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https://www.readbyqxmd.com/read/27904046/cocl2-decreases-ec-sod-expression-through-histone-deacetylation-in-cos7-cells
#1
Shuhei Hattori, Tetsuro Kamiya, Hirokazu Hara, Masayuki Ninomiya, Mamoru Koketsu, Tetsuo Adachi
Extracellular-superoxide dismutase (EC-SOD), one of the SOD isozymes, is negatively regulated under hypoxic conditions, and decreases in its expression may exacerbate vascular diseases. Moreover, epigenetics, such as DNA methylation and histone modifications, are known to play a critical role in the progression of cancer, type 2 diabetes, and atherosclerosis. We previously investigated the involvement of reactive oxygen species (ROS) and p38 mitogen-activated protein kinase (MAPK) in decreases in EC-SOD expression in hypoxic COS7 cells; however, the role of epigenetics in this process currently remains unknown...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27861245/selective-impairment-of-blood-pressure-reduction-by-endothelial-nitric-oxide-synthase-dimer-destabilization-in-mice
#2
Tatsiana Suvorava, Stephanie Pick, Georg Kojda
OBJECTIVES: Endothelial dysfunction and oxidative stress are associated with hypertension but whether endothelial superoxide may play a role in the early development of essential hypertension remains uncertain. We investigated whether endothelial nitric oxide synthase (eNOS)-derived endothelial oxidative stress is involved in the regulation of SBP. METHODS: Wild-type eNOS [mice with endothelium-specific overexpression of bovine endothelial NO-synthase (eNOS-Tg)] or a novel dimer-destabilized eNOS-mutant harboring a partially disrupted zinc-finger [mice with endothelium-specific overexpression of destabilized bovine eNOS destabilized by replacement of Cys 101 to Ala (C101A-eNOS-Tg)] was introduced in C57BL/6 in an endothelial-specific manner...
January 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27788262/resveratrol-reverses-functional-chagas-heart-disease-in-mice
#3
Glaucia Vilar-Pereira, Vitor C Carneiro, Hilton Mata-Santos, Amanda R R Vicentino, Isalira P Ramos, Naira L L Giarola, Daniel F Feijó, José R Meyer-Fernandes, Heitor A Paula-Neto, Emiliano Medei, Marcelo T Bozza, Joseli Lannes-Vieira, Claudia N Paiva
Chronic chagasic cardiomyopathy (CCC) develops years after acute infection by Trypanosoma cruzi and does not improve after trypanocidal therapy, despite reduction of parasite burden. During disease, the heart undergoes oxidative stress, a potential causative factor for arrhythmias and contractile dysfunction. Here we tested whether antioxidants/ cardioprotective drugs could improve cardiac function in established Chagas heart disease. We chose a model that resembles B1-B2 stage of human CCC, treated mice with resveratrol and performed electrocardiography and echocardiography studies...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27676031/phase-1b-trial-of-superoxide-so-dismutase-sod-mimetic-gc4419-to-reduce-chemoradiation-therapy-crt-induced-oral-mucositis-om-in-patients-pts-with-oral-cavity-or-oropharyngeal-carcinoma-occ
#4
C M Anderson, B G Allen, W Sun, S S Agarwala, C M Lee, M L Venigalla, L Greenberg, D Adkins, Y Chen, W Zhen, D R Mould, J Holmlund, J Brill, S T Sonis, J Buatti
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27649046/mntbap-inhibits-bleomycin-induced-pulmonary-fibrosis-by-regulating-vegf-and-wnt-signaling
#5
Rajkumar Venkatadri, Anand Krishnan V Iyer, Vani Ramesh, Clayton Wright, Carlos A Castro, Juan S Yakisich, Neelam Azad
Cellular oxidative stress is implicated not only in lung injury but also in contributing to the development of pulmonary fibrosis. We demonstrate that a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger, manganese (III) tetrakis (4-benzoic acid) porphyrin chloride (MnTBAP) significantly inhibited bleomycin-induced fibrogenic effects both in vitro and in vivo. Further investigation into the underlying mechanisms revealed that MnTBAP targets canonical Wnt and non-canonical Wnt/Ca2+ signaling pathways, both of which were upregulated by bleomycin treatment...
September 20, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27371912/synthesis-characterization-and-pharmacological-studies-of-copper-complexes-of-flavone-derivatives-as-potential-anti-tuberculosis-agents
#6
J Joseph, K Nagashri, A Suman
Novel series of different hydroxyflavone derivatives and their copper complexes were synthesized. They were characterized using analytical and spectral techniques. The superoxide dismutase (SOD) mimetic activity of the synthesized complexes demonstrated that copper complex of L(10) has promising SOD-mimetic activity than other ligands & complexes. The in vitro antimicrobial activities of the synthesized compounds were tested against the bacterial species and fungal species. The DNA binding properties of copper complexes were studied using cyclic voltametry and electronic absorption techniques...
