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Diabetic macula

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https://www.readbyqxmd.com/read/28427062/emerging-issues-for-optical-coherence-tomography
#1
Luisa Pierro, Alessandro Rabiolo
Almost 25 years after its introduction, optical coherence tomography (OCT) is still a crucial test in the evaluation of patients affected by diabetic retinopathy. In this chapter, the authors provide an extensive overview of the posterior segment pathological changes induced by diabetes, characterized using OCT. OCT plays a key role in diabetic macular edema (DME) as it assesses related retinal changes both in a qualitative (i.e., DME pattern, presence and aspects of cysts, fluid localization, integrity, and reflectivity of retinal layers) and quantitative (i...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28393035/retinal-ganglion-cell-complex-changes-using-spectral-domain-optical-coherence-tomography-in-diabetic-patients-without-retinopathy
#2
Ahmed I Hegazy, Rasha H Zedan, Tamer A Macky, Soheir M Esmat
AIM: To assess the ganglion cell complex (GCC) thickness in diabetic eyes without retinopathy. METHODS: Two groups included 45 diabetic eyes without retinopathy and 21 non diabetic eyes. All subjects underwent full medical and ophthalmological history, full ophthalmological examination, measuring GCC thickness and central foveal thickness (CFT) using the RTVue(®) spectral domain-optical coherence tomography (SD-OCT), and HbA1C level. RESULTS: GCC focal loss volume (FLV%) was significantly more in diabetic eyes (22...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28381459/urinary-adenosine-excretion-in-type-1-diabetes
#3
Harindra Rajasekeran, Yuliya Lytvyn, Andrea Bozovic, Julie Lovshin, Eleftherios Diamandis, Daniel Cattran, Mansoor Husain, Bruce A Perkins, Andrew Advani, Heather N Reich, Vathany Kulasingam, David Z I Cherney
INTRODUCTION: In experimental models of diabetes, augmented sodium-glucose cotransport-2 (SGLT2) activity diminishes sodium (Na+) delivery at the macula densa. As a result, less vasoconstrictive adenosine is generated, leading to afferent arteriolar vasodilatation and hyperfiltration. The measurement and significance of urinary adenosine in humans has not been extensively examined in states of renal hemodynamic impairment, like that of diabetes. OBJECTIVE: Our aim was to validate a method for urine adenosine quantification in humans and perform an exploratory post-hoc analysis to determine whether urinary adenosine levels change dynamically in response to natriuresis in patients with type 1 diabetes (T1D) before and after treatment with the SGLT2 inhibitor (SGLT2i) empagliflozin...
April 5, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28377846/a-quantitative-approach-to-predict-differential-effects-of-anti-vegf-treatment-on-diffuse-and-focal-leakage-in-patients-with-diabetic-macular-edema-a-pilot-study
#4
Michael J Allingham, Dibyendu Mukherjee, Erin B Lally, Hossein Rabbani, Priyatham S Mettu, Scott W Cousins, Sina Farsiu
PURPOSE: We use semiautomated segmentation of fluorescein angiography (FA) to determine whether anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular edema (DME) differentially affects microaneurysm (MA)-associated leakage, termed focal leakage, versus non-MA-associated leakage, termed diffuse leakage. METHODS: We performed a retrospective study of 29 subjects treated with at least three consecutive injections of anti-VEGF agents for DME (mean 4...
