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https://www.readbyqxmd.com/read/29221734/aortic-annulus-does-not-dilate-over-time-after-aortic-root-remodeling-with-or-without-annuloplasty
#1
Takashi Kunihara, Satoshi Arimura, Fumihiro Sata, Christian Giebels, Ulrich Schneider, Hans-Joachim Schäfers
OBJECTIVE: The lack of annular stabilization is the drawback of aortic root remodeling, and recently the addition of annuloplasty has been proposed. Limited data, however, exist on late annular size after remodeling. We studied annular size over time. METHODS: In 241 patients (53 ± 16 years) annular size was determined preoperatively (T0), before discharge (T1), and at least 2 years after remodeling (T2, 54 ± 27 months) with (n = 52) or without external suture annuloplasty...
December 5, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29221290/should-sinus-of-valsalva-be-preserved-in-patients-with-bicuspid-aortic-valve-and-aortic-dilation
#2
Yulin Wang, Yi Lin, Kanhua Yin, Kai Zhu, Zhaohua Yang, Yongxin Sun, Hao Lai, Chunsheng Wang
Background: It is recommended that dilated ascending aortas (≥45 mm) should be replaced at the time of aortic valve replacement (AVR) for bicuspid aortic valve (BAV). The risk of progressive sinus of Valsalva dilatation after AVR and ascending aorta replacement is less clear. Methods: We identified 156 patients (age 56.2±10.8 years, 46 females) who underwent AVR and ascending aorta replacement in our institution from 2010-2014, 124 (79%) of whom had BAV. Aortic root and ascending aorta sizes were determined from preoperative and the most recent echocardiograms...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29214469/four-leaf-clover-like-bicuspid-aortic-valve-visualized-by-two-dimensional-thoracic-and-three-dimensional-transesophageal-echocardiography
#3
Kiyoko Yoshizumi, Eiji Yamashita, Hiroki Okaniwa, Tomomi Araseki, Mihoka Iwazaki, Yasuyuki Kobayashi, Hiroyuki Toide
No abstract text is available yet for this article.
December 6, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/29206322/4d-flow-mri-cardiac-function-and-t1-mapping-association-of-valve-mediated-changes-in-aortic-hemodynamics-with-left-ventricular-remodeling
#4
Julia Geiger, Amir A Rahsepar, Kenichiro Suwa, Alex Powell, Ahmadreza Ghasemiesfe, Alex J Barker, Jeremy D Collins, James C Carr, Michael Markl
BACKGROUND: Patients with bicuspid aortic valve (BAV) show altered hemodynamics in the ascending aorta that can be assessed by 4D flow MRI. PURPOSE: Comprehensive cardiac MRI was applied to test the hypothesis that BAV-mediated changes in aortic hemodynamics (wall shear stress [WSS] and velocity) are associated with parameters of left ventricular (LV) remodeling. STUDY TYPE: Retrospective data analysis. POPULATION: Forty-nine BAV patients (mean age = 50...
December 5, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29204794/thoracic-aortic-aneurysm-unlocking-the-silent-killer-secrets
#5
Ayman A Saeyeldin, Camilo A Velasquez, Syed Usman B Mahmood, Adam J Brownstein, Mohammad A Zafar, Bulat A Ziganshin, John A Elefteriades
Thoracic aortic aneurysm (TAA) is an increasingly recognized condition that is often diagnosed incidentally. This review discusses ten of the most relevant epidemiological and clinical secrets of this disease; (1) the difference in pathogenesis between ascending and descending TAAs. TAAs at these two sites act as different diseases, which is related to the different embryologic origins of the ascending and descending aorta. (2) The familial pattern and genetics of thoracic aneurysms. Syndromic TAAs only explain 5% of the pattern of inheritance...
December 4, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29198801/bicuspid-aortic-valve-associated-aortopathy-a-slowly-evolving-picture
#6
EDITORIAL
Christian D Etz, Michael A Borger
No abstract text is available yet for this article.
November 29, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29198631/elective-david-i-procedure-has-excellent-long-term-results-20-year-single-center-experience
#7
Malakh L Shrestha, Erik Beckmann, Firas Abd Alhadi, Heike Krueger, Fiona Meyer-Bockenkamp, Sebastian Bertele, Nurbol Koigeldiyev, Tim Kaufeld, Felix Fleissner, Wilhelm Korte, Jan Schmitto, Serghei Cebotari, Wolfgang Harringer, Axel Haverich, Andreas Martens
BACKGROUND: We present our results after elective, isolated David I procedures over the past 20 years. METHODS: Between 1993 and 2015, 197 patients (mean age 46 ± 17 years, 73% men) underwent isolated aortic valve reimplantation using straight tube grafts (David I procedure). Sixty patients (31%) had Marfan syndrome, and 24 (12%) had a bicuspid aortic valve. Twenty-four patients (12%) were operated through upper mini-sternotomy. RESULTS: There were no perioperative deaths...
