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https://www.readbyqxmd.com/read/29786867/growth-hormone-releasing-hormone-antagonists-reduce-prostatic-enlargement-and-inflammation-in-carrageenan-induced-chronic-prostatitis
#1
Petra Popovics, Renzhi Cai, Wei Sha, Ferenc G Rick, Andrew V Schally
BACKGROUND: Inflammation plays a key role in the etiology of benign prostatic hyperplasia (BPH) through multiple pathways involving the stimulation of proliferation by cytokines and growth factors as well as the induction of the focal occurrence of epithelial-to-mesenchymal transition (EMT). We have previously reported that GHRH acts as a prostatic growth factor in experimental BPH and in autoimmune prostatitis models and its blockade with GHRH antagonists offer therapeutic approaches for these conditions...
May 21, 2018: Prostate
https://www.readbyqxmd.com/read/29775639/surgical-management-of-lower-urinary-tract-symptoms-attributed-to-benign-prostatic-hyperplasia-aua-guideline
#2
Harris E Foster, Michael J Barry, Philipp Dahm, Manhar C Gandhi, Steven A Kaplan, Tobias S Kohler, Lori B Lerner, Deborah J Lightner, J Kellogg Parsons, Claus G Roehrborn, Charles Welliver, Timothy J Wilt, Kevin T McVary
Purpose; Male lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) is common in men and can have negative effects on quality of life (QOL). It is the hope that this Guideline becomes a reference on the effective evidence-based surgical management of LUTS/BPH. MATERIALS/METHODS: The evidence team searched Ovid MEDLINE, the Cochrane Library, and the Agency for Healthcare Research and Quality (AHRQ) database to identify studies indexed between January 2007 and September 2017...
May 15, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29774816/holmium-laser-enucleation-of-the-prostate
#3
Marcelino E Rivera, James E Lingeman, Amy E Krambeck
INTRODUCTION: Holmium laser enucleation of the prostate (HoLEP) offers superior voiding outcomes to traditional transurethral resection and less morbidity than open simple prostatectomy. Likewise, HoLEP has been determined to result in excellent outcomes regardless of gland size. We present a step-by-step surgical approach to HoLEP describing both the traditional enucleation technique and a modified "top-down" surgical technique. MATERIALS AND METHODS: In this video, two techniques are presented that were performed by two (A...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29770312/state-of-the-art-of-prostatic-arterial-embolization-for-benign-prostatic-hyperplasia
#4
REVIEW
Mario Petrillo, Filippo Pesapane, Enrico Maria Fumarola, Ilaria Emili, Marzia Acquasanta, Francesca Patella, Salvatore Alessio Angileri, Umberto G Rossi, Igor Piacentini, Antonio Maria Granata, Anna Maria Ierardi, Gianpaolo Carrafiello
Prostatectomy via open surgery or transurethral resection of the prostate (TURP) is the standard treatment for benign prostatic hyperplasia (BPH). Several patients present contraindication for standard approach, individuals older than 60 years with urinary tract infection, strictures, post-operative pain, incontinence or urinary retention, sexual dysfunction, and blood loss are not good candidates for surgery. Prostatic artery embolization (PAE) is emerging as a viable method for patients unsuitable for surgery...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29767479/nocturia-is-more-bothersome-than-daytime-luts-results-from-an-observational-real-life-practice-database-including-8659-european-and-american-luts-patients
#5
Karel Everaert, Peter Anderson, Robert Wood, Fredrik L Andersson, Tove Holm-Larsen
PURPOSE: Lower urinary tract symptoms (LUTS) encompass several diagnoses, including overactive bladder (OAB) and benign prostatic hyperplasia (BPH). Nocturia is a standalone symptom, but also included in OAB and BPH. Current discussion addresses whether the overlap of the diagnoses is too broad, leading to misdiagnosis. This study explored the differences in level, causes and consequences for patients with a diagnosis of daytime LUTS compared with a diagnosis of nocturia, and discussed whether people are being treated for the symptoms that truly bother them the most...
