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https://www.readbyqxmd.com/read/28514193/90-90-90-plus-maintaining-adherence-to-antiretroviral-therapies
#1
Inge B Corless, Alex J Hoyt, Lynda Tyer-Viola, Elizabeth Sefcik, Jeanne Kemppainen, William L Holzemer, Lucille Sanzero Eller, Kathleen Nokes, J Craig Phillips, Carol Dawson-Rose, Marta Rivero-Mendez, Scholastika Iipinge, Puangtip Chaiphibalsarisdi, Carmen J Portillo, Wei-Ti Chen, Allison R Webel, John Brion, Mallory O Johnson, Joachim Voss, Mary Jane Hamilton, Kathleen M Sullivan, Kenn M Kirksey, Patrice K Nicholas
Medication adherence is the "Plus" in the global challenge to have 90% of HIV-infected individuals tested, 90% of those who are HIV positive treated, and 90% of those treated achieve an undetectable viral load. The latter indicates viral suppression, the goal for clinicians treating people living with HIV (PLWH). The comparative importance of different psychosocial scales in predicting the level of antiretroviral adherence, however, has been little studied. Using data from a cross-sectional study of medication adherence with an international convenience sample of 1811 PLWH, we categorized respondent medication adherence as None (0%), Low (1-60%), Moderate (61-94%), and High (95-100%) adherence based on self-report...
May 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28513200/hiv-infected-individuals-who-use-alcohol-and-other-drugs-and-virologic-suppression
#2
Seonaid Nolan, Alexander Y Walley, Timothy C Herren, Gregory J Patts, Alicia S Ventura, Meg M Sullivan, Jeffrey H Samet, Richard Saitz
People living with HIV (PLWH) on antiretroviral therapy (ART) who use substances were examined to (a) describe those with virologic control and (b) determine which substance use-factors are associated with lack of virologic control. Participants were adult PLWH taking ART with either past 12-month DSM-IV substance dependence or past 30-day alcohol or illicit drug use. Substance use factors included number of DSM-IV alcohol or drug dependence criteria and past 30-day specific substance use. Associations with HIV viral load (HVL) (<200 vs...
May 17, 2017: AIDS Care
https://www.readbyqxmd.com/read/28508665/prevalence-of-and-risk-factors-for-depressive-symptoms-among-people-living-with-hiv-aids-receiving-antiretroviral-treatment-in-wuhan-china-a-short-report
#3
Hu Rong, Xie Nianhua, Xu Jun, Ruan Lianguo, Wu Si, Wei Sheng, Guo Heng, Wang Xia
We aimed to explore the prevalence of and risk factors for depressive symptoms (DS) among people living with HIV/AIDS (PLWHA) receiving antiretroviral treatment (ART) in Wuhan, Hubei, China. A cross-sectional study evaluating adult PLWHA receiving ART in nine designated clinical hospitals was conducted from October to December 2015. The validated Beck Depression Inventory (BDI) was used to assess DS in eligible participants. Socio-demographical, epidemiological and clinical data were directly extracted from the case reporting database of the China HIV/AIDS Information Network...
May 16, 2017: AIDS Care
https://www.readbyqxmd.com/read/28507772/clinically-significant-depressive-symptoms-and-sexual-behaviour-among-men-who-have-sex-with-men
#4
Ada R Miltz, Alison J Rodger, Janey Sewell, Andrew Speakman, Andrew N Phillips, Lorraine Sherr, Richard J Gilson, David Asboe, Nneka C Nwokolo, Amanda Clarke, Mark M Gompels, Sris Allan, Simon Collins, Fiona C Lampe
BACKGROUND: The relationship between depression and sexual behaviour among men who have sex with men (MSM) is poorly understood. AIMS: To investigate prevalence and correlates of depressive symptoms (Patient Health Questionnaire-9 score ≥10) and the relationship between depressive symptoms and sexual behaviour among MSM reporting recent sex. METHOD: The Attitudes to and Understanding of Risk of Acquisition of HIV (AURAH) is a cross-sectional study of UK genitourinary medicine clinic attendees without diagnosed HIV (2013-2014)...
