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https://www.readbyqxmd.com/read/28938514/-2-4-fluorobenzamido-4-methylthiazole-5-carboxylic-acid-a-novel-thiazole-compound-ameliorates-insulin-sensitivity-and-hyperlipidaemia-in-streptozotocin-induced-diabetic-rats-plausible-role-of-inflammatory-and-oxidative-stress-markers
#1
Yam Nath Paudel, Md Rahmat Ali, Mohammad Adil, Sandhya Bawa, Manju Sharma
Emerging evidence suggests that thiazole compounds are of great interest due to their protective effect against DM. Protective effects of thiazole derivatives against hyperglycemia have been demonstrated in earlier in vitro and in vivo studies. Previously, anti-oxidant and free radical scavenging activities of 2-(4-Fluorobenzamido)-4-methylthiazole-5-carboxylicacid, a newly developed thiazole derivative (NDTD), have been well-documented. Current study investigated the pharmacological effect of NDTD on hyperglycaemia, insulin sensitivity, lipid profile, anti-inflammatory and oxidative stress markers in an animal model...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28938148/intestinal-epithelial-cell-injury-induced-by-copper-containing-nanoparticles-in-piglets
#2
Hui Zhang, Xiaoxing Wu, Khalid Mehmood, Zhenyu Chang, Kun Li, Xiong Jiang, Fazul Nabi, Muhammad Ijaz, Mujeeb Ur Rehman, Muhammad Tariq Javed, Donghai Zhou
The nano copper has been widely used in modern clinical medicine practice. However, it has been noticed that nano copper particles induce cell injury and toxicity. The present study was designed to determine the effect of nano copper particles on cell injury of intestinal epithelial cells (IECs) in piglets. The IECs were treated with different doses of nano copper (5, 10, 20 and 40μg/ml) for 24-48h to observe cell injury and toxicity. Cell injury was measured based on morphological and other changes including oxidative stress and genes expression...
September 18, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28937746/-juice-monsters-sub-ohm-vaping-and-toxic-volatile-aldehyde-emissions
#3
Soha Talih, Rola Salman, Nareg Karaoghlanian, Ahmad El-Hellani, Najat Aoun Saliba, Thomas Eissenberg, Alan Shihadeh
An emerging category of electronic cigarettes (ECIGs) are sub-Ohm devices (SODs) that operate at ten or more times the power of conventional ECIGs. Because carcinogenic volatile aldehyde (VAs) emissions increase sharply with power, SODs may expose users to greater VAs. In this study, we compared VA emissions from several SODs and found that across device, VAs and power were un-correlated unless power was normalized by coil surface area. VA emissions and liquid consumed were correlated highly. Analyzed in light of EU regulations limiting ECIG liquid nicotine concentration, these findings suggest potential regulatory levers and pitfalls for protecting public health...
September 22, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28937261/radiation-induced-bystander-effect-in-the-spleen-of-cranially-irradiated-rats
#4
Amal A Mohye El-Din, Abdelrazek Bedeer Abdelrazzak, Moustafa Tawfik Ahmed, Mohamed A El-Missiry
OBJECTIVE: To investigate the radiation induced abscopal effect in terms of oxidative stress, apoptosis and DNA damage in the spleen cells following cranial X-rays irradiation of rats. METHODS: Rats were cranially irradiated using 2 Gy X-rays. Another group was whole-body irradiated with 2 Gy X-rays and a third group was exposed to scattered radiation (measured to be 3 mGy). Twenty four hours following irradiation, sections from the spleen of the rats were dissected as well as plasma samples...
September 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28937043/inhibition-of-cd38-cyclic-adp-ribose-pathway-protects-rats-against-ropivacaine-induced-convulsion
#5
Yu Zou, Xin He, Qian-Yi Peng, Qu-Lian Guo
BACKGROUND: The CD38/cyclic ADP-ribose (cADPR) pathway plays a role in various central nervous system diseases and in morphine tolerance, but its role in local anesthetic intoxication is unknown. The aim of this study was to determine the role of the CD38/cADPR pathway in ropivacaine-induced convulsion. METHODS: Forty male Sprague-Dawley rats were randomly divided into five groups (n = 8 per group): sham group, ropivacaine group, ropivacaine+8-Br-cADPR (5 nmol) group, ropivacaine+8-Br-cADPR (10 nmol) group, and ropivacaine+8-Br-cADPR (20 nmol) group (no rats died)...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936571/effect-of-dietary-astaxanthin-on-the-growth-performance-non-specific-immunity-and-antioxidant-capacity-of-pufferfish-takifugu-obscurus-under-high-temperature-stress
#6
Chang-Hong Cheng, Zhi-Xun Guo, Chao-Xia Ye, An-Li Wang
The present study was conducted to investigate the effects of astaxanthin on growth performance, biochemical parameters, ROS production, and immune-related gene expressions of the pufferfish (Takifugu obscurus) under high temperature stress. The experimental basal diets supplemented with astaxanthin at the rates of 0 (control), 20, 40, 80, 160, and 320 mg kg(-1) were fed to fish for 8 weeks. The results showed that the fish fed diet with 80, 160, and 320 mg kg(-1) astaxanthin significantly improved weight gain and specific growth rate...
