keyword
https://read.qxmd.com/read/38497457/prognostic-implications-of-left-atrial-strain-in-bicuspid-aortic-valve-with-chronic-aortic-regurgitation
#1
JOURNAL ARTICLE
YuTing Tan, YuMan Li, WenHui Deng, RuiZe Zhang, RuoHan Zhao, Abudukadier Abulipizi, Jing Zhang, Xiang Ji, QuanFei Hou, Tianshu Liu, Lingyun Fang, Li Zhang, MingXing Xie, Jing Wang
BACKGROUND: Left atrial reservoir strain (LARS) is a novel imaging biomarker of left ventricular diastolic dysfunction. This study aimed to examine the prognostic implications of LARS in patients with bicuspid aortic valve and significant (moderate-severe to severe) aortic regurgitation. METHODS AND RESULTS: A total of 220 patients with bicuspid aortic valve and significant aortic regurgitation were prospectively enrolled in our study. LARS and left ventricular global longitudinal strain were derived from speckle-tracking echocardiography...
March 18, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38490941/utilising-pyrophosphate-uptake-imaging-to-establish-the-timing-of-acute-myocardial-infarction-an-often-forgotten-art
#2
Jeremy J Russo, Bonnia Liu, Jeffrey Lefkovits, Nathan Better
INTRODUCTION: While pyrophosphate uptake imaging with Technetium-99 m pyrophosphate (Tc-99 m PYP) is frequently used for cardiac ATTR amyloid imaging, its role in determining the timing of acute myocardial infarction (AMI) is near forgotten. We present a case that demonstrates the clinical benefit of pyrophosphate uptake imaging in differentiating recent from remote infarction as a reminder of the continued utility of pyrophosphate uptake imaging for this indication. CASE AND OUTCOMES: A 68-year-old male was referred for surgical replacement of his bicuspid aortic valve with severe aortic regurgitation...
March 14, 2024: Journal of Medical Imaging and Radiation Sciences
https://read.qxmd.com/read/38481442/evaluating-the-relationship-between-the-proportion-of-x-chromosome-deletions-and-clinical-manifestations-in-children-with-turner-syndrome
#3
JOURNAL ARTICLE
Gaowei Wang, Xiaojing Liu, Meiye Wang, Jin Wang, Zhenhua Zhang, Karel Allegaert, Daoqi Mei, Yaodong Zhang, Shuying Luo, Yang Fang, Dongxiao Li, Yongxing Chen, Haiyan Wei
PURPOSE: Analyze the relationship between changes in the proportion of X-chromosome deletions and clinical manifestations in children with Turner syndrome (TS). METHODS: X-chromosome number abnormalities in 8,635 children with growth retardation were identified using fluorescence in situ hybridization (FISH). Meanwhile, the relationship between the proportion of X-chromosome deletions and the clinical manifestations of TS, such as face and body phenotype, cardiovascular, renal, and other comorbidities in children with TS was analyzed...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38480086/selective-placement-of-novel-compression-suture-technique-to-reduce-pacemaker-implantation-rate-following-surgical-aortic-valve-replacement-with-rapid-deployment-intuity-valve
#4
JOURNAL ARTICLE
Kelvin Jeason Yang, Chih-Hsien Wang, Hsiao-En Tsai, Sheng-Pin Yu, Yih-Sharng Chen, Nai-Hsin Chi
OBJECTIVE: The use of RDV in SAVR is associated with risk of conduction abnormality requiring PPM implantation, when compared to conventional bioprosthetic valves. We aimed to evaluate the outcome after selective placement of annular compression sutures during surgical aortic valve replacement (SAVR) using Intuity rapid deployment valve (RDV). METHODS: This is a retrospective study of prospectively enrolled patients receiving SAVR using Intuity RDV. Selective placement of commissural compression suture was assessed for all patients based on their annular morphology...
