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Enterococcus faecalis endocarditis

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https://www.readbyqxmd.com/read/28096164/pharmacodynamics-of-ceftaroline-plus-ampicillin-against-enterococcus-faecalis-in-an-in-vitro-pharmacokinetic-pharmacodynamic-model-of-simulated-endocardial-vegetations
#1
Brian J Werth, Laura M Shireman
The combination of ampicillin plus ceftaroline has been suggested to be more reliably synergistic against E. faecalis than ampicillin plus ceftriaxone using time-kill methods. The purpose of this study was to determine if this trend persists in a two-compartment-model of simulated endocardial vegetations(SEV) using clinically relevant pharmacokinetic exposures of these antimicrobials. Three clinically-derived E. faecalis strains were included in the study. The MICs of study antimicrobials were determined by broth microdilution...
January 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27989071/broad-range-16s-rdna-pcr-on-heart-valves-in-infective-endocarditis
#2
Manica Müller Premru, Tatjana Lejko Zupanc, Tomislav Klokočovnik, Eva Ruzić Sabljić, Tjaša Cerar
BACKGROUND: Infective endocarditis (IE) is diagnosed by blood and/or resected valve cultivation and echocardiographic findings, as defined by the Duke criteria. Unfortunately, cultures may be negative due to prior antibiotic therapy or fastidious or slow-growing microorganisms. The study aim was to investigate the value of the broad-range polymerase chain reaction (PCR) in addition to blood and valve culture for the detection of causative microorganisms. METHODS: Between February 2012 and March 2015, valve samples from 36 patients undergoing cardiac surgery were analyzed; of these patients, 26 had a preoperative diagnosis of IE and 10 served as controls...
March 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27979420/procalcitonin-levels-in-bloodstream-infections-caused-by-different-sources-and-species-of-bacteria
#3
Sheng Tao Yan, Li Chao Sun, Hong Bing Jia, Wen Gao, Jian Ping Yang, Guo Qiang Zhang
OBJECTIVE: The aim of this study was to evaluate procalcitonin (PCT) diagnostic accuracy in discriminating gram-negative (GN) from gram-positive (GP) bloodstream infections and determining the relationship between PCT levels, infection sites, and pathogen types. METHODS: Clinical and laboratory data were collected from patients with blood culture (BC)-positive sepsis between January 2014 and December 2015. PCT levels at different infection sites were compared, as was the presence of GN and GP bloodstream infection...
December 10, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27916708/relationship-between-enterococcus-faecalis-infective-endocarditis-and-colorectal-neoplasm-preliminary-results-from-a-cohort-of-154-patients
#4
Juan M Pericàs, Juan Corredoira, Asunción Moreno, M José García-País, Carlos Falces, Ramón Rabuñal, Carlos A Mestres, M Pilar Alonso, Francesc Marco, Eduard Quintana, Manel Almela, Juan C Paré, Jaume Llopis, Antoni Castells, José M Miró
INTRODUCTION AND OBJECTIVES: The association between Streptococcus bovis group infective endocarditis and colorectal neoplasm (CRN) is well-known. However, no studies have assessed the association between Enterococcus faecalis infective endocarditis (EFIE) and CRN. We aimed to determine whether the prevalence of CRN is higher in patients with EFIE and an unclear source of infection than in patients with EFIE and a known source of infection or in the general population. METHODS: Retrospective analysis of a cohort of 154 patients with definite EFIE (109 with an unclear source of infection and 45 with an identified source) from 2 Spanish teaching hospitals to determine the prevalence of CRN and other colorectal diseases...
December 1, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27914083/antibody-guided-molecular-imaging-of-infective-endocarditis
#5
Kenneth L Pinkston, Peng Gao, Kavindra V Singh, Ali Azhdarinia, Barbara E Murray, Eva M Sevick-Muraca, Barrett R Harvey
In this protocol, we describe the application of using a high affinity monoclonal antibody generated against the major pilin protein component of the pilin structure of Enterococcus faecalis as a PET imaging agent for enterococcal endocarditis detection. The anti-pilin -mAb 64Cu conjugate was able to specifically label enterococcal endocarditis vegetation in vivo in a rodent endocarditis model. By targeting pili, a covalently linked surface antigen extending from the bacterial surface, we provided evidence that gram-positive pilin represent a logical surface antigen to define or target an infectious agent for molecularly guided imaging...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27797843/endocarditis-and-monocular-blindness
#6
Jack Andrews, Shyamanga Borooah
A man aged 77 years with postrenal transplant lymphoproliferative disease was admitted with high fever, elevated inflammatory markers and a heart murmur. Blood cultures grew Enterococcus faecalis and he was found to have mitral valve endocarditis on echocardiogram and subsequently started on appropriate antibiotics. 5 days into treatment, he developed ocular symptoms and 3 days later, he had irreversible monocular visual loss. He was seen by the ophthalmology team who diagnosed endogenous endopthalmitis secondary to bacteraemic spread from his endocarditis...
