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https://www.readbyqxmd.com/read/28430620/genetic-association-between-psa-158g-a-polymorphism-and-the-susceptibility-of-benign-prostatic-hyperplasia-a-meta-analysis
#1
REVIEW
Xin-Jun Su, Xian-Tao Zeng, Cheng Fang, Tong-Zu Liu, Xing-Huan Wang
Inconsistency between reported findings on the association of prostate specific antigen (PSA) gene -158G/A polymorphism with benign prostatic hyperplasia (BPH) susceptibility need a meta-analysis to obtain a more accurate conclusion. A systematic search was conducted in electronic databases for the collection of eligible studies on PSA -158G/A polymorphism and BPH susceptibility. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were then calculated. 7 case-control studies with 758 cases and 752 controls were included into the present meta-analysis...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28428671/correlation-of-subjective-symptoms-in-patients-with-benign-prostatic-hyperplasia-and-erectile-dysfunction
#2
Amel Kardasevic, Snjezana Milicevic
INTRODUCTION: Epidemiological studies suggest a link between the symptoms of lower urinary tract (LUTS) caused by benign prostatic hyperplasia (BPH) and erectile dysfunction (ED). Increasing expected period of life, justify the interest of establishing correlations LUTS / BPH and ED in order to find more efficient ways of treating these pathologies. GOAL: The objective was to evaluate the correlation of symptoms in LUTS/BPH with the degree of ED. PATIENTS AND METHODS: The study was conducted as a prospective study which involved males aged 40-60 yr with present symptoms of LUTS/BPH...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28422535/comparison-between-normal-saline-and-ringer-s-acetate-in-bipolar-transurethral-resection-of-the-prostate
#3
Ehab Ahmed, Jacob Ingvar, Claes R Nyman, Ulf Norming, Emma Andersson, Robert G Hahn, Tim Fagerström
OBJECTIVE: The standard surgical treatment for benign prostatic hypertrophy (BPH) is transurethral resection of the prostate (TURP). The aim of this study was to compare normal saline (NS) (0.9% sodium chloride) and Ringer's acetate (RA) as irrigation fluid with regard to visibility, resection feasibility, coagulation and bleeding in bipolar TURP. MATERIALS AND METHODS: Twenty patients (mean age 70 years) who were diagnosed with BPH were recruited to the study. The first three 3 liter bags of irrigation fluid contained either NS or RA and were administered in a randomized fashion...
April 19, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28420168/comparative-study-of-blood-based-biomarkers-%C3%AE-2-3-sialic-acid-psa-and-phi-for-high-risk-prostate-cancer-detection
#4
Montserrat Ferrer-Batallé, Esther Llop, Manel Ramírez, Rosa Núria Aleixandre, Marc Saez, Josep Comet, Rafael de Llorens, Rosa Peracaula
Prostate Specific Antigen (PSA) is the most commonly used serum marker for prostate cancer (PCa), although it is not specific and sensitive enough to allow the differential diagnosis of the more aggressive tumors. For that, new diagnostic methods are being developed, such as PCA-3, PSA isoforms that have resulted in the 4K score or the Prostate Health Index (PHI), and PSA glycoforms. In the present study, we have compared the PHI with our recently developed PSA glycoform assay, based on the determination of the α2,3-sialic acid percentage of serum PSA (% α2,3-SA), in a cohort of 79 patients, which include 50 PCa of different grades and 29 benign prostate hyperplasia (BPH) patients...
April 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28416373/inhibition-effects-of-chlorogenic-acid-on-benign-prostatic-hyperplasia-in-mice
#5
Ya Huang, Huaguo Chen, Xin Zhou, Xingdong Wu, Enming Hu, Zhengmeng Jiang
This study aimed to evaluate the inhibitory effects and explore mechanisms of chlorogenic acid against testosterone-induced benign prostatic hyperplasia (BPH) in mice. Benign prostatic hyperplasia model was induced in experimental groups by daily subcutaneous injections of testosterone propionate (7.5mg/kg/d) consecutively for 14 d. A total of 60 mice were randomly divided into six groups: (Group 1) normal control group, (Group 2) benign prostatic hyperplasia model control group, (Group 3) benign prostatic hyperplasia mice treated with finasteride at a dose of 1mg/kg, (Group 4) benign prostatic hyperplasia mice treated with chlorogenic acid at dose levels of 0...
