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https://www.readbyqxmd.com/read/28531990/safety-protocol-for-the-gold-nanoparticles-administration-in-rats
#1
Alexandre Pastoris Muller, Gabriela Kozuchovski Ferreira, Sabrina da Silva, Renata Tiscoski Nesi, Gustavo de Bem Silveira, Carolini Mendes, Ricardo A Pinho, Marcos Marques da Silva Paula, Paulo Cesar Lock Silveira
Gold nanoparticles (GNPs) have antioxidant and anti-inflammatory effects. However, toxicity is still a concern; therefore, it is critical to study both the therapeutic and toxic properties of GNPs. In this study, we evaluated the effects of the intraperitoneal administration of GNPs (20nm, at a concentration of 2.5mg/L for 21days) every 24 or 48h on oxidative stress, antioxidant status, and electron chain transport (ETC) in the brain. Liver histology and blood marker analyses were conducted to establish a time routine of GNP administration...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531922/protective-effect-of-averrhoa-bilimbi-l-fruit-extract-on-ulcerative-colitis-in-wistar-rats-via-regulation-of-inflammatory-mediators-and-cytokines
#2
Jagadish Kumar Suluvoy, Sakthivel K M, Guruvayoorappan C, Berlin Grace V M
Ulcerative Colitis (UC) is a lingering type of Inflammatory Bowel Disease (IBD) which affects the colon mucosa. Ulcerative colitis is majorly associated with oxidative stress and inflammation in colon tissue leading to damage. Averrhoa bilimbi L. fruit is rich in antioxidant phytochemicals including Vitamin C. In the current research, we have evaluated the defence mechanism of Averrhoa bilimbi L. on Ulcerative Colitis (UC). Male wistar rats were treated with Averrhoa bilimbi L. fruit extract (50mg/kg/bwt and 100mg/kg/bwt) and a standard drug Sulfasalazine (100mg/kg/bwt) for 6 consecutive days via intra peritoneally...
May 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28531918/protective-effect-of-ethanolic-extract-of-urtica-urens-l-against-the-toxicity-of-imidacloprid-on-bone-remodeling-in-rats-and-antioxidant-activities
#3
Massara Mzid, Riadh Badraoui, Sameh Ben Khedir, Zouheir Sahnoun, Tarek Rebai
Imidacloprid (IMI) is very harmful to human health and cause problems. Recently, plants have been considered as potential agents for protection against these disorders. Urtica urens L. (UU) is very useful for relieving rheumatic pains and there is no scientific evidence justifying its use, which lets us think of its direct effect on the bone. This study aimed to investigate the protective effect of UU against toxicity effects of IMI in female rat. Rats were divided into control group, 3 groups treated with IMI at 50, 200 or 300mg/kg/day and 3 groups co-treated with IMI (50, 200 or 300mg/kg/day)+100mg/kg/day of UU...
May 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28531838/antimicrobial-agents-triclosan-chloroxylenol-methylisothiazolinone-and-borax-used-in-cleaning-had-genotoxic-and-histopathologic-effects-on-rainbow-trout
#4
Erol Capkin, Tuna Ozcelep, Sevki Kayis, Ilhan Altinok
Triclosan (TRC), chloroxylenol (PCMX) and methylisothiazolinone (MIT) have been commonly used as an antimicrobial in soaps while borax (BRX) is used in household cleaning. After using these chemicals, they are washed down drains and getting into the aquatic ecosystem in which they may affect aquatic living organisms. In the present study, the chronic effects of TRC, PCMX, MIT and BRX on genotoxicity, gene expression and histopathology of rainbow trout (Oncorhynchus mykiss) were evaluated for 40 days under semi static condition...
May 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/28531761/3%C3%AE-hydroxy-urs-12-en-28-oic-acid-confers-protection-against-znonps-induced-adversity-in-caenorhabditis-elegans
#5
Hema Negi, Shilpi Khare Saikia, Ranjana Kanaujia, Satish Jaiswal, Rakesh Pandey
Despite their well reported potent risk towards human health and environment Zinc oxide nanoparticles (ZnONPs) find an extensive commercial usage due to their antimicrobial properties. Here, we evaluated the efficacy of a natural triterpene ursolic acid (3β-hydroxy-urs-12-en-28-oic acid; UA) for overcoming the cytotoxic challenges of ZnONPs employing Ceanorhabditis elegans. The 24h LC50 of Zn-ONPs (<50nm TEM) was deduced as 4.75mgL(-1). UA (25μM) was observed to defend against this toxicity by attenuating Reactive Oxygen Species (ROS) resulting into better survival at 2mgL(-1) in a time dependent behavior...
