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Diabetic macula

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https://www.readbyqxmd.com/read/28900543/switching-to-aflibercept-in-diabetic-macular-edema-not-responding-to-ranibizumab-and-or-intravitreal-dexamethasone-implant
#1
Antoine Herbaut, Franck Fajnkuchen, Lise Qu-Knafo, Sylvia Nghiem-Buffet, Bahram Bodaghi, Audrey Giocanti-Auregan
PURPOSE: To assess short-term functional and anatomical outcomes of refractory diabetic macular edema (DME) following a switch from ranibizumab or dexamethasone to aflibercept. METHODS: We included retrospectively eyes with persistent DME after at least 3 ranibizumab and/or one dexamethasone implant intravitreal injections (IVI). The primary endpoint was the mean change in visual acuity (VA) at month 6 (M6) after switching. RESULTS: Twenty-five eyes were included...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28834299/treatment-for-neovascular-age-related-macular-degeneration-in-sweden-outcomes-at-seven-years-in-the-swedish-macula-register
#2
Inger Westborg, Elisabet Granstam, Aldana Rosso, Susanne Albrecht, Niklas Karlsson, Monica Lövestam-Adrian
PURPOSE: To present Swedish Macula Register (SMR) data regarding treatment of neovascular age-related macular degeneration (AMD) in clinical practice since 2008. METHODS: A retrospective register-based study was conducted. Evaluation of baseline demographics, visual outcome and number of injections during this period is presented. RESULTS: Mean age at diagnosis was 79 ± (SD) 8 years; 65% were female. The proportion of patients with <2 months' duration of symptoms increased from 26% in 2008 to 41% in 2014 (p = 0...
August 21, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28820183/technique-of-retinal-gene-therapy-delivery-of-viral-vector-into-the-subretinal-space
#3
K Xue, M Groppe, A P Salvetti, R E MacLaren
PurposeSafe and reproducible delivery of gene therapy vector into the subretinal space is essential for successful targeting of the retinal pigment epithelium (RPE) and photoreceptors. The success of surgery is critical for the clinical efficacy of retinal gene therapy. Iatrogenic detachment of the degenerate (often adherent) retina in patients with hereditary retinal degenerations and small volume (eg, 0.1 ml) subretinal injections pose new surgical challenges.MethodsOur subretinal gene therapy technique involved pre-operative planning with optical coherence tomography (OCT) and autofluorescence (AF) imaging, 23 G pars plana vitrectomy, internal limiting membrane staining with Membrane Blue Dual (DORC BV, Zuidland, Netherlands), a two-step subretinal injection using a 41 G Teflon tipped cannula (DORC) first with normal saline to create a parafoveal bleb followed by slow infusion of viral vector via the same self-sealing retinotomy...
September 2017: Eye
https://www.readbyqxmd.com/read/28796149/visual-and-anatomical-outcomes-after-diabetic-traction-and-traction-rhegmatogenous-retinal-detachment-repair
#4
Philip P Storey, Anna Ter-Zakarian, Shannon A Philander, Lisa Olmos de Koo, Meena George, Mark S Humayun, Damien C Rodger, Hossein Ameri
PURPOSE: To evaluate visual and anatomical outcomes of diabetic tractional retinal detachment repaired with pars plana vitrectomy. METHODS: Operative records were used to retrospectively identify all patients with tractional retinal detachments secondary to proliferative diabetic retinopathy surgically repaired with pars plana vitrectomy between November 1, 2009, and January 1, 2015 at the LAC + USC (Los Angeles County + University of Southern California) Medical Center...
