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in vivo hemolysis

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https://www.readbyqxmd.com/read/29454237/liposomes-of-dimeric-artesunate-phospholipid-a-combination-of-dimerization-and-self-assembly-to-combat-malaria
#1
Muhammad Ismail, Longbing Ling, Yawei Du, Chen Yao, Xinsong Li
Artemisinin and its derivatives are highly effective drugs in the treatment of P. falciparum malaria. However, their clinical applications face challenges because of short half-life, poor bioavailability and growing drug resistance. In this article, novel dimeric artesunate phospholipid (Di-ART-GPC) based liposomes were developed by combination of dimerization and self-assembly to address these shortcomings. Firstly, Di-ART-GPC conjugate was synthesized by a facile esterification of artesunate (ART) and glycerophosphorylcholine (GPC) and confirmed by MS, 1 H NMR and 13 C NMR...
February 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29454058/carboxymethyl-konjac-glucomannan-crosslinked-chitosan-sponges-for-wound-dressing
#2
Yu Xie, Zeng-Xing Yi, Jian-Xun Wang, Tong-Gang Hou, Qiong Jiang
In this paper, carboxymethyl konjac glucomannan (CMKGM) was obtained by carboxyl modification of konjac glucomannan. Then CMKGM and chitosan (CS) were crosslinked and freeze-dried to prepare CMKGM/CS composite sponges with different proportions. The structure and micromorphology of CMKGM/CS sponges were investigated by FTIR spectroscopy and SEM. The SEM results showed that the pore structure of the composite sponge gradually increased with the increase of CMKGM content. To assess the applicability of CMKGM/CS composite sponges as wound dressing, the swelling behavior, water vapor transmission rate (WVTR), biocompatibility (cytotoxicity and hemolysis) were analyzed...
February 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29435994/evaluation-of-the-novel-centrifugal-pump-capiox-sl-in-chronic-large-animal-experiments
#3
Kei Iizuka, Nobumasa Katagiri, Yoshiaki Takewa, Tomonori Tsukiya, Toshihide Mizuno, Yosuke Itamochi, Kouko Kumano, Eisuke Tatsumi
In the development of a new device for extracorporeal circulation, long-term durability and biocompatibility are required. The CAPIOX SL Pump (SL pump, Terumo Corporation, Tokyo, Japan), which is a centrifugal pump using a two-pivot bearing, was developed with the hope of suppressing pump thrombus formation around the bearings. This study aimed to evaluate the in vivo performance of the SL pump in the condition assumed severe clinical situation for long-term extracorporeal membrane oxygenation (ECMO) support...
February 12, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29425646/immunomodulatory-hemolytic-and-cytotoxic-activity-potentials-of-triterpenoid-saponins-from-eight-cephalaria-species
#4
Nazli Boke Sarikahya, Ayse Nalbantsoy, Hilal Top, Ramazan Suleyman Gokturk, Huseyin Sumbul, Suheyla Kirmizigul
BACKGROUND: Saponins isolated from a number of plants possess a broad spectrum of biological and pharmacological activities by using in vitro and in vivo bioassays. The recent investigations and findings in biological activity studies of saponins have mostly focused on immunomodulatory, hemolytic and cytotoxic properties. HYPOTHESIS/PURPOSE: Considering the great potential of saponins as bioactive agents, we investigated the cytotoxic, hemolytic and immunomodulatory activities of nineteen triterpenoid saponins from the aerial parts of eight Cephalaria species from Turkey...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29424474/a-critical-review-of-the-application-of-polymer-of-low-concern-and-regulatory-criteria-to-fluoropolymers
#5
REVIEW
Barbara J Henry, Joseph P Carlin, Jon A Hammerschmidt, Robert C Buck, L William Buxton, Heidelore Fiedler, Jennifer Seed, Oscar Hernandez
Per- and poly-fluoroalkyl substances (PFAS) are a group of fluorinated substances that are in the focus of researchers and regulators due to widespread presence in the environment and biota, including humans, of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). Fluoropolymers, high molecular weight polymers within the PFAS group, have unique properties that constitute a distinct class within the PFAS group. Fluoropolymers have thermal, chemical, photochemical, hydrolytic, oxidative and biological stability...