March 12, 2024: Journal of the Formosan Medical Association
https://read.qxmd.com/read/38478089/aortic-regurgitation-is-associated-with-african-american-and-asian-race-smoking-renal-disease-and-numerous-autoimmune-diseases-in-addition-to-traditional-cardiovascular-risk-factors%C3%A2-but-has%C3%A2-lower-risk-with-alcohol-intake
#5
JOURNAL ARTICLE
Brandon Timmerman, Mehrtash Hashemzadeh, Mohammad Reza Movahed
BACKGROUND: Aortic regurgitation (AR) is associated with increasing age, rheumatic heart disease, and a bicuspid aortic valve, but its association with other comorbidities and race is less known. The purpose of this study was to investigate any association between AR and comorbid conditions in older adults above 40. METHOD: The large Nationwide Inpatient Sample database was utilized for our study using uni- and multivariate analysis. Data were extracted from available ICD-10 codes for the years of 2016-2020...
March 13, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38478047/morphology-clinical-associations-and-pathologic-follow-up-of-quadricuspid-aortic-valves-in-children
#6
JOURNAL ARTICLE
Omotola Ajayi, Faraz Alizadeh, Sepehr Sekhavat, Kristin Bonello, Rebecca S Beroukhim, Sunil J Ghelani
While quadricuspid morphology is commonly observed in truncal valves, quadricuspid aortic valves (QAV) are rare and their natural history is not well described. This retrospective study of 37 patients describes the diagnostic associations and morphologic variability of QAVs in children (median age at diagnosis 4.3 y IQR 0-12 y). Associated congenital heart diseases were present in 54% (most commonly tetralogy of Fallot (TOF) and valvar pulmonary stenosis). Among patients with isolated QAV, 11 had genetic syndrome and 5 had skeletal anomalies...
March 13, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38473887/mirna-regulation-of-cell-phenotype-and-parietal-remodeling-in-atherosclerotic-and-non-atherosclerotic-aortic-aneurysms-differences-and-similarities
#7
REVIEW
Sonia Terriaca, Amedeo Ferlosio, Maria Giovanna Scioli, Francesca Coppa, Fabio Bertoldo, Calogera Pisano, Beatrice Belmonte, Carmela Rita Balistreri, Augusto Orlandi
Aortic aneurysms are a serious health concern as their rupture leads to high morbidity and mortality. Abdominal aortic aneurysms (AAAs) and thoracic aortic aneurysms (TAAs) exhibit differences and similarities in their pathophysiological and pathogenetic features. AAA is a multifactorial disease, mainly associated with atherosclerosis, characterized by a relevant inflammatory response and calcification. TAA is rarely associated with atherosclerosis and in some cases is associated with genetic mutations such as Marfan syndrome (MFS) and bicuspid aortic valve (BAV)...
February 24, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38471650/outcomes-for-patients-undergoing-transcatheter-aortic-valve-replacement-with-ascending-aorta-dilation
#8
JOURNAL ARTICLE
Dejing Feng, Jie Zhao, Guannan Niu, Yuxuan Zhang, Can Wang, Yang Chen, Zheng Zhou, Hongliang Zhang, Zhenyan Zhao, Yunqing Ye, Zhe Li, Haiyan Xu, Moyang Wang, Yongjian Wu
BACKGROUND: We aim to compare the short and long-term outcomes for aortic stenosis (AS) patients undergone TAVR with and without ascending aorta dilation (AAD). METHODS: Consecutive patients diagnosed with native severe AS who underwent TAVR from September 2012 to September 2021 were enrolled. They were stratified into the moderate/severe dilation group (greatest ascending aorta width ≥ 45 mm) and the non/mild dilation group. Survival outcomes were illustrated using Kaplan-Meier curves and evaluated with the log-rank test...
March 10, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38471156/virtual-reality-to-predict-paravalvular-leak-in-bicuspid-severe-aortic-valve-stenosis-in-transcatheter-aortic-valve-implants
#9
JOURNAL ARTICLE
Johnny Chahine, Lorraine Mascarenhas, Demetris Yannopoulos, Ganesh Raveendran, Sergey Gurevich
OBJECTIVES: Severe aortic stenosis (AS) in bicuspid aortic valves (BAV) is associated with an increased risk of paravalvular leak (PVL) after a transcatheter aortic valve replacement (TAVR). Virtual reality (VR) has been shown to be an effective tool in surgical training, but its utility in clinical practice has not been studied. Here we present the first study to evaluate the use of VR simulation in pre-procedure planning and prediction of PVL in TAVR in patients with severe BAV AS. METHODS: Twenty-two patients with severe BAV AS undergoing TAVR between 2014 and 2018 at the University of Minnesota were included in the study...
