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https://www.readbyqxmd.com/read/28934186/opioid-overdose-outbreak-west-virginia-august-2016
#1
Joel Massey, Michael Kilkenny, Samantha Batdorf, Sarah K Sanders, Debra Ellison, John Halpin, R Matthew Gladden, Danae Bixler, Loretta Haddy, Rahul Gupta
On August 15, 2016, the Mayor's Office of Drug Control Policy in Huntington, West Virginia, notified the Cabell-Huntington Health Department (CHHD) of multiple calls regarding opioid overdose received by the emergency medical system (EMS) during 3 p.m.-8 p.m. that day. A public health investigation and response conducted by the West Virginia Bureau for Public Health (BPH) and CHHD identified 20 opioid overdose cases within a 53-hour period in Cabell County; all cases included emergency department (ED) encounters...
September 22, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28932300/androgen-receptor-expression-in-epithelial-and-stromal-cells-of-prostatic-carcinoma-and-benign-prostatic-hyperplasia
#2
Vanja Filipovski, Katerina Kubelka-Sabit, Dzengis Jasar, Vesna Janevska
BACKGROUND: Prostatic carcinoma (PCa) derives from prostatic epithelial cells. However stromal microenvironment, associated with malignant epithelium, also plays a role in prostatic carcinogenesis. Alterations in prostatic stromal cells contribute to the loss of growth control in epithelial cells that lead to progression of PCa. AIM: To analyse the differences between Androgen Receptor (AR) expression in both epithelial and stromal cells in PCa and the surrounding benign prostatic hyperplasia (BPH) and to compare the results with tumour grade...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28930560/structural-and-molecular-biology-of-psp94-its-significance-in-prostate-pathophysiology
#3
Jenifer H Anklesaria, Deepa R Mhatre, Smita D Mahale
Prostate secretory protein of 94 amino acids (PSP94), primarily found in the prostatic secretion, was originally isolated and purified from human seminal plasma. PSP94 has several putative biological functions and is considered a marker of prostate cancer (PCa). Here, we review the structural-functional relationships of PSP94, address its fungicidal activity and role as an inhibitor of sperm motility and protection from female immune surveillance, and review its role in tumor suppression. We also review the diagnostic assays that are developed for PSP94 for use in the diagnosis of PCa and use of such tests in the differential diagnosis of PCa from benign prostatic hyperplasia (BPH)...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28912601/phf7-a-novel-male-gene-influences-female-fecundity-and-population-growth-in-nilaparvata-lugens-st%C3%A3-l-hemiptera-delphacidae
#4
Lin-Quan Ge, Ting Xia, Bo Huang, Hao-Tian Gu, Qi-Sheng Song, Guo-Qing Yang, Fang Liu, Jin-Cai Wu
PHF7 exhibits male-specific expression in early germ cells, germline stem cells and spermatogonia in insects, and its expression promotes spermatogenesis in germ cells when they are present in a male soma. However, the influence of male-specific PHF7 on female reproductive biology via mating remains unclear. Thus, we investigated the potential impacts of male PHF7, existed in seminal fluid of Nilaparvata lugens (NlPHF7), on fecundity and population growth via mating. Our results revealed that suppressing male NlPHF7 expression by RNAi led to decreases in body weight, soluble accessory gland protein content, arginine content, and reproductive organ development in males, resulting in significant reduction of oviposition periods and fecundity in females, and significant decrease in body weight, fat body and ovarian protein content, yeast-like symbionts abundance, ovarian development and vitellogenin gene expression in their female mating partners...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28904902/technique-considerations-and-complication-management-in-transurethral-resection-of-the-prostate-and-photoselective-vaporization-of-the-prostate
#5
REVIEW
Charles Welliver, Sevann Helo, Kevin T McVary
The prevalence of lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) increases with age. While a variety of treatments are available for these men, endoscopic treatments are generally preferred for men with small to moderate size glands. Novel treatment options are continually introduced into this large market. However, the practicing urologist should have a well tested surgical option in regular practice that is applicable to a wide range of patients. Herein we discuss two well recognized surgical options that can be used for the majority of men with LUTS due to BPH who have failed medical management...
