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https://www.readbyqxmd.com/read/28239489/insights-from-molecular-dynamics-simulations-for-computational-protein-design
#1
Matthew Carter Childers, Valerie Daggett
A grand challenge in the field of structural biology is to design and engineer proteins that exhibit targeted functions. Although much success on this front has been achieved, design success rates remain low, an ever-present reminder of our limited understanding of the relationship between amino acid sequences and the structures they adopt. In addition to experimental techniques and rational design strategies, computational methods have been employed to aid in the design and engineering of proteins. Molecular dynamics (MD) is one such method that simulates the motions of proteins according to classical dynamics...
February 1, 2017: Molecular Systems Design & Engineering
https://www.readbyqxmd.com/read/28239303/structure-and-functioning-of-dryland-ecosystems-in-a-changing-world
#2
Fernando T Maestre, David J Eldridge, Santiago Soliveres, Sonia Kéfi, Manuel Delgado-Baquerizo, Matthew A Bowker, Pablo García-Palacios, Juan Gaitán, Antonio Gallardo, Roberto Lázaro, Miguel Berdugo
Understanding how drylands respond to ongoing environmental change is extremely important for global sustainability. Here we review how biotic attributes, climate, grazing pressure, land cover change and nitrogen deposition affect the functioning of drylands at multiple spatial scales. Our synthesis highlights the importance of biotic attributes (e.g. species richness) in maintaining fundamental ecosystem processes such as primary productivity, illustrate how N deposition and grazing pressure are impacting ecosystem functioning in drylands worldwide, and highlight the importance of the traits of woody species as drivers of their expansion in former grasslands...
November 2016: Annual Review of Ecology, Evolution, and Systematics
https://www.readbyqxmd.com/read/28238993/perceived-barriers-and-facilitators-to-health-care-utilization-in-the-united-states-for-transgender-people-a-review-of-recent-literature
#3
Justin E Lerner, Gabriel Robles
Transgender people face numerous barriers when utilizing health care in the United States. The current study sought to highlight transgender consumer perspectives in order to present theoretically informed, concrete recommendations for increasing transgender health care utilization. The search yielded several prominent themes associated with barriers to health care for transgender people: 1) provider lack of knowledge concerning transgender identity issues and transgender health issues, 2) transgender patients' previous negative experiences with the health care system or anticipation of these experiences, 3) transgender patients' inability to pay for health care services, and 4) health care provider refusal to provide health care services to transgender people...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28238948/mechanisms-of-embryonic-stomach-development
#4
REVIEW
Kyle W McCracken, James M Wells
The stomach is a digestive organ that has important roles in human physiology and pathophysiology. The developmental origin of the stomach is the embryonic foregut, which also gives rise a number of other structures. There are several signaling pathways and transcription factors that are known to regulate stomach development at different stages, including foregut patterning, stomach specification, and gastric regionalization. These developmental events have important implications in later homeostasis and disease in the adult stomach...
February 23, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28238894/a-narrative-review-of-social-media-and-game-based-nutrition-interventions-targeted-at-young-adults
#5
Monica Nour, Sin Hang Yeung, Stephanie Partridge, Margaret Allman-Farinelli
The increased popularity of social media and mobile gaming among young adults provides an opportunity for innovative nutrition programs. This review evaluated the efficacy of these strategies in interventions targeted at 18- to 35-year-olds. The protocol was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Ten scientific databases, information technology conference proceedings, and gray literature were searched. Two reviewers conducted screening, data extraction, and quality assessments...
February 23, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28238682/association-between-dietary-pattern-and-cardiometabolic-risk-in-children-and-adolescents-a-systematic-review
#6
REVIEW
Naruna Pereira Rocha, Luana Cupertino Milagres, Giana Zarbato Longo, Andréia Queiroz Ribeiro, Juliana Farias de Novaes
OBJECTIVE: To evaluate the association between dietary patterns and cardiometabolic risk factors in children and adolescents. DATA SOURCE: This article followed the recommendations of PRISMA, which aims to guide review publications in the health area. The article search strategy included searches in the electronic databases MEDLINE via PubMed, Scopus, and LILACS. There was no date limitation for publications. The descriptors were used in English according to MeSH and in Portuguese according to DeCS...
February 23, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28238460/-irritable-bowel-syndrome-with-constipation-and-functional-constipation-in-adults-treatment-part-2-of-2
#7
F Mearin, C Ciriza, M Mínguez, E Rey, J J Mascort, E Peña, P Cañones, J Júdez
In this Clinical practice guide we examine the diagnostic and therapeutic management of adult patients with constipation and abdominal discomfort, at the confluence of the spectrum of irritable bowel syndrome and functional constipation. Both fall within the framework of functional intestinal disorders and have major personal, health and social impact, altering the quality of life of the patients affected. The former is a subtype of irritable bowel syndrome in which constipation and altered bowel habit predominate, often along with recurring abdominal pain, bloating and abdominal distension...
