keyword
https://read.qxmd.com/read/38369065/an-update-review-on-monoterpene-indole-alkaloids-and-biological-activities-of-tabernaemontana-species-occurring-in-brazil
#21
JOURNAL ARTICLE
Thalya Soares Ribeiro Nogueira, Milena Gonçalves Curcino Vieira, Renata Rodrigues da Silva Robaina, Raimundo Braz-Filho, Douglas da Costa Gontijo, Alaíde Braga de Oliveira, Ivo José Curcino Vieira
ETHNOPHARMACOLOGICAL RELEVANCE: The Tabernaemontana genus belongs to the Apocynaceae family of which 30 species are found in Brazil. Some Tabernaemontana species are used by Brazilian indigenous people and other communities, or are listed in the Yanomami Pharmacopeia. Ethnopharmacological data include use(s) for muscle problems, depressed sternum, back pain, abscess, indigestion, eye irritation, earache, itching, vaginal discharge, as an aid for older people who are slow and forgetful, mosquito and snake bites, infection by the human botfly larvae, calmative, and fever...
February 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38366710/optimization-of-the-zhou-tian-formula-extraction-technology-based-on-ahp-critic-method-and-analysis-of-transfer-efficiency-of-key-components-based-on-hplc-fingerprinting
#22
JOURNAL ARTICLE
Yi-Feng Ma, Yang Feng, Li-Li Yao, Pei-Shi Feng, Wei-Kang Zhou, Le-Xuan Fang, Yi Tao, Ping Wang
INTRODUCTION: Zhou Tian Formula (ZTF) is an antidepressant traditional Chinese medicine utilized widely in clinical settings for the treatment of patients with depression. However, shortcomings persist in its extraction technology and quality control. OBJECTIVE: This study aimed to propose a methodology for ZTF extraction technology based on the analytic hierarchy process (AHP)-criteria importance through intercriteria correlation (CRITIC) method and to establish a quality control framework for the efficient transfer of index components...
February 17, 2024: Phytochemical Analysis: PCA
https://read.qxmd.com/read/38358766/phillygenin-prevents-osteoclast-differentiation-and-bone-loss-by-targeting-rhoa
#23
JOURNAL ARTICLE
Jiahui Zhang, Tao Jiang, Yuxin Zhang, Kai Yang, Yichen Zhao, Qi Zhou, Zhuo Yang, Renhao Yang, Ruonan Ning, Tao Liu, Lianfu Deng, Xiaobing Xi, Xing Xu, Min Jiang
Forsythia suspensa tea is a popular traditional Chinese medicine decoction for its healthy and therapeutic benefits. However, its effects in bone metabolism were not clear. In recent study, we uncovered anti-osteoclastogenesis property of Phillygenin (Phi), a compound abundant in Forsythia suspensa leaves, and aimed to investigate the effect and mechanism of Phi on bone metabolism in vivo and in vitro. Lipopolysaccharides-induced murine calvaria osteolysis and ovariectomy-induced bone loss animal models were used to identify the bone-protective effect of Phi in vivo and micro-CT, pQCT, and TRAP staining were applied...
February 15, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38338331/in-vitro-assessment-of-cortisol-release-inhibition-bioaccessibility-and-bioavailability-of-a-chemically-characterized-scutellaria-lateriflora-l-hydroethanolic-extract
#24
JOURNAL ARTICLE
Daniele Giuseppe Buccato, Hammad Ullah, Lorenza Francesca De Lellis, Roberto Piccinocchi, Alessandra Baldi, Xiang Xiao, Carla Renata Arciola, Alessandro Di Minno, Maria Daglia
Excess cortisol release is associated with numerous health concerns, including psychiatric issues (i.e., anxiety, insomnia, and depression) and nonpsychiatric issues (i.e., osteoporosis). The aim of this study was to assess the in vitro inhibition of cortisol release, bioaccessibility, and bioavailability exerted by a chemically characterized Scutellaria lateriflora L. extract (SLE). The treatment of H295R cells with SLE at increasing, noncytotoxic, concentrations (5-30 ng/mL) showed significant inhibition of cortisol release ranging from 58 to 91%...
