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https://www.readbyqxmd.com/read/29042101/machine-learning-phenotypic-classification-of-bicuspid-aortopathy
#1
Charles M Wojnarski, Eric E Roselli, Jay J Idrees, Yuanjia Zhu, Theresa A Carnes, Ashley M Lowry, Patrick H Collier, Brian Griffin, John Ehrlinger, Eugene H Blackstone, Lars G Svensson, Bruce W Lytle
BACKGROUND: Bicuspid aortic valves (BAV) are associated with incompletely characterized aortopathy. Our objectives were to identify distinct patterns of aortopathy using machine-learning methods and characterize their association with valve morphology and patient characteristics. METHODS: We analyzed preoperative 3-dimensional computed tomography reconstructions for 656 patients with BAV undergoing ascending aorta surgery between January 2002 and January 2014. Unsupervised partitioning around medoids was used to cluster aortic dimensions...
September 14, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29033042/ascending-aortopathy-with-bicuspid-aortic-valve-individualizing-the-threshold
#2
EDITORIAL
Vincent R Conti, Abe DeAnda
No abstract text is available yet for this article.
September 22, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29029085/impairment-of-elastic-properties-of-the-aorta-in-bicuspid-aortic-valve-relationship-between-biomolecular-and-aortic-strain-patterns
#3
Luca Longobardo, Maria Ludovica Carerj, Gabriele Pizzino, Alessandra Bitto, Maurizio Cusma Piccione, Marta Zucco, Lilia Oreto, Maria Chiara Todaro, Maria Pia Calabrò, Francesco Squadrito, Gianluca Di Bella, Giuseppe Oreto, Bijoy K Khandheria, Scipione Carerj, Concetta Zito
Aims: Bicuspid aortic valve (BAV) is associated with aortic wall alterations. We aimed to detect any correlation between aortic elasticity and genetic and biomolecular patterns of elastin. Methods and results: Forty-nine BAV patients (mean age: 38 ± 17.05) were prospectively enrolled. A blood sample was drawn for analysis of a single nucleotide polymorphism of elastin gene (ELN rs2071307) responsible for misfolding of elastin, and for the amount of elastin soluble fragments (ESF) in the plasma...
September 23, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29029058/inter-ethnic-differences-in-valve-morphology-valvular-dysfunction-and-aortopathy-between-asian-and-european-patients-with-bicuspid-aortic-valve
#4
William K F Kong, Madelien V Regeer, Kian K Poh, James W Yip, Philippe J van Rosendael, Tiong C Yeo, Edgar Tay, Vasileios Kamperidis, Enno T van der Velde, Bart Mertens, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
Background: Transcatheter aortic valve replacement (TAVR) has been shown safe and feasible in patients with bicuspid aortic valve (BAV) morphology. Evaluation of inter-ethnic differences in valve morphology and function and aortic root dimensions in patients with BAV is important for the worldwide spread of this therapy in this subgroup of patients. Comparisons between large European and Asian cohorts of patients with BAV have not been performed, and potential differences between populations may have important implications for TAVR...
October 6, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29029050/small-sized-conduits-in-the-right-ventricular-outflow-tract-in-young-children-bicuspidalized-homografts-are-a-good-alternative-to-standard-conduits
#5
Katrien François, Katya De Groote, Kristof Vandekerckhove, Hans De Wilde, Daniel De Wolf, Thierry Bové
OBJECTIVES: Downsizing a homograft (HG) through bicuspidalization has been used for more than 2 decades to overcome the shortage of small-sized conduits for reconstruction of the right ventricular outflow tract (RVOT) in young children. Our goal was to investigate the durability of bicuspidalized HGs compared with other small HGs. METHODS: A retrospective analysis of 93 conduits ≤20 mm, implanted over 23 years, was performed. The end-points were survival, structural valve degeneration and conduit replacement...