May 16, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29760869/metabolic-alterations-in-urine-extracellular-vesicles-are-associated-to-prostate-cancer-pathogenesis-and-progression
#6
Marc Clos-Garcia, Ana Loizaga-Iriarte, Patricia Zuñiga-Garcia, Pilar Sánchez-Mosquera, Ana Rosa Cortazar, Esperanza González, Verónica Torrano, Cristina Alonso, Miriam Pérez-Cormenzana, Aitziber Ugalde-Olano, Isabel Lacasa-Viscasillas, Azucena Castro, Felix Royo, Miguel Unda, Arkaitz Carracedo, Juan M Falcón-Pérez
Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation and characterisation of urinary EVs could increase the efficiency of biomarker discovery. We have previously identified proteins and RNAs with differential abundance in urinary EVs from prostate cancer (PCa) patients compared to benign prostate hyperplasia (BPH). Here, we focused on the analysis of the metabolites contained in urinary EVs collected from patients with PCa and BPH. Targeted metabolomics analysis of EVs was performed by ultra-high-performance liquid chromatography-mass spectrometry...
2018: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/29756415/the-expression-of-androgen-receptor-and-its-variants-in-human-prostate-cancer-tissue-according-to-disease-status-and-its-prognostic-significance
#7
Sung Woo Park, Jung Hee Kim, Hyun Jung Lee, Dong Hoon Shin, Sang Don Lee, Sik Yoon
PURPOSE: To evaluate changes in the expression of androgen receptor (AR) and its variants (ARVs) in human prostate cancer (PCa) tissues according to disease status, and its prognostic significance following radical prostatectomy (RP). MATERIALS AND METHODS: A total of 282 PCa cases were evaluated, which included 252 localized PCa, 8 metastatic castration resistant prostate cancer (CRPC), and 22 benign prostatic hyperplasia (BPH) cases. Samples were collected from patients who underwent RP or transurethral resection and were stored in ethically approved tissue banks...
April 16, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29749520/silencing-of-urg11-expression-inhibits-the-proliferation-and-epithelial%C3%A2-mesenchymal-transition-in-benign-prostatic-hyperplasia-cells-via-the-rhoa-rock1-pathway
#8
Guanying Zhang, Feng Zhu, Guangye Han, Zeyu Li, Quanfeng Yu, Zhenhui Li, Jianchang Li
Upregulated gene 11 (URG11) represents a gene upregulated by hepatitis B virus X protein and is involved in the biological processes of multifarious tumors. The present study aimed to investigate the protective effects and regulatory mechanisms of URG11 in benign prostatic hyperplasia (BPH). URG11, Ras homolog family member A (RhoA) and Rho‑associated protein kinase 1 (ROCK1) expression was detected in patients with BPH using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). Furthermore, URG11 expression was silenced using URG11‑targeting small interfering RNAs...
May 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29749458/%C3%AE-klotho-inhibits-androgen-androgen-receptor%C3%A2-associated-epithelial%C3%A2-mesenchymal-transition-in-prostate-cancer-through-inactivation-of-erk1-2-signaling
#9
Zhao Liu, Hui Zhang, Sentai Ding, Shasha Qi, Shuai Liu, Dingqi Sun, Wei Dong, Lei Yin, Mingjiang Li, Xingbo Zhao, Jiaju Lu
The epithelial‑mesenchymal transition (EMT) is reported to have intimate crosstalk with androgen receptor (AR) signaling in prostate cancer (PCa) and is known to be responsible for castration resistance. Fibroblast growth factor/receptor (FGF/FGFR) signaling is also involved in tumor progression and EMT in multiple tissues. Several studies have investigated the role of βKlotho, an FGF/FGFR signaling co‑receptor in tumorigenesis. However, its role in PCa remains unknown. In the present study, the role of androgen in the EMT of PCa cells was examined by western blotting...
April 25, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29746859/long-term-continence-outcomes-in-men-undergoing-radical-prostatectomy-a-prospective-15-year-longitudinal-study
#10
Alex J Xu, Glen B Taksler, Elton Llukani, Herbert Lepor
PURPOSE: To examine the time dependent rates of urinary continence (UC) following open retropubic radical prostatectomy (ORRP). MATERIALS AND METHODS: 1,995 men undergoing RP were enrolled in a prospective, longitudinal outcomes study. The University of California, Los Angeles-Prostate Cancer Index Urinary Function Index (UCLA-PCI-UFS) was administered at baseline, 3, 6, 12, 24, 96, 120, and 180 months post-ORRP. Urinary continence was defined by <1 pad in 24 hours...
