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Endocarditis enterococcus

Khandakar Hussain, Saad Ullah, Hassan Tahir, Waseem Zaid Alkilani, Muhammad Naeem, Nagadarshini Ramagiri Vinod, Samuel Massoud
Multidrug-resistant enterococcal nosocomial invasive infections are a rising concern faced by the medical community. Not many options are available to treat these highly virulent organisms. Risk factors for developing these highly resistant organisms include prolonged hospital stay, previous antibiotic use, and immunosuppression. In this article, we report a case of daptomycin-resistant enterococcal native infective endocarditis treated with off-label use of quinupristin-dalfopristin.
July 2016: Journal of Investigative Medicine High Impact Case Reports
Bart Peeters, Paul Herijgers, Kurt Beuselinck, Willy E Peetermans, Marie-Christin Herregods, Stefanie Desmet, Katrien Lagrou
Identification of the causative pathogen of infective endocarditis is crucial for adequate management and therapy. A broad range PCR/electrospray ionization mass spectrometry (PCR/ESI-MS) technique was compared with broad-spectrum 16S rRNA PCR and amplicon sequencing (16S rRNA PCR) for detecting bacterial pathogens in 40 heart valves obtained from 34 definite infective endocarditis patients according to the modified Duke Criteria and six non-endocarditis patients. Concordance between both molecular techniques was 98% for being positive or negative, 97% for concordant identification up to genus level and 77% for concordant identification up to species level...
September 14, 2016: Journal of Clinical Microbiology
Kamelia M Osman, Mohamed N Ali, Ismail Radwan, Fatma ElHofy, Ahmed H Abed, Ahmed Orabi, Nehal M Fawzy
Although normally regarded harmless commensals, enterococci may cause a range of different infections in humans, including urinary tract infections, sepsis, and endocarditis. The acquisition of vancomycin resistance by enterococci (VRE) has seriously affected the treatment and infection control of these organisms. VRE are frequently resistant to all antibiotics that are effective treatment for vancomycin-susceptible enterococci, which leaves clinicians treating VRE infections with limited therapeutic options...
2016: Frontiers in Microbiology
Alkesh Zala, Nicholas Collins
No abstract text is available yet for this article.
October 2016: Heart, Lung & Circulation
Hafeez Ul Hassan Virk, Faisal Inayat, Salman Farooq, Ali Raza Ghani, Ghazi A Mirrani, Muhammed Waqas Athar
CONTEXT: Coronary embolization is potentially a fatal sequela of endocarditis. Although the primary cause of acute coronary syndrome is atherosclerotic disease, it is imperative to consider septic embolism as an etiological factor. CASE REPORT: Herein, we report a case of ventricular fibrillation and ST-segment depression myocardial infarction occurring in a patient who initially presented with fever and increased urinary frequency. Coronary angiography revealed new 99% occlusion of the left main coronary artery (LMCA)...
June 2016: North American Journal of Medical Sciences
A Kornberger, B Luchting, F Kur, M Weis, F Weis, U A Stock, A Beiras-Fernandez
BACKGROUND: Infection is a main cause of morbidity and mortality after heart surgery, with multi-resistant pathogens increasingly representing a challenge. Daptomycin provides bactericidal activity against gram-positive organisms that are resistant to standard treatment including vancomycin. METHODS: A cohort of cardiac surgical patients, treated with daptomycin for major infection at two tertiary care centers, were retrospectively studied with a particular focus on the type of infection, causative pathogens and co-infections, daptomycin dosage, adverse events and outcome in order to provide evidence for the efficiency and safety of daptomycin in a distinct high-risk patient population...
2016: Journal of Cardiothoracic Surgery
Ester Castellsagué, Barbara Rivera, William D Foulkes
No abstract text is available yet for this article.
July 28, 2016: New England Journal of Medicine
Steven H Itzkowitz, David A Ahlquist
No abstract text is available yet for this article.
July 28, 2016: New England Journal of Medicine
Juan M Pericàs, Juan Corredoira, José M Miró
No abstract text is available yet for this article.
July 28, 2016: New England Journal of Medicine
Williamson B Strum
No abstract text is available yet for this article.
July 28, 2016: New England Journal of Medicine
Ana María Sánchez-Díaz, Beatriz Romero-Hernández, Elisa Conde-Moreno, Young-Keun Kwak, Javier Zamora, Patricia Colque-Navarro, Roland Möllby, Patricia Ruiz-Garbajosa, Rafael Cantón, Laura García-Bermejo, Rosa Del Campo
Enterococcus faecium and Streptococcus gallolyticus subsp. gallolyticus (S. gallolyticus) were classically clustered into the Lancefield Group D streptococci and despite their taxonomic reclassification still share a similar genetic content and environment. Both species are considered as opportunistic pathogens. E. faecium is often associated with nosocomial bacteraemia, and S. gallolyticus is sporadically found in endocarditis of colorectal cancer patients. In both cases, the source of infection is commonly endogenous with a translocation process that launches through the intestinal barrier...
2016: PloS One
Jun Hirai, Daisuke Sakanashi, Mao Hagihara, Shusaku Haranaga, Kohei Uechi, Hideo Kato, Hiroyuki Hamada, Naoya Nishiyama, Yusuke Koizumi, Hiroyuki Suematsu, Yuka Yamagishi, Jiro Fujita, Hiroshige Mikamo
Gene sequence analysis methods, including 16S rRNA identification, allows accurate identification of Streptococcus species, which include phenotypically closely related species that are difficult to differentiate using conventional chemical methods. We report a case of bacteremia due to Streptococcus tigurinus, identified by 16S rRNA, in a 72-year-old woman with gastrointestinal cancer and ascites. She was hospitalized to undergo elective tumor-related surgery. Five days prior to undergoing surgery, she developed a fever with no obvious source of infection...