September 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27343087/acquired-mitochondrial-abnormalities-including-epigenetic-inhibition-of-superoxide-dismutase-2-in-pulmonary-hypertension-and-cancer-therapeutic-implications
#7
Stephen L Archer
There is no cure for non-small-cell lung cancer (NSCLC) or pulmonary arterial hypertension (PAH). Therapies lack efficacy and/or are toxic, reflecting a failure to target disease abnormalities that are distinct from processes vital to normal cells. NSCLC and PAH share reversible mitochondrial-metabolic abnormalities which may offer selective therapeutic targets. The following mutually reinforcing, mitochondrial abnormalities favor proliferation, impair apoptosis, and are relatively restricted to PAH and cancer cells: (1) Epigenetic silencing of superoxide dismutase-2 (SOD2) by methylation of CpG islands creates a pseudohypoxic redox environment that causes normoxic activation of hypoxia inducible factor (HIF-1α)...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27325180/a-genetic-variation-of-sod2-does-not-determine-duration-of-response-to-androgen-deprivation-therapy-for-prostate-cancer
#8
Wanling Xie, Sarah Drouin, Mari Nakabayashi, Mark Pomerantz, Gwo-Shu Mary Lee, Philip W Kantoff, Nima Sharifi
BACKGROUND: Silencing SOD2 expression upregulates androgen receptor (AR) signaling and expression of SOD2 is downregulated in CRPC, compared with untreated tumors. The decreased SOD2 activity could lead to AR gain-of-function and the development of castration-resistance. METHODS: We genotyped SOD2-rs4880 in a cohort of 753 prostate cancer patients receiving androgen deprivation therapy (ADT) between 1996 and 2010. The rs4880 encodes Ala16Val in SOD2 and the Val variant has been demonstrated to be functionally less efficient than the Ala variant...
October 2016: Prostate
https://www.readbyqxmd.com/read/27303267/status-epilepticus-in-immature-rats-is-associated-with-oxidative-stress-and-mitochondrial-dysfunction
#9
Jaroslava Folbergrová, Pavel Ješina, Hana Kubová, Rastislav Druga, Jakub Otáhal
Epilepsy is a neurologic disorder, particularly frequent in infants and children where it can lead to serious consequences later in life. Oxidative stress and mitochondrial dysfunction are implicated in the pathogenesis of many neurological disorders including epilepsy in adults. However, their role in immature epileptic brain is unclear since there have been two contrary opinions: oxidative stress is age-dependent and does not occur in immature brain during status epilepticus (SE) and, on the other hand, evidence of oxidative stress in immature brain during a specific model of SE...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27294914/protective-effect-of-ginsenoside-rg1-on-hematopoietic-stem-progenitor-cells-through-attenuating-oxidative-stress-and-the-wnt-%C3%AE-catenin-signaling-pathway-in-a-mouse-model-of-d-galactose-induced-aging
#10
Jing Li, Dachuan Cai, Xin Yao, Yanyan Zhang, Linbo Chen, Pengwei Jing, Lu Wang, Yaping Wang
Stem cell senescence is an important and current hypothesis accounting for organismal aging, especially the hematopoietic stem cell (HSC). Ginsenoside Rg1 is the main active pharmaceutical ingredient of ginseng, which is a traditional Chinese medicine. This study explored the protective effect of ginsenoside Rg1 on Sca-1⁺ hematopoietic stem/progenitor cells (HSC/HPCs) in a mouse model of d-galactose-induced aging. The mimetic aging mouse model was induced by continuous injection of d-gal for 42 days, and the C57BL/6 mice were respectively treated with ginsenoside Rg1, Vitamin E or normal saline after 7 days of d-gal injection...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27262843/osteopontin-stimulated-apoptosis-in-cardiac-myocytes-involves-oxidative-stress-and-mitochondrial-death-pathway-role-of-a-pro-apoptotic-protein-bik
#11
Suman Dalal, Qinqin Zha, Mahipal Singh, Krishna Singh
Increased osteopontin (OPN) expression in the heart, specifically in myocytes, associates with increased myocyte apoptosis and myocardial dysfunction. Recently, we provided evidence that OPN interacts with CD44 receptor, and induces myocyte apoptosis via the involvement of endoplasmic reticulum stress and mitochondrial death pathways. Here we tested the hypothesis that OPN induces oxidative stress in myocytes and the heart via the involvement of mitochondria and NADPH oxidase-4 (NOX-4). Treatment of adult rat ventricular myocytes (ARVMs) with OPN (20 nM) increased oxidative stress as analyzed by protein carbonylation, and intracellular reactive oxygen species (ROS) levels as analyzed by ROS detection kit and dichlorohydrofluorescein diacetate staining...