May 7, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29745091/upregulation-of-mir-191-promotes-cell-growth-and-invasion-via-targeting-timp3-in-prostate-cancer
#11
Xueling Wang, Zhimin Shi, Xiaoxia Liu, Ying Su, Weixia Li, Haiping Dong, Liwei Zhao, Manman Li, Yunxiao Wang, Xiu Jin, Zhongchao Huo
PURPOSE: Prostate cancer (PCa) is the most frequently malignant neoplasm in men. MicroRNAs (miRs) have been identified to play important biological roles in a variety of tumors. Several studies showed that miR-191 was involved in the development of different cancers, but its role in prostate cancer remains unclear. METHODS: Human PCa cell lines DU145, PC-3 and LNCAP, and benign prostate hyperplasia (BPH) and human prostate epithelial cell line RWPE-1 were used. The expression level of miR-191 in 48 paired prostate tumor and adjacent normal tissues was assessed along with the clinical patient features...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29741162/the-urinary-sarcosine-creatinine-ratio-is-a-potential-diagnostic-and-prognostic-marker-in-prostate-cancer
#12
Meng Wang, Lihui Zou, Jing Liang, Xin Wang, Dalei Zhang, Yuan Fang, Junhua Zhang, Fei Xiao, Ming Liu
BACKGROUND The aim of this study was to evaluate the role of the urinary sarcosine/creatinine ratio in the diagnosis and prognosis of prostate cancer, using a sarcosine oxidase assay. MATERIAL AND METHODS Urine samples were obtained from 203 patients with benign prostate hyperplasia (BPH) and 209 patients with prostate cancer. Levels of urinary sarcosine were measured using the sarcosine oxidase method. The urinary sarcosine/creatinine ratios were compared between the group of patients with BPH and the patients with prostate cancer...
May 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29738187/-influence-of-photoselective-vaporization-of-the-prostate-on-the-sexual-function-of-the-patient
#13
REVIEW
Hua-Jie Zhang, Guo-Sheng Yang
n recent years, photoselective vaporization of the prostate (PVP) has gained a wide clinical application in the treatment of benign prostatic hyperplasia (BPH) for its satisfactory effect, high safety, and low incidence of complications. With the improvement of living conditions, BPH patients are paying more attention to their sexual function, especially erectile function and ejaculatory problems instead of just focusing on the alleviation of lower urinary tract symptoms. Few studies of PVP, however, relate to its association with the sexual function of the patient and there is a certain controversy over the influence of PVP on it in the existing literature...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29738184/-correlation-between-tcm-syndrome-types-and-clinical-symptoms-of-benign-prostatic-hyperplasia-with-chronic-prostatitis
#14
Xin-Fei Huang, Ke-Qin Ning, Qing Wang, Tao Liu, Ying He, Jian-Guo Xue, Li-Qin Dai, Yong-Kang Zhu
Objective: To investigate the correlation between the syndrome types of traditional Chinese medicine (TCM) and clinical symptoms of benign prostatic hyperplasia (BPH) with chronic prostatitis (BPH-CP). METHODS: We selected 150 cases of BPH-CP in this study and divided them into 7 TCM syndrome types. Using univariate and multivariate logistic regression analyses, we studied the correlation of each TCM syndrome type with the age, disease course, prostate volume, postvoid residual urine volume (PVR), prostate-specific antigen (PSA) level, maximum urinary flow rate (Qmax), and International Prostate Symptoms Score (IPSS)...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29738178/-thulium-laser-vaporization-versus-transurethral-resection-of-the-prostate-and-risk-factors-for-postoperative-urethral-stricture
#15
Wen Song, Tao Wang, Qing Ling, Xia-Ming Liu, Zhong Chen, Xiao-Dong Song, Xiao-Lin Guo, Qian-Yuan Zhuang, Shao-Gang Wang, Ji-Hong Liu
Objective: To compare thulium laser vaporization of the prostate (TLVP) and transurethral resection of the prostate (TURP) in the treatment of benign prostate hyperplasia (BPH) analyze the risk factors for postoperative urethral stricture. METHODS: From June 2015 to June 2016, 210 BPH patients in our hospital underwent TURP (n = 126) or TLVP (n = 84). We followed up the patients for 6 months, compared the effects of the two surgical strategies and analyzed the risk factors for postoperative urethral stricture by multivariate logistic regression analysis...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29737501/safety-of-tamsulosin-a-systematic-review-of-randomized-trials-with-a-focus-on-women-and-children
#16
REVIEW
Steven A Kaplan, Bilal I Chughtai
INTRODUCTION: Although tamsulosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH), it has also been assessed in clinical studies for other conditions/symptoms and in other populations such as women and children. In this systematic review of randomized studies, the overall safety of tamsulosin was assessed, focusing on these understudied populations. METHODS: Literature searches were conducted using Embase, Medline, and PubMed (inception-December 2015)...
