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https://www.readbyqxmd.com/read/28730999/surgery-for-benign-prostatic-hyperplasia-profile-of-patients-in-a-tertiary-care-institution
#1
Rahul Rajeev, Bhuwan Giri, Lok Prakash Choudhary, Rajeev Kumar
BACKGROUND: Medical therapy is widely used for managing benign prostatic hyperplasia (BPH) and has made an impact on the profile of patients who ultimately undergo surgery. This changing profile may impact outcomes of surgery and associated complications. To assess the impact of medical management, we evaluated the profile of patients who had surgery for BPH at our institution. METHODS: A retrospective chart-review was performed of patient demographics, indications for surgery, preoperative comorbid conditions and postoperative course in patients who underwent surgery for BPH over a 5-year period...
January 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28730787/association-of-ferritin-with-prostate-cancer
#2
Qiang Su, Ting Lei, Man Zhang
PURPOSE: Prostate specific antigen (PSA) has been widely used as the unique serum biomarker for the diagnosis and/ or pre-diagnosis of prostate cancer (PCa). However, the diagnostic value of PSA is a subject of ongoing debate owing to its lack of specificity, especially when the PSA level is moderately increased (e.g., 4-10 ng/ml). Thus, we suggest the need for identification of a new biomarker to discriminate PCa cases from benign prostatic hyperplasia (BPH) and normal controls (N). METHODS: Urine or tissue samples of PCa patients, BPH patients, and normal controls were systematically collected...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28730786/clinical-significance-of-microvessel-density-and-proliferation-in-prostate-cancer-core-biopsy
#3
Stevan D Matic, Milena S Rakocevic, Tomislav T Jocic, Milos S Todorovic, Ljiljana M Vuckovic, Snezana A Jancic, Milan G Knezevic
PURPOSE: To investigate the microvessel density (MVD) and proliferation in prostate cancer (PC) core biopsies. METHODS: Core biopsy samples of PC tissue from 45 patients were routinely processed and embedded in paraffin. The samples of PC formed the investigated group (n=25), while samples of benign prostatic hyperplasia (BPH) served as controls (n=20). From paraffin blocks, 3-5 μm-thick sections were made and routine hematoxylin-eosin method and immunohistochemical ABC method with Ki67 and CD34 antibodies were applied...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28727906/potential-of-telmisartan-in-the-treatment-of-benign-prostatic-hyperplasia
#4
Ismail Ogunbayode Ishola, Charles C Anunobi, Kehinde Habeeb Tijani, Olasunmbo Afolayan, Victoria U Udokwu
Benign prostatic hyperplasia (BPH) is a common health problem in aging men. This study was carried out to investigate the protective effect of telmisartan on testosterone induced-BPH in rats. Fifty-four male Wistar rats (200 - 250g) were randomly divided into 9 groups (n =6) and orally treated for 28 consecutive days: group 1- vehicle normal, olive oil (10 ml/kg); group 2- BPH model control (10 ml/kg); groups 3-5 - telmisartan (5, 10 or 20 mg/kg, respectively); group 6- pioglitazone (20 mg/kg); group 7- celecoxib (20 mg/kg); group 8- combination of telmisartan (5 mg/kg) and pioglitazone (20 mg/kg); group 9- combination of telmisartan (5 mg/kg) and celecoxib (20 mg/kg)...