March 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28366367/evaluation-of-the-effect-of-intracameral-cefuroxime-on-macular-and-subfoveal-choroidal-thickness-and-macular-sensitivity%C3%A2-in%C3%A2-diabetic-patients-after-cataract%C3%A2-surgery
#5
Bo Ma, Yan Liu, Shaorui Liu, Min Luo
PURPOSE: To evaluate the macular and subfoveal choroidal thickness variation and macular sensitivity changes in diabetic patients after intracameral cefuroxime in cataract surgery. SETTING: Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai, China. DESIGN: Prospective case series. METHODS: Diabetic patients with visually significant cataract were divided into a treatment group, which received an intracameral injection of 1 mg/0...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28351052/diabetic-macular-edema
#6
Francesco Bandello, Maurizio Battaglia Parodi, Paolo Lanzetta, Anat Loewenstein, Pascale Massin, Francesca Menchini, Daniele Veritti
Diabetic macular edema (DME), defined as a retinal thickening involving or approaching the center of the macula, represents the most common cause of vision loss in patients affected by diabetes mellitus. In the last few years, many diagnostic tools have proven to be useful in the detection and the monitoring of the features characterizing DME. On the other hand, several therapeutic approaches can now be proposed on the basis of the DME-specific characteristics. The aim of the present chapter is to thoroughly delineate the clinical and morphofunctional characteristics of DME and its current treatment perspectives...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28346545/aqueous-cytokine-levels-are-associated-with-reduced-macular-thickness-after-intravitreal-ranibizumab-for-diabetic-macular-edema
#7
Tomoyasu Shiraya, Satoshi Kato, Fumiyuki Araki, Takashi Ueta, Tempei Miyaji, Takuhiro Yamaguchi
PURPOSE: It is controversial whether the administration of anti-vascular endothelial growth factor drugs for diabetic macular edema (DME) affects intraocular inflammatory cytokines. In this study, we measured cytokine concentration in aqueous humor before and after intravitreal injection of ranibizumab (IVR). The aim was to determine changes in cytokine concentration and their effects on DME reduction. METHODS: Twelve patients (13 eyes) with DME received two IVR (0...
2017: PloS One
https://www.readbyqxmd.com/read/28343061/automated-diabetic-macular-edema-dme-grading-system-using-dwt-dct-features-and-maculopathy-index
#8
U Rajendra Acharya, Muthu Rama Krishnan Mookiah, Joel E W Koh, Jen Hong Tan, Sulatha V Bhandary, A Krishna Rao, Yuki Hagiwara, Chua Kuang Chua, Augustinus Laude
The cause of diabetic macular edema (DME) is due to prolonged and uncontrolled diabetes mellitus (DM) which affects the vision of diabetic subjects. DME is graded based on the exudate location from the macula. It is clinically diagnosed using fundus images which is tedious and time-consuming. Regular eye screening and subsequent treatment may prevent the vision loss. Hence, in this work, a hybrid system based on Radon transform (RT), discrete wavelet transform (DWT) and discrete cosine transform (DCT) are proposed for an automated detection of DME...
March 19, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28339297/long-term-effect-of-panretinal-photocoagulation-on-spectral-domain-optical-coherence-tomography-measurements-in-diabetic-retinopathy
#9
Haeng-Jin Lee, Tae-Seen Kang, Baek-Soo Kwak, Young-Joon Jo, Jung-Yeul Kim
PURPOSE: To evaluate the effects of panretinal photocoagulation on spectral domain optical coherence tomography measurements in diabetic retinopathy by comparing the thicknesses of the central macula, retinal nerve fiber layer, and ganglion cell layer, we used a Cirrus HD OCT® (Carl Zeiss Meditec, Dublin, CA, USA) in normal and diabetic retinopathy cohorts. METHODS: We analyzed patients who visited our retinal clinic between May 2013 and July 2014. The patients were classified into four groups: normal (Group A), diabetes without diabetic retinopathy (Group B), severe nonproliferative or proliferative diabetic retinopathy (Group C), and at least 3 years after panretinal photocoagulation treatment (Group D)...
March 24, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28334035/early-inner-retinal-thinning-and-cardiovascular-autonomic-dysfunction-in-type-2-diabetes
#10
Jin A Choi, Hyo Won Kim, Jin-Woo Kwon, Yun-Sub Shim, Dong Hyun Jee, Jae-Seung Yun, Yu-Bae Ahn, Chan Kee Park, Seung-Hyun Ko
BACKGROUND: To investigate changes in the neural retina according to the presence of retinal nerve fiber layer (RNFL) defects in type 2 diabetes, and to determine the association between inner retina thickness and the severity of diabetic complications. METHODS: We studied non-glaucomatous patients with type 2 diabetes and control subjects Circumpapillary RNFL and macula ganglion cell-inner plexiform layer (GCIPL) thicknesses were measured by spectral-domain optical coherence tomography...
