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Potassium ascorbate cancer

Giovanni Vanni Frajese, Monica Benvenuto, Massimo Fantini, Elena Ambrosin, Pamela Sacchetti, Laura Masuelli, Maria Gabriella Giganti, Andrea Modesti, Roberto Bei
Ascorbic acid (A) has been demonstrated to exhibit anti-cancer activity in association with chemotherapeutic agents. Potassium (K) is a regulator of cellular proliferation. In the present study, the biological effects of A and K bicarbonate, alone or in combination (A+K), on breast cancer cell lines were evaluated. The survival of cancer cells was determined by sulforhodamine B cell proliferation assay, while analysis of the cell cycle distribution was conducted via fluorescence-activated cell sorting. In addition, the expression of signaling proteins was analyzed upon treatment...
June 2016: Oncology Letters
Bhupendra M Mistry, Rahul V Patel, Young-Soo Keum, Doo Hwan Kim
7-(4-Bromobutoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one, obtained from chrysin with 1,4-dibromobutane, was combined with a wide range of 6-substituted 2-aminobenzthiazoles, which had been prepared from the corresponding anilines with potassium thiocyanate. Free radical scavenging efficacies of newer analogues were measured using DPPH and ABTS assays, in addition to the assessment of their anticancer activity against cervical cancer cell lines (HeLa and CaSki) and ovarian cancer cell line (SK-OV-3) implementing the SRB assay...
December 1, 2015: Bioorganic & Medicinal Chemistry Letters
Sadegh Fattahi, Ebrahim Zabihi, Zeinab Abedian, Roghayeh Pourbagher, Ali Motevalizadeh Ardekani, Amrollah Mostafazadeh, Haleh Akhavan-Niaki
Phenolic compounds including flavonoids and phenolic acids are plants secondary metabolites. Due to their ability to act as antioxidant agents, there is a growing interest to use those components in traditional medicine for cancer prevention or treatment. The aim of this study was to measure the amounts of total phenolics and flavonoids as well as anti-proliferative effect of aqueous extract of Stinging nettle on BT-474 and Hela cell lines. The amounts of phenolics content and total flavonoids were determined by folin ciocalteu and aluminium chloride methods, respectively...
2014: International Journal of Molecular and Cellular Medicine
Cecilia Anichini, Federica Lotti, Alice Pietrini, Caterina Lo Rizzo, Mariangela Longini, Fabrizio Proietti, Cosetta Felici, Giuseppe Buonocore
BACKGROUND: Costello syndrome is a rare genetic condition characterized by coarse facies, short stature, loose folds of skin especially on hands and feet, severe feeding difficulties and failure to thrive. Other features include cardiac anomalies, developmental disability and increased risk of neoplasms. Given the link between oxidative stress (OS) and carcinogenesis, we tested the hypothesis that OS occurs in this syndrome, supposing its role both in cancer development and in other clinical features...
February 2013: Anticancer Research
Carol E O'Neil, Theresa A Nicklas, Gail C Rampersaud, Victor L Fulgoni
BACKGROUND: Consumption of 100% orange juice (OJ) has been positively associated with nutrient adequacy and diet quality, with no increased risk of overweight/obesity in children; however, no one has examined these factors in adults. The purpose of this study was to examine the association of 100% OJ consumption with nutrient adequacy, diet quality, and risk factors for metabolic syndrome (MetS) in a nationally representative sample of adults. METHODS: Data from adults 19+ years of age (n = 8,861) participating in the National Health and Nutrition Examination Survey 2003-2006 were used...
2012: Nutrition Journal
Cecilia Anichini, Caterina Lo Rizzo, Mariangela Longini, Guido Paoli, Rosanna Maria di Bartolo, Fabrizio Proietti, Giuseppe Buonocore
BACKGROUND: Beckwith-Wiedemann Syndrome (BWS) is a genomic imprinting disorder characterized by overgrowth and increased risk of malignancy. We studied the oxidative stress (OS) pattern of our patients with BWS and administered, for the first time, potassium ascorbate with ribose (PAR) once a day as long-term therapy in order to correct the effects induced by free radicals. PATIENTS AND METHODS: We describe the clinical features of three patients examined every three months in our clinic...
