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in vivo hemolysis

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https://www.readbyqxmd.com/read/28504558/nanoformulated-water-soluble-paclitaxel-to-enhance-drug-efficacy-and-reduce-hemolysis-side-effect
#1
Weiting Gu, Jie Chen, Prabir Patra, Xiaoyan Yang, Quanrong Gu, Lingxuan Wei, Jason P Acker, Beihua Kong
Surgery, chemotherapy, and radiotherapy are the three top cancer treatment modalities. Paclitaxel (PTX) is one of the most widely used chemotherapy drugs. However, its clinical applications have been significantly limited due to: (i) serious hemolysis effect of currently available commercial paclitaxel formulations and (ii) its water insolubility. An easy way to deliver paclitaxel by a new nanocarrier system using pluronic copolymers of P123/F68 and Sorbitan monopalmitate (Span 40) was reported in our previous research article...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28503385/intervention-effects-of-five-cations-and-their-correction-on-hemolytic-activity-of-tentacle-extract-from-the-jellyfish-cyanea-capillata
#2
Hui Zhang, Qianqian Wang, Liang Xiao, Liming Zhang
Cations have generally been reported to prevent jellyfish venom-induced hemolysis through multiple mechanisms by spectrophotometry. Little attention has been paid to the potential interaction between cations and hemoglobin, potentially influencing the antagonistic effect of cations. Here, we explored the effects of five reported cations, La(3+), Mn(2+), Zn(2+), Cu(2+) and Fe(2+), on a hemolytic test system and the absorbance of hemoglobin, which was further used to measure their effects on the hemolysis of tentacle extract (TE) from the jellyfish Cyanea capillata...
2017: PeerJ
https://www.readbyqxmd.com/read/28500731/alternative-plasticizer-4-cyclohexene-1-2-dicarboxylic-acid-dinonyl-ester-for-blood-containers-with-protective-effects-on-red-blood-cells-and-improved-cold-resistance
#3
Yuki Morishita, Yusuke Nomura, Chie Fukui, Ayano Fujisawa, Kayo Watanabe, Hideo Fujimaki, Hidefumi Kumada, Kaoru Inoue, Tomomi Morikawa, Miwa Takahashi, Tsuyoshi Kawakami, Hideyuki Sakoda, Tomokazu Mukai, Toshiyasu Yuba, Ken-Ichi Inamura, Akito Tanoue, Ken-Ichi Miyazaki, Ung-Il Chung, Kumiko Ogawa, Midori Yoshida, Yuji Haishima
Di (2-ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC), is eluted from PVC-made blood containers and protects against red blood cell (RBC) hemolysis. However, concerns have arisen regarding the reproductive and developmental risks of DEHP in humans, and the use of alternative plasticizers for medical devices has been recommended worldwide. In this study, we propose that the use of a novel plasticizer, 4-cyclohexene-1,2-dicarboxylic acid dinonyl ester (DL9TH), could help produce more useful and safe blood containers...
May 13, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28485579/marriage-of-albumin-gadolinium-complexes-and-mos2-nanoflakes-as-cancer-theranostics-for-dual-modality-magnetic-resonance-photoacoustic-imaging-and-photothermal-therapy
#4
Liang Chen, Xiaojun Zhou, Wei Nie, Wei Feng, Qianqian Zhang, Weizhong Wang, Yanzhong Zhang, Zhigang Chen, Peng Huang, Chuanglong He
The construction of safe and stable theranostics is beneficial to realize simultaneous cancer diagnosis and treatment. In this study, bovine serum albumin-gadolinium (BSA-Gd) complexes and MoS2 nanoflakes (MoS2-Gd-BSA) were successfully married as cancer theranostics for dual-modality magnetic resonance (MR)/photoacoustic (PA) imaging and photothermal therapy (PTT). BSA-Gd complexes were prepared by the biomineralization method and then conjugated with MoS2 nanoflakes via an amide bond. The as-prepared MoS2-Gd-BSA possessed a good photostability and photothermal effect...