July 20, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28725598/canine-prostate-models-in-preclinical-studies-of-minimally-invasive-interventions-part-ii-benign-prostatic-hyperplasia-models
#5
REVIEW
Fei Sun, Claudia Báez-Díaz, Francisco Miguel Sánchez-Margallo
Canine prostate is widely used as animal model in the preclinical evaluation of emerging therapeutic interventions. Spontaneous benign prostatic hyperplasia (BPH) is common in adult intact male dogs with two distinct pathological types: glandular and complex form of prostatic hyperplasia. The complex form of prostatic hyperplasia, usually occurring in older dogs, represents an ideal model because of its unique pathologic feature, including not only glandular hyperplasia but also an increase in prostate stromal components...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28723522/efficacy-and-safety-of-hexanic-lipidosterolic-extract-of-serenoa-repens-permixon-in-the-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
REVIEW
Giacomo Novara, Gianluca Giannarini, Antonio Alcaraz, José-M Cózar-Olmo, Aurelien Descazeaud, Francesco Montorsi, Vincenzo Ficarra
CONTEXT: A recent Cochrane Collaboration meta-analysis of randomized controlled trials (RCTs) evaluating the efficacy of different extracts of Serenoa repens in relieving lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) concluded that these extracts were no more effective than placebo. However, among all Serenoa repens extracts, Permixon (Pierre Fabre Medicament, Paris, France) has the highest activity and the most accurate standards of drug preparation and extraction...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28721283/stereological-comparison-of-intraprostatic-injection-of-alcohol-and-bleomycin-with-finasteride-gavages-in-rats
#7
Ali Eslahi, Ali Noorafshan, Ali-Reza Safarpour, Masood Sepehrimanesh, Ali Ariafara, Elham Nadimi
INTRODUCTION: Resection of the prostate is one of the standard surgical treatments for symptomatic Benign Prostatic Hyperplasia (BPH). To evaluate minimally invasive treatments, intraprostatic injections of ethanol and bleomycin were compared with oral finasteride administration in rats with BPH. MATERIAL AND METHODS: The rats were divided into six groups. The control rats received no BPH/no treatment. BPH was induced using injections of testosterone (2 mg/day/rat for 4 weeks) in groups II-VI...
June 30, 2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28721281/safety-and-efficacy-of-tamsulosin-alfuzosin-or-silodosin-as-monotherapy-for-luts-in-bph-a-double-blind-randomized-trial
#8
Chikka Moga Siddaiah Manohar, Mahadevappa Nagabhushana, Vilvapathy Senguttuvan Karthikeyan, Ramachandra Pudakalkatti Sanjay, Ananth Janardhan Kamath, Ramaiah Keshavamurthy
INTRODUCTION: Currently alpha1-adrenoceptor blockers (AB) are widely used as first-line therapy to improve lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). We compared the efficacy and safety profile of tamsulosin, alfuzosin and silodosin in LUTS due to BPH. MATERIAL AND METHODS: Consecutive consenting male patients (N = 269) undergoing medical management of BPH with AB from February 2012 to October 2015 were enrolled. Patients were randomized to a 0...
June 30, 2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28718166/can-long-term-luts-bph-pharmacological-treatment-alter-the-outcomes-of-surgical-intervention
#9
REVIEW
Fabrizio Presicce, Cosimo De Nunzio, Andrea Tubaro
PURPOSE OF REVIEW: We have reviewed the available evidence on the impact of long-term pharmacological treatment of lower urinary tract symptoms on the outcomes of benign prostatic hyperplasia surgery. EVIDENCE ACQUISITION: A systematic literature search from January 1990 to May 2017 was performed. Only references in the English language and peer-reviewed manuscripts were considered. RECENT FINDINGS: Over time, the ever-increasing use of long-term pharmaceutical treatments has considerably reduced the rate of BPH surgery in most countries...