July 23, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Amar Raj Mohee, Deborah Gascoyne-Binzi, Robert West, Selina Bhattarai, Ian Eardley, Jonathan A T Sandoe
The aim of this work was to investigate the microbial causes, incidence, duration, risk factors and clinical implications of bacteraemia occurring during transurethral resection of the prostate (TURP) surgery to better inform prophylaxis strategies. An ethically approved, prospective, cohort study of patients undergoing TURP was conducted. Clinical information and follow-up details were collected using standardized data collection sheets. Blood was obtained for culture at 6 different time points peri-procedure...
2016: PloS One
Yoshiki Hiyama, Satoshi Takahashi, Teruhisa Uehara, Koji Ichihara, Jiro Hashimoto, Naoya Masumori
We report a patient with infective endocarditis and pyrogenic spondylitis occurring simultaneously. The patient was a 59-year-old man. He was suspected of having prostate cancer due to a high prostate-specific antigen concentration noted in a checkup. He then underwent a transrectal ultrasound guided prostate biopsy with cefotiam as antimicrobial prophylaxis. He had a fever higher than 38 °C and lumbar pain for a few days after the biopsy. Enterococcus faecalis was isolated from 2 sets of blood culture. Magnetic resonance imaging revealed an abnormal image at C7/Th1 with a signal decrease in T1-weighted sequences and signal increase in T2-weighted sequences that were suspected to be due to bone destruction...
June 28, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Anders Dahl, Trine K Lauridsen, Magnus Arpi, Lars L Sørensen, Christian Østergaard, Peter Sogaard, Niels E Bruun
BACKGROUND: The NOVA score is a recently developed diagnostic tool used to identify patients with increased risk of infective endocarditis (IE) among patients with Enterococcus faecalis bacteremia. We aimed to validate the NOVA score and to identify risk factors for IE. METHODS: From 1 January 2010 to 31 December 2013, we included 647 consecutive patients with E. faecalis bacteremia. The NOVA score was used in a slightly adapted form; 2/2 positive blood cultures resulted in 5 points, unknown origin of infection in 4 points, prior valve disease in 2 points, and heart murmur in 1 point...
September 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Rajesh Janardhanan, Muhammad Umar Kamal, Irbaz Bin Riaz, M Cristy Smith
UNLABELLED: SummaryIn intravenous drug abusers, infective endocarditis usually involves right-sided valves, with Staphylococcus aureus being the most common etiologic agent. We present a patient who is an intravenous drug abuser with left-sided (aortic valve) endocarditis caused by Enterococcus faecalis who subsequently developed an anterior mitral valve aneurysm, which is an exceedingly rare complication. A systematic literature search was conducted which identified only five reported cases in the literature of mitral valve aneurysmal rupture in the setting of E...
March 2016: Echo Research and Practice
Sean I Tracy, Sherry-Ann Brown, John T Ratelle, Anjali Bhagra
A 59-year-old man was admitted with a 3-month history of daily fevers as well as bilateral knee pain and swelling. Medical history was significant for bilateral knee arthroplasties 4 years prior to admission. Two sets of peripheral blood cultures as well as bilateral knee synovial fluid grew Enterococcus faecalis within 10 hours. Transoesophageal echocardiography revealed aortic and mitral valve vegetations suggestive of infectious endocarditis, with severe regurgitation secondary to large size. The patient's hospitalisation was complicated by acute heart failure, necessitating emergent mitral valve repair and aortic valve replacement, followed shortly thereafter by bilateral total knee arthroplasty resection with placement of antibiotic spacers...
2016: BMJ Case Reports
Hassan Alkhawam, Robert Sogomonian, Feras Zaiem, Neil Vyas, Mohammed El-Hunjul, JoshPaul Jolly, Ahmed Al-Khazraji, Amar Ashraf
Infective endocarditis (IE) is a severe illness associated with significant morbidity and mortality. The primary purpose of this study was to evaluate morbidity and mortality of IE in a hospital serving the most diverse area in New York City. An analysis of 209 patients admitted to the hospital from 2000 to 2012 who were found to have IE based on modified Duke criteria. Among the 209 patients with IE, 188 (88.8%) had native heart valves and 21 (11.2%) had prosthetic valves. Of the patients with native heart valves, 3...
August 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Christiana T Vogkou, Nikolaos I Vlachogiannis, Leonidas Palaiodimos, Antonis A Kousoulis
Infective endocarditis (IE) incidence remains high with considerable fatality rates; guidelines for prophylaxis against IE are currently under review in some settings which highlights the importance of maintaining up-to-date epidemiological estimates about the most common microbial causes. The objective of this systematic review, following PRISMA guidelines, was to identify the most common microbial causes of IE in recent years. Medline was searched from January 1, 2003 to March 31, 2013 for all articles containing the term "infective endocarditis"...
August 2016: European Journal of Clinical Microbiology & Infectious Diseases
Luca Fallavollita, Lorena Di Gioacchino, Fabrizio Balestrini
Enterococci are common organisms associated with endocarditis, but infection by Enterococcus durans is very rare. To our knowledge, only 3 cases have been reported in the medical literature, and all 3 have involved native valves. Here we publish the first reported case (to our knowledge) of E. durans endocarditis in association with a bioprosthetic aortic valve. After the organism and its antibiotic susceptibility were identified, the 74-year-old male patient was treated successfully with teicoplanin and gentamicin, over a course of 6 weeks...
April 2016: Texas Heart Institute Journal
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