April 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28414251/impact-of-metabolic-status-on-the-association-of-serum-vitamin-d-with-hypogonadism-and-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia
#6
Sun Gu Park, Jeong Kyun Yeo, Dae Yeon Cho, Min Gu Park
OBJECTIVE: The objective of this study is to investigate the impact of metabolic status on associations of serum vitamin D with hypogonadism and lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH). PATIENTS AND METHODS: A total of 612 men underwent physical examination, biochemical/hormonal blood testing, and transrectal prostate ultrasound. Moreover, the subjects filled out standard questionnaires for identification and grading of LUTS and hypogonadism symptoms...
April 17, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28412472/preparation-and-characterization-of-dutasteride-loaded-nanostructured-lipid-carriers-coated-with-stearic-acid-chitosan-oligomer-for-topical-delivery
#7
Norhayati Mohamed Noor, Khalid Sheikh, Satyanarayana Somavarapu, Kevin Mg Taylor
Dutasteride, used for treating benign prostate hyperplasia (BPH), promotes hair growth. To enhance delivery to the hair follicles and reduce systemic effects, in this study dutasteride has been formulated for topical application, in a nanostructured lipid carrier (NLC) coated with chitosan oligomer-stearic acid (CSO-SA). CSO-SA has been successfully synthesized, as confirmed using (1)H NMR and FTIR. Formulation of dutasteride-loaded nanostructured lipid carriers (DST-NLCs) was optimised using 2(3) full factorial design...
April 12, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28412354/role-of-gpr30-in-estrogen-induced-prostate-epithelial-apoptosis-and-benign-prostatic-hyperplasia
#8
Deng-Liang Yang, Jia-Wen Xu, Jianguo Zhu, Yi-Lin Zhang, Jian-Bang Xu, Qing Sun, Xiao-Nian Cao, Wu-Lin Zuo, Ruo-Shui Xu, Jiehong Huang, Fu-Neng Jiang, Yang-Jia Zhuo, Bai-Quan Xiao, Yun-Zhong Liu, Dongbo Yuan, Zhaolin Sun, Hui-Chan He, Zhao-Rong Lun, Wei-De Zhong, Wen-Liang Zhou
Several studies have implicated estrogen and the estrogen receptor (ER) in the pathogenesis of benign prostatic hyperplasia (BPH); however, the mechanism underlying this effect remains elusive. In the present study, we demonstrated that estrogen (17β-estradiol, or E2)-induced activation of the G protein-coupled receptor 30 (GPR30) triggered Ca(2+) release from the endoplasmic reticulum, increased the mitochondrial Ca(2+) concentration, and thus induced prostate epithelial cell (PEC) apoptosis. Both E2 and the GPR30-specific agonist G1 induced a transient intracellular Ca(2+) release in PECs via the phospholipase C (PLC)-inositol 1, 4, 5-triphosphate (IP3) pathway, and this was abolished by treatment with the GPR30 antagonist G15...
April 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28406126/correlation-between-international-prostate-symptom-score-and-uroflowmetry-in-patients-with-benign-prostatic-hyperplasia
#9
C K Oranusi, A E Nwofor, O Mbonu
OBJECTIVE: To determine the correlation between severity of symptoms using the International Prostate Symptom Score (IPSS) and uroflowmetry in patients with lower urinary tract symptoms-benign prostatic hyperplasia (LUTS-BPH). PATIENTS AND METHODS: We prospectively collected data from 51 consecutive men, who presented with LUTS-BPH at the Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria, from January 2012 through December, 2014. Symptom severity was assessed using the self-administered IPSS questionnaire...