May 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28482571/optimization-and-development-of-maghemite-%C3%AE-fe2o3-filled-poly-l-lactic-acid-plla-thermoplastic-polyurethane-tpu-electrospun-nanofibers-using-taguchi-orthogonal-array-for-tissue-engineering-heart-valve
#5
Ehsan Fallahiarezoudar, Mohaddeseh Ahmadipourroudposht, Ani Idris, Noordin Mohd Yusof
Tissue engineering (TE) is an advanced principle to develop a neotissue that can resemble the original tissue characteristics with the capacity to grow, to repair and to remodel in vivo. This research proposed the optimization and development of nanofiber based scaffold using the new mixture of maghemite (γ-Fe2O3) filled poly-l-lactic acid (PLLA)/thermoplastic polyurethane (TPU) for tissue engineering heart valve (TEHV). The chemical, structural, biological and mechanical properties of nanofiber based scaffold were characterized in terms of morphology, porosity, biocompatibility and mechanical behaviour...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28481506/functional-silver-nanocomposites-as-broad-spectrum-antimicrobial-and-biofilm-disrupting-agents
#6
Qianqian Guo, Yu Zhao, Xiaomei Dai, Tianqi Zhang, Yunjian Yu, Xinge Zhang, Chaoxing Li
Biofilms' tolerance has become a serious clinical concern due to their formidable resistance to conventional antibiotics and prevalent virulence. Therefore, there is an urgent need to develop alternative antimicrobial agents to eradicate biofilms but avoid using antibiotics. Herein, we successfully developed polymer functional silver nanocomposites by reduction of silver nitrate in the presence of a biocompatible carbohydrate polymer and a membrane-disrupting cationic polymer. The nanocomposites presented effective antimicrobial activity against Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus and Bacillus amyloliquefaciens)...
May 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28475918/inhibition-of-the-infectivity-and-inflammatory-response-of-influenza-virus-by-arbidol-hydrochloride-in-vitro-and-in-vivo-mice-and-ferret
#7
Yutao Wang, Yuewen Ding, Chunguang Yang, Runfeng Li, Qiuling Du, Yanbing Hao, Zhengtu Li, Haiming Jiang, Jin Zhao, Qiaoyan Chen, Zifeng Yang, Zhanlong He
Influenza virus infections are the main contagious respiratory disease with high levels of morbidity and mortality worldwide. Antiviral drugs are indispensable for the prophylaxis and treatment of influenza and other respiratory viral infections. In this study, the Arbidol hydrochloride (ARB), which has been licensed in Russia and China, is used to investigate its anti-viral and anti-inflammatory efficacy in vitro and in vivo. The antiviral results in vitro showed that ARB had a better inhibition on Influenza virus A/PR/8/34 (H1N1), A/Guangdong/GIRD07/09 (H1N1), A/Aichi/2/68 (H3N2), A/HK/Y280/97 (H9N2) with IC50 ranging from 4...
May 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28471183/one-pot-synthesis-of-mos2-nanoflakes-with-desirable-degradability-for-photothermal-cancer-therapy
#8
Liang Chen, Yihan Feng, Xiaojun Zhou, Qianqian Zhang, Wei Nie, Weizhong Wang, Yanzhong Zhang, Chuanglong He
Developing biodegradable photothermal agent holds great significance for potential clinical translation of photothermal therapy. In the current study, one-pot hydrothermal synthesis of MoS2 nanoflakes with desirable degradation capability was presented. The participation of poly(acrylic acid) (PAA) in hydrothermal process could not only facilitate the modification of polyethylene glycol (PEG), but also bestow degradability to the prepared MoS2 nanoflakes. Moreover, the PEGylated hybrid nanoflakes (MoS2-PPEG) also exhibited excellent stability in various medium and outstanding photothermal properties...
May 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28458720/role-of-red-blood-cells-in-haemostasis-and-thrombosis
#9
Rustem I Litvinov, John W Weisel
In contrast to an obsolete notion that erythrocytes, or red blood cells (RBCs), play a passive and minor role in hemostasis and thrombosis, over the past decades there has been increasing evidence that RBCs have biologically and clinically important functions in blood clotting and its disorders. This review summarizes the main mechanisms that underlie the involvement of RBCs in hemostasis and thrombosis in vivo, such as rheological effects on blood viscosity and platelet margination, aggregation and deformability of RBCs; direct adhesion and indirect biochemical interactions with endothelial cells and platelets, etc...
February 2017: ISBT Science Series
https://www.readbyqxmd.com/read/28457630/non-invasive-thrombolysis-using-microtripsy-in-a-porcine-deep-vein-thrombosis-model
#10
Xi Zhang, Jonathan J Macoskey, Kimberly Ives, Gabe E Owens, Hitinder S Gurm, Jiaqi Shi, Matthew Pizzuto, Charles A Cain, Zhen Xu
Histotripsy is a non-invasive therapeutic technique that uses ultrasound generated from outside the body to create controlled cavitation in targeted tissue, and fractionates it into acellular debris. We have developed a new histotripsy approach, termed microtripsy, to improve targeting accuracy and to avoid collateral tissue damage. This in vivo study evaluates the safety and efficacy of microtripsy for non-invasive thrombolysis in a porcine deep vein thrombosis model. Acute thrombi were formed in left femoral veins of pigs (∼35 kg) by occluding the vessel using two balloon catheters and infusing with thrombin...