March 11, 2024: Journal of Invasive Cardiology
https://read.qxmd.com/read/38458510/axillary-vs-femoral-arterial-cannulation-in-acute-type-a-dissection-international-multicenter-data
#10
JOURNAL ARTICLE
Malak Elbatarny, Santi Trimarchi, Amit Korach, Marco Di Eusanio, Davide Pacini, Raffi Bekeredjian, Truls Myrmel, Joseph E Bavaria, Nimesh D Desai, Ibrahim Sultan, Derek R Brinster, Chih-Wen Pai, Kim A Eagle, Himanshu J Patel, Mark D Peterson
BACKGROUND: Cannulation strategy in acute Type A dissection (ATAD) varies widely without known gold standards. We compared ATAD outcomes of Axillary versus Femoral cannulation in a large cohort from the International Registry of Acute Aortic Dissection (IRAD). METHODS: We retrospectively reviewed 2145 IRAD Interventional Cohort patients (1996-2021) undergoing ATAD repair with axillary or femoral cannulation (Axillary: N=1106, 52%; Femoral: N=1039, 48%). Endpoints included: early mortality; neurologic, respiratory and renal complications; malperfusion; and tamponade...
March 6, 2024: Annals of Thoracic Surgery
https://read.qxmd.com/read/38457932/patient-specific-analysis-of-bicuspid-aortic-valve-hemodynamics-using-a-fully-coupled-fluid-structure-interaction-model
#11
JOURNAL ARTICLE
Tongran Qin, Wenbin Mao, Andrés Caballero, Norihiko Kamioka, Stamatios Lerakis, Santiago Lain, John Elefteriades, Liang Liang, Wei Sun
Bicuspid aortic valve (BAV), the most common congenital heart disease, is prone to develop significant valvular dysfunction and aortic wall abnormalities such as ascending aortic aneurysm. Growing evidence has suggested that abnormal BAV hemodynamics could contribute to disease progression. In order to investigate BAV hemodynamics, we performed 3D patient-specific fluid-structure interaction (FSI) simulations with fully coupled blood flow dynamics and valve motion throughout the cardiac cycle. Results showed that the hemodynamics during systole can be characterized by a systolic jet and two counter-rotating recirculation vortices...
February 19, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38456972/thoracic-aortic-microcalcification-activity-in-combined-positron-emission-tomography-and-magnetic-resonance-imaging
#12
JOURNAL ARTICLE
Jennifer Nash, Samuel Debono, Beth Whittington, Jakub Kaczynski, Tim Clark, Gillian Macnaught, Scott Semple, Edwin J R van Beek, Adriana Tavares, Damini Dey, Michelle C Williams, Piotr J Slomka, David E Newby, Marc R Dweck, Alexander J Fletcher
INTRODUCTION: Non-invasive detection of pathological changes in thoracic aortic disease remains an unmet clinical need particularly for patients with congenital heart disease. Positron emission tomography combined with magnetic resonance imaging (PET-MRI) could provide a valuable low-radiation method of aortic surveillance in high-risk groups. Quantification of aortic microcalcification activity using sodium [18 F]fluoride holds promise in the assessment of thoracic aortopathies. We sought to evaluate aortic sodium [18 F]fluoride uptake in PET-MRI using three methods of attenuation correction compared to positron emission tomography computed tomography (PET-CT) in patients with bicuspid aortic valve, METHODS: Thirty asymptomatic patients under surveillance for bicuspid aortic valve disease underwent sodium [18 F]fluoride PET-CT and PET-MRI of the ascending thoracic aorta during a single visit...
