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https://www.readbyqxmd.com/read/29474004/image-guided-surgery-in-cancer-a-strategy-to-reduce-incidence-of-positive-surgical-margins
#1
REVIEW
Kathryn R Tringale, John Pang, Quyen T Nguyen
Primary treatment for many solid cancers includes surgical excision or radiation therapy, with or without the use of adjuvant therapy. This can include the addition of radiation and chemotherapy after primary surgical therapy, or the addition of chemotherapy and salvage surgery to primary radiation therapy. Both primary therapies, surgery and radiation, require precise anatomic localization of tumor. If tumor is not targeted adequately with initial treatment, disease recurrence may ensue, and if targeting is too broad, unnecessary morbidity may occur to nearby structures or remaining normal tissue...
February 23, 2018: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/29473644/the-atrial-fibrillation-health-literacy-information-technology-system-pilot-assessment
#2
Jared W Magnani, Courtney L Schlusser, Everlyne Kimani, Bruce L Rollman, Michael K Paasche-Orlow, Timothy W Bickmore
Background: Atrial fibrillation (AF) is a highly prevalent heart rhythm condition that has significant associated morbidity and requires chronic treatment. Mobile health (mHealth) technologies have the potential to enhance multiple aspects of AF care, including education, monitoring of symptoms, and encouraging and tracking medication adherence. We have previously implemented and tested relational agents to improve outcomes in chronic disease and sought to develop a smartphone-based relational agent for improving patient-centered outcomes in AF...
July 2017: JMIR Cardio
https://www.readbyqxmd.com/read/29473500/crispr-cas-system-as-a-genome-engineering-platform-applications-in-biomedicine-and-biotechnology
#3
Atieh Hashemi
Genome editing mediated by clustered regularly interspaced palindromic repeats (CRISPR) and its associated proteins (Cas) has recently been considered to be used as efficient, rapid and site-specific tools in the modification of endogenous genes in biomedically important cell types and whole organisms. It has become a predictable and precise method of choice for genome engineering by specifying a 20-nt targeting sequence within its guide RNA. First, this review aims to describe the biology of CRISPR system...
February 20, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29473440/goal-setting-in-paediatric-rehabilitation-for-children-with-motor-disabilities-a-scoping-review
#4
Lesley Pritchard-Wiart, Shanon K Phelan
OBJECTIVES: The three objectives of this scoping review were to (1) identify key conceptual/theoretical frameworks and the extent to which they are used to inform goal setting related to rehabilitation goal setting with children with motor disabilities, (2) describe research that has evaluated goal setting processes and outcomes, and (3) summarize the purposes of goal setting described in paediatric rehabilitation literature. METHODS: The scoping review process described by Arksey and O'Malley was used to guide article selection and data extraction...
February 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29473258/treating-women-with-opioid-use-disorder-during-pregnancy-in-appalachia-initial-neonatal-outcomes-following-buprenorphine-naloxone-exposure
#5
Linda Nguyen, Laura R Lander, Kevin E O'Grady, Patrick J Marshalek, Adrienne Schmidt, Audra K Kelly, Hendrée E Jones
BACKGROUND AND OBJECTIVES: Rising concerns regarding diversion and misuse of mono-buprenorphine for treatment of pregnant women with opioid use disorders have sparked interest in the use of buprenorphine + naloxone to reduce misuse and diversion rates. Examined the relationship of prenatal buprenorphine + naloxone exposure to neonatal outcomes. METHODS: This is a retrospective chart review of 26 mother infant dyads in comprehensive medication-assisted treatment with buprenorphine + naloxone during pregnancy...
February 23, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29473160/deciphering-the-roles-of-foxo1-in-human-neoplasms
#6
REVIEW
Shuai Jiang, Tian Li, Zhi Yang, Wei Hu, Yang Yang
Neoplasms constitute an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of FOXO1 in neoplasms. This review may serve as a guide for future research and identify FOXO1 as a potent therapeutic target in neoplasms. This article is protected by copyright. All rights reserved...
February 23, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29472851/self-active-relaxation-therapy-sart-and-self-regulation-a-comprehensive-review-and-comparison-of-the-japanese-body-movement-approach
#7
REVIEW
Russell S Kabir, Yutaka Haramaki, Hyeyoung Ki, Hiroyuki Ohno
Relaxation programs are known for their versatility, cost-effectiveness, and ability to help people obtain skills to regulate their mental states and promote and maintain health. Self-Active Relaxation Therapy (SART) is a body-oriented approach to psychological rehabilitation that grew out of the suite of movement tasks developed in the Japanese psychotherapy known as Dohsa-hou , or the body movement method. The program for SART is designed to stretch, twist, and release areas of the upper, lower, and whole body through a set of movements which are guided by the practitioner and performed "self-actively" by the client to empower them to learn to recognize points of tension in the body and act on their own to achieve a relaxed state...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29472313/luminal-a-breast-cancer-and-molecular-assays-a-review
#8
REVIEW
Jennifer J Gao, Sandra M Swain
PURPOSE: Chemotherapy has been the historical mainstay of treatment for patients with breast cancer, with immunohistochemical markers and tumor characteristics driving treatment decisions. The discovery of different intrinsic subtypes of breast cancer has advanced the understanding of breast cancer, with gene-based assays shedding further light on tumor behavior and response to treatment. DESIGN: This review focuses on the landscape of the luminal A subtype, its definition based on immunohistochemistry (IHC) and gene assays, the prognostic and predictive value of these assays, guideline recommendations, and treatment implications...