July 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28456565/red-blood-cell-membrane-water-permeability-increases-with-length-of-ex%C3%A2-vivo-storage
#11
Abdulrahman Alshalani, Jason P Acker
Water transport across the red blood cell (RBC) membrane is an essential cell function that needs to be preserved during ex vivo storage. Progressive biochemical depletion during storage can result in significant conformational and compositional changes to the membrane. Characterizing the changes to RBC water permeability can help in evaluating the quality of stored blood products and aid in the development of improved methods for the cryopreservation of red blood cells. This study aimed to characterize the water permeability (Lp), osmotically inactive fraction (b), and Arrhenius activation energy (Ea) at defined storage time-points throughout storage and to correlate the observed results with other in vitro RBC quality parameters...
April 26, 2017: Cryobiology
https://www.readbyqxmd.com/read/28416183/inhibition-of-the-in-vitro-growth-of-babesia-bigemina-babesia-caballi-and-theileria-equi-parasites-by-trifluralin-analogues
#12
Marta G Silva, Donald P Knowles, Sandra Antunes, Ana Domingos, Maria A Esteves, Carlos E Suarez
Bovine and equine babesiosis caused by Babesia bovis, Babesia bigemina and Babesia caballi, along with equine theileriosis caused by Theileria equi are global tick-borne hemoprotozoan diseases characterized by fever, anemia, weight losses and abortions. A common feature of these diseases are transition from acute to chronic phases, in which parasites may persist in the hosts for life. Antiprotozoal drugs are important for managing infection and disease. Previous research demonstrated that trifluralin analogues, designated (TFLAs) 1-15, which specifically bind to regions of alpha-tubulin protein in plants and protozoan parasites, have the ability to inhibit the in vitro growth of B...
April 10, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28415521/effect-of-halloysite-nanotubes-on-the-structure-and-function-of-important-multiple-blood-components
#13
Keke Wu, Ru Feng, Yanpeng Jiao, Changren Zhou
Many researchers have investigated the application of halloysite nanotubes (HNTs) in biomedicine, because of their special nanoscale hollow tubular structure. Although the cytocompatibility of HNTs has been studied, their blood compatibility has not been systematically investigated. In this work, the effect of HNTs on the structure and function of different blood components has been studied, including the morphology and hemolysis of red blood cells (RBCs). Based on scanning electron microscopy (SEM) observations, optical density test and flow cytometry analysis, we found that HNTs can affect the morphology and membrane integrity of RBCs in phosphate buffered saline (PBS) in a content-dependent way...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415385/antitubercular-activity-of-zno-nanoparticles-prepared-by-solution-combustion-synthesis-using-lemon-juice-as-bio-fuel
#14
Prashanth Gopala Krishna, Prashanth Paduvarahalli Ananthaswamy, Priyanka Trivedi, Vinita Chaturvedi, Nagabhushana Bhangi Mutta, Ananda Sannaiah, Amani Erra, Tejabhiram Yadavalli
In this study, we report the synthesis, structural and morphological characteristics of zinc oxide (ZnO) nanoparticles using solution combustion synthesis method where lemon juice was used as the fuel. In vitro anti-tubercular activity of the synthesized ZnO nanoparticles and their biocompatibility studies, both in vitro and in vivo were carried out. The synthesized nanoparticles showed inhibition of Mycobacterium tuberculosis H37Ra strain at concentrations as low as 12.5μg/mL. In vitro cytotoxicity study performed with normal mammalian cells (L929, 3T3-L1) showed that ZnO nanoparticles are non-toxic with a Selectivity Index (SI) >10...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28400318/hemopexin-counteracts-systolic-dysfunction-induced-by-heme-driven-oxidative-stress
#15
Giada Ingoglia, Can Martin Sag, Nikolai Rex, Lucia De Franceschi, Francesca Vinchi, James Cimino, Sara Petrillo, Stefan Wagner, Klaus Kreitmeier, Lorenzo Silengo, Fiorella Altruda, Lars S Maier, Emilio Hirsch, Alessandra Ghigo, Emanuela Tolosano
Heart failure is a leading cause of morbidity and mortality in patients affected by different disorders associated to intravascular hemolysis. The leading factor is the presence of pathologic amount of pro-oxidant free heme in the bloodstream, due to the exhaustion of the natural heme scavenger Hemopexin (Hx). Here, we evaluated whether free heme directly affects cardiac function, and tested the therapeutic potential of replenishing serum Hx for increasing serum heme buffering capacity. The effect of heme on cardiac function was assessed in vitro, on primary cardiomyocytes and H9c2 myoblast cell line, and in vivo, in Hx(-/-) mice and in genetic and acquired mouse models of intravascular hemolysis...