July 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27256594/helium-based-cold-atmospheric-plasma-induced-reactive-oxygen-species-mediated-apoptotic-pathway-attenuated-by-platinum-nanoparticles
#12
Paras Jawaid, Mati Ur Rehman, Qing Li Zhao, Keigo Takeda, Kenji Ishikawa, Masaru Hori, Tadamichi Shimizu, Takashi Kondo
Plasma is generated by ionizing gas molecules. Helium (He)-based cold atmospheric plasma (CAP) was generated using a high-voltage power supply with low-frequency excitation (60 Hz at 7 kV) and He flow at 2 l/min. Platinum nanoparticles (Pt-NPs) are potent antioxidants due to their unique ability to scavenge superoxides and peroxides. These features make them useful for the protection against oxidative stress-associated pathologies. Here, the effects of Pt-NPs on He-CAP-induced apoptosis and the underlying mechanism were examined in human lymphoma U937 cells...
September 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27099261/sirt4-accelerates-ang-ii-induced-pathological-cardiac-hypertrophy-by-inhibiting-manganese-superoxide-dismutase-activity
#13
Yu-Xuan Luo, Xiaoqiang Tang, Xi-Zhou An, Xue-Min Xie, Xiao-Feng Chen, Xiang Zhao, De-Long Hao, Hou-Zao Chen, De-Pei Liu
AIMS: Oxidative stress contributes to the development of cardiac hypertrophy and heart failure. One of the mitochondrial sirtuins, Sirt4, is highly expressed in the heart, but its function remains unknown. The aim of the present study was to investigate the role of Sirt4 in the pathogenesis of pathological cardiac hypertrophy and the molecular mechanism by which Sirt4 regulates mitochondrial oxidative stress. METHODS AND RESULTS: Male C57BL/6 Sirt4 knockout mice, transgenic (Tg) mice exhibiting cardiac-specific overexpression of Sirt4 (Sirt4-Tg) and their respective controls were treated with angiotensin II (Ang II, 1...
April 20, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27069531/protective-effect-of-tempol-on-buthionine-sulfoximine-induced-mitochondrial-impairment-in-hippocampal-derived-ht22-cells
#14
Ankita Salvi, Gaurav Patki, Eisha Khan, Mohammad Asghar, Samina Salim
Using a simulated oxidative stress model of hippocampus-derived immortalized cell line (HT22), we report that prooxidant buthionine sulfoximine (BSO, 1 mM, 14 h), without adversely affecting cell viability or morphology, induced oxidative stress by inhibiting glutathione synthesis. BSO treatment also significantly reduced superoxide dismutase (SOD) activity (p < 0.05) and significantly lowered total antioxidant capacity (p < 0.001) in HT22 cells when compared to vehicle treated control cells. Antioxidant tempol, a piperidine nitroxide considered a SOD mimetic, reversed BSO-induced decline in SOD activity (p < 0...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27061200/attenuated-flow-induced-dilatation-of-middle-cerebral-arteries-is-related-to-increased-vascular-oxidative-stress-in-rats-on-a-short-term-high-salt-diet
#15
Anita Cosic, Ivana Jukic, Ana Stupin, Martina Mihalj, Zrinka Mihaljevic, Sanja Novak, Rosemary Vukovic, Ines Drenjancevic
KEY POINTS: Recent studies have shown that high salt (HS) intake leads to endothelial dysfunction and impaired vascular reactivity in different vascular beds in both animal and human models, due to increased oxidative stress. The objective of this study was to assess vascular response to flow-induced dilatation (FID) and to elucidate the role of vascular oxidative stress/antioxidative capacity in middle cerebral arteries (MCAs) of HS-fed rats in vitro. The novelty of this study is in demonstrating impaired flow-induced dilatation of MCAs and down-regulation of vascular antioxidant genes with HS intake, leading to increased levels of oxidative stress in blood vessels and peripheral lymph organs, which together contribute to impaired FID...