May 8, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28530295/dose-and-chemical-species-specific-effects-of-selenium-against-arsenite-toxicity-in-cultured-hepatocytes-of-rainbow-trout-oncorhynchus-mykiss
#6
Ankur Jamwal, Som Niyogi
The present study evaluated the mechanistic underpinnings of the interactive effects of selenium (Se), both inorganic (selenite) and organic (selenomethionine (SeMet)), against arsenite (As-III) cytotoxicity using rainbow trout (Oncorhynchus mykiss) hepatocytes in primary culture. Arsenite is known to induce cytotoxic effects by disrupting cellular redox homeostasis. In contrast, Se is essential for the maintenance of cellular anti-oxidative machinery, but when present above a threshold concentration, can also induce reactive oxygen species (ROS) generation and cause oxidative damage...
May 22, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28529531/the-protective-effect-of-lavender-essential-oil-and-its-main-component-linalool-against-the-cognitive-deficits-induced-by-d-galactose-and-aluminum-trichloride-in-mice
#7
Pan Xu, Kezhu Wang, Cong Lu, Liming Dong, Li Gao, Ming Yan, Silafu Aibai, Yanyan Yang, Xinmin Liu
Lavender essential oil (LO) is a traditional medicine used for the treatment of Alzheimer's disease (AD). It was extracted from Lavandula angustifolia Mill. This study was designed to investigate the effects of lavender essential oil (LO) and its active component, linalool (LI), against cognitive impairment induced by D-galactose (D-gal) and AlCl3 in mice and to explore the related mechanisms. Our results revealed that LO (100 mg/kg) or LI (100 mg/kg) significantly protected the cognitive impairments as assessed by the Morris water maze test and step-though test...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28529240/protective-effects-of-curcumin-on-manganese-induced-bv-2-microglial-cell-death
#8
Euteum Park, Hong Sung Chun
Curcumin, a bioactive component in tumeric, has been shown to exert antioxidant, anti-inflammatory, anticarcinogenic, hepatoprotective, and neuroprotective effects, but the effects of curcumin against manganese (Mn)-mediated neurotoxicity have not been studied. This study examined the protective effects of curcumin on Mn-induced cytotoxicity in BV-2 microglial cells. Curcumin (0.1-10 μM) dose-dependently prevented Mn (250 μM)-induced cell death. Mn-induced mitochondria-related apoptotic characteristics, such as caspase-3 and -9 activation, cytochrome c release, Bax increase, and Bcl-2 decrease, were significantly suppressed by curcumin...
May 20, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28529177/senecio-brasiliensis-impairs-eclosion-rate-and-induces-apoptotic-cell-death-in-larvae-of-drosophila-melanogaster
#9
Giulianna Echeverria Macedo, Karen Kich Gomes, Nathane Rosa Rodrigues, Illana Kemmerich Martins, Gabriel da Luz Wallau, Nélson Rodrigues de Carvalho, Litiele Cezar da Cruz, Dennis Guilherme da Costa Silva, Aline Augusti Boligon, Jeferson Luis Franco, Thaís Posser
Senecio brasilienis (Spreng) Less., is a species native from Brazil, popularly known as "maria mole", and known to induce hepatotoxicity due to its high content of Pyrrolizidine alkaloids. Despite its toxicity, this plant is widely used in Brazilian folk medicine. Considering the antagonizing effects described for S. brasiliensis, we describe here molecular markers involved in the toxicity of hydroalcoholic extract from leaves of S. brasiliensis (HESB) in Drosophila melanogaster. Phytochemical analysis of HESB revealed the presence of phenolic acids and flavonoids...
May 18, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28528516/combined-effects-of-chinese-medicine-feed-and-ginger-extract-bath-on-co-infection-of-ichthyophthirius-multifiliis-and-dactylogyrus-ctenopharyngodonid-in-grass-carp
#10
Yao-Wu Fu, Bin Wang, Qi-Zhong Zhang, De-Hai Xu, De-Jie Lin, Xing-Ya Yang, Shu-Qun Zhu, Jing-Yang Pan, Qian Deng, Yan-Meng Liu, Sheng-Yu Zhou
Dactylogyrus ctenopharyngodonid and Ichthyophthirius multifiliis are two important ectoparasites of freshwater fish. Co-infection by the two parasites leads to high fish mortality and results in heavy economic losses. This study aimed to evaluate the efficacy of medicated feed and a ginger extract bath against D. ctenopharyngodonid and I. multifiliis on grass carp and investigate the hematological response of grass carp co-infected by the two parasites. These results demonstrated that red blood cell (RBC) and thrombocyte percentage among leucocytes significantly decreased after grass carp were co-infected by D...
