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https://www.readbyqxmd.com/read/27909989/orexin-and-central-modulation-of-cardiovascular-and-respiratory-function
#1
Pascal Carrive, Tomoyuki Kuwaki
Orexin makes an important contribution to the regulation of cardiorespiratory function. When injected centrally under anesthesia, orexin increases blood pressure, heart rate, sympathetic nerve activity, and the amplitude and frequency of respiration. This is consistent with the location of orexin neurons in the hypothalamus and the distribution of orexin terminals at all levels of the central autonomic and respiratory network. These cardiorespiratory responses are components of arousal and are necessary to allow the expression of motivated behaviors...
December 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27906778/the-role-of-prostatic-inflammation-in-the-development-and-progression-of-benign-and-malignant-diseases
#2
Giorgio Gandaglia, Emanuele Zaffuto, Nicola Fossati, Vito Cucchiara, Vincenzo Mirone, Francesco Montorsi, Alberto Briganti
PURPOSE OF REVIEW: To evaluate the role of prostatic inflammation in the development and progression of benign and malignant prostatic diseases. RECENT FINDINGS: Preclinical studies demonstrate that the activation of a chronic inflammatory prostatic response plays an important role in the pathogenesis and progression of benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Approximately 40-70% of patients with BPH-related lower urinary tract symptoms harbour chronic inflammation at pathologic evaluation...
November 30, 2016: Current Opinion in Urology
https://www.readbyqxmd.com/read/27905698/bladder-neck-contracture-after-surgery-for-benign-prostatic-obstruction-a-literature-review
#3
Luca Cindolo, Michele Marchioni, Esteban Emiliani, Piergustavo De Francesco, Giulia Primiceri, Pietro Castellan, Luigi Schips
INTRODUCTION: Over the last decades, numerous surgical procedures have been proposed to treat Lower Urinary Tract Symptoms (LUTS) secondary to Benign Prostatic Hyperplasia (BPH). However, all are characterized by a certain rate of treatment failure due to Bladder Neck Contracture (BNC). Treatment of secondary BNC appears to be challenging. The main purpose of this review is to evaluate current published knowledge on this topic. EVIDENCE ACQUISITION: The MEDLINE/Pubmed database was searched for all original articles published between 2000 and 2016 analysing the incidence, prevalence and management of BNC as a post-operative complication following surgical treatment of LUTS/BPH...
December 1, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27904652/urolift-a-new-minimally-invasive-treatment-for-benign-prostatic-hyperplasia
#4
REVIEW
Patrick Jones, Bhavan P Rai, Omar Aboumarzouk, Bhaskar K Somani
'UroLift' has emerged as a new minimally-invasive nonablative surgical technique for benign prostatic hyperplasia (BPH). We discuss the procedure, cost, evidence, advantages and disadvantages of this procedure. It is a novel technology suitable for a selected group of patients that allows for a bespoke treatment for men with BPH.
December 2016: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/27903952/how-readable-is-bph-treatment-information-on-the-internet-assessing-barriers-to-literacy-in-prostate-health
#5
Kevin Koo, Ronald L Yap
Information about benign prostatic hyperplasia (BPH) has become increasingly accessible on the Internet. Though the ability to find such material is encouraging, its readability and impact on informing patient decision making are not known. To evaluate the readability of Internet-based information about BPH in the context of website ownership and Health on the Net certification, three search engines were queried daily for 1 month with BPH-related keywords. Website ownership data and Health on the Net certification status were verified...