December 1, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29191731/characteristic-morphologies-of-the-bicuspid-aortic-valve-in-patients-with-genetic-syndromes
#8
Talha Niaz, Joseph T Poterucha, Timothy M Olson, Jonathan N Johnson, Cecilia Craviari, Thomas Nienaber, Jared Palfreeman, Frank Cetta, Donald J Hagler
BACKGROUND: In patients with bicuspid aortic valve (BAV), complications including progressive aortic stenosis and aortic dilatation develop over time. The morphology of cusp fusion is one of the determinants of the type and severity of these complications. We present the association of morphology of cusp fusion in BAV patients with distinctive genetic syndromes. METHODS: The Mayo Clinic echocardiography database was retrospectively reviewed to identify patients (age ≤ 22 years) diagnosed with BAV from 1990 to 2016...
November 28, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29189934/mechanical-deformation-in-adult-patients-with-unrepaired-aortic-coarctation
#9
Leonel Avendaño-Pérez, María Elena Soto, Nydia Ávila-Vanzzini, Guillermo Bracamontes-Castelo, José Carlos Ruán-Díaz, Erick Alexanderson-Rosas, Nilda Espinola-Zavaleta
Aortic coarctation is a congenital heart disease that causes an increased left ventricular afterload, resulting in increased systolic parietal tension, compensatory hypertrophy, and left ventricular systolic and diastolic dysfunction. The speckle tracking is a new echocardiographic technique that allows the detection of subclinic left ventricular systolic dysfunction. The aim of this study was to detect early left ventricular dysfunction using mechanical deformation by echocardiography in adults with un-repaired aortic coarctation...
November 30, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29188316/impact-of-bicuspid-aortic-valve-morphology-on-aortic-valve-disease-and-aortic-dilation-in-pediatric-patients
#10
Rebekah M Ward, Jordan M Marsh, Jeffrey M Gossett, Mallikarjuna R Rettiganti, R Thomas Collins
Bicuspid aortic valve (BAV) is the most common congenital heart defect. BAV is associated with aortic stenosis and insufficiency, and aortic dilation in adult groups, but data in pediatric groups are limited. We sought to assess the impact of BAV morphology on aortic valve disease and aortic dilation in pediatric patients. We performed a retrospective review of all echocardiograms in patients with isolated BAV who were followed at our institution from July 2002 to July 2012. BAV morphology, aortic valve stenosis and/or insufficiency, and aortic dimensions were measured manually...
November 29, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29176317/downregulated-microrna-195-in-the-bicuspid-aortic-valve-promotes-calcification-of-valve-interstitial-cells-via-targeting-smad7
#11
Junjie Du, Rui Zheng, Feng Xiao, Shuai Zhang, Keshuai He, Junjie Zhang, Yongfeng Shao
BACKGROUND/AIMS: Aortic stenosis caused by leaflet calcification in the bicuspid aortic valve (BAV) is more accelerative than that in the tricuspid aortic valve (TAV). MicroRNA-195 (miR-195) is downregulated more in stenotic than in insufficient BAVs, but its expression in BAVs compared with TAVs is unclear. We aimed to investigate the roles of miR-195 and its calcification-related target SMAD7 in stenotic BAVs compared with those in TAVs. METHODS: Twenty-one stenotic BAV and 29 TAV samples were collected from surgical patients and examined for the expression of miR-195 and SMAD7 by RT-PCR...
November 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29174327/a-case-of-cardiac-arrest-associated-with-aortic-valve-regurgitation
#12
Hyun Suk Chai, Suk Woo Lee, Jung Soo Park, Sang Chul Kim, Ji Han Lee, Hoon Kim
Blunt chest trauma can cause not only damage to the thoracic cage, but can also injure intracardiac structures including the papillary muscles, chordae tendineae, and valve leaflets. Aortic valve (AV) injury secondary to blunt chest trauma is a rare occurrence. Clinically, AV injury may be missed during the initial post-trauma assessment due to the lack of suspicion of cardiac involvement. Thus, the diagnosis of AV injury is often delayed or missed for a time interval of days to months. As a consequence, the traumatic AV regurgitation can rapidly or progressively lead to congestive heart failure unless surgically corrected...
November 20, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29171200/clinical-characteristics-of-korean-patients-with-bicuspid-aortic-valve-who-underwent-aortic-valve-surgery
#13
Byung Joo Sun, Xin Jin, Jae Kwan Song, Sahmin Lee, Ji Hye Lee, Jun Bean Park, Seung Pyo Lee, Dae Hee Kim, Sung Ji Park, Yong Jin Kim, Goo Yeong Cho, Jong Min Song, Duk Hyun Kang, Dae Won Sohn
BACKGROUND AND OBJECTIVES: Clinical data for Korean patients with bicuspid aortic valve (BAV) that underwent aortic valve (AV) surgery are currently limited. METHODS: Data for 1,160 consecutive adult BAV patients who underwent AV surgery from 2000 to 2014 in 4 tertiary referral centers were retrospectively analyzed. A standard Case Reports form was used for clinical and echocardiographic parameters. RESULTS: Mean age at the time of AV surgery was 59±13 years...