April 8, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28396544/synthetic-p-ppgpp-analogue-inhibitor-of-stringent-response-in-mycobacteria
#16
Kirtimaan Syal, Kelly Flentie, Neerupma Bhardwaj, Krishnagopal Maiti, Narayanaswamy Jayaraman, Christina L Stallings, Dipankar Chatterji
Bacteria elicit an adaptive response against hostile conditions such as starvation and other kind of stresses. Their ability to survive such conditions depends on, in part, stringent response pathways. (p)ppGpp, considered to be the master regulator of stringent response, is a novel target for inhibiting the survival of the bacteria. In mycobacteria, the (p)ppGpp synthetase activity of bifunctional Rel is critical for its stress response and persistence inside the host. Our aim was to design an inhibitor of (p)ppGpp synthesis, follow efficiency through enzyme kinetics, and assess its phenotypic effects in mycobacteria...
April 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28382868/prooxidant-antioxidant-balance-and-antioxidant-properties-of-thuja-orientalis-l-a-potential-therapeutic-approach-for-diabetes-mellitus
#17
Daryoush Hamidi Alamdari, Malihe Aghasizadeh-Sharbaf, Maryam Mohadjerani, Gordon A Ferns, Amir Avan
BACKGROUND: Diabetes mellitus (DM) is a major health problem with an increasing global prevalence. It is usually associated with an imbalance between pro-oxidant mechanisms and antioxidant defenses, contributing to oxidative-stress, and this leads to an increased susceptibility to endothelial dysfunction, atherosclerosis, insulin-resistance and impaired-pancreatic β-cell function. OBJECTIVE: We have assessed the Prooxidant-antioxidant balance (PAB) and anti-haemolytic effect of Thuja orientalis L using the PAB assay and the analysis of hematological markers...
April 4, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/28380410/quercetin-exhibits-adjuvant-activity-by-enhancing-th2-immune-response-in-ovalbumin-immunized-mice
#18
Divya Singh, Himanshi Tanwar, Bindhya Jayashankar, Jyoti Sharma, Swetha Murthy, Sudipta Chanda, Shashi Bala Singh, Lilly Ganju
Quercetin, one of the most abundant of plant flavonoids, has been studied with a great deal of attention over the last several decades mainly for its properties in inflammation and allergy. In this study, we are reporting for the first time the in vivo immunostimulatory activity of quercetin in ovalbumin immunized Balb/c mice. Administration of quercetin (50mg/kg body weight) along with ovalbumin antigen showed increased ovalbumin specific serum IgG antibody titres in comparison to the control group (p<0...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28377528/listeriolysin-s-is-a-streptolysin-s-like-virulence-factor-that-targets-exclusively-prokaryotic-cells-in-vivo
#19
Juan J Quereda, Marie A Nahori, Jazmín Meza-Torres, Martin Sachse, Patricia Titos-Jiménez, Jaime Gomez-Laguna, Olivier Dussurget, Pascale Cossart, Javier Pizarro-Cerdá
Streptolysin S (SLS)-like virulence factors from clinically relevant Gram-positive pathogens have been proposed to behave as potent cytotoxins, playing key roles in tissue infection. Listeriolysin S (LLS) is an SLS-like hemolysin/bacteriocin present among Listeria monocytogenes strains responsible for human listeriosis outbreaks. As LLS cytotoxic activity has been associated with virulence, we investigated the LLS-specific contribution to host tissue infection. Surprisingly, we first show that LLS causes only weak red blood cell (RBC) hemolysis in vitro and neither confers resistance to phagocytic killing nor favors survival of L...
April 4, 2017: MBio
https://www.readbyqxmd.com/read/28369971/red-blood-cells-derived-from-whole-blood-treated-with-riboflavin-and-ultraviolet-light-maintain-adequate-survival-in-vivo-after-21-days-of-storage
#20
RANDOMIZED CONTROLLED TRIAL
Jose A Cancelas, Sherrill J Slichter, Neeta Rugg, P Gayle Pratt, Shawnagay Nestheide, Jill Corson, Esther Pellham, Marty Huntington, Raymond P Goodrich
BACKGROUND: Pathogen reduction (PR) of whole blood (WB) may increase blood safety when applied before component separation. This study evaluates the in vivo performance of red blood cells (RBCs) derived from WB treated with the riboflavin and ultraviolet (UV) light PR (Mirasol) system. STUDY DESIGN AND METHODS: This was a prospective, two-center, single-blind, randomized, two-period, crossover clinical trial designed to evaluate autologous (51) Cr/(99m) Tc-radiolabeled recovery and survival of RBCs derived from Mirasol-treated WB compared to untreated WB...
May 2017: Transfusion
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