August 8, 2017: Retina
https://www.readbyqxmd.com/read/28759755/the-roles-of-sodium-glucose-cotransporter-2-inhibitors-in-preventing-kidney-injury-in-diabetes
#5
REVIEW
Krit Jaikumkao, Anchalee Pongchaidecha, Varanuj Chatsudthipong, Siriporn C Chattipakorn, Nipon Chattipakorn, Anusorn Lungkaphin
Diabetic nephropathy (DN) is the leading cause of end stage renal disease (ESRD) worldwide. The early effective treatment of high plasma glucose could delay or prevent the onset of DN. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are new target treatments for ameliorating high plasma glucose and help to maintain glucose homeostasis in diabetic patients. Reduced renal glucose reabsorption by SGLT2 inhibition seems to have high potential to improve glycemic control in diabetes mellitus (DM) not only through glucose lowering but also through glucose-independent effects such as blood pressure-lowering and direct renal effects in diabetes...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28735646/hyperhomocysteinemia-and-age-related-macular-degeneration-role-of-inflammatory-mediators-and-pyroptosis-a-proposal
#6
Mahavir Singh, Suresh C Tyagi
Age-related macular degeneration (AMD) and pyroptosis cause irreversible vascular changes in the eyes leading to central vision loss in patients. It is the most common eye disease affecting millions of people aged 50years or older, and is slowly becoming a major health problem worldwide. The disease mainly affects macula lutea, an oval-shaped pigmented area surrounding fovea near the center of retina, a region responsible for visual acuity. It is fairly a complex disease as genetics of patients, environmental triggers as well as risk factors such as age, family history of CVDs, diabetes, gender, obesity, race, hyperopia, iris color, smoking, diabetes, exposure to sun light and pyroptosis have all been clubbed together as probable causes of macular degeneration...
August 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28728160/structural-changes-of-the-macula-on-optical-coherence-tomography-after-vitrectomy-for-proliferative-diabetic-retinopathy
#7
Jong Chan Im, Jong Ho Kim, Dong Ho Park, Jae Pil Shin
PURPOSE: This study aimed to evaluate the relationship between macular structural changes and visual prognosis after pars plana vitrectomy (PPV) for proliferative diabetic retinopathy. METHODS: The study included 60 eyes that had undergone PPV. Macular optical coherence tomography (OCT) findings were classified into 5 groups preoperatively and 10 groups postoperatively. Best-corrected visual acuity (BCVA) were analyzed according to pre- and postoperative OCT. RESULTS: From the preoperative OCT, normal fovea with/without traction, normal fovea with preretinal hemorrhage, and tractional retinal detachment involving fovea showed an increase in BCVA after PPV (all p < 0...
July 21, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28719903/thinning-of-inner-retinal-layers-after-vitrectomy-with-silicone-oil-versus-gas-endotamponade-in-eyes-with-macula-off-retinal-detachment
#8
Konstantine Purtskhvanidze, Jost Hillenkamp, Jan Tode, Olaf Junge, Jürgen Hedderich, Johann Roider, Felix Treumer
PURPOSE: To evaluate retinal layer thickness with optical coherence tomography (OCT) in eyes with macula-off retinal detachment after silicone oil (SiO) or gas endotamponade. PROCEDURES: Cross-sectional study of 40 eyes with macula-off rhegmatogenous retinal detachment that underwent vitrectomy. 20 eyes received SiO tamponade and 20 matched eyes received gas. 33 healthy fellow eyes served as controls. Macular spectral domain OCT was performed with automated layer detection in the 5 inner subfields of the Early Treatment Diabetic Retinopathy Study (ETDRS) map...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28669781/prevalence-of-diabetic-retinopathy-and-blindness-in-indonesian-adults-with-type-2-diabetes
#9
Muhammad Bayu Sasongko, Felicia Widyaputri, Angela Nurini Agni, Firman Setya Wardhana, Satyaprabha Kotha, Prateek Gupta, Tri Wahyu Widayanti, Supanji Haryanto, Rifa Widyaningrum, Tien Yin Wong, Ryo Kawasaki, Jie Jin Wang
PURPOSE: To report the prevalence of diabetic retinopathy (DR) and DR-related blindness in an Indonesian population with type 2 diabetes. METHODS: Design: Population-based cross-sectional study. SETTING: Community health centers. STUDY POPULATION: We recruited 1184 people aged older than 30 years with type 2 diabetes residing in Jogjakarta, Indonesia. Multistage, clustered random sampling based on regencies and districts in Jogjakarta was used...
September 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28667491/sglt-2-inhibitors-in-heart-failure-implications-for-the-kidneys
#10
REVIEW
Frederik H Verbrugge, Pieter Martens, Wilfried Mullens
PURPOSE OF REVIEW: This review aims to summarize the renal effects of sodium-glucose transporter-2 (SGLT-2) inhibitors and their potential implications in heart failure pathophysiology. RECENT FINDINGS: In patients with diabetes and established atherosclerosis, the SGLT-2 inhibitor empagliflozin versus placebo significantly reduced the rate of heart failure admissions with 35%. Moreover, empagliflozin slowed kidney disease progression and reduced the need for renal replacement therapy...