September 21, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28936278/modulating-the-catalytic-activity-of-cerium-oxide-nanoparticles-with-the-anion-of-the-precursor-salt
#7
Swetha Barkam, Julian Ortiz, Shashank Saraf, Nicholas Eliason, Rameech Mccormack, Soumen Das, Ankur Gupta, Craig Neal, Alex Petrovici, Cameron Hanson, Michael D Sevilla, Amitava Adhikary, Sudipta Seal
In this work, we tested our hypothesis that surface chemistry and antioxidant properties of cerium nanoparticles (CNPs) are affected by presence of counterions. We first employed various precursor cerium (III) (Ce(III)) salts with different counterions (acetate, nitrate, chloride, sulfate) to synthesize CNPs following the same wet chemical methodology. Electron spin resonance (ESR) studies provided evidence for the formation of radicals from counterions (e.g., NO3•(2-) from reduction of NO3(-) in CNPs synthesized from Ce(III) nitrate)...
September 14, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28935951/overexpression-of-annexin-gene-annsp2-enhances-drought-and-salt-tolerance-through-modulation-of-aba-synthesis-and-scavenging-ros-in-tomato
#8
Raina Ijaz, Javeria Ejaz, Shenghua Gao, Tengfei Liu, Muhammad Imtiaz, Zhibiao Ye, Taotao Wang
Drought and high salinity are two major abiotic stresses that significantly affect agricultural crop productivity worldwide. Annexins are a multigene family that plays an essential role in plant stress responses and various cellular processes. Here, the AnnSp2 gene was cloned from drought-resistant wild tomato (Solanum pennellii) and functionally characterized in cultivated tomato. AnnSp2 protein was localized in the nucleus and had higher expression in leave, flower and fruit. It was induced by several phytohormones and some abiotic stresses...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28934804/comparison-of-7-surgical-interventions-for-lumbar-disc-herniation-a-network-meta-analysis
#9
Fan Feng, Qianqian Xu, Feifei Yan, Yuanlong Xie, Zhouming Deng, Chao Hu, Xiaobin Zhu, Lin Cai
BACKGROUND: The number of interventions on intervertebral discs rapidly increased and the treatment options for lumbar disc surgery quickly evolved. It is important that the safety and efficacy of all new innovative procedures be compared with currently accepted forms of treatment; however, the previous pairwise meta-analyses could not develop the hierarchy of these treatments. OBJECTIVES: The purpose of the study is to perform a network meta-analysis to evaluate the clinical results of 7 surgical interventions for the treatment of lumbar disc herniation...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934742/elevated-apoptosis-in-the-liver-of-dairy-cows-with-ketosis
#10
Xiliang Du, Liang Chen, Dan Huang, Zhicheng Peng, Chenxu Zhao, Yuming Zhang, Yiwei Zhu, Zhe Wang, Xinwei Li, Guowen Liu
BACKGROUND/AIMS: Dairy cows with ketosis are characterized by oxidative stress and hepatic damage. The aim of this study was to investigate hepatic oxidative stress and the apoptotic status of ketotic cows, as well as the underlying apoptosis pathway. METHODS: The blood aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamate dehydrogenase (GLDH) and gamma-glutamyl transferase (GGT) activities and the haptoglobin (HP), serum amyloid A (SAA) and serum apoptotic cytokeratin 18 neo-epitope M30 (CK18 M30) concentrations were determined by commercially available kits and ELISA kits, respectively...
September 21, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28934710/calcium-availability-but-not-its-content-modulates-metal-toxicity-in-scenedesmus-quadricauda
#11
Jozef Kováčik, Sławomir Dresler
Impact of calcium nutrition (pre-culture on solid medium with standard or elevated Ca dose, i. e. 0.17 and 4.40mM marked as low and high Ca) on acute metal toxicity (Cd, Mn and Pb, 24h of exposure to 10µM) in freshwater green alga Scenedesmus quadricauda was studied. Surprisingly, Ca content differed only slightly between low and high Ca samples and applied metals rather suppressed its amount. Na content was higher in metal-exposed high Ca samples, indicating that Ca/Na ratio may affect accumulation of metals...