March 8, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38426608/multiyear-interval-changes-in-aortic-wall-shear-stress-in-patients-with-bicuspid-aortic-valve-assessed-by-4d-flow-mri
#13
JOURNAL ARTICLE
Anthony Maroun, Michael B Scott, Roberta Catania, Haben Berhane, Kelly Jarvis, Bradley D Allen, Alex J Barker, Michael Markl
BACKGROUND: In patients with bicuspid aortic valve (BAV), 4D flow MRI can quantify regions exposed to abnormal aortic hemodynamics, including high wall shear stress (WSS), a known stimulus for arterial wall dysfunction. However, the long-term multiscan reproducibility of 4D flow MRI-derived hemodynamic parameters is unknown. PURPOSE: To investigate the long-term stability of 4D flow MRI-derived peak velocity, WSS, and WSS-derived heatmaps in patients with BAV undergoing multiyear surveillance imaging...
March 1, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38423848/safety-and-effectiveness-of-the-novel-myval-octacor-transcatheter-heart-valve-in-severe-symptomatic-aortic-valve-stenosis-a-real-world-indian-experience-the-octacor-india-study
#14
JOURNAL ARTICLE
John Jose, Asishkumar Mandalay, Manjunath N Cholenahally, Ravindranath S Khandenahally, Srinivas C Budnur, Maulik Parekh, Ravinder S Rao, Ashok Seth, Praveen Chandra, Rajneesh Kapoor, Praveer Agarwal, Atul Mathur, Vijay Kumar, Sadananda S Kanchanahalli, Ajith S Mullasari, Vijayakumar Subban, Uday B Khanolkar, Sanjay Mehrotra, Manik Chopra, Rajendra K Jain, Haresh Mehta, Rahul Gupta, Viveka Kumar, Bagirath Raghuraman, Naman Shastri, Hesham Elzomor, Osama Soliman, Sengottuvelu Gunasekaran
PURPOSE: To evaluate the safety and effectiveness of the novel, next-generation Myval Octacor - Transcatheter Heart Valve (THV) in patients with severe, symptomatic, native aortic stenosis (AS). METHODS: This multicenter, real-world observational registry included 123 patients with severe symptomatic AS, across 16 Indian centers who underwent treatment with the novel Myval Octacor THV. Study endpoints included all-cause mortality, all stroke, acute kidney injury (AKI), major vascular complications, moderate or severe paravalvular leakage (PVL) and new permanent pacemaker implantation (PPI) until 30 days follow-up...
January 28, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38422504/universal-fetal-echocardiography-for-pregestational-diabetes-mellitus-a-cost-effectiveness-analysis
#15
JOURNAL ARTICLE
Leah M Savitsky, Caitlin Hamilton, Mary Sterrett, Kelsey Olerich, Kimberly Ma, Catherine M Albright
OBJECTIVE: To evaluate the cost effectiveness of universal fetal echocardiogram for patients with pregestational diabetes mellitus by first-trimester hemoglobin A1c (Hb A1c) level. METHODS: We developed a cost-effectiveness model comparing two strategies of screening for critical fetal congenital heart disease among patients with diabetes: universal fetal echocardiogram and fetal echocardiogram only after abnormal findings on detailed anatomy ultrasonogram. We excluded ventricular septal defect, atrial septal defects, and bicuspid aortic valve from the definition of critical fetal congenital heart disease...
February 29, 2024: Obstetrics and Gynecology
https://read.qxmd.com/read/38421105/de-novo-variants-predicting-haploinsufficiency-for-dip2c-are-associated-with-expressive-speech-delay
#16
JOURNAL ARTICLE
Thoa Ha, Angela Morgan, Meghan N Bartos, Katelyn Beatty, Benjamin Cogné, Dominique Braun, Céline B Gerber, Harald Gaspar, Anna M Kopps, Claudine Rieubland, Anna C E Hurst, David J Amor, Mathilde Nizon, Laurent Pasquier, Rolph Pfundt, André Reis, Victoria Mok Siu, Marine Tessarech, Michelle L Thompson, Marie Vincent, Bert B A de Vries, Matthew B Walsh, Stephanie Burns Wechsler, Christiane Zweier, Rhonda E Schnur, Maria J Guillen Sacoto, Henri Margot, Barbara Masotto, Maria Irene Valenzuela Palafoll, Urwah Nawaz, Irina Voineagu, Anne Slavotinek
The disconnected (disco)-interacting protein 2 (DIP2) gene was first identified in D. melanogaster and contains a DNA methyltransferase-associated protein 1 (DMAP1) binding domain, Acyl-CoA synthetase domain and AMP-binding sites. DIP2 regulates axonal bifurcation of the mushroom body neurons in D. melanogaster and is required for axonal regeneration in the neurons of C. elegans. The DIP2 homologues in vertebrates, Disco-interacting protein 2 homolog A (DIP2A), Disco-interacting protein 2 homolog B (DIP2B), and Disco-interacting protein 2 homolog C (DIP2C), are highly conserved and expressed widely in the central nervous system...