January 25, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38328129/amelioration-of-age-related-cognitive-decline-and-anxiety-in-mice-by-centella-asiatica-extract-varies-by-sex-dose-and-mode-of-administration
#25
Nora E Gray, Wyatt Hack, Mikah S Brandes, Jonathan A Zweig, Liping Yang, Luke Marney, Jaewoo Choi, Armando Alcazar Magana, Natasha Cerruti, Janis McFerrin, Seiji Koike, Thuan Nguyen, Jacob Raber, Joseph F Quinn, Claudia S Maier, Amala Soumyanath
We have previously reported that a water extract (CAW) of the Ayurvedic plant Centella asiatica administered in drinking water can improve cognitive deficits in mouse models of aging and neurodegenerative diseases. Here we compared the effects of CAW administered in drinking water or the diet on cognition, measures of anxiety and depression-like behavior in healthy aged mice. Three- and eighteen-month-old male and female C57BL6 mice were administered rodent AIN-93M diet containing CAW (0, 0.2, 0.5 or 1% w/w) to provide 0, 200 mg/kg/d, 500 mg/kg/d or 1000 mg/kg/d for a total of 5 weeks...
January 24, 2024: bioRxiv
https://read.qxmd.com/read/38306547/progress-of-plant-polyphenol-extracts-in-treating-depression-by-anti-neuroinflammatory-mechanism-a-review
#26
JOURNAL ARTICLE
Yuting Guo, Yan Yang
There is a growing body of evidence supporting the involvement of central nervous system inflammation in the pathophysiology of depression. Polyphenols are a diverse group of compounds known for their antioxidative and anti-inflammatory properties. They offer a promising and effective supplementary approach to alleviating neuropsychiatric symptoms associated with inflammation-induced depression. This paper provides a summary of the potential anti-neuroinflammatory mechanisms of plant polyphenol extracts against depression...
February 2, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38301302/neuropharmacological-insights-into-gardenia-jasminoides-ellis-harnessing-therapeutic-potential-for-central-nervous-system-disorders
#27
REVIEW
Ziyu Hou, Le Sun, Zheyu Jiang, Tiexin Zeng, Peiling Wu, Jiali Huang, Haibo Liu, Peigen Xiao
BACKGROUND: In China, Gardenia jasminoides Ellis (GJE) has a longstanding history of application. The Ministry of Health has listed it as one of the first pharmaceutical or food resources. In ethnic, traditional, and folk medicine, GJE has been used to treat fever and cold and relieve nervous anxiety. Recent studies have confirmed the significant efficacy of GJE for treating central nervous system (CNS) disorders, including Alzheimer's disease, Parkinson's disease, and major depressive disorder; however, GJE has not been systematically evaluated...
March 2024: Phytomedicine
https://read.qxmd.com/read/38295663/gramine-improves-sepsis-induced-myocardial-dysfunction-by-binding-to-nf-%C3%AE%C2%BAb-p105-and-inhibiting-its-ubiquitination
#28
JOURNAL ARTICLE
Ling Dao, Hengdao Liu, Ruizhen Xiu, Tianbao Yao, Renyang Tong, Longwei Xu
BACKGROUND: Sepsis and its associated heart failure are among the leading causes of death. Gramine, a natural indole alkaloid, can be extracted from a wide variety of raw plants, and it exhibits therapeutic potential in pathological cardiac hypertrophy. However, the effect of gramine on inflammatory cardiomyopathy, particularly sepsis-induced myocardial injury, remains an unexplored area. PURPOSE: To determine the role of gramine in sepsis-induced myocardial dysfunction and explore its underlying mechanism...