November 10, 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29169750/bicuspid-aortic-valve-a-complex-aortopathy-rather-than-a-simple-valvulopathy
#14
EDITORIAL
Guido Gelpi, Claudia Romagnoni
No abstract text is available yet for this article.
January 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29169748/ascending-aortic-size-in-aortic-coarctation-depends-on-aortic-valve-morphology-understanding-the-bicuspid-valve-phenotype
#15
Erik L Frandsen, Luke J Burchill, Abigail M Khan, Craig S Broberg
BACKGROUND: In roughly half of patients with coarctation of the aorta (CoA), the aorta may be enlarged. It is uncertain whether enlargement is independent of aortic valve morphology. We sought to compare aortic size in CoA with a tricuspid valve (TAV) to those with bicuspid aortic valve (BAV). METHODS: Sixty-eight CoA patients and 20 healthy controls with prior cardiac magnetic resonance (CMR) imaging were included. CMR was retrospectively reanalyzed to measure aortic root and mid-ascending aorta...
January 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29165337/mirnome-profiling-in-bicuspid-aortic-valve-associated-aortopathy-by-next-generation-sequencing
#16
Andrea Borghini, Ilenia Foffa, Silvia Pulignani, Cecilia Vecoli, Lamia Ait-Ali, Maria Grazia Andreassi
The molecular mechanisms underlying thoracic aortic aneurysm (TAA) in patients with bicuspid aortic valve (BAV) are incompletely characterized. MicroRNAs (miRNAs) may play a major role in the different pathogenesis of aortopathy. We sought to employ next-generation sequencing to analyze the entire miRNome in TAA tissue from patients with BAV and tricuspid aortic valve (TAV). In the discovery stage, small RNA sequencing was performed using the Illumina MiSeq platform in 13 TAA tissue samples (seven patients with BAV and six with TAV)...
November 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29163189/commentary-managing-thoracic-aortic-aneurysm-in-patients-with-bicuspid-aortic-valve-based-on-aortic-root-involvement
#17
COMMENT
Marco Russo, Paolo Nardi, Guglielmo Saitto, Fabio Bertoldo, Giovanni Ruvolo
No abstract text is available yet for this article.
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162281/targeted-next-generation-sequencing-identified-adamts5-as-novel-genetic-substrate-in-patients-with-bicuspid-aortic-valve
#18
Xiaoping Lin, Xianbao Liu, Lihan Wang, Jubo Jiang, Yinghao Sun, Qifeng Zhu, Zexin Chen, Yuxin He, Po Hu, Qiyuan Xu, Feng Gao, Yan Lin, Sanjay Jaiswal, Meixiang Xiang, Jian'an Wang
BACKGROUND: Bicuspid Aortic Valve (BAV) is the most common congenital heart disease, affecting >1% of the general population. Up to date, three genes, NOTCH1, GATA5 and SMAD6, have been linked to the isolated form of BAV. However, potential genetic determinants remain largely unknown in most BAV patients. MATERIAL AND METHODS: Targeted next-generation sequencing of 7 BAV candidate genes (NOTCH1, GATA5, SMAD6, NOS3, ADAMTS5, Alk2 and SMAD2) was performed in 32 BAV patients...
November 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29158447/krox20-defines-a-subpopulation-of-cardiac-neural-crest-cells-contributing-to-arterial-valves-and-bicuspid-aortic-valve
#19
Gaëlle Odelin, Emilie Faure, Fanny Coulpier, Maria Di Bonito, Fanny Bajolle, Michèle Studer, Jean-François Avierinos, Patrick Charnay, Piotr Topilko, Stéphane Zaffran
Although cardiac neural crest cells are required at early stages of arterial valve development, their contribution during valvular leaflet maturation remains poorly understood. Here we show in mouse that neural crest cells from pre-otic and post-otic regions make distinct contributions to the arterial valve leaflets. Genetic fate-mapping analysis of neural crest Krox20-expressing cells reveals a large contribution to the borders and the interleaflet triangles of the arterial valves. Loss of Krox20 function results in hyperplastic aortic valve and partially penetrant bicuspid aortic valve formation...
November 20, 2017: Development
https://www.readbyqxmd.com/read/29158034/different-notch-signaling-in-cells-from-calcified-bicuspid-and-tricuspid-aortic-valves
#20
A Kostina, A Shishkova, E Ignatieva, O Irtyuga, M Bogdanova, K Levchuk, A Golovkin, E Zhiduleva, V Uspenskiy, O Moiseeva, G Faggian, J Vaage, A Kostareva, A Rutkovskiy, A Malashicheva
AIMS: Calcific aortic valve disease is the most common heart valve disease in the Western world. Bicuspid and tricuspid aortic valve calcifications are traditionally considered together although the dynamics of the disease progression is different between the two groups of patients. Notch signaling is critical for bicuspid valve development and NOTCH1 mutations are associated with bicuspid valve and calcification. We hypothesized that Notch-dependent mechanisms of valve mineralization might be different in the two groups...
November 17, 2017: Journal of Molecular and Cellular Cardiology
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