October 3, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29029001/comparative-study-of-bicuspid-vs-tricuspid-aortic-valve-stenosis
#6
Geoffrey D Huntley, Jeremy J Thaden, Said Alsidawi, Hector I Michelena, Joseph J Maleszewski, William D Edwards, Christopher G Scott, Sorin V Pislaru, Patricia A Pellikka, Kevin L Greason, Naser M Ammash, Joseph F Malouf, Maurice Enriquez-Sarano, Vuyisile T Nkomo
Aims: To examine differences and similarities in bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) stenosis occurring during the same age and whether any differences impact outcomes following aortic valve replacement (AVR). Methods and results: An age-matched cohort of 198 BAV stenosis and 198 TAV stenosis patients was identified from 888 consecutive patients undergoing AVR for severe AS. Mean age 68 ± 6 years; 68% male. Patients with BAV were less likely to have multiple comorbidities, as measured by the Charlson Comorbidity Index (CCI) >2 (3 vs...
October 3, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29017405/outcomes-of-transcatheter-aortic-valve-replacement-for-bicuspid-aortic-stenosis-a-systematic-review-of-existing-literature
#7
Samir V Patel, Rajesh Sonani, Vikas Singh, Palak Patel, Apurva Badheka
Patients with bicuspid aortic valve (BAV) have traditionally been excluded from large randomized clinical trials involving transcatheter aortic valve replacements (TAVR). Technical enhancements, availability of new generation devices and improved outcomes have led to a marked increase in TAVR volume across the world including off label use in patients with BAV stenosis. Areas covered: In this manuscript, we have reviewed the currently available data regarding safety, efficacy, and outcomes of TAVR in patients with BAV stenosis...
October 10, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28993736/pathogenic-mechanisms-of-bicuspid-aortic-valve-aortopathy
#8
REVIEW
Noor M Yassine, Jasmine T Shahram, Simon C Body
Bicuspid aortic valve (BAV) is the most common congenital valvular defect and is associated with ascending aortic dilation (AAD) in a quarter of patients. AAD has been ascribed both to the hemodynamic consequences of normally functioning and abnormal BAV morphology, and to the effect of rare and common genetic variation upon function of the ascending aortic media. AAD manifests in two overall and sometimes overlapping phenotypes: that of aortic root aneurysm, similar to the AAD of Marfan syndrome; and that of tubular AAD, similar to the AAD seen with tricuspid aortic valves (TAVs)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28987740/longer-term-results-z-scores-and-decision-nomograms-for-treatment-of-the-ascending-aorta-in-1693-bicuspid-aortic-valve-operations
#9
Hans-Hinrich Sievers, Sina Stock, Ulrich Stierle, Stefan Klotz, Efstratios I Charitos, Michael Diwoky, Doreen Richardt
OBJECTIVE: This study aims to fine-tune the decision making for ascending aorta treatment in bicuspid aortic valve surgery. METHODS: A total of 1693 patients with a primary indication for aortic valve surgery were investigated retrospectively with respect to a multifactorial decision-making policy including the z score and the clinical outcome in relation to different techniques for ascending aorta treatment (no intervention n = 1116; intervention n = 577 either by ascending aorta replacement n = 404 or aortoplasty n = 173)...
September 14, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28987279/long-term-evaluation-of-the-ross-procedure-in-acute-infective-endocarditis
#10
Thomas Ratschiller, Sames-Dolzer Eva, Patrick Paulus, Wolfgang Schimetta, Hannes Müller, Andreas F Zierer, Rudolf Mair
OBJECTIVE: Optimal valve substitute for young patients with aortic valve endocarditis remains controversial. Given its better resistance to infection, the Ross procedure is an attractive alternative to prosthetic valve replacement or homograft implantation. The objective of this study was to assess long-term outcomes of the Ross procedure in this indication. METHODS: From 01/1991 to 04/2017, 190 patients underwent a Ross procedure at our institution. Acute endocarditis was the indication for operation in 19 patients, including 6 patients with a bicuspid aortic valve...