April 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28403597/a-retrospective-comparison-between-transrectal-and-transperineal-prostate-biopsy-in-the-detection-of-prostate-cancer
#10
Carmelo Agostino Di Franco, Hussein Jallous, Daniele Porru, Giovanni Luca Giliberto, Tiziano Cebrelli, Carmine Tinelli, Bruno Rovereto
BACKGROUND: The aim of this study was to analyze the differences between TRUSguided transrectal prostate biopsy (TR) and transperineal prostate biopsy (TP) in the diagnosis of prostate cancer. The two biopsy methods were evaluated in terms of diagnostic sensitivity and of early and late complications. METHODS: This retrospective study was realized through the review of clinical records of 219 men that received a prostate biopsy between 2004 and 2014. The biopsy was performed because of elevated prostate-specific antigen (PSA), abnormal digital rectal examination findings (DRE), abnormal transrectal ultrasound (TRUS) findings and symptoms due to prostate diseases...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28403591/comparison-of-the-clinical-parameters-of-benign-prostate-hyperplasia-in-diabetic-and-non-diabetic-patients
#11
Levent Ozcan, Huseyin Besiroglu, Murat Dursun, Emre Can Polat, Alper Otunctemur, Emin Ozbek
OBJECTIVE: We evaluated the correlation between benign prostate hyperplasia (BPH) measures and diabetes mellitus in men with benign prostate hyperplasia in a prospective study. MATERIALS AND METHODS: Between 2008-2012, 100 diabetic and 200 non diabetic patients undergoing surgery due to benign prostate hyperplasia were enrolled in the study. The parameters evaluated for each patients included prostate volume, fasting blood glucose, HbA1c, total testosterone, total prostatic specific antigen (T-PSA), triglicerides, total cholesterol and body mass index (BMI)...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28403588/daidzein-plus-isolase-associated-with-zinc-improves-clinical-symptoms-and-quality-of-life-in-patients-with-luts-due-to-benign-prostatic-hyperplasia-results-from-a-phase-i-ii-study
#12
Daniele Tiscione, Luca Gallelli, Irene Tamanini, Lorenzo Giuseppe Luciani, Paolo Verze, Alessandro Palmieri, Vincenzo Mirone, Riccardo Bartoletti, Gianni Malossini, Tommaso Cai
OBJECTIVE: In the last years there is a growing interest in nutraceutical substances that seems able to improve clinical symptoms in patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). In this paper, we evaluated both efficacy and safety of a combination of daidzein with isolase and zinc in patients with LUTS due to BPH. MATERIALS AND METHODS: In a phase I-II study clinical trial we enrolled patients with clinical and instrumental diagnosis of LUTS associated to BPH that received a six-month treatment with a combination of daidzein with isolase and zinc (1 tablet/day)...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28401865/the-effect-of-mitral-valve-surgery-on-ventricular-arrhythmia-in-patients-with-bileaflet-mitral-valve-prolapse
#13
Niyada Naksuk, Faisal F Syed, Chayakrit Krittanawong, Mark J Anderson, Elisa Ebrille, Christopher V DeSimone, Vaibhav R Vaidya, Shiva P Ponamgi, Rakesh M Suri, Michael J Ackerman, Vuyisile T Nkomo, Samuel J Asirvatham, Peter A Noseworthy
BACKGROUND: Bileaflet mitral valve prolapse (biMVP) is associated with frequent ventricular ectopy (VE) and malignant ventricular arrhythmia. We examined the effect of mitral valve (MV) surgery on VE burden in biMVP patients. METHODS: We included 32 consecutive patients undergoing MV surgery for mitral regurgitation secondary to biMVP between 1993 and 2012 at Mayo Clinic who had available pre- and post-operative Holter monitoring data. Characteristics of patients with a significant reduction in postoperative VE (group A, defined as >10% reduction in VE burden compared to baseline) were compared with the rest of study patients (group B)...
November 2016: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/28398479/clinical-significance-of-mirna-host-gene-promoter-methylation-in-prostate-cancer
#14
Kristina Daniunaite, Monika Dubikaityte, Povilas Gibas, Arnas Bakavicius, Juozas Rimantas Lazutka, Albertas Ulys, Feliksas Jankevicius, Sonata Jarmalaite
Only a part of prostate cancer (PCa) patients has aggressive malignancy requiring adjuvant treatment after radical prostatectomy (RP). Biomarkers capable to predict biochemical PCa recurrence (BCR) after RP would significantly improve preoperative risk stratification and treatment decisions. MicroRNA (miRNA) deregulation has recently emerged as an important phenomenon in tumor development and progression, however, the mechanisms remain largely unstudied. In the present study, based on microarray profiling of DNA methylation in 9 pairs of PCa and noncancerous prostate tissues (NPT), host genes of miR-155-5p, miR-152-3p, miR-137, miR-31-5p, and miR-642a, -b were analyzed for promoter methylation in 129 PCa, 35 NPT, and 17 benign prostatic hyperplasia samples (BPH) and compared to the expression of mature miRNAs and their selected targets (DNMT1, KDM1A, and KDM5B)...
