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Diabetic macula

Ahmad M Mansour, Robert E Foster, Roberto Gallego-Pinazo, Marilita M Moschos, Robert A Sisk, Jay Chhablani, Duangnate Rojanaporn, Tharikarn Sujirakul, J Fernando Arevalo, Luiz H Lima, Lihteh Wu, Abdulrazzak Charbaji, Ali O Saatci, Hana A Mansour, Clara Martinez-Rubio, Yogin Patel, Sankeert Gangakhedkar
PURPOSE: There is no established therapy for exudative-hemorrhagic complications in primary retinal arteriolar macroaneurysm (RAM). METHODS: Retrospective multicenter interventional study of anti-vascular endothelial growth factor in symptomatic RAMs. Central macular thickness in μm and best-corrected visual acuity in logMar were correlated with the RAM size and distance to the macula. Statistical analyses were performed using paired comparisons and Pearson correlation...
March 2, 2018: Retina
Berthold Pemp, Stefan Palkovits, Kinga Howorka, Jiri Pumprla, Stefan Sacu, Gerhard Garhöfer, Michaela Bayerle-Eder, Leopold Schmetterer, Ursula Schmidt-Erfurth
PURPOSE: To evaluate the relationship of neuroretinal layer thickness with sensitive measures of cardiovascular autonomic neuropathy in diabetic patients with non-proliferative diabetic retinopathy (NPDR). METHODS: Twenty-seven eyes of 27 patients with type 1 diabetes presenting with mild-to-moderate NPDR were compared to 27 healthy control (HC) eyes matched for age and gender. The total macular volume (TMV) and the volumes of individual neurosensory layers in the macula were analysed from spectral domain optical coherence tomography using automated layer segmentation...
March 5, 2018: Acta Ophthalmologica
Yusuke Kameda, Akira Hirose, Tomohiro Iida, Yasuko Uchigata, Shigehiko Kitano
Purpose: To report a case of a giant retinal pigment epithelial (RPE) tear associated with fluid overload in a patient with diabetic macular edema (DME) and kidney disease. Observations: A 60-year-old man with type 2 diabetes mellitus and end-stage diabetic kidney disease who had gained weight because of fluid overload complained of a visual disturbance in the left eye that had started a few days earlier. The left fundus showed a RPE defect in two temporal quadrants under an extensive serous retinal detachment (SRD) with exacerbation of the original DME...
April 2017: American Journal of Ophthalmology Case Reports
Bláithín Ní Bhuachalla, Christine A McGarrigle, Neil O'Leary, Kwadwo Owusu Akuffo, Tunde Peto, Stephen Beatty, Rose Anne Kenny
PURPOSE: Age related macular degeneration (AMD) is a leading cause of irreversible visual loss in developed countries. It is associated with vascular risk factors including hypertension. Dysregulated blood pressure (BP) behaviour including orthostatic hypertension (OHTN), hypotension (OH) and BP variability (BPV) are associated with end-organ damage, particularly in the brain. We investigated if abnormal orthostatic BP (OBP) was a risk factor for AMD, for which a vascular aetiology is implicated...
February 28, 2018: Experimental Gerontology
William Fusi-Rubiano, Chandoshi Mukherjee, Mark Lane, Marie D Tsaloumas, Nicholas Glover, Andrej Kidess, Alastair K Denniston, Helen E Palmer, Avinash Manna, Rupal Morjaria
BACKGROUND: To compare visual function and structural improvements in pseudophakic eyes with diabetic macular oedema (DMO) treated with the 0.19mg Fluocinolone Acetonide (FAc) intravitreal implant (IluvienTM ) in a 'real world' setting. METHODS: A single centre retrospective evaluation of patients with DMO unresponsive to conventional treatment treated with the FAc implant according to UK guidelines. Primary efficacy endpoint was best corrected visual acuity (BCVA); secondary endpoints included optical coherence tomography evaluations of the macula (a) central retinal and (b) peak macular thickness collected at annual time points...
February 27, 2018: BMC Ophthalmology
Aditya Verma, Vikas Khetan
Diabetic retinopathy (DR) is a well-known risk factor in the development of radiation maculopathy (RM). Steroids have been shown to improve the vision and reduce the macular thickness in patients with RM. This observational case report highlights altered course of DR after a course of radiotherapy for orbital lymphoma, after a single dose of intravitreal dexamethasone implant showed a dramatic revascularization of the ischemic macula, with a significant reduction in the size of ischemic area. This appears to be the first case in literature corroborating the favorable effect on steroids on retinal vasculature, seen angiographically...
