear, in conjunction with CBC and clinical information, can provide rapid diagnostic information and guide cost-effective targeted laboratory testing...
May 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28447422/minimal-residual-disease-in-acute-myelogenous-leukemia
#18
REVIEW
N M Cruz, N Mencia-Trinchant, D C Hassane, M L Guzman
Treatment of acute myelogenous leukemia (AML) over the past four decades remains mostly unchanged and the prognosis for the majority of patients remains poor. Most of the significant advances that have been observed are in defining cytogenetic abnormalities, as well as the genetic and epigenetic profiles of AML patients. While new cytogenetic and genetic aberrations such as the FLT3-ITD and NPM1 mutations are able to guide prognosis for the majority of patients with AML, outcomes are still dismal and relapse rates remain high...
May 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28447416/microfluidics-in-flow-cytometry-and-related-techniques
#19
REVIEW
M C Béné
Technological advances in laboratory automation are now well understood and applied as they considerably improved the speed and robustness of haematological laboratory data, in the companion fields of blood analyzers and flow cytometry. Still rather confidential is the field of microfluidics, mostly confined so far to academic settings and research laboratories. The literature in the field of microfluidics is growing and applications in hematology range from cell counting to flow cytometry, cell sorting, or ex vivo testing...
May 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28447414/review-of-d-dimer-testing-good-bad-and-ugly
#20
REVIEW
L-A Linkins, S Takach Lapner
D-dimer assays are commonly used in clinical practice to exclude a diagnosis of deep vein thrombosis or pulmonary embolism. More recently, they have been also been used to guide patients with unprovoked venous thromboembolism (VTE) when faced with the decision to continue or stop anticoagulation after initial treatment is complete. D-dimer assays vary widely with respect to the antibody used, method of capture, instrumentation required, and calibration standard. These differences have an important influence on the operating characteristics of the assays...
May 2017: International Journal of Laboratory Hematology
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