February 22, 2018: Oncologist
https://www.readbyqxmd.com/read/29472174/peer-based-social-media-features-in-behavior-change-interventions-systematic-review
#9
REVIEW
Sheik Mohammad Roushdat Ally Elaheebocus, Mark Weal, Leanne Morrison, Lucy Yardley
BACKGROUND: Incorporating social media features into digital behavior change interventions (DBCIs) has the potential to contribute positively to their success. However, the lack of clear design principles to describe and guide the use of these features in behavioral interventions limits cross-study comparisons of their uses and effects. OBJECTIVE: The aim of this study was to provide a systematic review of DBCIs targeting modifiable behavioral risk factors that have included social media features as part of their intervention infrastructure...
February 22, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29471998/baby-on-board-managing-occupational-radiation-exposure-during-pregnancy
#10
M Victoria Marx
This article reviews the issue of occupational radiation exposure as a deterrent to recruitment of women into the field of interventional radiology and provides the reader with three strategies to optimize radiation protection during fluoroscopically guided procedures. These include personal protective shielding, use of ancillary shielding, and techniques that limit fluoroscopy x-ray tube output. When optimal radiation safety practices are implemented as the norm in the IR suite, very little extra needs to be done to ensure that fetal dose of a pregnant interventionalist is negligible...
March 2018: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/29471995/should-we-keep-the-lead-in-the-aprons
#11
Gabriel Bartal, Anna M Sailer, Eliseo Vano
Medical staff should not be exposed to the primary X-ray beam during fluoroscopy-guided interventional procedures (FGIP). The main source of staff exposure is scatter radiation from the patient, which can be significant. Although many aspects of X-ray exposure to the patient as well as occupational exposure to interventional radiologists and other staff are strongly regulated and monitored in most countries, it is surprising how loosely the labeling and testing of the protective aprons is regulated. Interventional radiologists (IRs) have to be experts in interventional radiology as well as in basic facts regarding ways to provide a satisfactory level of protection from occupational exposure...
March 2018: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/29471791/systemic-fluoroquinolone-prescriptions-for-hospitalized-children-in-belgium-results-of-a-multicenter-retrospective-drug-utilization-study
#12
Kevin Meesters, Reiner Mauel, Evelyn Dhont, Johan Vande Walle, Pauline De Bruyne
BACKGROUND: Fluoroquinolones (FQ) are increasingly prescribed for children, despite being labeled for only a limited number of labeled pediatric indications. In this multicenter retrospective drug utilization study, we analyzed indications for systemic FQ prescriptions in hospitalized children and the appropriateness of the prescribed dose. METHODS: Using data obtained from electronic medical files, the study included all children who received a systemic FQ prescription in two Belgian university children's hospitals between 2010 and 2013...
February 23, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29471619/post-surgical-recurrence-of-hcc-along-resection-margin-treated-by-percutaneous-us-guided-ablation
#13
Marco Calandri, Carlo Gazzera, Steven Yevich, Katia Lapenna, Maria Marenco, Andrea Veltri, Gianluca Paraluppi, Paolo Fonio
BACKGROUND: To evaluate the safety and efficacy of percutaneous ablation for HCC hepatic recurrence along surgical resection margins to achieve complete cure or bridge for additional treatment. No current recommendations exist for these lesions. METHODS: Retrospective review of post-surgical recurrent HCC located along surgical margins treated by percutaneous ultrasound-guided ablation from 2006-2014. Ablation was performed by radiofrequency ablation (RFA) or percutaneous ethanol injection (PEI), selected for recurrence in proximity to extrahepatic organs...
February 21, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29470969/neuromodulation-of-attention
#14
REVIEW
Alexander Thiele, Mark A Bellgrove
Attention is critical to high-level cognition and attention deficits are a hallmark of neurologic and neuropsychiatric disorders. Although years of research indicates that distinct neuromodulators influence attentional control, a mechanistic account that traverses levels of analysis (cells, circuits, behavior) is missing. However, such an account is critical to guide the development of next-generation pharmacotherapies aimed at forestalling or remediating the global burden associated with disorders of attention...
