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https://www.readbyqxmd.com/read/29344915/mechanistic-investigation-of-visible-light-driven-photocatalytic-inactivation-of-e-coli-by-ag-agcl-znfe2o4
#1
Akhanda Raj Upreti, Nirina Khadgi, Yi Li
In this study, photocatalytic inactivation of Escherichia coli was investigated over magnetic nanocomposite Ag-AgCl/ZnFe2O4. The nanocomposite demonstrated efficient photocatalytic activity by complete inactivation of the bacteria within 60 min of visible light irradiation. The anions HPO42- and SO42- were found to play the most important role in the inhibition of photocatalytic inactivation of E. coli. A systematic investigation of mechanism of photocatalytic bacterial inactivation was carried out based on cell membrane injury test, scanning electron microscopy (SEM) of bacterial morphology changes, Fourier transform infrared (FTIR) spectroscopy of E...
January 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29344650/adrenomedullin-serves-a-role-in-the-humoral-pathway-of-delayed-remote-ischemic-preconditioning-via-a-hypoxia-inducible-factor-1%C3%AE-associated-mechanism
#2
Wenpei Dong, Ping Yu, Tielong Zhang, Chenzhuang Zhu, Jun Qi, Junhao Liang
Remote ischemic preconditioning (RIPC) is a minimally invasive method that provides protection by reducing injury to the heart, kidneys, brain and other tissues or organs. RIPC may improve the outcome in patients undergoing surgery. Although the role of RIPC has been studied, the results remain controversial. It is difficult to confirm whether RIPC has a kidney protective effect and the understanding of the preconditioning signal pathway involved remains unclear. In the present study, the effect of RIPC in urology was evaluated...
January 17, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29344209/the-effect-of-royal-jelly-on-the-growth-of-breast-cancer-in-mice
#3
Shuang Zhang, Qiqi Shao, Haiyang Geng, Songkun Su
Due to various pharmacological properties, including antioxidative, anti-inflammatory and antibiotic properties, royal jelly (RJ) has been widely consumed in daily diets in numerous countries. In the present study, the effect of RJ on 4T1-bearing mice was investigated. The study was performed by feeding 4T1-bearing mice with RJ using either the prophylactic-therapeutic (PTRJ) or therapeutic (TRJ) method. The experimental results for the PTRJ group demonstrated that the weight of tumor was significantly reduced (RJ 0...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343446/s-adenosyl-methionine-prevents-asd-like-behaviors-triggered-by-early-postnatal-valproic-acid-exposure-in-very-young-mice
#4
Asher Ornoy, Liza Weinstein-Fudim, Matanel Tfilin, Zivanit Ergaz, Joseph Yanai, Moshe Szyf, Gadi Turgeman
INTRODUCTION: A common animal model of ASD is the one induced by valproic acid (VPA), inducing epigenetic changes and oxidative stress. We studied the possible preventive effect of the methyl donor for epigenetic enzymatic reactions, S-adenosine methionine (SAM), on ASD like behavioral changes and on redox potential in the brain and liver in this model. METHODS: ICR albino mice were injected on postnatal day 4 with one dose of 300 mg/kg of VPA, with normal saline (controls) or with VPA and SAM that was given orally for 3 days at the dose of 30 mg/kg body weight...
January 14, 2018: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29343259/influence-of-apocynin-on-cardiac-remodeling-in-rats-with-streptozotocin-induced-diabetes-mellitus
#5
R Gimenes, C Gimenes, C M Rosa, N P Xavier, D H S Campos, A A H Fernandes, M D M Cezar, G N Guirado, L U Pagan, I D Chaer, D C Fernandes, F R Laurindo, A C Cicogna, M P Okoshi, K Okoshi
BACKGROUND: Increased reactive oxygen species (ROS) generation in diabetes mellitus (DM) is an important mechanism leading to diabetic cardiomyopathy. Apocynin, a drug isolated from the herb Picrorhiza kurroa, is considered an antioxidant agent by inhibiting NADPH oxidase activity and improving ROS scavenging. This study analyzed the influence of apocynin on cardiac remodeling in diabetic rats. METHODS: Six-month-old male Wistar rats were assigned into 4 groups: control (CTL, n = 15), control + apocynin (CTL + APO, n = 20), diabetes (DM, n = 20), and diabetes + apocynin (DM + APO, n = 20)...
