Thoa Ha, Angela Morgan, Meghan N Bartos, Katelyn Beatty, Benjamin Cogné, Dominique Braun, Céline B Gerber, Harald Gaspar, Anna M Kopps, Claudine Rieubland, Anna C E Hurst, David J Amor, Mathilde Nizon, Laurent Pasquier, Rolph Pfundt, André Reis, Victoria Mok Siu, Marine Tessarech, Michelle L Thompson, Marie Vincent, Bert B A de Vries, Matthew B Walsh, Stephanie Burns Wechsler, Christiane Zweier, Rhonda E Schnur, Maria J Guillen Sacoto, Henri Margot, Barbara Masotto, Maria Irene Valenzuela Palafoll, Urwah Nawaz, Irina Voineagu, Anne Slavotinek
The disconnected (disco)-interacting protein 2 (DIP2) gene was first identified in D. melanogaster and contains a DNA methyltransferase-associated protein 1 (DMAP1) binding domain, Acyl-CoA synthetase domain and AMP-binding sites. DIP2 regulates axonal bifurcation of the mushroom body neurons in D. melanogaster and is required for axonal regeneration in the neurons of C. elegans. The DIP2 homologues in vertebrates, Disco-interacting protein 2 homolog A (DIP2A), Disco-interacting protein 2 homolog B (DIP2B), and Disco-interacting protein 2 homolog C (DIP2C), are highly conserved and expressed widely in the central nervous system...
February 29, 2024: American Journal of Medical Genetics. Part A