2017: PloS One
https://www.readbyqxmd.com/read/28260851/anti-vegf-treatment-of-diabetic-macular-edema-in-clinical-practice-effectiveness-and-patterns-of-use-echo-study-report-1
#11
Kevin J Blinder, Pravin U Dugel, Sanford Chen, J Michael Jumper, John G Walt, David A Hollander, Lanita C Scott
PURPOSE: To evaluate the efficacy, safety, and injection frequency of vascular endothelial growth factor (VEGF) inhibitors as used in clinical practice for the treatment of diabetic macular edema. METHODS: Multicenter (10 sites), retrospective chart review in patients (n=156) who received ≥3 anti-VEGF injections. Data collected for ≥6 months after the first injection included Snellen best-corrected visual acuity (BCVA) and central retinal thickness (CRT) by time-domain or spectral-domain optical coherence tomography (TD-OCT or SD-OCT)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28243608/visual-acuity-retinal-sensitivity-and-macular-thickness-changes-in-diabetic-patients-without-diabetic-retinopathy-after-cataract-surgery
#12
Spela Stunf Pukl, Nataša Vidović Valentinčič, Mojca Urbančič, Irena Irman Grčar, Rok Grčar, Vladimir Pfeifer, Mojca Globočnik Petrovič
Aim. Functional and morphological macular study after cataract surgery in a group of diabetics without diabetic retinopathy compared to nondiabetics to evaluate the effect of surgical oxidative stress on diabetic retina. Methods. Prospective, comparative study. Preoperative eye exam, best corrected visual acuity (BCVA) measured by ETDRS letters, and optical coherence tomography (OCT) were followed by standard cataract surgery. The follow-up visits at 1, 3, and 6 months postoperatively included BCVA, OCT, and microperimetry, to analyze changes within and between the groups...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28237428/slow-release-dexamethasone-in-proliferative-vitreoretinopathy-a-prospective-randomized-controlled-clinical-trial
#13
Philip J Banerjee, Ana Quartilho, Catey Bunce, Wen Xing, Tapiwa M Zvobgo, Nicola Harris, David G Charteris
PURPOSE: To test the hypothesis that adjunctive slow-release dexamethasone implant (Ozurdex; Allergan Inc, Irvine, CA) can improve the outcomes of vitreoretinal surgery for established proliferative vitreoretinopathy (PVR). DESIGN: A 2-year, single-center, prospective, participant- and surgeon-masked randomized controlled clinical trial (EudraCT No. 2011-004498-96). PARTICIPANTS: A total of 140 patients requiring vitrectomy surgery with silicone oil for retinal detachment with established PVR (Grade C) were randomized to standard (control) or study treatment (adjunct) in a 1:1 allocation ratio...
February 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28208170/optical-coherence-tomographic-angiography-in-type-2-diabetes-and-diabetic-retinopathy
#14
Daniel Shu Wei Ting, Gavin Siew Wei Tan, Rupesh Agrawal, Yasuo Yanagi, Nicole Ming Sie, Chee Wai Wong, Ian Yew San Yeo, Shu Yen Lee, Chui Ming Gemmy Cheung, Tien Yin Wong
Importance: Optical coherence tomographic angiography (OCT-A) is able to visualize retinal microvasculature without the need for injection of fluorescein contrast dye. Nevertheless, it is only able to capture a limited view of macula and does not show leakage. Objectives: To evaluate the retinal microvasculature using OCT-A in patients with type 2 diabetes as well as the association of OCT-A characteristics with diabetic retinopathy (DR) and systemic risk factors...