February 23, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28238390/electro-clinical-etiological-associations-of-epilepsia-partialis-continua-in-57-chinese-children
#8
Hui Li, Jiao Xue, Ping Qian, Yuehua Zhang, Xinhua Bao, Xiaoyan Liu, Zhixian Yang
OBJECTIVE: Epilepsia partialis continua (EPC) was one type of focal status epilepticus. The aim of this study was to analyze the clinical and electroencephalography (EEG) characteristics, and outcome of 57 child-onset patients with EPC according to different etiologies, and further explore the electro-clinical-etiological associations. METHODS: We retrospectively reviewed 57 children diagnosed with EPC in our department over last ten years. Etiology, clinical and EEG data, and outcome were categorized and analyzed...
February 18, 2017: Brain & Development
https://www.readbyqxmd.com/read/28238165/challenges-in-assessing-personality-of-individuals-with-gender-dysphoria-with-the-swap-200
#9
REVIEW
V Lingiardi, G Giovanardi
BACKGROUND: Personality assessment can be useful to better understand the complexity of transgender and transsexual people. In particular, the Shedler Westen Assessment Procedure-200 (SWAP-200) is a measure that provides an accurate dimensional evaluation of personality. When assessing gender non-conforming people, however, clinicians can encounter some difficulties in giving appropriate ratings to all the items. PURPOSE OF THE REVIEW: A brief guide to the use of SWAP-200 with transgender patients is provided, taking into account three areas of psychological functioning: identity, relationships and sexuality...
February 25, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28238033/clinical-and-multiparametric-mri-signatures-of-granulomatous-prostatitis
#10
Soroush Rais-Bahrami, Jeffrey W Nix, Baris Turkbey, Jason A Pietryga, Rupan Sanyal, John V Thomas, Jennifer B Gordetsky
PURPOSE: The purpose of the study is to differentiate granulomatous prostatitis (GP) from high-grade prostate cancer (PCa) based on clinical findings and imaging characteristics on multiparametric MRI (MP-MRI). METHODS: Pathology from patients undergoing MRI/US fusion-guided prostate biopsies between 2014 and 2015 was reviewed. Five patients with biopsy proven GP were identified as well as 15 patients with biopsy-proven Gleason score ≥4 + 3 = 7 PCa. Patients were matched for age, serum PSA level, and prebiopsy-assigned MP-MRI cancer suspicion scores...
February 25, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28238017/imaging-findings-of-anterior-hip-dislocations
#11
REVIEW
Kyle Pfeifer, Michael Leslie, Kirsten Menn, Andrew Haims
Anterior hip dislocations are rare orthopedic emergencies resulting from high-energy trauma and have unique imaging characteristics on radiography, computed tomography (CT), and magnetic resonance imaging (MRI). Imaging findings on CT and MRI allow for the prompt recognition and classification of anterior hip dislocations, which guides patient management and reduces complications. The purpose of this article is to review imaging findings of anterior hip dislocations, specifically focusing on CT and MRI.
February 25, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28237770/the-reliability-of-physical-examination-tests-for-the-clinical-assessment-of-scapular-dyskinesis-in-subjects-with-shoulder-complaints-a-systematic-review
#12
REVIEW
Toni Lange, Filip Struyf, Jochen Schmitt, Jörg Lützner, Christian Kopkow
STUDY DESIGN: Systematic review. OBJECTIVES: The aim of this systematic review was to summarize and evaluate intra- and interrater reliability research of physical examination tests used for the assessment of scapular dyskinesis. BACKGROUND: Scapular dyskinesis, defined as alteration of normal scapular kinematics, is described as a non-specific response to different shoulder pathologies. METHODS: A systematic literature search was conducted in MEDLINE, EMBASE, AMED and PEDro until March 20th, 2015...
November 3, 2016: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28237568/tibialis-posterior-tendon-dislocation-a-review-and-suggested-classification
#13
Andrew Strydom, Nikiforos Pandelis Saragas, Makgabo Tladi, Paulo Norberto Farria Ferrao
Tibialis posterior tendon dislocation is a rarely described entity that is easily missed, resulting in delayed diagnosis and treatment. A review of the English published data on the topic showed inconsistency in the reporting of injuries and surgical management techniques, leading us to describe a novel classification system to guide treatment and future reporting. We also describe a case of tibialis posterior tendon dislocation in a professional volleyball player and our surgical technique for correction, including retromalleolar groove deepening...