January 13, 2024: Phytomedicine
https://read.qxmd.com/read/38272038/vasorelaxant-effects-of-ellagitannins-isolated-from-cuphea-carthagenensis
#29
JOURNAL ARTICLE
Kaori Katiuska Yamaguchi Isla, Mirtes Midori Tanae, Maria Teresa Riggio de Lima-Landman, Pedro Melillo de Magalhães, Antônio José Lapa, Caden Souccar
Cuphea carthagenensis (Jacq.) J. F. Macbr. is a popular plant in Brazilian folk medicine owing to its hypotensive and central nervous system depressant effects. This study aimed to validate the hypotensive effect of the plant's aqueous extract (AE) in rats and examine the vascular actions of three hydrolyzable tannins, oenothein B, woodfordin C, and eucalbanin B, isolated from AE. Systolic blood pressure in unanesthetized rats was determined using the non-invasive tail-cuff method. Oral treatment of normotensive rats with 0...
January 25, 2024: Planta Medica
https://read.qxmd.com/read/38262525/potential-therapeutic-effects-of-chinese-herbal-medicine-in-postpartum-depression-mechanisms-and-future-directions
#30
REVIEW
Hongxiao Xie, Zhiqiang Xie, Fei Luan, Jiuseng Zeng, Xiumeng Zhang, Li Chen, Nan Zeng, Rong Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Postpartum depression (PPD) is a common psychiatric disorder in women after childbirth. Per data from epidemiologic studies, PPD affects about 5%-26.32% of postpartum mothers worldwide. Biological factors underlying this condition are multiple and complex and have received extensive inquiries for the roles they play in PPD. Chinese herbal medicine (CHM), which is widely used as a complementary and alternative therapy for neurological disorders, possesses multi-component, multi-target, multi-access, and low side effect therapeutic characteristics...
January 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38258776/in-vitro-and-in-silico-assessment-of-anti-inflammation-properties-of-saponarin-extracted-from-hordeum-vulgare
#31
JOURNAL ARTICLE
Revathi Boyina, Sreya Kosanam, B Sasidhar, G Raveendra Babu, D Dhachinamoorthi
BACKGROUND: Hordeum vulgare, commonly known as Barley grass, is a historically significant cultivated plant with profound implications for societies, agricultural sciences, and human nutrition. It has been valued for both sustenance and its potential medicinal properties. OBJECTIVE: This study aims to comprehensively investigate the medicinal properties of Hordeum vulgare, focusing on its potential therapeutic benefits and anti-inflammatory properties. Additionally, we seek to quantify and compare the phytochemical content of two distinct extracts: Barley Grass Hexane Extract (BGHE) and Barley grass aqueous extract (BGAQ)...
January 22, 2024: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://read.qxmd.com/read/38252090/first-report-of-powdery-mildew-caused-by-podosphaera-xanthii-on-siraitia-grosvenorii-in-guizhou-china
#32
JOURNAL ARTICLE
Yintao Pan, Lu Huang, Xing-Yu An, Shi-Ping Wu
Swingle ( Siraitia grosvenorii ), a member of the Cucurbitaceae family, stands out as a distinctive plant with both economic and medicinal significance. In October 2023, severe powdery mildew were observed on S. grosvenorii in Guiyang City (26.50°N; 106.66°E), Guizhou Province, China. About 80 % of the plants in the greenhouse showed powdery mildew symptoms. Three infected plant samples were selected for morphological and molecular analysis (GZAAS 23-0801, GZAAS 23-0802 and GZAAS 23-0803). The voucher specimens are deposited in the Key Laboratory of Agricultural Biotechnology of Guizhou Province...