May 2017: BJPsych Open
https://www.readbyqxmd.com/read/28504307/family-based-promotion-of-mental-health-in-children-affected-by-hiv-a-pilot-randomized-controlled-trial
#5
Theresa S Betancourt, Lauren C Ng, Catherine M Kirk, Robert T Brennan, William R Beardslee, Sara Stulac, Christine Mushashi, Estella Nduwimana, Sylvere Mukunzi, Beatha Nyirandagijimana, Godfrey Kalisa, Cyamatare F Rwabukwisi, Vincent Sezibera
BACKGROUND: Children affected by HIV are at risk for poor mental health. We conducted a pilot randomized controlled trial (RCT) of the Family Strengthening Intervention (FSI-HIV), a family home-visiting intervention to promote mental health and improve parent-child relationships in families with caregivers living with HIV, hypothesizing that child and family outcomes would be superior to usual care social work services. METHODS: Eighty two families (N = 170 children, 48...
May 15, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28498278/depression-and-survival-in-a-17-year-longitudinal-study-of-people-with-hiv-moderating-effects-of-race-and-education
#6
Gail Ironson, Calvin Fitch, Rick Stuetzle
OBJECTIVE: The prevalence of clinically significant depressive symptoms is 3 times higher in people living with HIV (PLWH) than in the general population. While studies have shown that depression predicts worse course with HIV, few have investigated its relationship with mortality, and none have had a 17-year follow-up period and been conducted entirely during the time since the advent of protease inhibitors. METHODS: We followed a diverse sample of HIV positive people (n=177) in the mid-range of illness for a study on stress and coping...
May 12, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28498011/factors-associated-with-antiretroviral-therapy-adherence-among-transgender-women-receiving-hiv-medical-care-in-the-united-states
#7
Yuko Mizuno, Linda Beer, Ping Huang, Emma L Frazier
PURPOSE: We examined factors associated with antiretroviral therapy (ART) adherence among transgender women living with HIV (TWLWH). METHODS: We used combined data from the 2009 to 2013 cycles of Medical Monitoring Project, an HIV surveillance system designed to produce nationally representative estimates of the characteristics of HIV-infected adults receiving HIV medical care in the United States. Rao-Scott chi-square tests and multivariable logistic regression were used to identify factors associated with dose adherence (defined as taking 100% of prescribed ART doses in the past 3 days)...
May 12, 2017: LGBT Health
https://www.readbyqxmd.com/read/28492085/self-managing-hiv-aids-cultural-competence-and-health-among-women-in-nairobi-kenya
#8
Toni Copeland
Despite recent efforts to supply antiretroviral therapy, many in Africa are not receiving medication, instead relying on self-management in their attempts to remain healthy. In Kenya, the majority of those infected are women who are below the extreme poverty level. Building on research demonstrating a link between knowledge of HIV/AIDS management and the length of time HIV-positive women have lived in Nairobi, this article uses a cognitive anthropological approach that conceives of culture as shared models and explores the relationship between how well women know a cultural model of self-managing HIV/AIDS and health among women who are not receiving biomedical treatment...
May 11, 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/28491869/prevalence-and-associated-factors-of-suicidal-ideation-and-attempt-among-people-living-with-hiv-aids-at-zewditu-memorial-hospital-addis-ababa-ethiopia-a-cross-sectional-study
#9
Etsay Hailu Gebremariam, Mebratu Mitiku Reta, Zebiba Nasir, Fisseha Zewdu Amdie
Background. Human Immune Deficiency Virus (HIV/AIDS) continues to be an underrecognized risk for suicidal ideation, suicidal attempt, and completion of suicide. Suicidal ideation and attempt in HIV/AIDS is not only a predictor of future attempted suicide and completed suicide. Methods. An institution based cross-sectional study was conducted among HIV-positive patients attending HIV care at Zewditu Memorial Hospital. Systematic random sampling technique was used to recruit 423 participants from April to May 2014...
2017: Psychiatry Journal
https://www.readbyqxmd.com/read/28490832/gender-differences-in-depressive-symptoms-among-hiv-positive-concordant-and-discordant-heterosexual-couples-in-china
#10
Li Li, Li-Jung Liang, Chunqing Lin, Guoping Ji, Yongkang Xiao
HIV seropositive individuals and their heterosexual partners/spouses, either seropositive or seronegative, are facing several mental health challenges. The objective of this study was to examine gender differences in depressive symptoms among HIV-positive concordant and HIV-discordant couples. We identified heterosexual couples from participants of a randomized controlled trial conducted in Anhui province, China. A total of 265 couples, comprising 129 HIV+ male/HIV- female couples, 98 HIV- male/HIV+ female couples, and 38 HIV-positive concordant couples, were included in the analyses...