September 1, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/26970789/synthesis-structural-diversity-and-mimic-superoxide-dismutase-of-mn-ii-complexes-derived-from-n-o-donor-schiff-bases
#16
Jie Qin, Qiang Yin, Shan-Shan Zhao, Jun-Zheng Wang, Shao-Song Qian
Two new potentially tetradentate Schiff base ligands N'-(pyridin-2-ylmethylene)nicotinohydrazide (L1), and N'-(pyridin-2-ylmethylene)isonicotinohydrazide (L(2)) were synthesized. Reactions of hydrazone ligands L(1) and L(2) with Mn(NO(3))(2) afford two mononuclear Mn(II) complexes, [Mn(L(1))(NO(3))(H(2)O)(2)]•(NO(3)) (1) and [Mn(L(2))(2)(NO(3))(H(2)O)]•(NO(3)) (2). For complexes 1 and 2, L(1) and L(2) act as pincer-like tridentate or bidentate ligands, respectively. The Mn(II) ions in the two compounds are both in heptacoordinated environment, while the two molecules display diverse solid-state supramolecular structures because of the different orientation of Npyridine and hydrogen bonding patterns of nitrate anions...
2016: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/26964942/effect-of-platinum-nanoparticles-on-cell-death-induced-by-ultrasound-in-human-lymphoma-u937-cells
#17
Paras Jawaid, Mati Ur Rehman, Mariame Ali Hassan, Qing Li Zhao, Peng Li, Yusei Miyamoto, Masaki Misawa, Ryohei Ogawa, Tadamichi Shimizu, Takashi Kondo
In this study, we report on the potential use of platinum nanoparticles (Pt-NPs), a superoxide dismutase (SOD)/catalase mimetic antioxidant, in combination with 1MHz ultrasound (US) at an intensity of 0.4 W/cm(2), 10% duty factor, 100 Hz PRF, for 2 min. Apoptosis induction was assessed by DNA fragmentation assay, cell cycle analysis and Annexin V-FITC/PI staining. Cell killing was confirmed by cell counting and microscopic examination. The mitochondrial and Ca(2+)-dependent pathways were investigated. Caspase-8 expression and autophagy-related proteins were detected by spectrophotometry and western blot analysis, respectively...
July 2016: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/26953346/superoxide-dismutase-sod-mimetic-m40403-is-protective-in-cell-and-fly-models-of-paraquat-toxicity-implications-for-parkinson-disease
#18
Roberta Filograna, Vinay K Godena, Alvaro Sanchez-Martinez, Emanuele Ferrari, Luigi Casella, Mariano Beltramini, Luigi Bubacco, Alexander J Whitworth, Marco Bisaglia
Parkinson disease is a debilitating and incurable neurodegenerative disorder affecting ∼1-2% of people over 65 years of age. Oxidative damage is considered to play a central role in the progression of Parkinson disease and strong evidence links chronic exposure to the pesticide paraquat with the incidence of the disease, most probably through the generation of oxidative damage. In this work, we demonstrated in human SH-SY5Y neuroblastoma cells the beneficial role of superoxide dismutase (SOD) enzymes against paraquat-induced toxicity, as well as the therapeutic potential of the SOD-mimetic compound M40403...
April 22, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26918394/prussian-blue-nanoparticles-as-multienzyme-mimetics-and-reactive-oxygen-species-scavengers
#19
Wei Zhang, Sunling Hu, Jun-Jie Yin, Weiwei He, Wei Lu, Ming Ma, Ning Gu, Yu Zhang
The generation of reactive oxygen species (ROS) is an important mechanism of nanomaterial toxicity. We found that Prussian blue nanoparticles (PBNPs) can effectively scavenge ROS via multienzyme-like activity including peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) activity. Instead of producing hydroxyl radicals (•OH) through the Fenton reaction, PBNPs were shown to be POD mimetics that can inhibit •OH generation. We theorized for the first time that the multienzyme-like activities of PBNPs were likely caused by the abundant redox potentials of their different forms, making them efficient electron transporters...
May 11, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/26916739/bioinspired-superoxide-dismutase-mimics-the-effects-of-functionalization-with-cationic-polyarginine-peptides
#20
H Y Vincent Ching, Isabell Kenkel, Nicolas Delsuc, Emilie Mathieu, Ivana Ivanović-Burmazović, Clotilde Policar
Continuing a bio-mimetic approach, we have prepared peptide conjugates of a superoxide dismutase (SOD) mimic [MnL](+) (where HL=N-(2-hydroxybenzyl)-N,N'-bis[2-(N-methylimidazolyl)methyl]ethane-1,2-diamine), namely [MnL'-Arg(n-1)](n+) (where n=2, 4, 7 and 10) and [MnL'-Gly1](+). [MnL'-Arg(n-1)](n+) contained cationic residue(s) that emulate the electrostatic channel of the enzyme. Physicochemical methods showed that functionalization at the secondary amine of HL did not impair coordination to Mn(II) with association constants (Kassoc) between 1...
July 2016: Journal of Inorganic Biochemistry
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