February 21, 2018: Neuron
https://www.readbyqxmd.com/read/29470703/guide-for-health-professionals-addressing-oral-care-for-individuals-in-oncological-treatment-based-on-scientific-evidence
#15
Caroline Gomes Carvalho, João Batista Medeiros-Filho, Meire Coelho Ferreira
OBJECTIVE: Oncological treatment can cause changes in the oral cavity compromising oral functions. The aim of the study was, based on a systematic review, to draft a guide directed at the team of health professionals involved in the oral care of oncological patients. METHODS: A systematic search of the literature was performed for articles published between 2000 and April 2017. Searches were made of electronic databases and hand search. The inclusion criteria were systematic reviews of randomized clinical trials (RCTs) and RCTs published in English, involving pediatric and adult oncological patients and focused on the prevention and treatment of oral complications as well as studies addressing the maintenance of oral health...
February 22, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29470303/clues-in-histopathological-diagnosis-of-panniculitis
#16
Mar Llamas Velasco, Yosmar Carolina Pérez-Gónzalez, Werner Kempf, Bruno Emilio Paredes, Lorenzo Cerroni, María Teresa Fernández Figueras
BACKGROUND: Panniculitides comprise a group of heterogeneous inflammatory diseases. Nevertheless, histopathological study along with clinicopathological correlation usually led to a specific diagnosis. In most textbooks, the first step in the diagnosis is to classify them as mostly septal or lobular depending on where the inflammatory infiltrate is located. The second step is deciding if vasculitis is present or not. Finally, the third step is further characterizing the inflammatory infiltrate...
March 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29470291/recurrent-abdominal-pain-in-children-summary-evidence-from-3-systematic-reviews-of-treatment-effectiveness
#17
Rebecca A Abbott, Alice E Martin, Tamsin V Newlove-Delgado, Alison Bethel, Rebecca S Whear, Jo Thompson Coon, Stuart Logan
OBJECTIVES: Between 4% and 25% of school-aged children complain of recurrent abdominal pain (RAP) severe enough to interfere with their daily activities. METHODS: We carried out a systematic review of randomised controlled trials (RCTs) in eleven databases and 2 trials registries from inception to June 2016. An update search was run in November 2017. All screening was performed by 2 independent reviewers. Included studies were appraised using the Cochrane risk of bias tool and the evidence assessed using GRADE...
February 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29470154/unipedal-diagnostic-lymphangiography-followed-by-sequential-ct-examinations-in-patients-with-idiopathic-chyluria-a-retrospective-study
#18
Jian Dong, Jianfeng Xin, Wenbin Shen, Xiaobai Chen, Tingguo Wen, Chunyan Zhang, Rengui Wang
OBJECTIVE: The objective of our study was to investigate the clinical value of diagnostic lymphangiography followed by sequential CT examinations in patients with idiopathic chyluria. MATERIALS AND METHODS: Thirty-six patients with idiopathic chyluria underwent unipedal diagnostic lymphangiography and then underwent sequential CT examinations. The examinations were reviewed separately by two radiologists. Abnormal distribution of contrast medium, lymphourinary leakages, and retrograde flow were noted, and the range and distribution of lymphatic vessel lesions were recorded...
February 22, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29469670/role-of-mirnas-in-treatment-response-and-toxicity-of-childhood-acute-lymphoblastic-leukemia
#19
Maitane Umerez, Susana Garcia-Obregon, Idoia Martin-Guerrero, Itziar Astigarraga, Angela Gutierrez-Camino, Africa Garcia-Orad
Childhood acute lymphoblastic leukemia survival rates have increased remarkably during last decades due, in part, to intensive treatment protocols. However, therapy resistance and toxicity are still two important barriers to survival. In this context, pharmacoepigenetics arises as a tool to identify new predictive markers, required to guide clinicians on risk stratification and dose individualization. The present study reviews current evidence about miRNA implication on childhood acute lymphoblastic leukemia therapy resistance and toxicity...
February 22, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29468964/recent-advances-in-antibacterial-antiprotozoal-and-antifungal-trends-of-eurycoma-longifolia-a-review-of-therapeutic-implications-and-future-prospects
#20
Hnin Ei Thu, Zahid Hussain, Isa Naina Mohamed, Ahmad Nazrun Shuid
BACKGROUND: Eurycoma longifolia (E. longifolia) has gained widespread recognition due to its versatile pharmacological activities including aphrodisiac, anticancer, antimicrobial, antioxidant, anti-inflammatory, anxiolytic, anti-diabetic, ergogenic, insecticidal, anti-rheumatism, bone protection, and anti-ulcer effects. OBJECTIVE: This review was aimed to critically overview the literature and summarizes the antibacterial, antiprotozoal, and antifungal trends of E...
February 19, 2018: Current Drug Targets
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