November 29, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27901104/development-and-evaluation-of-near-isogenic-lines-for-brown-planthopper-resistance-in-rice-cv-9311
#6
Cong Xiao, Jie Hu, Yi-Ting Ao, Ming-Xing Cheng, Guan-Jun Gao, Qing-Lu Zhang, Guang-Cun He, Yu-Qing He
Brown planthopper (BPH) is the most destructive pest of rice in Asia. To date 29 BPH resistance genes have been identified, but only a few genes are being used in breeding due to inefficient markers for marker-assisted selection (MAS) and little knowledge of the real effects of the genes. In this study we individually transferred 13 genes or QTLs (Bph14, QBph3, QBph4, Bph17, Bph15, Bph20, Bph24, Bph6, Bph3, Bph9, Bph10, Bph18 and Bph21) into cultivar 9311 by marker assisted backcross breeding (MABB). Through positive and negative selection we narrowed the segments from donors containing Bph14, Bph15, Bph6 and Bph9 to 100-400 kb...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900218/a-prospective-randomised-controlled-study-comparing-bipolar-plasma-vaporisation-of-the-prostate-to-monopolar-transurethral-resection-of-the-prostate
#7
Ahmed M Elsakka, Hssan H Eltatawy, Khaled H Almekaty, Ahmed R Ramadan, Tarik A Gameel, Yasser Farahat
OBJECTIVES: To compare the safety and efficacy of bipolar transurethral plasma vaporisation (B-TUVP) as an alternative to the 'gold standard' monopolar transurethral resection of the prostate (M-TURP) for the treatment of benign prostatic hyperplasia (BPH) in a prospective randomised controlled study. PATIENTS AND METHODS: In all, 82 patients indicated for prostatectomy were assigned to two groups, group I (40 patients) underwent B-TUVP and group II (42 patients) underwent M-TURP...
December 2016: Arab Journal of Urology
https://www.readbyqxmd.com/read/27896711/using-eq-5d-3l-and-oab-5d-to-assess-changes-in-the-health-related-quality-of-life-of-men-with-lower-urinary-tract-symptoms-associated-with-benign-prostatic-hyperplasia
#8
Zalmai Hakimi, Mike Herdman, Marco Pavesi, Nancy Devlin, Jameel Nazir, Chris Hoyle, Isaac A O Odeyemi
OBJECTIVES: To assess changes in the health status of men with lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) using the EQ-5D-3L and OAB-5D instruments and to evaluate the sensitivity of the instruments. METHODS: Data were available from a large randomised phase III trial of men with moderate-to-severe storage and voiding LUTS/BPH (NEPTUNE). Men received a fixed-dose combination of solifenacin 6 mg plus oral controlled absorption system (OCAS™) formulation of tamsulosin (TOCAS, 0...
November 28, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27894613/comparative-study-between-thulium-laser-tm-yag-150w-and-greenlight-laser-lbo-nd-yag-120w-for-the-treatment-of-benign-prostatic-hyperpplasia-short-term-efficacy-and-security
#9
J L Palmero-Martí, J Panach-Navarrete, L Valls-González, A Ganau-Ituren, J Miralles-Aguado, A Benedicto-Redón
OBJECTIVE: To compare the results of efficacy and safety of Thulium laser 150W against Greenlight laser 120W in the treatment of short term benign prostatic hyperplasia (12 months after surgery). MATERIAL AND METHODS: This is a retrospective observational study where men who underwent the surgical technique of prostate vaporization over a period of four years in our center are included. The homogeneity of the sample was checked, and postoperative complications (acute urinary retention, reentry, need for transfusion), failures per year of surgery (reoperation, peak flow <15ml/sec, no improvement in comparing the I-PSS), and decreased PSA were compared a year after surgery...
November 25, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27893755/quantification-of-arachidonic-acid-and-its-metabolites-in-rat-tissues-by-uhplc-ms-ms-application-for-the-identification-of-potential-biomarkers-of-benign-prostatic-hyperplasia
#10
Qiaoxia Bian, Weihui Wang, Nannan Wang, Yan Peng, Wen Ma, Ronghua Dai
To evaluate the potential relationship between benign prostatic hyperplasia (BPH) and the arachidonic acid (AA) metabolome, a UHPLC-MS/MS method has been developed and validated for simultaneous determination of AA and its cyclooxygenase(COX) and lipoxygenase(LOX) pathway metabolites (15-HETE, 12-HETE, TXA2, 5-HETE, AA, PGI2, PGF2α, 8-HETE, PGD2, PGE2 and LTB4) in rat tissues. The analytes were extracted from tissue samples with a protein precipitation procedure and then separated on a Shim-pack XR-ODSC18 column with 0...