January 22, 2024: Plant Disease
https://read.qxmd.com/read/38232725/therapeutic-potential-of-stilbenes-in-neuropsychiatric-and-neurological-disorders-a-comprehensive-review-of-preclinical-and-clinical-evidence
#33
REVIEW
Katarzyna Socała, Elżbieta Żmudzka, Klaudia Lustyk, Mirosław Zagaja, Virginia Brighenti, Anna Maria Costa, Marta Andres-Mach, Karolina Pytka, Ilaria Martinelli, Jessica Mandrioli, Federica Pellati, Giuseppe Biagini, Piotr Wlaź
Neuropsychiatric disorders are anticipated to be a leading health concern in the near future, emphasizing an outstanding need for the development of new effective therapeutics to treat them. Stilbenes, with resveratrol attracting the most attention, are an example of multi-target compounds with promising therapeutic potential for a broad array of neuropsychiatric and neurological conditions. This review is a comprehensive summary of the current state of research on stilbenes in several neuropsychiatric and neurological disorders such as depression, anxiety, schizophrenia, autism spectrum disorders, epilepsy, traumatic brain injury, and neurodegenerative disorders...
January 17, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38219886/experimental-and-pharmacoinformatic-approaches-unveil-the-neuropharmacological-and-analgesic-potential-of-chloroform-fraction-of-roktoshirinchi-achyranthes-ferruginea-roxb
#34
JOURNAL ARTICLE
A S M Ali Reza, Riaj Raihan, Saidul Azam, Mohammed Shahanewz, Mst Samima Nasrin, Md Abu Bakar Siddique, Md Nazim Uddin, Anik Kumar Dey, Md Golam Sadik, Ahm Khurshid Alam
ETHNOPHARMACOLOGICAL RELEVANCE: Achyranthes ferruginea (A. ferruginea) Roxb. is a common plant used in traditional medicine in Asia and Africa. It has a variety of local names, including "Gulmanci" in Nigeria, "Dangar" in Pakistan, "Thola" in Ethiopia, and "Roktoshirinchi" in Bangladesh. It is edible and has several ethnomedical uses for a wide range of illnesses, including hysteria, dropsy, constipation, piles, boils, asthma, and shigellosis. However, the neuropharmacological and analgesic potential of A...
January 12, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38217095/current-understanding-and-future-directions-of-cruciferous-vegetables-and-their-phytochemicals-to-combat-neurological-diseases
#35
REVIEW
Ramakrishna Kakarla, Praditha Karuturi, Queen Siakabinga, Matte Kasi Viswanath, Naresh Dumala, Chakravarthi Guntupalli, Buchi N Nalluri, Kojja Venkateswarlu, Vani Sai Prasanna, Gopichand Gutti, Ganesh Yadagiri, Lohitha Gujjari
Neurological disorders incidences are increasing drastically due to complex pathophysiology, and the nonavailability of disease-modifying agents. Several attempts have been made to identify new potential chemicals to combat these neurological abnormalities. At present, complete abolishment of neurological diseases is not attainable except for symptomatic relief. However, dietary recommendations to help brain development or improvement have increased over the years. In recent times, cruciferous vegetables and their phytochemicals have been identified from preclinical and clinical investigations as potential neuroprotective agents...
January 12, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38212036/-plasma-components-of-danzhi-xiaoyao-formula-and-its-mechanism-of-action-in-treating-perimenopausal-depression-based-on-uplc-q-tof-ms-e-integrated-with-network-pharmacology
#36
JOURNAL ARTICLE
Meng-Ying Li, Zi-Wei Liu, Yu-Cheng Li, Jian-Ye Quan, Ying-Lan Nie, Hai-Ming Zhang, Mei-Yu Zhang, Xiao-Mei Lian, Li Yang, Wen-Qing Hu, Jian Sun
In this study, ultra-performance liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry(UPLC-Q-TOF-MS~E) was used to analyze the plasma components of Danzhi Xiaoyao Formula after oral administration. Forty-nine plasma components were found in the serum of rats by comparing the compound extract, drug-containing serum, and blank serum. Components, such as 6-hydroxycoumarin, poricoic acid F, deoxoglabrolide, 30-norhederagenin, kanzonol R, 3',6'-di-O-galloylpaeoniflorin, 16α-hydroxytrametenolic acid, 16-deoxyporicoic acid B, 3-O-acetyl-16α-hydroxytrametenolic acid, and 16α,25-dihydroxydehydroeburiconic acid, were first found in rat serum...