March 2018: Indian Journal of Ophthalmology
Riccardo Sacconi, Eleonora Corbelli, Adriano Carnevali, Stefano Mercuri, Alessandro Rabiolo, Lea Querques, Giorgio Marchini, Francesco Bandello, Giuseppe Querques
AIMS: To describe optical coherence tomography angiography (OCT-A) abnormalities of patients with pseudophakic cystoid macular oedema (PCMO) before and after pharmacological resolution, compared with diabetic macular oedema (DMO) and normal eyes. METHODS: In this retrospective, observational study, 44 eyes (30 patients) were included: 15 eyes (15 patients) affected by PCMO; 14 healthy fellow eyes used as negative control group; 15 eyes (15 age-matched and sex-matched patients) with DMO used as positive control group...
February 20, 2018: British Journal of Ophthalmology
Khan Bahadar Khan, Amir A Khaliq, Abdul Jalil, Muhammad Shahid
The exploration of retinal vessel structure is colossally important on account of numerous diseases including stroke, Diabetic Retinopathy (DR) and coronary heart diseases, which can damage the retinal vessel structure. The retinal vascular network is very hard to be extracted due to its spreading and diminishing geometry and contrast variation in an image. The proposed technique consists of unique parallel processes for denoising and extraction of blood vessels in retinal images. In the preprocessing section, an adaptive histogram equalization enhances dissimilarity between the vessels and the background and morphological top-hat filters are employed to eliminate macula and optic disc, etc...
2018: PloS One
Hyung-Bin Lim, Jae-Yun Sung, Seung-Il Ahn, Young-Joon Jo, Jung-Yeul Kim
SIGNIFICANCE: Peripapillary retinal nerve fiber layer (RNFL) thickness measurements may be influenced by the range and severity of lesions that are observed distinctively in each retinal disease. PURPOSE: We investigated the effects of various macular (central serous chorioretinopathy, macular hole, epiretinal membrane, wet age-related macular degeneration) and retinal vascular (branch retinal vein occlusion, central retinal vein occlusion, diabetic macular edema) diseases on peripapillary RNFL thickness measurements using spectral-domain optical coherence tomography...
February 7, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Cyrus M Shroff, Charu Gupta, Daraius Shroff, Neelam Atri, Priyanka Gupta, Ranjan Dutta
PURPOSE: To evaluate the visual and anatomical outcomes and safety of bimanual microincision vitreous surgery for severe proliferative diabetic retinopathy. METHODS: Retrospective review of 315 eyes of 282 patients who underwent 23-gauge or 25-gauge pars plana vitrectomy with bimanual membrane dissection for diabetic tractional detachment from January 2007 to September 2016. Minimum follow-up was 3 months, and the average duration of follow-up was 23 months (range 3-100 months; median 15 months)...
February 5, 2018: Retina
Justus G Garweg, Mario Deiss, Isabel B Pfister, Christin Gerhardt
PURPOSE: To assess the impact of inner limiting membrane peeling during vitrectomy for macula-involving retinal detachment on best-corrected visual acuity (VA). METHODS: Retrospective analysis of 89 eyes with primary macula-involving retinal detachment, which was undergoing vitrectomy, endolaser, retinotomy, endodrainage, and SF6 tamponade. Membrane-blue-assisted membrane peeling had been performed in 61 of the eyes (Group 1) but not in the other 28 (Group 2), which served as controls...
February 1, 2018: Retina
Olena Müller, Margarita G Todorova, Torsten Schlote
PURPOSE: We aimed to investigate central macular microvasculature by optical coherence tomography angiography (OCTA) and to analyse its relation to alterations in classical parameters of optical coherence tomography (OCT) in glaucoma patients. METHODS: Using OCTA (Avanti incl. AngioVue; Optovue, Inc., Fremont, CA), the superficial flow (SF) and the superficial non-flow (SNF) area of the macula, as well as the S-ETDRS (based on Early Treatment Diabetic Retinopathy charts)...
February 1, 2018: Klinische Monatsblätter Für Augenheilkunde
Harpal Singh Sandhu, Nabila Eladawi, Mohammed Elmogy, Robert Keynton, Omar Helmy, Shlomit Schaal, Ayman El-Baz
BACKGROUND: Optical coherence tomography angiography (OCTA) is increasingly being used to evaluate diabetic retinopathy, but the interpretation of OCTA remains largely subjective. The purpose of this study was to design a computer-aided diagnostic (CAD) system to diagnose non-proliferative diabetic retinopathy (NPDR) in an automated fashion using OCTA images. METHODS: This was a two-centre, cross-sectional study. Adults with type II diabetes mellitus (DMII) were eligible for inclusion...