February 22, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28237357/integrating-social-context-into-comprehensive-shared-care-plans-a-scoping-review
#14
Suzanne S Sullivan, Francine Mistretta, Sabrina Casucci, Sharon Hewner
BACKGROUND: Failure to address social determinants of health (SDH) may contribute to the problem of readmissions in high-risk individuals. Comprehensive shared care plans (CSCP) may improve care continuity and health outcomes by communicating SDH risk factors across settings. PURPOSE: The purpose of this study to evaluate the state of knowledge for integrating SDH into a CSCP. Our scoping review of the literature considered 13,886 articles, of which seven met inclusion criteria...
February 3, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28237045/are-the-kids-alright-review-books-and-the-internet-as-the-most-common-study-resources-for-the-general-surgery-clerkship
#15
Janice A Taylor, Christiana M Shaw, Sanda A Tan, John L Falcone
BACKGROUND: To define resources deemed most important to medical students on their general surgery clerkship, we evaluated their material utilization. METHODS: A prospective study was conducted amongst third-year medical students using a 20-item survey. Descriptive statistics were performed on the demographics. Kruskal-Wallis and Mann-Whitney analyses were performed on the Likert responses (α = 0.05). RESULTS: Survey response was 69.2%...
January 30, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28236640/measuring-material-wealth-in-low-income-settings-a-conceptual-and-how-to-guide
#16
Bonnie N Kaiser, Daniel Hruschka, Craig Hadley
Although wealth is consistently found to be an important predictor of health and well-being, there remains debate as to the best way to conceptualize and operationalize wealth. In this article, we focus on the measurement of economic resources, which is one among many forms of wealth. We provide an overview of the process of measuring material wealth, including theoretical and conceptual considerations, a how-to guide based on the most common approach to measurement, and a review of important theoretical and empirical questions that remain to be resolved...
February 25, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28236334/pi-radsv2-how-we-do-it
#17
Matthew D Greer, Peter L Choyke, Baris Turkbey
: Much criticism has been leveled at screening for prostate cancer using prostate-specific antigen (PSA) testing, yet there is no suitable replacement to improve the detection of clinically significant cancer (CSC). Prostate multiparametric magnetic resonance imaging (mpMRI) combined with mpMRI-guided biopsies is one possible solution, as it reduces detection of low-grade disease and increases detection of CSC. However, mpMRI is critically limited by lack of standardization across institutions and low interobserver agreement...
February 25, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28236171/reward-based-contextual-learning-supported-by-anterior-cingulate-cortex
#18
Akina Umemoto, Azadeh HajiHosseini, Michael E Yates, Clay B Holroyd
The anterior cingulate cortex (ACC) is commonly associated with cognitive control and decision making, but its specific function is highly debated. To explore a recent theory that the ACC learns the reward values of task contexts (Holroyd & McClure in Psychological Review, 122, 54-83, 2015; Holroyd & Yeung in Trends in Cognitive Sciences, 16, 122-128, 2012), we recorded the event-related brain potentials (ERPs) from participants as they played a novel gambling task. The participants were first required to select from among three games in one "virtual casino," and subsequently they were required to select from among three different games in a different virtual casino; unbeknownst to them, the payoffs for the games were higher in one casino than in the other...
February 24, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28236104/uterine-fibroid-therapy-using-interventional-radiology-mini-invasive-treatments-current-perspective
#19
Carlo Masciocchi, Francesco Arrigoni, Fabiana Ferrari, Aldo Victor Giordano, Sonia Iafrate, Ilaria Capretti, Ester Cannizzaro, Alfonso Reginelli, Anna Maria Ierardi, Chiara Floridi, Alessio Salvatore Angileri, Luca Brunese, Antonio Barile
Uterine fibroids are common benign tumors of unclear etiopathology that affect the female reproductive tract. They are responsible for considerable morbidity and deterioration of life quality, and may have a negative impact on the reproductive system as well. Besides surgery aided by uterus-saving techniques, several minimally invasive procedures are now available within the field of interventional radiology that represent a valid solution for women who desire pregnancy and relief from disease-specific symptomatology...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28236035/osteoporosis-treat-to-target
#20
REVIEW
E Michael Lewiecki
PURPOSE OF REVIEW: Treat-to-target (goal-directed therapy) has been proposed as a strategy to assist clinicians in selecting the most appropriate initial treatment for osteoporosis and guiding subsequent decisions to continue, change, or stop treatment. This is a review of the current medical evidence regarding treatment targets and potential clinical applications in managing patients with osteoporosis. RECENT FINDINGS: Analyses of randomized placebo-controlled trials of approved agents to treat osteoporosis have generally shown that larger increases in bone mineral density are associated with greater reduction in fracture risk...
February 24, 2017: Current Osteoporosis Reports
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