January 17, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29343256/the-effects-of-green-cardamom-supplementation-on-blood-glucose-lipids-profile-oxidative-stress-sirtuin-1-and-irisin-in-type-2-diabetic-patients-a-study-protocol-for-a-randomized-placebo-controlled-clinical-trial
#6
Mohadeseh Aghasi, Shohreh Ghazi-Zahedi, Fariba Koohdani, Fereydoun Siassi, Ensieh Nasli-Esfahani, Ali Keshavarz, Mostafa Qorbani, Hoorieh Khoshamal, Asma Salari-Moghaddam, Gity Sotoudeh
BACKGROUND: It has been suggested that the antioxidant, anti-inflammatory and hypolipidemic activities of cardamom may improve diabetes. However, the effect of this spice has not been investigated in diabetic subjects. This study was planned to determine the effects of green cardamom on blood glucose, lipids and oxidative stress status in type 2 diabetic patients. METHODS/DESIGN: Eighty overweight or obese patients with type 2 diabetes will be selected. They will be randomly assigned to receive 3 g/d green cardamom or placebo for 10 weeks...
January 17, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29343081/atorvastatin-reduces-plasma-inflammatory-and-oxidant-biomarkers-in-patients-with-risk-of-atherosclerotic-cardiovascular-disease
#7
Fadia Mayyas, Duha Baydoun, Rasheed Ibdah, Khalid Ibrahim
BACKGROUND: Oxidative stress and inflammation are associated with endothelial injury and coronary artery disease. Inflammatory factors that promote oxidative damage include endothelin-1 (ET-1), myeloperoxidase (MPO), and C-reactive protein (CRP). Current guidelines recommend the use of statins in patients with risk of atherosclerotic cardiovascular disease (ASCVD). AIM: To assess the impact of atorvastatin on plasma inflammatory and oxidant biomarkers in patients with moderate to very high risk of ASCVD...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29342974/trypsin-binding-with-copper-ions-scavenges-superoxide-molecular-dynamics-based-mechanism-investigation
#8
Xin Li, Yongliang Zhong, Chunyan Zhao
Trypsin is a serine protease, which has been proved to be a novel superoxide scavenger. The burst of superoxide induced by polychlorinated biphenyls can be impeded by trypsin in both wild type and sod knockout mutants of Escherichia coli. The experimental results demonstrated that the activities of superoxide scavenging of trypsin were significantly accelerated by Cu ions. Also, with the addition of Cu ions, a new β-sheet (β7) transited from a random coil in the Cu(II)-trypsin (TP) system, which was favorable for the formation of more contacts with other sheets of trypsin...
January 15, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29341310/critical-appraisal-of-the-oxidative-stress-pathway-in-vitiligo-a-systematic-review-and-meta-analysis
#9
REVIEW
R Speeckaert, J Dugardin, J Lambert, H Lapeere, E Verhaeghe, M M Speeckaert, N van Geel
BACKGROUND: The pathogenesis of vitiligo remains a topic of extensive debate. This is partly due to the moderate efficacy of current treatments. The role of oxidative stress pathway in vitiligo is a popular although controversial research topic. OBJECTIVE: To clarify the role of the oxidative stress pathway in vitiligo compared to other inflammatory skin disorders and to assess the therapeutic role of antioxidants. METHODS: We conducted a systematic search of the existing literature on the aberrancies of the oxidative stress pathway in vitiligo...
January 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29339975/genetic-polymorphisms-of-antioxidant-enzymes-cat-and-sod-affect-the-outcome-of-clinical-biochemical-and-anthropometric-variables-in-people-with-obesity-under-a-dietary-intervention
#10
César Hernández-Guerrero, Alicia Parra-Carriedo, Diana Ruiz-de-Santiago, Oscar Galicia-Castillo, Mario Buenrostro-Jáuregui, Carmen Díaz-Gutiérrez
Background: Genetic polymorphisms of antioxidant enzymes CAT, GPX, and SOD are involved in the etiology of obesity and its principal comorbidities. The aim of the present study was to analyze the effect of aforementioned SNPs over the output of several variables in people with obesity after a nutritional intervention. The study included 92 Mexican women, which received a dietary intervention by 3 months. Participants were genotyped and stratified into two groups: (1) carriers; mutated homozygous plus heterozygous (CR) and (2) homozygous wild type (WT)...