May 8, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29737092/-study-of-kinase-inhibitor-wp1066-on-the-stat3-jak2-of-prostate-stromal-cells
#17
Yun-Xiang Li, Jin-Ming Li, Qiang Wei, Zong-Ping Zhang, Ji Wu, An-Guo Wang
OBJECTIVE: To study the role of JAK2 signaling pathway in prostate stromal cells and the effect of inhibitor WP1066 on its expression. METHODS: The phosphorylation of JAK2 and STAT3 in prostate tissues of patients with benign prostatic hyperplasia (BHP) ( n =4) and severe histological prostatitis (HP) plus BPH ( n =4) was tested by using Western blot to verify the activation of their mediated signaling pathway. Kinase inhibitor WP1066 was added to prostate stromal cells to detect inhibition of the JAK2 and STAT3 activation launched by IL-6...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29736374/the-association-of-benign-prostatic-hyperplasia-with-lower-urinary-tract-stones-in-adult-men-a-retrospective-multicenter-study
#18
Jae Hung Jung, Jinsung Park, Won Tae Kim, Hong Wook Kim, Hyung Joon Kim, Sungwoo Hong, Hee Jo Yang, Hong Chung
Objective: To examine the relationship between benign prostatic hyperplasia (BPH) and the presence of lower urinary tract stones. Methods: We retrospectively reviewed the records of men with lower urinary tract stones who presented to three clinical centers in Korea over a 4-year period. We divided the patients into two groups based on the location of urinary stones: Group 1 (bladder calculi) and Group 2 (urethral calculi). We compared the characteristics of both groups and performed univariate and multivariate analyses with a logistic regression model to investigate the relationship between BPH and lower urinary tract stones...
April 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29733586/the-biphenyl-metabolizing-microbial-community-and-a-functional-operon-revealed-in-e-waste-contaminated-soil
#19
Longfei Jiang, Chunling Luo, Dayi Zhang, Mengke Song, Yingtao Sun, Gan Zhang
Primitive electronic waste (e-waste) recycling activities release massive amounts of persistent organic pollutants (POPs) and heavy metals into surrounding soils, posing a major threat to the ecosystem and human health. Microbes capable of metabolizing POPs play important roles in POPs remediation in soils, but their phylotypes and functions remain unclear. Polychlorinated biphenyls (PCBs), one of the main pollutants in e-waste contaminated soils, have drawn increasing attention due to their high persistence, toxicity, and bioaccumulation...
May 7, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29732451/gold-i-complexes-of-the-geminal-phosphinoborane-t-bu-2-pch-2-bph-2
#20
Devin H A Boom, Andreas W Ehlers, Martin Nieger, Marc Devillard, Ghenwa Bouhadir, Didier Bourissou, J Chris Slootweg
In this work, we explored the coordination properties of the geminal phosphinoborane t Bu2 PCH2 BPh2 ( 2 ) toward different gold(I) precursors. The reaction of 2 with an equimolar amount of the sulfur-based complex (Me2 S)AuCl resulted in displacement of the SMe2 ligand and formation of linear phosphine gold(I) chloride 3 . Using an excess of ligand 2 , bisligated complex 4 was formed and showed dynamic behavior at room temperature. Changing the gold(I) metal precursor to the phosphorus-based complex, (Ph3 P)AuCl impacted the coordination behavior of ligand 2 ...
April 30, 2018: ACS Omega
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