May 20, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28528415/oxidative-stress-in-shellfish-sinonovacula-constricta-exposed-to-the-water-accommodated-fraction-of-zero-sulfur-diesel-oil-and-pinghu-crude-oil
#11
Mei Jiang, Lei Li, Yingren Li, Gongming Shen, Xinqiang Shen
This study investigated the oxidative stress of the water accommodated fraction (WAF) of zero sulfur diesel oil and Pinghu crude oil on Sinonovacula constricta, respectively. The oxidative stress of oil pollutants on organisms was measured by typical antioxidases, such as SOD, CAT, GST, and POD. Toxicity was quantitatively evaluated by combining IBR (integrated biomarker responses). Results demonstrated that different concentrations of oil caused different degrees of induction to the four antioxidases. Compared with the control group, all test groups presented enzyme induction or inhibition during exposure period...
May 20, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28528318/metabolic-profiling-of-goldfish-carassius-auratis-after-long-term-glyphosate-based-herbicide-exposure
#12
Ming-Hui Li, Ling-Yu Ruan, Jin-Wei Zhou, Yong-Hong Fu, Lei Jiang, He Zhao, Jun-Song Wang
Glyphosate is an efficient herbicide widely used worldwide. However, its toxicity to non-targeted organisms has not been fully elucidated. In this study, the toxicity of glyphosate-based herbicide was evaluated on goldfish (Carassius auratus) after long-term exposure. Tissues of brains, kidneys and livers were collected and submitted to NMR-based metabolomics analysis and histopathological inspection. Plasma was collected and the blood biochemical indexes of AST, ALT, BUN, CRE, LDH, SOD, GSH-Px, GR and MDA were measured...
May 13, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28528260/hexavalent-chromium-induced-oxidative-stress-and-apoptosis-in-pycnoporus-sanguineus
#13
Mi Feng, Hua Yin, Hui Peng, Zehua Liu, Guining Lu, Zhi Dang
White rot fungi have been proved to be a promising option for the removal of heavy metals, understanding their toxic response to heavy metals is conducive to developing and popularizing fungi-based remediation technologies so as to lessen the hazard of heavy metals. In this study, Cr(VI)-induced oxidative stress and apoptosis in Pycnoporus sanguineus, a species of white rot fungi were investigated. The results suggested that high level of Cr(VI) promoted the formation of ROS, including H2O2, O2(•-) and ·OH...
May 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28527975/the-reaumuria-trigyna-transcription-factor-rtwrky1-confers-tolerance-to-salt-stress-in-transgenic-arabidopsis
#14
Chao Du, Pingping Zhao, Huirong Zhang, Ningning Li, Linlin Zheng, Yingchun Wang
Reaumuria trigyna (R. trigyna) is an endangered small shrub endemic to the Eastern Alxa-Western Ordos area in Inner Mongolia, China. Based on R. trigyna transcriptome data, the Group I WRKY transcription factor gene RtWRKY1 was cloned from R. trigyna. The full-length RtWRKY1 gene was 2100bp, including a 1261-bp open reading frame (ORF) encoding 573 amino acids. RtWRKY1 was mainly expressed in the stem and was induced by salt, cold stress, and ABA treatment. Overexpression of RtWRKY1 in Arabidopsis significantly enhanced the chlorophyll content, root length, and fresh weight of the transgenic lines under salt stress...
May 4, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28527417/fate-of-the-sunscreen-compound-oxybenzone-in-cyperus-alternifolius-based-hydroponic-culture-uptake-biotransformation-and-phytotoxicity
#15
Feiran Chen, Christian Huber, Peter Schröder
Oxybenzone (OBZ), a common ingredient in sunscreens and personal care products, has been frequently detected in effluents from municipal wastewater treatment plants and also in surface waters. OBZ is an emerging contaminant due to its adverse impacts on marine/aquatic ecosystems. To investigate the removal and degradation capacity of phytotreatment for OBZ, the common wetland plant species Cyperus alternifolius L. was exposed to this compound at 5, 25 and 50 μM for 120 h, respectively. Continuous uptake by roots and accumulation in plant tissues was observed over the exposure time, and depletion of spiked OBZ from the aqueous medium exceeded 73...