February 16, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28203186/real-life-iluvien-fluocinolone-acetonide-case-study-rapid-drying-of-the-macula-and-improved-vision-within-2-years-after-therapy-initiation
#15
Hibba Quhill, Fahd Quhill
IMPORTANCE: A case showing sustained structural and functional responses 2 years after a single treatment with ILUVIEN (0.2 µg/day fluocinolone acetonide, FAc) despite suboptimal responses to ranibizumab. OBSERVATIONS: A 68-year-old female patient with diabetic macular oedema (DME) from type 2 diabetes mellitus was first diagnosed in October 2010 and had a baseline visual acuity (VA) of 46 Early Treatment Diabetic Retinopathy Study (ETDRS) letters in the left eye...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28168812/optical-coherence-tomography-angiography-of-macular-telangiectasia-type-1-comparison-with-mild-diabetic-macular-edema
#16
Lei Mao, Si-Si Weng, Yuan-Yuan Gong, Su-Qin Yu
OBJECTIVE: The present study aimed to investigate the characteristics of macular telangiectasia type 1 (Mac tel type 1) using spectral-domain optical coherence tomography angiography (OCTA) and compare them with the characteristics of mild diabetic macular edema (DME), to provide a new objective method for quick clinical diagnosis and treatment. METHODS: A retrospective comparative analysis of 9 Mac tel type 1, 15 DME, and 15 normal eyes was performed using fluorescein angiography, spectral-domain optical coherence tomography, and OCTA...
March 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28141748/risk-for-low-visual-acuity-after-1-and-2-years-of-treatment-with-ranibizumab-or-bevacizumab-for-patients-with-neovascular-age-related-macular-degeneration
#17
Inger Westborg, Susanne Albrecht, Aldana Rosso
PURPOSE: To investigate how patients with neovascular age-related macular degeneration treated with ranibizumab or bevacizumab respond to treatment in daily clinical practice. METHODS: Data from the Swedish Macula Register on the treatment received by 3,912 patients during 2011 to 2014 is reported. Patients' characteristics at the first visit, visual acuity, number of injections, and reason for terminating the treatment if applicable are discussed. Furthermore, the risk of having poor vision (visual acuity under 60 Early Treatment Diabetes Retinopathy Study letters or approximately 20/60 Snellen) is calculated for the treated eye after 1 year and 2 years...
January 30, 2017: Retina
https://www.readbyqxmd.com/read/28124146/aniseikonia-in-various-retinal-disorders
#18
Fumiki Okamoto, Yoshimi Sugiura, Yoshifumi Okamoto, Takahiro Hiraoka, Tetsuro Oshika
PURPOSE: The purpose was to quantify and compare the severity of aniseikonia in patients undergoing vitrectomy for various retinal disorders. METHODS: We studied 357 patients with retinal disorders including epiretinal membrane (ERM), macular hole (MH), cystoid macular edema with branch / central retinal vein occlusion (BRVO-CME / CRVO-CME), diabetic macular edema (DME), macula-off rhegmatogenous retinal detachment (M-off RD), and macula-on RD (M-on RD) as well as 31 normal controls...
January 25, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28114356/co-evaluation-of-peripapillary-rnfl-thickness-and-retinal-thickness-in-patients-with-diabetic-macular-edema-rnfl-misinterpretation-and-its-adjustment
#19
Hyun Seung Yang, Jong Eun Woo, Min-Ho Kim, Dong Yoon Kim, Young Hee Yoon
We investigated the relationship between the peripapillary retinal nerve fiber layer and peripapillary retinal thickness in patients with diabetic macular edema. Fifty eyes (group I) with non-proliferative diabetic retinopathy and diabetic macular edema receiving intravitreal anti-VEGF injection, and 90 eyes (group II) without diabetic macular edema were included in this case-control study. The peripapillary retinal nerve fiber layer thickness, peripapillary retinal thickness, and a new retinal nerve fiber layer index using a modeled relationship between the two parameters were evaluated with spectral-domain optical coherence tomography, at baseline and at the 6-month follow-up...
2017: PloS One
https://www.readbyqxmd.com/read/28092344/choriocapillaris-signal-voids-in-maternally-inherited-diabetes-and-deafness-and-in-pseudoxanthoma-elasticum
#20
Richard F Spaide
PURPOSE: To evaluate the pattern of choriocapillaris signal voids in maternally inherited diabetes and deafness and in pseudoxanthoma elasticum in eyes before the development of any geographic atrophy. METHODS: The choriocapillaris under the central macula was imaged with the Optovue RTVue XR Avanti using a 10 μm slab thickness. Automatic local thresholding of the resultant raw data extracted areas of absent flow signal, called signal voids, and these were counted and logarithmically binned...
January 13, 2017: Retina
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