Mia Marie Pries-Heje, Julie Glud Hjulmand, Ingrid Try Lenz, Rasmus Bo Hasselbalch, Jonas Agerlund Povlsen, Nikolaj Ihlemann, Nana Køber, Marlene Lyngborg Tofterup, Lauge Østergaard, Morten Dalsgaard, Daniel Faurholt-Jepsen, Malene Wienberg, Ulrik Christiansen, Niels Eske Bruun, Emil Fosbøl, Claus Moser, Kasper Karmark Iversen, Henning Bundgaard
BACKGROUND AND AIMS: In the Partial Oral Treatment of Endocarditis (POET) trial, stabilized patients with left-sided infective endocarditis (IE) were randomized to oral step-down antibiotic therapy (PO) or conventional continued intravenous antibiotic treatment (IV), showing non-inferiority after 6 months. In this study, the first guideline-driven clinical implementation of the oral step-down POET regimen was examined. METHODS: Patients with IE, caused by Staphylococcus aureus, Enterococcus faecalis, Streptococcus spp...
December 21, 2023: European Heart Journal