September 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28717651/comparison-of-nonspherical-polyvinyl-alcohol-particles-and-microspheres-for-prostatic-arterial-embolization-in-patients-with-benign-prostatic-hyperplasia
#10
Jin Ho Hwang, Sang Woo Park, Il Soo Chang, Sung Il Jung, Hae Jeong Jeon, Yong Soo Lho, Hyeong Gon Kim, Sung Hyun Paick, Hyoung Keun Park
PURPOSE: To report early results following prostatic artery embolization (PAE) and compare outcomes between nonspherical polyvinyl alcohol (PVA) particles and microspheres to treat lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). METHODS: PAE was performed in nine patients (mean age: 78.1 years) with symptomatic BPH. Embolization was performed using nonspherical PVA particles (250-355 μm) in four patients and microspheres (300-500 μm) in five patients...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28717543/outcome-analysis-of-transurethral-resection-versus-potassium-titanyl-phosphate-photo-selective-vaporization-of-the-prostate-for-the-treatment-of-benign-prostatic-hyperplasia-a-randomized-controlled-trial-with-4-years-follow-up
#11
Bimalesh Purkait, Rahul Janak Sinha, Krishna Swamy A Srinivas, Ankur Bansal, Ashok Kumar Sokhal, Vishwajeet Singh
OBJECTIVE: Photovaporization of prostate (PVP) is a newer surgical modality of benign prostatic hyperplasia (BPH) which is gaining importance recently. There are a few randomized controlled trials that showed safety and efficacy of PVP in comparison with transurethral resection of prostate (TURP) with limited follow-up period (<2 years). Here, we are presenting a comparative study performed on potassium titanyl phosphate (KTP) PVP laser versus TURP for the treatment of BPH with long-term follow-up period...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28715215/manipulating-the-energetics-and-rates-of-electron-transfer-in-rhodobacter-capsulatus-reaction-centers-with-asymmetric-pigment-content
#12
Kaitlyn M Faries, Nicholas P Dylla, Deborah K Hanson, Dewey Holten, Philip D Laible, Christine Kirmaier
Seemingly redundant parallel pathways for electron transfer (ET), composed of identical sets of cofactors, are a cornerstone feature of photosynthetic reaction centers (RCs) involved in light-energy conversion. In native bacterial RCs, both A and B branches house one bacteriochlorophyll (BChl) and one bacteriopheophytin (BPh), but the A branch is used exclusively. Described herein are the results obtained for two Rhodobacter capsulatus RCs with an unnaturally high degree of cofactor asymmetry, two BPh on the RC's B side and two BChl on the A side...
July 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28711970/does-a-male-polycystic-ovarian-syndrome-equivalent-exist
#13
REVIEW
R Cannarella, R A Condorelli, L M Mongioì, S La Vignera, A E Calogero
The occurrence of a genetic background in the etiology of polycystic ovarian syndrome (PCOS) represents the rational basis to postulate the existence of a male PCOS equivalent. Hormonal and metabolic abnormalities have been described in male relatives of women with PCOS. These males also have a higher prevalence of early onset (<35 years) androgenetic alopecia (AGA). Hence, this feature has been proposed as a clinical sign of the male PCOS equivalent. Clinical evidence has shown that men with early onset AGA have hormonal and metabolic abnormalities...
July 15, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28709945/punicalagin-a-polyphenol-from-pomegranate-fruit-induces-growth-inhibition-and-apoptosis-in-human-pc-3-and-lncap-cells
#14
Oluwatosin Adaramoye, Bettina Erguen, Bianca Nitzsche, Michael Höpfner, Klaus Jung, Anja Rabien
Prostate cancer (PCa) is an international health problem and search for its effective treatment is in progress. Punicalagin (PN), polyphenol from pomegranate fruit, is known to exhibit potent anticancer activity in lung, breast and cervical cells. However, there is paucity of information on its effect in PCa. This study evaluated anti-proliferative effects of PN and its effects on extrinsic pathway of apoptosis in PCa cells, and angiogenesis in chicken chorioallantoic membrane (CAM). Antioxidant activities of PN were determined by 2,2-diphenyl-1-picryhydrazyl (DPPH) radical scavenging and inhibition of lipid peroxidation (LPO) methods...
July 11, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28708525/assessment-of-the-age-for-a-preventive-ultrasonographic-examination-of-the-prostate-in-the-dog
#15
G Mantziaras, S Alonge, M Faustini, G C Luvoni
The prostate commonly develops benign prostatic hyperplasia (BPH) in dogs over 5 years, while in aged dogs other pathological findings might be revealed by ultrasonographic exam. The aim of the present study was to estimate the most suitable age for a preventive ultrasonographic examination of the prostate in the dog. The prostate of 1003 intact male dogs of 64 different breeds, of different ages (1-18 years) and bodyweights (2-55 kg) was evaluated with ultrasound, irrespective of the reason for clinical examination...