October 26, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27617012/dispersion-of-the-vancomycin-resistance-genes-vana-and-vanc-of-enterococcus-isolated-from-nile-tilapia-on-retail-sale-a-public-health-hazard
#7
Kamelia M Osman, Mohamed N Ali, Ismail Radwan, Fatma ElHofy, Ahmed H Abed, Ahmed Orabi, Nehal M Fawzy
Although normally regarded harmless commensals, enterococci may cause a range of different infections in humans, including urinary tract infections, sepsis, and endocarditis. The acquisition of vancomycin resistance by enterococci (VRE) has seriously affected the treatment and infection control of these organisms. VRE are frequently resistant to all antibiotics that are effective treatment for vancomycin-susceptible enterococci, which leaves clinicians treating VRE infections with limited therapeutic options...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27500132/prosthetic-aortic-valve-endocarditis-with-left-main-coronary-artery-embolism-a-case-report-and-review-of-the-literature
#8
Hafeez Ul Hassan Virk, Faisal Inayat, Salman Farooq, Ali Raza Ghani, Ghazi A Mirrani, Muhammed Waqas Athar
CONTEXT: Coronary embolization is potentially a fatal sequela of endocarditis. Although the primary cause of acute coronary syndrome is atherosclerotic disease, it is imperative to consider septic embolism as an etiological factor. CASE REPORT: Herein, we report a case of ventricular fibrillation and ST-segment depression myocardial infarction occurring in a patient who initially presented with fever and increased urinary frequency. Coronary angiography revealed new 99% occlusion of the left main coronary artery (LMCA)...
June 2016: North American Journal of Medical Sciences
https://www.readbyqxmd.com/read/27464216/colorectal-adenomas
#9
LETTER
Ester Castellsagué, Barbara Rivera, William D Foulkes
No abstract text is available yet for this article.
July 28, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27464215/colorectal-adenomas
#10
LETTER
Steven H Itzkowitz, David A Ahlquist
No abstract text is available yet for this article.
July 28, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27464214/colorectal-adenomas
#11
LETTER
Juan M Pericàs, Juan Corredoira, José M Miró
No abstract text is available yet for this article.
July 28, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27464213/colorectal-adenomas
#12
LETTER
Williamson B Strum
No abstract text is available yet for this article.
July 28, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27391962/bacteraemia-during-transurethral-resection-of-the-prostate-what-are-the-risk-factors-and-is-it-more-common-than-we-think
#13
Amar Raj Mohee, Deborah Gascoyne-Binzi, Robert West, Selina Bhattarai, Ian Eardley, Jonathan A T Sandoe
The aim of this work was to investigate the microbial causes, incidence, duration, risk factors and clinical implications of bacteraemia occurring during transurethral resection of the prostate (TURP) surgery to better inform prophylaxis strategies. An ethically approved, prospective, cohort study of patients undergoing TURP was conducted. Clinical information and follow-up details were collected using standardized data collection sheets. Blood was obtained for culture at 6 different time points peri-procedure...
2016: PloS One
https://www.readbyqxmd.com/read/27374863/a-case-of-infective-endocarditis-and-pyogenic-spondylitis-after-transrectal-ultrasound-guided-prostate-biopsy
#14
Yoshiki Hiyama, Satoshi Takahashi, Teruhisa Uehara, Koji Ichihara, Jiro Hashimoto, Naoya Masumori
We report a patient with infective endocarditis and pyrogenic spondylitis occurring simultaneously. The patient was a 59-year-old man. He was suspected of having prostate cancer due to a high prostate-specific antigen concentration noted in a checkup. He then underwent a transrectal ultrasound guided prostate biopsy with cefotiam as antimicrobial prophylaxis. He had a fever higher than 38 °C and lumbar pain for a few days after the biopsy. Enterococcus faecalis was isolated from 2 sets of blood culture. Magnetic resonance imaging revealed an abnormal image at C7/Th1 with a signal decrease in T1-weighted sequences and signal increase in T2-weighted sequences that were suspected to be due to bone destruction...
November 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27307506/risk-factors-of-endocarditis-in-patients-with-enterococcus-faecalis-bacteremia-external-validation-of-the-nova-score
#15
Anders Dahl, Trine K Lauridsen, Magnus Arpi, Lars L Sørensen, Christian Østergaard, Peter Sogaard, Niels E Bruun
BACKGROUND: The NOVA score is a recently developed diagnostic tool used to identify patients with increased risk of infective endocarditis (IE) among patients with Enterococcus faecalis bacteremia. We aimed to validate the NOVA score and to identify risk factors for IE. METHODS: From 1 January 2010 to 31 December 2013, we included 647 consecutive patients with E. faecalis bacteremia. The NOVA score was used in a slightly adapted form; 2/2 positive blood cultures resulted in 5 points, unknown origin of infection in 4 points, prior valve disease in 2 points, and heart murmur in 1 point...