August 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28658588/utility-of-1-tropicamide-in-improving-the-quality-of-images-for-tele-screening-of-diabetic-retinopathy-in-patients-with-dark-irides
#11
Touka Banaee, Mohammad-Reza Ansari-Astaneh, Hamidreza Pourreza, Fatemeh Faal Hosseini, Maryam Vatanparast, Nasser Shoeibi, Vajihe Jami
PURPOSE: To compare the quality of fundus photographs taken before and after instillation of one drop of tropicamide. METHODS: The 45º fundus photographs were taken with a non-mydriatic fundus camera in three conditions of the pupil; pre-mydriatic, 10 minutes after one drop of tropicamide, and fully dilated. Two photographs were taken in each condition; one centered on the macula and the other on the optic disc. Two vitreoretinal specialists graded the images. RESULTS: A total of 1768 fundus photographs of 149 diabetic patients with dark irides were included...
August 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28611649/a-case-of-diabetic-macular-edema-with-prominent-chorioretinal-folds
#12
Takaki Sato, Ryohsuke Kohmoto, Masanori Fukumoto, Seita Morishita, Daisaku Kimura, Kensuke Tajiri, Takatoshi Kobayashi, Teruyo Kida, Shota Kojima, Tsunehiko Ikeda
PURPOSE: To report a case of diabetic macular edema with prominent chorioretinal folds. CASE REPORT: This study involved a 55-year-old male with untreated bilateral diabetic retinopathy who had undergone cataract surgery at another clinic. Following that surgery, diabetic macular edema rapidly exacerbated, accentuating marked cystoid macular edema and radial chorioretinal folds in the macula. Investigation of his medical history revealed that in addition to diabetes, he had uncontrolled hypertension and severe diabetic nephropathy...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28567164/pars-plana-vitrectomy-with-internal-limiting-membrane-peeling-for-nontractional-diabetic-macular-edema
#13
Jan Niklas Ulrich
BACKGROUND: Diabetes mellitus remains the leading cause of blindness among working age Americans with diabetic macular edema being the most common cause for moderate and severe vision loss. OBJECTIVE: To investigate the anatomical and visual benefits of pars plana vitrectomy with inner limiting membrane peeling in patients with nontractional diabetic macular edema as well as correlation of integrity of outer retinal layers on spectral domain optical coherence tomography to visual outcomes...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28542922/study-of-retinal-neurodegeneration-and-maculopathy-in-diabetic-meriones-shawi-a-particular-animal-model-with-human-like-macula
#14
Imane Hammoum, Maha Benlarbi, Ahmed Dellaa, Klaudia Szabó, Bulcsú Dékány, Dávid Csaba, Zsuzsanna Almási, Rozina I Hajdú, Rached Azaiz, Ridha Charfeddine, Ákos Lukáts, Rafika Ben Chaouacha-Chekir
The purpose of this work was to evaluate a potentially useful animal model, Meriones shawi (M.sh)-developing metabolic X syndrome, diabetes and possessing a visual streak similar to human macula-in the study of diabetic retinopathy and diabetic macular edema (DME). Type 2 diabetes (T2D) was induced by high fat diet administration in M.sh. Body weights, blood glucose levels were monitored throughout the study. Diabetic retinal histopathology was evaluated 3 and 7 months after diabetes induction. Retinal thickness was measured, retinal cell types were labeled by immunohistochemistry and the number of stained elements were quantified...
May 20, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28542693/macular-sensitivity-measured-with-microperimetry-in-stargardt-disease-in-the-progression-of-atrophy-secondary-to-stargardt-disease-progstar-study-report-no-7
#15
MULTICENTER STUDY
Etienne M Schönbach, Yulia Wolfson, Rupert W Strauss, Mohamed A Ibrahim, Xiangrong Kong, Beatriz Muñoz, David G Birch, Artur V Cideciyan, Gesa-Astrid Hahn, Muneeswar Nittala, Janet S Sunness, SriniVas R Sadda, Sheila K West, Hendrik P N Scholl
Importance: New outcome measures for treatment trials for Stargardt disease type 1 (STGD1) and other macular diseases are needed. Microperimetry allows mapping of light sensitivity of the macula and provides topographic information on visual function beyond visual acuity. Objective: To measure and analyze retinal light sensitivity of the macula in STGD1 using fundus-controlled perimetry (microperimetry). Design, Setting, and Participants: This was a multicenter prospective cohort study...