December 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38212007/-mechanism-of-jiaotai-pills-in-treatment-of-depression-based-on-quantitative-proteomics
#37
JOURNAL ARTICLE
Guo-Liang Dai, Bing-Ting Sun, Ze-Yu Chen, Pei-Yao Chen, Zhi-Tao Jiang, Wen-Zheng Ju
This study aimed to investigate the effect of Jiaotai Pills on protein expression in the hippocampus of the rat model of chronic unpredictable mild stress(CUMS)-induced depression by quantitative proteomics and explore the anti-depression mechanism of Jiaotai Pills. The SD rats were randomized into control, model, Jiaotai Pills, and fluoxetine groups(n=8). Other groups except the control group were subjected to CUMS modeling for 4 weeks. After 4 weeks of continuous administration, the changes of behavior and pathological morphology of the hippocampal tissue were observed...
December 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38197884/gray-mold-disease-on-bottle-gourd-caused-by-cladosporium-tenuissimum-in-china
#38
JOURNAL ARTICLE
JiangTao Hu, Jinglong Fu, Jingyan Zhang, Qian Song, Ying Zhou, Qi Liu, Lingli Ge, Qihan Zhu, SuMei Luo, Lingchang Xiao, Chuihui Xiong
Bottle gourd [Lagenaria siceraria (Mol.) Stand] is a widely cultivated succulent crop species. In December 2022, a serious bottle gourd disease occurred in the protected vegetable planting base of Xingguo County, Ganzhou City, Jiangxi Province, China, with 85% of the 2,100 plants having gray mold disease-like symptoms, including gray spots on the infected fruit. They quickly expanded at suitable temperature and humidity, forming a gray mold layer with inward depressions, which spread to the fruit stem causing watery rot, and the flesh turned black and started to rot...
January 10, 2024: Plant Disease
https://read.qxmd.com/read/38194947/ptov1-as1-desensitizes-colorectal-cancer-cells-to-5-fu-through-depressing-mir-149-5p-to-activate-the-positive-feedback-loop-with-wnt-%C3%AE-catenin-pathway
#39
JOURNAL ARTICLE
Yanan Chen, Xiaobei Mao, Yichen Xu, Lin Li, Jian Geng, Tingting Dai, Qian Wang, Lijun Xue, Leilei Tao, Xiaobei Liu
5-Fluorouracil is a commonly used chemotherapy drug for colorectal cancer. Resistance to 5-Fluorouracil remains a challenge. This research aimed to explore the mechanism of 5-Fluorouracil resistance in colorectal cancer. RT-qPCR and Western blot were used to determine the RNA and protein expression in both cells and exosome. Assays in vitro and in vivo were performed to measure the role of miR-149-5p in colorectal cancer cells. RIP, luciferase activity report, and RNA pulldown assay were applied to detect the association of PTOV1-AS1, SUV39H1, miR-149-5p, and FOXM1...
January 9, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38185260/phytomedicine-fructus-aurantii-derived-two-absorbed-compounds-unlock-antidepressant-and-prokinetic-multi-functions-via-modulating-5-ht-3-ghsr
#40
JOURNAL ARTICLE
Qiulong Zhao, Jin Liu, Li Chen, Zhao Gao, Muhai Lin, Yun Wang, Zhe Xiao, Yi Chen, Xi Huang
ETHNOPHARMACOLOGICAL RELEVANCE: Fructus Aurantii (FA), a well-known phytomedicine, has been employed to evoke antidepressant and prokinetic multi-functions. Therein, systematically identifying bioactive components and the referred mechanism is essential for FA. AIM OF THE STUDY: This study was planned to answer "2 W" (What and Why), such as which components and pathways contribute to FA's multi-functions. We aimed to identify bioactive compounds as the key for opening the lock of FA's multi-functions, and the molecule mechanisms are their naturally matched lock cylinder...
January 5, 2024: Journal of Ethnopharmacology
keyword
keyword
96000
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.