March 2017: Psychology of Women Quarterly
https://www.readbyqxmd.com/read/28490237/phytochemistry-and-pharmacological-activities-of-the-genus-swertia-gentianaceae-a-review
#11
Jie Li, Yan-Li Zhao, Heng-Yu Huang, Yuan-Zhong Wang
Swertia plants have been considered to be medicinal plants useful for the treatment of various ailments for thousands of years, especially in Asian countries. This is due to the broad variety of chemical compounds that provide multiple ligands for bonding to different endogenous biomacromolecules for patients. Chemical constituents and pharmacological activities of Swertia plants are summarized in this paper. Approximately 419 metabolites and 40 bioactive compounds have been reported from 30 Swertia species, including xanthones, flavonoids, seco-iridiods, iridiods, triterpenoids, alkaloids, volatiles, and other secondary metabolites...
May 11, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28488886/network-support-technology-use-depression-and-art-adherence-among-hiv-positive-msm-of-color
#12
I W Holloway, D Tan, S L Dunlap, L Palmer, S Beougher, J A Cederbaum
Depression is associated with poor antiretroviral therapy (ART) adherence among people living with HIV/AIDS. This relationship may be moderated by an individual's social network characteristics. Our study sought to examine social network correlates of treatment adherence among HIV-positive men recruited from social service agencies throughout Los Angeles County (N = 150) to inform technology-driven social support interventions for this population. We administered egocentric social network and computer-assisted survey interviews focused on demographic characteristics, health history, depressive symptoms, and ART adherence, where adherence was assessed by the number of reasons participants missed taking their medication, if ever...
May 10, 2017: AIDS Care
https://www.readbyqxmd.com/read/28484888/depression-and-anxiety-are-common-in-acute-hiv-infection-and-associate-with-plasma-immune-activation
#13
Joanna Hellmuth, Donn Colby, Victor Valcour, Duanghathai Suttichom, Serena Spudich, Jintanat Ananworanich, Peeriya Prueksakaew, Napapon Sailasuta, Isabel Allen, Linda L Jagodzinski, Bonnie Slike, Derek Ochi, Robert Paul
This observational study of 123 Thai participants sought to determine the rate and severity of affective symptoms during acute HIV infection (AHI) and possible associations to disease mechanisms. At diagnosis, just prior to starting combination antiretroviral therapy (cART), AHI participants completed assessments of depression and anxiety symptoms that were repeated at 4, 12, and 24 weeks. Blood markers of HIV infection and immune activation were measured at study entry, with optional cerebrospinal fluid measures...
May 8, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28482927/the-developmental-effects-of-hiv-and-alcohol-a-comparison-of-gestational-outcomes-among-babies-from-south-african-communities-with-high-prevalence-of-hiv-and-alcohol-use
#14
Kirsten A M Donald, Anne Fernandez, Kasey Claborn, Caroline Kuo, Nastassja Koen, Heather Zar, Dan J Stein
BACKGROUND: There is growing evidence of the negative impact of alcohol on morbidity and mortality of individuals living with HIV but limited evidence of in utero effects of HIV and alcohol on exposure on infants. METHODS: We conducted a population-based birth cohort study (N = 667 mother-infant dyads) in South Africa to investigate whether maternal alcohol use and HIV affected gestational outcomes. Descriptive data analysis was conducted for all variables using frequency distributions, measures of central tendency, and estimates of variance...