July 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28508191/investigations-of-severity-level-measurements-for-diabetic-macular-oedema-using-machine-learning-algorithms
#16
S Murugeswari, R Sukanesh
BACKGROUND: The macula is an important part of the human visual system and is responsible for clear and colour vision. Macular oedema happens when fluid and protein deposit on or below the macula of the eye and cause the macula to thicken and swell. Normally, it occurs due to diabetes called diabetic macular oedema. Diabetic macular oedema (DME) is one of the main causes of visual impairment in patients. AIM: The aims of the present study are to detect and localize abnormalities in blood vessels with respect to macula in order to prevent vision loss for the diabetic patients...
May 15, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28499163/the-diabetic-retinopathy-barometer-study-global-perspectives-on-access-to-and-experiences-of-diabetic-retinopathy-screening-and-treatment
#17
D Cavan, L Makaroff, J da Rocha Fernandes, M Sylvanowicz, P Ackland, J Conlon, D Chaney, A Malhi, J Barratt
AIM: To assess the level of awareness, prevention and treatment of Diabetic Eye Disease (DED) comprising Diabetic Retinopathy (DR) and Diabetic Macula Edema (DME) retinopathy among adults with diabetes and health professionals. METHODS: The Diabetic Retinopathy Barometer Study consisted of a qualitative study, which consisted of semi-structured interviews, and a quantitative study using online surveys for adults with diabetes and for health professionals. RESULTS: A total of 4340 adults with diabetes and 2329 health professionals participated in the surveys...
July 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28480495/retinopathy-with-central-oedema-in-an-ins-c94y-transgenic-pig-model-of-long-term-diabetes
#18
Kristina J H Kleinwort, Barbara Amann, Stefanie M Hauck, Sieglinde Hirmer, Andreas Blutke, Simone Renner, Patrizia B Uhl, Karina Lutterberg, Walter Sekundo, Eckhard Wolf, Cornelia A Deeg
AIMS/HYPOTHESIS: Diabetic retinopathy is a severe complication of diabetes mellitus that often leads to blindness. Because the pathophysiology of diabetic retinopathy is not fully understood and novel therapeutic interventions require testing, there is a need for reliable animal models that mimic all the complications of diabetic retinopathy. Pig eyes share important anatomical and physiological similarities with human eyes. Previous studies have demonstrated that INS (C94Y) transgenic pigs develop a stable diabetic phenotype and ocular alterations such as cataracts...
August 2017: Diabetologia
https://www.readbyqxmd.com/read/28452993/structural-and-functional-changes-to-the-retina-and-optic-nerve-following-panretinal-photocoagulation-over-a-2-year-time-period
#19
R Filek, P Hooper, T Sheidow, J Gonder, D K Varma, L Heckler, W Hodge, S Chakrabarti, C M L Hutnik
PurposeTo evaluate long-term structural and functional changes to the retina and optic nerve following panretinal photocoagulation (PRP) in diabetic retinopathy (DR) patients.MethodsParticipants were patients with DR requiring PRP and control patients with DR not requiring PRP. The Heidelberg retinal tomography (HRT) and optical coherence tomography (OCT) were performed to analyze the optic nerve and macula. Best-corrected visual acuity (BCVA) and visual field (VF) testing were done to measure central and peripheral vision...
August 2017: Eye
https://www.readbyqxmd.com/read/28440254/combined-branch-retinal-vein-and-branch-retinal-artery-occlusion-clinical-features-systemic-associations-and-outcomes
#20
Sabyasachi Sengupta, Utsab Pan
PURPOSE: Retinal vascular occlusions affecting both the arterial and venous systems are rare events. Combined branch retinal artery (BRAO) and vein (BRVO) occlusion are exceedingly rare and not well characterized. METHODS: Six patients with combined BRAO and BRVO underwent a comprehensive eye examination, fundus fluorescein angiography, optical coherence tomography, and cardiovascular evaluation. RESULTS: Mean age at presentation was 54 ± 7...
March 2017: Indian Journal of Ophthalmology
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