2018: Genes & Nutrition
https://www.readbyqxmd.com/read/29339254/design-synthesis-biological-evaluation-and-docking-studies-of-new-3-4-5-dihydro-1h-pyrazol-isoxazol-5-yl-2-phenyl-1h-indole-derivatives-as-potent-antioxidants-and-15-lipoxygenase-inhibitors
#11
Haydi Saher ElBordiny, Mostafa Mahmoud El-Miligy, Shaymaa Emam Kassab, Hoda Daabees, Soad Abdelhamid Mohamed El-Hawash, Waleed Ali Mohamed Ali
New candidates of 3-(4,5-dihydro-1H-pyrazol/isoxazol-5-yl)-2-phenyl-1H-indole derivatives (4-7) were designed combining the pyrazoline/isoxazoline heterocycles and 2-phenylindole to explore its potential as 15-lipoxygenase (15-LOX) inhibitors. The design of the new derivatives was based on utilizing the antioxidant properties of pyrazoline, 2-phenylindole and the good 15-LOX inhibition properties of indolylpyrazoline. The derivatives were synthesized adopting simple and laboratory friendly reaction conditions to give the target compounds in quantitative yields...
January 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29339218/protective-effect-of-patchoulene-epoxide-against-ethanol-induced-gastric-ulcer-in-rats-influence-on-oxidative-stress-inflammation-and-apoptosis
#12
Jiali Liang, Yaoxing Dou, Xue Wu, Huilin Li, Jiazhen Wu, Qionghui Huang, Dandan Luo, Tiegang Yi, Yuhong Liu, Ziren Su, Jianping Chen
Patchoulene epoxide (PAO), a tricyclic sesquiterpene isolated from the long-strored patchouli oil, has been demonstrated the anti-inflammatory activity in vivo based on our previous study. However, the gastroprotective effect of PAO still remains unknown. Therefore, in the present study, ethanol-induced gastric ulcer in rats was carried out to evaluate the anti-ulcerogenic activity of PAO and to elucidate the potential mechanisms that involved. According to our results, macroscopic examination revealed that pre-treatment with PAO signficantly reduced ethanol-induced gastric ulcer areas as compared with the vehicle group, which was also supported by histological evaluation...
January 12, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29339102/spirulina-ameliorates-methotrexate-hepatotoxicity-via-antioxidant-immune-stimulation-and-proinflammatory-cytokines-and-apoptotic-proteins-modulation
#13
Asmaa F Khafaga, Yasser S El-Sayed
AIMS: Methotrexate (MTX) is an efficient cytotoxic drug used against various carcinogenic, inflammatory and autoimmune diseases; however, the hepatotoxicity of MTX limits its use. Therefore, the present study aimed to evaluate the potential hepatoprotective and immune-stimulant effect of Spirulina platensis (SP) against MTX acute toxicity. MAIN METHODS: Thirty-two male Wistar rats were randomly allocated into the following four groups (n = 8): control, MTX (20 mg/kg bwt, single ip injection), SP (500 mg/kg bwt, oral gavage daily for 21 days), and MTX+SP...
January 12, 2018: Life Sciences
https://www.readbyqxmd.com/read/29337369/hepatoprotective-effects-of-the-honey-of-apis-cerana-fabricius-on-bromobenzene-induced-liver-damage-in-mice
#14
Haoan Zhao, Ni Cheng, Liangliang He, Guoxia Peng, Qingqing Liu, Tianchen Ma, Wei Cao
Apis cerana honey (honey of Apis cerana Fabricius), widely distributed in the mountain areas of East Asia, has not been studied fully. The hepatoprotective activity of A. cerana honey was evaluated against bromobenzene-induced liver damage in mice. In high dose, A. cerana honey can significantly alleviate liver injury, as is indicated by the depressed levels of serum alanine aminotransferase (ALT) (59.13%) and aspartate aminotransferase (AST) (79.71%), the inhibited malondialdehyde (MDA) content (63.30%), the elevated activities of superoxide dismutase (SOD) (73...
January 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29337229/protective-effect-of-flavonoids-from-cyclocarya-paliurus-leaves-against-carbon-tetrachloride-induced-acute-liver-injury-in-mice
#15
Jianhua Xie, Wenjie Wang, Caijun Dong, Lixin Huang, Hui Wang, Chang Li, Shaoping Nie, Mingyong Xie
Cyclocarya paliurus (Batal.) Iljinskaja (C. paliurus), known locally as 'sweet tea tree', is commonly cultivated in China. Flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja (FC) is reported to exhibit multiple biological effects, including anti-inflammatory, anti-oxidant and anti-diabetic activities. However, their influence on carbon tetrachloride (CCl4)-induced acute liver injury remains unclear. This study was designed to investigate the hepatoprotective effect of total flavonoids from C. paliurus leaves...