February 9, 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29396875/interference-of-in-vitro-hemolysis-complete-blood-count
#6
Gabriela de Jonge, Talita L Dos Santos, Bruno R Cruz, Mackelly Simionatto, Jeanine I M Bittencourt, Everson A Krum, Mariane F Moss, Danielle Cristyane K Borato
BACKGROUND: Hemolysis may occur in vivo, under pathological conditions, or in vitro, related to pre-analytical errors. Hemolyzed samples may produce unreliable results, leading to errors in diagnostic and monitoring evaluations. This study aims to evaluate the interference of in vitro hemolysis on the interpretation of the parameters of the blood cell-counting performed by the impedance method. METHODS: Peripheral blood samples were collected in anticoagulant K2-EDTA and subsequently divided into three 1...
February 3, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29377292/glucose-6-phosphate-dehydrogenase-deficient-red-blood-cell-units-are-associated-with-decreased-post-transfusion-red-blood-cell-survival-in-children-with-sickle-cell-disease
#7
Eyal Sagiv, Ross M Fasano, Naomi L C Luban, Cassandra D Josephson, Sean R Stowell, John D Roback, Richard O Francis, Marianne E M Yee
Chronic transfusion therapy (CTT) for sickle cell disease (SCD) reduces disease morbidity by suppressing the amount of circulating hemoglobin S (HbS)-containing red blood cells (RBC). The effectiveness of CTT depends on the rate of RBC clearance. Glucose-6-phosphate dehydrogenase (G6PD) deficient donor RBC may exhibit increased hemolysis, but it is unknown if transfusion of these units results in less effective transfusion outcomes in SCD. Children with SCD on CTT were followed prospectively for multiple transfusions...
January 27, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29351418/red-blood-cell-antibody-induced-anemia-causes-differential-degrees-of-tissue-hypoxia-in-kidney-and-brain
#8
Nikhil Mistry, C David Mazer, John G Sled, Alan H Lazarus, Lindsay S Cahill, Max Solish, Yu-Qing Zhou, Nadya Romanova, Alexander Gm Hare, Allan Doctor, Joseph A Fisher, Keith R Brunt, Jeremy A Simpson, Gregory M T Hare
Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. A red blood cell (RBC)-specific antibody model was utilized to determine if moderate subacute anemia could result in tissue hypoxia as a potential mechanism of injury. Cardiovascular and hypoxic cellular responses were measured in transgenic mice capable of expressing hypoxia-inducible factor-1α (HIF-1α)-luciferase activity in vivo. Antibody-mediated anemia was associated with mild intravascular hemolysis (6 hours) and splenic RBC sequestration (day 4), resulting in a nadir hemoglobin concentration of 89{plus minus}13 g/L at day 4...
January 10, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29344229/preparation-and-characterization-of-the-adriamycin-loaded-amphiphilic-chitosan-nanoparticles-and-their-application-in-the-treatment-of-liver-cancer
#9
Chang-Hua Kou, Jin Han, Xi-Lin Han, Hui-Jie Zhuang, Zi-Ming Zhao
In the present study, two nanoparticles including lactose myristoyl carboxymethyl chitosan (LMCC) and algal polysaccharide myristoyl carboxymethyl chitosan (AMCC), were obtained for hepatic-targeted Adriamycin (ADM) drug delivery systems. ADM was successfully loaded into the LMCC or AMCC nanoparticle by dialysis. The release function and liver targeting of the nanoparticles was explored, and it was revealed that ADM release from the nanoparticles was greatest at acidic pH 5.5. ADM-conjugated nanoparticles were readily taken up by HU7 human hepatocellular carcinoma cells, relative to HT22 mouse hippocampal neuron cells in vitro...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29326487/antitoxin-activity-of-aqueous-extract-of-cyclea-peltata-root-against-naja-naja-venom
#10
Thulasi Sivaraman, N S Sreedevi, S Meenatchisundaram, R Vadivelan
OBJECTIVES: Snakebites are a significant and severe global health problem. Till date, anti-snake venom serum is the only beneficial remedy existing on treating the snakebite victims. As antivenom was reported to induce early or late adverse reactions to human beings, snake venom neutralizing potential for Cyclea peltata root extract was tested for the present research by ex vivo and in vivo approaches on Naja naja toxin. MATERIALS AND METHODS: Ex vivo evaluation of venom toxicity and neutralization assays was carried out...