August 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28904679/knowledge-attitudes-and-screening-practices-regarding-prostatic-diseases-among-men-older-than-40-years-a-population-based-study-in-southwest-nigeria
#6
Rufus Wale Ojewola, Ezekiel Sofela Oridota, Olanrewaju Samuel Balogun, Ezra Olatunde Ogundare, Taiwo Opeyemi Alabi, Oluseyi Omotola Banjo, Adeyinka Laoye, Babatunde Adetunmbi, Bamidele Oludele Adebayo, Rotimi Oluyombo
INTRODUCTION: Despite the global increase in awareness of prostatic diseases resulting from widespread availability of screening tools, there is no evidence that the knowledge, attitudes and screening practices of Nigerian men have improved regarding prostatic diseases. METHODS: A descriptive cross-sectional study amongst 305 community-dwelling men. Respondents were selected using multi-staged sampling techniques. Knowledge, attitudes and screening practices were determined based on responses to a semi-structured KAP questionnaire...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28903581/geriatric-assessment-can-predict-outcomes-of-endoscopic-surgery-for-benign-prostatic-hyperplasia-in-elderly-patients
#7
Thomas Pichon, Cyrille Launay, Thibaut Culty, Denis Chautard, Nadine Collet, Nicolas Hoareau, Elena Brassart, Pierre Bigot, Olivier Beauchet, Abdel-Rahmene Azzouzi, Arnaud Cerruti, Souhil Lebdai
Ojectives: Surgical management of benign prostatic hyperplasia (BPH) in elderly patients is associated with higher morbidity and mortality. This arises the question of benefice and risk balance. We conducted a prospective observational study to evaluate the results of endoscopic surgery for BPH in elderly patients, according to geriatric assessment. PATIENTS AND METHODS: We included prospectively 60 patients over 75 years, with an indwelling catheter for acute or chronic retention, who were candidates to endoscopic surgery for BPH...
September 13, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28902866/5-year-long-term-efficacy-of-120-w-greenlight-photoselective-vaporization-of-the-prostate-for-benign-prostate-hyperplasia
#8
Juhyun Park, Sung Yong Cho, Min Chul Cho, Hyeon Jeong, Hwancheol Son
PURPOSE: To investigate 5-year long-term postoperative efficacy in benign prostate hyperplasia (BPH) following 120-W GreenLight high-performance system photoselective vaporization of the prostate (HPS-PVP). METHODS: This was a retrospective study of surgical outcomes in 159 men who underwent HPS-PVP and were followed over 60 months postoperatively. Definitions of treatment success were established based on the following three variables: international prostate symptom scores (IPSS), maximum flow rates (Qmax), and quality of life scores QoL)...
2017: PloS One
https://www.readbyqxmd.com/read/28901012/pharmacology-of-cognition-a-panacea-for-neuropsychiatric-disease
#9
EDITORIAL
Sarah J Bailey, Joanna C Neill, Paula M Moran
This article is part of a themed section on Pharmacology of Cognition: a Panacea for Neuropsychiatric Disease? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.19/issuetoc.
October 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28889714/-clinical-study-of-holep-for-the-patients-with-benign-prostatic-hyperplasia-who-are-on-oral-antithrombotics
#10
Takashi Matuoka, Issei Suzuki, Ryosuke Suzuki, Arinobu Fukunaga, Yoichiro Dohi, Yoshio Sugino, Koji Inoue, Mutsushi Kawakita
Recently, holmium laserenucleation of the prostate (HoLEP) was associated with less bleeding compared with transurethral resection of prostate. Since 2012, we have performed HoLEP for benign prostatic hyperplasia (BPH) under continuous oral antithrombotics (OA). Between October 2004 and March 2015, 54 patients with BPH underwent HoLEP while on OA at our hospital. Eight patients underwent HoLEP without OA cessation and 46 patients with temporary OA cessation. No significant between-group difference was observed in age, prostate volume, transitional zone prostate volume, operation time, resection weight, resection weight per minute, urethral catheter duration, Hb decrease on day 1 post- HoLEP, hospital stay after HoLEP, bleeding intraoperative rate, bleeding rate after HoLEP and transfusion rate...
August 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28882566/genetic-variations-in-ugt2b28-ugt2b17-ugt2b15-genes-and-the-risk-of-prostate-cancer-a-case-control-study
#11
Mohsen Habibi, Reza Mirfakhraie, Maryam Khani, Azadeh Rakhshan, Eznollah Azargashb, Farkhondeh Pouresmaeili
Glucuronidation is a major pathway for elimination of exogenous and endogenous compounds such as environmental carcinogens and androgens from the body. This biochemical pathway is mediated by enzymes called uridine diphosphoglucuronosyltransferases (UGTs). Null (del/del) genes polymorphisms in UGT2B17, and UGT2B28 and D85Y single-nucleotide polymorphism (SNP) of UGT2B15 have been reported to increase the risk of prostate cancer. The goal of this study was to determine the association of mentioned genetic variants with the risk of prostate cancer...