2016: PloS One
https://www.readbyqxmd.com/read/27891339/bacteriological-profile-of-isolates-from-urine-samples-in-patients-of-benign-prostatic-hyperplasia-and-or-prostatitis-showing-lower-urinary-tract-symptoms
#11
Prem Prakash Mishra, Ved Prakash, Kashmir Singh, H Mog, Sumit Agarwal
INTRODUCTION: The incidence of Benign Prostatic Hyperplasia (BPH) or Prostatitis is increasing considerably worldwide. The Lower Urinary Tract Symptoms (LUTS) due to bacterial aetiology are one of the common factors for the complications among the patients. AIM: To determine the bacterial agents and their antibiotic sensitivity pattern from the urine samples of patients of BPH or Prostatitis showing symptoms of LUTS. MATERIALS AND METHODS: The cross-sectional study was carried out in the Department of Microbiology of Rohilkhand Medical College and Hospital of Northern India from June 2014 to May 2015...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889014/-the-role-of-alpha-blockers-in-the-treatment-of-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia-are-all-the-same-silodosin-in-real-life
#12
A Alcántara Montero
The lower urinary tract symptoms (LUTS) are very common in men, particularly in people over 65 years. Benign prostatic hyperplasia (BPH) is the pathology most associated with LUTS in males, and is a common cause of impaired quality of life. Alpha blockers monotherapy represent the treatment of choice in patients with moderate-severe LUTS secondary to BPH. Silodosin is currently the most α1A uroselective alpha blocker, uroselectivity which has been confirmed in several studies both in vitro and in vivo. In this paper the main benefits of silodosin are analyzed in both phase III clinical trials (standard approach) as in "real life" (analyzing the study SiRE [Silodosin in Real-life Evaluation], phase IV study), to validate the test data recording and confirm the positive benefit-risk profile of silodosin in a context that can reflect more closely the clinical practice...
July 2016: Semergen
https://www.readbyqxmd.com/read/27883117/combination-therapies-for-improved-management-of-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia
#13
C De Nunzio, F Presicce, A Tubaro
Several urological and non-urological conditions can contribute to the onset of lower urinary tract symptoms (LUTS), including benign prostatic hyperplasia (BPH), which is one of the main underlying causes in male patients. Six pharmacological classes (alpha-adrenoceptor blockers [ABs], 5alpha-reductase inhibitors [5ARIs], phytotherapeutics, antimuscarinics [AMs], beta3-adrenoceptor agonists and phosphodiesterase type 5 inhibitors [PDE5Is]) are available, alone or in combination, for the treatment of male LUTS...
September 2016: Drugs of Today
https://www.readbyqxmd.com/read/27882567/autoantibodies-directed-against-the-endothelin-a-receptor-in-patients-with-benign-prostatic-hyperplasia
#14
Gerd Wallukat, Burkhard Jandrig, Rudolf Kunze, Johann J Wendler, Johannes Müller, Martin Schostak, Ingolf Schimke
BACKGROUND: Over-stimulation of G-protein coupled receptors (GPCRs) such as α1-adrenergic, muscarinic, endothelin, and AT1 receptors is considered to drive benign prostatic hyperplasia (BHP) which is often associated with lower urinary tract syndrome (LUTS). However, in addition to physiologic GPCR ligands, there is a new class of autoantibodies called functional autoantibodies that target the same GPCRs (GPCR-AABs) for over-stimulation, thus, presenting pathogenic potency. We hypothesize that patients with BPH/LUTS could carry GPCR-AABs representing potential targets for treatment...
November 24, 2016: Prostate
https://www.readbyqxmd.com/read/27880726/chrysophanic-acid-reduces-testosterone-induced-benign-prostatic-hyperplasia-in-rats-by-suppressing-5%C3%AE-reductase-and-extracellular-signal-regulated-kinase
#15
Dong-Hyun Youn, Jinbong Park, Hye-Lin Kim, Yunu Jung, JongWook Kang, Mi-Young Jeong, Gautam Sethi, Kwang Seok Ahn, Jae-Young Um
Benign prostatic hyperplasia (BPH) is one of the most common chronic diseases in male population, of which incidence increases gradually with age. In this study, we investigated the effect of chrysophanic acid (CA) on BPH. BPH was induced by a 4-week injection of testosterone propionate (TP). Four weeks of further injection with vehicle, TP, TP + CA, TP + finasteride was carried on. In the CA treatment group, the prostate weight was reduced and the TP-induced histological changes were restored as the normal control group...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27879967/the-influence-of-luts-medical-treatment-on-bph-surgery-do-we-operate-too-late
#16
Fabrizio Presicce, Cosimo DE Nunzio, Mauro Gacci, Roman Sosnowsky, Riccardo Lombardo, Francesco Porpiglia, Andrea Tubaro
BACKGROUND: To systematically collect the available evidence on the influence of Lower Urinary Tract Symptoms (LUTS) medical treatment on BPH surgery. EVIDENCE ACQUISITION: A systematic literature search January 1990 until June 2016 was performed by combining the following MESH terms: Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia, male, medical treatment surgical treatment, deferred/postponed treatment/intervention, early intervention/treatment. Each article title and abstract was reviewed for relevance and appropriateness with regards to the topic of this review...