July 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29320951/glutathione-conjugated-polyethylenimine-on-the-surface-of-fe3o4-magnetic-nanoparticles-as-a-theranostic-agent-for-targeted-and-controlled-curcumin-delivery
#11
Navid Aeineh, Fahimeh Salehi, Mohammad Akrami, Firouzeh Nemati, Masoumeh Alipour, Milad Ghorbani, Banafsheh Nikfar, Fatemeh Salehian, Nader Riyahi Alam, Seyed Esmaeil Sadat Ebrahimi, Alireza Foroumadi, Mehdi Khoobi, Mohammadreza Rouini, Maryam Dibaei, Ismaeil Haririan, Mohammad Reza Ganjali, Saeed Safaei
Theranostics with the ability to simultaneous monitoring of treatment progress and controlled delivery of therapeutic agents has become as an emerging therapeutic paradigm in cancer therapy. In this study, we have developed a novel surface functionalized iron oxide nanoparticle using polyethyleneimine (PEI) and glutathione (GSH) for targeted curcumin (CUR) delivery and acceptable pH sensitive character. The developed magnetic nanoparticles (MNPs) were physicochemically characterized by FT-IR, XRD, FE-SEM and TEM...
January 11, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29313260/preparation-and-evaluation-of-progesterone-nanocrystals-to-decrease-muscle-irritation-and-improve-bioavailability
#12
Li Li, Wanqing Li, Jianxu Sun, Hui Zhang, Jing Gao, Fei Guo, Xi Yang, Xun Zhang, Ying Li, Aiping Zheng
Progesterone (PG) is a crucial immunomodulatory agent during early pregnancy, and nowadays PG oil-based injection (PG/OI) has a huge market all over the world. However, PG/OI may accumulate the local muscle and further cause irritations after long-term administration. In this study, PG nanocrystals (PG/NCs) injection was developed to decrease muscle toxicity. PG/NCs injection containing 10% (w/v) PG was first prepared using a wet grinding method. Then, particle size, zeta potential, morphology powder, X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR) studies were carried out to evaluate the characteristics of dosage form...
January 8, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29302668/near-infrared-optical-and-x-ray-computed-tomography-dual-modal-imaging-probe-based-on-novel-lanthanide-doped-k0-3bi0-7f2-4-upconversion-nanoparticles
#13
Ran An, Pengpeng Lei, Peng Zhang, Xia Xu, Jing Feng, Hongjie Zhang
A novel K0.3Bi0.7F2.4 upconversion (UC) matrix has been prepared successfully by a solvothermal method. K0.3Bi0.7F2.4:Yb3+/Ln3+ (Ln = Er, Ho, Tm) upconversion nanoparticles (UCNPs) show a corresponding excellent upconversion luminescence (UCL) under 980 nm laser irradiation. Especially, the strong near-infrared (NIR) UCL of K0.3Bi0.7F2.4:20% Yb3+/0.5% Tm3+ (abbreviated as BYT) UCNPs is suitable for deep tissue optical imaging. Moreover, the high X-ray absorption coefficient of Bi makes the as-prepared UCNPs favorable for computed tomography (CT) imaging...
January 5, 2018: Nanoscale
https://www.readbyqxmd.com/read/29287328/effects-of-low-sulfur-dioxide-concentrations-on-bioactive-compounds-and-antioxidant-properties-of-aglianico-red-wine
#14
Morena Gabriele, Chiara Gerardi, Jeannette J Lucejko, Vincenzo Longo, Laura Pucci, Valentina Domenici
This study analyzed the effect of low sulfur dioxide concentrations on the chromatic properties, phytochemical composition and antioxidant activity of Aglianico red wines with respect to wines produced from conventional winemaking. We determined the phytochemical composition by spectrophotometric methods and HPLC-DAD analysis and the in vitro antioxidant activity of different wine samples by the ORAC assay. The main important classes of fluorophore molecules in red wine were identified by Front-Face fluorescence spectroscopy, and the emission intensity trend was investigated at various sulfur dioxide concentrations...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29247686/folic-acid-modified-liposomal-drug-delivery-strategy-for-tumor-targeting-of-5-fluorouracil
#15
Eskandar Moghimipour, Farid Abedin Dorkoosh, Mohsen Rezaei, Zahra Ramezani, Mohsen Amini, Maryam Kouchak, Kambiz Ahmadi Angali, Somayeh Handali
The aim of this study was to develop a liposomal formulation to selectively target cancer cells. Liposomes were prepared using thin layer method and folic acid (FA) was applied for targeted delivery of 5FU to cancer cells. Liposomes prepared were characterized for encapsulation efficiency (EE%), morphology and their particle size. Cellular uptake, cytotoxicity study and ROS production were evaluated using CT26 cell line. Hemolysis test was performed on rat red blood cells (RBCs). Moreover, the efficacy of targeted liposomes were investigated by in vivo antitumor activity and tissue toxicities were studied by histological examination...