September 4, 2017: Gene
https://www.readbyqxmd.com/read/28879692/safety-and-effectiveness-of-once-daily-tadalafil-5-mg-therapy-in-korean-men-with-benign-prostatic-hyperplasia-lower-urinary-tract-symptoms-in-a-real-world-clinical-setting-results-from-a-post-marketing-surveillance-study
#12
Ji Eon Won, Ji Yeon Chu, Hyunah Caroline Choi, Yun Chen, Hyun Jun Park, Héctor José Dueñas
PURPOSE: The aim of this study was to investigate the safety and effectiveness of tadalafil 5 mg once daily (quaque die [everyday], QD) among Korean men with benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) in a real-world clinical setting. MATERIALS AND METHODS: This was a single-country, prospective, observational cohort study in which patients newly prescribed tadalafil 5 mg QD for the treatment of BPH/LUTS were followed-up for 12±2 or 24±2 weeks, or to the last treatment, during post-marketing surveillance...
September 6, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/28877372/desquamation-takes-center-stage-at-the-origin-of-proliferative-inflammatory-atrophy-epithelial-mesenchymal-transition-and-stromal-growth-in-benign-prostate-hyperplasia
#13
Danilo Ferrucci, Manoel F Biancardi, Umar Nishan, Rafaela Rosa-Ribeiro, Hernandes F Carvalho
In this commentary we propose a relationship between desquamation, initially described as the collective detachment and deletion of epithelial cell in the prostate gland after castration, and proliferative inflammatory atrophy (PIA) and stromal growth in benign prostate hyperplasia (BPH). First, in response to diverse stimuli, including inflammatory mediators, epithelial cells desquamate and leave a large surface of the luminal side of the basement membrane (BM) exposed. Basal cells are activated into intermediate-type cells, which change morphology to cover and remodel the exposed BM (simple atrophy) to a new physiological demand (such as in the hypoandrogen environment, simulated by surgical and/or chemical castration) and/or to support re-epithelialization (under normal androgen levels)...
September 6, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28871414/postoperative-urinary-retention-after-inguinal-hernia-repair-a-single-institution-experience
#14
A B Blair, A Dwarakanath, A Mehta, H Liang, X Hui, C Wyman, J P P Ouanes, H T Nguyen
PURPOSE: Inguinal hernia repair is a common general surgery procedure with low morbidity. However, postoperative urinary retention (PUR) occurs in up to 22% of patients, resulting in further extraneous treatments.This single institution series investigates whether patient comorbidities, surgical approaches, and anesthesia methods are associated with developing PUR after inguinal hernia repairs. METHODS: This is a single institution retrospective review of inguinal hernia from 2012 to 2015...
September 4, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28870994/conditional-deletion-of-ell2-induces-murine-prostate-intraepithelial-neoplasia
#15
Laura E Pascal, Khalid Z Masoodi, June Liu, Xiaonan Qiu, Qiong Song, Yujuan Wang, Yachen Zang, Tiejun Yang, Yao Wang, Lora H Rigatti, Uma Chandran, Leandro M Colli, Ricardo Z N Vencio, Yi Lu, Jian Zhang, Zhou Wang
Elongation factor, RNA polymerase II, 2 (ELL2) is an RNA Pol II elongation factor with functional properties similar to ELL that can interact with the prostate tumor suppressor EAF2. In the prostate, ELL2 is an androgen response gene that is upregulated in benign prostatic hyperplasia (BPH). We recently showed that ELL2 loss could enhance prostate cancer cell proliferation and migration, and that ELL2 gene expression was downregulated in high Gleason score prostate cancer specimens. Here, prostate-specific deletion of ELL2 in a mouse model revealed a potential role for ELL2 as a prostate tumor suppressor in vivoEll2-knockout mice exhibited prostatic defects including increased epithelial proliferation, vascularity and PIN lesions similar to the previously determined prostate phenotype in Eaf2-knockout mice...
