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Neuroadaptagen amino acid therapy

Merlene Miller, Amanda L C Chen, Stan D Stokes, Susan Silverman, Abdalla Bowirrat, Matthew Manka, Debra Manka, David K Miller, Kenneth Perrine, Thomas J H Chen, John A Bailey, William Downs, Roger L Waite, Margaret A Madigan, Eric R Braverman, Uma Damle, Mallory Kerner, John Giordano, Siobhan Morse, Marlene Oscar-Berman, Debmalya Barh, Kenneth Blum
Substance use disorders (SUD) are inheritable and the culprit is hypodopaminergic function regulated by reward genes. We evaluated a natural dopaminergic agonist; KB220 intravenous (IV) and oral variants, to improve dopaminergic function in SUD. Our pilot experiment found a significant reduction of chronic symptoms, measured by the Chronic Abstinence Symptom Severity (CASS) Scale. The combined group (IV and oral) did significantly better than the oral-only group over the first week and 30-day follow-up period...
November 2012: Journal of Psychoactive Drugs
Thomas J H Chen, Kenneth Blum, Amanda L C Chen, Abdalla Bowirrat, William B Downs, Margret A Madigan, Roger L Waite, John A Bailey, Mallory Kerner, Swetha Yeldandi, Neil Majmundar, John Giordano, Siohban Morse, David Miller, Frank Fornari, Eric R Braverman
This document presents evidence supporting the role of the KB220/KB220Z neuroadaptagens consisting of amino-acid neurotransmitter precursors and enkephalinase-catecholamine-methyl-transferase (COMT) inhibition therapy called Neuroadaptagen Amino Acid Therapy (NAAT) in brain reward function. It is becoming increasingly clear that this novel formulation is the first neuroadaptagen known to activate the brain reward circuitry. Ongoing research repeatedly confirms the numerous clinical effects that ultimately result in significant benefits for victims having genetic antecedents for all addictive, compulsive and impulsive behaviors...
April 2011: Journal of Psychoactive Drugs
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