December 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29240631/in-vivo-5-day-animal-studies-of-a-compact-wearable-pumping-artificial-lung
#16
Shalv P Madhani, Brian J Frankowski, Sang-Ho Ye, Greg W Burgreen, William R Wagner, Robert Kormos, Jonathan D'Cunha, William J Federspiel
Recent studies show improved outcomes in ambulated lung failure patients. Ambulation still remains a challenge in these patients. This necessitates development of more compact and less cumbersome respiratory support specifically designed to be wearable. The Paracorporeal Ambulatory Assist Lung (PAAL) is being designed for providing ambulatory support in lung failure patients during bridge to transplant or recovery. We previously published in vitro and acute in vivo results of the PAAL. This study further evaluates the PAAL for 5 days...
December 11, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29235395/adjuvant-activity-of-ethanol-extract-of-hippophae-rhamnoides-leaves-with-inactivated-rabies-virus-antigen
#17
D Singh, B Jayashankar, K P Mishra, H Tanwar, S N Madhusudana, A Y Belludi, R Tulsawani, S B Singh, L Ganju
CONTEXT: Hippophae rhamnoides L. (Elaeagnaceae), commonly known as seabuckthorn (SBT), is known for its medicinal and nutritional properties. OBJECTIVE: Evaluation of in vivo adjuvant activity of SBT leaf extract (SBTE) with inactivated rabies virus antigen (Rb). MATERIALS AND METHODS: Swiss albino mice were immunized with aqueous-alcoholic SBTE (100 mg/kg body weight) or algel (aluminium hydroxide gel) with or without Rb (5% v/v). After priming, booster was administered on day 14...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29219172/roles-of-lipocalin-2-and-adiponectin-in-iron-overload-cardiomyopathy
#18
REVIEW
Natthaphat Siri-Angkul, Siriporn C Chattipakorn, Nipon Chattipakorn
Thalassemia is among the most common genetic diseases worldwide. Ineffective erythropoiesis, chronic hemolysis, and regular blood transfusion in thalassemia patients lead to increased iron burden. Iron overload cardiomyopathy is the most severe co-morbidity and most common cause of mortality in thalassemia patients. Although its associated mechanisms are still not completely understood, cellular iron mishandling, chronic inflammation, and oxidative stress appear to be the key processes involved. In order to acquire a more comprehensive insight of the impact of cardiac iron overload, these alterations need to be intensively investigated...
December 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29208274/hemostatic-porous-sponges-of-cross-linked-hyaluronic-acid-cationized-dextran-by-one-self-foaming-process
#19
Jia-Ying Liu, Yang Li, Yang Hu, Gang Cheng, Enyi Ye, Chuanan Shen, Fu-Jian Xu
Effective hemostatic materials are very important for treating trauma cases. Natural polysaccharides have been particularly appealing in the development of new hemostatic materials due to their unique functions in human bodies. In this work, different polysaccharide-based hemostatic porous sponges (SHDP or SHDQ) of cross-linked hyaluronic acid (HA)/cationized dextran were readily prepared by the self-foaming process of HA and poly((2-dimethyl amino)-ethyl methacrylate)-grafted dextran (Dex-PDM) or partially-quaternized Dex-PDM in the presence of sodium trimetaphosphate crosslinkers...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29205354/podocytes-are-new-cellular-targets-of-haemoglobin-mediated-renal-damage
#20
Alfonso Rubio-Navarro, Maria Dolores Sanchez-Niño, Melania Guerrero-Hue, Cristina García-Caballero, Eduardo Gutiérrez, Claudia Yuste, Ángel Sevillano, Manuel Praga, Javier Egea, Elena Román, Pablo Cannata, Rosa Ortega, Isabel Cortegano, Belén de Andrés, María Luisa Gaspar, Susana Cadenas, Alberto Ortiz, Jesús Egido, Juan Antonio Moreno
Recurrent and massive intravascular haemolysis induces proteinuria, glomerulosclerosis, and progressive impairment of renal function, suggesting podocyte injury. However, the effects of haemoglobin (Hb) on podocytes remain unexplored. Our results show that cultured human podocytes or podocytes isolated from murine glomeruli bound and endocytosed Hb through the megalin-cubilin receptor system, thus resulting in increased intracellular Hb catabolism, oxidative stress, activation of the intrinsic apoptosis pathway, and altered podocyte morphology, with decreased expression of the slit diaphragm proteins nephrin and synaptopodin...
December 4, 2017: Journal of Pathology
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