October 5, 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28986054/reduced-aggrecan-expression-affects-cardiac-outflow-tract-development-in-zebrafish-and-is-associated-with-bicuspid-aortic-valve-disease-in-humans
#11
Pierre Rambeau, Emilie Faure, Alexis Théron, Jean-François Avierinos, Chris Jopling, Stéphane Zaffran, Adèle Faucherre
Hemodynamic forces have been known for a long time to regulate cardiogenic processes such as cardiac valve development. During embryonic development in vertebrates, the outflow tract (OFT) adjacent to the ventricle comes under increasing hemodynamic load as cardiogenesis proceeds. Consequently, extracellular matrix components are produced in this region as the cardiac cushions form which will eventually give rise to the aortic valves. The proteoglycan AGGRECAN is a key component of the aortic valves and is frequently found to be deregulated in a variety of aortic valve diseases...
September 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28983176/bentall-operation-in-a-patient-with-an-anomalous-left-circumflex-artery-case-report-and-review
#12
Ivo Gasparovic, Panagiotis Artemiou, Mikulas Kiss, Michal Hulman
Anomalous origin of a left circumflex artery from the right coronary sinus represents a technical challenge in patients who require aortic valve/root procedures. This case report describes a patient who presented with bicuspid aortic valve, anomalous origin of the circumflex artery, severe aortic regurgitation, and aneurysm of the ascending aorta as well as aortic root that was safely managed following the Bentall procedure with the combined button technique.
October 2017: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/28982503/clinical-outcomes-following-the-ross%C3%A2-procedure-in-adults-a-25-year-longitudinal-study
#13
Elisabeth Martin, Siamak Mohammadi, Frederic Jacques, Dimitri Kalavrouziotis, Pierre Voisine, Daniel Doyle, Jean Perron
BACKGROUND: Very few reports of long-term outcomes of patients who underwent the Ross procedure have been published. OBJECTIVES: The authors reviewed their 25-year experience with the Ross procedure with the aim of defining very-long-term survival and factors associated with Ross-related failure. METHODS: Between January 1990 and December 2014, the Ross procedure was performed in 310 adults (mean age 40.8 years) at a single institution. All patients were prospectively added to a dedicated cardiac surgery registry...
October 10, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28980342/3d-axial-and-circumferential-wall-shear-stress-from-4d-flow-mri-data-using-a-finite-element-method-and-a-laplacian-approach
#14
Julio Sotelo, Lydia Dux-Santoy, Andrea Guala, José Rodríguez-Palomares, Arturo Evangelista, Carlos Sing-Long, Jesús Urbina, Joaquín Mura, Daniel E Hurtado, Sergio Uribe
PURPOSE: To decompose the 3D wall shear stress (WSS) vector field into its axial (WSSA ) and circumferential (WSSC ) components using a Laplacian finite element approach. METHODS: We validated our method with in silico experiments involving different geometries and a modified Poiseuille flow. We computed 3D maps of the WSS, WSSA , and WSSC using 4D flow MRI data obtained from 10 volunteers and 10 patients with bicuspid aortic valve (BAV). We compared our method with the centerline method...