February 29, 2024: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/38419169/effect-of-deletion-of-the-protein-kinase-prkd1-on-development-of-the-mouse-embryonic-heart
#17
JOURNAL ARTICLE
Qazi Waheed-Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Marc-Phillip Hitz, Gregor Dombrowsky, Friederike Cuello, J David Brook, Siobhan Loughna
Congenital heart disease (CHD) is the most common congenital anomaly, with an overall incidence of approximately 1% in the United Kingdom. Exome sequencing in large CHD cohorts has been performed to provide insights into the genetic aetiology of CHD. This includes a study of 1891 probands by our group in collaboration with others, which identified three novel genes-CDK13, PRKD1, and CHD4, in patients with syndromic CHD. PRKD1 encodes a serine/threonine protein kinase, which is important in a variety of fundamental cellular functions...
February 28, 2024: Journal of Anatomy
https://read.qxmd.com/read/38410558/transcatheter-aortic-valve-replacement-in-the-treatment-of-bicuspid-aortic-stenosis-with-down-size-interventional-valves-procedural-and-mid-term-follow-up
#18
JOURNAL ARTICLE
Kun Liu, Kaisheng Wu, Jinglun Shen, Fei Meng, Francesco Nappi, Fernando Alfonso, Shengxun Wang, Shuai Zheng, Haibo Zhang
BACKGROUND: Due to the influence of anatomical structure, replacing the bicuspid valve using transcatheter aortic valve replacement (TAVR) would increase the risk of perivalvular leakage and conduction block, affecting the hemodynamic effect of the interventional valve. In this study, for bicuspid and tricuspid valves, we implemented different valve selection strategies to explore the safety and effectiveness of TAVR in the treatment of bicuspid aortic stenosis with "down-size" interventional valves using the VenusA-valve system...
January 30, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38410556/enhanced-expression-of-neopterin-in-valve-tissue-of-bicuspid-aortic-stenosis
#19
JOURNAL ARTICLE
Goki Inno, Yosuke Takahashi, Takahiko Naruko, Yoshiki Matsumura, Yukio Abe, Takanobu Aoyama, Akimasa Morisaki, Kenta Nishiya, Makiko Ueda, Toshihiko Shibata
BACKGROUND: Aortic valve stenosis (AS) occurs in bicuspid aortic valve (BAV) patients at a relatively young age compared to tricuspid aortic valve (TAV) patients. However, the underlying cause of this phenomenon remains unknown. Neopterin, which is a by-product of the guanosine triphosphate (GTP) pathway, enhances the oxidative potential of reactive oxygen species. To clarify the role of neopterin in the aortic valve, we immunohistochemically studied the presence of neopterin in aortic valve specimens from patients with AS harboring either TAV or BAV...
January 30, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38404628/navigating-the-challenges-of-bicuspid-aortic-valve-aortopathy
#20
REVIEW
Sai Gautham Kanagala, Aanchal Sawhney, Kinna Parikh, Vasu Gupta, Talha Mahmood, Fnu Anamika, Rohit Jain, Nikita Garg
Bicuspid aortic valve (BAV) is a congenital heart defect that affects 0.5-2% of the general population with familial predominance. The modifications in hemodynamics and structure change at cellular level contribute to the dilation of aorta, resulting in bicuspid aortopathy, which can result in catastrophic aortic events. The American Heart Association recommends screening first-degree relatives of patients with bicuspid aortic valve and aortic root disease. BAV may or may not be associated with a syndrome, with the non-syndromic variety having a higher chance of predisposition to congenital and vascular abnormalities...
September 30, 2023: Global Cardiology Science & Practice
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