September 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27249815/anterior-mitral-valve-aneurysm-a-rare-sequelae-of-aortic-valve-endocarditis
#16
Rajesh Janardhanan, Muhammad Umar Kamal, Irbaz Bin Riaz, M Cristy Smith
UNLABELLED: SummaryIn intravenous drug abusers, infective endocarditis usually involves right-sided valves, with Staphylococcus aureus being the most common etiologic agent. We present a patient who is an intravenous drug abuser with left-sided (aortic valve) endocarditis caused by Enterococcus faecalis who subsequently developed an anterior mitral valve aneurysm, which is an exceedingly rare complication. A systematic literature search was conducted which identified only five reported cases in the literature of mitral valve aneurysmal rupture in the setting of E...
March 2016: Echo Research and Practice
https://www.readbyqxmd.com/read/27207984/rare-case-of-simultaneous-enterococcal-endocarditis-and-prosthetic-joint-infection
#17
Sean I Tracy, Sherry-Ann Brown, John T Ratelle, Anjali Bhagra
A 59-year-old man was admitted with a 3-month history of daily fevers as well as bilateral knee pain and swelling. Medical history was significant for bilateral knee arthroplasties 4 years prior to admission. Two sets of peripheral blood cultures as well as bilateral knee synovial fluid grew Enterococcus faecalis within 10 hours. Transoesophageal echocardiography revealed aortic and mitral valve vegetations suggestive of infectious endocarditis, with severe regurgitation secondary to large size. The patient's hospitalisation was complicated by acute heart failure, necessitating emergent mitral valve repair and aortic valve replacement, followed shortly thereafter by bilateral total knee arthroplasty resection with placement of antibiotic spacers...
May 20, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27094238/first-japanese-case-of-infectious-endocarditis-due-to-enterococcus-faecalis-small-colony-variants
#18
Shinji Ogihara, Ryoichi Saito, Etsuko Sawabe, Michio Hagihara, Shuji Tohda
A male patient was admitted to our hospital due to infectious endocarditis. He had been treated with levofloxacin for 6 weeks, sulbactam/cefoperazone for 4 weeks, and benzylpenicillin for 2 days prior to valve replacement surgery. Gram-positive cocci, with morphology consistent with γ-Streptococcus, were detected in blood cultures obtained at admission, as well as in vegetation obtained from the aortic valve. However, the strain could not be identified using biochemical methods. Sequencing of the 16S rRNA gene indicated that the culture was a small-colony variant of Enterococcus faecalis...
October 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/26967674/enterococcus-faecalis-ebp-pili-are-important-for-cell-cell-aggregation-and-intraspecies-gene-transfer
#19
Sabina Leanti La Rosa, Maria Camila Montealegre, Kavindra V Singh, Barbara E Murray
Enterococcus faecalis is an opportunistic pathogen that ranks among the leading causes of biofilm-associated infections. We previously demonstrated that the endocarditis- and biofilm-associated pili (Ebp) of E. faecalis play a major role in biofilm formation, adherence to abiotic surfaces and experimental infections. In this study, derivatives of E. faecalis strain OG1 were engineered to further characterize functions of Ebp pili. Loss of pili resulted in a 36-fold decrease in the number of closely associated cells when OG1RFΔebpABC was mixed with OG1SSpΔebpABC, compared with mixing the Ebp+ parental strains...
May 2016: Microbiology
https://www.readbyqxmd.com/read/26926624/ampicillin-in-combination-with-ceftaroline-cefepime-or-ceftriaxone-demonstrates-equivalent-activities-in-a-high-inoculum-enterococcus-faecalis-infection-model
#20
Megan K Luther, Louis B Rice, Kerry L LaPlante
Ampicillin-ceftriaxone combination therapy has become a predominant treatment for serious Enterococcus faecalis infections, such as endocarditis. Unfortunately, ceftriaxone use is associated with future vancomycin-resistant enterococcus colonization. We evaluated E. faecalis in an in vitro pharmacodynamic model against simulated human concentration-time profiles of ampicillin plus ceftaroline, cefepime, ceftriaxone, or gentamicin. Ampicillin-cefepime and ampicillin-ceftaroline demonstrated activities similar to those of ampicillin-ceftriaxone against E...
May 2016: Antimicrobial Agents and Chemotherapy
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