November 2011: Anticancer Research
Xiao-Rong Li, Bo Wang, Jing-Juan Xu, Hong-Yuan Chen
A newly developed electrochemical biosensor for the determination of superoxide anions (O(2)˙(-)) released from cancer cells using potassium-doped multi-walled carbon nanotubes (KMWNTs)-1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM]PF(6)) ionic liquid composite gels is demonstrated. The KMWNTs-[BMIM]PF(6) can electrocatalyze oxygen reduction to generate a strong current signal in neutral solution. Compared with KMWNTs without [BMIM]PF(6) or MWNTs-[BMIM]PF(6) composites, the KMWNTs-[BMIM]PF(6) can enhance the oxygen reduction peak current by 6...
December 2011: Nanoscale
F Bravi, J Polesel, C Bosetti, R Talamini, E Negri, L Dal Maso, D Serraino, C La Vecchia
OBJECTIVE: several studies have shown an inverse relation between vegetable and fruit intake and pancreatic cancer, but no specific beneficial component of such foods has been consistently identified. We considered the role of 15 selected vitamins and carotenoids and 6 minerals on pancreatic cancer risk in an Italian case-control study. METHODS: subjects were 326 patients with incident pancreatic cancer and 652 controls, admitted to the same hospitals as cases for acute conditions...
January 2011: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Sushil Kumar, Roli Budhwar, Akanksha Nigam, Shivam Priya
Alpha-lipoic acid (LA), the metabolic antioxidant, was evaluated for its potential to protect against Cr(6+)-induced DNA damage. Potassium dichromate was administered to Swiss albino mice orally ad libitum at the doses of 5, 10 or 25 mg/kg body weight in drinking water to set DNA damage in cells, which was characterized in mouse peripheral blood mononuclear cells and bone marrow cells using single-cell gel electrophoresis and analyses of generated comets for Tail moment, Tail DNA and Tail length. DNA damage was dose dependent...
November 2009: Mutagenesis
Diego A Moreno, Carmen López-Berenguer, Cristina García-Viguera
Numerous epidemiological studies indicate that Brassica vegetables in general and broccoli in particular protect humans against cancer; they are rich sources of glucosinolates and possess a high content on flavonoids, vitamins, and mineral nutrients. The contents of total intact glucosinolates, total phenolics, vitamin C, and minerals (potassium, sodium, calcium, magnesium, iron, manganese, zinc, and copper) in the edible portions of freshly harvested broccoli (florets), which was subjected to stir-frying treatments, were evaluated...
January 2007: Journal of Food Science
Mindy Reynolds, Anatoly Zhitkovich
Ascorbate (Asc) plays a key role in reductive activation of carcinogenic chromium(VI) in vivo. In addition to much higher rates (t(1/2) = 1 min for 1 mM Asc), its reactions at physiological conditions differ from other reducers by low yields of Cr(V) intermediates. Human cells in culture are severely Asc deficient, which results in distorted metabolism and potentially abnormal responses to Cr(VI). We found that restoration of physiological Asc levels in human lung cells (primary IMR90 fibroblasts and epithelial H460 cells) increased clonogenic lethality and apoptosis by Cr(VI)...
July 2007: Carcinogenesis
Qing H Meng, William C Irwin, Kishore Visvanathan
Vitamin C interferes with assays involving the redox-reaction. However, the interference of Vitamin C with electrolytes has not been reported. In the present case, we describe a 61-year-old lady with severe electrolyte abnormalities after administration of high doses of vitamin C. This patient, who had terminal colon cancer, presented to hospital with anuria. Her electrolytes were extremely abnormal (determined on the Beckman Synchron LX20): serum sodium 200 mmol/L, potassium 7.0 mmol/L, and chloride 50 mmol/L...
2005: Clinical Chemistry and Laboratory Medicine: CCLM
F P Cappuccio, E Rink, L Perkins-Porras, C McKay, S Hilton, A Steptoe
BACKGROUND AND AIM: High fruit and vegetable intake is associated with health benefits for cancer and cardiovascular disease. An increase is therefore integral in recommendations for the prevention of chronic disease. However, measuring intake requires either extensive dietary assessment or the measurement of specific bio-markers which is neither cheap nor feasible for the routine assessment of an individual's diet in a community or primary care setting. Within the context of a study evaluating a dietary counselling programme to increase fruit and vegetable intake our aim was to assess the use of a simple tool to estimate fruit and vegetable intake...