January 11, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29337195/secretoneurin-suppresses-cardiac-hypertrophy-through-suppression-of-oxidant-stress
#16
Hua-Li Chen, Yan Liu, Wei Jiang, Xiao-Xiao Wang, Guo-Lin Yuan, Yi-Lin Zhao, Chao Yu
The neuropeptide secretoneurin (SN) plays protective roles in myocardial ischemia. In the present study, the effect of SN in cardiac hypertrophy was investigated. We observed that, in isoproterenol (ISO) treatment induced cardiac or cardiomyocytes hypertrophy, a marked increase in the expression of endogenous SN in mouse plasma, myocardium and primary-cultured cardiomyocytes occurs. In hypertrophic mice, the heart size, heart weight/body weight (HW/BW) ratio, cardiomyocyte size, and atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) expression were significantly higher than those in controls but were effectively suppressed by SN gene therapy...
January 11, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29334806/effect-of-scuba-diving-on-the-oxidant-antioxidant-status-sirt1-and-sirt3-expression-in-recreational-divers-after-a-winter-nondive-period
#17
Antonija Perović, Sandra Sobočanec, Sanja Dabelić, Tihomir Balog, Jerka Dumić
The aim of this study was to examine the effects of scuba diving on oxidative damage markers in erythrocytes and plasma, antioxidant system in peripheral blood mononuclear cells (PBMCs), as well as sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3) gene expressions in recreational divers after a winter nondive period (at least 5 months). For that purpose, 17 male recreational divers performed an immersion at a depth of 30 m for 30 min. Blood samples were collected immediately before and after diving, 3 and 6 h after diving...
January 15, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29334762/altered-redox-state-modulates-endothelial-kca2-3-and-kca3-1-levels-in-normal-pregnancy-and-preeclampsia
#18
Shinkyu Choi, Ji Aee Kim, Hai-Yan Li, Sae-Jin Lee, Ye Seon Seok, Tae Hun Kim, Ki-Hwan Han, Mi Hye Park, Geum Joon Cho, Suk Hyo Suh
AIMS: Altered redox state has been related to the development of normal pregnancy (NP) and preeclampsia (PE). Endothelial KCa2.3 and KCa3.1 (KCas) play an important role in vasodilation, and KCas levels are affected by oxidative stress. We investigated the mechanisms of oxidative stress-mediated KCas expression modulation during NP and PE. RESULTS: Human uterine microvascular endothelial cells were incubated in serum from normal non-pregnant women (n=13) and women with NP (n=24) or PE (n=15), or in VEGF, oxidized low-density lipoprotein (ox-LDL), progesterone, or estradiol-17-containing medium for 24 hours...
January 15, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29334666/effects-of-berberine-chloride-on-the-liver-of-streptozotocin-induced-diabetes-in-albino-wistar-rats
#19
Govindasami Chandirasegaran, Chakkaravarthy Elanchezhiyan, Kavisa Ghosh
The goal of the present study is to evaluate the effect of Berberine chloride (BC) on the liver of streptozotocin (STZ) induced diabetic rat. Diabetic rats were treated with BC (50 mg/kg b.w) or glibenclamide (6 mg/kg b.w), daily for 45 days. After BC treatment in diabetic rats, there was a significant (P < 0.05) decline in the levels of hepatic markers, lipid peroxidation markers such as lipid hydroperoxides (LOOH) and thiobarbituric acid reactive substances (TBARS), and pro-inflammatory mediators like tumor necrosis factor-alpha (TNF-α), phosphorylated nuclear factor kappa-B-p65 (phospho-NF-κB p65), cyclooxygenase (COX-2), nitric oxide synthase (iNOS) as well as pro-apoptotic mediators such as Bax and cytochrome c...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29334419/a-metallo-pro-drug-to-target-cu-ii-in-the-context-of-alzheimer-s-disease
#20
Amandine Conte-Daban, Vinita Ambike, Régis Guillot, Nicolas Delsuc, Clotilde Policar, Christelle Hureau
Alzheimer's disease and oxidative stress are connected. In the present communication, we report the use of a Mn(II)-based superoxide dismutase mimic ([MnII(L)]+, 1+) as a pro-drug candidate to target Cu(II) associated events, i.e. Cu(II)-induced formation of reactive oxygen species (ROS) and modulation of the amyloid-beta (Abeta) peptide aggregation. Complex 1+ is able to remove Cu(II) from Abeta, stop ROS and prevent alteration of Abeta aggregation as would do the corresponding free ligand LH. Using 1+ instead of LH in further biological applications would have the double advantage to avoid the cell toxicity of LH and to benefit from its proved SOD-like activity...
January 15, 2018: Chemistry: a European Journal
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