June 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/28702148/comparative-analysis-of-resected-prostate-weight-in-diabetic-and-non-diabetic-benign-prostatic-hyperplasia-patients
#16
Emadoddin Moudi, Abazar Akbarzadeh-Pasha
BACKGROUND: Benign prostatic hyperplasia (BPH) is the most common benign tumor in men. The etiology of BPH is still unresolved and multiple systems are likely to be involved. The effects of diabetes on urinary system are a risk factor for BPH. We then assessed the effects of diabetes on the parameters related to BPH, especially weight and volume. METHODS: This study was conducted on patients with BPH who underwent surgery during 2010-2013. The patients' demographic and clinical data including age, height, weight, history of diabetes, abdominal sonography, prostate-specific antigen(PSA), fasting blood sugar (FBS), triglyceride, and cholesterol, resected sample weight, and pathological diagnosis were extracted...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28701765/the-cancer-associated-cell-migration-protein-tspan1-is-under-control-of-androgens-and-its-upregulation-increases-prostate-cancer-cell-migration
#17
Jennifer Munkley, Urszula L McClurg, Karen E Livermore, Ingrid Ehrmann, Bridget Knight, Paul Mccullagh, John Mcgrath, Malcolm Crundwell, Lorna W Harries, Hing Y Leung, Ian G Mills, Craig N Robson, Prabhakar Rajan, David J Elliott
Cell migration drives cell invasion and metastatic progression in prostate cancer and is a major cause of mortality and morbidity. However the mechanisms driving cell migration in prostate cancer patients are not fully understood. We previously identified the cancer-associated cell migration protein Tetraspanin 1 (TSPAN1) as a clinically relevant androgen regulated target in prostate cancer. Here we find that TSPAN1 is acutely induced by androgens, and is significantly upregulated in prostate cancer relative to both normal prostate tissue and benign prostate hyperplasia (BPH)...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28696287/genomic-architecture-of-biomass-heterosis-in-arabidopsis
#18
Mei Yang, Xuncheng Wang, Diqiu Ren, Hao Huang, Miqi Xu, Guangming He, Xing Wang Deng
Heterosis is most frequently manifested by the substantially increased vigorous growth of hybrids compared with their parents. Investigating genomic variations in natural populations is essential to understand the initial molecular mechanisms underlying heterosis in plants. Here, we characterized the genomic architecture associated with biomass heterosis in 200 Arabidopsis hybrids. The genome-wide heterozygosity of hybrids makes a limited contribution to biomass heterosis, and no locus shows an obvious overdominance effect in hybrids...
July 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28694823/the-persistence-of-silodosin-monotherapy-and-the-reasons-for-withdrawal-from-treatment-of-previously-untreated-japanese-patients-with-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-hyperplasia
#19
Yoshinori Tanaka, Yasushi Tanuma, Naoya Masumori
OBJECTIVES: The persistence of silodosin and the reasons for withdrawal from treatment of previously untreated Japanese patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) were evaluated in real-life clinical practice. METHODS: A total of 81 previously untreated Japanese patients diagnosed with LUTS/BPH were treated with silodosin monotherapy and prospectively followed for 4 years. The persistence rate was estimated using the Kaplan-Meier method...
2017: Advances in Urology
https://www.readbyqxmd.com/read/28694768/the-androgen-receptor-plays-different-roles-in-macrophage-induced-proliferation-in-prostate-stromal-cells-between-transitional-and-peripheral-zones-of-benign-prostatic-hypertrophy
#20
Dongliang Xu, Xingjie Wang, Chenyi Jiang, Yuan Ruan, Shujie Xia, Xiaohai Wang
Macrophages play a critical role in the process of excessive stromal proliferation of benign prostatic hyperplasia (BPH). In our previous study, we used a BPH mouse model to elucidate a potential mechanism whereby macrophage infiltration promotes stromal cell proliferation in the prostate via the androgen receptor (AR)/inflammatory cytokine CCL3-dependent pathway. In our present study, we used the co-culture system of human macrophages and various prostatic zone stromal cells to further demonstrate that infiltrating macrophages promote prostatic stromal cell proliferation through stromal AR-dependent pathways, and we show that the stroma of TZ and PZ respond to macrophages differently because of differences in stromal AR signaling; this could possibly be one of the key pathways for stromal expansion during BPH development and progression...
2017: EXCLI journal
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