May 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28526985/salidroside-attenuates-lps-induced-acute-lung-injury-in-rats
#16
Liu Jingyan, Guo Yujuan, Yang Yiming, Zhu Lingpeng, Yan Tianhua, Miao Mingxing
The purpose of the present study was to investigate the effects of salidroside (Sal) on lung injury in lipopolysaccharide (LPS)-induced endotoxemic in vitro and in vivo. SD rats were randomly divided into five groups: control group, LPS group (15 mg kg(-1)), LPS plus dexamethasone (2 mg kg(-1)), and LPS plus Sal groups with different Sal doses (20 mg kg(-1), 40 mg kg(-1)). Wet-to-dry weight (W/D) ratio was performed. Hematoxylin-eosin (HE) staining of lung was performed. Lung level of myeloperoxidase (MPO) was measured...
May 19, 2017: Inflammation
https://www.readbyqxmd.com/read/28526935/diabetes-induced-abnormalities-of-mitochondrial-function-in-rat-brain-cortex-the-effect-of-n-3-fatty-acid-diet
#17
Maria Chomova, Maria Balazova, Jana Muchova
Diabetic encephalopathy, a proven complication of diabetes is associated with gradually developing end-organ damage in the CNS increasing the risk of stroke, cognitive dysfunction or Alzheimer's disease. This study investigated the response of rat cortical mitochondria to streptozotocin-induced diabetes and the potential for fish oil emulsion (FOE) to modulate mitochondrial function. Diabetes-induced deregulation of the respiratory chain function as a result of diminished complex I activity (CI) and cytochrome c oxidase hyperactivity was associated with attenuation of antioxidant defense of isolated cortical mitochondria, monitored by SOD activity, the thiol content, the dityrosine and protein-lipid peroxidation adduct formation...
May 19, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28524802/effects-of-occupational-silica-exposure-on-oxidative-stress-and-immune-system-parameters-in-ceramic-workers-in-turkey
#18
Hatice Gul Anlar, Merve Bacanli, Servet İritaş, Ceylan Bal, Türker Kurt, Engin Tutkun, O Hinc Yilmaz, Nursen Basaran
Silica is the second most common element after oxygen, and therefore, exposures to crystalline silica dust occur in a large variety of occupations such as metal foundries, constructions, and ceramic, quarry, and pottery industries. Since crystalline silica exposure has been linked with silicosis, lung cancer, and other pulmonary diseases, adverse effect attributed to this element has be a cause for concern worldwide. Silica dust exposure in workers is still considered to be important health problem especially in developing countries...
May 19, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28524089/green-synthesized-zinc-oxide-zno-nanoparticles-induce-oxidative-stress-and-dna-damage-in-lathyrus-sativus-l-root-bioassay-system
#19
Kamal K Panda, Dambaru Golari, A Venugopal, V Mohan M Achary, Ganngam Phaomei, Narasimham L Parinandi, Hrushi K Sahu, Brahma B Panda
Zinc oxide nanoparticles (ZnONP-GS) were synthesised from the precursor zinc acetate (Zn(CH₃COO)₂) through the green route using the milky latex from milk weed (Calotropis gigantea L. R. Br) by alkaline precipitation. Formation of the ZnONP-GS was monitored by UV-visible spectroscopy followed by characterization and confirmation by energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), and X-ray diffraction (XRD). Both the ZnONP-GS and the commercially available ZnONP-S (Sigma-Aldrich) and cationic Zn(2+) from Zn(CH₃COO)₂ were tested in a dose range of 0-100 mg·L(-1) for their potency (i) to induce oxidative stress as measured by the generation reactive oxygen species (ROS: O₂(•-), H₂O₂ and (•)OH), cell death, and lipid peroxidation; (ii) to modulate the activities of antioxidant enzymes: catalase (CAT), superoxide dismutase (SOD), guaiacol peroxidase (GPX), and ascorbate peroxidase (APX); and (iii) to cause DNA damage as determined by Comet assay in Lathyrus sativus L...
May 18, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28524081/protective-effects-of-tormentic-acid-a-major-component-of-suspension-cultures-of-eriobotrya-japonica-cells-on-acetaminophen-induced-hepatotoxicity-in-mice
#20
Wen-Ping Jiang, Shyh-Shyun Huang, Yoshikazu Matsuda, Hiroshi Saito, Naoto Uramaru, Hui-Ya Ho, Jin-Bin Wu, Guan-Jhong Huang
An acetaminophen (APAP) overdose can cause hepatotoxicity and lead to fatal liver damage. The hepatoprotective effects of tormentic acid (TA) on acetaminophen (APAP)-induced liver damage were investigated in mice. TA was intraperitoneally (i.p.) administered for six days prior to APAP administration. Pretreatment with TA prevented the elevation of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (T-Bil), total cholesterol (TC), triacylglycerol (TG), and liver lipid peroxide levels in APAP-treated mice and markedly reduced APAP-induced histological alterations in liver tissues...
May 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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