November 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28870918/the-diagnostic-significance-of-serum-alcohol-dehydrogenase-isoenzymes-and-aldehyde-dehydrogenase-activity-in-prostate-cancer-patients
#16
Karolina Orywal, Wojciech Jelski, Tadeusz Werel, Maciej Szmitkowski
BACKGROUND/AIM: The aim of this study was to investigate a potential role of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as tumor markers for prostate cancer (PCa). MATERIALS AND METHODS: Serum samples were obtained from 52 patients with PCa, 34 patients with benign prostatic hyperplasia (BPH) and 60 healthy subjects. Class III and IV of ADH and total ADH activity were measured by the photometric method. For measurement of class I and II ADH and ALDH activity, the fluorometric method was employed...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28869721/the-utility-and-feasibility-of-assessing-sleep-disruption-in-a-men-s-health-clinic-using-a-mobile-health-platform-device-a-pilot-study
#17
Hai H Le, Rachel Marie E Salas, Alyssa Gamaldo, Kevin L Billups, Peter Dziedzic, Seulah Choi, Neftali Bermudez, Roland J Thorpe, Charlene E Gamaldo
INTRODUCTION: Evidence linking sleep disruption and sexual dysfunction in men is mounting; yet the characterisation of sleep patterns and complaints utilising a clinically feasible method within this patient population remain largely under-reported. AIM: A pilot study aiming to demonstrate a clinically feasible method to characterise the sleep patterns and complaints in a representative sample of patients treated in a men's health clinic. METHODS: Male patients (n = 48) completed a battery of validated sleep questionnaires using an mHealth mobile platform, MySleepScript, at the Johns Hopkins Men's Health and Vitality Center...
September 4, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28865604/efficacy-of-holmium-laser-enucleation-of-the-prostate-holep-in-men-with-bladder-outlet-obstruction-boo-and-non-neurogenic-bladder-dysfunction
#18
Jong Hyun Pyun, Sung Gu Kang, Seok Ho Kang, Jun Cheon, Je Jong Kim, Jeong Gu Lee
We aimed to compare the short-term outcomes of men who had urodynamic evidence of detrusor underactivity (DU) or detrusor overactivity (DO) of a non-neurogenic etiology as well as bladder outlet obstruction (BOO) and who underwent Holmium Laser Enucleation of the prostate (HoLEP). A database of 322 patients who underwent HoLEP between 2010 and 2014 was analyzed. Patients were classified into three groups according to the results of a preoperative urodynamic study. Preoperative parameters such as International Prostate Symptom Score (IPSS), Quality of Life (QoL) index, IPSS grade, uroflowmetry were compared with postoperative parameters measured at 6 months...
September 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28861736/identification-and-fine-mapping-of-a-new-gene-bph31-conferring-resistance-to-brown-planthopper-biotype-4-of-india-to-improve-rice-oryza-sativa-l
#19
G D Prahalada, N Shivakumar, H C Lohithaswa, D K Sidde Gowda, G Ramkumar, Sung-Ryul Kim, C Ramachandra, Shailaja Hittalmani, Trilochan Mohapatra, Kshirod K Jena
BACKGROUND: Rice (Oryza sativa L.) is the staple food for more than 3.5 billion people, mainly in Asia. Brown planthopper (BPH) is one of the most destructive insect pests of rice that limits rice production. Host-plant resistance is one of the most efficient ways to overcome BPH damage to the rice crop. RESULTS: BPH bioassay studies from 2009 to 2015 conducted in India and at the International Rice Research Institute (IRRI), Philippines, revealed that the cultivar CR2711-76 developed at the National Rice Research Institute (NRRI), Cuttack, India, showed stable and broad-spectrum resistance to several BPH populations of the Philippines and BPH biotype 4 of India...
August 31, 2017: Rice
https://www.readbyqxmd.com/read/28861405/procedural-techniques-and-multicenter-postmarket-experience-using-minimally-invasive-convective-radiofrequency-thermal-therapy-with-rez%C3%A5-m-system-for-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia
#20
Micheal F Darson, Erik E Alexander, Zvi J Schiffman, Michael Lewitton, Robert A Light, Mark A Sutton, Carlos Delgado-Rodriguez, Ricardo R Gonzalez
OBJECTIVE: This report evaluates clinical experience with the Rezūm system after US Food and Drug Administration clearance in consecutive cases accrued by multiple community urologists for the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Treatment techniques for transurethral convective radiofrequency water-vapor thermal therapy and outcomes with up to 12 months' follow-up are presented. MATERIALS AND METHODS: A total of 131 patients with moderate-severe LUTS were included in a retrospective analysis of BPH procedures with the Rezūm system...
2017: Research and Reports in Urology
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