September 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28934659/comparison-on-the-effects-of-water-borne-and-dietary-borne-accumulated-zno-nanoparticles-on-daphnia-magna
#12
Yanjiao Chen, Fengxia Wu, Wenying Li, Tiangang Luan, Li Lin
Nanoparticles (NPs) can exert toxicity to aquatic animals through water and dietary exposure. However, little is known about the contribution of the two exposure pathways to the total toxicity of NPs to aquatic animals. In the present study, we fed Daphnia magna with ZnO NPs-accumulated-algae or directly exposed them to ZnO NPs suspension at the same Zn concentration. The body Zn concentrations were the same in both treatments, but the surface elastic modulus in the water-borne group was lower than that in the dietary-borne group, indicating more severe surface damage in the water-borne treatment...
August 25, 2017: Chemosphere
https://www.readbyqxmd.com/read/28934643/combined-effects-of-microcystin-and-nitrite-on-the-growth-lipid-peroxidation-and-antioxidant-responses-of-the-freshwater-rotifer-brachionus-calyciflorus
#13
Ye Liang, Xinglan Chen, Xuxin Lu, Sichen Jin, Yuanqi Min, Jiaxin Yang
Toxicants released during the degradation of cyanobacterial blooms, such as microcystin-LR (MC-LR) and nitrite (NO2-N), affect the growth of aquatic organisms. The freshwater rotifer Brachionus calyciflorus was exposed to solutions with different combined concentrations of MC-LR (0, 10, 50, 100, and 200μgL(-1)) and NO2-N (0, 2, 4, 6, and 8mgL(-1)) to assess the combined effects of MC-LR and NO2-N on life cycle parameters and oxidative stress. Single solutions of MC-LR 200μgL(-1) and NO2-N 8mgL(-1) were toxic to rotifers...
September 14, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28933499/multi-biomarker-approach-in-the-scallop-chlamys-farreri-to-assess-pahs-pollution-in-qingdao-coastal-areas-of-china
#14
Luqing Pan, Mengyu Zhang, Qian Jin, Rongwang Ji
A multi-biomarker approach was conducted in the scallop Chlamys farreri from three sites, denoted here as S1, S2, and S3, in Qingdao coastal areas of China in March, June, September and December 2014 to assess pollution from polycyclic aromatic hydrocarbons (PAHs) and to select appropriate biomarkers. A suite of biological responses of the gills and digestive glands of the scallops was assayed, including: (i) phase I detoxification enzymes of 7-ethoxyresorufin-O-deethylase (EROD), epoxide hydrolase (EH), and dihydrodiol dehydrogenase (DD) and phase II detoxification enzymes of glutathione-S-transferase (GST) and sulfotransferase (SULT); (ii) antioxidant enzymes: catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx); (iii) oxidative damage parameters: lipid peroxidation (LPO) expressed by malondialdehyde (MDA) contents, protein carbonylation (PC) and DNA damage (F value); and (iv) the metabolism-related genes of EH, DD, GST, SULT and SOD...
September 21, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28933492/the-hepatoprotective-effect-of-the-probiotic-clostridium-butyricum-against-carbon-tetrachloride-induced-acute-liver-damage-in-mice
#15
Jiaming Liu, Yaoyang Fu, Hao Zhang, Jindan Wang, Jing Zhu, Yaqi Wang, Yuegui Guo, Guocan Wang, Tianqi Xu, Maoping Chu, Fangyan Wang
Previous studies have revealed that the probiotic Clostridium butyricum (C. butyricum) can attenuate cirrhosis in chronic non-alcoholic liver disease. However, the effects of C. butyricum on acute liver injury (ALI) remain unclear. Therefore, the present study aims to examine the hepatoprotective effects and the underlying mechanisms employed by C. butyricum in a carbon tetrachloride (CCl4)-induced ALI murine model. Here, we evaluated the survival rate and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), anti-oxidants, cytokines and the gut microbiota to elucidate the potential mechanisms by which C...