May 8, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28480240/a-high-prevalence-rate-of-a-positive-screen-for-cognitive-impairment-in-patients-with-human-immunodeficiency-virus-attending-an-irish-clinic
#15
Patricia H McNamara, Robert Coen, Janice Redmond, Colin P Doherty, Colm Bergin
BACKGROUND: Human immunodeficiency virus (HIV)-associated neurocognitive disorders occurs in 20%-50% of HIV-positive patients. We undertook this study to assess the prevalence of a positive screen for cognitive impairment in the clinic population at our institution and to demonstrate the feasibility of implementing a screening program in routine clinical encounters. METHODS: This was a cross-sectional study, and patients were recruited prospectively between December 2010 and February 2013...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28479896/prevalence-of-suicidal-ideation-and-attempt-associations-with-psychiatric-disorders-and-hiv-aids-in-post-conflict-northern-uganda
#16
James Mugisha, Herbert Muyinda, Ashraf Kagee, Peter Wandiembe, Stephen Kiwuwa Mpugu, Davy Vancampfort, Eugene Kinyanda
BACKGROUND: Research on the prevalence of suicidal ideation, attempt, and cormorbid psychiatric disorders in post-conflict areas is still limited. AIM: We explored the prevalence of suicidal ideation, attempt, associated psychiatric disorders and HIV/AIDS in post-conflict Northern Uganda, an area that experienced civil strife for over two decades. METHODS: A total of 2400 respondents (aged 18 and above) and randomly selected in three districts (Gulu, Amuru and Nwoya), were interviewed...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28478716/effect-of-valerian-in-preventing-neuropsychiatric-adverse-effects-of-efavirenz-in-hiv-positive-patients-a-pilot-randomized-placebo-controlled-clinical-trial
#17
Motahareh Ahmadi, Hossein Khalili, Ladan Abbasian, Padideh Ghaeli
BACKGROUND: Several neuropsychiatric adverse effects of efavirenz are known. Preventing these adverse effects may improve patients' adherence to antiretroviral therapy (ART). OBJECTIVES: To evaluate the efficacy and safety of valerian in preventing neuropsychiatric adverse effects of efavirenz in HIV-positive patients. METHOD: In this pilot randomized, double-blinded, placebo-controlled, clinical trial, 51 HIV-positive patients who were receiving efavirenz were recruited into the valerian (n = 25) or placebo (n = 26) group...
June 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28478706/interest-in-use-of-mhealth-technology-in-hiv-prevention-and-associated-factors-among-high-risk-drug-users-enrolled-in-methadone-maintenance-program
#18
Roman Shrestha, Pramila Karki, Michael Copenhaver
The adoption of mobile technologies for health (mHealth) in healthcare has grown considerably in recent years, but systematic assessment of interest in the use of mHealth in HIV prevention efforts among people who use drugs (PWUD) is lacking. We therefore examined interest in use of mHealth technology in HIV prevention and associated individual-level factors among high-risk PWUD enrolled in methadone maintenance program. A total of 400 HIV-negative PWUD, who reported drug- and/or sex-related risk behaviors completed a standardized assessment using audio computer assisted self-interview (ACASI)...
May 8, 2017: AIDS Care
https://www.readbyqxmd.com/read/28473182/quality-of-life-among-women-living-with-hiv-in-rural-india
#19
Adeline M Nyamathi, Maria Ekstrand, Kartik Yadav, Padma Ramakrishna, Elsa Heylen, Catherine Carpenter, Sarah Wall, Tanya Oleskowicz, Lenore Arab, Sanjeev Sinha
A cross-sectional examination was conducted on quality of life (QOL) among women living with HIV (WLWH) in rural Andhra Pradesh, India. Baseline data were collected from 400 WLWH and their children. QOL was measured with 10 items from the Quality of Life Enjoyment and Satisfaction Questionnaire. Findings revealed low QOL scores; on a scale from 0 to 3, the mean QOL score was 0.38 (SD = 0.30). Depression symptoms were reported by 25.5%, internalized stigma was high, and most reported little to no social support...
March 24, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28471947/measuring-and-managing-cognitive-impairment-in-hiv
#20
Sam Nightingale, Alan Winston
: Cognitive impairment remains a frequently reported complaint in HIV-positive patients despite virologically suppressive antiretroviral therapy. Rates of cognitive impairment in antiretroviral treated HIV-positive cohorts vary and strongly depend on definitions utilized.The underlying pathogenesis is likely to be multifactorial and includes immune activation, neuroinflammation, antiretroviral neurotoxicity, the presence of noninfectious comorbidities such as vascular disease and depression and patient lifestyle factors such as recreational drug use...
June 1, 2017: AIDS
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