Andrew Waye, Malar Annal, Andrew Tang, Gabriel Picard, Frédéric Harnois, José A Guerrero-Analco, Ammar Saleem, L Mark Hewitt, Craig B Milestone, Deborah L MacLatchy, Vance L Trudeau, John T Arnason
Pulp and paper wood feedstocks have been previously implicated as a source of chemicals with the ability to interact with or disrupt key neuroendocrine endpoints important in the control of reproduction. We tested nine Canadian conifers commonly used in pulp and paper production as well as 16 phytochemicals that have been observed in various pulp and paper mill effluent streams for their ability to interact in vitro with the enzymes monoamine oxidase (MAO), glutamic acid decarboxylase (GAD), and GABA-transaminase (GABA-T), and bind to the benzodiazepine-binding site of the GABA(A) receptor (GABA(A)-BZD)...
January 15, 2014: Science of the Total Environment