September 21, 2017: Food & Function
https://www.readbyqxmd.com/read/28933094/-protective-effects-of-luteolin-against-acetaminophen-induced-damage-in-l02-liver-cells
#16
Lan-Zhi He, Ya-Kun Meng, Yan-Zhong Han, Zhen-Fang Zhang, Ping Yin, Xiu-Xiu Sang, Xiao-He Xiao, Zhao-Fang Bai
This paper was aimed to investigate the protective effects of luteolin (Lut) against acetaminophen(APAP)-induced damage in L02 liver cells. CCK-8 was used to detect the cell activation of L02 cells treated by different Lut. The concentration and time of APAP induced L02 cell damage was screened. The effect of Lut on APAP induced apoptosis of L02 cells was detected by cell morphological observation, CCK-8 assay and flow cytometry. The contents of MDA, GSH and SOD activity in cell supernatant were detected by colorimetric assay...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28931410/lentivirus-mediated-interleukin-1%C3%AE-il-1%C3%AE-knock-down-in-the-hippocampus-alleviates-lipopolysaccharide-lps-induced-memory-deficits-and-anxiety-and-depression-like-behaviors-in-mice
#17
Mengmeng Li, Chenli Li, Hanjie Yu, Xiongxiong Cai, Xinbei Shen, Xin Sun, Jinting Wang, Yanhua Zhang, Chuang Wang
BACKGROUND: Recent evidence has suggested that peripheral inflammatory responses induced by lipopolysaccharides (LPS) play an important role in neuropsychiatric dysfunction in rodents. Interleukin-1β (IL-1β), a pro-inflammatory cytokine, has been proposed to be a key mediator in a variety of behavioral dysfunction induced by LPS in mice. Thus, inhibition of IL-1β may have a therapeutic benefit in the treatment of neuropsychiatric disorders. However, the precise underlying mechanism of knock-down of IL-1β in repairing behavioral changes by LPS remains unclear...
September 20, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28931163/influence-of-quercetin-in-the-temporal-regulation-of-redox-homeostasis-in-drosophila-melanogaster
#18
Perumal Subramanian, Kanimozhi Kaliyamoorthy, Jaime Jacqueline Jayapalan, Puteri Shafinaz Abdul-Rahman, Onn Haji Hashim
Numerous biological processes are governed by the biological clock. Studies using Drosophila melanogaster (L.) are valuable that could be of importance for their effective applications on rodent studies. In this study, the beneficial role of quercetin (a flavonoid) on H2O2 induced stress in D. melanogaster was investigated. D. melanogaster flies were divided into four groups (group I - control, group II - H2O2 (acute exposure), group III - quercetin, and group IV - quercetin + H2O2 treated). Negative geotaxis assay, oxidative stress indicators (protein carbonyls, thiobarbituric reactive substances [TBARS]), and antioxidants (superoxide dismutase [SOD], catalase [CAT], glutathione-S-transferase [GST], glutathione peroxidase, and reduced glutathione [GSH]) were measured at 4 h intervals over 24 h and temporal expression of heat shock protein-70 (Hsp70), Upd1 (homolog of IL-6 in Drosophila), and nitric oxide synthase (Nos) was analyzed by Western blotting...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28929661/-evaluation-of-effect-of-supplementing-qi-and-activating-blood-decoction-based-on-combined-model-of-intestinal-out-cardiac-muscle-cells-and-discussion-of-its-mechanism
#19
Ya Geng, Hong-Jun Yang, Yue-Xiang Ma, Jing-Jing Zhang, Yi Zhang, De-Feng Li, Fang-Bo Zhang, Hai-Yu Xu
This research firstly establishes the oxidative damage model of H9c2 induced by H2O2 and screens the concentration range of intestines absorption liquid of Qi benefiting and blood circulation activating formula which possess external myocardium protection function. Then, the thesis chooses 4 dosages to conduct experiments:examining the protection function of intestines absorption liquid of Qi benefiting and blood circulation activating formula on H9c2 to provide reference for clinical prevention and curing of relative heart diseases of oxidative stress injury; as well as examining the H9c2 cardiac muscle cell vigour, cellular morphology, SOD, MDA and other indexes to primarily evaluate and discuss the functional mechanism of intestines absorption liquid of Qi benefiting and blood circulation activating formula...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929270/mode-of-treatment-governs-curcumin-response-on-doxorubicin-induced-toxicity-in-cardiomyoblasts
#20
Aditi Jain, Vibha Rani
Doxorubicin (Dox) is an effective anti-cancer drug with severe reported cardiotoxicity. Cardiovascular risks associated with present cancer therapeutics demand urgent attention. There has been a growing interest in naturally occurring compounds to improve the therapeutic index as well as prevent non-tumour tissues from sustaining chemotherapy-induced damages. In the present study, the effects of curcumin, a polyphenol isolated from Curcuma longa and well known for its anti-oxidative, anti-cancerous and anti-inflammatory properties, was studied in relation to the Dox-induced cardiotoxicity...
September 19, 2017: Molecular and Cellular Biochemistry
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