January 23, 2018: British Journal of Ophthalmology
David M Brown, William C Ou, Tien P Wong, Rosa Y Kim, Daniel E Croft, Charles C Wykoff
PURPOSE: To evaluate the effect of targeted retinal photocoagulation (TRP) on visual and anatomic outcomes and treatment burden in eyes with diabetic macular edema (DME). DESIGN: Phase I/II prospective, randomized, controlled clinical trial. PARTICIPANTS: Forty eyes of 29 patients with center-involved macular edema secondary to diabetes mellitus. METHODS: Eyes with center-involved DME and Early Treatment Diabetic Retinopathy Study (ETDRS) best-corrected visual acuity (BCVA) between 20/32 and 20/320 (Snellen equivalent) were randomized 1:1 to monotherapy with 0...
January 11, 2018: Ophthalmology
Joana Mesquita, João Paulo Castro-de-Sousa, Sara Vaz-Pereira, Arminda Neves, Luís A Passarinha, Cândida T Tomaz
Vision loss due to disease or degeneration of the eye (retina, choroid, retinal veins, or macula) is a leading cause of blindness worldwide. In most cases, vision-threatening ocular diseases are accompanied by abnormal changes in the vasculature of the eye, especially the retina, and these conditions are collectively referred to as retinal vasculopathies. Impaired blood supply or hypoxia stimulates angiogenesis in the vascular and non-vascular sections of the eye, which results in neovascularization, leading to conditions such as diabetic retinopathy or age-related macular degeneration...
December 7, 2017: Cytokine & Growth Factor Reviews
Steven M Silverstein, Danielle Paterno, Lindsay Cherneski, Stuart Green
BACKGROUND: Prior optical coherence tomography (OCT) studies of schizophrenia have identified thinning of retinal layers. However, findings have varied across reports, and most studies have had serious methodological limitations. To address unresolved issues, we determined whether: (1) retinal thinning in schizophrenia occurs independently of comorbid medical conditions that affect the retina; (2) thinning is independent of antipsychotic medication dose; (3) optic nerve parameters are abnormal in schizophrenia; and (4) OCT indices are related to visual and cognitive impairments common in schizophrenia...
December 13, 2017: Psychological Medicine
Walter Andreatta, Ibrahim Elaraoud, Arijit Mitra
BACKGROUND/PURPOSE: To report a case of dislodgement of an Iluvien (fluocinolone acetonide) intravitreal implant into the infusion cannula during pars plana vitrectomy for retinal detachment. METHODS: The patient's surgery was video recorded, and the medical notes were reviewed retrospectively. RESULTS: A patient developed a macula off retinal detachment over 1 year after intravitreal injection of Iluvien for diabetic maculopathy. The patient underwent pars plana vitrectomy, removal of implant, and successful retinal reattachment...
November 23, 2017: Retinal Cases & Brief Reports
Xiaoming Gong, Christian S Draper, Geoffrey S Allison, Raju Marisiddaiah, Lewis P Rubin
Retinal pigment epithelial (RPE) cells are central to retinal health and homoeostasis. Oxidative stress-induced damage to the RPE occurs as part of the pathogenesis of age-related macular degeneration and neovascular retinopathies (e.g., retinopathy of prematurity, diabetic retinopathy). The xanthophyll carotenoids, lutein and zeaxanthin, are selectively taken up by the RPE, preferentially accumulated in the human macula, and transferred to photoreceptors. These macular xanthophylls protect the macula (and the broader retina) via their antioxidant and photo-protective activities...
December 4, 2017: Antioxidants (Basel, Switzerland)
Tzu-En Wu, Harn-Shen Chen
BACKGROUND: This pilot study was carried to determine the prevalence of retinopathy, especially proliferative retinopathy, in patients with acromegaly. METHODS: We analyzed 43 acromegalic patients and 129 age- and gender-matched patients with type 2 diabetes. The retinopathy status was determined from the medical records based on the ophthalmologist consultations of patients with acromegaly. Color photographs of the macula- and disc-centered views were obtained at an angle of 45° with a fundus camera after pharmacologic-induced mydriasis in patients with type 2 diabetes...
March 2018: Journal of the Chinese Medical Association: JCMA
Alec L Amram, Clint Kellogg, Ahmed Elkeeb
PURPOSE: To present a case of idiopathic foveal retinoschisis in a patient with new-onset proliferative diabetic retinopathy. METHODS: Single case report. RESULTS: A 64-year-old African American man with Type 2 diabetes mellitus presented for a routine annual diabetic eye examination with mildly blurred vision at near and distance in the right eye. Fluorescein angiography demonstrated optic nerve leakage consistent with neovascularization of the disk but no leakage on or around the macula in the right eye...
November 22, 2017: Retinal Cases & Brief Reports
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