February 2003: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
N M McKeown, N E Day, A A Welch, S A Runswick, R N Luben, A A Mulligan, A McTaggart, S A Bingham
BACKGROUND: The validity of dietary assessment methods should be established before diet-disease associations are reported. OBJECTIVE: Our objective was to validate a 7-d food diary and a food-frequency questionnaire (FFQ) against independent biomarkers of intake in urine (nitrogen, potassium, and sodium) and blood (plasma ascorbic acid). DESIGN: A total of 146 healthy middle-aged men and women were recruited from the European Prospective Investigation into Cancer UK Norfolk cohort, a free-living cohort of approximately 25000 persons...
August 2001: American Journal of Clinical Nutrition
F Siassi, Z Pouransari, P Ghadirian
The purpose of this study was to investigate the possible contribution of different dietary nutrients in the development of esophageal cancer (EC) in the Caspian littoral of Iran. Forty-one cases and 145 members of their households were matched for age and gender with 40 non-blood-relative controls and 130 members of their households for their nutrient intake. A standard 24-hour dietary recall questionnaire was used to estimate the daily intake of energy, protein, P, Fe, Na, K, vitamins C and A, thiamin, riboflavin, and niacin...
2000: Cancer Detection and Prevention
E Negri, S Franceschi, C Bosetti, F Levi, E Conti, M Parpinel, C La Vecchia
The relation between selected micronutrients and oral and pharyngeal cancer risk was investigated using data from a case-control study conducted between January 1992 and November 1997 in Italy and Switzerland. Cases were 754 incident, histologically confirmed oral cancers (344 of the oral cavity and 410 of the pharynx) admitted to the major teaching and general hospitals in the study areas. Controls were 1,775 subjects with no history of cancer admitted to hospitals in the same catchment areas for acute, non-neoplastic diseases...
April 1, 2000: International Journal of Cancer. Journal International du Cancer
R Goldman, G H Claycamp, M A Sweetland, A V Sedlov, V A Tyurin, E R Kisin, Y Y Tyurina, V B Ritov, S L Wenger, S G Grant, V E Kagan
Various types of cancer occur in peroxidase-rich target tissues of animals exposed to aryl alcohols and amines. Unlike biotransformation by cytochrome P450 enzymes, peroxidases activate most substrates by one-electron oxidation via radical intermediates. This work analyzed the peroxidase-dependent formation of phenoxyl radicals in HL-60 cells and its contribution to cytotoxicity and genotoxicity. The results showed that myeloperoxidase-catalyzed redox cycling of phenol in HL-60 cells led to intracellular formation of glutathionyl radicals detected as GS-DMPO nitrone...
November 1999: Free Radical Biology & Medicine
S A Bingham
Biomarkers of nutrition intake were used to validate the dietary assessments proposed for use in the European prospective study of diet and cancer (EPIC). In the UK validation studies, the accuracy of several tested methods was assessed with weighed food records and biomarkers, 24 h urine nitrogen, potassium and plasma carotenoids and vitamin C. Correlations between dietary nitrogen intake from weighed food records and 24 h urine excretion were high (0.78-0.87). The correlations between nitrogen from estimated food diaries and urinary nitrogen were r = 0...
April 1997: European Journal of Cancer Prevention
J M Frémy, M J Castegnaro, E Gleizes, M De Meo, M Laget
Patulin is immunosuppressive and there is limited evidence of its carcinogenicity in experimental animals. The International Agency for Research on Cancer (IARC) initiated a programme for the development of degradation techniques for the commonly investigated mycotoxins. As a part of this programme, the following techniques were tested for the degradation of patulin: treatment with ammonia, treatment with ascorbic acid, and treatment with potassium permanganate in acidic or in alkaline conditions. Patulin analysis was performed by using HPLC with UV detection...
May 1995: Food Additives and Contaminants
A W Bull, A D Burd, N D Nigro
The level of O6-methylguanine (O6MeGua) in the colonic DNA of rats treated with 1,2-dimethylhydrazine was determined. The effect of various tumorigenesis inhibitors on the formation of this modified base was also studied. Rats were given a single s.c. injection of 1,2-[14C]dimethylhydrazine. Six hr later, they were killed, and colonic DNA was extracted and analyzed by high-pressure liquid chromatography. The inhibitors tested were disulfiram (DSF), pyrazole, sodium selenite, butylated hydroxyanisole, butylated hydroxytoluene, potassium ascorbate, and 13-cis-retinoic acid...
December 1981: Cancer Research
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