November 23, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27879637/temperature-triggered-switchable-helix-helix-inversion-of-poly-phenylacetylene-bearing-l-valine-ethyl-ester-pendants-and-its-chiral-recognition-ability
#17
Yanli Zhou, Chunhong Zhang, Yuan Qiu, Lijia Liu, Taotao Yang, Hongxing Dong, Toshifumi Satoh, Yoshio Okamoto
A phenylacetylene containing the l-valine ethyl ester pendant (PAA-Val) was synthesized and polymerized by an organorhodium catalyst (Rh(nbd)BPh₄) to produce the corresponding one-handed helical cis-poly(phenylacetylene) (PPAA-Val). PPAA-Val showed a unique temperature-triggered switchable helix-sense in chloroform, while it was not observed in highly polar solvents, such as N,N'-dimethylformamide (DMF). By heating the solution of PPAA-Val in chloroform, the sign of the CD absorption became reversed, but recovered after cooling the solution to room temperature...
November 21, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27878112/withania-coagulans-extract-induces-cell-apoptosis-and-inhibits-cox-2-expression-in-a-rat-model-of-benign-prostatic-hyperplasia
#18
Maryam Sarbishegi, Ozra Khajavi, Mohammad Reza Arab
BACKGROUND: Phytotherapy is a popular treatment option in cases of benign prostatic hyperplasia (BPH), with many different herbal products being used for the treatment of this condition. Withania coagulans (WC) is an herbal medicine that has shown anti-tumoral, anti-inflammatory, and antioxidant effects. OBJECTIVES: This study examined the effect of Withania coagulans extract (WCE) on prostatic cell apoptosis and cyclooxygenase-2 (COX-2) expression in cases of benign prostatic hyperplasia (BPH) in rats...
September 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27876888/bph32-a-novel-gene-encoding-an-unknown-scr-domain-containing-protein-confers-resistance-against-the-brown-planthopper-in-rice
#19
Juansheng Ren, Fangyuan Gao, Xianting Wu, Xianjun Lu, Lihua Zeng, Jianqun Lv, Xiangwen Su, Hong Luo, Guangjun Ren
An urgent need exists to identify more brown planthopper (Nilaparvata lugens Stål, BPH) resistance genes, which will allow the development of rice varieties with resistance to BPH to counteract the increased incidence of this pest species. Here, using bioinformatics and DNA sequencing approaches, we identified a novel BPH resistance gene, LOC_Os06g03240 (MSU LOCUS ID), from the rice variety Ptb33 in the interval between the markers RM19291 and RM8072 on the short arm of chromosome 6, where a gene for resistance to BPH was mapped by Jirapong Jairin et al...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876748/driving-pest-insect-populations-agricultural-chemicals-lead-to-an-adaptive-syndrome-in-nilaparvata-lugens-st%C3%A3-l-hemiptera-delphacidae
#20
Lin-Lin You, You Wu, Bing Xu, Jun Ding, Lin-Quan Ge, Guo-Qin Yang, Qi-Sheng Song, David Stanley, Jin-Cai Wu
The brown planthopper (BPH) is a devastating pest of rice throughout Asia. In this paper we document the BPH biogeographic range expansion in China over the 20-year period, 1992 to 2012. We posed the hypothesis that the range expansion is due to a syndrome of adaptations to the continuous presence of agricultural chemicals (insecticides and a fungicide) over the last 40 years. With respect to biogeography, BPH ranges have expanded by 13% from 1992 to 1997 and by another 3% from 1997 to 2012. In our view, such expansions may follow primarily from the enhancing effects of JGM, among other agricultural chemicals, and from global warming...
November 23, 2016: Scientific Reports
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