April 7, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28394524/-x-ray-guided-endovascular-surgery-in-patients-with-benign-prostatic-hyperplasia-and-prostate-cancer
#15
A I Neimark, M A Tachalov, B A Neimark, D V Torbik, D D Arzamastsev
AIM: To evaluate the efficacy and safety of superselective embolization and chemoembolization of the prostatic artery as an independent method of treating prostate cancer and BPH. MATERIALS AND METHODS: From 2004 to 2015, 116 patients with BPH (mean age 73.2+/-5.2 years) underwent prostatic artery embolization. Mean prostate volume ranged from 55 to 296 cc3. From 2011 to 2015, 37 patients with prostate cancer (mean age 72.3+/-2.06 years) were treated with X-ray-guided endovascular chemoembolization...
April 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28394492/treatment-patterns-and-patient-reported-outcomes-in-benign-prostatic-hyperplasia-patients-with-overactive-bladder-symptoms
#16
Yong Hyun Park, Tae Hyo Kim, Seung Wook Lee, Byung Ha Chung, Jin Seon Cho, Ji Youl Lee
OBJECTIVES: We aimed to examine the treatment patterns, and patient-reported outcomes (PROs) in benign prostatic hyperplasia (BPH) patients with overactive bladder (OAB) symptoms. METHODS: Seven hundred and forty seven patients were included in this prospective observational study. The primary endpoint was to describe the medical treatment patterns for BPH patients with OAB symptoms. The secondary endpoint was to determine the PROs of these patients. Clinical outcome was assessed using International prostate symptom score (IPSS), and PROs were measured using BPH-Related QoL Questionnaire Korea 1 (BPH QoL K1) and Euroqol-5 Dimension (EQ-5D)...
May 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28393495/the-bph6-study-raises-the-bar-on-how-we-should-conduct-bph-surgical-trials
#17
EDITORIAL
Henry H Woo
No abstract text is available yet for this article.
May 2017: BJU International
https://www.readbyqxmd.com/read/28391389/combination-therapy-with-omega-3-fatty-acids-plus-tamsulocin-and-finasteride-in-the-treatment-of-men-with-lower-urinary-tract-symptoms-luts-and-benign-prostatic-hyperplasia-bph
#18
Alireza Ghadian, Mehran Rezaei
PURPOSE: Inflammation and Cyclooxygenase-2 (COX-2) as a part of it are common in BPH specimens and may play a role in the pathogenesis of the disease through cytokines that promote cell growth or lead to smooth muscle contraction. The aim of this study is to analyze whether combination therapy with omega-3 fatty acids, which have anti-inflammatory and COX-2 inhibitory effects, and tamsulocin plus finasteride offers an advantage compared to tamsulocin plus finasteride therapy in patients with BPH...
April 8, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28386189/the-effect-of-leonuri-herba-alkaloids-on-senile-bph-male-and-female-hormone-induced-model-rats
#19
Mingsan Miao, Tan Wang, Jing Liu, Yan Li, Zhenna Fu, Shuo Tian
Objective: To investigate the pharmacological effects of Leonuri Herba alkaloids (LHA) on prostate hyperplasia in older rats and the effect mechanism. Methods: Remove bilateral testes from BPH model rats, and conduct subcutaneous injection of testosterone and estradiol. At the same time, feed corresponding drugs to the rats by gastric perfusion for 30d. In the first 27d, conduct bladder fistula surgery. Three days after feeding, carry out the detection of the urine flow dynamics. Eyeball blood taking, determination of serum E2 levels, and quickly remove the prostate, thymus gland, spleen, kidney, lung, and bladder...
March 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28383825/the-fibroblast-surface-markers-fap-anti-fibroblast-and-fsp-are-expressed-by-cells-of-epithelial-origin-and-may-be-altered-during-epithelial-to-mesenchymal-transition
#20
Zuzana Kahounová, Daniela Kurfürstová, Jan Bouchal, Gvantsa Kharaishvili, Jiří Navrátil, Ján Remšík, Šárka Šimečková, Vladimír Študent, Alois Kozubík, Karel Souček
The identification of fibroblasts and cancer-associated fibroblasts from human cancer tissue using surface markers is difficult, especially because the markers used currently are usually not expressed solely by fibroblasts, and the identification of fibroblast-specific surface molecules is still under investigation. It was aimed to compare three commercially available antibodies in the detection of different surface epitopes of fibroblasts (anti-fibroblast, fibroblast activation protein α, and fibroblast surface protein)...
April 6, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
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