October 4, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28979899/complete-resolution-of-a-large-bicuspid-aortic-valve-thrombus-with-anticoagulation-in-primary-antiphospholipid-syndrome
#15
Rayan Jo Rachwan, Ghassan E Daher, Jawad Fares, Rachoin Rachoin
Native aortic valve thrombosis in primary antiphospholipid syndrome (APLS) is a rare entity. We describe a 38-year-old man who presented with neurological symptoms and a cardiac murmur. Transthoracic echocardiography detected a large bicuspid aortic valve thrombus. Laboratory evaluation showed the presence of antiphospholipid antibodies. Anticoagulation was started, and serial echocardiographic studies showed complete resolution of the aortic valve vegetation after 4 months. The patient improved clinically and had no residual symptoms...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28974934/corrigendum-candidate-gene-resequencing-in-a-large-bicuspid-aortic-valve-associated-thoracic-aortic-aneurysm-cohort-smad6-as-an-important-contributor
#16
Elisabeth Gillis, Ajay A Kumar, Ilse Luyckx, Christoph Preuss, Elyssa Cannaerts, Gerarda van de Beek, Björn Wieschendorf, Maaike Alaerts, Nikhita Bolar, Geert Vandeweyer, Josephina Meester, Florian Wünnemann, Russell A Gould, Rustam Zhurayev, Dmytro Zerbino, Salah A Mohamed, Seema Mital, Luc Mertens, Hanna M Björck, Anders Franco-Cereceda, Andrew S McCallion, Lut Van Laer, Judith M A Verhagen, Ingrid M B H van de Laar, Marja W Wessels, Emmanuel Messas, Guillaume Goudot, Michaela Nemcikova, Alice Krebsova, Marlies Kempers, Simone Salemink, Toon Duijnhouwer, Xavier Jeunemaitre, Juliette Albuisson, Per Eriksson, Gregor Andelfinger, Harry C Dietz, Aline Verstraeten, Bart L Loeys
[This corrects the article on p. 400 in vol. 8, PMID: 28659821.].
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28970802/characteristics-of-carotid-artery-structure-and-mechanical-function-and-their-relationships-with-aortopathy-in-patients-with-bicuspid-aortic-valves
#17
Mihyun Kim, Chi Young Shim, Seong-Chan You, In-Jeong Cho, Geu-Ru Hong, Jong-Won Ha, Namsik Chung
Patients with a bicuspid aortic valve (BAV) often have proximal aortic dilatation and systemic vascular dysfunction. We hypothesized that BAV patients would have different carotid artery structural and functional characteristics compared to tricuspid aortic valve (TAV) patients. In 28 patients with surgically confirmed BAV and 27 patients with TAV, intima media thickness (IMT), number of plaques, fractional area change (FAC), global circumferential strain (GCS), and standard deviation of CS (SD-CS) in both common carotid arteries were assessed using duplex ultrasound and velocity vector imaging (VVI)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28966455/combined-mitral-and-aortic-valve-stenosis-caused-by-two-different-etiologies-rheumatic-and-congenital
#18
William C Roberts, Joshua K Dodderer
Described herein are five patients who had double left-sided cardiac valve replacement for mitral and aortic valve stenosis resulting from two different etiologies: rheumatic heart disease, the cause of the mitral stenosis, and congenital heart disease (bicuspid valve), the underlying cause of the aortic stenosis.
October 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28963771/transcatheter-aortic-valve-replacement-for-stenotic-bicuspid-aortic-valves-systematic-review-and-meta-analyses-of-observational-studies
#19
Gautam Reddy, Zhen Wang, Rick A Nishimura, Kevin L Greason, Sung-Han Yoon, Raj R Makkar, David R Holmes
OBJECTIVE: The aim of this study was to perform a systematic review and meta-analyses of observational studies of transcatheter aortic valve replacement (TAVR) for bicuspid aortic valve stenosis (BcAV). BACKGROUND: TAVR for BcAV stenosis has been associated with an increased incidence of paravalvular leaks, valve malposition, pacemaker placement and all-cause mortality. The conclusions drawn have been limited by small sample sizes. The use of TAVR for BcAV stenosis remains controversial...
September 30, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28962499/valve-sparing-aortic-root-replacement-in-a-bicuspid-aortic-valve-with-papillary-fibroelastoma
#20
Stoyan Kondov, Fabian Alexander Kari, Martin Czerny, Matthias Siepe
We present our surgical strategy in a patient with a bicuspid aortic valve Type I (R/N), aortic root aneurysm and papillary fibroelastoma on the aortic valve's cusp. He underwent valve-sparing aortic root replacement (David V Procedure); we also removed the papillary fibroelastoma from the fused right- and non-coronary cusp. In this case, we used a 34-mm straight Dacron graft for root replacement and an aortic annulus downsized to 30 mm. We use Hegar dilatators for the intraoperative measurement of the aortic annulus...
October 1, 2017: Interactive Cardiovascular and Thoracic Surgery
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